Journal articles: 'AK'

1

Jeschke, Gundula. "AK Ausbildung." Practical Metallography 46, no. 12 (December 2009): 670. http://dx.doi.org/10.3139/147.091204.

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2

Huan, L. C., and S. Rong. "AK-2123." Drugs of the Future 20, no. 7 (1995): 659. http://dx.doi.org/10.1358/dof.1995.020.07.300778.

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3

Frede, Dov. "Test article AK." Journal of Test Deposits 34, no. 1 (September 1, 2010): 38. http://dx.doi.org/10.5555/test_201010041211.

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4

Lenz, Barbara. "AK Verkehr Page." Journal of Transport Geography 18, no. 4 (July 2010): 588–89. http://dx.doi.org/10.1016/j.jtrangeo.2010.03.020.

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5

Rothfuß, Rainer, and Jessica Le Bris. "AK Verkehr page." Journal of Transport Geography 23 (July 2012): 97–98. http://dx.doi.org/10.1016/j.jtrangeo.2012.04.016.

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6

Le Bris, Jessica, Annika Busch-Geertsema, and Cordula Neiberger. "AK Verkehr page." Journal of Transport Geography 30 (June 2013): 248–49. http://dx.doi.org/10.1016/j.jtrangeo.2013.04.002.

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7

Scheiner, Joachim. "AK Verkehr page." Journal of Transport Geography 37 (May 2014): 121–22. http://dx.doi.org/10.1016/j.jtrangeo.2014.04.010.

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8

Scheiner, Joachim, and Mathes Wilde. "AK Verkehr Page." Journal of Transport Geography 45 (May 2015): 85. http://dx.doi.org/10.1016/j.jtrangeo.2015.04.001.

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9

de Assis, Altair S., Siegbert Kuhn, and Juan A. Limaco. "The AK Transform." Applied Mathematics 08, no. 02 (2017): 145–53. http://dx.doi.org/10.4236/am.2017.82012.

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10

Bisht, Satpal S., and Amrita K. Panda. "Biochemical Characterization and 16S rRNA Sequencing of Few Lipase-Producing Thermophilic Bacteria from Taptapani Hot Water Spring, Orissa, India." Biotechnology Research International 2011 (April 14, 2011): 1–5. http://dx.doi.org/10.4061/2011/452710.

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Three lipase-producing thermophilic bacteria (AK-P1, AK-P2, and AK-P3) were isolated from the Taptapani hot water spring in Orissa, India. The crude extra cellular lipases from cell-free culture supernatant were reacted in an olive oil mixture, and their lipolytic activities were compared. Identification of the bacteria was carried out using biochemical tests, 16SrRNA sequencing and sequences submitted to NCBI GenBank. Strain AK-P3, exhibited the highest lipolytic activity of 5.5 U/mL was identified as Porphyrobacter sp. The lipolytic activities of strains AK-P1 and AK-P 2 were 4.5 U/mL and 3.5 U/mL, respectively. Strains AK-P1 and AK-P2 were identified as Acinetobacter sp. and Brevibacillus spp. The GenBank accession numbers of the 16S rRNA gene sequences determined in this study for the strains AK-P1, AK-P2, and AK-P3 are HM359120, HM359119, and HM359118, respectively.

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11

Wang, Liyang, Angxuan Chen, Yan Zhang, Xiaoya Wang, Yu Zhang, Qun Shen, and Yong Xue. "AK-DL: A Shallow Neural Network Model for Diagnosing Actinic Keratosis with Better Performance than Deep Neural Networks." Diagnostics 10, no. 4 (April 13, 2020): 217. http://dx.doi.org/10.3390/diagnostics10040217.

