Log in

Relevant bibliographies by topics / Aging resistant / Journal articles

Journal articles on the topic 'Aging resistant'

To see the other types of publications on this topic, follow the link: Aging resistant.

Author: Grafiati

Published: 14 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Aging resistant.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Chen, Tao Ping, Biao Qiu, Na Wang, and Ru He. "Atomic Force Microscope Manifestation of Heat-Resistant Polymer Thermal Stability." Advanced Materials Research 1073-1076 (December 2014): 2267–71. http://dx.doi.org/10.4028/www.scientific.net/amr.1073-1076.2267.

Full text

Abstract:

Aimed at BH heat-resistant polymer, 4500mg/L solution is compounded by oilfield sewage, and then diluted into 1500mg/L solution by oilfield sewage again under room temperature, aging in the constant temperature box of 95°C finally. Test slides are made of different aging time BH heat-resistance polymer solution, whose thermal stability is manifested by atomic force microscope. Results show the aggregation degree of BH heat-resistant polymer solution are different after aging for 30d, 60d, 90d under 95°C. They gather largely before aging, are into a loose branch distribution. After aging for 30d, their aggregation degree declines, branch length becomes shorter. After aging for 60d, their aggregation status change greatly, are into "╫╫" shape comb distribution. After aging for 90d, they gather into about 10μm in diameter short fat wafer, and are not easy to expand.

APA, Harvard, Vancouver, ISO, and other styles

2

Bleszynski, Monika, and Maciej Kumosa. "Aging resistant TiO2/silicone rubber composites." Composites Science and Technology 164 (August 2018): 74–81. http://dx.doi.org/10.1016/j.compscitech.2018.05.035.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Shen, Quanjun, Shijie Ma, Yaohui Yang, Liang Fan, Yongzhen Li, and Pinhui Zhao. "Preparation and Performance Test of UV Resistant Composite-Modified Asphalt." Coatings 13, no. 2 (January 19, 2023): 239. http://dx.doi.org/10.3390/coatings13020239.

Full text

Abstract:

Ultraviolet radiation is the main cause of degradation in asphalt pavement. To improve the performance of the pavement used in the strong ultraviolet (UV) region of the western plateau, China, this study explores the effects of adding nano-montmorillonite and carbon black to SBS-modified asphalt. Through conventional index detection, dynamic shear rheological tests, low-temperature bending creep tests, and UV aging tests, the high- and low-temperature performance, fatigue performance, UV aging resistance, and other aspects of the asphalt were studied. Various performance and price factors were considered in the optimization of various UV resistant composite-modified asphalt formulas. Increasing the contents of nano-montmorillonite and carbon black increases the high-temperature performance and the UV aging resistance but reduces the low-temperature and fatigue performance of asphalt; hence, their total content should be limited to < 4%. Nano-montmorillonite has a better high-temperature performance and UV aging resistance than carbon black and is also less favorable to low-temperature and fatigue performance. Hence, it is recommended that its content not exceed 3%. UV resistant composite-modified asphalt has obvious advantages in high-temperature performance and UV aging resistance compared with conventional SBS-modified asphalt, and its low-temperature performance meets the use requirements of the strong-UV areas in the western plateau.

APA, Harvard, Vancouver, ISO, and other styles

4

Warman, Dwina Juliana, Huijuan Jia, and Hisanori Kato. "The Potential Roles of Probiotics, Resistant Starch, and Resistant Proteins in Ameliorating Inflammation during Aging (Inflammaging)." Nutrients 14, no. 4 (February 10, 2022): 747. http://dx.doi.org/10.3390/nu14040747.

Full text

Abstract:

Aging is typically accompanied by biological and physiological changes that alter cellular functions. Two of the most predominant phenomena in aging include chronic low-grade inflammation (inflammaging) and changes in the gut microbiota composition (dysbiosis). Although a direct causal relationship has not been established, many studies have reported significant reductions in inflammation during aging through well-maintained gut health and microbial balance. Prebiotics and probiotics are known to support gut health and can be easily incorporated into the daily diet. Unfortunately, few studies specifically focus on their significance in reducing inflammation during aging. Therefore, this review summarizes the scientific evidence of the potential roles of probiotics and two types of prebiotics, resistant starch and resistant proteins, in later age. Studies have demonstrated that the oral consumption of bacteria that may contribute to anti-inflammatory response, such as Bifidobacterium spp., Akkermansia munichipilla, and Faecalis praunitzii, contributes significantly to the suppression of pro-inflammatory markers in elderly humans and aged animals. Colonic fermentation of resistant starch and proteins also demonstrates anti-inflammatory activity owing to the production of butyrate and an improvement in the gut microbiota composition. Collectively, probiotics, resistant starch, and resistant proteins have the potential to promote healthy aging.

APA, Harvard, Vancouver, ISO, and other styles

5

Wang, Yongqiang, Zhuo Zeng, Meng Gao, and Ziye Huang. "Hygrothermal Aging Characteristics of Silicone-Modified Aging-Resistant Epoxy Resin Insulating Material." Polymers 13, no. 13 (June 29, 2021): 2145. http://dx.doi.org/10.3390/polym13132145.

Full text

Abstract:

To study the improvement effect of silicone materials on the hygrothermal resistance of epoxy resin and the aging mechanism of silicone-modified insulation materials under hygrothermal conditions, diphenylsilanediol was added to epoxy resin as a modifier in various quantities to synthesize silicone-modified epoxy resin, and a hygrothermal aging test was carried out. Water sorption, surface contact angles and dielectric properties of the insulation material were measured, and scanning electron microscope (SEM), Fourier-transform infrared spectrometry (FT-IR) and frequency domain spectroscopy (FDS) were used to analyze the results. The results showed that under 10 wt%, the silicone-modified insulation materials exhibited lower absorption rate and better dielectric properties, including lower dissipation factors and lower dielectric constant during the hygrothermal aging process, while epoxy resin modified with excessive silicone material tend to show worse dielectric performance. Closer analysis found that diphenylsilanediol decreases the size of the cracks within the material during hygrothermal aging, indicating that cracks generated during the hygrothermal aging process may be the reason for the worse dielectric performance, and diphenylsilanediol improves the hygrothermal aging resistance mainly by slowing down the generation and growth rate of cracks. FT-IR results confirmed the existence of hydrolysis and found that the rate of hydrolysis does not change with the content of diphenylsilanediol. FDS results also indicated that modified materials contain less dipoles after hygrothermal aging.

