Relevant bibliographies by topics / Agentic Regulation

Academic literature on the topic 'Agentic Regulation'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Agentic Regulation"

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Zielińska, Aleksandra, Izabela Lebuda, Dorota M. Jankowska, and Maciej Karwowski. "Self-Regulation in Creative Learning: Agentic Perspective." Creativity. Theories – Research - Applications 8, no. 1 (June 1, 2021): 52–71. http://dx.doi.org/10.2478/ctra-2021-0005.

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Abstract Creativity is agentic, and so is learning. People create and learn new things most effectively when they are convinced that they can respond appropriately to the task (creative confidence) and value the activity at hand. This investigation explores the role of the relatively understudied aspect of creative agency: self-regulatory strategies. In a longitudinal study, we tested whether self-regulation strategies, previously found to be essential drivers of academic achievement and learning in general (rehearsal, elaboration, critical thinking, and metacognition), might also support creativity in learning. Specifically, we tested sequential mediation, where creative confidence and self-regulation longitudinally mediated the relationship between creative potential (divergent thinking) and effective application of creative skills to solve problems embedded in school subjects. Our findings confirm that self-regulatory strategies predict providing creative solutions to school tasks (a proxy of creative learning) and mediate the relationship between divergent thinking, creative confidence, and creative learning.
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Russo, Marcello, Ariane Ollier-Malaterre, and Gabriele Morandin. "Breaking out from constant connectivity: Agentic regulation of smartphone use." Computers in Human Behavior 98 (September 2019): 11–19. http://dx.doi.org/10.1016/j.chb.2019.03.038.

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Sripada, Chandra, John D. Swain, S. Shaun Ho, and James E. Swain. "Automatic goals and conscious regulation in social cognitive affective neuroscience." Behavioral and Brain Sciences 37, no. 2 (April 2014): 156–57. http://dx.doi.org/10.1017/s0140525x13002161.

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AbstractThe Selfish Goal model challenges traditional agentic models that place conscious systems at the helm of motivation. We highlight the need for ongoing supervision and intervention of automatic goals by higher-order conscious systems with examples from social cognitive affective neuroscience. We contend that interplay between automatic and supervisory systems is required for adaptive human behavior.
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Ponton, Michael K. "Group Learning Through the Lens of Learner Autonomy." International Journal of Learning and Development 10, no. 2 (June 4, 2020): 23. http://dx.doi.org/10.5296/ijld.v10i2.17144.

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Learner autonomy describes the individual who exercises personal agency in his or her learning. Similar to an individual, groups—that is, collections of people with a defined purpose often represented by organizational subunits—also engage in intentional learning to support and improve existing processes or identify and pursue new opportunities. The purpose of this theoretical discussion is to characterize aspects of intentional group learning using the theoretical framework associated with learner autonomy. Applied to the group level, notions of agentic learning, modes through which agentic learning is exercised, and regulation will be discussed through this lens of autonomy. This discussion may prove useful in describing how organizational groups learn intentionally and in developing processes that improve such learning.
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Woodman, Tim, Lew Hardy, Matthew Barlow, and Christine Le Scanff. "Motives for participation in prolonged engagement high-risk sports: An agentic emotion regulation perspective." Psychology of Sport and Exercise 11, no. 5 (September 2010): 345–52. http://dx.doi.org/10.1016/j.psychsport.2010.04.002.

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Trommsdorff, Gisela. "Development of “Agentic” Regulation in Cultural Context: The Role of Self and World Views." Child Development Perspectives 6, no. 1 (December 9, 2011): 19–26. http://dx.doi.org/10.1111/j.1750-8606.2011.00224.x.

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Willegers, Marley, Tim Woodman, and Flo Tilley. "Agentic emotion regulation in high-risk sport: An in-depth analysis across climbing disciplines." Personality and Individual Differences 204 (April 2023): 112061. http://dx.doi.org/10.1016/j.paid.2022.112061.

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Lee, Han-Sung, and Sang-Kook Kim. "Associations of Self-regulation, Agentic Engagement, Mental Toughness and Perceived Performance for Korean Juvenile Golfers." Journal of Sport and Leisure Studies 71 (February 28, 2018): 405–20. http://dx.doi.org/10.51979/kssls.2018.02.71.405.