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Actinic keratosis (AK) is one of the most common precancerous skin lesions, which is easily confused with benign keratosis (BK). At present, the diagnosis of AK mainly depends on histopathological examination, and ignorance can easily occur in the early stage, thus missing the opportunity for treatment. In this study, we designed a shallow convolutional neural network (CNN) named actinic keratosis deep learning (AK-DL) and further developed an intelligent diagnostic system for AK based on the iOS platform. After data preprocessing, the AK-DL model was trained and tested with AK and BK images from dataset HAM10000. We further compared it with mainstream deep CNN models, such as AlexNet, GoogLeNet, and ResNet, as well as traditional medical image processing algorithms. Our results showed that the performance of AK-DL was better than the mainstream deep CNN models and traditional medical image processing algorithms based on the AK dataset. The recognition accuracy of AK-DL was 0.925, the area under the receiver operating characteristic curve (AUC) was 0.887, and the training time was only 123.0 s. An iOS app of intelligent diagnostic system was developed based on the AK-DL model for accurate and automatic diagnosis of AK. Our results indicate that it is better to employ a shallow CNN in the recognition of AK.

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12

Lachant, NA, CR Zerez, J. Barredo, DW Lee, SM Savely, and KR Tanaka. "Hereditary erythrocyte adenylate kinase deficiency: a defect of multiple phosphotransferases?" Blood 77, no. 12 (June 15, 1991): 2774–84. http://dx.doi.org/10.1182/blood.v77.12.2774.2774.

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Abstract Adenylate kinase (AK) modulates the interconversion of adenine nucleotides (AMP + adenosine triphosphate----2 ADP). We evaluated the fifth kindred with hereditary erythrocyte (RBC) AK deficiency. The proband had chronic hemolytic anemia. Her RBC had undetectable AK activity when measured spectrophotometrically, whereas those of her parents had half-normal AK activity. AK electrophoresis showed only AK- 1 in the parents. The activities of pyruvate kinase and phosphoribosylpyrophosphate synthetase were decreased given the young age of the proband's RBC. Despite the absence of spectrophotometric AK activity, the proband's RBC were able to incorporate 14C-adenine into 14C-adenine nucleotides at 50% of the rate expected for her young RBC population, suggesting the possibility of an alternative pathway for the formation of ADP from AMP. Normal hemolysate had AMP:guanosine triphosphate (GTP) phosphotransferase activity, which produced ADP at 8% to 9% of the rate of AK (6.8 +/- 0.8 IU/mL RBC). AMP:GTP phosphotransferase activity was not detectable in the proband's or parent's hemolysates. These additional biochemical defects in the AK- deficient RBC further support the concept that AK deficiency per se may not cause hemolytic anemia. We propose that defects occur in multiple phosphotransferases in the AK-deficient RBC and that these other biochemical defects may produce deleterious lesions that promote the shortened RBC survival in AK deficiency.

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13

Lachant, NA, CR Zerez, J. Barredo, DW Lee, SM Savely, and KR Tanaka. "Hereditary erythrocyte adenylate kinase deficiency: a defect of multiple phosphotransferases?" Blood 77, no. 12 (June 15, 1991): 2774–84. http://dx.doi.org/10.1182/blood.v77.12.2774.bloodjournal77122774.

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Adenylate kinase (AK) modulates the interconversion of adenine nucleotides (AMP + adenosine triphosphate----2 ADP). We evaluated the fifth kindred with hereditary erythrocyte (RBC) AK deficiency. The proband had chronic hemolytic anemia. Her RBC had undetectable AK activity when measured spectrophotometrically, whereas those of her parents had half-normal AK activity. AK electrophoresis showed only AK- 1 in the parents. The activities of pyruvate kinase and phosphoribosylpyrophosphate synthetase were decreased given the young age of the proband's RBC. Despite the absence of spectrophotometric AK activity, the proband's RBC were able to incorporate 14C-adenine into 14C-adenine nucleotides at 50% of the rate expected for her young RBC population, suggesting the possibility of an alternative pathway for the formation of ADP from AMP. Normal hemolysate had AMP:guanosine triphosphate (GTP) phosphotransferase activity, which produced ADP at 8% to 9% of the rate of AK (6.8 +/- 0.8 IU/mL RBC). AMP:GTP phosphotransferase activity was not detectable in the proband's or parent's hemolysates. These additional biochemical defects in the AK- deficient RBC further support the concept that AK deficiency per se may not cause hemolytic anemia. We propose that defects occur in multiple phosphotransferases in the AK-deficient RBC and that these other biochemical defects may produce deleterious lesions that promote the shortened RBC survival in AK deficiency.