APA, Harvard, Vancouver, ISO, and other styles

6

Tecer, Hicran, Emine Acer, Harun Erol, and Mehmet Gündüz. "Effect of Aging on Conductivity of Heat Resistant Overhead Line Conductors." Materials Science Forum 765 (July 2013): 783–87. http://dx.doi.org/10.4028/www.scientific.net/msf.765.783.

Full text

Abstract:

Different kinds of Al and Al alloys are used for all bare overhead energy transmission lines. In the present work, the effect of heat treatments on the conductivity of Al-0.25wt.%Zr alloy has been investigated. Al-0.25wt.%Zr samples were prepared in cold graphite crucibles by using a vacuum furnace and a continuous casting line. The samples were aged isothermally and isochronally in muffle and tube furnaces. Aging was carried out at a wide range of temperatures (350-600 °C) at constant aging times (75 h, 100 h) and a wide range of aging times (25-500 h) at constant temperatures (425 °C, 450 °C). According to the experimental results, conductivities of aged samples increase up to a certain aging temperature and aging time and reach peak values, then decrease with increasing aging temperature and aging time.

APA, Harvard, Vancouver, ISO, and other styles

7

ZHU, Shi-Yang. "Genetic analysis on aging-resistant in rice seed." Hereditas (Beijing) 30, no. 2 (February 10, 2008): 217–24. http://dx.doi.org/10.3724/sp.j.1005.2008.00217.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Stern, Matthew M., and Jackie R. Bickenbach. "Epidermal stem cells are resistant to cellular aging." Aging Cell 6, no. 4 (August 2007): 439–52. http://dx.doi.org/10.1111/j.1474-9726.2007.00318.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Bartke, Andrzej, Liou Y. Sun, and Valter Longo. "Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity." Physiological Reviews 93, no. 2 (April 2013): 571–98. http://dx.doi.org/10.1152/physrev.00006.2012.

Full text

Abstract:

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory mice. In GH-deficient and GH-resistant animals, the “healthspan” is also extended with delays in cognitive decline and in the onset of age-related disease. The role of hormones homologous to insulin-like growth factor (IGF, an important mediator of GH actions) in the control of aging and lifespan is evolutionarily conserved from worms to mammals with some homologies extending to unicellular yeast. The combination of reduced GH, IGF-I, and insulin signaling likely contributes to extended longevity in GH or GH receptor-deficient organisms. Diminutive body size and reduced fecundity of GH-deficient and GH-resistant mice can be viewed as trade-offs for extended longevity. Mechanisms responsible for delayed aging of GH-related mutants include enhanced stress resistance and xenobiotic metabolism, reduced inflammation, improved insulin signaling, and various metabolic adjustments. Pathological excess of GH reduces life expectancy in men as well as in mice, and GH resistance or deficiency provides protection from major age-related diseases, including diabetes and cancer, in both species. However, there is yet no evidence of increased longevity in GH-resistant or GH-deficient humans, possibly due to non-age-related deaths. Results obtained in GH-related mutant mice provide striking examples of mutations of a single gene delaying aging, reducing age-related disease, and extending lifespan in a mammal and providing novel experimental systems for the study of mechanisms of aging.

APA, Harvard, Vancouver, ISO, and other styles

10

Xu, Liang, Yi He, Shaohua Ma, Li Hui, Yaoxiong Jia, and Yiming Tu. "Effects of aging process and testing temperature on the open-hole compressive properties of a carbon fiber composite." High Performance Polymers 32, no. 6 (January 8, 2020): 693–701. http://dx.doi.org/10.1177/0954008319897291.

Full text

Abstract:

The properties of T800 carbon fiber–epoxy composite specimens with a hole were studied in terms of mass change, scanning electron microscopy, glass transition temperature ( T g), heat-resistant temperature, Fourier-transform infrared (FTIR) spectroscopy, open-hole compressive strength at different temperatures, and stereomicroscopic observations after being subjected to hygrothermal aging and thermal-oxidative aging processes. FTIR spectra indicated that after hygrothermal aging at 70°C and 85% relative humidity (RH), chemical aging did not occur, whereas after thermal-oxidative aging at 190°C, the specimens exhibited chemical aging. The unaged specimens had a T g of 229°C and an extreme heat-resistant temperature T gmod of 184°C; after hygrothermal aging, the specimens had a T g and T gmod of 207°C and 143°C, respectively; and after thermal-oxidative aging, the specimens had a T g and T gmod of 252°C and 215°C, respectively. The effects of temperature on open-hole compressive strength were evaluated at room temperature of 23°C, 50°C, 100°C, 150°C, and 200°C. The compressive strengths of the specimens decreased after aging and with the increasing test temperature. At the highest test temperature, the unaged specimens, hygrothermal-aged, and thermal-oxidative-aged specimens retained over 73.7%, 65.5%, and 67.9%, respectively, of their compressive strength. Thus, the T800 carbon fiber–epoxy composite evaluated in this study exhibited good resistance to the effects of aging and high temperature. These results should be beneficial to the understanding of the long-term performance of composites.

APA, Harvard, Vancouver, ISO, and other styles

11

Zhang, Xuan, Yan Li Zhong, Xiao Wen Zhang, Lei Li, Xiao Yu Li, and Yue Yan. "Investigation of Nanomechanical and Aging Properties of Scratch-Resistant Coatings on Polycarbonate through Nanoindentation." Advanced Materials Research 704 (June 2013): 220–28. http://dx.doi.org/10.4028/www.scientific.net/amr.704.220.

