To see the other types of publications on this topic, follow the link: AHC.
Journal articles on the topic 'AHC'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'AHC.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Weller, Claudia M., Wilhelmina G. Leen, Brian GR Neville, John S. Duncan, Boukje de Vries, Marije A. Geilenkirchen, Joost Haan, et al. "A novel SLC2A1 mutation linking hemiplegic migraine with alternating hemiplegia of childhood." Cephalalgia 35, no. 1 (May 13, 2014): 10–15. http://dx.doi.org/10.1177/0333102414532379.
Full textAbstract:
Background Hemiplegic migraine (HM) and alternating hemiplegia of childhood (AHC) are rare episodic neurological brain disorders with partial clinical and genetic overlap. Recently, ATP1A3 mutations were shown to account for the majority of AHC patients. In addition, a mutation in the SLC2A1 gene was reported in a patient with atypical AHC. We therefore investigated whether mutations in these genes may also be involved in HM. Furthermore, we studied the role of SLC2A1 mutations in a small set of AHC patients without ATP1A3 mutations. Methods We screened 42 HM patients (21 familial and 21 sporadic patients) for ATP1A3 and SLC2A1 mutations. In addition, four typical AHC patients and one atypical patient with overlapping symptoms of both disorders were screened for SLC2A1 mutations. Results A pathogenic de novo SLC2A1 mutation (p.Gly18Arg) was found in the atypical patient with overlapping symptoms of AHC and hemiplegic migraine. No mutations were found in the HM and the other AHC patients. Conclusion Screening for a mutation in the SLC2A1 gene should be considered in patients with a complex phenotype with overlapping symptoms of hemiplegic migraine and AHC.
2
de Vries, B., AH Stam, F. Beker, AMJM van den Maagdenberg, KRJ Vanmolkot, LAEM Laan, IB Ginjaar, et al. "CACNA1A Mutation Linking Hemiplegic Migraine and Alternating Hemiplegia of Childhood." Cephalalgia 28, no. 8 (August 2008): 887–91. http://dx.doi.org/10.1111/j.1468-2982.2008.01596.x.
Full textAbstract:
Familial hemiplegic migraine (FHM) and alternating hemiplegia of childhood (AHC) are severe neurological disorders that share clinical features. Therefore, FHM genes are candidates for AHC. We performed mutation analysis in the CACNA1A gene in a monozygotic twin pair with clinical features overlapping with both AHC and FHM and identified a novel de novo CACNA1A mutation. We provide the first evidence that a CACNA1A mutation can cause atypical AHC, indicating an overlap of molecular mechanisms causing AHC and FHM. These results also suggest that CACNA1A mutation scanning is indicated in patients with a severe neurological phenotype that includes paroxysmal (alternating) hemiplegia.
3
Zbikowski, Anke, A. Jelmer Brüggemann, Barbro Wijma, and Katarina Swahnberg. "Counteracting Abuse in Health Care: Evaluating a One-Year Drama Intervention with Staff in Sweden." International Journal of Environmental Research and Public Health 17, no. 16 (August 15, 2020): 5931. http://dx.doi.org/10.3390/ijerph17165931.
Full textAbstract:
In Northern European countries 13–28% of female patients seeking gynecological health care have reported abuse by health care staff (AHC). We conducted workshops with health care staff using the improvised role-play method Forum Play (FP), based on techniques developed by Boal. The study explores to what extent the intervention increased the staff’s awareness of AHC and their ability to take action against it. A total of 16 half-day FP workshops were conducted with staff from a Swedish women’s clinic over one year. Self-reported questionnaires were distributed to all staff before, during, and after the intervention. Primary outcome measures were the number of reported occasions of AHC and FP participants’ ability to act in AHC-situations. We found an increase in the participants’ self-reported ability to act in AHC-related situations. However, no change could be observed in the number of reported occasions of AHC between baseline and one year after the intervention. Health care staff’s participation in workshops using improvised role-play can increase staff’s perceived ability to take action in AHC situations. The voluntary nature of the intervention may have attracted those who were already aware of the topic, and likely explains the unchanged awareness of AHC.
4
AHN, SOO YEUN, and MAOYAN ZHU. "Lowermost Cambrian acritarchs from the Yanjiahe Formation, South China: implication for defining the base of the Cambrian in the Yangtze Platform." Geological Magazine 154, no. 6 (February 13, 2017): 1217–31. http://dx.doi.org/10.1017/s0016756816001369.
Full textAbstract:
AbstractTheAsteridium–Heliosphaeridium–Comasphaeridium(AHC) acritarch assemblage is composed of common organic-walled microfossils in the basal Cambrian chert–phosphorite units in South China, indicating that the AHC assemblage can be a useful biostratigraphic tool for the Ediacaran–Cambrian boundary successions in the Yangtze Platform. To test the validity of the AHC acritarch assemblage as a biostratigraphic tool, the stratigraphic range of the AHC acritarch assemblage was confirmed, and its spatial and temporal relationships to other bio- and chemostratigraphic tools were analysed in the Yanjiahe Formation, Yangtze Gorges area, South China. The result shows that the AHC assemblage temporally correlates to theAnabarites trisulcatus–Protohertzina anabaricaAssemblage Zone, and spatially correlates to the large negative carbon isotope anomaly of the lowermost Cambrian (BACE) in the Yanjiahe Formation. This implies that the radiation of phytoplankton occurred slightly before the radiation of the small shelly fossils, and the AHC acritarch assemblage can be another important chronological reference to the lowermost Cambrian successions in South China, and potentially to global correlations.
5
Durkovic, Jasmina, Tatjana Milenkovic, Nils Krone, Silvia Parajes, and Bojana Mandic. "Low estriol levels in the maternal marker screen as a predictor of X-linked adrenal hypoplasia congenita: Case report." Srpski arhiv za celokupno lekarstvo 142, no. 11-12 (2014): 728–31. http://dx.doi.org/10.2298/sarh1412728d.
Full textAbstract:
Introduction. X-linked adrenal hypoplasia congenita (AHC) is a rare cause of adrenocortical insufficiency. Early postnatal diagnosis may prevent severe hypoglycemia, Addisonian crises and death. Low maternal estriol (E3) levels in the second trimester of pregnancy could indicate the possibility that the fetus suffers from a disorder that causes adrenal insufficiency. Suspicion is based on the fact that E3 originates from dehydroepiandrosterone (DHEA) synthesized in the fetal adrenals. In case of adrenal insufficiency, the impaired production of fetal DHEA leads to a subsequent reduction of E3 concentrations in maternal serum. There are only a few reports of AHC suspected prenatally due to low maternal E3 levels. Case Outline. We describe two brothers with adrenal insufficiency due to AHC. The older brother was admitted to the hospital at the age of 33 days due to failure to thrive, vomiting, and dehydration. Genetic analysis revealed a hemizygous mutation in DAX-1 gene, thus confirming the diagnosis of ACH. The same mutation was detected in his mother. In the second pregnancy, E3 concentrations were determined from maternal serum. Estriol levels during the second trimester were extremely low suggesting the diagnosis of AHC. The diagnosis was confirmed during the neonatal period by genetic testing, and replacement therapy was started at the age of 10 days. This boy never experienced an adverse episode such as hypoglycemia or adrenal crises. Conclusion. Since determination of E3 is a simple, sensitive, noninvasive and cheap method, its use as an obligatory prenatal screening test should be accepted as a standard practice in Serbia.
6
Samanta, Debopam. "Ketamine Infusion for Super Refractory Status Epilepticus in Alternating Hemiplegia of Childhood." Neuropediatrics 51, no. 03 (February 3, 2020): 225–28. http://dx.doi.org/10.1055/s-0039-3402005.
Full textAbstract:
AbstractAlternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder and characterized by infantile onset hemiplegia involving either side of the body and other paroxysmal spells, including epilepsy. The N-methyl-D-aspartate (NMDA) receptor noncompetitive antagonist ketamine has been proved to be effective terminating status epilepticus (SE) in animal models and human case studies. Less than 50 cases, those use ketamine, have been reported in the management of pediatric SE, but its effectiveness is unknown in patients with AHC. The author reported two patients with molecularly confirmed AHC who presented with super refractory status epilepticus. These two patients failed multiple antiepileptic drugs, including midazolam infusion and propofol but responded promptly to ketamine infusion. This is the first description of the effectiveness of ketamine as an effective third-line agent for super refractory SE associated with AHC. Increased glutamate-mediated neurotoxicity can be present in AHC, not only due to overexpression of glutamate receptors during status epilepticus but also due to unique characteristics of AHC-preferential inactivity of GABAergic interneuron and impaired action of glutamate transporters (EAAT-1). Moreover, as neuroregression is possible after SE in AHC, earlier termination of SE by using ketamine can be an effective option in this population. Further prospective, controlled studies are needed to confirm the finding of this study.
