Academic literature on the topic 'Aggressiveness profile'
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Journal articles on the topic "Aggressiveness profile"
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Burian, Rosemarie Anne, Tobias Appenzeller, Philipp Oertle, Christian Raez, Roderick Y. H. Lim, Serafino Forte, Sophie Dellas, Ellen Obermann, and Marija Plodinec. "Nanomechanical profiling of human breast tumors as prognostic marker for breast cancer." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 11618. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.11618.
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11618 Background: Assessment of tumor aggressiveness is crucial when making treatment decisions. Established prognostic markers may be insufficient to stratify cancer patients into treatment relevant risk groups. Emerging evidence indicates mechanical properties of cancer cells and their microenvironment play a vital role in cancer invasion and metastases. Detecting and measuring these nanomechanical changes could be a marker of cancer aggressiveness. Methods: We developed an atomic force microscope (AFM) based method: ARTIDIS (Automated and Reliable Tissue Diagnostics) for measuring nanomechanical properties of human tissue biopsies. These were performed on fresh, non-fixed tissue under physiological conditions. This novel method uses a micro-fabricated 20nm tip indenting and measuring stiffness of thousands of locations within 60-180minutes. This quantitative, biopsy-wide, nanomechanical profile strongly correlates to the tissue's biological composition. Post-AFM this biopsy is analyzed by pathology. We sought to differentiate benign from cancerous lesions based on nanomechanical properties; then link the cancerous nanomechanical profiles prospectively to the clinical outcomes. Results: Our results demonstrate the first AFM based nanomechanical profiling to detect aggressive breast cancer subtypes using fresh tissue in a clinical setting. We have shown that nanomechanical profiles of human breast cancer biopsies display stiffness profiles distinct from surrounding normal tissue. Breast cancer subtypes were distinguishable by their nanomechanical properties only. We have discovered specific nanomechanical profiles of tumor subtypes likely to metastasize. When the primary tumor displayed the same soft nanomechanical profile as adjacent tissue, this was associated with positive nodal status. Conclusions: Our results demontrate nanomechanical profiling is a fast and sensitive method to stratify malignant biopsies into relevant subgroups in a clinical setting. Relative stiffness and distribution values provide a nanomechanical profile indicating cancer aggressiveness. This will help optimize specific cancer diagnosis, orientate therapy choice and support patient follow up.
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Rasskazova, E. "Latent personality profiles in mental illnesses: analysis of restructured clinical scales of MMPI-2." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 1 (May 15, 2019): 52–60. http://dx.doi.org/10.31363/2313-7053-2019-1-52-60.
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On a sample of 262 patients with mental illnesses based on restructured clinical scales of MMPI-2 six latent personality profiles were identified. A “suppressive” profile is characterized by a tendency toward self-presentation, suppression, and is more common with adaptation disorder and schizophrenia. The “normative” profile can be combined with aggressiveness, difficulties of behavior control and is typical for every second patient with addictions. The “psychopathized” profile is haracterized by a nonspecific increase in psychopathological complaints and is common in depressions. The “neurotic” profile is typical for patients with affective and schizotypal disorders. The “schizoid” profile is associated with signs of bizarre mantations, psychotic symptoms and fears, while the profile of decompensation reflects a general acute condition or responses invalidity.
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Giusca, Simona Eliza, Elena Corina Andriescu, Irina Draga Caruntu, and Delia Ciobanu. "Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?" Biomedicines 11, no. 1 (January 3, 2023): 116. http://dx.doi.org/10.3390/biomedicines11010116.
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Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to identify criteria that could predict increased aggressiveness. We analyzed 59 consecutive MTC cases. We focused on the relationships among clinicopathological characteristics, parameters of aggressiveness (extrathyroidal extension, lymphovascular invasion, and lymph node metastasis), and parameters for MTC grading. Statistically significant correlations were found for tumor size, lymphovascular invasion, and lymph node metastasis and tumor focality and lymph node metastasis. Our results showed, in tumors larger than 40 mm, odds ratios (ODs) of 13.695 and 6 for lymphovascular invasion and lymph node metastasis, respectively; in multifocal tumors, we registered an OD of 9.42 for lymph node metastasis. No significant correlation was found for the parameters of the MTC grading system when assessed individually and integrated by reporting low-grade and high-grade risk groups. Although our data indicate that lymphovascular invasion and lymph node metastasis remain significant markers for aggressiveness, studies on larger series of cases are mandatory to detect and validate new factors responsible for the variable course of MTC.
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Escalante, Hugo Jair, Esaú Villatoro-Tello, Sara E. Garza, A. Pastor López-Monroy, Manuel Montes-y-Gómez, and Luis Villaseñor-Pineda. "Early detection of deception and aggressiveness using profile-based representations." Expert Systems with Applications 89 (December 2017): 99–111. http://dx.doi.org/10.1016/j.eswa.2017.07.040.
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Boussaidi, Ahmed, and Mounira Sidhom Hamed. "The Impact of Governance Mechanisms on Tax Aggressiveness: Empirical Evidence from Tunisian Context." Journal of Asian Business Strategy 5, no. 1 (February 19, 2015): 1–12. http://dx.doi.org/10.18488/journal.1006/2015.5.1/1006.1.1.12.
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Research on the tax side occupied the stage center during the last decade. Several researchers have attempted to study the different effects of some options such as tax aggressiveness on firms and individuals. Overall, tax aggressiveness affects negatively the longevity of companies but what remains unanswered is by what specific means corporate governance decreases tax aggressiveness activities. In this paper, we examine the effect of some governance mechanisms on corporate tax aggressiveness. The study is based on the analysis of a sample of Tunisian listed firms over the 2006-2012 periods. Our regression results indicate that diversity in gender on corporate board, managerial and concentration ownership has significant effects on firms` tax aggressiveness activities. Board`s diversity and managerial ownership exhibit a positive association with the effective tax rate while increases in concentration ownership tend to affect it negatively. However, findings don`t show any significant effects of corporate board size and external auditor`s profile on the tax aggressiveness.
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Sobchik, L. N., B. A. Spasennikov, and S. V. Kulakova. "Criminological Aspects of Aggression." Psychology and Law 12, no. 1 (2022): 209–25. http://dx.doi.org/10.17759/psylaw.2022120116.