Full text

Abstract:

Polycarbonate has been widely used in optical and aeronautic areas due to its low weight, transparency and high impact strength. The deposition of hard, transparent and scratch-resistant coatings on polycarbonate can significantly improve the surface mechanical behavior while capitalizing on their desirable bulk characteristics. In this work, nanomechanical properties of transparent scratch-resistant coating on polycarbonate, including nanoindentation and nanoscratch behaviors, were detailed investigated. The significant enhancement of nanomechanical response, containing hardness elastic modulus and friction-resistance, could be obtained after the deposition of the scratch-resistant coating. The results of the systematic investigation of indentation and scratch performance at the nanoscale reveal their significant differences between the surface region and bulk of coatings. Furthermore, the aging properties of scratch-resistant coatings under hygrothermal environment (65°C water for different time) can be followed-up and quantitatively detected in terms of hardness and maximum loading depth changing by nanoindentation technique, which prove to be a new and available method to study aging behavior of thin coatings.

APA, Harvard, Vancouver, ISO, and other styles

12

Li, Tianxiang, Zhengren Shi, Xianru He, Ping Jiang, Xiaobin Lu, Rui Zhang, and Xin Wang. "Aging-Resistant Functionalized LDH–SAS/Nitrile-Butadiene Rubber Composites: Preparation and Study of Aging Kinetics/Anti-Aging Mechanism." Materials 11, no. 5 (May 18, 2018): 836. http://dx.doi.org/10.3390/ma11050836.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Wang, Zhi-Chao, Yan Li, Ke-Liang Wang, Lu Wang, Bo-Sen You, Dan-Feng Zhao, Zhong-Qing Liu, et al. "miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling." Aging 12, no. 14 (July 21, 2020): 14418–33. http://dx.doi.org/10.18632/aging.103485.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Ghazali, Zahra, Eshagh Keshtkar, Majid AghaAlikhani, and Per Kudsk. "Germinability and seed biochemical properties of susceptible and non–target site herbicide-resistant blackgrass (Alopecurus myosuroides) subpopulations exposed to abiotic stresses." Weed Science 68, no. 2 (January 20, 2020): 157–67. http://dx.doi.org/10.1017/wsc.2020.9.

Full text

Abstract:

AbstractQuantifying the level of ecophysiological, biochemical, and agronomical fitness of herbicide-resistant (R) and herbicide-susceptible (S) weeds is useful for understanding the evolutionary development of herbicide resistance, but also for implementing herbicide-resistance management strategies. Although germination is a key fitness component in the life cycle of weeds, germinability of S and R weeds has rarely been evaluated under stressful conditions. Germinability traits of S and non–target site resistant subpopulations of blackgrass (Alopecurus myosuroides Huds.) sharing closely related genetic background were tested under salinity, drought stress, and accelerated seed-aging (i.e., exposed to 100% relative humidity at 45 C from 0 to 134 h) conditions. In addition, the activity of three antioxidant enzymes and protein concentration of accelerated aged seeds of the subpopulations were studied. There were no differences in maximum seed germination (Gmax) and time to 50% germination between the two subpopulations under optimum conditions. However, under salinity, drought stress, and accelerated aging conditions, there were differences between the subpopulations. The salinity, drought, and accelerated aging treatments reducing Gmax of the S subpopulation by 50% were 18 dS m−1, 0.75 MPa, and 90 h, respectively, while for the R subpopulation the corresponding values were 15 dS m−1, 0.66 MPa, and 67 h. No differences were found in the activity of the antioxidant enzymes and the content of protein between non-aged seeds of the subpopulations. The aging treatments reducing the activity of catalase and superoxide dismutase enzymes by 50% were 118 and 82 h for the S subpopulation, respectively, while they were 54 and 58 h for the R subpopulation. In contrast, there were no differences in the effect of the aging treatments on the peroxidase activity and protein content between subpopulations. The results provided clear evidence that the non–target site resistant loci of blackgrass is associated with fitness costs under environmental stress.

APA, Harvard, Vancouver, ISO, and other styles

15

Wang, Zhi-Chao, Yan Li, Ke-Liang Wang, Lu Wang, Bo-Sen You, Dan-Feng Zhao, Zhong Qing Liu, et al. "Retraction: miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling." Aging 12, no. 20 (October 31, 2020): 20930. http://dx.doi.org/10.18632/aging.104212.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Serrano, R., J. Barrenetxe, J. Orbe, J. A. Rodríguez, N. Gallardo, C. Martínez, A. Andrés, and J. A. Páramo. "Tissue-specific PAI-1 gene expression and glycosylation pattern in insulin-resistant old rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297, no. 5 (November 2009): R1563—R1569. http://dx.doi.org/10.1152/ajpregu.00093.2009.

Full text

Abstract:

Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with obesity, aging, insulin resistance, and type 2 diabetes, conditions that contribute to increased cardiovascular risk. PAI-1 is expressed in a variety of tissues, but the cellular origin of plasma PAI-1 is unknown. To link insulin resistance, aging, and cardiovascular disease, we examined the expression and glycosylation pattern of PAI-1 in liver and white adipose tissue (WAT) from adult (3 mo) and insulin-resistant old (24 mo) Wistar rats. Glycosylated PAI-1 protein was also purified by affinity chromatography from endothelial culture supernatans to analyze its inhibitory activity. We also analyzed the contribution of adipocytes and stromal vascular cells from WAT to PAI-1 levels with aging. Aging caused a significant increase of PAI-1 mRNA ( P < 0.001) in WAT that was predominantly due to the adipocytes and not to stroma-vascular cells, while there was no modification in liver from aged rats. Moreover, PAI-1 expression increased during preadipocyte differentiation ( P < 0.001). Furthermore, we found a tissue-dependent PAI-1 glycosylation pattern: adipose tissue only expresses the glycosylated PAI-1 form, whereas the liver mainly expresses the nonglycosylated form. Finally, we also found evidences suggesting that the glycosylated PAI-1 form shows higher inhibitory activity than the nonglycosylated. Our data suggest that WAT may be a major source of the elevated plasma levels of PAI-1 in insulin-resistant old rats. Additionally, the high degree of PAI-1 glycosylation and activity, together with the significant increase in visceral fat in old rats, may well contribute to an increased cardiovascular risk associated with insulin-resistant states.

