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Journal articles on the topic 'Alcoholism Therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Baldwin, Jeffrey N., and Kathleen A. Kriegler. "Alcoholism Treatment: A Model of Abstinence-Oriented Care." Journal of Pharmacy Practice 4, no. 6 (December 1991): 351–56. http://dx.doi.org/10.1177/089719009100400603.

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Alcohol is the United States' foremost drug of abuse. Although a significant portion of the population continues to identify alcoholism with moral weakness, society embraces treatment as the primary mode of dealing with this disease. Treatment stressing ongoing abstinence from alcohol is the most universally accepted method of therapy. Following initial intervention and referral, treatment of the alcoholic includes detoxification; intensive early treatment, using either outpatient or inpatient treatment settings; and long-term support for recovery. Aftercare programs often require continuing attendance at Alcoholics Anonymous meetings, recovery support groups, and psychotherapy. In addition, recovering individuals may receive continued health care supervision from a physician knowledgeable about alcoholism. Family therapy is stressed as a component of recovery.

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2

Dragisic-Labas, Sladjana, and Gorica Djokic. "The importance of psychoeducation in systemic family therapy alcoholic treatment." Sociologija 52, no. 2 (2010): 197–210. http://dx.doi.org/10.2298/soc1002197d.

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The main goal of the paper was to analyze the impact of psychoeducation in alcoholism therapy treatment on initial motivation and comprehension, change in attitudes to alcoholism, and beginning of creating a new value system. The sample consisted of 166 respondents (83 married couples) that had been involved in one-year systemic group family therapy alcoholic treatment (with the man being alcoholic). A questionnaire on knowledge about alcoholism was used. The respondents were tested three times - at the beginning of the treatment, after 6 months, and after one year. The results showed that the level of education had increased through three phases of the treatment, that motivation changed from initial to substantial, that the comprehension had also changed, turning family system into a more functional model of living. Statistically significant difference in level of education between phase 1 and phase 3 of the family therapy was confirmed. In conclusion, the authors argue for the importance of psychoeducation as a method in treating alcoholism.

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3

ROGERS, HELEN. "Alcoholism." Australian Occupational Therapy Journal 6, no. 3 (August 27, 2010): 18–23. http://dx.doi.org/10.1111/j.1440-1630.1959.tb00828.x.

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4

Francis, Jini P., and Viju Painadath Devassy. "Setting the Children’s Teeth on Edge? The Influence of Parental Alcoholism on Children’s Wellbeing." Artha - Journal of Social Sciences 14, no. 1 (January 1, 2015): 1. http://dx.doi.org/10.12724/ajss.32.1.

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The research on the impact of alcoholism on the family indicates that alcoholism often poses threat to the wellbeing of the family, the most affected ones being the other spouse and the children. Alcoholism often poses serious risk to the emotional, cognitive, behavioural, physical and social wellbeing of the abuser, the partner and the children. Most of the researches have explored the impact of parental alcoholism on the negative outcome on psychosocial development of partners and children, very few documented studies have been carried out on the positive aspects of life such as wellbeing and futuristic hope in the children of alcoholic parents (COA). This study attempts to explore the relationship and the difference between QOL and Hope in COA and children of non-alcoholics (CONA). The study was conducted on a sample of 60 children each between the age of 12 to 15 from alcoholics and non-alcoholic parents drawn from a district of Kerala using purposive sampling technique. The measures used were QOL-BREF by WHO (1996) and Children Hope Scale (CHS) by Snyder et al. (1996). The data was first analyzed using the descriptive statistics, the normality of the data was checked using Shapiro Wilk test, Mann-Whitney U test was used to find the difference between the COA and CONA on QOL and Hope. The relationship between the variables was assed using Spearman rank correlation. The results of the study indicate that there is significant difference in QOL among the children of alcoholics and non-alcoholics. The COA demonstrated comparatively less Hope than the CONA, however there was no significant difference among them. The QOL and Hope were correlated only among the CONA. The study has implication for positive intervention for the COA, parental and school based interventions such as preventive, remedial and holistic counselling or therapy.

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5

Vaillant, George E. "Alcoholics Anonymous: Cult or Cure?" Australian & New Zealand Journal of Psychiatry 39, no. 6 (June 2005): 431–36. http://dx.doi.org/10.1080/j.1440-1614.2005.01600.x.

