Log in

Relevant bibliographies by topics / Aldosteronism / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Aldosteronism.

Dissertations / Theses on the topic 'Aldosteronism'

Author: Grafiati

Published: 11 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 37 dissertations / theses for your research on the topic 'Aldosteronism.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Ronconi, Vanessa. "The cardiometabolic syndrome in primary aldosteronism: role of adipose tissue." Doctoral thesis, Università Politecnica delle Marche, 2010. http://hdl.handle.net/11566/242153.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Kohmo, Kyoko. "Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism." Kyoto University, 2015. http://hdl.handle.net/2433/200439.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Donà, Gabriella. "Human red blood cells alterations in Primary Aldosteronism: Mineralocorticoid Receptor (MR) involvement in the Aldosterone pathway." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423923.

Full text

Abstract:

Red blood cells (RBCs) are a-nucleated cells particularly exposed to different stimuli, among which circulating hormones and intra/extra-cellular derivatives from oxidization processes. In addition, our previous studies showed that in the case of inflammatory diseases with GSH content alterations, RBCs were much more sensitive to diamide, a mild oxidant able to trigger tyrosine-phosphorylation (Tyr-P) of membrane proteins, mainly band 3. Aldosterone (Aldo), mineralocorticoid hormone, has been shown to induce many effects other than the common diuretic process regulation and involving the exp

APA, Harvard, Vancouver, ISO, and other styles

4

Aldighieri, Enrico. "Human primary aldosteronism; investigation of the mechanism leading to autonomous aldosterone excess." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3421768.

Full text

Abstract:

Objective: Due to its unique expression of aldosterone synthase cytocromo P450 (CYP11B2), the enzyme required for the final steps of aldosterone biosynthesis aldosterone is exclusively expressed in the adrenalcortical zona glomerulosa cell. Some studies suggested that the CYP11B2 gene expression can be higher in APAs than in normal adrenocortical tissues, leading to postulate a transcriptional modulation of aldosterone overproduction in these tumors but antibodies capable to identify this protein do not exist. Thus we performed studies of in-situ hybridization (ISH) to analyze CYP11B2 localiza

APA, Harvard, Vancouver, ISO, and other styles

5

MacConnachie, Alisdair A. "Investigation of the prevalence and genetic characterisation of patients with glucocorticoid remediable aldosteronism." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU528796.

Full text

Abstract:

After the elucidation of the underlying genetic cause in many Mendellian diseases molecular medicine has turned its attention to the more common polygenic disorders. High blood pressure is one such complex trait which has been the subject of much interest in recent years. A number of candidate loci have been found to different groups to influence blood pressure and have been implicated in the aetiology of essential hypertension although the most significant discoveries have been in the single gene causes of high blood pressure. Glucocorticoid remediable aldosteronism (GRA) is an autosomal domi

APA, Harvard, Vancouver, ISO, and other styles

6

Csonka, Enikö. "Method verification for aldosterone and renin assay - a reliable screening test for primary aldosteronism." Thesis, Uppsala universitet, Forskargrupper (Inst. för kvinnor och barns hälsa), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358217.

Full text

Abstract:

Primary aldosteronism (PA) is a common form of secondary hypertension with an international prevalence rates between 5 and 10 %. It is characterized by a high autonomous aldosterone production that causes cardiovascular damage, renin suppression, hypertension, sodium retention, potassium excretion and hypokalemia. The screening of PA is a simple test measuring aldosterone to renin ratio (ARR) with immunoassay method. This test is currently considered as the most reliable screening tool for PA. The main objective of the study was to evaluate an ELISA-method, for detection of aldosterone an

APA, Harvard, Vancouver, ISO, and other styles

7

ZHU, RUI. "Simplification of the diagnostic work-up of primary aldosteronism and investigation of immunology mechanisms." Doctoral thesis, Università degli studi di Padova, 2022. http://hdl.handle.net/11577/3443120.

Full text

Abstract:

Background Primary aldosteronism (PA) is the most common cause of arterial hypertension characterized by high levels of aldosterone, resulting in excessive mineralocorticoid receptor (MR) stimulation, and extensive hypertensive-mediated organ damage (HMOD). Current guidelines recommend one or more exclusion tests in patients performed the screening test with the measurement of aldosterone-to-renin ratio (ARR) to avoid further lateralization procedures in those who tested false-positive. To date the diagnostic gain provided by these exclusion tests over the ARR was examined only in few studie

APA, Harvard, Vancouver, ISO, and other styles

8

Citton, Marilisa. "Effect of unilateral adrenalectomy on the quality of life of patients with lateralized primary aldosteronism." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3422284.