7
Wetzker, Wibke, Janine Walter, Karin Bunte-Schönberger, Frank Schwab, Michael Behnke, Petra Gastmeier, and Christiane Reichardt. "Hand Rub Consumption Has Almost Doubled in 132 German Hospitals Over 9 Years." Infection Control & Hospital Epidemiology 38, no. 7 (May 31, 2017): 870–72. http://dx.doi.org/10.1017/ice.2017.71.
Full textAbstract:
Annual surveillance data (2007–2015), collected continuously in 132 German hospitals, was evaluated for development of alcohol-based hand-rub consumption (AHC) as a surrogate parameter for hand hygiene adherence. Overall, the median increase in AHC was 94%. The increases over 9 years were significant in all units and quartiles of AHC at baseline.Infect Control Hosp Epidemiol 2017;38:870–872
8
Imoto, Susumu, Soo Ryang Kim, Keisuke Amano, Etsuko Iio, Seitetsu Yoon, Shigeya Hirohata, Yoshihiko Yano, et al. "Serum IFN-λ3 Levels Correlate with Serum Hepatitis C Virus RNA Levels in Symptomatic Patients with Acute Hepatitis C." Digestive Diseases 35, no. 6 (2017): 531–40. http://dx.doi.org/10.1159/000480143.
Full textAbstract:
Background: Recent genome-wide association studies demonstrated that 2 single nucleotide polymorphisms (SNPs), upstream of the interferon-λ (IFNL) 3 gene, are associated with the spontaneous clearance of hepatitis C virus (HCV) in symptomatic patients with acute hepatitis C (AHC). Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to spontaneously clear HCV in patients with AHC, the detailed mechanisms of their roles remain largely unknown. Aim: This study is aimed at clarifying the factors affecting IFNL3 production and assessing the roles of IFNL3 in AHC. Materials and Methods: A total of 21 AHC patients who visited the hospital within 10 days after symptom onset were assessed. As controls, 23 healthy volunteers (HVs) were examined. Serum IFNL3 levels were quantified using an in-house, IFNL3-specific chemiluminescence enzyme immunoassay (CLEIA) kit. Serum IFNL1, IFN-α, IFN-β, and IFN-γ induced protein-10 (IP-10) levels were assayed using commercial enzyme-linked immunosorbent assay (ELISA) kits. Results: At baseline, serum IFNL3 levels were higher in AHC patients than in HVs (p < 0.0001). The higher levels in AHC patients did not differ between patients with the rs8099917 TT genotype and those with the non-TT (TG/GG) genotype (p = 0.546). Serial measurement of serum IFNL3 levels did not predict the outcome of conventional AHC. However, serum IFNL3 levels at baseline correlated positively with the HCV RNA levels (p = 0.005). Following HCV eradication, serum IFNL3 levels reduced to within the range obtained for HVs. Baseline serum IFNL1 levels did not differ significantly between AHC patients and HVs (p = 0.284). Serum levels of IFNL1 and IFNL3 at baseline also showed no correlative power (p = 0.288). Serum IFN-α and IFN-β were detected together with remarkably high serum IFNL3 levels in only one patient who progressed to acute liver failure (ALF). Conclusion: These findings indicate that serum IFNL3 levels at baseline are higher in AHC patients regardless of the rs8099917 polymorphism, and primary HCV infection triggers the production of IFNL3. As a first line of defense in the innate immune system against invading HCV, increased IFNL3 levels play an important role, but serum IFNL3 levels are not the principal determinant of the clinical course of conventional AHC.
9
Peter, Michael, Matthias Viemann, Carl-Joachim Partsch, and Wolfgang G. Sippell. "Congenital Adrenal Hypoplasia: Clinical Spectrum, Experience with Hormonal Diagnosis, and Report on New Point Mutations of the DAX-1 Gene." Journal of Clinical Endocrinology & Metabolism 83, no. 8 (August 1, 1998): 2666–74. http://dx.doi.org/10.1210/jcem.83.8.5027.
Full textAbstract:
abstract X-linked congenital adrenal hypoplasia (AHC) is a rare developmental disorder of the human adrenal cortex and is caused by deletion or mutation of the DAX-1 gene, a recently discovered member of the nuclear hormone receptor superfamily. Hypogonadotropic hypogonadism is frequently associated with AHC. AHC occurs as part of a contiguous gene syndrome together with glycerol kinase deficiency (GKD) and Duchenne’s muscular dystrophy. The present series, collected over the past 2 decades, includes 18 AHC boys from 16 families: 4 with AHC, GKD, and Duchenne’s muscular dystrophy; 2 with AHC and GKD; and 12 with AHC (5 young adults with hypogonadotropic hypogonadism). Most of the boys presented with salt wasting and hyperpigmentation during the neonatal period. Plasma steroid determinations performed in the first weeks of life often showed confusing results, probably caused by steroids produced in the neonates’ persisting fetocortex. Aldosterone deficiency usually preceded cortisol deficiency, which explains why the patients more often presented with salt-wasting rather than with hypoglycemic symptoms. An ACTH test was often necessary to detect cortisol deficiency in the very young infants. In some patients, serial testing was necessary to establish the correct diagnosis. In 4 boys studied during the first 3 months after birth, we found pubertal LH, FSH, and testosterone plasma levels indicating postnatal transient activation of the hypothalamic-pituitary-gonadal axis as in normal boys. Previous studies have shown that the DAX-1 gene is deleted in the AHC patients with a contiguous gene syndrome and is mutated in nondeletion patients. Most of the point mutations identified in AHC patients were frameshift mutations and stop mutations. In the 15 patients available for molecular analysis of the DAX-1 gene, there were large deletions in 6 patients and point mutations in another 7 patients. All of the point mutations identified in the present study resulted in a nonfunctional truncated DAX-1 protein. Two brothers with primary adrenal insufficiency and a medical history that strongly suggested AHC had no mutation in the DAX-1 gene. Thus, additional, as yet unknown genes must play a part in normal adrenal cortical development.
10
Behnke, Michael, Petra Gastmeier, Christine Geffers, Nadine Mönch, and Christiane Reichardt. "Establishment of a National Surveillance System for Alcohol-Based Hand Rub Consumption and Change in Consumption over 4 Years." Infection Control & Hospital Epidemiology 33, no. 6 (June 2012): 618–20. http://dx.doi.org/10.1086/665729.
Full textAbstract:
Germany established a national surveillance system for alcohol-based hand rub consumption (AHC) in 2008. In 2010, the median AHC was 83 mL/patient-day in 543 intensive care units (ICUs) and 18 mL/patient-day in 4,638 non-ICUs. There was a median increase in AHC of 35.9% (P < .01) in 159 hospitals that participated in the surveillance system for 4 years.
11
CHEN, S. L., R. C. LIU, F. M. CHEN, X. X. ZHANG, J. ZHAO, and T. M. CHEN. "Dynamic modelling of strategies for the control of acute haemorrhagic conjunctivitis outbreaks in schools in Changsha, China (2004–2015)." Epidemiology and Infection 145, no. 2 (October 19, 2016): 368–78. http://dx.doi.org/10.1017/s0950268816002338.
Full textAbstract:
SUMMARYOutbreaks of acute haemorrhagic conjunctivitis (AHC) – a rapidly progressing and highly contagious infection – often occur in schools during summer and autumn. We used dynamic modelling to evaluate the efficacy of interventions to control AHC outbreaks in schools. A susceptible-infected-recovered (SIR) model was built to simulate AHC outbreaks in Chinese schools, with isolation or school closure added into the model. We used outbreak data from the period 2004–2015 in our models to estimate the effective reproduction number and assess the efficacy of interventions. The median effective reproduction number (uncontrolled) of AHC outbreaks was 7·00 (range 1·77–25·87). The median effective reproduction number (controlled) of AHC outbreaks was 0·16 (range 0·00–2·28). Intervention efficacy is affected by the timing of isolation; earlier isolation is associated with a lower morbidity peak and smaller total attack rate (TAR). School closures were not effective; TARs were almost 100% and did not change even when different school closure durations were adopted. Isolation and school closure as a combined intervention strategy was used to simulate outbreak control, but the efficacy was the same as isolation alone. An isolation programme could be an effective primary intervention during AHC outbreaks in schools. However, school closure is not recommended.
12
Ivchenko, V. O., N. C. Wells, D. L. Aleynik, and A. G. P. Shaw. "Variability of heat and salinity content in the North Atlantic in the last decade." Ocean Science Discussions 6, no. 3 (September 4, 2009): 1971–2003. http://dx.doi.org/10.5194/osd-6-1971-2009.
Full textAbstract:
Abstract. The analysis of the heat and salinity contents have been made for the Northern Atlantic for the decade between January 1999 and December 2008. This analysis is based on the Argo profiling data for the upper 2000 m. Basin-averaged values of anomaly of heat (AHC) and anomaly of salinity content (ASC) are robust and stable. The AHC and ASC demonstrate positive trends in the last decade in the upper 2000 m of the North Atlantic. The linear trend of AHC and ASC are (126.43±18.52)×1020 J, and (47.07±6.90)×1013 kg, respectively. Both trends are significant at 95% level of significance. The main contribution to the positive trend of AHC/ASC comes from the northern parts of the basin.