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Objective: To discuss the mechanism of action, the efficacy and the safety of Alcoholics Anonymous (AA) in the treatment of alcoholism. Method: The published works on effective treatments for alcoholism is briefly reviewed and a prospective multidisciplinar y follow-up of recovery from alcoholism in two community cohorts of adolescent males followed from 1940 until the present day is reviewed. Conclusions: The suggested mechanism of action of AA is that it employs four factors widely shown to be effective in relapse prevention in addictions: external supervision, substitute dependency, new caring relationships and increased spirituality. In addition, AA serendipitously follows the principles of cognitive behaviour therapy in relapse prevention. Alcoholics Anonymous appears equal to or superior to conventional treatments for alcoholism, and the skepticism of some professionals regarding AA as a first rank treatment for alcoholism would appear to be unwarranted. Alcoholics Anonymous is probably without serious side-effects.

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6

&NA;. "Acamprosate Therapy for Alcoholism." Nurse Practitioner 30, no. 3 (March 2005): 62. http://dx.doi.org/10.1097/00006205-200503000-00014.

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7

Vastag, B. "Gene Therapy for Alcoholism?" JAMA: The Journal of the American Medical Association 286, no. 15 (October 17, 2001): 1829—a—1829. http://dx.doi.org/10.1001/jama.286.15.1829-a.

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8

Vastag, Brian. "Gene Therapy for Alcoholism?" JAMA 286, no. 15 (October 17, 2001): 1829. http://dx.doi.org/10.1001/jama.286.15.1829-jha10010-2-1.

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9

Bodrogi, Andrea. "Cognitive behavioural therapy of alcoholism." Magyar Pszichológiai Szemle 66, no. 1 (March 1, 2011): 141–56. http://dx.doi.org/10.1556/mpszle.66.2011.1.9.

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Jelen tanulmány az alkoholizmus gyógykezelésében alkalmazott számos irányzat közül a kognitív viselkedésterápiát mutatja be, általános érvényű azonban az a megállapítás, hogy a szenvedélybetegek pszichoterápiája komplex folyamat: több síkon, több módszer szerint megy végbe. Minden egyes kliens gyógykezelése egyéni sajátosságokat mutat, így a terápia is egyedi, mindig a kliens aktuális állapotához, motiváltsági fokához és szükségleteihez alkalmazkodik. Az alkoholfüggőség kognitív szempontú kezelésének másik jellegzetessége, hogy hosszú távú, nem időhatáros, és végső célja az absztinencia huzamos fenntartása mellett az optimális életminőség elérése.

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10

Lisansky Gomberg, Edith S., Belinda W. Nelson, and Bonnie F. Hatchett. "Women, alcoholism, and family therapy." Family & Community Health 13, no. 4 (January 1991): 61–71. http://dx.doi.org/10.1097/00003727-199101000-00008.

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11

Walle, Alf H. "Native Americans and Alcoholism Therapy." Journal of Ethnicity in Substance Abuse 3, no. 2 (October 27, 2004): 55–79. http://dx.doi.org/10.1300/j233v03n02_04.

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12

&NA;. "Possible alternatives in alcoholism therapy." Inpharma Weekly &NA;, no. 782 (April 1991): 3. http://dx.doi.org/10.2165/00128413-199107820-00006.

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13

O'Brien, P. "Parenteral vitamin therapy in alcoholism." Psychiatric Bulletin 19, no. 12 (December 1995): 788. http://dx.doi.org/10.1192/pb.19.12.788.

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14

Jones, A. W., L. Nilsson, S. A. Gladh, K. Karlsson, and J. Beck-Friis. "2,3-Butanediol in plasma from an alcoholic mistakenly identified as ethylene glycol by gas-chromatographic analysis." Clinical Chemistry 37, no. 8 (August 1, 1991): 1453–55. http://dx.doi.org/10.1093/clinchem/37.8.1453.