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Bandura, Albert. "Reflexive empathy: On predicting more than has ever been observed." Behavioral and Brain Sciences 25, no. 1 (February 2002): 24–25. http://dx.doi.org/10.1017/s0140525x0226001x.

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A model positing that perception of another's affective state automatically generates matching emotional and instrumental responses predicts more than has ever been observed. Reflexive empathicness would produce emotional exhaustion, inhibitory strain, and debilitate everyday functioning. Self-regulation of empathic responses involves, not only reactive inhibition, but agentic proactive control. Pervasive inhumanities involve selective disengagement of empathic restraints through dissociative psychosocial mechanisms.
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Zajenkowski, Marcin, and Michael Dufner. "Why Do Narcissists Care So Much About Intelligence?" Current Directions in Psychological Science 29, no. 3 (June 2020): 261–66. http://dx.doi.org/10.1177/0963721420917152.

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Grandiose narcissists typically pursue agentic goals, such as social status, competence, and autonomy. We argue that because high intelligence is a key asset for the attainment of such agentic goals, the concept of intelligence should play a prominent role in grandiose narcissists’ self-regulation and social behavior. We review the relevant literature and report evidence in support of this claim. Grandiose narcissists consider intelligence to be an important resource that leads to benefits across life domains, they tend to maintain and defend illusory positive intellectual self-views, and they are extremely motivated to appear intelligent to other people. Thus, even though grandiose narcissism is essentially unrelated to objectively assessed intelligence, intelligence nevertheless plays an important role in the way grandiose narcissists think, feel, and behave. We discuss potential implications for social relationships and point toward avenues for future research.
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Dissertations / Theses on the topic "Agentic Regulation"

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Belenguer, Ana. "Analytical studies of some agents for fertility regulation." Thesis, City University London, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335308.

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Furst, Alexander J. "State Regulation of Private Police and Security Agents." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1245626912.

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Casey, Ryan Edward. "Mouse strain-specific splicing of Apobec3." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/950.

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"Host resolution of viral infection is dependent upon components of the innate and acquired immune system. The mammalian protein Apobec3 plays an important role as part of the immune system’s innate defenses through its modification of reverse transcribed viral DNA. Recently, Apobec3 was found to directly inhibit HIV-1 and HBV replication through deaminating newly transcribed deoxycytidine residues to deoxyuridine. The ability of mouse and simian Apobec3 variants to inhibit human retroviruses and vice versa highlights the utility of analyzing cross-species homologues. To better understand this editing enzyme, differentially pathogen-susceptible inbred mice were used as an experimental model. The purpose of this project is to examine the effects of murine Apobec3 (muA3) alternative splicing on its DNA-editing characteristics. Three distinct Apobec3 isoforms were isolated from pathogen-susceptible BALB/cByJ (“C”) inbred mice, and two Apobec3 isoforms came from pathogen-resistant C57BL/6ByJ (“Y”) mice. The five muA3 isoforms were cloned, sequenced, and expressed from a constitutive promoter in a haploid Saccharomyces cerevisia strain. MuA3 DNA-editing activity was measured via the CAN1 forward mutation assay. The five isoforms studied in this project were discovered to be strain-specific. One isoform from each mouse strain mutated the yeast CAN1 locus significantly. Additionally, both muA3 isoform mRNAs derived from the pathogen-resistant Y mice were found to persist at a higher level (2.7 -12.4 fold) than any of the C mouse isoforms. This suggests that the absence of exon 5 or some other signal in the Y mice may influence transcript stability. Evidence also suggests that the murine Apobec3 start codon is actually 33bp upstream of its reference start, with implications for previous research performed using muA3. Sequencing analysis of genomic DNA revealed the presence of a 4bp insertion in a region of BALB/cByJ muA3 which may have disrupted an intronic splicing enhancer signal. Furthermore, a novel BALB/cByJ Apobec3 isoform was characterized. This is the first report of strain-specific processing with regard to muA3."
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Olives, Pons Juana Maria. "Social norms as strategy of regulation of reproduction among hunting-fishing-gathering societies." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669474.

