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Relevant bibliographies by topics / Alcoholism Therapy

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Academic literature on the topic 'Alcoholism Therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Alcoholism Therapy"

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Baldwin, Jeffrey N., and Kathleen A. Kriegler. "Alcoholism Treatment: A Model of Abstinence-Oriented Care." Journal of Pharmacy Practice 4, no. 6 (December 1991): 351–56. http://dx.doi.org/10.1177/089719009100400603.

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Alcohol is the United States' foremost drug of abuse. Although a significant portion of the population continues to identify alcoholism with moral weakness, society embraces treatment as the primary mode of dealing with this disease. Treatment stressing ongoing abstinence from alcohol is the most universally accepted method of therapy. Following initial intervention and referral, treatment of the alcoholic includes detoxification; intensive early treatment, using either outpatient or inpatient treatment settings; and long-term support for recovery. Aftercare programs often require continuing attendance at Alcoholics Anonymous meetings, recovery support groups, and psychotherapy. In addition, recovering individuals may receive continued health care supervision from a physician knowledgeable about alcoholism. Family therapy is stressed as a component of recovery.

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Dragisic-Labas, Sladjana, and Gorica Djokic. "The importance of psychoeducation in systemic family therapy alcoholic treatment." Sociologija 52, no. 2 (2010): 197–210. http://dx.doi.org/10.2298/soc1002197d.

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The main goal of the paper was to analyze the impact of psychoeducation in alcoholism therapy treatment on initial motivation and comprehension, change in attitudes to alcoholism, and beginning of creating a new value system. The sample consisted of 166 respondents (83 married couples) that had been involved in one-year systemic group family therapy alcoholic treatment (with the man being alcoholic). A questionnaire on knowledge about alcoholism was used. The respondents were tested three times - at the beginning of the treatment, after 6 months, and after one year. The results showed that the level of education had increased through three phases of the treatment, that motivation changed from initial to substantial, that the comprehension had also changed, turning family system into a more functional model of living. Statistically significant difference in level of education between phase 1 and phase 3 of the family therapy was confirmed. In conclusion, the authors argue for the importance of psychoeducation as a method in treating alcoholism.

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ROGERS, HELEN. "Alcoholism." Australian Occupational Therapy Journal 6, no. 3 (August 27, 2010): 18–23. http://dx.doi.org/10.1111/j.1440-1630.1959.tb00828.x.

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Francis, Jini P., and Viju Painadath Devassy. "Setting the Children’s Teeth on Edge? The Influence of Parental Alcoholism on Children’s Wellbeing." Artha - Journal of Social Sciences 14, no. 1 (January 1, 2015): 1. http://dx.doi.org/10.12724/ajss.32.1.

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The research on the impact of alcoholism on the family indicates that alcoholism often poses threat to the wellbeing of the family, the most affected ones being the other spouse and the children. Alcoholism often poses serious risk to the emotional, cognitive, behavioural, physical and social wellbeing of the abuser, the partner and the children. Most of the researches have explored the impact of parental alcoholism on the negative outcome on psychosocial development of partners and children, very few documented studies have been carried out on the positive aspects of life such as wellbeing and futuristic hope in the children of alcoholic parents (COA). This study attempts to explore the relationship and the difference between QOL and Hope in COA and children of non-alcoholics (CONA). The study was conducted on a sample of 60 children each between the age of 12 to 15 from alcoholics and non-alcoholic parents drawn from a district of Kerala using purposive sampling technique. The measures used were QOL-BREF by WHO (1996) and Children Hope Scale (CHS) by Snyder et al. (1996). The data was first analyzed using the descriptive statistics, the normality of the data was checked using Shapiro Wilk test, Mann-Whitney U test was used to find the difference between the COA and CONA on QOL and Hope. The relationship between the variables was assed using Spearman rank correlation. The results of the study indicate that there is significant difference in QOL among the children of alcoholics and non-alcoholics. The COA demonstrated comparatively less Hope than the CONA, however there was no significant difference among them. The QOL and Hope were correlated only among the CONA. The study has implication for positive intervention for the COA, parental and school based interventions such as preventive, remedial and holistic counselling or therapy.