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Abstract 2,3-Butanediol was mistakenly identified as ethylene glycol in plasma specimens from two alcoholic patients. The cyclic phenylboronate ester derivatives of 2,3-butanediol and ethylene glycol had the same retention time when OV-17 was used as the stationary phase for gas chromatography. This led to incorrect diagnosis of ethylene glycol poisoning and unnecessary invasive therapy. Plasma from two chronic alcoholics contained 2,3-butanediol at 3.5 and 3.4 mmol/L. The elimination half-life of 2,3-butanediol was 3.9 days when ethanol was administered during therapy for suspected ethylene glycol poisoning. Low concentrations of 2,3-butanediol might be present in blood of chronic alcoholics as a result of a novel pathway of intermediary metabolism associated with some forms of alcoholism. However, a more likely explanation for fairly high concentrations of 2,3-butanediol is enzymatic production from 2-butanone. This ketone occurs in denatured alcohol preparations often consumed by alcoholics in Sweden.

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15

Belskaya, G. N., and E. V. Sakharova. "Alcoholic polyneuropathy. Clinical forms and pathogenetically based approaches to therapy." Meditsinskiy sovet = Medical Council, no. 10 (August 12, 2021): 94–99. http://dx.doi.org/10.21518/2079-701x-2021-10-94-99.

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The number of cases of alcoholism in Russia is gradually decreasing, but still significantly affects the overall health indicators of the population. One of its frequent complications is alcoholic polyneuropathy. The article deals with the pathogenetic mechanisms of the occurrence and development of the disease, its forms, classification, and clinical picture. The damage to the nervous system in patients with alcoholism depends on the frequency of alcohol consumption, the dose, the type of drinks that were consumed, malnutrition, genetic predisposition and individual characteristics that determine the level of alcohol dehydrogenase and aldehyde dehydrogenase. In the clinical picture, a toxic form of alcoholic polyneuropathy is currently distinguished, associated with the direct effect of toxic alcohol metabolites on somatic and autonomic nerve fibers, thiamine deficiency, resulting from a deficiency of B vitamins, and mixed forms. According to the rate of development of clinical manifestations, there are acute forms of alcoholic polyneuropathy (thiamine deficiency) and chronic forms (toxic). The article discusses the possibilities of diagnostics using modern instrumental and laboratory methods of research, primarily electroneuromyography. With the help of this method of investigation, in alcoholic polyneuropathy, signs of axonal damage are most often detected, and in the thiamine-deficient form, it is possible to determine signs of secondary demyelination. The authors emphasize the importance of differential diagnosis with other pathologies. The article highlights the current understanding of the main therapeutic strategies, treatment options for patients with alcoholic polyneuropathy. Therapy of patients suffering from alcoholic polyneuropathy includes refusal of alcohol abuse, normalization of nutrition, medication. For drug therapy, B vitamins and antioxidants are used. The drug with a recognized antioxidant effect is alpha-lipoic acid. A clinical case was analyzed on the basis of our own clinical observation of a mixed form of alcoholic polyneuropathy.

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16

Mann, K. F. "PL02-01 - Individualised therapy of alcoholism." European Psychiatry 27 (January 2012): 1. http://dx.doi.org/10.1016/s0924-9338(12)75661-4.

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17

Fawcett, J., D. C. Clark, R. D. Gibbons, C. A. Aagesen, V. D. Pisani, J. M. Tilkin, D. Sellers, and D. Stutzman. "Evaluation of lithium therapy for alcoholism." Journal of Clinical Psychopharmacology 5, no. 3 (June 1985): 178???179. http://dx.doi.org/10.1097/00004714-198506000-00019.

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18

Edwards, Martha E., and Peter Steinglass. "FAMILY THERAPY TREATMENT OUTCOMES FOR ALCOHOLISM." Journal of Marital and Family Therapy 21, no. 4 (October 1995): 475–509. http://dx.doi.org/10.1111/j.1752-0606.1995.tb00176.x.

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19

Dragisic-Labas, Sladjana. "Application of dyadic adjustment scale in the systemic family therapy for alcoholism." Sociologija 50, no. 3 (2008): 293–312. http://dx.doi.org/10.2298/soc0803293d.

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Conceptions about marriage with alcoholic relations (based on empirical and clinical research by domestic and foreign authors) are presented in the introductory part of the paper, followed by evaluations of marital (family) therapies and conclusions about its importance in treating alcoholism. The study has included 200 marital couples (husband-alcoholic) on therapy in three psychiatric institutions from Belgrade. Dyadic Adjustment Scale test has been applied, measuring (in three time points - on the beginning, in six months, and after one year of therapy) marital couple cohesion, satisfaction (with marital relations), emotional expression and consensus. The results show the existence of firm alcoholic marital system at the beginning of the treatment, with low consensus and high satisfaction, which has been deconstructing and changing over time and forming more functional (healthier) marital relationship. Couples (17) that self-excluded from the therapy in first two months have been compared with the sample of couples, which successfully completed the treatment. Differences (lower score on DAS) have been noted from the beginning - weaker marital dyad, in comparison to couples that completed the treatment. The results showed that system family (marital) therapy had influenced significant changes in marital relations - higher consensus, stronger emotional expression and cohesion, as well as satisfaction with non-alcoholic marital relations during one-year treatment.