Full text

Abstract:

Background. Previous studies reported that primary aldosteronism (PA) is associated with an increased prevalence of anxiety, depression and subnormal quality of life (QoL) scores that may be improved after surgical treatment. Aim of the Study. The aim of the study was to assess the impact of surgery on health-related QoL and depression status of patients suffering from PA, comparing the results with a control group of patients undergoing surgery for a non-secreting adrenal tumor. Materials and Methods. Data on QoL and depression status were prospectively collected, from January 2014 to Oct

APA, Harvard, Vancouver, ISO, and other styles

9

Reimer, Esther [Verfasser], Ute [Gutachter] Scholl, and Christoph [Gutachter] Fahlke. "Investigations of somatic and germline mutations in primary aldosteronism / Esther Reimer ; Gutachter: Ute Scholl, Christoph Fahlke." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1152076280/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Ohno, Youichi. "Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan." Kyoto University, 2019. http://hdl.handle.net/2433/242409.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Armstrong, Robin Sherill. "Anger and anxiety in patients with primary aldosteronism treated with amiloride hydrochloride or spironolactone or adrenalectomy." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16375/1/Robin_Armstrong_Thesis.pdf.

Full text

Abstract:

In Primary Aldosteronism (PAL) excessive amounts of aldosterone cause sodium and water retention and, in many individuals, this leads to moderate to severely high blood pressure. Although the chemistry and physiology are increasingly well understood, including the outcomes of treatment on physical health, there has been no systematic study of the psychological dimension of PAL. Anecdotally, patients exhibit symptoms such as angry outbursts, irritability, anxiety and defensiveness, and partners of these patients sometimes mention poor anger control and brittle or unpredictable moods. This thesi

APA, Harvard, Vancouver, ISO, and other styles

12

Armstrong, Robin Sherill. "Anger and anxiety in patients with primary aldosteronism treated with amiloride hydrochloride or spironolactone or adrenalectomy." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16375/.

Full text

Abstract:

In Primary Aldosteronism (PAL) excessive amounts of aldosterone cause sodium and water retention and, in many individuals, this leads to moderate to severely high blood pressure. Although the chemistry and physiology are increasingly well understood, including the outcomes of treatment on physical health, there has been no systematic study of the psychological dimension of PAL. Anecdotally, patients exhibit symptoms such as angry outbursts, irritability, anxiety and defensiveness, and partners of these patients sometimes mention poor anger control and brittle or unpredictable moods. This thesi

APA, Harvard, Vancouver, ISO, and other styles

13

Recarti, Chiara. "The prorenin receptor in the adrenal gland: expression, localization, signalling pathway and potential role in primary aldosteronism." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422137.

Full text

Abstract:

Primary aldosteronism (PA) comprises about 11% patients referred to specialized centers for Arterial Hypertension. A considerable part of them carry a bilateral adrenocortical hyperplasia, also known as, idiopathic hypertension, which require life-long medical treatment. Notwithstanding this high prevalence rate the mechanisms leading to PA are unknown. However, anecdotal reports suggest that prorenin levels could be increased in PA, although the low or undetectable levels of active plasma renin, plasma prorenin levels could be increased. This suggests a possible role of prorenin in the pathop

APA, Harvard, Vancouver, ISO, and other styles

14

Gonzalez, Campos Abril. "Isolation of human parathyroid cell type as a tool for investigating the mechanisms of human primary aldosteronism." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423663.

Full text

Abstract:

Background. The detection of the mineralocorticoid receptor in parathyroid cells alongside recent evidences implicating the parathyroid hormone (PTH) in overproduction of aldosterone in primary aldosteronism in spite of suppression of the renin-angiotensin system indicate a relationship between parathyroids and the adrenocortical zona glomerulosa. The investigation of this relationship has been hampered due to lack of parathyroid cell line suitable for in vitro studies. Objective. To develop a technique to obtain a primary culture of human parathyroid cells with high yield and purity and to

APA, Harvard, Vancouver, ISO, and other styles

15

Cesari, Maurizio. "Long-term modifications in left ventricular structure and function after adrenalectomy or medical treatment in patients with primary aldosteronism." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425063.