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14

Braun-Falco, Markus. "Hohe Prävalenz aktinischer Keratosen schon bei über 30-Jährigen." Kompass Dermatologie 7, no. 1 (2019): 18–19. http://dx.doi.org/10.1159/000495951.

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Background: Most of the data concerning the prevalence of actinic keratosis (AK) originate from the USA and Australia, and recently from Austria and Spain, but are based on populations in dermatology practices. Switzerland is the leading country with skin cancer incidence in Europe. AK prevalence among the Swiss population is therefore an important public health issue. Objective: To assess the prevalence of AK in the outpatient Swiss population in general practice. Methods: General practitioners captured AK diagnosis stage and localization in consecutive patients, who attended the physician for any reason. Results: A total of 2,844 consecutive patients (55.7% female) were enrolled in 59 general practitioners' offices. AK prevalence was 25.3% and increased steadily with age; 33% of men and 19% of women were diagnosed with AK. Every second AK patient declared leisure-related UV exposure, while only 23% were exposed to UV occupationally; 16% of the patients were UV exposed both occupationally and during leisure. AK distribution among sun-exposed body sites and extent of disease varied by sex. Conclusion: In Switzerland AK is a common diagnosis in dermatology practices. Since up to 5% of AK may progress to invasive squamous cell carcinoma (SCC), prevention of AK, as well as education of patients and general practitioners, may play a critical role for subsequent SCC development. This is the first study on AK prevalence in Switzerland identifying patients most affected by AK. These results will help to define future approaches to target general practitioners for education, screening, and specific intervention in patients with AK.

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15

Dziunycz, Piotr J., Elisabeth Schuller, and Günther F. L. Hofbauer. "Prevalence of Actinic Keratosis in Patients Attending General Practitioners in Switzerland." Dermatology 234, no. 5-6 (2018): 214–19. http://dx.doi.org/10.1159/000491820.

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Background: Most of the data concerning the prevalence of actinic keratosis (AK) originate from the USA and Australia, and recently from Austria and Spain, but are based on populations in dermatology practices. Switzerland is the leading country with skin cancer incidence in Europe. AK prevalence among the Swiss population is therefore an important public health issue. Objective: To assess the prevalence of AK in the outpatient Swiss population in general practice. Methods: General practitioners captured AK diagnosis stage and localization in consecutive patients, who attended the physician for any reason. Results: A total of 2,844 consecutive patients (55.7% female) were enrolled in 59 general practitioners’ offices. AK prevalence was 25.3% and increased steadily with age; 33% of men and 19% of women were diagnosed with AK. Every second AK patient declared leisure-related UV exposure, while only 23% were exposed to UV occupationally; 16% of the patients were UV exposed both occupationally and during leisure. AK distribution among sun-exposed body sites and extent of disease varied by sex. Conclusion: In Switzerland AK is a common diagnosis in dermatology practices. Since up to 5% of AK may progress to invasive squamous cell carcinoma (SCC), prevention of AK, as well as education of patients and general practitioners, may play a critical role for subsequent SCC development. This is the first study on AK prevalence in Switzerland identifying patients most affected by AK. These results will help to define future approaches to target general practitioners for education, screening, and specific intervention in patients with AK.

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16

Chow, Andrew, Darek Czokajlo, Joseph M. Patt, and Mamoudou Sétamou. "Development and Field Validation of a Beta-cyfluthrin-Based ‘Attract-and-Kill’ Device for Suppression of Asian Citrus Psyllid (Hemiptera: Liviidae) on Residential Citrus." Journal of Economic Entomology 112, no. 6 (August 15, 2019): 2824–32. http://dx.doi.org/10.1093/jee/toz221.