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Vaillant, George E. "Alcoholics Anonymous: Cult or Cure?" Australian & New Zealand Journal of Psychiatry 39, no. 6 (June 2005): 431–36. http://dx.doi.org/10.1080/j.1440-1614.2005.01600.x.

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Objective: To discuss the mechanism of action, the efficacy and the safety of Alcoholics Anonymous (AA) in the treatment of alcoholism. Method: The published works on effective treatments for alcoholism is briefly reviewed and a prospective multidisciplinar y follow-up of recovery from alcoholism in two community cohorts of adolescent males followed from 1940 until the present day is reviewed. Conclusions: The suggested mechanism of action of AA is that it employs four factors widely shown to be effective in relapse prevention in addictions: external supervision, substitute dependency, new caring relationships and increased spirituality. In addition, AA serendipitously follows the principles of cognitive behaviour therapy in relapse prevention. Alcoholics Anonymous appears equal to or superior to conventional treatments for alcoholism, and the skepticism of some professionals regarding AA as a first rank treatment for alcoholism would appear to be unwarranted. Alcoholics Anonymous is probably without serious side-effects.

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&NA;. "Acamprosate Therapy for Alcoholism." Nurse Practitioner 30, no. 3 (March 2005): 62. http://dx.doi.org/10.1097/00006205-200503000-00014.

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Vastag, B. "Gene Therapy for Alcoholism?" JAMA: The Journal of the American Medical Association 286, no. 15 (October 17, 2001): 1829—a—1829. http://dx.doi.org/10.1001/jama.286.15.1829-a.

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Vastag, Brian. "Gene Therapy for Alcoholism?" JAMA 286, no. 15 (October 17, 2001): 1829. http://dx.doi.org/10.1001/jama.286.15.1829-jha10010-2-1.

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Bodrogi, Andrea. "Cognitive behavioural therapy of alcoholism." Magyar Pszichológiai Szemle 66, no. 1 (March 1, 2011): 141–56. http://dx.doi.org/10.1556/mpszle.66.2011.1.9.

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Jelen tanulmány az alkoholizmus gyógykezelésében alkalmazott számos irányzat közül a kognitív viselkedésterápiát mutatja be, általános érvényű azonban az a megállapítás, hogy a szenvedélybetegek pszichoterápiája komplex folyamat: több síkon, több módszer szerint megy végbe. Minden egyes kliens gyógykezelése egyéni sajátosságokat mutat, így a terápia is egyedi, mindig a kliens aktuális állapotához, motiváltsági fokához és szükségleteihez alkalmazkodik. Az alkoholfüggőség kognitív szempontú kezelésének másik jellegzetessége, hogy hosszú távú, nem időhatáros, és végső célja az absztinencia huzamos fenntartása mellett az optimális életminőség elérése.

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Lisansky Gomberg, Edith S., Belinda W. Nelson, and Bonnie F. Hatchett. "Women, alcoholism, and family therapy." Family & Community Health 13, no. 4 (January 1991): 61–71. http://dx.doi.org/10.1097/00003727-199101000-00008.

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Dissertations / Theses on the topic "Alcoholism Therapy"

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Adams, Brett. "An experimental study of the role of an exercise programme in the treatment of alcoholism." Thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/25697.

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McMillan, C. L. "Differential assessment and treatment of alcoholism." Thesis, University of Ulster, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378672.

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Parker, Phyllis R. "Alcoholism, group therapy and self-esteem, residential group treatment in the North." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0034/MQ62489.pdf.

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Chadwick, R. M. "A comparative study of relevant talking in the group treatment of alcoholism." Thesis, University of Aberdeen, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372611.

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Dirks, Bryan Larry. "A follow up study of alcohol dependent patients following in patient treatment at the Avalon Treatment Centre." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/25880.

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This is a report of an investigation assessing outcome in a consecutive series of alcohol dependent patients admitted to the Avalon Treatment Centre from 21 October 1985 to 14 April 1986. Although extensive work has been done on the epidemiology of alcoholism among "coloured" people * [classified in terms of the population registration Act]. A direct result of the original field survey by Gillis, Keet and Slabbert was the establishment of this centre. A follow up study of people identified as having drinking problems in the original field survey showed that few people stopped drinking on their own account. Little is known about treatment outcome of patients hospitalized at this centre. Treatment at The Avalon Treatment Centre is based on therapeutic community principles, group therapy, family and social case work as well as the use of antabuse. Contact with Alcoholics Anonymous is encouraged during and after hospitalisation. In addition patients are also followed up by a community sister.