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The results of a retrospective study of groups of convicts with varying degrees of aggressive behavior show the possibilities of the Standardized Multifactorial Personality Research Method (SMIL, the Russian version of MMPI), the interpretive approach of which is based on the one created by L.N. Sobchik theory of leading trends in assessing the degree of aggressiveness corresponding to the severity of the committed act. The leading tendencies, according to the average profiles of SMIL, are determined: among "hooligans" impulsivity with weakly expressed aggressiveness and unformed self-control; the "robbers" have rigidity, readiness for illegal behavior; in "killers" the severity of aggressiveness (in the hyperthymic type, explosive features and properties of expansive-schizoid accentuation; in the hypersthenic type, exaltation, overestimated self-esteem, an outwardly blaming type of response; in persons with impulse pathology, a partial violation in the sexual sphere with preserved intelligence); for “corrupt officials”: the profile is in the corridor of normative dispersion, but self-esteem and ideas about their own material well-being are directly proportional; in minors, aggression acts as a hypercompensation of an insecure personality with pseudo-aggressive actions.
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Obminski, Zbigniew, Helena Mroczkowska, Marina Jagiello, and Artur Litwiniuk. "Sex-and sport related differences in the personality traits students in volleyball, basketball and judo athletes." Physical education of students 24, no. 6 (December 30, 2020): 304–11. http://dx.doi.org/10.15561/20755279.2020.0601.
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Background and Study Aim. Psychology is a very important field of knowledge in every area of human life, and personality and temperament have a large impact on the quality of human life, including mental and physical health, and indirectly on the results achieved in elite sport. The purpose of the study was to verify the assumption that there are differences in the psychological profile of professional sportsman students depending on the gender and type of sports discipline.
Material and methods. The research covered athletes of both sexes belonging to academic sports clubs practicing volleyball, basketball and judo. The size of each of the six groups was 24 people. Standardized psychological tests were used to determine the levels of selected personality and temperamental traits: trait anxiety, neuroticism, extraversion, briskness, perseveration, sensory sensitivity, emotional reactivity, endurance, activity, and six components of aggressiveness: physical aggressiveness, verbal aggressiveness, indirect aggressiveness, negativism, suspiciousness, resentment, irritability, overall and guilty sense. Two-way analysis of variance (sex * sport) was used to assess the differences between the groups.
Results. Women showed higher trait anxiety, extraversion, perseveration, emotional reactivity results and lower physical aggressiveness levels compared to men. Basketball practitioners had the lowest levels of aggressiveness components, and the highest levels of briskness.
Conclusions. The results suggest that the psychological profile of women participating in competitive sports may account for a higher emotional cost than men in terms of competition and failure. This fact should be taken into account by the coaches of female sports teams. The differences between sports may be due to the different structure of the task.
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Waro, Mochammad Choirul, and Alifiati Fitrikasari. "Profile of Schizophrenia Aggressiveness with the Risk of Suicide based on the Personality and Social Performance Score." Scientia Psychiatrica 2, no. 1 (January 3, 2021): 38–41. http://dx.doi.org/10.37275/scipsy.v2i1.27.
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A B S T R A C TIntroduction. The risk of schizophrenia for suicide is 10%, of which 10% -15% ofpeople with schizophrenia die of suicide at 20 years of follow-up. Aggressiveness is afactor to be watched out. Other factors are hallucinations, suicide, early-onset,history of schizophrenia, surveillance, age, gender, education, genetics, affect ofdepression. This study aimed to describe the sociodemographic profile,aggressiveness, hallucinations of suicide in schizophrenic patients. Methods. Thedesign of this study is descriptive research. The number of samples in this study was49 schizophrenic patients at risk of suicide. The risk of aggressiveness is measuredby the Personality and Social Performance Score. Results. Of the 49 patients, it wasfound that the proportion of male patients was 31 people (63.3%) and 18 women(36.7%). Aggressive behaviour based on PSP score was divided into modestaggressiveness of 22 people (44.9%), severe 20 people (40.8%), very severe two people(4.1%). Suicidal hallucinations were also found in 11 patients (22.4%). Conclusion.There are markedly aggressive behaviour and hallucinations of suicide in the majorityof schizophrenic patients.
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Diveeva, K. A. "Sociological Analysis of the Profile of Extremist." Sociology and Law, no. 3 (October 19, 2021): 40–44. http://dx.doi.org/10.35854/2219-6242-2021-3-40-44.
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The article is devoted to the discussion of the psychological and socio-demographic characteristics of the extremist's personality. The author of the article focuses on the relevance of studying the ideas about the image of an extremist in the public consciousness. The article presents the results of a study conducted in 2021 to identify the attitude of the population of the Krasnoyarsk district to the problems of extremism and radicalism. The results of the study showed that the dominant image of an extremist among the residents of the region is negative. The respondents attributed to the main features inherent in the personality of an extremist: aggressiveness, bitterness, cruelty, intolerance to people, hostility, lack of education, selfishness.
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Deslandes, Manon, Anne Fortin, and Suzanne Landry. "Audit committee characteristics and tax aggressiveness." Managerial Auditing Journal 35, no. 2 (December 11, 2019): 272–93. http://dx.doi.org/10.1108/maj-12-2018-2109.
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Purpose This study aims to analyze the relationship between a company’s use of aggressive tax planning and several audit committee members’ characteristics, namely, independence, expertise, diligence and gender diversity. Design/methodology/approach This paper is an empirical research using archival data from 289 Canadian listed companies for the 2011-2015 period. Findings The authors find that measures of expertise and diligence are significantly related to tax aggressiveness. Financial expertise and tenure on the audit committee play an important role in constraining tax aggressiveness, as does having a larger audit committee. Research limitations/implications One limitation – and an area for future research – is that the effects of the audit committee members’ relationships with managers of the firms were not investigated. Practical implications Knowledge of audit committee characteristics may send a signal to shareholders, investors and tax agencies regarding the company’s potential risk with respect to aggressive tax planning. The analysis provides useful insights for board governance committees when determining the profile of persons to nominate for board positions and committees. In discussing tax-risk management, the study may heighten audit committee members’ awareness of their role in this respect. Originality/value This study’s results indicate that even in a setting where incentives for firms to be tax-aggressive is low compared to high-tax rate countries, there is variability in firms’ tax aggressiveness. This situation allows us to find audit committee characteristics that are effective in decreasing tax aggressiveness.
Dissertations / Theses on the topic "Aggressiveness profile"
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Tuccitto, Alessandra. "pH regulatory molecules in the tumour microenvironment : modulators of aggressiveness and immune profile of human hepatocellular carcinoma." Thesis, Open University, 2018. http://oro.open.ac.uk/55985/.