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Abstract An ‘attract-and-kill’ (AK) device was evaluated for suppression of adult Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), on residential citrus. The AK device, made from weather-resistant plasticized PVC, lured D. citri adults by simulating the color of citrus flush and killed them with beta-cyfluthrin. This study evaluated: 1) lethality of AK devices weathered up to 8 wk on residential citrus; 2) survival of psyllids caged with potted plants and AK devices; 3) psyllid suppression achieved by AK devices on individual dooryard trees. AK devices weathered for up to 8 wk remained lethal to psyllids. Greenhouse trials evaluated survival of adult psyllids caged for 4 d with orange jasmine plants that were: 1) treated with an (beta-cyfluthrin-infused) AK device; 2) treated with a blank (no insecticide) AK device; or 3) ‘untreated’ with no AK device. After 4 d, psyllid survival was on average 95% lower among adults exposed to plants with AK devices than adults exposed to untreated plants or plants with blank AK devices. Less than half of the adults exposed to plants with AK devices were alive after 1 d and nearly all were dead after 4 d. Deployment of 20 AK devices per tree provided significant psyllid suppression on infested lemon trees from winter to summer and reduced mean reproduction (cumulative eggs) by 91% and mean attack intensity (cumulative psyllid-days) of adults by 59% and nymphs by 53%. AK devices could be an effective control option for D. citri in urban areas.

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17

Winter, Thomas. "Öffentliche Gemeinschaftssitzung des AK Krankenhaushygiene und des AK Dokumentation und Statistik." Zeitschrift für Orthopädie und ihre Grenzgebiete 127, no. 04 (March 18, 2008): 427. http://dx.doi.org/10.1055/s-2008-1044694.

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18

DeGraff, Michel. "Flore Zéphir nan entèvyou ak Michel DeGraff ansanm ak Jacques Pierre." Journal of Haitian Studies 24, no. 2 (2018): 133–42. http://dx.doi.org/10.1353/jhs.2018.0021.

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19

Singh, Neha, Melissa M. Kendall, Yitai Liu, and David R. Boone. "Isolation and characterization of methylotrophic methanogens from anoxic marine sediments in Skan Bay, Alaska: description of Methanococcoides alaskense sp. nov., and emended description of Methanosarcina baltica." International Journal of Systematic and Evolutionary Microbiology 55, no. 6 (November 1, 2005): 2531–38. http://dx.doi.org/10.1099/ijs.0.63886-0.

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Three novel strains of methylotrophic methanogens were isolated from Skan Bay, Alaska, by using anaerobic cultivation techniques. The water was 65 m deep at the sampling site. Strains AK-4 (=OCM 774), AK-5T (=OCM 775T=DSM 17273T) and AK-9 (=OCM 793) were isolated from the sulfate-reducing zone of the sediments. Each of the strains was a non-motile coccus and occurred singly. Cells grew with trimethylamine as a catabolic substrate and strain AK-4 could also catabolize methanol. Yeast extract and trypticase peptones were not required for growth, but their addition to the culture medium slightly stimulated growth. Each of the strains grew at temperatures of 5–28 °C; they were slight halophiles and grew fastest in the neutral pH range. Analysis of the 16S rRNA gene sequences indicated that strain AK-4 was most closely related to Methanosarcina baltica. DNA–DNA hybridization studies showed 88 % relatedness, suggesting that strain AK-4 represents a novel strain within this species. Strains AK-5T and AK-9 had identical 16S rRNA gene sequences that were most closely related to the sequence of Methanococcoides burtonii (99·8 % sequence similarity). DNA–DNA hybridization studies showed that strains AK-5T and AK-9 are members of the same species (88 % relatedness value), but strain AK-5T had a DNA–DNA relatedness value of only 55 % to Methanococcoides burtonii. This indicates that strains AK-5T and AK-9 should be considered as members of a novel species in the genus Methanococcoides. We propose the name Methanococcoides alaskense sp. nov., with strain AK-5T (=OCM 775T=DSM 17273T) as the type strain.