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En comparar les dades demogràfiques dels caçadors-pescadors-recol·lectors moderns (e.g. l’existència d’índexs de creixement demogràfic diferenciats, capacitat d’aconseguir índexs de creixement alts, estabilitat demogràfica a llarg termini) i dels caçadors-pescadors-recol·lectors del Paleolític (e.g. densitat demogràfica baixa, absència de creixement demogràfic) en sorgeix una contradicció. La baixa densitat demogràfica documentada al Plistocè ha estat generalment argumentada com una conseqüència de la inferior capacitat tecnològica, de la biologia intrínseca, o de catàstrofes ambientals i climàtiques. Addicionalment, les societats caçadores-pescadores-recol·lectores han estat també caracteritzades per tindre una fecunditat natural, en oposició a una fecunditat controlada. Durant molt temps, s’ha ignorat el fet que el creixement demogràfic de poblacions caçadores-pescadores-recol·lectores també pot ser controlat a través de la regulació de les relacions socials i reproductives entre els homes i les dones, d’acord amb les seves funcions socials i econòmiques. L’objectiu d’aquesta tesi doctoral és aproximar-se a les relacions socials i reproductives entre els homes i les dones en una societat caçadora-pescadora-recol·lectora. Metodològicament, combino fonts etnohistòriques, estudis etnogràfics, demogràfics, i mèdics en un programa de simulació mulitagent encarregat de simular processos demogràfics. En les simulacions, poso a prova la hipòtesi d’aquesta tesi: les normes socials controlen la reproducció (fecunditat natural) i, conseqüentment, el creixement demogràfic de les societats caçadores-pescadores-recol·lectores. Els resultats obtinguts en aquesta tesi suporten la hipòtesi, assenyalant principalment tres tendències: 1) en les proves de les simulacions que no contenen cap norma social, la població artificial experimenta un creixement demogràfic elevat i ràpid (inexistent en el registre arqueològic o treballs etnogràfics); 2) en les proves de les simulacions que inclouen una restricció mínima, la població artificial mostra un creixement més lent tot i que encara excessivament elevat a llarg termini; 3) en les proves de les simulacions que inclouen una restricció més accentuada, les poblacions assoleixen una estabilitat demogràfica. Per tant, a partir d’aquestes dades es pot concloure que és molt probable que les poblacions caçadores-pescadores-recol·lectores del Paleolític varen desenvolupar determinats mecanismes socials que regularen el seu creixement demogràfic. L’organització i divisió del treball es converteix en la via a través de la qual es distribueix el valor subjectiu de la contribució productiva dels individus que hi participen. Les diferències de les activitats productives en base al sexe fa possible que s’estableixi una interdependència que alhora relativitza el valor del producte obtingut i, per extensió, el valor designat a la gent productora. D’aquesta manera, l’organització del treball, juntament amb la regulació de la reproducció, legitimen l’establiment de desigualtats socials basades en el gènere.
There is an incongruity between the demographic data observed among contemporary hunter-fisher-gatherers (e.g. the existence of different growth rates, the capability of achieving high growing rates, and long-term demographic stability) and that of Pleistocene hunter-fisher-gatherers (e.g. low population density, and a lack of demographic expansion). The low demographic density in the Pleistocene has been explained as a consequence of low technological capability, intrinsic biology, and ecological and climatic catastrophes. In addition to this, the foraging societies have been categorized to follow a natural fertility, in opposition to controlled fertility. For long, it has been neglected that population growth among hunter-fisher-gatherers can also be regulated by controlling the social relations and reproductive relations between men and women, accordingly to the socioeconomic roles they have and, hence, in accordance to a particular socioeconomic behaviour. The aim of this doctoral thesis is to approach to the social and reproductive relations between the men and women in a foraging society in order to identify patterns and interrelations. Methodologically, I take into account ethnohistorical sources, ethnographic studies, modern demographic studies, and medical studies, which I combine into a multi-agent based simulation program that simulates demographic processes. In the simulations, I test the hypothesis presented in this thesis: social norms have an effect on reproduction (natural fertility) and, by extension, on the demographic growth of hunting-fishing-gathering societies. The results obtained in this doctoral thesis support this hypothesis, pointing to three main tendencies: 1) in the simulation in which social norms are excluded, the artificial population experiences a rapid demographic growth (unattested in the archaeological record and ethnographic studies); 2) in the simulations including the less restrictive social norms, the artificial population experiences a slower demographic growth, although it still remains to be unsustainable in the long-term; 3) in the simulations with the most restrictive norms the artificial population is demographically stable. Therefore, it is very plausible that Palaeolithic hunter-fisher-gatherers also developed certain social mechanisms that regulated their demographic growth. The manner in which labour is divided (organized) is at the same time the manner in which the subjective value of the productive contribution of the individuals participating in the production is distributed. The difference in production activities according to sex makes it possible to set an interdependence and at the same time to relativize the value of the product obtained, and by extension, the value assigned to the people producing it. The organization of labour, together with the regulation of reproduction brings together a legitimization of a social inequality based on gender.
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曾紹怡 and Siu-yee Patricia Tsang. "Regulation of cholesterol metabolism in hepatocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969835.