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Background: Hepatocellular carcinoma (HCC) arises in an inflammatory, hypoxic/acidic microenvironment that favours tumour progression and fosters immunosuppression. Tumour cells survive this hostile environment by over-expressing pH regulatory molecules such as carbonic anhydrase (CA) IX, XII and V-ATPase complex, but the relevance of these molecules in HCC is poorly defined. Aim: The aim of this study was to dissect the relationships between pH regulatory molecules and the aggressive behaviour of malignant hepatocytes, and to evaluate how pH regulatory molecules influence the immune microenvironment of HCC. Methods: HCC, non-tumour and normal liver tissue samples were analysed by qRT-PCR for the expression of genes encoding the pH regulatory molecules (CAIX, CAXII and V-ATPase), of genes associated to epithelial-to-mesenchymal-transition (EMT) (TWIST, CDH1, VIM) and those encoding for HCC stem cell-associated markers (CD13, CD24, CD44, CD90, EpCAM, CD133, KRT19, OCT4, NANOG and SOX2). Selected HCC, non-tumour and normal liver tissue samples were evaluated by immunohistochemistry (IHC) to detect the presence and localization of CAIX, CAXII and VATPase and to assess the distribution of macrophages and T cells. Confocal microscopy and flow cytometry were implemented to assess the co-expression of selected markers. HCC cell lines, characterised for the expression of pH regulators, were tested for the sensitivity to the CAIX, CAXII, and V-ATPase specific inhibitors. The effects of V-ATPase specific drug were also studied ex vivo in primary human HCC tumour explants by qRT-PCR and by flow cytometry in HCC single cell suspensions obtained by the enzymatic digestion of HCC specimens. Results: Our mRNA analysis showed that the expression of CA9 was significantly correlated with the expression of the hypoxia-inducible factor 1α-related gene (HIF1A) and of the stem cell-associated markers CD24, CD133, EpCAM and KRT19. Moreover, mRNA for CA9 and for the different CA12 isoforms were associated with tumour grading, thus indicating their possible role in tumour malignancy. Applying a machine learning tool known as the ‘Adaptive Index Model’ the combined expression of different CA12 isoforms, CD209 and CDH1 defined a ‘signature’ classifying HCC patients in groups at different risk of recurrence, thus indicating a link between pH regulators, myeloid and EMT markers likely influencing HCC prognosis. IHC analysis indicated that HCC displays a complex expression pattern for the pH regulatory proteins. Both CAIX and CAXII were detected in transformed, but not in normal hepatocytes. CAIX protein had a focal distribution in the tumour, thus supporting its possible association with hypoxic and the most aggressive tumour area. Conversely, CAXII was homogeneously expressed by all tumour hepatocytes, but mainly retained in the endoplasmic reticulum (ER). The majority of HCC expressed V-ATPase which, importantly, was also present in immune infiltrating cells. This expression pattern qualified the CAIX, CAXII and V-ATPase as possible targetable molecules. Our in vitro data indicated that blockage of their enzymatic activities by specific drugs affected the viability of HCC cell lines in a dose dependent fashion, although with the CAXII specific inhibitor showing low efficacy, likely related to the preferential ER localization of CAXII molecules inside the HCC cells. Ex vivo experiments with HCC tissue explants and HCC cellular suspensions showed that inhibition of VATPase modulated the epithelial/mesenchymal features of HCC cells and the levels of pro- and anti-tumour cytokines expressed by M2 macrophages and T cells infiltrating HCC. Conclusions: Herein, our data demonstrated that the pH regulatory molecules, CAIX, CAXII and V-ATPase are over expressed in the HCC microenvironment and interfering with their pathways exerted anti-tumour activities, although these data also lead to the conclusion that more effective CAXII specific drugs should be designed. The results of this thesis also suggest that pH regulatory molecules might have a role in HCC aggressiveness and prognosis. Importantly, one of these pH regulators, namely V-ATPase complex, influences the mesenchymal features of tumour cells and the immunosuppressive tumour microenvironment (TME). Interfering with tumour metabolism is an emerging strategy for treating cancers that are resistant to standard therapies. Thus, targeting the unique crosstalk between tumour cells and the microenvironment, played by the pH regulatory molecules, can be considered as a new option for HCC treatment and the blockage of the V-ATPase complex might represent a multi-task strategy for the treatment of HCC patients.
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Morais, David. "Les déterminants des phases épidémiques précoces de la septoriose du blé (Zymoseptoria tritici) : quantité, efficacité et origine de l'inoculum primaire." Electronic Thesis or Diss., Paris, AgroParisTech, 2015. http://www.theses.fr/2015AGPT0021.
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Les maladies foliaires fongiques sont une contrainte majeure des systèmes céréaliers. Elles constituent par ailleurs de précieux modèles d'étude pour comprendre comment commence une épidémie, questionnement récurrent en épidémiologie végétale. Dans cette thèse ont été étudiés trois des principaux déterminants des phases précoces des épidémies de septoriose du blé causée par Zymoseptoria tritici : quantité, efficacité et origine de l'inoculum primaire. L'étude a porté sur deux épidémies successives dans deux parcelles de blé proches l’une de l’autre au sein d'un dispositif pluriannuel (2011-2013 ; Grignon, France). La première parcelle, caractérisée par l'absence de résidus, était exposée à des sources distantes d'inoculum primaire, et la seconde, en monoculture de blé depuis plusieurs années, présentait une quantité importante de résidus contaminés agissant comme source locale d'inoculum primaire. Dans la première partie de la thèse, la capture d’ascospores à l’aide d’un piège volumétrique couplé à une quantification de l'ADN par qPCR a permis de quantifier l'inoculum primaire présent dans l'air au-dessus des parcelles pendant les phases épidémiques précoces. Les limites de détection et de quantification ont été déterminées, discutées et utilisées afin d'estimer de faibles quantités d’ascospores. Ni la présence locale de résidus contaminés ni la quantité d’inoculum au-dessus des parcelles n'ont été corrélées avec la précocité des deux épidémies. Dans la seconde partie, la pathogénicité des ascospores et des pycnidiospores de Z. tritici a été estimée sur plante adulte et comparée. La période de latence consécutive à une infection par ascospore a été plus longue de 60 degrés-jour qu’après une infection par une pycnidiospore. Dans la troisième partie de la thèse, qui visait à identifier l'origine de l'inoculum primaire, deux stratégies ont été adoptées. La première stratégie a consisté à