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Buerstedde, J. M., L. R. Pease, A. E. Nilson, M. P. Bell, C. Chase, G. Buerstedde, and D. J. McKean. "Regulation of murine MHC class II molecule expression. Identification of A beta residues responsible for allele-specific cell surface expression." Journal of Experimental Medicine 168, no. 3 (September 1, 1988): 823–37. http://dx.doi.org/10.1084/jem.168.3.823.

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A panel of mutant class II genes have been constructed using site-directed mutagenesis and DNA-mediated gene transfer. Using this technique, Ak beta polypeptides have been altered by substituting one or more Ad beta-specific residues at polymorphic positions in the beta 1 domain. Transfection of M12.C3 B lymphoma cells with most mutant Ak beta* genes results in the expression of Ak beta* Ad alpha molecules on the cell surface. However, the substitution of a single d allele residue at position 78 or 86 in the Ak beta polypeptide results in either the complete absence or very low levels, respectively, of cell surface expression of the Ak beta* Ad alpha molecule, but does not alter Ak beta* Ak alpha expression. The T.86 Ak beta* Ad alpha is expressed primarily in an intracellular compartment while the T.78 Ak beta* molecule does not appear to be produced. The core-glycosylated T.78 Ak beta* polypeptide does, however, form a complex intracellularly with the core-glycosylated Ii polypeptide. Substitution of the combination of d allele residues at Ak beta polymorphic positions 9, 12, 13, 14, and 17 results in the absence of Ak beta* Ak alpha cell surface expression but does not alter the expression of this mutant Ak beta* polypeptide with the Ad alpha polypeptide. These allele-specific expression mutants demonstrate that substitution at certain beta 1 domain positions may result in the alteration of Ia cell surface expression and that the transport of Ia molecules from the Golgi apparatus to the cell surface may be regulated by signals that are determined by the interaction of polymorphic residues in both the alpha and beta polypeptides.

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21

Tegetmeyer, Helmut, and Andreas Merkenschlager. "Myelin-Oligodendrozyten-Glykoprotein-Antikörper bei Neuritis nervi optici im Kindesalter." Klinische Monatsblätter für Augenheilkunde 234, no. 10 (October 2017): 1243–49. http://dx.doi.org/10.1055/s-0043-120067.

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Zusammenfassung Hintergrund Myelin-Oligodendrozyten-Glykoprotein (MOG) ist an der Oberfläche der Myelinscheiden und der Oligodendrozyten im Zentralnervensystem lokalisiert. Im Kindes- und Erwachsenenalter zeigt sich eine Assoziation von MOG-AK im Serum mit rezidivierender und bilateraler Neuritis nervi optici (NNO), mit akuter disseminierter Enzephalitis (ADEM) und mit transverser Myelitis (TM). Die Kombination von NNO mit TM oder anderen entzündlichen Hirnläsionen ist typisch für eine Neuromyelitis-optica-Spektrum-Erkrankung (NMO-SD), die mit hochspezifischen pathogenen Aquaporin-4-IgG-Autoantikörpern (AQP4-AK) im Serum assoziiert ist. Kinder mit NMO-SD sind häufig seronegativ für AQP4-AK, aber seropositiv für MOG-AK. Krankheitsverlauf und Therapie der NNO bei Kindern mit NNO-positiven MOG-AK sind deshalb von besonderem Interesse. Patienten Die Krankheitsverläufe von 2 8-jährigen Jungen mit akuter NNO werden dargestellt (bilaterale NNO, AQP4-AK negativ, MOG-AK positiv). Patient 1 erlitt trotz immunsuppressiver Therapie mehrere Rezidive bei persistierenden MOG-AK mit zunehmender Optikusatrophie, erheblicher einseitiger Visusminderung und passagerer Hirnstammbeteiligung. Bei Patient 2 liegt ein bisher monophasischer Verlauf mit raschem Abfall der MOG-AK und nur geringer asymmetrischer Optikusatrophie vor. Diskussion MOG-AK sind im Kindesalter mit rezidivierender NNO und Hirnläsionen assoziiert, die typisch für eine ADEM oder eine NMO-SD sind. In der akuten Phase der klinischen Symptomatik werden hohe MOG-AK-Titer beobachtet. Rezidive der NNO führen zu einem zunehmenden Verlust der retinalen Nervenfaserschicht. Diagnostisch sind die Antikörperbestimmung (AQP4-AK, MOG-AK) sowie eine MRT-Bildgebung obligat. Als therapeutische Schlussfolgerung ergibt sich daraus die Notwendigkeit einer konsequenten Behandlung mit initial Kortikosteroiden und nachfolgender Immunsuppression (z. B. Azathioprin, Mycophenolat, bei refraktären Fällen auch Rituximab) sowie der Kontrolle der MOG-AK-Titer.