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Craig, Susanna D. "The effects of exercise on alcohol consumption and depression in DUI probationers." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-12162009-020232/.

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Hoffman-Konn, Lisa Denise. "Communal Coping in Couple Alcohol Treatment." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1262%5F1%5Fm.pdf&type=application/pdf.

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Rufus, Brett Charles. "Relapse prevention therapy: an integrated approach to the treatment of alcohol disorders and comorbid anxiety : a review of literature on anxiety, alcoholism and relapse prevention therapy - recommendations for clinical psychology groups conducted as part of an inpatient alcohol rehabilitation programme in the Western Cape." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/50078.

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Thesis (MA)--University of Stellenbosch, 2004.
ENGLISH ABSTRACT: Two recent local studies of relapse among individuals who had attended inpatient alcohol rehabilitation programmes in the Western Cape found relapse rates of up to 60%. A high incidence of comorbid anxiety, low self-efficacy and avoidant coping style were principal reasons cited for relapse. The following literary review was undertaken in an effort at better understanding current findings on the comorbid relationship between alcohol abuse/dependency and anxiety, and on dysfunctional coping styles and relapse. It also reviews current literature and theory concerning the treatment of alcoholics using the Relapse Prevention (RP) model of therapy. Based on these findings, recommendations are made for the application of RP to the clinical psychology groups run for alcohol abusing/dependent inpatients at Neuro Clinic D, Stikland Hospital, Western Cape. Relapse Prevention Therapy was selected because of its integrated approach to addressing both substance abuse and the inadequate coping styles that often render people vulnerable to anxiety, depression and relapse. It was also chosen because of the more constructive, less punitive approach it takes to substance dependence/abuse and the issue of lapses and relapse. The recommendations made in this review should not, in any way, be seen as criticism of the existing programme at Neuro Clinic D. They are, essentially, the individual reflections of the author based on the four months he spent conducting clinical psychology groups in the unit and the findings of two local studies that looked at some of the reasons for relapse following treatment in this and other local facilities. The specific focus on the groups run by clinical psychologists should also not be seen as ignoring the important and valuable work done by other professionals in the unit; notably those in psychiatry, nursing, social work, occupational therapy and pastoral care. On the contrary, information gathered by these professionals is vital to the team effort of rehabilitation, and the identification of psychosocial stressors and cognitive patterns that place people at risk of relapse.
AFRIKAANSE OPSOMMING: Twee onlangse plaaslike studies van terugvalonder pasiënte wat binnepasiëntalkoholrehabilitasieprogramme in die Weskaap bygewoon het, het terugvalkoerse van tot 60% gerapporteer. 'n Hoë voorkoms van komorbiede angs, lae sin van self-vermoë en 'n vermydende streshanteringstyl was die hoofredes aangevoer vir die terugval. Die volgende literatuur-oorsig is onderneem in 'n poging tot 'n beter begrip van huidige bevindinge oor die komorbiede verhouding tussen alkoholmisbruik/afhanklikheid en angs, en oor wanfunksionele streshanteringstyle en terugval. Die oorsig beskou ook huidige literatuur en teorie aangaande die behandeling van alkoholiste deur middel van die Relapse Prevention (RP) model (Terugvalvoorkomingsmodel) van terapie. Op grond van hierdie bevindinge word aanbevelings gemaak VIr die toepassing van RP op die kliniese-sielkundegroepe aangebied VIr alkoholmisbruikende/afhanklike binnepasiënte by Neurokliniek D, Stiklandhospitaal, Weskaap. RP is gekies op grond van sy geïntegreerde benadering tot beide substansmisbruik en die onvoldoende streshanteringstyle wat dikwels mense kwesbaar maak vir angs, depressie en terugval. Die model is ook gekies as gevolg van die meer konstruktiewe, minder strafgerigte benadering tot substansafhanklikheid/misbruik en tot val en terugval. Die aanbevelings in hierdie oorsig moet in geen opsig beskou word as kritiek op die bestaande programme in Neurokliniek D nie. Hulle is, in wese, die individuele gevolgtrekkings van die skrywer gebaseer op sy vier maande ondervinding met sielkundegroepe in die eenheid en op die bevindinge van twee plaaslike studies wat ondersoek ingestel het na sommige van die redes vir terugval na behandeling in hierdie en ander plaaslike fasiliteite. Die spesifieke fokus op die groepe wat deur kliniese sielkundiges bestuur word moet ook nie gesien word as 'n geringskatting van die belangrike werk van ander professionele mense in die eenheid nie, in die besonder dié in psigiatrie, verpleging, maatskaplike werk, arbeidsterapie and pastorale sorg. In teendeel, inligting ingesamel deur hierdie mense is lewensbelangrik vir die spanpoging van rehabilitasie, en vir die identifisering van psigo-sosiale stressors en kognitiewe patrone wat pasiënte vatbaar maak vir terugval.