Full text

Abstract:

Background and aim: hyperaldosteronism has been related to collagen deposition, myocardial fibrosis, and ventricular remodeling in experimental studies. More recent evidence suggest that these detrimental effects can develop independently of blood pressure and a significant decrease in the mortality rate of patients with heart failure who were treated with aldosterone antagonists has been reported. Primary aldosteronism (PA) is a form of secondary arterial hypertension that offers an important clinical opportunity for assessing the effects of hyperaldosteronism on the left ventricular (LV) a

APA, Harvard, Vancouver, ISO, and other styles

16

Tareen, Shahwali Khan. "Analyse moléculaire des canaux potassiques task dans l'aldostéronisme primaire humain." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066056.

Full text

Abstract:

L'hyperaldostéronisme primaire (HAP) est la plus fréquente cause identifiable de l'hypertension, et résulte de la production autonome d'aldostérone par les glandes surrénales. Chez la souris, la délétion génétique des canaux TASK1 et TASK3 provoque des changements biochimiques qui imitent HAP humain. Ces canaux permet la sortie de K+ et polarise le potentiel de la membrane des cellules glomérules. Nous avons étudié la variation et l'expression de KCNK3 et 9 chez l'homme. Notre étude d'association à montré aucune association d'HAP avec n'importe quel SNP au niveau de l'ensemble du génome. Le sé

APA, Harvard, Vancouver, ISO, and other styles

17

Gioco, Francesca. "CYP11B2/CYP11B1 Immunophenotyping of 111 Adrenal Glands Excised from Primary Aldosteronism Patients leads to a Novel Classification of the Disease." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424957.

Full text

Abstract:

Background. Primary Aldosteronism (PA) is due to the presence of an Aldosterone-Producing Adenoma (APA) in almost two thirds of the cases. Due to the lack of a specific antibody for human aldosterone synthase (hCYP11B2), the functional identification of aldosterone-producing sites in the excised adrenal gland has not been possible thus far. To tackle this challenge we used novel monoclonal antibodies for hCYP11B2 and hCYP11B1 to immuno-phenotype a large series of adrenal glands excised from patients with PA, including APA that were diagnosed by the “four corners criteria” and genotyped for K

APA, Harvard, Vancouver, ISO, and other styles

18

menegolo, mirko. "Human primary aldosteronism: from clinical observations to in-vivo and ex-vivo studies on the pressor effects of Urotensin II." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426182.

Full text

Abstract:

In a patient affected by primary aldosteronism we have identified the presence of a pheochromocytoma not secreting catecholamines. The analysis of the transcriptome in the pheochromocytoma revealed a high expression of Urotensin II (UII). UII is a somatostatin-like cyclic 11-aminoacid vasoconstrictor peptide, first identified in the teleost fish caudal-neuro-secretory system and then in humans, that has been demonstrated to be a potent vasoactive peptide involved in the physiology and pathophysiology of the cardiovascular system through mechanisms still largely unknown. Its action is now the

APA, Harvard, Vancouver, ISO, and other styles

19

Cangiano, daniela. "Detection of KCNJ5 mutations in the APA tissues and cell-free DNA with a novel Taqman-based approach." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424711.

Full text

Abstract:

Background: Primary aldosteronism (PA) is the most common endocrine form of secondary arterial hypertension with an estimated prevalence of ~ 11.2% in patients referred to specialized centers and 4% in primary care, but as high as 50% in patients with resistant hypertension. The two main forms of PA are: aldosterone-producing adenoma (APA), surgically curable with the removal of adenoma that is able to overproduce aldosterone, and bilateral adrenocortical hyperplasia (BAH), which needs drug therapy. About ~ 30% APAs have somatic mutations in KCNJ5 gene that encodes for the potassium channel (K

APA, Harvard, Vancouver, ISO, and other styles

20

Kuppusamy, Maniselvan. "Prevalence of KCNJ5 mutations and functional impact of a novel KCNJ5-insT149 mutation in aldosterone producing adenoma causing resistant hypertension." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423810.