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Hain, B., M. Deschauer, and F. Hanisch. "Neue Erkenntnisse bei der seronegativen generalisierten Myasthenia gravis." Nervenheilkunde 23, no. 08 (2004): 465–70. http://dx.doi.org/10.1055/s-0038-1626409.

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ZusammenfassungDie generalisierte Myasthenia gravis (MG) ist eine Autoimmunerkrankung, die in 80-90% der Fälle durch pathogenetische Autoantikörper (AK) gegen nikotinerge Azetylcholinrezeptoren (AChR) gekennzeichnet ist. Bei einem Teil der Patienten mit AChR-AK-negativer generalisierter MG (so genannte seronegative MG) sind Autoantikörper gegen die muskelspezifische Rezeptor-Tyrosinkinase (MuSK) nachweisbar, die eine Rolle in der Anordnung der AChR während der Synapsenbildung spielt. Allerdings wird seit kurzem diskutiert, ob MuSK-AK lediglich ein Epiphänomen darstellen oder die Pathogenese hinreichend erklären können.Eine MuSK-AK-positive MG ist häufiger bei Frauen. Die bulbäre und Atemhilfsmuskulatur ist häufig betroffen. MuSK-AK-positive Patienten scheinen weniger gut auf eine medikamentöse immunsuppressive Therapie anzusprechen als AChR-AK-positive. Eine gute Wirksamkeit wird durch Plasmapherese erzielt. Pathologische Thymusbefunde sind bei MuSK-AK-positiven Fällen deutlich seltener als bei AChR-AK-positiven. Bislang ist noch ungeklärt, ob die Thymektomie den Krankheitsverlauf bei MuSK-AK-positiven Patienten beeinflusst.Weiterhin kann eine autoimmunvermittelte seronegative MG durch kongenitale Myasthenieformen mit späterem Manifestationsbeginn (Rapsyn-Mutationen, »slow-channel«-Syndrom durch AChR-Mutationen) vorgetäuscht werden.

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Calzavara-Pinton, Piergiacomo, Merete Hædersdal, Kirk Barber, Nicole Basset-Seguin, María Emilia Del Pino Flores, Peter Foley, Gaston Galimberti, et al. "Structured Expert Consensus on Actinic Keratosis: Treatment Algorithm Focusing on Daylight PDT." Journal of Cutaneous Medicine and Surgery 21, no. 1_suppl (April 13, 2017): 3S—16S. http://dx.doi.org/10.1177/1203475417702994.