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20

Moyers, Penelope A. "Neurocognition and Alcoholism:." Occupational Therapy In Health Care 8, no. 2-3 (January 1992): 87–115. http://dx.doi.org/10.1080/j003v08n02_05.

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21

Moyers, Penelope. "Neurocognition and Alcoholism:." Occupational Therapy In Health Care 8, no. 2 (December 22, 1992): 87–115. http://dx.doi.org/10.1300/j003v08n02_05.

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22

Mandic-Gajic, Gordana. "Possibility to predict the development of secondary depression in primary alcoholics during abstinence." Vojnosanitetski pregled 62, no. 11 (2005): 833–39. http://dx.doi.org/10.2298/vsp0511833m.

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Background/Aim. The relationship between alcoholism and depression is observed in clinical trials. The factors which could predict persistence of secondary depression after alcohol withdrawal are not enough explored on admission. The differences between depressed (DA) and non-depressed (NDA) alcoholics regarding the degrees of severity of withdrawal, severity of depression and the intensity of cognitive dysfunctions were explored on admission to investigate possibility of prediction of the development of secondary depression in alcoholics. Methods. A group of primary male alcoholics (n=86) was recruited during inpatient treatment. After 4 weeks alcoholics were divided in the DA group (n=43) and NDA (n=43) group according to the score on the Hamilton Depression Rating Scale (HAM-D). Clinical assessment of withdrawal, scoring on the Alcohol Dependency Severity Scale- ASD, and scoring on the Mini Mental Scale-MMSE were performed in all the participants on admission. The differences between the groups were tested by the Student's t-test. Results. The DA group showed the significantly higher severity of depression, higher levels of alcohol withdrawal symptoms and cognitive dysfunctions than the NDA group on admission. Conclusion. The specific group of depressive alcoholics was shown to be characterized by the higher severity of alcoholism and depression on admission, which could predict prolonged, secondary depression. Early detection and concurrent therapy of secondary depression could improve the treatment, and reduce the relapse of alcoholism.

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23

Cooke, EdD, CTRS, Colleen A. "Therapeutic recreation and the Twelve Steps." American Journal of Recreation Therapy 12, no. 3 (July 1, 2013): 17–24. http://dx.doi.org/10.5055/ajrt.2013.0049.

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This article focuses on the Twelve Steps of Alcoholics Anonymous, and specifically on how recreational therapists can aid the recovery process by providing interventions that facilitate the working of the steps. Little has been written about Twelve Step application in recreational therapy practice, thus the meaning and work of each of the steps is explained, along with suggestions for how recreational therapy services can be applied to aid the individual in the work toward recovery from alcoholism.

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24

de la Fuente, Juan-Ramón. "Lithium Therapy for Alcoholism: Further Study Assistance." Mayo Clinic Proceedings 64, no. 8 (August 1989): 1034. http://dx.doi.org/10.1016/s0025-6196(12)61234-8.

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25

Clarke, J. Christopher, and John Garcia. "Deranged Ingestion: Foundations of Therapy for Alcoholism." Australian Drug and Alcohol Review 5, no. 1 (January 1986): 21–27. http://dx.doi.org/10.1080/09595238680000051.

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26

O'Farrell, Timothy J. "Marital and family therapy in alcoholism treatment." Journal of Substance Abuse Treatment 6, no. 1 (January 1989): 23–29. http://dx.doi.org/10.1016/0740-5472(89)90016-0.

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27

Kienast, T., H. von Hoerner, S. Reiske, B. Renneberg, J. Wrase, and A. Heinz. "Dialectical Behavior Therapy for Inpatients with Borderline Personality Disorder and Concomitant Alcohol Dependence: Results of a Pilot Study." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70325-6.