Full text

Abstract:

Primary aldosteronism (PA), a common form of secondary hypertension, is characterized by an excess autonomous aldosterone secretion. In a percentage ranging from a half to two thirds of the cases it is due to a surgically curable aldosterone-producing adenoma (APA) and in the rest to bilateral adrenal hyperplasia. The molecular mechanisms underlying aldosterone hypersecretion are unknown. Recent evidences suggest that amino acid residue substitutions in the selectivity filter of the Kir3.4 (KCNJ5) potassium channel may cause a constitutive aldosterone secretion from aldosterone-producing ade

APA, Harvard, Vancouver, ISO, and other styles

21

Remde, Hanna [Verfasser]. "High sensitive CRP and copeptin levels in patients with primary aldosteronism compared to hypertensive subjects : Data from the German Conn's registry and the KORA F4 Survey / Hanna Remde." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/119437624X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Maniero, Carmela. "A functional study on novel genes involved in regulating aldosterone secretion in normal human zona glomerulosa and in aldosterone-producing adenomas." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270313.

Full text

Abstract:

Primary aldosteronism is the most common secondary cause of hypertension with a prevalence of about 10%. About half of PA cases are caused by aldosterone-producing adenomas (APA). Two APA subtypes, ZG-like and ZF-like APAs, have been described, according to the histological resemblance to normal zona glomerulosa (ZG) and zona fasciculata (ZF), underlying somatic mutations (KCNJ5 commonly found in ZF-like, CACN1AD, ATP1A1, ATP2B3, CTNNB1 in ZG-like APAs), and transcriptome profile. It is unknown if the process of tumorigenesis differs between ZG- and ZF-like APAs. In order to define ZG specific

APA, Harvard, Vancouver, ISO, and other styles

23

Cicala, Maria Verena. "Ruolo del cateterismo delle vene surrenaliche nell'iperaldosteronismo primitivo. Impatto di differenti criteri diagnostici nella diagnosi di sottotipo." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3421748.

Full text

Abstract:

In patients with primary aldosteronism (PA), adrenal vein sampling (AVS) is considered the gold standard to distinguish between unilateral and bilateral autonomous production of aldosterone, while diagnostic imaging tests by CT scan or MRI are useful but often inconclusive for the diagnosis of PA. To date agreement is lacking on the best criteria indicating successful cannulation and lateralization. The aim of the study was to evaluate the impact of different diagnostic criteria for the successful cannulation and lateralization on subtype diagnosis and to compare the difference of the finding

APA, Harvard, Vancouver, ISO, and other styles

24

Amar, Laurence. "Identification de nouvelles options thérapeutiques et diagnostiques dans l'hyperaldostéronisme primaire." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T075/document.

Full text

Abstract:

L’hyperaldostéronisme primaire [HAP] résulte d’une hypersécrétion d’aldostérone d’origine surrénale. La compréhension de la pathogénie de cette maladie, dont la prévalence est estimée à 10% de la population hypertendue, est essentielle pour le développement de nouveaux outils diagnostiques et thérapeutiques. Dans ce contexte, ce travail de doctorat avait pour but d’identifier de nouvelles orientations thérapeutiques en testant un inhibiteur de l’aldostérone synthase et de rechercher de nouveaux marqueurs diagnostiques par l’étude du profil d’expression des microARN [miRs]. Dans une étude de ph

APA, Harvard, Vancouver, ISO, and other styles

25

Wilzewski, Britta [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Untersuchung von Mineralocorticoidrezeptor-unabhängigen Effekten des Aldosterons in Mammalierzellkulturen / Britta Wilzewski. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051434335/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Lin, Yen-Hung, and 林彥宏. "Remodeling of cardiac structure in patients with primary aldosteronism." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06424142066840417259.

Full text

Abstract:

博士<br>國立臺灣大學<br>臨床醫學研究所<br>100<br>Primary aldosteronism (PA) is a curable and common hypertensive disease, and is characterized by an inappropriate production of aldosterone. PA, the prevalence of which is around 5-10% of patients with hypertension, consists of two subtypes: aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA). Patients with PA have been shown to have a higher prevalence of cardiovascular events and atrial fibrillation than patients with essential hypertension (EH), which are independent of blood pressure effects. In addition, patients with PA have a mo

APA, Harvard, Vancouver, ISO, and other styles

27

Liao, Che-Wei, and 廖哲偉. "Reversal of Arterial Stiffness in Primary Aldosteronism After Treatment." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/43173817545587069410.