rechercher des changements dans la structure génétique de différentes sous-populations collectées dans les deux parcelles sur une période de trois années en utilisant des marqueurs neutres (SSR). Aucune structure n'a été identifiée, mais de légères différenciations chez certaines sous-populations, cohérentes avec le contexte épidémiologique (nature du cycle de reproduction dont elles découlent, période épidémique, intensité de maladie), ont été mises en évidence. Ces résultats n'ont toutefois pas permis de déterminer l'origine de l'inoculum primaire puisqu'aucune différence entre les sous-populations résidantes (locales) et immigrantes (distantes), ni de discontinuité génétique entre sous-populations de fin (saison n) et de début d'épidémie (saison n+1), n'a été mise en évidence. La seconde stratégie a consisté à comparer le profil d'agressivité (capacité de sporulation et période de latence) d’une population de Z. tritici collectée en début d’épidémie dans la parcelle en monoculture de blé, à celui d'une population résidante (ascospores issues des résidus présents dans la parcelle) et d'une population immigrante (lésions provoquées par des ascospores d'origine distante). Le profil de la population testée, plus proche de celui de la population résidante, a suggéré que l'épidémie avait été déclenchée majoritairement par un inoculum primaire d’origine locale. Il ressort de cette étude de cas qu’une gestion quantitative (réduction) de l'inoculum primaire serait probablement très peu efficace, tandis que sa gestion qualitative, tenant compte de l'adaptation différentielle de populations pathogènes à leurs hôtes, mériterait d’être intégrée dans des stratégies de protection (alternance de variétés dans le temps). Pour finir, la définition du début et de la fin d'une épidémie a été discutée, selon que l’on se place à une échelle annuelle (absence de l’hôte comme critère de début/fin) ou pluriannuelle (discontinuité de pression pathogène comme critère de début/fin, indépendamment de l’absence de l'hôte)Fungal foliar diseases are a major constraint to cereal production systems. They constitute relevant models to elucidate how an epidemic begins, which is a recurrent question in plant disease epidemiology. In this thesis three of the main components of the early stages of the epidemics of septoria tritici blotch, a wheat disease caused by Zymoseptoria tritici, were studied: the quantity, the efficiency and the origin of primary inoculum. The study focused on epidemics occurring over the 2011-2013 cultural seasons in two wheat plots located close to each other in Grignon (France). The first plot, characterized by the absence of debris, was exposed to distant sources of primary inoculum, while the second plot, grown in wheat for several years, had a large amount of contaminated debris acting as a local source of primary inoculum. In the first part of the thesis, ascospore trapping using a volumetric spore trap combined with DNA quantification by qPCR allowed to quantify the inoculums present in the air above the wheat plots during the early stages of the epidemics. The limits of detection and quantification were determined, discussed and used to estimate small amounts of ascospores. Neither the local presence of contaminated debris nor the quantity of inoculum above the plots was correlated with the earliness of the epidemics. In the second part, the pathogenicity of Z. tritici ascospores and pycnidiospores was estimated on adult plants. The latent period following infections by ascospores was 60 degree-days longer than following infection by pycnidiospores. In the third part of the thesis, which aimed to identify the source of primary inoculum, two strategies were developed. The first strategy investigated changes in the genetic structure of different subpopulations collected from both wheat plots over a period of three years using neutral markers (SSR). No structure was identified, but slight differentiations in some subpopulations, consistent with the epidemiological context (nature of the reproduction cycle from which they derived, epidemic period, disease intensity) were highlighted. These results, however, did not allow to determine the origin of the primary inoculum because no difference between resident (local) and immigrant (distant) subpopulations, or a genetic discontinuity between subpopulations from the end (season n) and the beginning of epidemics (season n + 1), were identified. The second strategy compared the aggressiveness profile (sporulation capacity and latent period) of a Z. tritici population collected at the beginning of an epidemic in the monoculture wheat plot and of a resident population (ascospores ejected from debris present in the plot) and to an immigrant population (leaf lesions caused by ascospores of distant origin). The profile of the tested population, closer to that of the resident population, suggested that the epidemic was mainly initiated by primary inoculum of local origin. This case study showed that a quantitative management (reduction) of the primary inoculum would be probably inefficient, while its qualitative management, taking into account the differential adaptation of pathogen populations to their hosts, deserves to be taken into account in crop protection strategies (alternating wheat cultivars in time). Finally, the definition of the beginning and the end of an epidemic was discussed, depending if we consider an annual scale (absence of the host as a beginning or end criterion) or a multiannual scale (pathogen pressure discontinuity as the beginning or end criterion, regardless of the absence of the host)
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González, Alcalá Cristina. "Bureaucrats: The Exploration and Development of Profiles of Their Communicator Styles and Predispositions." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1589802375410337.
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Mallet, Jasmina. "Marqueurs neurodéveloppementaux, cognition et facteurs environnementaux précoces et tardifs dans le phénotype psychotique des pathologies mentales Heavy cannabis use prior psychosis in schizophrenia : clinical, cognitive and neurological evidences for a new endophenotype? Etude et apport de la latéralité comme marqueur neurodéveloppemental dans les troubles schizophréniques et bipolaires Cigarette smoking and schizophrenia : a specific clinical and therapeutic profile? Results from the Face-Schizophrenia cohort Tobacco smoking is associated with antipsychotic medication, physical aggressiveness and alcohol use disorder in schizophrenia : results from the Face-SZ national cohort Tabagisme et schizophrénie, impact sur la cognition Tobacco smoking and psychotic-like experiences in a general population sample Poster congrès français de psychiatrie 2018 : Expériences psychotiques chez 50 patients adolescents hospitalisés pour la 1ère fois : approche trans-diagnostique et prospective avec la PQ16." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2403&f=17360.