APA, Harvard, Vancouver, ISO, and other styles

17

Cao, Hongwen, Dan Wang, Peng Sun, Lei Chen, Yigeng Feng, and Renjie Gao. "Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis." Aging 13, no. 19 (October 6, 2021): 23096–107. http://dx.doi.org/10.18632/aging.203602.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Sustaita-Torres, Ireri A., Sergio Haro-Rodríguez, and Rafael Colás. "Aging of a Low Carbon Heat Resistant Cast Alloy." High Temperature Materials and Processes 37, no. 2 (January 26, 2018): 133–39. http://dx.doi.org/10.1515/htmp-2016-0112.

Full text

Abstract:

AbstractThe changes in microstructure that take place during aging a low carbon heat resistant alloy at 750°C for a period of time of up to 1,000 h were studied by optical and scanning electron microscopy, X-ray diffraction and mechanical testing. The microstructure of the as-cast alloy consisted of an austenitic matrix and a network of Nb- and Cr-rich primary carbides that were identified by their tonality when viewed in backscattered mode in a scanning electron microscopy. Aging promotes precipitation of secondary carbides and the transformation of the Nb-rich particles. The mechanical properties are affected by the occurrence of the different phenomena.

APA, Harvard, Vancouver, ISO, and other styles

19

Sakib, Sadman, Aleksandar Milenkovic, Md Tauhidur Rahman, and Biswajit Ray. "An Aging-Resistant NAND Flash Memory Physical Unclonable Function." IEEE Transactions on Electron Devices 67, no. 3 (March 2020): 937–43. http://dx.doi.org/10.1109/ted.2020.2968272.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Fu, Ye, Detao Zhao, Wencai Wang, and Yuri Lvov. "Aging Resistant Elastomer Reinforcement by Antioxidant Loaded Clay Nanotubes." IOP Conference Series: Materials Science and Engineering 64 (August 22, 2014): 012047. http://dx.doi.org/10.1088/1757-899x/64/1/012047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Sustaita-Torres, Ireri A., Sergio Haro-Rodríguez, Martha P. Guerrero-Mata, Maribel de la Garza, Eduardo Valdés, Frederic Deschaux-Beaume, and Rafael Colás. "Aging of a cast 35Cr–45Ni heat resistant alloy." Materials Chemistry and Physics 133, no. 2-3 (April 2012): 1018–23. http://dx.doi.org/10.1016/j.matchemphys.2012.02.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Lee, Dongju, Jin-Ju Park, Min-Ku Lee, and Gyoung-Ja Lee. "Aging-resistant nanofluids containing covalent functionalized boron nitride nanosheets." Nanotechnology 28, no. 40 (September 11, 2017): 405704. http://dx.doi.org/10.1088/1361-6528/aa8615.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Tomás-Loba, Antonia, Ignacio Flores, Pablo J. Fernández-Marcos, María L. Cayuela, Antonio Maraver, Agueda Tejera, Consuelo Borrás, et al. "Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice." Cell 135, no. 4 (November 2008): 609–22. http://dx.doi.org/10.1016/j.cell.2008.09.034.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Zhang, Chen, Xiyi Lu, Xinyin Liu, Jiali Xu, Jun Li, Tianyu Qu, Jiali Dai, and Renhua Guo. "Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer." Oxidative Medicine and Cellular Longevity 2023 (January 31, 2023): 1–21. http://dx.doi.org/10.1155/2023/1367938.

Full text

Abstract:

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI, such as gefitinib) in lung cancer continues to be a major problem. Recent studies have shown the promise of ferroptosis-inducing therapy in EGFR-TKI resistant cancer, but have not been translated into clinical benefits. Here, we identified carbonic anhydrase IX (CA9) was upregulated in gefitinib-resistant lung cancer. Then we measured the cell viability, intracellular reactive oxygen species (ROS) levels, and labile iron levels after the treatment of ferroptosis inducer erastin. We found that CA9 confers resistance to ferroptosis-inducing drugs. Mechanistically, CA9 is involved in the inhibition of transferrin endocytosis and the stabilization of ferritin, leading to resistance to ferroptosis. Targeting CA9 promotes iron uptake and release, thus triggering gefitinib-resistant cell ferroptosis. Notably, CA9 inhibitor enhances the ferroptosis-inducing effect of cisplatin on gefitinib-resistant cells, thus eliminating resistant cells in heterogeneous tumor tissues. Taken together, CA9-targeting therapy is a promising approach to improve the therapeutic effect of gefitinib-resistant lung cancer by inducing ferroptosis.

APA, Harvard, Vancouver, ISO, and other styles

25

Liu, Pan. "Artificial Aging Test Analysis of Alkyd and Polyurethane Coating System." Advanced Materials Research 496 (March 2012): 116–20. http://dx.doi.org/10.4028/www.scientific.net/amr.496.116.

Full text

Abstract:

Paint aging will take a long time under the conditions of natural exposure, their failure mechanism can't be known quickly. So the artificial UV-condensation accelerated aging test is used to alkyd system and polyurethane system, and the coating aging was analyzed by using SEM, gloss meter and FTIR. The results shown that their failure mechanism is different, the main reason that life of alkyd system was lower than polyurethane system is its weak water-resistant. If the water-resistant of alkyd system can be improved, the use area of alkyd system will be expanded.

APA, Harvard, Vancouver, ISO, and other styles

26

Piloto, Juan H., Michael Rodriguez, and Keith P. Choe. "Sexual dimorphism in Caenorhabditis elegans stress resistance." PLOS ONE 17, no. 8 (August 11, 2022): e0272452. http://dx.doi.org/10.1371/journal.pone.0272452.

Full text

Abstract:

Physiological responses to the environment, disease, and aging vary by sex in many animals, but mechanisms of dimorphism have only recently begun to receive careful attention. The genetic model nematode Caenorhabditis elegans has well-defined mechanisms of stress response, aging, and sexual differentiation. C. elegans has males, but the vast majority of research only uses hermaphrodites. We found that males of the standard N2 laboratory strain were more resistant to hyperosmolarity, heat, and a natural pro-oxidant than hermaphrodites when in mixed-sex groups. Resistance to heat and pro-oxidant were also male-biased in three genetically and geographically diverse C. elegans strains consistent with a species-wide dimorphism that is not specific to domestication. N2 males were also more resistant to heat and pro-oxidant when keep individually indicating that differences in resistance do not require interactions between worms. We found that males induce canonical stress response genes by similar degrees and in similar tissues as hermaphrodites suggesting the importance of other mechanisms. We find that resistance to heat and pro-oxidant are influenced by the sex differentiation transcription factor TRA-1 suggesting that downstream organ differentiation pathways establish differences in stress resistance. Environmental stress influences survival in natural environments, degenerative disease, and aging. Understanding mechanisms of stress response dimorphism can therefore provide insights into sex-specific population dynamics, disease, and longevity.