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Ermann, Lauren Sheli. "The Lived Experiences of Older Women in Alcoholics Anonymous." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51176.

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The purpose of this study was to describe, analyze, and better understand the lived experiences of women age 50 and older in Alcoholics Anonymous (AA). Guiding this inquiry were the following research questions: 1) How do the older women participants experience the AA program? 2) What aspects of AA do older women consider beneficial? 3) What aspects of AA do older women consider detrimental? 4) What do older women consider as important conditions to succeed in the AA program? 5) How did these older women elicit meaning in their involvement with AA? and 6) How was the narrative aspect of AA experienced by the participants?
Fourteen older women from AA meetings in Southwest Virginia participated in two qualitative interviews. The results were represented by narrative descriptions of each participant\'s experiences and analyzed for common themes across the stories, which were presented and discussed. For these participants, the AA program was found to intersect with narrative therapy. AA, like narrative therapy, highlights deconstructing and re-authoring life stories through personal narratives. Storytelling itself proved to be among the most important traditions of AA and a core benefit to the storyteller (and to a lesser extent, the listener). Study participants found that telling their stories allowed for 1) a way to give back to the program, 2) a feeling of belonging to the group, 3) a welcome reminder to the speaker of her past struggles with alcoholism, and 4) a spiritual experience. Many of the women articulated their early concerns with publicly sharing at meetings, as well as their ongoing considerations of boundaries, over-sharing, and conflicts of interest in storytelling. Finally, in an unexpected finding, the women cultivated and maintained intimate friendships with other women in AA that addressed relevant issues beyond sobriety including everyday needs and life challenges. Social activities often transcended the boundaries of the meetings.

Ph. D.

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Cornwall, Jane. "Alcohol dependence and avoidant attachment : implications for therapy." Thesis, University of Wolverhampton, 2007. http://hdl.handle.net/2436/14641.

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The literature review revealed co-morbidity between adverse childhood experiences, adult psychopathology and alcohol dependence, although causality was questionable due to multiple variables. The current study used 54 clients at the acute end of the spectrum of severe alcohol dependence from a specialist tertiary substance misuse service (clients) and a control group of 54 non-problematic drinkers from an NHS working population (controls) to examine possible differences in security of attachment and maladaptive schemas and investigated how early relational experiences influenced core beliefs regarding self, others and intimate relationships and therapeutic implications for severely alcohol dependent clients’ engagement in specialist services. The study was divided into two sections: (1) quantitative analysis using Feeney, Noller and Hanrahan’s (1994) Attachment Style Questionnaire to measure attachment style and Young’s Schema Questionnaire (Young & Brown, 2001) to measure maladaptive schemas in the domain of disconnection and rejection and (2) qualitative analysis, using Interpretational Phenomenological Analysis (IPA) to explore eight severely alcohol dependent clients’ subjective experiences of intimate relationships. Clients scored significantly lower in secure attachment style and significantly higher in both avoidant and ambivalent attachment style than controls and suggested overlapping between the two dimensions, known as ‘fearful avoidant’ attachment. Clients scored significantly higher than controls in all five sub-categories of maladaptive schemas in the domain of disconnection and rejection, namely mistrust/abuse, emotional deprivation, abandonment, social isolation/alienation and defectiveness/shame. IPA revealed common themes of negative parent-child interaction: physical and psychological abuse, neglect and explicit maternal rejection and emotional deprivation and hostile and abusive parent-parent interaction. These aetiological factors influenced fearful avoidant attachment and maladaptive core beliefs. Negation of children’s needs implicated an immaturely developed diffuseness of identity and defective self that inhibited formation of intimate adult relationships. A bio-psychosocial explanation suggested alcohol ameliorated hyper-vigilant anxiety and depression from adverse childhood experiences within a threatening family environment that implicated insecure attachment, maladaptive core beliefs and negative self-identity, inhibiting emotional intimacy. It advocated screening procedures and an integrated CBT and schema-based therapeutic approach for those at the more severe end of the spectrum of alcohol dependence deemed at risk of not engaging or disengaging prematurely from services.