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Les maladies mentales représentent un ensemble catégoriel très hétérogène, même au sein d’une entité nosographique. L’approche multifactorielle rend compte de l’hétérogénéité clinique des troubles mentaux et du continuum entre certaines dimensions cliniques, voire entre le normal et le pathologique. Parmi ces dimensions, le phénotype psychotique constitue une dimension essentielle du trouble schizophrénique. L’approche dimensionnelle permet d’envisager la recherche d’expériences psychotiques dans la plupart des troubles mentaux ainsi qu’en population générale. Nous faisons l’hypothèse générale que certains troubles psychiatriques avec symptômes psychotiques pourraient être la résultante de l’interaction entre certains facteurs environnementaux précoces (traumatismes obstétricaux par exemple) et tardifs (consommation de toxiques, traumatismes) et le neurodéveloppement de l’individu. Un travail initial a été de rappeler les concepts de vulnérabilité en psychiatrie, et de prendre l’exemple du trouble schizophrénique pour réaliser une revue de la littérature sur les facteurs de risque en fonction de leur interaction précoce ou tardive avec le neurodéveloppement. Ensuite, dans le premier axe de recherche de la thèse, nous évaluons certains marqueurs neurodéveloppementaux précoces (signes neurologiques mineurs, latéralité, cognition). Notre premier travail, concerne la caractérisation clinique, neurologique et cognitive de 64 patients souffrant de trouble schizophrénique, en fonction de leur consommation de cannabis ou pas avant le début des troubles. Il apporte des éléments en faveur d’une charge neurodéveloppementale moins lourde chez les patients ayant consommé du cannabis, et de l’impact potentiel de cette substance chez des sujets vulnérables. Notre second travail, préliminaire, concerne l’impact clinique et cognitif de la latéralité chez les patients souffrant de schizophrénie (n=667) et de trouble bipolaire (n=2445). Nous apportons des arguments pour un poids neurodéveloppemental (mesuré avec cet indice) plus important dans la schizophrénie. Notre deuxième axe de recherche se concentre sur le tabagisme comme facteur environnemental tardif dans le trouble schizophrénique et le phénotype psychotique. Nous montrons dans deux travaux sur la cohorte FACE-SZ (n=361 ; n=474), que ces patients consomment presque deux fois plus qu’en population générale et qu’ils pourraient représenter un sous-groupe présentant des caractéristiques spécifiques d’un point de vue socio-démographique, clinique et thérapeutique. Dans un troisième travail préliminaire, nous comparons les fonctions cognitives de ces patients (n=785) et montrons que l’hypothèse d’automédication ne peut pas rendre compte à elle seule, de la forte prévalence du tabagisme chez ces patients. Dans un quatrième travail, nous étudions l’impact du tabagisme sur le phénotype psychotique dans une approche dimensionnelle, et montrons une association entre le tabagisme et certaines expériences de type psychotique dans un échantillon représentatif de la population générale américaine (NESARC, n=34653). Enfin dans un dernier axe de recherche nous nous intéressons au phénotype psychotique dans une population d’adolescents et jeunes adultes hospitalisés pour un premier épisode psychiatrique (n=50). Dans une étude préliminaire, nous montrons une forte prévalence des expériences de type psychotique chez ces jeunes adultes, quel que soit le diagnostic posé six mois à postériori, soulignant le caractère trans-nosographique du phénotype psychotique lors de l’émergence des troubles. L’ensemble de ce travail reflète l’hétérogénéité clinique des maladies mentales et l’importance de l’approche dimensionnelle et trajectorielle pour identifier des facteurs de risque (ou de protection). Les enjeux sont une meilleure compréhension étiopathogénique, des perspectives de prévention, et une prise en charge personnalisée des patientsMental diseases represent a very heterogeneous categorical group, even within a given nosographic entity. Multifactorial approaches allow accounting for the clinical heterogeneity of mental disorders, the continuum between certain clinical dimensions, and even between the normal and the pathological. Among such dimensions, the psychotic phenotype constitutes an essential dimension of schizophrenic disorder. The dimensional approach allows for the search of psychotic experiences in most mental disorders as well as in the general population. We make the general hypothesis that certain psychiatric disorders with psychotic symptoms could be the result of the interaction between early- (obstetric traumas for example) and late- environmental factors (toxics, traumatisms) and the neurodevelopment of the individual. The initial step in this thesis work was to better define the concepts of vulnerability in psychiatry, and, based on the example of schizophrenia, to conduct a review of the literature on risk factors according to their early or late interaction with neurodevelopment. Subsequently, the first axis of research of the present thesis was to evaluate early neurodevelopmental markers (neurological soft signs, laterality, cognition). Our first work concerned the clinical, neurological and cognitive characterization of 64 patients suffering from schizophrenia, according to their cannabis use (or not) prior to psychosis. It provided evidence for a lower burden of neurodevelopment in cannabis users, and the potential impact of this substance on vulnerable individuals. Our second work concerns the clinical and cognitive impact of lateralization in patients with schizophrenia (n = 667) and bipolar disorder (n = 2445). We bring arguments for a neurodevelopmental weight (measured with this lateralization index) that is more important in schizophrenia. Our second axis of research focused on tobacco smoking as a late environmental factor in schizophrenia and psychotic phenotype. We showed in two studies on the FACE-SZ cohort (n = 361, n = 474) that SZ patients consumed almost twice as much as the general population and that they could represent a SZ subgroup with specific socio-demographic and clinical characteristics. In a third study, we compare the cognitive functions of these patients (n = 785) and show that the self-medication hypothesis alone cannot account for the high prevalence of their smoking. In a fourth work, we studied the impact of smoking on the psychotic phenotype with a dimensional approach, and showed an association between smoking and certain psychotic-type experiences in a representative sample of the US general population (NESARC, n = 34653). Finally, in a last line of research, we evaluated the psychotic phenotype in a population of adolescents and young adults hospitalized for a first psychiatric episode (n = 50). In a preliminary study, we show a high prevalence of psychotic-like experiences in these young adults, regardless of the diagnosis made six months afterwards, highlighting the trans-nosographic character of the psychotic phenotype during the emergence of different mental disorders. Overall, the present thesis underscores the clinical heterogeneity of mental illnesses and the importance of dimensional and trajectory approaches in identifying risk (or protective) factors, towards a better etiopathogenic understanding, better prevention opportunities, and a personalized patient care
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Du, Preez Frederika Elizabeth. "Ondersoek na die persoonlikheidsprofiel van slagoffers van afknouery." Diss., 2007. http://hdl.handle.net/10500/2083.
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Text in AfrikaansThe goal of the research is to explore the personality profile of aggressive victims of bullying in a special school. Qualitative, applied research of an explorative and descriptive nature was followed. In order to address the problem, namely that the personality profile of children can lead to aggressive victims, the researcher undertook a literature study to describe bullying in middle childhood with the focus on aggressive victims, the Five Factor Model of Personality, bullying in special schools and organismic selfregulation within Gestalt therapy. The researcher's knowledge of the Five Factor Model of Personality enabled her to compile the interview schedules for the semi-structured interviews. Purposeful sampling was conducted to identify respondents for the interviews. The interviews were conducted with four aggressive victims of bullying, their parents, as well as their class teachers. During the analysis of data, themes were identified. These themes were verified with literature and recommendations were made.
Social work
M.Diac.(Play therapy)
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Cardoso, José Emanuel Quintela. "Personalidade e agressividade : um estudo em militares de protecção e socorro." Master's thesis, 2010. http://hdl.handle.net/10437/1255.