APA, Harvard, Vancouver, ISO, and other styles

27

Zhang, Ruijie, Xiaoyan Liu, Zhaopeng Wang, and Fei Gao. "Effects of interrupted aging on the intergranular corrosion behavior of Al–Cu–Mg–Ag heat-resistant alloy." World Journal of Engineering 13, no. 6 (December 5, 2016): 476–81. http://dx.doi.org/10.1108/wje-09-2016-0079.

Full text

Abstract:

Purpose The purpose of this study is to research the effects of interrupted aging on the corrosion behavior of Al–Cu–Mg–Ag heat-resistant alloy by means of intergranular corrosion (IGC) testing, potentiodynamic polarization combined with optical microscopy and transmission electron microscopy. Design/methodology/approach The results show that the IGC began on the grain boundaries and continued along the grain boundary. The corrosion resistance property of Al–Cu–Mg–Ag alloy was enhanced by interrupted aging. The precipitations of the interrupted aged sample both in the grains and on the grain boundaries were fine, and the chain-like phases on the grain boundary were distributed nearly continuously. Findings The corrosion resistance of Al–Cu–Mg series Al alloy with equilibrium phase (Al2Cu) is notably determined by precipitation-free zone (PFZ) as the self-corrosion potentials of (Al2Cu), PFZ and the matrix satisfied the relation EPFZ < Eθ<EMatrix. Originality/value The connections of the PFZ on both sides of the grain boundary decreased the corrosion resistance of Al–Cu–Mg–Ag alloy treated by the single aging.

APA, Harvard, Vancouver, ISO, and other styles

28

Radziszewski, Piotr. "MODIFIED ASPHALT MIXTURES RESISTANCE TO PERMANENT DEFORMATIONS." JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT 13, no. 4 (December 31, 2007): 307–15. http://dx.doi.org/10.3846/13923730.2007.9636451.

Full text

Abstract:

Permanent deformations, primarily in the form of ruts, are one of the basic asphalt pavement damages impairing its service properties. Application of appropriate asphalt mixtures and binder modification are effective methods for improving asphalt courses resistance. While being manufactured, stored, fitted into a road pavement and during long term service, bitumen binders and asphalt mixtures are subject to continuous unfavourable ageing processes during which pavement courses characteristics change considerably, resistance to permanent deformations being among them. This article presents rut and dynamic creep test results of concrete, SMA (stone mastic asphalt), MNU (thin courses of non‐continuous grain mixtures), Superpave mixture and porous asphalt mixture of two air void content percentages: 15 %, 20 %. Asphalt concrete mixtures, MNU's and porous asphalt mixtures contained elastomer, plastomer and fine rubber modified binders. Samples for laboratory rut tests were made by slab compaction because this method, as the author's previous research had shown, was the closest to ‘in‐situ’ conditions. Resistance to permanent deformations of the examined specimens was evaluated before aging, after technological aging (short term ageing) and after service ageing (long‐term ageing). The test results show that resistance to permanent deformations depends on the kind of asphalt mixture and binder applied. Concrete asphalts with fine rubber modified bitumens and concrete asphalts with 7 % polymer modified binders as well as SMA's and Superpave mixtures with unmodified binders appeared to be most resistant to permanent deformations after a long‐term laboratory ageing. It was proved that the overall evaluation of resistance to permanent deformations could be obtained by rut and creep testing of asphalt mixtures exposed to short‐ and long‐term ageing. Simultaneous determining 4 parameters: maximum rut depth after short‐term ageing, rutting coefficient after operational ageing, stiffness creeping modulus after long‐term ageing and cumulated deformation after short‐term ageing, facilitates full characteristics of modified asphalt mixes designed to be built in the wearing course of a road pavement.

APA, Harvard, Vancouver, ISO, and other styles

29

Wang, Jin San. "Kinetic and Strength Calculation of Age-Hardening Phases in Heat-Resistant Aluminum Alloys with Silver." Materials Science Forum 993 (May 2020): 1051–56. http://dx.doi.org/10.4028/www.scientific.net/msf.993.1051.

Full text

Abstract:

In order to study the microstructures of heat-resistant aluminium alloys with silver in process of aging, kinetic and strength calculation were used to study the equilibrium and metastable phases of Al-4Cu-0.3Mg-0.4Ag alloy system. The main equilibrium phases were Liquid phase, α-Al matrix phase, Al2Cu phase, S phase (Al2CuMg) and AgMg phase, while metastable strengthening phases were Ω phase and θ’ phase. In addition, the kinetic parameters and aging strength of_Ω phase and θ’ phase that precipitated during aging were calculated. The calculated results shows that Ω phase has higher heat-resistant strengthening effect than θ’ phase.

APA, Harvard, Vancouver, ISO, and other styles

30

Sosa Lissarrague, Matías Humberto, and César Armando Lanz. "NbC TRANSFORMATION DURING AGING IN HP40-Nb HEAT RESISTANT ALLOY." Acta Metallurgica Slovaca 28, no. 3 (September 24, 2022): 147–50. http://dx.doi.org/10.36547/ams.28.3.1562.

Full text

Abstract:

In this work, the evolution of MC-type Nb-rich primary carbides in a 35Ni-25Cr-Nb-type refractory alloy, commonly known as HP40-Nb, and its transformation into Ni-Nb silicide known as G-phase (Ni16Nb6Si7), has been studied. For this purpose, the experimental technique of scanning electron microscopy was used together with X-ray microanalysis to detect changes in the chemical composition of niobium carbide over time and at a given aging temperature. The microstructure of the studied alloy, in its as-cast condition, consists of an austenitic matrix strengthened by a network of primary eutectic-like carbides rich in chromium and niobium of the M23C6 and MC types, respectively. During aging of the alloy at high temperatures, microstructural changes take place such as the secondary precipitation of M23C6 type carbides and the transformation of the primary Nb-rich carbide towards the Ni-Nb-rich silicide. It has been found that the transformation begins at the interface of the niobium carbides with the matrix, progressing towards their interior with the development of aging.