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Books on the topic "Alcoholism Therapy"

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Denzin, Norman K. Treating alcoholism: An Alcoholics Anonymous approach. Newbury Park, Calif: Sage Publications, 1987.

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Denzin, Norman K. Treating alcoholism: An Alcoholics Anonymous approach. Newbury Park, Calif: Sage Publications, 1987.

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Cierpiałkowska, Lidia. Alcoholism: Self-help groups and professional therapy. Delft: Eburon Publisher, 1994.

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Perkinson, Robert R. Treating Alcoholism. New York: John Wiley & Sons, Ltd., 2004.

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Lindström, Lars. Managing alcoholism: Matching clients to treatment. Oxford: Oxford University Press, 1992.

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Counselling for alcohol problems. 2nd ed. London: SAGE Publications, 2001.

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Velleman, Richard. Counselling for alcohol problems. London: SAGE Publications, 1992.

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Davis, Donald I. Alcoholism treatment: An integrative family and individual approach. New York: Gardner, 1987.

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The diagnosis and treatment of alcoholism. 2nd ed. Northvale, N.J: J. Aronson, 1994.

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Introduction to alcoholism counseling: A bio-psycho-social approach. 2nd ed. Washington, D.C: Taylor & Francis, 1995.

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Book chapters on the topic "Alcoholism Therapy"

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Brady, Roscoe O. "Potential gene therapy for alcoholism." In Toward a Molecular Basis of Alcohol Use and Abuse, 383–93. Basel: Birkhäuser Basel, 1994. http://dx.doi.org/10.1007/978-3-0348-7330-7_38.

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Clark, David C., and Jan Fawcett. "Does Lithium Carbonate Therapy for Alcoholism Deter Relapse Drinking?" In Recent Developments in Alcoholism, 315–28. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4899-1678-5_16.

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Buzel, Alita. "Equine-Assisted Mental Health Therapy and Alcoholism." In Equine-Assisted Mental Health Interventions, 155–60. New York: Routledge, 2019.: Routledge, 2018. http://dx.doi.org/10.4324/9781315164144-15.

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Gacić, Branko. "Socio-Cultural Variables in Family Therapy of Alcoholism." In Psychiatry The State of the Art, 613–17. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4757-1853-9_97.

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O’Farrell, Timothy J. "Couples Therapy in Treatment of Alcoholism and Drug Abuse." In Textbook of Addiction Treatment: International Perspectives, 907–25. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5322-9_44.

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Klostermann, Keith, and Timothy J. O’Farrell. "Couple and Family Therapy in Treatment of Alcoholism and Drug Abuse." In Textbook of Addiction Treatment, 447–58. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36391-8_31.

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Roussaux, J. P. "Family Therapy of Alcoholism: An Evaluation of Its Efficiency as a Predetoxification Move." In Psychological Treatment of Mental Illness, 103–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72540-1_8.

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Jacobus-Kantor, Laura, and James G. Emshoff. "Play Therapy for Children of Alcoholics." In School-Based Play Therapy, 331–57. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118269701.ch16.

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Cooper-Sadlo, Shannon, and Jessica L. Chou. "Alcoholics Anonymous, 12-Step Programs." In Encyclopedia of Couple and Family Therapy, 1–4. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-15877-8_581-1.

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Chou, Jessica L., and Bertranna A. Muruthi. "Adult Child of Alcoholics (ACOA)." In Encyclopedia of Couple and Family Therapy, 1–4. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-15877-8_582-1.