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Tsang, Siu-yee Patricia. "Regulation of cholesterol metabolism in hepatocytes." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22032459.

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Wilson, Heather Louise. "Regulation of calcium mobilisation by pyridine nucleotide metabolites." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298417.

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Mantoni, Tine S. "Regulation of the androgen receptor in response to chemotherapeutic agents." Thesis, Institute of Cancer Research (University Of London), 2006. http://publications.icr.ac.uk/9711/.

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The androgen receptor (AR) is the central component in regulation of the androgen signalling within the prostate gland. Deregulation of the AR activity is frequently involved in the development of prostate cancer. Treatment of advanced prostate cancer often involves chemotherapy and most of these drugs exert their function by generating genotoxic stress such as DNA damage. Although many cellular responses to DNA damage have been clarified over the past years, the effects of genotoxic stress on AR function remain to be elucidated. Here, the effects of genotoxic agents used in chemotherapeutic regimes were investigated in relation to endogenously expressed AR function in the hormone responsive prostate cancer cell line LNCaP. This led to the novel finding that the topoisomerase 11 inhibitors, etoposide and doxorubicin, and the DNA crosslinking agent, cisplatin, inhibited the AR activity. It was further discovered that this loss of AR activity could not be explained by changes in cell cycle distribution, altered nuclear translocation of the AR, reduced expression of the receptor or by induction of apoptosis. Activation of the tumour suppressor p53 is a central component in various cellular responses to genotoxic stress, however, the inhibition of AR activity in response to genotoxic stress was found to be mediated by a mechanism independent of p53 function. Etoposide reduced AR ligand binding within the first hour of androgen exposure, a response only observed to a minor degree after cisplatin treatment. In contrast, cisplatin caused a loss of serine 81 phosphorylation on the AR after 8 hours of drug exposure, which was a response not seen in etoposide treated cells. Interestingly, further studies revealed that at early timepoints both agents inhibited the hormone stimulated recruitment of AR to androgen response elements (AREs) in the promoter and enhancer regions of an AR regulated gene. A possible involvement of MAPK, P13K or cell cycle checkpoint signalling pathways was investigated, but none were found to be directly involved, however, preliminary studies suggest that fully functional HSP90 may be involved in this aspect of AR regulation.
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Ho, Chee-ying Kitty. "A review of regulatory system of the Hong Kong travel industry." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36427548.

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Liu, Teresa T. "Transcriptional regulation of azole antifungal resistance in candida albicans." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-023-Liu-index.html.

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Thesis (M.S.)--University of Tennessee Health Science Center, 2008.
Title from title page screen (viewed on July 31, 2008). Research advisor: P. David Rogers, Pharm.D., Ph.D. Document formatted into pages (xii, 172 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 98-115).
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Books on the topic "Agentic Regulation"

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Ríos, Mario Grau. Exposición laboral a agentes carcinógenos. Las Rozas [Madrid]: La Ley-Actualidad, 1999.

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Research, Colorado Department of Regulatory Agencies Office of Policy and. Bail bonding agent regulation. Denver, Colo: Colorado Dept. of Regulatory Agencies, Office of Policy and Research, 2003.