APA, Harvard, Vancouver, ISO, and other styles

31

Haidemenopoulos, G. N., K. Polychronopoulou, A. D. Zervaki, H. Kamoutsi, S. I. Alkhoori, S. Jaffar, P. Cho, and H. Mavros. "Aging Phenomena during In-Service Creep Exposure of Heat-Resistant Steels." Metals 9, no. 7 (July 19, 2019): 800. http://dx.doi.org/10.3390/met9070800.

Full text

Abstract:

An investigation of aging phenomena during creep exposure has been conducted for HP-Nb cast reformer tubes for several exposure conditions. Aging was manifested by carbide precipitation, carbide coarsening, and carbide transformation. The transformation of primary M7C3 to the more stable M23C6 carbide takes place at high exposure temperature (910 °C and above). The primary MC carbides transform to the Ni-Nb silicide or G-phase during creep exposure. The presence of Ti in the steel prevented the transformation of MC carbides to the G-phase. Morphological changes like needle to globular transitions, rounding of carbide edges, and carbide coarsening take place during creep exposure. The room-temperature tensile elongation and ultimate tensile strength are significantly reduced during creep exposure. The above aging phenomena are precursors to creep damage.

APA, Harvard, Vancouver, ISO, and other styles

32

Jeon, J. Y., R. L. Bradley, E. G. Kokkotou, F. E. Marino, X. Wang, P. Pissios, and E. Maratos-Flier. "MCH-/- Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance." Diabetes 55, no. 2 (January 27, 2006): 428–34. http://dx.doi.org/10.2337/diabetes.55.02.06.db05-0203.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Kim, Chanmi, Iqra Latif, Durga P. Neupane, Gi Young Lee, Ryan S. Kwon, Alia Batool, Qasim Ahmed, Muhammad Usman Qamar, and Jeongmin Song. "The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients." PLOS ONE 16, no. 9 (September 28, 2021): e0257744. http://dx.doi.org/10.1371/journal.pone.0257744.

Full text

Abstract:

Sepsis is a syndromic response to infections and is becoming an emerging threat to the public health sector, particularly in developing countries. Salmonella Typhi (S. Typhi), the cause of typhoid fever, is one primary cause of pediatric sepsis in typhoid endemic areas. Extensively drug-resistant (XDR) S. Typhi is more common among pediatric patients, which is responsible for over 90% of the reported XDR typhoid cases, but the majority of antibiotic resistance studies available have been carried out using S. Typhi isolates from adult patients. Here, we characterized antibiotic-resistance profiles of XDR S. Typhi isolates from a medium size cohort of pediatric typhoid patients (n = 45, 68.89% male and 31.11% female) and determined antibiotic-resistance-related gene signatures associated with common treatment options to typhoid fever patients of 18 XDR S. Typhi representing all 45 isolates. Their ages were 1–13 years old: toddlers aging 1–2 years old (n = 9, 20%), pre-schoolers aging 3–5 years old (n = 17, 37.78%), school-age children aging 6–12 years old (n = 17, 37.78%), and adolescents aging 13–18 years old (n = 2, 4.44%). Through analyzing blaTEM1, dhfR7, sul1, and catA1genes for multidrug-resistance, qnrS, gyrA, gyrB, parC, and parE for fluoroquinolone-resistance, blaCTX-M-15 for XDR, and macAB and acrAB efflux pump system-associated genes, we showed the phenotype of the XDR S. Typhi isolates matches with their genotypes featured by the acquisitions of the genes blaTEM1, dhfR7, sul1, catA1, qnrS, and blaCTX-M-15 and a point mutation on gyrA. This study informs the molecular basis of antibiotic-resistance among recent S. Typhi isolates from pediatric septicemia patients, therefore providing insights into the development of molecular detection methods and treatment strategies for XDR S. Typhi.

APA, Harvard, Vancouver, ISO, and other styles

34

Scheffold, Annika, Ali H. Baig, Zhiyang Chen, Sarah E. von Löhneysen, Friedrich Becker, Yohei Morita, Alush I. Avila, et al. "Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells." Leukemia 34, no. 4 (November 14, 2019): 1125–34. http://dx.doi.org/10.1038/s41375-019-0641-3.

Full text

Abstract:

AbstractAccumulation of DNA damage and myeloid-skewed differentiation characterize aging of the hematopoietic system, yet underlying mechanisms remain incompletely understood. Here, we show that aging hematopoietic progenitor cells particularly of the myeloid branch exhibit enhanced resistance to bulky DNA lesions—a relevant type of DNA damage induced by toxins such as cancer drugs or endogenous aldehydes. We identified aging-associated activation of the Hedgehog (Hh) pathway to be connected to this phenotype. Inhibition of Hh signaling reverts DNA damage tolerance and DNA damage-resistant proliferation in aged hematopoietic progenitors. Vice versa, elevating Hh activity in young hematopoietic progenitors is sufficient to impair DNA damage responses. Altogether, these findings provide experimental evidence for aging-associated increases in Hh activity driving DNA damage tolerance in myeloid progenitors and myeloid-skewed differentiation. Modulation of Hh activity could thus be explored as a therapeutic strategy to prevent DNA damage tolerance, myeloid skewing, and disease development in the aging hematopoietic system.

APA, Harvard, Vancouver, ISO, and other styles

35

Gu, Naibing, Xinlai Wang, Zhengli Di, Jing Xiong, Yue Ma, Yu’e Yan, Yihua Qian, Quanzeng Zhang, and Jia Yu. "Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis." Aging 11, no. 22 (November 26, 2019): 10266–83. http://dx.doi.org/10.18632/aging.102455.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Pi, Jin Hong, Zhang Zhong Wang, Xiu Ming Zhao, and Hai Feng Wu. "Study on Anti-Stress Relaxation Behavior of Non-Quenched Steel." Advanced Materials Research 785-786 (September 2013): 8–11. http://dx.doi.org/10.4028/www.scientific.net/amr.785-786.8.