Full text

Abstract:

碩士<br>國立臺灣大學<br>臨床醫學研究所<br>103<br>Primary aldosteronism (PA) was one of the most common causes of secondary hypertension. Exposure to excessive aldosterone led to increased arterial stiffness. The effect of adrenalectomy on arterial stiffness reversibility was seldom reported. Besides, the time course of arterial stiffness reversal and the actual predicting factors on arterial stiffness reversal were still unclear. We prospectively enrolled 102 patients with aldosterone producing adenoma (APA) from March 2006 to January 2012. We measured the pulse wave velocity (PWV) between brachial

APA, Harvard, Vancouver, ISO, and other styles

28

Lu, Ching-Chu, and 路景竹. "Cost-effectiveness Analysis of Computed Tomography and Adrenal Scintigraphy in Primary Aldosteronism." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89926143326025240193.

Full text

Abstract:

碩士<br>國立臺灣大學<br>健康政策與管理研究所<br>99<br>Background：Primary aldosteronism is the most common cause of secondary hypertension. The two main causes of primary aldosteronism are aldosterone-producing adenoma, which could be cured by surgical intervention, and bilateral adrenal hyperplasia, which should be medical-treated. Computed tomography, adrenal venous sampling and adrenal scintigraphy are usually used for the etiology and lateralization of primary aldosteronism. Computed tomography is based on the anatomical findings, but it has wide variation of sensitivity. Adenal venous sampling is the gold s

APA, Harvard, Vancouver, ISO, and other styles

29

CRIMI', FILIPPO. "Imaging by CT and MR in primary aldosteronism: in a pilot study, the AVIS-2-IM study and the AVIS-2-Young study." Doctoral thesis, 2021. http://hdl.handle.net/11573/1531714.

Full text

Abstract:

The present thesis is a collection of the main research studies concerning imaging in PA, conducted during the PhD Course. In the second and third chapters, starting from the large cohort of PA patients recruited in the AVIS-2 study, we investigated respectively: a) if imaging by CT and/or MR could permit an accurate detection of PA and identification of unilateral PA; b) if a unilateral hypodense adrenal nodule alongside a contralateral normally appearing adrenal gland at imaging, can allow an accurate identification of unilateral surgically curable PA in patients aged 45 years or younger

APA, Harvard, Vancouver, ISO, and other styles

30

Chou, Yi-Ling, and 周怡伶. "A Study of Data Mining Applied to the Predictive Model of 「Primary aldosteronism」." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/85095336392636756738.

Full text

Abstract:

碩士<br>雲林科技大學<br>工業工程與管理研究所碩士班<br>96<br>Typical hypertension and Primary aldosteronism (PA) are the top two reasons for hypertension. Primary aldosteronism affects 5-15% of patients with hypertension. A PA patient could have hypertension and hypokalemia, but the study found that a PA patient may not have hypokalemia. It needs more indicators to diagnose PA. Typical hypertension and PA were often misjudged. This study applied Logistic regression analysis, C5.0, CART and Back-propagation Network to compare the prediction accuracy of PA. The best model is Logistic regression analysis. The Logist

APA, Harvard, Vancouver, ISO, and other styles

31

Šomlóová, Zuzana. "Metabolické a strukturální rozdíly u primárního hyperaldosteronismu a esenciální hypertenze." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-322926.

Full text

Abstract:

Hypertension is a major risk factor for cardiovascular (CV) disease, and patients with primary aldosteronism (PA) - the most common endocrine cause of hypertension - have a higher incidence of CV complications. The aim of this study was to evaluate the incidence of metabolic differences and organ complications - kidney, heart and blood vessels damage in patients with essential hypertension (EH), PA and its most common forms - idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA). We found a higher incidence of metabolic syndrome and a higher incidence of metabolic abnorma

APA, Harvard, Vancouver, ISO, and other styles

32

Indra, Tomáš. "Remodelace levé komory srdeční u pacientů s primárním hyperaldosteronismem a esenciální hypertenzí." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-265180.