13
Choi, Su Min, Van Cong Pham, Sangkyu Lee, and Jeong Ah Kim. "Metabolism of Diterpenoids Derived from the Bark of Cinnamomum cassia in Human Liver Microsomes." Pharmaceutics 13, no. 8 (August 23, 2021): 1316. http://dx.doi.org/10.3390/pharmaceutics13081316.
Full textAbstract:
Cinnamomum cassia L. is used as a spice and flavoring agent as well as a traditional medicine worldwide. Diterpenoids, a class of compounds present in C. cassia, have various pharmacological effects, such as anti-inflammatory, antitumor, and antibacterial activities; however, there are insufficient studies on the metabolism of diterpenoids. In this study, the metabolism of seven diterpenoids, namely, anhydrocinnzeylanol, anhydrocinnzeylanine (AHC), cinncassiol A, cinncassiol B, cinnzeylanol, cinnzeylanone, and cinnzeylanine, obtained from the bark of C. cassia was studied in human liver microsomes (HLMs). All studied diterpenoids, except for AHC, exhibited strong metabolic stability; however, AHC was rapidly metabolized to 3% in HLMs in the presence of β-NADPH. Using a high-resolution quadrupole-orbitrap mass spectrometer, 20 metabolites were identified as dehydrogenated metabolites (M1–M3), dehydrogenated and oxidated metabolites (M4–M10), mono-oxidated metabolites (M11–M13), or dioxidated metabolites (M14–M20). In addition, CYP isoforms involved in AHC metabolism were determined by profiling metabolites produced after incubation in 11 recombinant cDNA-expressed CYP isoforms. Thus, the diterpenoid compound AHC was identified in a metabolic pathway involving CYP3A4 in HLMs.
14
Baggen, Jim, Daniel L. Hurdiss, Georg Zocher, Nitesh Mistry, Richard W. Roberts, Jasper J. Slager, Hongbo Guo, et al. "Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus." Proceedings of the National Academy of Sciences 115, no. 2 (December 28, 2017): 397–402. http://dx.doi.org/10.1073/pnas.1713284115.
Full textAbstract:
Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases in the last decades. Coxsackievirus A24 (CV-A24) was not originally associated with human disease, but in 1970 a pathogenic “variant” (CV-A24v) emerged, which is now the main cause of AHC. Initially, this variant circulated only in Southeast Asia, but it later spread worldwide, accounting for numerous AHC outbreaks and two pandemics. While both CV-A24 variant and nonvariant strains still circulate in humans, only variant strains cause AHC for reasons that are yet unknown. Since receptors are important determinants of viral tropism, we set out to map the CV-A24 receptor repertoire and establish whether changes in receptor preference have led to the increased pathogenicity and rapid spread of CV-A24v. Here, we identify ICAM-1 as an essential receptor for both AHC-causing and non-AHC strains. We provide a high-resolution cryo-EM structure of a virus–ICAM-1 complex, which revealed critical ICAM-1–binding residues. These data could help identify a possible conserved mode of receptor engagement among ICAM-1–binding enteroviruses and rhinoviruses. Moreover, we identify a single capsid substitution that has been adopted by all pandemic CV-A24v strains and we reveal that this adaptation enhances the capacity of CV-A24v to bind sialic acid. Our data elucidate the CV-A24v receptor repertoire and point to a role of enhanced receptor engagement in the adaptation to the eye, possibly enabling pandemic spread.
15
Fatema, Kanij, Md Mizanur Rahman, Shaheen Akter, Suraiya Begum, and Md Tanvir Islam. "Alternating Hemiplegia of Childhood: Report of Two Cases." Journal of Enam Medical College 8, no. 1 (February 7, 2018): 46–49. http://dx.doi.org/10.3329/jemc.v8i1.35436.
Full textAbstract:
Alternating hemiplegia of childhood (AHC) is a rare disorder which presents before 18 months of age characterized by repeated attacks of hemiplegia involving either side of the body, paroxysmal disturbances,developmental delay and learning disability. The cause of AHC remains largely unknown and treatment evidence is less available. AHC is unreported in Bangladeshi literature. We report two cases of AHC. Our first case is a 16-month-old girl who presented with hemiplegia in alternate side for four episodes. She also had abnormal body movement and irritability during awakening. Every episode subsided spontaneously after 2 to 5 days. All investigations were normal except iron deficiency anemia. She was treated with flunarizine. Our second case, a 7 year and 10 month-old boy presented with recurrent alternate hemiplegia since 3½ years of age with epilepsy. His attacks were precipitated in high temperature. His EEG was abnormal. He was treated with multiple antiepileptic drugs and flunarizine. These are first two cases reported from Bangladesh. AHC remains undiagnosed in many cases. So a detailed history and diagnostic evaluation is very important for early counseling and treatment.J Enam Med Col 2018; 8(1): 46-49
16
Haan, J., EE Kors, GM Terwindt, FLMG Vermeulen, MN Vergouwe, AMJM van den Maagdenberg, DS Gill, et al. "Alternating Hemiplegia of Childhood: No Mutations in the Familial Hemiplegic Migraine CACNA1A Gene." Cephalalgia 20, no. 8 (October 2000): 696–700. http://dx.doi.org/10.1046/j.0333-1024.2000.00095.x.
Full textAbstract:
Introduction Alternating hemiplegia of childhood (AHC) is a rare disorder mainly characterized by attacks of hemiplegia and mental retardation. It has been often associated with migraine. The CACNA1A gene on chromosome 19 is involved in familial hemiplegic migraine and other episodic cerebral disorders, but also with progressive neuronal damage. Methods We performed mutation analysis in this gene in four AHC patients, using single strand conformation polymorphism analysis. Results We found nine polymorphisms, but no mutations in any of the 47 exons. Conclusions Other cerebral ion channel genes remain candidate genes for AHC.
17
Xu, X., H. He, and D. Hu. "Efficient Reinforcement Learning Using Recursive Least-Squares Methods." Journal of Artificial Intelligence Research 16 (April 1, 2002): 259–92. http://dx.doi.org/10.1613/jair.946.
Full textAbstract:
The recursive least-squares (RLS) algorithm is one of the most well-known algorithms used in adaptive filtering, system identification and adaptive control. Its popularity is mainly due to its fast convergence speed, which is considered to be optimal in practice. In this paper, RLS methods are used to solve reinforcement learning problems, where two new reinforcement learning algorithms using linear value function approximators are proposed and analyzed. The two algorithms are called RLS-TD(lambda) and Fast-AHC (Fast Adaptive Heuristic Critic), respectively. RLS-TD(lambda) can be viewed as the extension of RLS-TD(0) from lambda=0 to general lambda within interval [0,1], so it is a multi-step temporal-difference (TD) learning algorithm using RLS methods. The convergence with probability one and the limit of convergence of RLS-TD(lambda) are proved for ergodic Markov chains. Compared to the existing LS-TD(lambda) algorithm, RLS-TD(lambda) has advantages in computation and is more suitable for online learning. The effectiveness of RLS-TD(lambda) is analyzed and verified by learning prediction experiments of Markov chains with a wide range of parameter settings. The Fast-AHC algorithm is derived by applying the proposed RLS-TD(lambda) algorithm in the critic network of the adaptive heuristic critic method. Unlike conventional AHC algorithm, Fast-AHC makes use of RLS methods to improve the learning-prediction efficiency in the critic. Learning control experiments of the cart-pole balancing and the acrobot swing-up problems are conducted to compare the data efficiency of Fast-AHC with conventional AHC. From the experimental results, it is shown that the data efficiency of learning control can also be improved by using RLS methods in the learning-prediction process of the critic. The performance of Fast-AHC is also compared with that of the AHC method using LS-TD(lambda). Furthermore, it is demonstrated in the experiments that different initial values of the variance matrix in RLS-TD(lambda) are required to get better performance not only in learning prediction but also in learning control. The experimental results are analyzed based on the existing theoretical work on the transient phase of forgetting factor RLS methods.
18
Zainol, M. K., F. W. Abdul Sukor, A. Fisal, T. C. Tuan Zainazor, M. R. Abdul Wahab, and A. I. Zamri. "Optimization of enzymatic protein hydrolysis conditions of Asiatic hard clam (Meretrix meretrix)." Food Research 5, no. 4 (July 25, 2021): 153–62. http://dx.doi.org/10.26656/fr.2017.5(4).701.