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Orientação: João Pedro OliveiraA protecção e socorro é das missões mais recentes na instituição militar em Portugal, nomeadamente a intervenção em catástrofes. As características têm um papel decisivo, pois podem condicionar de forma determinante o sucesso da missão. O discernimento do indivíduo é imperativo nas situações, não pode haver erros, pois os custos humanos e económicos são demasiado elevados. Foi estudada uma amostra de 535 militares oportugueses de uma força de elite helitransportada que actua em catástrofes, em que a média de idades é de 28 anos (DP=4,4), tendo o militar mais novo 20 anos e o mais velho 49 anos. O escalão etário mais representado é o escalão dos 26-30 anos que compreende 52,7% desta força militar operacional. Para esta investigação utilizámos como medidas de avaliação o Inventário de Personalidade Neo revisto, NEOPI-R (Costa & McCrae 1992), o Questionário de Agressividade, AQ (Buss & Perry, 1992)e a Escala de Desejabilidade Social de Paulhus, PDS (Paulhus, 1998) para aceder à relação entre personalidade, agressividade e desejabilidade social em militares de protecção e socorro. Conclui-se que os militares de protecção e socorro demonstram valores elevados de conscienciosidade e valores mais baixos ao nível do domínio do neuroticismo. Demonstraram resultados mais elevados na dimensão Gestão da imagem e mais baixos na dimensão de Auto apresentação favorável. Apresentam ainda níveis de agressividade física bastante elevados e níveis de irritabilidade mais baixos.
Rescue and protection is one of the latest missions in the Military Corps in Portugal, namely the Disaster Intervention. It depends directly on individual characteristics such as personality and how the military deal with extreme and tension situations. These characteristics have a decisive role, as they contribute to the success of decisive missions. The discernment of the individual is imperative in situations where there can be mistakes, because the human and economic costs are too high. The studied sample consisted of 535 soldiers of the military Portuguese Protection and Rescue, an elite force heliborne, where the average age is 28 years (DP=4,4 years), having the younger military 20 years and the oldest 49 years. The age group most represented is the level 26-30 years comprising 52.7% of this military operational force. In order to make this investigation we used the following measures : the Neo Personality Inventory Revised, NEOPI-R (costa & McCrae, 1992), the Agression Questionnaire, AQ (Buss & Perry, 1992), and the Paulhus Deception Scale, PDS (Paulhus, 1998) to access the relationship between personality, aggressiveness and social desirability in Rescue and Protection Military. It is concluded that Rescue and Protection military show high values of conscientiousness and lower values of neuroticism. They also show higher scores on the impression management and lower scores on the Self-Deceptive Enhancement dimension. Subjects also present high levels of physical aggression and lower levels of anger.
Books on the topic "Aggressiveness profile"
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E, Brown Marjorie, Cochran Donald, Doherty Dianne, and Massachusetts. Office of the Commissioner of Probation., eds. Young adolescent batterers: A profile of restraining order defendants in Massachusetts. [Boston, MA (1 Ashburton Pl., Boston 02108)]: Massachusetts Trial Court, Office of the Commissioner of Probation, 1994.
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Tessier, Odile. Profil de comportement et habiletés interpersonnelles chez des garçons agressifs et non agressifs durant l'enfance et l'adolescence: Rapport de recherche au CQRS, subvention RS-2237 093. Sherbrooke [Québec]: O. Tessier, 1997.
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Sherman, Mark E., Melissa A. Troester, Katherine A. Hoadley, and William F. Anderson. Morphological and Molecular Classification of Human Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0003.
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Accurate and reproducible classification of tumors is essential for clinical management, cancer surveillance, and studies of pathogenesis and etiology. Tumor classification has historically been based on the primary anatomic site or organ in which the tumor occurs and on its morphologic and histologic phenotype. While pathologic criteria are useful in predicting the average behavior of a group of tumors, histopathology alone cannot accurately predict the prognosis and treatment response of individual cancers. Traditional measures such as tumor stage and grade do not take into account molecular events that influence tumor aggressiveness or changes in the tumor composition during treatment. This chapter provides a primer on approaches that use pathology and molecular biology to classify and subclassify cancers. It describes the features of carcinomas, sarcomas, and malignant neoplasms of the immune system and blood, as well as various high-throughput genomic platforms that characterize the molecular profile of tumors.
Book chapters on the topic "Aggressiveness profile"
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Rodrigues Paula, Claudete, Bianca Silva Navarro, Mário Mendes Bonci, and Diana Costa Nascimento. "Importance of Yeasts in Oral Canine Mucosa." In Canine Genetics, Health and Medicine. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95905.
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Dentistry science is a new specialty in veterinary medicine that has been growing in recent years, accompanied by the development of professionals who seek to improve the quality of life of pets. Cases related to problems in the oral cavity have gained significant importance in the medical clinic of professionals who treat small animals. Due to lack of professional knowledge or due to animal behavioral problems, such as aggressiveness, the anamnesis of the oral cavity is not performed most of the time, which ends up delaying the diagnosis of the pathology. In addition, an animal with a problem in the oral cavity may take years to show signs of the disease. In general, animals have an oral microbiota composed of various species of fungi, which, under specific conditions, can change from saprophytes to pathogens, compromising their health. Thus, the pre-knowledge of potentially pathogenic yeasts belonging to oral microbiota of dogs and their susceptibility profile compared to the main drugs used in antifungal therapy, is of fundamental importance as it ensures a clinical auxiliary support for the diagnosis and treatment of most diseases of the oral cavity.
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Centonze, Giorgia, Jennifer Chapelle, Costanza Angelini, Dora Natalini, Davide Cangelosi, Vincenzo Salemme, Alessandro Morellato, Emilia Turco, and Paola Defilippi. "The Scaffold Protein p140Cap as a Molecular Hub for Limiting Cancer Progression: A New Paradigm in Neuroblastoma." In Pheochromocytoma, Paraganglioma and Neuroblastoma. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96383.
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Neuroblastoma, the most common extra-cranial pediatric solid tumor, is responsible for 9–15% of all pediatric cancer deaths. Its intrinsic heterogeneity makes it difficult to successfully treat, resulting in overall survival of 50% for half of the patients. Here we analyze the role in neuroblastoma of the adaptor protein p140Cap, encoded by the SRCIN1 gene. RNA-Seq profiles of a large cohort of neuroblastoma patients show that SRCIN1 mRNA levels are an independent risk factor inversely correlated to disease aggressiveness. In high-risk patients, SRCIN1 was frequently altered by hemizygous deletion, copy-neutral loss of heterozygosity, or disruption. Functional assays demonstrated that p140Cap is causal in dampening both Src and Jak2 kinase activation and STAT3 phosphorylation. Moreover, p140Cap expression decreases in vitro migration and anchorage-independent cell growth, and impairs in vivo tumor progression, in terms of tumor volume and number of spontaneous lung metastasis. p140Cap also contributes to an increased sensitivity of neuroblastoma cells to chemotherapy drugs and to the combined usage of doxorubicin and etoposide with Src inhibitors. Overall, we provide the first evidence that SRCIN1/p140Cap is a new independent prognostic marker for patient outcome and treatment, with a causal role in curbing the aggressiveness of neuroblastoma. We highlight the potential clinical impact of SRCIN1/p140Cap expression in neuroblastoma tumors, in terms of reducing cytotoxic effects of chemotherapy, one of the main issues for pediatric tumor treatment.