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Background: A practical and up-to-date consensus among experts is paramount to further improve patient care in actinic keratosis (AK). Objectives: To develop a structured consensus statement on the diagnosis, classification, and practical management of AK based on up-to-date information. Methods: A systematic review of AK clinical guidelines was conducted. This informed the preparation of a 3-round Delphi procedure followed by a consensus meeting, which combined the opinions of 16 clinical experts from 13 countries, to construct a structured consensus statement and a treatment algorithm positioning daylight photodynamic therapy (dl-PDT) among other AK treatment options. Results: The systematic review found deficiencies in current guidelines with respect to new AK treatments such as ingenol mebutate and dl-PDT. The Delphi panel established consensus statements across definition, diagnosis, classification, and management of AK. While the diagnosis of AK essentially rests on the nature of lesions, treatment decisions are based on several clinical and nonclinical patient factors and diverse environmental attributes. Participants agreed on ranked treatment preferences for the management of AK and on classifying AK in 3 clinical situations: isolated AK lesions requiring lesion-directed treatment, multiple lesions within a small field, and multiple lesions within a large field, both requiring specific treatment approaches. Different AK treatment options were discussed for each clinical situation. Conclusions: The results provide practical recommendations for the treatment of AK, which are readily transferable to clinical practice, and incorporate the physician’s clinical judgement. The structured consensus statement positioned dl-PDT as a valuable option for patients with multiple AKs in small or large fields.

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Liang, Peng, Anton Jansen, and Paris Avgeriou. "Sharing architecture knowledge through models: quality and cost." Knowledge Engineering Review 24, no. 3 (September 2009): 225–44. http://dx.doi.org/10.1017/s0269888909990038.

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AbstractIn the field of software architecture, there has been a paradigm shift from describing structural information, such as components and connectors, to documenting architectural knowledge (AK), such as design decisions and rationale. To this end, a series of industrial and academic domain models have been proposed for defining the concepts and their relationships in the field of AK. To a large extent the merit of this new paradigm is to share and reuse AK across organizations, especially in geographically distributed settings. However, the employment of different AK domain models by different parties makes effective AK sharing challenging, as it needs to be mapped from one domain model to another. In this paper, we investigate two different approaches for sharing AK, based on either direct or indirect mapping between different AK domain models. We compare the cost and quality of these two approaches, with respect to the processing of large amounts of AK instances. To predict the quality and costs of this processing in advance, a prediction model is proposed and validated with a concrete AK sharing case. Based on the comparison results, stakeholders involved with AK sharing can select an appropriate approach by trading off quality and cost in their own context.

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Rivers, Jason K., Les Rosoph, Nathalie Provost, and Robert Bissonnette. "Open-Label Study to Assess the Safety and Efficacy of Imiquimod 5% Cream Applied Once Daily Three Times per Week in Cycles for Treatment of Actinic Keratoses on the Head." Journal of Cutaneous Medicine and Surgery 12, no. 3 (May 2008): 97–101. http://dx.doi.org/10.2310/7750.2008.07045.

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Background: Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy. Objective: To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application. Methods: Imiquimod 5% cream was administered three times per week for 4 weeks followed by 4 weeks of rest (cycle 1) to AK lesions on the head. If AK lesions remained visible at the end of cycle 1, a second treatment cycle was instituted. Results: Fifty percent (30 of 60) of patients experienced complete clearance of AK lesions, and 75% (30 of 40) of patients experienced partial clearance of AK lesions after imiquimod treatment at the end of cycle 2. Moreover, 77% of patients who achieved complete clearance had no visible AK lesions 12 weeks post-treatment. Imiquimod was well tolerated. Conclusion: Imiquimod cycle therapy may be a safe and effective treatment option for AK lesions.

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26

Matthews, Graham. "IPM at AK ALTIN." Outlooks on Pest Management 15, no. 5 (October 1, 2004): 238–39. http://dx.doi.org/10.1564/15oct15.

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27

Zernik, Clélia. "AK, une beauté empruntée." Vertigo 46, no. 2 (2013): 40. http://dx.doi.org/10.3917/ver.046.0040.

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28

Kaul, Subhash. "Obituary- “Prof. AK Meena”." Neurology India 68, no. 1 (2020): 242. http://dx.doi.org/10.4103/0028-3886.279706.

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29

Kahan, Alfred, and Ferdinand K. Euler. "AK‐cut quartz resonators." Journal of Applied Physics 57, no. 9 (May 1985): 4461–73. http://dx.doi.org/10.1063/1.334570.