Full textAbstract:
This study was aimed to optimise the Alcalase® enzymatic hydrolysis extraction of Asiatic hard clam (AHC) (Meretrix meretrix) protein hydrolysate in terms of hydrolysis time, hydrolysis temperature, hydrolysis pH, and concentration of enzyme. Protein hydrolysate produced from AHC (M. meretrix) meat was used to determine the optimum hydrolysis conditions. Hydrolysis of AHC meat was optimised using the Central Composite Design Response Surface Methodology (RSM) (CCD). The relationship between four parameters such as temperature (45 – 65°C), enzyme to substrate concentration (1 – 2%), hydrolysis time (60 – 180 mins), and pH (7.5 – 9.5) to the degree of hydrolysis was investigated. The optimum conditions for enzymatic hydrolysis of AHC meat to achieve the maximum degree of hydrolysis (DH) were observed at 65°C, enzyme to substrate concentration of 1%, hydrolysis time of 60 mins, and pH 7.5. The enzymatic protein hydrolysis of AHC meat was predicted using a two factors interaction (2FI) model. Under these optimum conditions, DH's predicted value was 97.41%, which was close to the experimental value (97.89%). The freeze-dried protein hydrolysate powder was characterized concerning the proximate composition. Proximate analysis revealed that the AHC meat contains 7.92±1.76% of moisture, 2.23±0.89% of crude fat, 1.98±0.82 of ash, and 10.53±0.04% of crude protein. While the Asiatic hard clam protein hydrolysate (AHCPH) composed 9.12±0.02% of moisture, 0.80±0.29% of crude fat, and 27.76±0.10% of ash. The protein hydrolysate produced also contained high protein content (50.09±0.88%) and may serve as a good protein source.
19
Ryu, Mina, Chung Ki Sung, Young Jun Im, and ChangJu Chun. "Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract." Molecules 25, no. 5 (February 27, 2020): 1073. http://dx.doi.org/10.3390/molecules25051073.
Full textAbstract:
JNK and p38 are important mitogen-activated protein kinases (MAPKs) that respond to stress stimuli. The stress-activated MAPKs associated with apoptotic cell death play vital roles in mammalian cells. Alnus hirsuta, which contains abundant diarylheptanoids derivatives, is a valuable medicinal plant. The CHCl3 extract (AHC) containing platyphyllenone (1) and platyphyllone (3) as main compounds showed in vitro anticancer effects. We report the biological activities of A. hirsuta extract associated with the regulation of apoptosis and JNK and p38 in MCF-7 breast cancer cells. Levels of phospho-JNK and phospho-p38 by AHC treatment were evaluated by enzyme-linked immunosorbent assay (ELISA). ROS production, apoptotic effect, and DNA contents of the cells were measured by flow cytometry. The two diarylheptanoids 1 and 3 and the AHC extract exhibited cytotoxic effects on MCF-7 cells in MTT assay, with IC50 values of 18.1, 46.9, 260.0 μg/mL, respectively. AHC induced ROS generation and elevated the endogenous levels of phospho-JNK and phospho-p38. AHC resulted in apoptosis and cell cycle arrest. We suggest that the antitumor effect of A. hirsuta extract is achieved by apoptosis promotion and cell cycle arrest mediated by the activation of JNK and p38 signaling pathway via ROS generation.
20
Keating, Joseph C. "2006 AHC Conference on Chiropractic History." Journal of Chiropractic Education 21, no. 1 (April 1, 2007): 32–33. http://dx.doi.org/10.7899/1042-5055-21.1.32.
Full text
21
Frenken, Ansgar. "Bibliographie zur Konziliengeschichte (AHC 2011/1)." Annuarium Historiae Conciliorum 43, no. 1 (June 20, 2011): 235–40. http://dx.doi.org/10.30965/25890433-04301011.
Full text
22
Frenken, Ansgar. "Bibliographie zur Konziliengeschichte (AHC 2011/2)." Annuarium Historiae Conciliorum 43, no. 2 (June 20, 2011): 473–80. http://dx.doi.org/10.30965/25890433-04302011.
Full text
23
Crouse, B. J., C. Mueller, and D. L. Uden. "AHC–community partnerships for interdisciplinary education." Academic Medicine 73, no. 9 (September 1998): 920–1. http://dx.doi.org/10.1097/00001888-199809000-00003.
Full text
24
Boex, James R., and Rebecca C. Henry. "Principles to Guide AHC—Community Partnerships." Academic Medicine 76, no. 2 (February 2001): 151–52. http://dx.doi.org/10.1097/00001888-200102000-00011.
Full text
25
Chanda, SC, Md A. Razzak, Md E. Haque, and AKM Golam Sarwar. "Multivariate analysis of morphological descriptors for identification of Sesbania Scop. accessions." Bangladesh Journal of Scientific and Industrial Research 55, no. 3 (September 24, 2020): 215–20. http://dx.doi.org/10.3329/bjsir.v55i3.49395.
Full textAbstract:
Based on the 36 quantitative morphological descriptors, agglomerative hierarchical clustering (AHC) and principal component analyses (PCA) were conducted to identify 106 diverse Sesbania accessions. The AHC analysis identified three major clusters with 11 sub-clusters. In PCA, the first and second PCs explain 72.48% and 12.72% of total variations with high Eigen value 9.1 and 1.7, respectively. Sesbania accessions occupied four distinct positions in the PCA graph. Based on multivariate analyses and qualitative descriptors, Sesbania accessions have been identified as S. bispinosa (90 accessions), S. cannabina (9 accessions), S. sesban (6 accessions) and the known S. rostrata. The AHC dendrogram has detected the close similarities between S. rostrata and S. cannabina. However, the PCA has emerged to be better than the AHC as a species identification tool. Among these four species, the highest discriminating distance (23.69%) was observed between S. sesban and S. bispinosa, and the lowest (10.52%) was in S. bispinosa and S. cannabina.
Bangladesh J. Sci. Ind. Res.55(3), 215-220, 2020
26
Balestrini, Simona, Mohamad A. Mikati, Reyes Álvarez-García-Rovés, Michael Carboni, Arsen S. Hunanyan, Bassil Kherallah, Melissa McLean, et al. "Cardiac phenotype in ATP1A3-related syndromes." Neurology 95, no. 21 (September 10, 2020): e2866-e2879. http://dx.doi.org/10.1212/wnl.0000000000010794.
Full textAbstract:
ObjectiveTo define the risks and consequences of cardiac abnormalities in ATP1A3-related syndromes.MethodsPatients meeting clinical diagnostic criteria for rapid-onset dystonia-parkinsonism (RDP), alternating hemiplegia of childhood (AHC), and cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) with ATP1A3 genetic analysis and at least 1 cardiac assessment were included. We evaluated the cardiac phenotype in an Atp1a3 knock-in mouse (Mashl+/−) to determine the sequence of events in seizure-related cardiac death.ResultsNinety-eight patients with AHC, 9 with RDP, and 3 with CAPOS (63 female, mean age 17 years) were included. Resting ECG abnormalities were found in 52 of 87 (60%) with AHC, 2 of 3 (67%) with CAPOS, and 6 of 9 (67%) with RDP. Serial ECGs showed dynamic changes in 10 of 18 patients with AHC. The first Holter ECG was abnormal in 24 of 65 (37%) cases with AHC and RDP with either repolarization or conduction abnormalities. Echocardiography was normal. Cardiac intervention was required in 3 of 98 (≈3%) patients with AHC. In the mouse model, resting ECGs showed intracardiac conduction delay; during induced seizures, heart block or complete sinus arrest led to death.ConclusionsWe found increased prevalence of ECG dynamic abnormalities in all ATP1A3-related syndromes, with a risk of life-threatening cardiac rhythm abnormalities equivalent to that in established cardiac channelopathies (≈3%). Sudden cardiac death due to conduction abnormality emerged as a seizure-related outcome in murine Atp1a3-related disease. ATP1A3-related syndromes are cardiac diseases and neurologic diseases. We provide guidance to identify patients potentially at higher risk of sudden cardiac death who may benefit from insertion of a pacemaker or implantable cardioverter-defibrillator.
27
Silva-Espinoza, Brenda A., Luis A. Ortega-Ramírez, Gustavo A. González-Aguilar, Isela Olivas, and Jesús F. Ayala-Zavala. "PROTECCIÓN ANTIFÚNGICA Y ENRIQUECIMIENTO ANTIOXIDANTE DE FRESA CON ACEITE ESENCIAL DE HOJA DE CANELA." Revista Fitotecnia Mexicana 36, no. 3 (September 11, 2013): 217. http://dx.doi.org/10.35196/rfm.2013.3.217.