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Purpose of study:Psychotherapy with patients suffering from borderline personality disorder (BPD) and concomitant alcoholism requires an integrative approach. Dialectical Behavioral Therapy (DBT) is an evaluated and effective program for patients with BPD, whereas behavior therapy, commitment therapy and self-help groups have all been found to be effective in the treatment of alcoholism. In this pilot study, we give an initial report of the concept and efficacy of an eight week inpatient therapy program integrating an evaluated therapy of alcoholism with standard DBT. The changes of symptoms were evaluated using the Borderline Symptom List (BSL), the European Addiction Severity Index (EuropASI), Lifetime Parasuicide Count (LPC), and Beck-Depression-Inventory.Findings:Five case reports were included. All show improvements in various subscores of BSL and EuropASI, and had a decrease in the LPC score.Summary:With this pilot study we test the efficacy of an extended DBT program for inpatients with BPD and alcoholism who failed outpatient treatment, and found significant improvements in the study in all outcome measures. This promising result points to the necessity for clinical trials that compare standard care with extended DBT in larger cohorts.

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28

O'Farrell, Timothy J., and Abigail Z. Schein. "Behavioral Couples Therapy for Alcoholism and Drug Abuse." Journal of Family Psychotherapy 22, no. 3 (July 2011): 193–215. http://dx.doi.org/10.1080/08975353.2011.602615.

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29

Halford, Kim. "Behavioural Couples Therapy for Alcoholism and Drug Abuse." Drug and Alcohol Review 28, no. 1 (January 16, 2009): 87–88. http://dx.doi.org/10.1111/j.1465-3362.2008.00013_1.x.

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30

O'Farrell, Timothy J., and William Fals-Stewart. "Behavioral couples therapy for alcoholism and drug abuse." Journal of Substance Abuse Treatment 18, no. 1 (January 2000): 51–54. http://dx.doi.org/10.1016/s0740-5472(99)00026-4.

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31

LESCH, O. M., and H. WALTER. "SUBTYPES OF ALCOHOLISM AND THEIR ROLE IN THERAPY." Alcohol and Alcoholism 31, supp1 (March 1, 1996): 63–67. http://dx.doi.org/10.1093/oxfordjournals.alcalc.a008221.

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32

Chick, Jonathan, and David J. Nutt. "Substitution therapy for alcoholism: time for a reappraisal?" Journal of Psychopharmacology 26, no. 2 (July 8, 2011): 205–12. http://dx.doi.org/10.1177/0269881111408463.

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33

James, M. R. "Music Therapy and Alcoholism: Part II--Treatment Services." Music Therapy Perspectives 5, no. 1 (January 1, 1988): 65–68. http://dx.doi.org/10.1093/mtp/5.1.65.

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34

Galanter, Marc, Ricardo Castameda, and Itamar Salamon. "Institutional Self-Help Therapy for Alcoholism: Clinical Outcome." Alcoholism: Clinical and Experimental Research 11, no. 5 (October 1987): 424–29. http://dx.doi.org/10.1111/j.1530-0277.1987.tb01916.x.

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35

Klostermann, Keith, William Fals-Stewart, Christie Gorman, Cheryl Kennedy, and Cynthia Stappenbeck. "Behavioral Couples Therapy for Alcoholism and Drug Abuse." Journal of Evidence-Based Social Work 2, no. 1-2 (May 9, 2005): 235–55. http://dx.doi.org/10.1300/j394v02n01_13.

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36

Buchbinder, Jay. "Gestalt Therapy and Its Application to Alcoholism Treatment." Alcoholism Treatment Quarterly 3, no. 3 (December 19, 1986): 49–67. http://dx.doi.org/10.1300/j020v03n03_05.

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37

Melo, Raquel Calvão de, Rui Lopes, and José Carlos Alves. "A Case of Psychosis in Disulfiram Treatment for Alcoholism." Case Reports in Psychiatry 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/561092.