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Jonathan, Davey, Sainter Séverine, and Aretz Alf, eds. Guide to the commercial agents regulations. 2nd ed. Oxford [England]: Hart Pub., 2003.

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Provenzano, George. Economic considerations in regulating neurotoxic substances. [Washington, D.C.?: Office of Technology Assessment, 1989.

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Virginia. Dept. of Commerce. Regulations governing athlete agents. Richmond, Va: The Dept., 1990.

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Carolina, South. License law and regulations. Columbia, S.C. (1201 Main St., Suite 1500, Columbia 29201): South Carolina Real Estate Commission, 1993.

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Carolina, South. License law and regulations. 2nd ed. Columbia, S.C. (1201 Main St., Suite 1500, Columbia 29201): South Carolina Real Estate Commission, 1990.

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Ṭhāna, Burma Kunʻ svayʻ reʺ Vanʻ krīʺ. Cīʺ pvāʺ reʺ ʼa kyuiʺ choṅʻ myāʺ mhatʻ puṃ taṅʻ khraṅʻʺ ʼa minʻʹ (ʼa minʻʹ ʼa mhatʻ 2/89). [Ranʻ kunʻ]: Praññʻ thoṅʻ cu Mranʻ mā Nuiṅʻ ṅaṃ toʻ ʼA cuiʺ ra, Kunʻ svayʻ reʺ Vanʻ krīʺ Ṭhāna, 1989.

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Regulation, Florida Legislature House of Representatives Committee on Business &. Professional. Regulation of athlete agents in Florida: Chapter 468, Part IX, F.S. [Tallahassee]: The Committee, 1994.

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service), ScienceDirect (Online, ed. Structure, function and regulation of Tor complexes from yeasts to mammals. Amsterdam: Elsevier/Academic Press, 2010.

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Book chapters on the topic "Agentic Regulation"

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Bryant, Peter T. "Self-Regulation." In Augmented Humanity, 169–97. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76445-6_6.

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AbstractTo monitor and manage the dilemmas of digitalization, augmented agents must self-regulate in a collaborative fashion. Artificial agents are advancing rapidly in these respects and some are fully self-generative. They are increasingly capable of complex, fast, sensitive self-regulation. In consequence, augmented agents will have the potential for effective self-regulation and self-supervision. However, human self-regulation is often simplified and sluggish and lacks sensitivity. People rely on habit, routine, and docility, and often with good reasons. Yet, as noted, artificial agents are increasingly hyperactive and hypersensitive, compared to humans. When both agents combine, therefore, artificial self-regulatory functioning could be complex, fast, and precise, while human functioning is relatively simple, sluggish, and heuristic. The result could be self-regulatory divergence or convergence and possibly dysfunction. Further implications then follow for self-efficacy, task engagement, and motivational strength.
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Cai, He, Youfeng Su, and Jie Huang. "Output Regulation." In Cooperative Control of Multi-agent Systems, 185–230. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98377-2_7.

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Grant, Wyn. "Policy Aspects of Regulation." In Regulation of Biological Control Agents, 127–37. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_5.

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Luck, Michael. "Behaviour Regulation and Normative Systems." In Agent and Multi-Agent Systems. Technologies and Applications, 2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-30947-2_2.

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Ehlers, Ralf-Udo. "Regulation of Biological Control Agents and the EU Policy Support Action REBECA." In Regulation of Biological Control Agents, 3–23. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_1.

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Regnault-Roger, Catherine. "Risks of Biocontrol Agents Containing Compounds of Botanical Origin or Semiochemicals." In Regulation of Biological Control Agents, 215–42. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_10.

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De Clercq, Patrick, and Jeffrey S. Bale. "Risks of Invertebrate Biological Control Agents – Harmonia axyridis as a Case Study." In Regulation of Biological Control Agents, 243–55. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_11.

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Hauschild, Rüdiger. "Facilitations in the Regulation of Plant Protection Products Containing Baculoviruses." In Regulation of Biological Control Agents, 259–66. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_12.

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Strauch, Olaf, Hermann Strasser, Rüdiger Hauschild, and Ralf-Udo Ehlers. "Proposals for Bacterial and Fungal Biocontrol Agents." In Regulation of Biological Control Agents, 267–88. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_13.