Full textAbstract:
Los frutos de fresa (Fragaria ananassa Duch.) son apreciados por su contenido de compuestos antioxidantes, pero son susceptibles al ataque por hongos. Un extracto natural que ha mostrado poseer capacidad antifúngica y antioxidante es el aceite de hoja de canela (Cinnamomum zeylanicum) (AHC), el cual podría contemplarse como una opción para disminuir el crecimiento de hongos y aumentar el nivel de antioxidantes en fresas. El objetivo de este trabajo fue evaluar el efecto del tratamiento con AHC para el control de hongos y sobre la capacidad antioxidante del fruto. Se midió el desarrollo de hongos, contenido de fenoles, flavonoides totales, capacidad antioxidante y nivel de agrado (olor y sabor) de frutos de fresa tratadas con emulsiones de AHC (Testigo, 0.0005, 0.0025 y 0.005 g mL-1) y almacenadas durante 9 d a 10 ºC. Se observó una inhibición significativa (P ≤ 0.05) del ataque por hongos por efecto de los tratamientos con AHC, y la concentración de 0.005 g mL-1 fue la más efectiva; además incrementó los contenidos de fenoles (78 %) y de flavonoides totales (35 %), y con ello elevó la capacidad antioxidante de los frutos, medida con las técnicas de DPPH• (52 %), TEAC (32 %) y ORAC (25 %), en comparación con los frutos testigo. El olor y sabor de las fresas testigo y las tratadas con 0.0005 g mL-1 de AHC agradaron moderadamente; las fresas tratadas con 0.0025 g mL-1 ni agradaron ni desagradaron, mientras que las tratadas con 0.005 g mL-1 desagradaron moderadamente. Por tanto, la aplicación del AHC parece ser un tratamiento viable para reducir el daño por hongos e incrementar las propiedades antioxidantes de frutos de fresa, aunque afecta moderadamente el nivel de agrado.
28
ZHANG, L., N. ZHAO, J. SHA, C. WANG, X. JIN, S. AMER, and S. LIU. "Virology and epidemiology analyses of global adenovirus-associated conjunctivitis outbreaks, 1953–2013." Epidemiology and Infection 144, no. 8 (January 6, 2016): 1661–72. http://dx.doi.org/10.1017/s0950268815003246.
Full textAbstract:
SUMMARYThis study aimed to compare the virology and epidemiology of epidemic keratoconjunctivitis (EKC), pharyngoconjunctival fever (PCF) and acute haemorrhagic conjunctivitis (AHC) outbreaks worldwide caused by the human adenovirus (HAdV) from 1953 to 2013. Eighty-three hexon sequences from 76 conjunctivitis outbreaks were analysed and subtyped using Mega 5.05, Clustal X and SimPlot software. Epidemiology was performed for the area, age and seasonal distribution. A phylogenetic analysis indicated that all the isolates could be divided into three subgenetic lineages, without a common ancestor. The major causes of the outbreaks were Ad8, Ad7 and Ad2 co-infection with enterovirus 70 (EV70) in EKC, PCF and AHC, respectively. The epidemiological findings suggested that EKC and AHC were circulating predominantly in Asia during the early winter and spring, whereas PCF was circulating mainly in China, Australia and the United States during the summer. This study suggests that EKC, AHC and PCF outbreaks have different circulating patterns throughout the world and are caused by different adenovirus serotypes. A global surveillance system should be established to monitor conjunctivitis outbreaks in the future.
29
Holze, Niklas, Andreas Baalen, Ulrich Stephani, Ingo Helbig, and Hiltrud Muhle. "Variants in the ATP1A3 Gene Mutations within Severe Apnea Starting in Early Infancy: An Observational Study of Two Cases with a Possible Relation to Epileptic Activity." Neuropediatrics 49, no. 05 (May 25, 2018): 342–46. http://dx.doi.org/10.1055/s-0038-1653978.
Full textAbstract:
AbstractMutations in the ATP1A3 gene are known to cause alternating hemiplegia of childhood (AHC) and rapid-onset dystonia parkinsonism (RDP). Both conditions are childhood-onset neurological disorders with distinct symptoms and different times of onset. ATP1A3 has also been associated with CAPOS syndrome (cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss). Within the various ATP1A3-related neurological syndromes, a specific genotype–phenotype correlation is starting to emerge. Several mutations such as the relatively common p.E815K pathogenic variant have been shown to strongly correlate with AHC, while others may cause both AHC and RDP. A significant subset of patients with AHC and RDP are reported to have epileptic seizures. Even though detailed clinical descriptions of seizures in childhood are rare, seizures involving apneic events seem to be frequent in ATP1A3-related neurological disorders. Here, we describe two children with unexplained severe apnea beginning around the first year of life and pathogenic variants in ATP1A3. We hypothesize that the symptoms are early-onset autonomic seizures related to the underlying pathogenic ATP1A3 variants.
30
Gu, Tiantian, Dezhi Li, and Lingzhi Li. "The Elderly’s Demand for Community-Based Care Services and Its Determinants: A Comparison of the Elderly in the Affordable Housing Community and Commercial Housing Community of China." Journal of Healthcare Engineering 2020 (October 21, 2020): 1–13. http://dx.doi.org/10.1155/2020/1840543.
Full textAbstract:
With the rapid aging of the world population, great pressure has been placed on the provision of community-based care in China. This paper aimed to compare the demand and its determinants for various community-based care services among the elderly in the affordable housing community (AHC) and commercial housing community (CHC) of China. Two community-based surveys were conducted separately in the AHC and CHC of Nanjing City, China. In total, 408 valid questionnaires were returned from the Daishan AHC while 8422 valid questionnaires were received from the CHCs. The chi square test indicated that the respondents in the AHC had significantly higher demands for five types of services (the meal-aid service, the cleaning-aid service, the bath-aid service, the rehabilitation therapy service, and the first-aid service) than those in the CHCs of Nanjing. Further, the Cochran–Mantel–Haenszel test showed that factors influencing the elderly’s demands for these services varied across communities. Several policy implications could be obtained to improve the efficiency of community-based care provision.
31
Тимошенко, О. П., and О. С. Снопенко. "Зміна площі волосяної кутикули у свійських котів за нефропатії та поліорганної патології." Вісник Полтавської державної аграрної академії, no. 2 (June 27, 2018): 125–31. http://dx.doi.org/10.31210/visnyk2018.02.20.
Full textAbstract:
Встановлено, що за різних варіантів нефропатії та за розвитку печінково-ниркового і нирково-печінкового синдромів у свійських котів у печінці й нирках відбуваються значні структурні зміни, яким відповідають порушення метаболічних процесів, визначених за результатами клініко-мікроскопічних та біохімічних досліджень крові, а також у змінах площі волосяної кутикули (ПВК) шерстного покрову свійських котів. Методику визначення ПВК можна використовувати в диференційній діагностиці різних варіантів патології нирок і печінки в комплексі з клінічними, інструментальними та лабораторними дослідженнями, а також за диспансерного обстеження тварин даного виду. У статті наведено приклади різних варіантів патології із визначенням ПВК.
89 males and females of domestic cats, aged 2.5–10.0 years, were examined. It was established that under different variants of nephropathy and for the development of hepatic and renal hepatic syndromes in domestic cats in the liver and kidneys there are significant structural changes that is reflected in the disturbances of metabolic processes determined by the results of clinical and microscopic and biochemical studies of blood serum, as well as changes in the area of hair cuticle (AHC) of the wool cover of cats. The study of the cuticle was carried out using negative impressions on a nitrocellulose lacquer, which was applied to the slide glass. Hair was removed from him after lacquering. The resulting imprint was analyzed under Carl Zeiss Jena microscope (Ч 400) and set the AHC in the root zone and in the thickest part of the rod, expressing the result in nm2. In 40 % of clinically healthy cats, the size of the hair cuticle (AHC) is 8–9x104 nm2; in 60 % of animals – 10–17x104 nm2. Such a significant spread of indicators is due to different age of animals and the influence of the rock factor. It turned out that 100 % of clinically healthy cats do not have the values of AHC 6–7´104 nm2. The higher the AHC (13х104 nm2 or higher), the less likely an animal is the shelter or the initial form of kidney disease, and there is not one-hundred percent polyorganic hepatic-renal or renal-hepatic pathology. For acute renal failure, AHC values are predominantly in the range of values 13–14´104 nm2, that is, they do not differ from the norm. For chronic renal insufficiency, the value of AHC is 6–10´104 nm2. In general, for kidney diseases, there are no AHC higher than 15 nm2. In polyorganic pathology in the form of hepatic-renal and renal-hepatic AHC syndromes in domestic cats, they are 6–12x104 nm2 and are not completely found outside the given range. In combination with the results of clinical and biochemical studies of blood serum, this technique allows differentiating syndromes depending on the primary link of the pathogenetic chain. It can be used for the dispensary examination of domestic cats, as well as for the study of the animals’ health of other species in normal and in pathology.
32
Chau, Pui Hing, Jean Woo, Michael K. Gusmano, Daniel Weisz, Victor G. Rodwin, and Kam Che Chan. "Access to primary care in Hong Kong, Greater London and New York City." Health Economics, Policy and Law 8, no. 1 (May 1, 2012): 95–109. http://dx.doi.org/10.1017/s1744133112000114.