Conference papers on the topic "Aggressiveness profile"
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Lyles, Dustin, Cameron Devers, Warren Dyer, and Shawn Lyles. "Innovative Approach to Maximizing Completion Drill Bit Longevity." In SPE Annual Technical Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210203-ms.
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Abstract For almost a decade, the predominant completion drill-out bits utilized to drill composite frac plugs were roller-cone (RC) bits incorporating "hybrid" cutting structures. RC hybrid cutting structures consist of various layouts incorporating a combination of milled teeth (MT) and tungsten carbide insert (TCI) cutting elements that exhibit known trade-offs regarding longevity and performance. The objective of this paper is to illustrate how practicing engineers can, and should, question status quo to overcome traditional design/performance limiters. Extensive analysis of hybrid RC dull bits and performance data was conducted with the goal to advance RC completion drill bit longevity and performance while reducing non-productive time (NPT). Through quantifying and classifying cutting structure damage across 30 RC hybrid drill bits, data collected clearly illustrated which portions of the bit profile and cutting elements were sustaining the most damage. The data indicated commonly accepted hybrid RC designs display an inherent weakness that would require questioning common beliefs about completion RC bit design and manufacturing methodologies. A new bit design was developed and extensively field tested. The results of the dull bit evaluation indicated the MT are inherently less robust and result in more performance limiting cutting structure damage. The MT have been utilized as a standard due to industry acceptance, manufacturing limitations associated with implementing the more robust TCI's in all portions of the bit profile and perceived benefits with MT geometry. Implementing full TCI coverage to mitigate cutting structure damage required rethinking longstanding manufacturing methods and cutting element selection that have been accepted as industry standards. Changes in manufacturing methodology required increasing surface hardness of the cone face around TCI's to avoid loss due to interaction with slip debris and/or weakened TCI retention due to erosion. This change required a substantial and challenging shift in heat-treating methods and manufacturing workflow. Further changes were made to the TCI geometries in the new design to ensure the aggressiveness needed to fail soft composite plug materials into small debris sizes was equivalent or better than the MT cutting elements. The manufacturing, material and geometric changes resulted in a solution that contradicted previous trade-off understandings regarding completion drill bits by simultaneously improving durability and aggressiveness. The work exemplifies the importance for practicing engineers continuously to question status quo in pursuit of continuous improvement even when faced with longstanding beliefs and/or methodologies. Furthermore, the findings from the project give insight into completion drill-out trends and opportunities to reduce NPT and improve efficiency.
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Silva, Gabriela Calado, Denise Sobral Viana, Cecilia Souza Avila Pessoa, and Erich Roberto Santos da Costa Filho. "DESCRIPTIVE EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH HER2-POSITIVE METASTATIC BREAST CANCER SUBMITTED TO PERTUZUMAB AND TRASTUZUMAB AT THE CANCER HOSPITAL OF PERNAMBUCO." In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1024.
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Introduction: HER2-positive breast cancer is characterized by a hyperexpression or gene amplification of human epidermal growth factor receptor 2, a tyrosine kinase membrane receptor that has a profile with major aggressiveness and worse prognosis among all molecular subtypes. The metastatic pattern of this disease is one of the greatest challenges in mastology and requires an urgency and effective therapeutics to control this disease. Advances in therapy have allowed more specific treatments for anti-HER2 treatment that allowed improvement in the overall survival and disease-free survival of patients. Double-block therapy, performed by using Trastuzumabe and Pertuzumabe, is the first-line treatment for metastatic HER2-positive breast cancer. This kind of therapy was initially adopted effectively by SUS in 2019. Therefore, it is advisable to consider the use of this therapy at the Cancer Hospital of Pernambuco (HCP) to analyze the current results in patients and assess the local results. Objective: The goal of this study was to understand the epidemiological profile of patients with HER2-positive metastatic breast cancer treated at the HCP and submitted to double-block therapy with Trastuzumab and Pertuzumab, analyzing progression-free survival and overall survival. Methods: This is a retrospective descriptive study conducted in November 2021. Relevant aspects of treatment, analysis of disease-free survival, and overall survival were analyzed in the medical records of patients with metastatic HER2-positive breast cancer who used Trastuzumab and Pertuzumab. The survey of the analyzed data was carried out by completing a specific form created by the researcher especially for this study. Anonymity and clarity of the information were ensured. Results: From 124 selected medical records, this study selected 78 patients with metastatic HER2 breast cancer, with a mean age of 50.4 years; 62.34% had positive hormone receptors and 44.87% had metastasis de novo. About 36% of patients had been using double-block for up to 6 months, which made it difficult to assess the behavior of the disease from medical examinations and images, given the short time; but it was found that of all patients, 15.4% have disease stability, 32.1% had regression, and 28.2% had disease progression. There was a median of 12 months for disease progression, but with a median of 11 months of use of double-block therapy with Trastuzumab and Pertuzumab. As for the overall survival, it is estimated, based on statistical data from the current sample, that an accumulated probability of death of up to 16.7% in up to 5 years. Women older than 60 years and those who had disease progression had a higher risk of death. Conclusion: This study evaluated metastatic HER2-positive breast cancer as a particular behavior tumor. The patients selected from the HCP submitted to the use of Trastuzumab and Pertuzumab in the metastatic scenario have a follow-up time still recent, which causes incipient data for the evaluation of specific outcomes that depend on the temporal component. Follow-up and updates of the analysis of outcomes are suggested, in the near future, to enrich the treatments proposed for the target population. Ethical aspect: This study was conducted strictly based on the Resolutions 510/16 and 416/12 of the Health National Council and was only conducted after HCP Research Ethics Committee approval.
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Nohmi, Motohiko, Naoya Ochiai, Yuka Iga, and Toshiaki Ikohagi. "A Detailed Observation of Hydrofoil Cavitation and a Proposal for Improving Cavitation Model." In ASME 2010 3rd Joint US-European Fluids Engineering Summer Meeting collocated with 8th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30435.