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Background. Disulfiram, a drug used in the treatment of alcohol dependence, is an inhibitor of dopamine-β-hydroxylase causing an increase in the concentration of dopamine in the mesolimbic system. In addition to the physical symptoms associated with concomitant use of alcohol, disulfiram may lead to adverse events, when used alone, including psychosis.Aims. To report a case of a rare complication when using disulfiram for alcoholism treatment in a patient in alcoholic abstinence.Case Report. We describe the case of a 42-year-old male patient, who developed psychotic symptoms 3 weeks after initiating treatment with disulfiram for alcohol dependency. The patient had a history of chronic alcoholism for 12 years and was under disulfiram treatment (250 mg/day) for 1 month, with no other past history of psychiatric illness. The symptoms worsened after he initiated alcohol consumption, while taking disulfiram. The patient was hospitalized and disulfiram was suspended. After 4 days he was asymptomatic and at 6-week follow-up remained asymptomatic.Conclusion. Treatment with disulfiram can lead to the appearance of psychosis in patients with increased vulnerability. In clinical practice, psychosis in the context of alcoholism with disulfiram therapy is often neglected and should be taken into account.

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38

Faetz, Jacqueline. "Nutritional Therapy: The Missing Link to Treatment of Alcoholism." Journal of Addictions Nursing 10, no. 4 (1998): 197–200. http://dx.doi.org/10.3109/10884609809041811.

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39

Toneatto, Tony. "Couple therapy for alcoholism: A cognitive-behavioral treatment manual." Clinical Psychology Review 16, no. 8 (January 1996): 779–81. http://dx.doi.org/10.1016/s0272-7358(96)00037-2.

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40

Roukavichnikov, V. M. "The Complex Approach to the Antirelapse Therapy of Alcoholism." European Psychiatry 12, S2 (1997): 233s. http://dx.doi.org/10.1016/s0924-9338(97)80741-9.

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41

Condit, David. "Couple Therapy for Alcoholism: A Cognitive-Behavioral Treatment Manual." TCA Journal 24, no. 2 (September 1996): 60–61. http://dx.doi.org/10.1080/15564223.1996.12034485.

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42

Kinkulkina, M. A., and N. N. Ivanets. "TIANEPTINE IN THE MAINTENANCE THERAPY OF PATIENTS WITH ALCOHOLISM." Alcoholism: Clinical & Experimental Research 28, Supplement (August 2004): 51A. http://dx.doi.org/10.1097/00000374-200408002-00264.

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43

O'Farrell, Timothy J., and William Fals-Stewart. "Behavioral Couples Therapy for Alcoholism and Other Drug Abuse." Alcoholism Treatment Quarterly 26, no. 1-2 (March 3, 2008): 195–219. http://dx.doi.org/10.1300/j020v26n01_10.

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44

Flotte, Terence R. "Gene Therapy for Alcoholism and Other Substance Use Disorders." Human Gene Therapy 28, no. 9 (September 2017): 701–2. http://dx.doi.org/10.1089/hum.2017.29048.trf.

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45

Elkins, Ralph L. "Chemical aversion (emetic therapy) treatment of alcoholism: Further comments." Behaviour Research and Therapy 29, no. 5 (1991): 421–28. http://dx.doi.org/10.1016/0005-7967(91)90125-m.

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46

Davis, Nancyann H. "Dispensing and Prescribing Cautions for Medical Care During Recovery From Alcohol and Drug Addiction." Journal of Pharmacy Practice 4, no. 6 (December 1991): 362–68. http://dx.doi.org/10.1177/089719009100400605.

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Alcoholics and addicts who are recovering may find that prescription and nonprescription drugs can be stumbling blocks to recovery unless they have appropriate counseling and drug therapy management. Pharmacists can use their knowledge of pharmacy, pharmacology, and physiology to help patients avoid relapse to active alcoholism or addiction. They can serve as patient mediators with busy prescribers. In patient counseling, pharmacists can differentiate between passing and life-threatening symptoms, explain drug-free or drug-minimum alternatives, and generally supplement the tools and principles patients receive in their mutual support groups.

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47

Chaudhary, Rohit John, and Bharti Kwatra Uppal. "To Evaluate the Effect of Vitamin E Therapy on the Oxidative Stress Markers (Nitric Oxide, SOD, Glutathione Peroxidase) & Vitamin E Levels in Pulmonary Tuberculosis Patients." Journal of Evolution of Medical and Dental Sciences 9, no. 40 (October 5, 2020): 2970–75. http://dx.doi.org/10.14260/jemds/2020/651.