Full textAbstract:
AbstractWe investigate avoidable hospital conditions (AHC) in three world cities as a way to assess access to primary care. Residents of Hong Kong are healthier than their counterparts in Greater London or New York City. In contrast to their counterparts in New York City, residents of both Greater London and Hong Kong face no financial barriers to an extensive public hospital system. We compare residence-based hospital discharge rates for AHC, by age cohorts, in these cities and find that New York City has higher rates than Hong Kong and Greater London. Hong Kong has the lowest hospital discharge rates for AHC among the population 15–64, but its rates are nearly as high as those in New York City among the population 65 and over. Our findings suggest that in contrast to Greater London, older residents in Hong Kong and New York face significant barriers in accessing primary care. In all three cities, people living in lower socioeconomic status neighborhoods are more likely to be hospitalized for an AHC, but neighborhood inequalities are greater in Hong Kong and New York than in Greater London.
33
Bertrand, P. P., and J. J. Galligan. "Signal-transduction pathways causing slow synaptic excitation in guinea pig myenteric AH neurons." American Journal of Physiology-Gastrointestinal and Liver Physiology 269, no. 5 (November 1, 1995): G710—G720. http://dx.doi.org/10.1152/ajpgi.1995.269.5.g710.
Full textAbstract:
Intracellular recordings were obtained from myenteric AH neurons of guinea pig ileum in vitro. Slow excitatory synaptic responses associated with decreased potassium conductance (gK), inhibition of the spike afterhyperpolarization current (AHC), and increased chloride conductance (gCl) were mimicked by senktide, a neurokinin3 receptor agonist. Intracellular guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) decreased gK and increased gCl irreversibly after nerve stimulation or senktide application. Myenteric neurons in pertussis toxin (PTX)-treated tissues responded normally to senktide and nerve stimulation. Forskolin and phorbol 12,13-dibutyrate (PDBu) inhibited gK and the AHC but did not activate gCl. The AHC was not reduced by subthreshold concentrations of forskolin (10 nM) or PDBu (3 nM) alone but was inhibited by forskolin and PDBu applied together. Inhibitors of phospholipase C (D-609) or protein kinases (staurosporine) reduced slow synaptic and senktide responses. The protein phosphatase inhibitor, calyculin A, caused an inward current, a decrease in gK, and AHC inhibition but did not activate gCl. We conclude that slow excitatory synaptic responses are mediated by PTX-insensitive G proteins and activation of phospholipase C and protein kinases. Forskolin and PDBu activate pathways that inhibit gK. The mechanisms for activation of gCl are unknown.
34
Rojek, Aleksandra, Maciej R. Krawczynski, Aleksander Jamsheer, Anna Sowinska-Seidler, Barbara Iwaniszewska, Ewa Malunowicz, and Marek Niedziela. "X-Linked Adrenal Hypoplasia Congenita in a Boy due to a Novel Deletion of the EntireNR0B1 (DAX1)andMAGEB1–4Genes." International Journal of Endocrinology 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/5178953.
Full textAbstract:
X-linked Adrenal Hypoplasia Congenita (AHC) is caused by deletions or point mutations in theNR0B1 (DAX1)gene. We present a boy with AHC who came at the age of 25 days in a severe state due to prolonged vomiting and progressive dehydration. Laboratory studies showed prominent hyponatremia and hyperkaliemia but not hypoglycemia. Primary adrenal insufficiency was confirmed with low serum cortisol levels and high plasma ACTH levels. Hydrocortisone therapy combined with saline and glucose infusions was started immediately after blood collection. Two exons of theNR0B1 (DAX1)gene were impossible to amplify using the standard PCR method. Array CGH was used to confirm the putative copy-number variation ofNR0B1 (DAX1)revealing a novel hemizygous deletion encompassing the entireNR0B1 (DAX1)gene together with theMAGEBgenes. This genetic defect was also present in heterozygosity in the patient’s mother. We show thatNR0B1 (DAX1)gene analysis is important for confirmation of AHC diagnosis and highlights the role of genetic counseling in families with AHC patients, particularly those with X chromosome microdeletions, covering more thanNR0B1 (DAX1)alone. We hope that further clinical follow-up of this patient and his family will shed a new light on the role ofMAGEBgenes.
35
PANTEL, J., J. SCHRÖDER, L. R. SCHAD, M. FRIEDLINGER, M. V. KNOPP, R. SCHMITT, M. GEISSLER, S. BLÜML, M. ESSIG, and H. SAUER. "Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type." Psychological Medicine 27, no. 1 (January 1997): 221–29. http://dx.doi.org/10.1017/s003329179600431x.
Full textAbstract:
Background. The aim of the present study was to investigate neuropsychological functions in dementia of the Alzheimer type (DAT) with respect to morphological changes that were revealed by quantitative magnetic resonance imaging (MRI).Methods. Twenty patients with DAT (NINCDS-ADRDA criteria) and 10 healthy age and sex matched controls were included. The neuropsychological function was evaluated on a test battery covering the severity of dementia, verbal and visual memory, concentration and attention, language skills and general intelligence as well as activities of daily living. 3D MRI sequences were acquired using a 1.5 T Siemens MAGNETOM. Whole brain volume, total intracranial volume (TIV), volume of the frontal and temporal lobes and volumes of the amygdalahippocampus complex (AHC) were assessed using the newly developed software NMRWin.Results. Apart from TIV all morphometric parameters differed significantly between the diagnostic groups. AHC volumes discriminated best between the groups, with only a small overlap. AHC atrophy exceeded generalized atrophy. These findings were confirmed when the data were reanalysed after dividing the DAT patients into a mildly and moderately affected group. The severity of dementia was significantly correlated with the volumes of the AHC and the volumes of the temporal lobes bilaterally, but not with the whole brain volume and the volumes of the frontal lobes.Conclusions. These results underline the important role of the temporal substructures for aetiology and progression of DAT. They indicate that the volume of the AHC can be monitored by MRI and may be used to follow up the disease process.
36
Wu, Chengyuan, David W. Boorman, Richard J. Gorniak, Christopher J. Farrell, James J. Evans, and Ashwini D. Sharan. "The Effects of Anatomic Variations on Stereotactic Laser Amygdalohippocampectomy and a Proposed Protocol for Trajectory Planning." Operative Neurosurgery 11, no. 2 (April 4, 2015): 345–57. http://dx.doi.org/10.1227/neu.0000000000000767.
Full textAbstract:
Abstract BACKGROUND Stereotactic laser amygdalohippocampectomy (SLAH) is a promising minimally invasive alternative for mesial temporal lobe epilepsy. As seizure outcome has been associated with the extent of amygdalar and hippocampal ablation, it is important to select a safe trajectory optimizing involvement of both structures; however, variations in temporal anatomy significantly affect the overall complexity of planning. OBJECTIVE To quantify anatomic variables of SLAH and facilitate stereotactic planning by developing a protocol for optimally targeting the amygdalohippocampal complex (AHC). METHODS We performed a retrospective analysis of 19 SLAHs. Anatomic measurements from preoperative magnetic resonance imaging and laser trajectory measurements from coregistered postoperative magnetic resonance imaging were taken in 11 patients. Simple linear regression analysis was performed to identify significant predictor variables determining ablation extent. Based on these data, a protocol for optimal trajectory planning was developed and subsequently implemented in 8 patients. RESULTS The medial angle of the laser trajectory correlated with the medial angle of the AHC. The length of amygdalar cannulation was predictive of its ablation volume. All trajectories passed through a posteroinferior corridor formed by the lateral ventricle superiorly and collateral sulcus inferiorly. Our protocol facilitated planning and increased the volume of AHC ablation. CONCLUSION The medial AHC angle dictates the medial trajectory angle and a path from the posteroinferior corridor through the hippocampus and the center of the amygdala dictates the caudal angle. These observations led to a protocol for long-axis AHC cannulation that maintains an extraventricular trajectory to minimize hemorrhage risk and targets the center of the amygdala to optimize ablation volumes.
37
Zagaglia, Sara, Dora Steel, S. Krithika, Laura Hernandez-Hernandez, Helena Martins Custodio, Kathleen M. Gorman, Aikaterini Vezyroglou, et al. "RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood." Neurology 96, no. 11 (January 27, 2021): e1539-e1550. http://dx.doi.org/10.1212/wnl.0000000000011543.
Full textAbstract:
ObjectiveTo explore the phenotypic spectrum of RHOBTB2-related disorders and specifically to determine whether patients fulfill criteria for alternating hemiplegia of childhood (AHC), we report the clinical features of 11 affected individuals.MethodsIndividuals with RHOBTB2-related disorders were identified through a movement disorder clinic at a specialist pediatric center, with additional cases identified through collaboration with other centers internationally. Clinical data were acquired through retrospective case-note review.ResultsEleven affected patients were identified. All had heterozygous missense variants involving exon 9 of RHOBTB2, confirmed as de novo in 9 cases. All had a complex motor phenotype, including at least 2 different kinds of movement disorder, e.g., ataxia and dystonia. Many patients demonstrated several features fulfilling the criteria for AHC: 10 patients had a movement disorder including paroxysmal elements, and 8 experienced hemiplegic episodes. In contrast to classic AHC, commonly caused by mutations in ATP1A3, these events were reported later only in RHOBTB2 mutation–positive patients from 20 months of age. Seven patients had epilepsy, but of these, 4 patients achieved seizure freedom. All patients had intellectual disability, usually moderate to severe. Other features include episodes of marked skin color change and gastrointestinal symptoms, each in 4 patients.ConclusionAlthough heterozygous RHOBTB2 mutations were originally described in early infantile epileptic encephalopathy type 64, our study confirms that they account for a more expansive clinical phenotype, including a complex polymorphic movement disorder with paroxysmal elements resembling AHC. RHOBTB2 testing should therefore be considered in patients with an AHC-like phenotype, particularly those negative for ATPA1A3 mutations.