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Cavitation of a hydrofoil is observed in detail by using a high speed video camera. A paint removal test is also carried out in order to evaluate cavitation aggressiveness for erosion. 2D hydrofoil profile is Clark Y 11.7% and its angle of attack is seven degrees. Cavitation number is σ = 1.08. The experimental results are compared with cavitation CFD. Numerous features of unsteady cavitation are observed such as cyclic fluctuation of the sheet cavity, existence of the glassy cones on a sheet cavity, generation of the cloud cavitation from the sheet cavity and the isolated bubbles traveling over the suction surface of the blade. The isolated traveling bubbles and their collapses are thought to be one of the main causes of the severe paint removals. The isolated traveling bubbles are derived from the flowing cavitation nucleus or from abrupt onset at the leading edge of the blade. For computing these complicated phenomena, combination of grid scale bubbles (GSB) and sub grid scale bubble model (SGSB) are proposed. GSB shall be computed by using the computational scheme for the free surface with phase change model. SGSB can be computed with conventional cavitation model. The breakup of GSB generates SGSB, and the coalescence of SGSB makes GSB. Upper limit of void fraction of SGSB is estimated in the range of five or ten percent from the simple speculation of the structure of packed spheres. The two types of cavitation bubble inception model are also discussed based on the generation of the isolated bubbles observed in the experiments. To verify the proposed concepts of cavitation model, a traveling air bubble over a hydrofoil is computed by using the free surface flow scheme of Volume of Fluid (VOF) approach. Cavitation on the hydrofoil is also computed by VOF approach with boiling model concerning the heat transfer. Both the computed results show qualitatively similar characteristics of the bubble dynamics to those in experimental results.
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Liu, Yongjun, Jinsong Li, Dong Lin, Jiacai Sun, Lei Luo, Guiyang Chen, Peng Li, et al. "Engineered Bit Design with New Cutter Technology Improved Drilling Efficiency in Abrasive Sandstone in China Ordos Basin." In Gas & Oil Technology Showcase and Conference. SPE, 2023. http://dx.doi.org/10.2118/214139-ms.
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Abstract Dual lateral horizontal wells were drilled for China Changbei tight gas development in Ordos basin. The horizontal 8 ½" hole section is the most challenge part for efficient well construction due to the hardness and abrasiveness of the consolidated sandstone rocks. Optimized drilling performance requires the matching of appropriate drill bit technology to an application for the formation to be drilled, which can be an engineering challenge. Various types of drill bits, including TCI, PDC and Hybrid type bits are used in Changbei for continuous performance improvement. The 8 ½" hole section consists of hard and abrasive sandstone, interbedded claystone, and conglomerates. Most drill bits suffered short runs due to severe wear in the outer region of the bit including Gauge and Shoulder area, even lost cones for TCI and Hybrid bits. With collaborations from operators and bit vendors, based on dull review and data analysis, a new type of PDC bit was designed with advanced cutter technology. The new design was developed to increase ROP and run length, avoiding unnecessary trips in the challenging formations and improved the drilling efficiency. The new designed PDC bit adopted short profile design, reversed circle cutter placement pattern, balanced the aggressiveness and durability with backup cutters and DOC control. PDC cutters was used for passive gauge protection to overcome the wear out due to formation abrasion. The field trials were very successful. The new designed PDC bit improved 30% on ROP and 10% on footage per bit run than offset Hybrid bits. Moreover, the new designed PDC bit eliminated lost cone risks of TCI and Hybrid bits, which was happened a couple of times in Changbei and caused tremendous NPTs for fishing and sidetracks. This article will describe the bit performance improvement journey of Changbei tight gas field. Even with a long period of time staying on plateau, step changes still possible with new technology deployment and continuous improvement mindset.
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Velazquez, Antonio, and R. Andrew Swartz. "Operational Risk Assessment of Wind Turbine Structures Using Probabilistic Analysis of Aerodynamically Induced Vibrations." In ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2011. http://dx.doi.org/10.1115/smasis2011-5100.
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The study of efficiency and safety for wind turbine structures under variable operating conditions is increasingly important for wind turbine design. Optimum aerodynamic performance of a wind turbine demands that serviceability effects and ultimate strength loads remain under safety design limits. From the perspective of wind turbine efficiency, variations in wind speed causes bluffing effects and vortex shedding that lead to vibration intensities in the longitudinal and transversal direction that can negatively impact aerodynamic performance of the turbine. From the perspective of wind turbine safety, variations in loading may lead to transient internal loads that threaten the safety of the structure. Inertial effects and asynchronous delays on rotational-force transmission may generate similar hazards. Monitoring and controlling displacement limits and load demands at critical tower locations can improve the efficiency of wind power generation, not to mention the structural performance of the turbine from both a strength and serviceability point of view. In this study, a probabilistic monitoring approach is developed to measure the response of the combined tower/nacelle/blade system to stochastic loading, estimate peak demand, and compare that demand to building code-derived estimates of structural resistance. Risk assessment is performed for the effects of along and across-wind forces in a framework of quantitative risk analysis with the goal of developing a near real-time estimate of structural risk that may be used to monitor safety and serviceability of the structure as well as regulate the aggressiveness of the controller that commands the blade angle of attack. To accomplish this goal, a numerical simulation of the aerodynamic performance of a wind turbine (including blades, the nacelle and the tower) is analyzed to study the interaction between the structural system and incoming flow. A model based on distributed-stationary random wind load profile for the combined along-wind and across-wind responses is implemented in Matlab to simulate full aero-elastic dynamic analysis to simulate tower with nacelle, hub, rotor and tower substructures. Self-weight, rotational, and axial effects of the blades, as well as lateral resistance of substructure elements are incorporated in the finite element model, including vortex-shedding effects on the wake zone. Reliability on the numerical solution is inspected on the tower structure by comparing the numerical solution with established experimental-analytical procedures.
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Sato, Takashi, Eri Arai, Takashi Kohno, Koji Tsuta, Shun-ichi Watanabe, Kenzo Soejima, Tomoko Betsuyaku, and Yae Kanai. "Abstract 5364: DNA methylation profiles at precancerous stage cluster lung adenocarcinomas into subclusters associated with carcinogenetic pathway, clinicopathological aggressiveness and patient outcome." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5364.
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Yamanoi, Kazuhiro, Eri Arai, Yoriko Takahashi, Sayaka Miyata, Ryoji Kushima, Hitoshi Katai, Michiie Sakamoto, and Yae Kanai. "Abstract 1370: Epigenetic clustering of gastric carcinoma based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1370.
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