Full text

Abstract:

Myocardial damage is one of the most serious consequences of arterial hypertension. Changes in the heart structure and function develop not only due to pressure overload itself, but many other hemodynamic and neurohumoral factors contribute to their formation. Our work has compared echocardiohraphic strucutural anf functional changes of the left ventricle, caused by essential hypertension and hypertension associated with primary aldosteronism (PA) as the most common reason for secondary hypertension. The first part of our work focused on the differences in left ventricle geometry in men with P

APA, Harvard, Vancouver, ISO, and other styles

33

Rosa, Ján. "Charakteristika velkých tepen u primární a sekundární - endokrinní hypertenze." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-297730.

Full text

Abstract:

Arterial stiffness represented by carotid-femoral pulse wave velocity (PWV) is considered to be an independent cardiovascular risk factor. This study was focused on large artery properties investigation in specific forms of hypertension using applanation tonometer Sphygmocor (Atcor Medical). PWV was significantly higher in resistant hypertension patients when compared to moderate essential hypertension (EH) patients. This difference appears to be independent of clinical blood pressure (BP). Night-time BP appears to be a more accurate predictor of PWV in EH. In another study we demonstrated tha

APA, Harvard, Vancouver, ISO, and other styles

34

Lampron, Antoine. "Élucidation des mécanismes moléculaires impliqués dans l’expression aberrante du récepteur au peptide insulinotropique glucose-dépendant (GIP) dans les tumeurs du cortex de la glande surrénale." Thèse, 2009. http://hdl.handle.net/1866/4103.

Full text

Abstract:

Les tumeurs du cortex surrénalien sont variées et fréquentes dans la population. Bien que des mutations aient été identifiées dans certains syndromes familiaux, les causes génétiques menant à la formation de tumeur du cortex surrénalien ne sont encore que peu connues. Un sous-type de ces tumeurs incluent les hyperplasies macronodulaires et sont pressenties comme la voie d’entrée de la tumorigenèse du cortex surrénalien. L’événement génétique le plus fréquemment observé dans ces tumeurs est l’expression aberrante d’un ou plusieurs récepteurs couplés aux protéines G qui contrôle la production de

APA, Harvard, Vancouver, ISO, and other styles

35

Wu, Vin-Cent, and 吳允升. "Endothelial progenitor cells in primary aldosteronism:a biomarker of severity for aldosterone vasculopathy and prognosis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/70652063210886569034.

Full text

Abstract:

博士<br>國立臺灣大學<br>臨床醫學研究所<br>100<br>Growing evidence has shown that high plasma aldosterone level leads to a risk of cardiovascular diseases (CVD), including fatal stroke and sudden cardiac death. In addition, long-term exposure to increased aldosterone levels resulted in renal and metabolic sequelae independently of the blood pressure level. This phenomenon is best demonstrated in patients with primary aldosteronism (PA) who have excessive and inappropriate production of aldosterone. The excessive production of aldosterone in PA is associated with a high incidence of cardiovascular events, in c

APA, Harvard, Vancouver, ISO, and other styles

36

Kripp, Samario Tobias. "In-vitro- und in-vivo-Evaluation selektiver Aldosteronsynthase-Inhibitoren als radiofluorierte Tracer für die Nebennierenbildgebung beim primären Hyperaldosteronismus." Doctoral thesis, 2020. https://doi.org/10.25972/OPUS-21754.

Full text

Abstract:

Der primäre Hyperaldosteronismus ist eine der häufigsten Ursachen einer sekundären Hypertonie. Entscheidend für eine adäquate Therapie ist die Subtypen-Differenzierung zwischen Aldosteron produzierenden Adenomen und bilateralen Hyperplasien der Nebennierenrinde. Hierfür wird heutzutage eine selektive Katheterisierung der Nebennierenvenen durchgeführt. Diese Untersuchung ist jedoch sehr aufwendig und geht mit einer hohen Strahlenbelastung einher. Daher wurden im Rahmen dieser Arbeit 11 fluorierte Inhibitoren der Aldosteronsynthase (CYP11B2) auf ihre in-vitro- und in-vivo-Wirksamkeit und Selekti

APA, Harvard, Vancouver, ISO, and other styles

37

Safak, Erdal. "Die Bedeutung der fortlaufenden Erhöhung des Natrium- und Wasser-Bestandes für die endogene Suppression des Aldosterons und für den Anstieg des arteriellen Drucks /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012926839&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!