38
Amin, Paragkumar R., Jacob C. Frick, Marija Bjegovich-Weidman, Dorry Mitchell, and Jessica Tougas. "Opportunities for better management of cancer in patients receiving chemotherapy at Aurora Health Care (AHC), a large integrated health system in eastern Wisconsin." Journal of Clinical Oncology 30, no. 34_suppl (December 1, 2012): 110. http://dx.doi.org/10.1200/jco.2012.30.34_suppl.110.
Full textAbstract:
110 Background: Cancer patients, especially those on chemotherapy, have complex medical histories. They experience a variety of medical problems from their cancer and treatments. This quality improvement study is designed to collect information about chemotherapy related emergency department (ED) visits to estimate ED utilization rates, recognize patterns and evaluate other confounders. The goal is to assess and reduce ED use at AHC through improved care management. Methods: The one-year data analysis includes any patient who received chemotherapy in an outpatient care setting and had a visit to the ED within 60 days of treatment. Chemotherapy was defined by designated CPT codes combined with a primary cancer diagnosis. Every ED visit was matched to all available chemotherapy visits for each patient, retaining the chemotherapy visit nearest in chronology prior to the ED visit. Data Exclusions: (a) Patients who received chemotherapy outside AHC, and then accessed an AHC ED; (b) Patients who received inpatient chemotherapy. Results: There were 28,738 chemotherapy encounters for 4,264 unique patients system-wide. AHC EDs saw 1,669 visits for 1,048 unique patients within 60 days of chemotherapy (24.6%). The top three cancer diagnoses were 21% thoracic; 21% GI; and 16% lymph/hematopoietic. Of the 1,669 ED visits, 35% occurred within seven days and 77% within 30 days of treatment. Almost half (45.6%) of the ED visits occurred during normal office hours. No significant variation was noted by day of week. An initial focus was on the tertiary center which represented 318 (20%) of the 1,669 ED visits. The most common diagnoses for an ED visit were pain (17%) and deconditioning (17%), followed by infection (11%) and respiratory symptoms (11%). Conclusions: This study documents the ED utilization by AHC chemotherapy patients. Unexpectedly, ED use occurred frequently during normal office hours. Most visits were represented by a limited number of cancer diagnoses and presenting complaints. Intervention is planned to reduce ED use after chemotherapy at AHC through improved patient education and by shifting these visits to less expensive venues when possible.
39
BROUARD, C., P. PRADAT, E. DELAROCQUE-ASTAGNEAU, and C. SILVAIN. "Epidemiological characteristics and medical follow-up of 61 patients with acute hepatitis C identified through the hepatitis C surveillance system in France." Epidemiology and Infection 136, no. 7 (August 16, 2007): 988–96. http://dx.doi.org/10.1017/s0950268807009417.
Full textAbstract:
SUMMARYThis study aimed to describe current epidemiological and clinical characteristics, medical follow-up and outcome in the real practice of acute hepatitis C (AHC) patients. AHC cases were retrospectively identified through the French Hepatology Reference Centres Surveillance system and additional data were collected. Sixty-one patients with AHC were identified (sex ratio: M/F 1·7/1; mean age 39 years). Forty-four (72%) had documented seroconversion within a 6-month period. Main reported risk exposures were intravenous or nasal drug use (35%), invasive medical procedures (25%) and sexual contact with a HCV-positive partner (20%). Spontaneous clearance of HCV RNA was observed in seven out of 16 patients followed without therapy. This study confirms the major role of drug use in HCV transmission and highlights the role of invasive medical procedures and occupational exposure.
40
Hinton, Pamela S., Laura S. Hillman, and Rebecca D. Imhoff. "Bone Turnover in Premenopausal Women with Exercise-Associated Menstrual Disorders." Women in Sport and Physical Activity Journal 16, no. 1 (April 2007): 28–38. http://dx.doi.org/10.1123/wspaj.16.1.28.
Full textAbstract:
We compared bone mineral density and turnover in women with exercise-associated menstrual disorders (AMD, n=10; 0–9 cycles·y−1), hormonal contraceptive users (AHC, n=16; 12 cycles·y−1), and regularly menstruating controls (AE, n=13; 10–13 cycles·y−1). Thirty-nine active women (≥ 5 h aerobic exercise/wk) participated in this cross-sectional study. BMD was lower in AMD vs. AHC and AE . Serum hormone and bone turnover markers did not differ between AMD and AE. Cortisol was elevated (P=0.0002), progesterone suppressed (P=0.05), and bone alkaline phosphatase significantly lower (P=0.03) in AHC vs. AE. Lifetime missed menstrual cycles and body weight were significant, independent predictors of lumbar spine BMD, regardless of current menstrual status (adj R2=42.8%). Exercise-associated menstrual disorders have a negative effect on BMD.
41
Shreedhar, Ganga, and Susana Mourato. "Linking Human Destruction of Nature to COVID-19 Increases Support for Wildlife Conservation Policies." Environmental and Resource Economics 76, no. 4 (July 11, 2020): 963–99. http://dx.doi.org/10.1007/s10640-020-00444-x.
Full textAbstract:
Abstract This paper investigates if narratives varying the cause of the COVID-19 pandemic affects pro-wildlife conservation outcomes. In a pre-registered online experiment (N = 1081), we randomly allocated subjects to either a control group or to one of three narrative treatment groups, each presenting a different likely cause of the COVID-19 outbreak: an animal cause; an animal and human cause (AHC); and an animal, human or lab cause. We found that the AHC narrative elicited significantly greater pro-conservation policy support, especially for bans in the commercial trade of wildlife, when compared to the control group. Possible mechanisms driving this effect are that AHC narratives were less familiar, elicited higher mental and emotional engagement, and induced feelings that firms and governments are responsible for mitigating wildlife extinction.
42
Association of Professors of Medicine, APM. "Risks and Opportunities to AHC/VAMC Affiliations." American Journal of Medicine 103, no. 3 (September 1997): 173–84. http://dx.doi.org/10.1016/s0002-9343(97)00264-7.
Full text
43
Joshi, Yadav, Jong-Hun Kim, Ho Kim, and Hae-Kwan Cheong. "Impact of Drinking Water Quality on the Development of Enteroviral Diseases in Korea." International Journal of Environmental Research and Public Health 15, no. 11 (November 14, 2018): 2551. http://dx.doi.org/10.3390/ijerph15112551.
Full textAbstract:
Enterovirus diseases are fecal-orally transmitted, and its transmission may be closely related with the drinking water quality and other environmental factors. This study aimed to assess the association between environmental factors including drinking water quality and the incidence of enteroviral diseases in metropolitan provinces of Korea. Using monthly number of hand-foot-mouth disease (HFMD), aseptic meningitis (AM) and acute hemorrhage conjunctivitis (AHC) cases, generalized linear Poisson model was applied to estimate the effects of environmental factors on the monthly cases. An increase of mean temperature was associated with an increase of enteroviral diseases at 0–2 months lag, while an increase of turbidity was associated with increase in HFMD at 1 month lag and a decrease in AHC. An increase of residual chlorine in municipal drinking water was associated with a decrease in HFMD and AHC 2 and 3 months later. An increase of pH was associated with a maximum increase in AM 3 months later. The meta-analysis revealed the effects of the provincial and pooled variation in percent change of risks of environmental factors on HFMD, AM, and AHC cases at specific selected lags. This study suggests that the drinking water quality is one of the major determinants on enteroviral diseases.
44
Paudel, Navaraj, V. M. Alurkar, G. S. Jha, Ramchandra Kafle, Subash Sapkota, and Niraj Dhakal. "Apical Variant of Hypertrophic Cardiomyopathy Presenting as Recurrent Syncope and Wide Complex Tachycardia." Journal of Advances in Internal Medicine 6, no. 2 (November 6, 2017): 32–34. http://dx.doi.org/10.3126/jaim.v6i2.18539.