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Conference papers on the topic "Alcoholism Therapy"

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Uthayasangar, R., and P. Wimalaratne. "Towards Virtual Therapy for Alcoholic Depression." In 2013 Fourth International Conference on Intelligent Systems, Modelling and Simulation (ISMS 2013). IEEE, 2013. http://dx.doi.org/10.1109/isms.2013.62.

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Trushkova, Victoria Vladimirovna, and Yuri Vladimirovich Shikhovtsov. "INFLUENCE OF PHYSICAL LOAD ON THE MORAL APPEARANCE OF A STUDENT." In Russian science: actual researches and developments. Samara State University of Economics, 2020. http://dx.doi.org/10.46554/russian.science-2020.03-1-584/587.

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The article analyzes the beneficial effects of physical activity on the student’s moral character, identifies related problems, ways to solve them and the role of the state in shaping the student’s moral character in order to attract them to daily sports, choose sports as a way of life, thereby reducing the risk of drug addiction and alcoholism.

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Leone, V., E. Kotsiliti, I. Singh, X. Li, A. Ali, S. Gallage, D. Pfister, et al. "Antioxidant-based therapy in non-alcoholic steatohepatitis (NASH) and NASH-induced hepatocellular carcinoma development." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402195.

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Liu, Tao, Qiu-Ling Xu, Tao Sun, Dong-Mei Zhao, and Zhen-Guo Wang. "The TCM therapy of spleen-strengthening and dampness-removing and non-alcoholic fatty liver." In 2019 INTERNATIONAL CONFERENCE ON BIOTECHNOLOGY AND BIOENGINEERING (9th ICBB). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0020820.

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Hohmann, N., WE Haefeli, S. Mueller, H. Seitz, F. Schröder, H. Teng, B. Moreira, and T. Bruckner. "Clomethiazole improves alcoholic fatty liver in patients admitted to the hospital for alcohol detoxification therapy." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402136.

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Griffiths, Joshua, and Amer Al-Joudeh. "PTH-092 N-acetylcysteine and prednisolone combination therapy in severe alcoholic hepatitis, an NHS teaching hospital pilot study." In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.248.

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Lefrère, J. J., D. Gozin, J. P. Soulier, P. Mavier, L. Bettan, and D. Dhumeaux. "SPECIFICITY OF INCREASED DES-GAMMA-CARBOXYPROTHROMBIN AS A MARKER OF HEPATOCELLULAR CARCINOMA AFTER VITAMIN K INJECTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644319.

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An elevation of des-gamma-carboxyprothrombin (DCP) has been observed in about 70 % of cases of hepatocellular carcinoma (HCC). Howewer, an increased DCP is not specific of HCC. Oral anticoagulant therapy increases the DCP level by preventing the gamma-carboxylation of prothrombin : thereafter an increased DCP can not be used as an HCC marker before three weeks have elapsed after stopping anti vitamin K therapy. Furthermore, since vitamin K is necessary for the gamma-carboxylation of vitamin K dependent factors, a vitamin K deficiency increases the DCP level long before the modification of the prothrombin time. It is thus imperative to eliminate an underlying vitamin K deficiency before attributing an increased DCP to a HCC. We used a method of DCP assay using staphylocoagulase. We studied the effect of an intravenous injection of 20 mg of vitamin K1 on DCP level in 7 patients with histologically proven HCC and in 10 patients with various disorders (5 alcoholic cirrhosis, 1 chronic hepatitis, 4 pancreatic cancer). All these 17 patients had increased DCP before vitamin K injection. In a second sampling obtained 15 days or more after injection, only the 7 patients with HCC kept increased DCP level. In patients of both categories in whom we obtained intermediary samplings, we observed that the DCP level decreased In all cases. The normalisation of the DCP level was lasting only in those patients without HCC, confirming the hypothesis of an underlying vitamin K deficiency ; this decrease was very transitory in those patients with HCC, suggesting that the elevated DCP came from a yet unexplained (but not linked to a vitamin K deficiency) mechanism. We may conclude that an increased DCP level 15 days after vitamin K injection may constitute a specific marker of HCC.

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