Full text

Abstract:

The cold draw MFT8 steels with different reduction in cross sectional areas were investigated to understand the effect of aging time on the anti-stress relaxation ability of non-quenched and tempered steel. The hardness and the anti-stress relaxation ability of cold draw NQT MFT8 steel was improved after aging at 300°Csince the precipitation of submicron particles within deformed ferrite. The cold draw NQT MFT8 becomes harder and more resistant to stress relaxation with increasing aging time. The cold draw MFT8 with both 25% and 30% reduction in cross sectional areas are stress relaxation resistant after aged at 300°C for 2 hours.

APA, Harvard, Vancouver, ISO, and other styles

37

Xin, Qian, Qinghong Ji, Ying Zhang, Weihong Ma, Baoqing Tian, Yanli Liu, Yunsong Chen, et al. "Aberrant ROS Served as an Acquired Vulnerability of Cisplatin-Resistant Lung Cancer." Oxidative Medicine and Cellular Longevity 2022 (June 20, 2022): 1–17. http://dx.doi.org/10.1155/2022/1112987.

Full text

Abstract:

Lung cancer has become a global health issue in recent decades. Approximately 80-85% of cases are non-small-cell lung cancer (NSCLC). Despite the high rate of resistance, cisplatin-base chemotherapy is still the main treatment for NSCLC patients. Thus, overcoming cisplatin resistance is urgently needed in NSCLC therapy. In this study, we identify NADPH metabolism and reactive oxygen species (ROS) levels as the main causes accounting for cisplatin resistance. Based on a small panel consisting of common chemotherapy drugs or compounds, APR-246 is proved to be an effective compound targeting cisplatin-resistant NSCLC cells. APR-246 specially inhibits proliferation and colony formation of cisplatin-resistant cells. In details, APR-246 can significantly cause G0/G1 accumulation and S phase arrest of cisplatin resistant cells and gives rise to severe mitochondria dysfunction as well as elevated apoptosis. Further study proves that it is the aberrant ROS levels as well as NRF2/SLC7A11/GSH axis dysfunction accounting for the specific antitumor effects of APR-246. Scavenging ROS with N-acetylcysteine (NAC) disrupts the inhibitory effect of APR-246 on cisplatin-resistant cells. Mechanistically, NRF2 is specifically degraded by the proteasome following its own ubiquitylation in APR-246-treated cisplatin-resistant cells, which in turn decreases NRF2/SLC7A11/GSH axis activity. Our study provides new insights into the biology driving cisplatin resistance of lung cancer and highlights APR-246 as a potential therapeutic reagent for overcoming cisplatin resistance.

APA, Harvard, Vancouver, ISO, and other styles

38

Yu, Hong Yao, Cheng Yu Chi, Jian Xin Dong, and Xi Shan Xie. "650°C Long-Term Structure Stability Study on 18Cr10NiNb Heat-Resistant Steel." Advanced Materials Research 399-401 (November 2011): 180–84. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.180.

Full text

Abstract:

The Nb-contained austenitic heat-resistant steel 18Cr10NiNb(TP347H) has been widely used as super-heater and re-heater tube material for modern ultra-super-critical (USC) power plants in the world. High temperature structure stability is considered to be one of the most important factors for long-term service. Long-term aging at 650 °C for this steel was conducted till 10,000 hours. Effect of aging time on microstructure was studied by means of SEM and TEM. Tensile tests were carried out after aging at 650 °C for different times. Experimental results show that MX phase and M23C6 carbides are major strengthening precipitates in this steel. With increasing of aging time, fine nano-size MX particles precipitate in grains and its size keeps about 50 nm till 10,000 h at 650 °C. Carbide M23C6 mainly precipitates at grain boundaries but coarsens quickly. Investigation results show that MX phase plays the most important strengthening effect in grains. The amount of MX phase increases with increasing of Nb and C contents. The effects of Nb and C contents on mole fractions of MX phase in 18Cr10NiNb steel have been calculated by using Thermo-Calc software.

APA, Harvard, Vancouver, ISO, and other styles

39

Guo, Ting, Chao Gu, Bin Li, and Congjian Xu. "Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain." Aging 13, no. 15 (August 5, 2021): 19750–59. http://dx.doi.org/10.18632/aging.203386.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Yu, Hong Yao, Jian Xin Dong, and Xi Shan Xie. "650°C Long-Term Structure Stability Study on 18Cr-9Ni-3CuNbN Heat-Resistant Steel." Materials Science Forum 654-656 (June 2010): 118–21. http://dx.doi.org/10.4028/www.scientific.net/msf.654-656.118.

Full text

Abstract:

The Cu-containing austenitic heat-resistant steel 18Cr-9Ni-3CuNbN has been widely used as superheater and reheater tube material for modern ultra-super-critical (USC) power plants in the world. High temperature structure stability is considered to be an important factor for long-term service. Long-term aging at 650°C for this steel was conducted from 100 to 10,000hours. Effect of aging time on microstructure was studied by means of SEM, TEM and 3DAP (three dimensional atom probe). Micro-hardness tests were carried out after aging at 650°C for different times to be considered as a representative of strength. Experimental results show that Cu-rich phase, MX and M23C6 are major strengthening precipitates in this steel. With on increasing of aging time, fine nano-size Cu-rich phase particles precipitate in the grains and its size is in the range of several nanometers to 35nm till 10,000h at 650°C. The fraction of MX also increases with aging time and its average size is about 100nm till 10,000h. Carbide M23C6 mainly precipitates at grain boundaries and coarsens quickly. Investigation results show that the most important strengthening effect for 18Cr-9Ni-3CuNbN steel is contributed by Cu-rich phase and MX in the grains and M23C6 carbide at the grain boundaries.