Full textAbstract:
Apical hypertrophic cardiomyopathy (AHC) is an uncommon variant of hypertrophic cardiomyopathy usually found as an incidental finding during routine echocardiography. It was first described by Sakamoto in 1976 in Japanese patients. Echocardiography is still considered as the best screening tool to assess AHC although MRI is considered as the gold standard for confirmation. In this case, we present a 21-year-old man with AHC who presented with recurrent brief syncopal episodes which were ignored by the patient until he was brought to us with prolonged syncope and wide complex tachycardia/ posterior fascicular ventricular tachycardia. We observed the classical findings in the plain twelve lead electrocardiograms done after cardioversion. It is always wise to keep special attention to evaluate hypertrophic cardiomyopathy (HCM) in young patients presenting with syncope.Journal of Advances in Internal Medicine 2017;06(02):32-34.
45
Posmyk, A., J. Myalski, and B. Hekner. "Composite Coatings with Ceramic Matrix Including Nanomaterials as Solid Lubricants for Oil-Less Automotive Applications." Archives of Metallurgy and Materials 61, no. 2 (June 1, 2016): 1039–43. http://dx.doi.org/10.1515/amm-2016-0175.
Full textAbstract:
Abstract The paper presents the theoretical basis of manufacturing and chosen applications of composite coatings with ceramic matrix containing nanomaterials as a solid lubricant (AHC+NL). From a theoretical point of view, in order to reduce the friction coefficient of sliding contacts, two materials are required, i.e. one with a high hardness and the other with low shear strength. In case of composite coatings AHC+NL the matrix is a very hard and wear resistant anodic oxide coating (AHC) whereas the solid lubricant used is the nanomaterial (NL) featuring a low shear strength such as glassy carbon nanotubes (GC). Friction coefficient of cast iron GJL-350 sliding against the coating itself is much higher (0.18-0.22) than when it slides against a composite coating (0.08-0.14). It is possible to reduce the friction due to the presence of carbon nanotubes, or metal nanowires.
46
Mikhaylova, K. A., V. D. Cherepanov, A. Yu Volegova, and I. E. Kuzora. "Determination of the total content of aromatic hydrocarbons by Fourier-transform IR spectroscopy in the products of diesel hydrofining." Industrial laboratory. Diagnostics of materials 86, no. 7 (July 18, 2020): 20–26. http://dx.doi.org/10.26896/1028-6861-2020-86-7-20-26.
Full textAbstract:
A comparative analysis of current methods for determination of aromatic hydrocarbons in the components of diesel fuel revealed that IR spectrometry appeared to be the most optimal method for operational control of the content of aromatic hydrocarbons in medium distillate products of the hydrogenation process. We developed a procedure for quantitative determination of aromatic hydrocarbons in the components of diesel fuel using IR Fourier spectroscopy. The analysis of absorption spectra of the components of diesel fuel revealed that the optical density of the stretching vibration band of the aromatic ring is proportional to the quantitative content of aromatic hydrocarbons (AHC) in the components of diesel fuel. One of the components for compounding diesel fuels obtained at JSC «ANKhK» during hydrotreating of raw materials under severe conditions (30 MPa, 380 – 400°C) was selected as an object of the study. Conditions of IR spectrometric analysis (wave number — 1606.5 cm–1, cell material — NaCl, absorbing layer thickness — 0.1 cm) were specified after recording of the absorption spectrum of the purified component. To construct a calibration dependence the total AHC content and corresponding optical density of the sample were determined by the methods of HPLC and IR spectrometry, respectively. The samples of hydrogenate under study (taken at different timepoints) contained 1 – 8% AHC on average depending on the parameters of a continuously operating unit. The characteristics of the proposed procedure were evaluated in accordance with the requirements of RMG 76–2014. The correctness of the obtained results of AHC determination was confirmed in comparison with the data of independent (tetrimetric) analysis. The use of the developed method in analysis of other components of diesel fuel, requires additional studies to determine the interfering substances and assess their impact on the accuracy of AHC determination.
47
Popovic, Dragana, Katarina Lalic, Aleksandra Jotic, Tanja Milicic, Jelena Bogdanovic, Maja Đorđevic, Sanja Stankovic, Veljko Jeremic, and Nebojsa M. Lalic. "The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes." Journal of Medical Biochemistry 38, no. 2 (March 3, 2019): 126–33. http://dx.doi.org/10.2478/jomb-2018-0024.
Full textAbstract:
Summary Background We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP
48
Mantovani, Giovanna, Ernesto De Menis, Giorgio Borretta, Giorgio Radetti, Sara Bondioni, Anna Spada, Luca Persani, and Paolo Beck-Peccoz. "DAX1 and X-linked adrenal hypoplasia congenita: clinical and molecular analysis in five patients." European Journal of Endocrinology 154, no. 5 (May 2006): 685–89. http://dx.doi.org/10.1530/eje.1.02132.
Full textAbstract:
Objective: Mutations in the gene coding for the orphan nuclear receptor DAX1 cause X-linked adrenal hypoplasia congenita (AHC). Affected boys usually present with primary adrenal failure in early infancy or childhood. Impaired sexual development due to hypogonadotropic hypogonadism becomes manifest at the time of puberty. Moreover, evidence from Dax1 knockout mice and a limited number of patients with AHC, suggests that mutations in DAX1 may directly cause abnormalities in spermatogenesis. The aim of this study was to characterize clinically and genetically five patients with AHC. Design: DNA sequencing analysis, endocrine testing, testicular ultrasound and semen analysis with 1-year follow-up after gonadotropin treatment. Methods: We report on five men with classic AHC manifestations. Genomic DNA was extracted from patients’ peripheral blood leukocytes and the coding region, splice sites, and promoter (−240 bp) region of DAX1 were directly sequenced. Results: Three known and two novel mutations were detected in the DAX1 coding sequence in these patients. Semen analysis was performed in four of the five patients and showed azoospermia. Twelvemonth treatment with gonadotropins did not restore fertility in these patients. All patients showed a normal testicular Doppler ultrasound, in contrast with that observed in Dax1-deficient mice, which display abnormalities in the rete testis. Conclusions: These cases further expand the number of DAX1 mutations reported in the literature, as well as our clinical knowledge of this rare disease.
49
Wang, Min, Xiaoqing Li, and Xuedong Chen. "Active Hybrid Control Algorithm with Sky-Hook Damping and Lead-Lag Phase Compensation for Multi-DOFs Ultra-Low Frequency Active Vibration Isolation System." Shock and Vibration 2017 (2017): 1–18. http://dx.doi.org/10.1155/2017/1861809.
Full textAbstract:
With the improvement of performance in the ultra-precision manufacturing engineering, the requirements for vibration isolation have become more stringent. In order to obtain a wider effective bandwidth and a higher performance of a multi-DOFs active vibration isolation system (AVIS), active hybrid control (AHC) technology is applied in this paper. AHC technology comprises a feedback active control (FBAC) technology and a feedforward active control (FFAC) technology. Absolute velocity feedback is employed to establish a sky-hook damping technology in FBAC technology. Velocity feedforward of base platform is adopted to build a lead-lag phase compensation (LLPC) technology in FFAC technology. Further, a coordinate vector conversion from unit level to system level is mentioned to describe the dynamic characteristic of the six DOFs AVIS applied in the ultra-precision field. And with the assistance of the transformed coordinate vector, the dynamic model of system level is built. Based on the establishment of the dynamic model and the research of AHC, an experimental platform which constitutes three vibration isolators and a real-time active control system is set up. The experimental results indicate that the amplitude of the resonant peak is further reduced significantly, compared to the general feedback control. And simultaneously active effective bandwidth is extended. AHC technology with sky-hook damping algorithm and LLPC control algorithm is verified to be more effective.
50
Hull, Christopher M., Myron J. Levin, Stephen K. Tyring, and Spotswood L. Spruance. "Novel Composite Efficacy Measure To Demonstrate the Rationale and Efficacy of Combination Antiviral–Anti-Inflammatory Treatment for Recurrent Herpes Simplex Labialis." Antimicrobial Agents and Chemotherapy 58, no. 3 (December 16, 2013): 1273–78. http://dx.doi.org/10.1128/aac.02150-13.
Full textAbstract:
ABSTRACTHistorically, the primary target for research and treatment of recurrent herpes simplex labialis (HSL) has been limited to inhibiting herpes simplex virus (HSV) replication. Antiviral monotherapy, however, has proven only marginally effective in curtailing the duration and severity of recurrent lesions. Recently, the role of inflammation in the progression and resolution of recurrences has been identified as an additional target. This was evaluated in a randomized study comparing combination topical 5% acyclovir-1% hydrocortisone cream (AHC) with 5% acyclovir alone (AC; in the AHC vehicle) and the vehicle. The efficacy of each topical therapy was evaluated for cumulative lesion size—a novel composite efficacy endpoint incorporating episode duration, lesion area, and proportion of nonulcerative lesions. In that study, cumulative lesion area was significantly decreased with AHC compared with AC (25% decrease;P< 0.05) and the vehicle (50% decrease;P< 0.0001). As research continues in this arena, cumulative lesion area should be included as a measure of efficacy in clinical trials of recurrent HSL therapies.