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30

Scheiner, Joachim. "AK Verkehr page 2017." Journal of Transport Geography 63 (July 2017): 53–54. http://dx.doi.org/10.1016/j.jtrangeo.2017.06.006.

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Scheiner, Joachim. "AK Verkehr Page 2018." Journal of Transport Geography 72 (October 2018): 278–79. http://dx.doi.org/10.1016/j.jtrangeo.2018.10.001.

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32

HUGHES, KL. "The AK Sutherland Oration." Australian Veterinary Journal 72, no. 10 (October 1995): 361–63. http://dx.doi.org/10.1111/j.1751-0813.1995.tb06171.x.

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33

Pesch, H. J., and A. Schulz. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 15, no. 02 (2006): 154–57. http://dx.doi.org/10.1024/1019-1291.15.2.154.

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Pesch, H. J., and A. Schulz. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 15, no. 03 (2006): 226. http://dx.doi.org/10.1024/1019-1291.15.3.226.

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35

Brandt, J. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 15, no. 03 (2006): 227–28. http://dx.doi.org/10.1024/1019-1291.15.3.227.

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36

Pesch, H. J., and A. Schulz. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 15, no. 04 (2006): 278. http://dx.doi.org/10.1024/1019-1291.15.4.278.

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37

Pesch, H. J., and A. Schulz. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 01 (2007): 60–61. http://dx.doi.org/10.1024/1019-1291.16.1.60.

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38

Pesch, H. J., and A. Schulz. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 02 (2007): 159–60. http://dx.doi.org/10.1024/1019-1291.16.2.159.

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39

Bernstein, A., G. Berger, J. Brandt, R. Gildenhaar, H. Mayr, and D. Nöbel. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 02 (2007): 161. http://dx.doi.org/10.1024/1019-1291.16.2.161.

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40

Rolf, H. J. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 02 (2007): 162. http://dx.doi.org/10.1024/1019-1291.16.2.162.

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41

Lange, U. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 02 (2007): 163. http://dx.doi.org/10.1024/1019-1291.16.2.163.

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42

Pesch, H. J., and A. Schulz. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 04 (2007): 288. http://dx.doi.org/10.1024/1019-1291.16.4.288.

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43

Brandt, J. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 04 (2007): 289–91. http://dx.doi.org/10.1024/1019-1291.16.4.289.

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44

Simon, U., A. Berthold, S. Braschoß, and H. Schubert. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 04 (2007): 292–93. http://dx.doi.org/10.1024/1019-1291.16.4.292.

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45

Schwarz, M., G. Scheller, H. Köster, R. Wetzel, H. Schroeder-Boersch, and U. Schreiner. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 04 (2007): 294. http://dx.doi.org/10.1024/1019-1291.16.4.294.

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46

Gruber, R. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 04 (2007): 295. http://dx.doi.org/10.1024/1019-1291.16.4.295.

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47

Bernstein, A., G. Berger, J. Brandt, R. Gildenhaar, H. Mayr, and D. Nöbel. "Arbeitskreise (AK) der DGO." Osteologie/Osteology 16, no. 04 (2007): 296–97. http://dx.doi.org/10.1024/1019-1291.16.4.296.

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48

Lai, Paul B. S. "AK-47 and surgeons." Surgical Practice 18, no. 1 (February 2014): 1. http://dx.doi.org/10.1111/1744-1633.12050.

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49

Crott, Jimmy W. "Reply to AK Nersesyan." American Journal of Clinical Nutrition 84, no. 4 (October 1, 2006): 947–48. http://dx.doi.org/10.1093/ajcn/84.4.947.

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50

Eberhard, Sean, Kevin Ford, and Ben Green. "Permutations Fixing ak-set." International Mathematics Research Notices 2016, no. 21 (December 23, 2015): 6713–31. http://dx.doi.org/10.1093/imrn/rnv371.

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Journal articles on the topic 'AK'

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