APA, Harvard, Vancouver, ISO, and other styles

41

Benalcázar Jalkh, E. B., P. G. Coelho, L. Witek, E. T. P. Bergamo, A. C. O. Lopes, K. N. Monteiro, P. F. Cesar, et al. "Nanoscale physico-mechanical properties of an aging resistant ZTA composite." Journal of the Mechanical Behavior of Biomedical Materials 123 (November 2021): 104690. http://dx.doi.org/10.1016/j.jmbbm.2021.104690.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Gökalp, İslam, and Volkan Emre Uz. "Sustainable Production of Aging-Resistant Bitumen: Waste Engine Oil Modification." Journal of Transportation Engineering, Part B: Pavements 147, no. 4 (December 2021): 04021055. http://dx.doi.org/10.1061/jpeodx.0000315.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Wang, Chunxin, Chenchi Qu, Jianshe Chen, Binchuan Li, Kuiren Liu, and Qing Han. "Performance of aging-treated heat-resistant Al–Cu–Sc wires." Materials Letters 315 (May 2022): 132008. http://dx.doi.org/10.1016/j.matlet.2022.132008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Vafaie, Faran, Hao Yin, Caroline O'Neil, Zengxuan Nong, Alanna Watson, John-Michael Arpino, Michael W. A. Chu, David Wayne Holdsworth, Robert Gros, and J. Geoffrey Pickering. "Collagenase-resistant collagen promotes mouse aging and vascular cell senescence." Aging Cell 13, no. 1 (September 19, 2013): 121–30. http://dx.doi.org/10.1111/acel.12155.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Viherkoski, M., E. Huttunen-Saarivirta, E. Isotahdon, M. Uusitalo, T. Tiainen, and V. T. Kuokkala. "The effect of aging on heat-resistant cast stainless steels." Materials Science and Engineering: A 589 (January 2014): 189–98. http://dx.doi.org/10.1016/j.msea.2013.09.074.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Axelsson, S. "Physical bioenergetics of degradation-resistant proteins in diseases and aging." Medical Hypotheses 51, no. 1 (July 1998): 47–51. http://dx.doi.org/10.1016/s0306-9877(98)90253-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Fu, Ye, Detao Zhao, Pengjun Yao, Wencai Wang, Liqun Zhang, and Yuri Lvov. "Highly Aging-Resistant Elastomers Doped with Antioxidant-Loaded Clay Nanotubes." ACS Applied Materials & Interfaces 7, no. 15 (April 8, 2015): 8156–65. http://dx.doi.org/10.1021/acsami.5b00993.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Feng, Xinyang, Jia Guo, Hannah C. Sigmon, Richard P. Sloan, Adam M. Brickman, Frank A. Provenzano, and Scott A. Small. "Brain regions vulnerable and resistant to aging without Alzheimer’s disease." PLOS ONE 15, no. 7 (July 29, 2020): e0234255. http://dx.doi.org/10.1371/journal.pone.0234255.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Manikandan, Palanisamy. "Carbapenem-resistant biofilm-producing multidrug resistant Klebsiella pneumoniae induced hospital-acquired infections and analysis of resistant genes." Majmaah Journal of Health Sciences 11, no. 1 (2023): 161. http://dx.doi.org/10.5455/mjhs.2023.01.013.

Full text

Abstract:

In recent years, drug resistance has caused a significant number of fatalities. This review focuses on the emergence of medication resistance in Klebsiella pneumoniae strains associated with biofilm development, neonatal sepsis, aging, and secondary K. pneumoniae infection in COVID-19 cases. This review is an exclusive survey of >200 research articles and >100 review articles indexed in the Web of Science list with the keywords “K. pneumoniae,” “drug resistance,” “sepsis,” “neonatal sepsis,” “sepsis in older age,” “secondary infection,” “biofilm production,” “secondary infection in COVID-19,” “drug resistance genes,” and “whole genome sequencing”. In order to protect antibiotic susceptibility and to provide an overview of the biofilm forming mechanisms among gram-negative bacteria, the review discusses the function of multidrug-resistant K. pneumoniae in the production of biofilms. Additionally, K. pneumoniae’s role in contemporary cases of sepsis, spread of medication resistance in hospitals, and sepsis caused by K. pneumoniae in the geriatric age group are discussed. A summary of current approaches and the identification of drug resistance genes utilizing a whole genome sequencing technique are also reviewed in this article.

APA, Harvard, Vancouver, ISO, and other styles

50

Biondo-Simões, Maria de Lourdes Pessole, Oreste Terranova, Sergio Ossamu Ioshii, Karin Soldatelli Borsato, Janaína Weingärtner, Gustavo Nogueira, and Patrícia Longhi. "Effects of aging on abdominal wall healing in rats." Acta Cirurgica Brasileira 20, no. 2 (April 2005): 124–33. http://dx.doi.org/10.1590/s0102-86502005000200005.

Full text

Abstract:

PURPOSE: The aim of this study was to assess abdominal wall healing in old and young adult rats. METHODS: On average, young animals were 110 days old and old animals were 762 days old. A 4.0 cm median laparotomy was performed under anesthesia, followed by laparorrhaphy on two synthesis planes, i.e. peritoneum-muscle-aponeurosis and skin, using continuous 5.0 nylon sutures. The animals were evaluated on the 3rd, 7th, 14th and 21st postoperative days. The resistance of the two planes was studied separately and a histopathologic analysis was performed on sections stained with hematoxylin-eosin and Sirius Red. Immunohistochemical analysis was also carried out using PCNA, LCA and CD34. RESULTS: The skin scars gained resistance in a similar manner at the initial time points, but those of young rats were more resistant on the 21st day (p=0.0029). Total and type III collagen content was similar in the two groups and type I collagen content was higher in young animals on the 14th day. Inflammatory cell infiltration was more marked in the skin wounds of young animals on the 3rd day (p=0.0190). Reepithelialization was similar and angiogenesis was more intense in the skin wounds of young animals on the 14th day (p=0.0062). The peritoneum-muscle-aponeurosis wounds gained similar resistance during the early phases, but were more resistant on the 14th day (p=0.0005) and on the 21st day (p=0.0023) in old rats Collagen concentration was higher in the wounds of old animals on the 3rd day (p=0.0112) and in the wounds of young animals on the 21st day (p=0.0348). The inflammatory reaction was more intense in the wounds of old animals on the 3rd day (p=0.0060) and angiogenesis was more intense on the 14th day (0.0432). CONCLUSION: Although there are some differences in the healing course between young and old animals, age, of itself, does not impair the healing of abdominal wall wounds in rats.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!