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BACKGROUND Severe oxidative stress has been reported in TB patients because of infection associated with malnutrition and poor immunity. Mycobacteria can induce reactive oxygen species (ROS) production by activating phagocytes, and enhanced ROS production may promote tissue injury and inflammation. We wanted to compare the effect of antioxidant administration in the outcome of ATT treatment between the test and the control group. METHODS This perspective study was conducted in the Departments of Biochemistry and Chest Medicine, CMC & Hospital. Hundred patients (fifty controls and fifty tests) who were diagnosed as pulmonary tuberculosis and started on DOT therapy under RNTCP during this period were included in the study. Each participant in the study was subjected to the following test at the first visit, 2nd month and 6th month follow up (biochemical markers Nitric oxide, SOD, Glutathione Peroxidase and Vitamin E levels). Statistical analysis was done using SPSS version. RESULTS The results were based on four categories (male / female, alcoholic / non-alcoholic, smoker / non-smoker, and younger / older age group). Females had responded better with greater fall in percentage of nitric oxide values (69 %) than males (64.1 %). The mean of SOD activity (277.5 + / - 31.5) was more in smokers than non-smokers (261.3 + / - 36.0) & percentage fall of nitric oxide in smokers (65 %) & non-smokers (67 %). In alcoholics the percentage fall of nitric oxide (68.3 %) was higher with more SOD activity (Mean 278.7 + / - 27.6) than non-alcoholics (Mean 256 + / - 38.0) indicating a positive correlation of smoking & alcoholism with tuberculosis. Younger age group responded better with more fall in the percentage of nitric oxide (67 %) & mean SOD activity (265.8 + / - 30.1) than older age group. CONCLUSIONS Antioxidant supplementation reduces oxidative stress, improves the effectiveness of ATT therapy, and thus helps in improving the outcome in pulmonary tuberculosis. KEY WORDS Pulmonary TB, ATT (Anti-Tubercular Treatment), Antioxidants & Free Radicals

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Farren, Conor K., Amir H. Rezvani, David Overstreet, and Stephanie O'Malley. "Combination Pharmacotherapy in Alcoholism: A Novel Treatment Approach." CNS Spectrums 5, no. 2 (February 2000): 70–76. http://dx.doi.org/10.1017/s1092852900012839.

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AbstractCombination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the majority have been limited to animal models. There is evidence to support a role for combination therapy in alcoholism. For example, several neurochemical systems, including the dopaminergic, serotonergic, and opioidergic, appear to affect alcohol intake. Studies in several different types of alcohol-preferring rats have suggested that coadministration of agents to target more than one of these systems simultaneously may produce beneficial effects on alcohol intake, while avoiding problematic effects, such as alterations in food or water intake. Data from preliminary clinical studies have shown trends toward combination therapy reducing alcohol intake in humans. While such findings are encouraging, they must be explored further in larger, randomized, double-blind trials.

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Kozarov, T., and B. Ivic. "Comorbiditet Social Phobia and Alcoholism." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70669-8.

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Alcoholism is the modern disease on the third place in modern society after cardiac and malignant disease. Social phobia is generally spread phobia (20-40%) people had some kind of fear and anxiety in most causal social activity. Examination has prepared on alcololic department SBB - G. Toponica. They have 44 beds, 38 males beds. From 38 males beds, we found 6 patients with social phobia (15,08%).Methods and results:It has been used WILLOU GHBY PERSONALITY SCHEDULE -all of them have been over fifty points which means that all of them have social phobia. They are curred with REMERON and TRITTICO and cognitiv behavior psycho therapy. REMERON has great success in secundary depression reduction. TRITTICO has great succes in anxiety reduction.

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Frueh, B. Christopher, Scott Henderson, and Hugh Myrick. "Telehealth service delivery for persons with alcoholism." Journal of Telemedicine and Telecare 11, no. 7 (October 2005): 372–75. http://dx.doi.org/10.1177/1357633x0501100701.

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Videoconferencing at a bandwidth of 384 kbit/s was used in open sessions for subjects with alcohol use disorders (AUD). Study participants received eight sessions of group therapy over a four-week period from an accredited addictions counsellor. Outcome assessment included self-report measures, a qualitative interview and a chart review. Of the 18 subjects who started the study, 14 attended at least four sessions of therapy, completed self-report assessments and the thematic interview. The participants reported high levels of satisfaction with telepsychiatry, found the intervention to be highly credible, had good session attendance and attrition comparable to that expected with conventional same-room treatment. In all, 82% of subjects reported that they would recommend the service to a friend or family member. The results demonstrate the feasibility of using videoconferencing for service delivery to adults with AUD, and encourage the future performance of randomized controlled trials.

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