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Tamm, Lucius, Bernhard Speiser, and Thierry Mercier. "Proposals for Regulation of Botanicals." In Regulation of Biological Control Agents, 289–304. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-3664-3_14.

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Conference papers on the topic "Agentic Regulation"

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Jurkevičius, Vaidas, Raimonda Bublienė, and Dominyka Šeputaitė. "IMPACT OF AGENT’S FICUDIARY DUTIES FOR THE SUSTAINABLE AGENCY RELATIONSHIPS." In 12th International Scientific Conference „Business and Management 2022“. Vilnius Gediminas Technical University, 2022. http://dx.doi.org/10.3846/bm.2022.772.

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In order to ensure the sustainability in agency relationships, the agent must act in accordance with the fidu-ciary duties, the breach of which presupposes the negative legal consequences on the side of the agent. The purpose of this article is to reveal the content of agent’s fiduciary duties and the legal consequences of their breach in Lithuania maefrom a comparative perspective. It is concluded that neither the legal regulation nor the case law in Lithuania dis-closes the content of the agent’s fiduciary duties and the legal consequences of their breach. Therefore, more detailed legal provisions would help to ensure a balance of the rights of the subjects involved in agency relationships.
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Bonini, Rodrigo. "Speeding up Reinforcement Learning for Inference and Control of Gene Regulatory Networks." In LatinX in AI at Neural Information Processing Systems Conference 2019. Journal of LatinX in AI Research, 2019. http://dx.doi.org/10.52591/lxai2019120821.

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Motivated by the desire to understand genomic functions through interactions between genes and gene products, the research in the area of gene regulatory networks has become a very important object of study in recent years. Probabilistic Boolean Networks (PBN), which are rules-based dynamic systems, are some of the most studied mathematical models to represent networks and their regulations. However, frequently their representation, regulation, and interactions between genes are overly complex to learn and control, requiring a complex model. Reinforcement Learning (RL) is an interesting technique to deal with this problem because it can learn solutions without the need of a model. This approach is used to train autonomous agents who can find solutions to complex problems, including those of regulation and relationships between genes. But its classical approaches are slow when having to learn tasks with many states especially when these tasks have multiple goals and agents. Besides that, learning bad solutions can make the learning process even more difficult and slow. Therefore, some RL approaches and techniques need to be tested in order to verify the best way to flexibilize, adapt and improve them to intervene and control the gene networks.
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Yuan, Chengzhi, Fen Wu, and Chang Duan. "Cooperative Output Regulation of Multi-Agent Systems With Switched Leader Dynamics via Smooth Switching." In ASME 2017 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dscc2017-5055.

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This paper deals with the leader-following cooperative output regulation problem for heterogeneous multi-agent systems by considering a switched leader dynamics. The switched leader dynamics is composed by multiple linear models and a switching rule governing the switches among them, which is capable of generating more diverse and sophisticated reference signals so as to enhance the multi-agent system’s capability in coping with more complicated coordination tasks. A novel distributed switching control scheme, namely, the smooth switching control strategy, is proposed to achieve cooperative output regulation performance. Distributed switching stability of the overall network is established using multiple Lyapunov functions from the switching control theory. Moreover, under the proposed design framework, the overall cooperative switching output regulation problem can be decomposed into several independent switching stabilization subproblems, and the associated switching control synthesis conditions for each subproblems are formulated as a set of linear matrix inequalities (LMIs) plus linear algebraic equations. As a result, stabilizing switching rules for the leader and distributed switching protocols for the follower agents can be jointly synthesized via semi-definite programming. A numerical example has been used to demonstrate the effectiveness of the proposed approach.
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"Platinum Polyoxoniobates have a potential as an anticancer agent." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-369.

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"Milk exosomes – perspective agents for drug delivery." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-490.

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Bhouri, Neïla, Flavien Balbo, Suzanne Pinson, and Mohamed Tlig. "Collaborative Agents for Modeling Traffic Regulation Systems." In 2011 IEEE/WIC/ACM International Joint Conferences on Web Intelligence (WI) and Intelligent Agent Technologies (IAT). IEEE, 2011. http://dx.doi.org/10.1109/wi-iat.2011.62.

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"Chemotherapeutic agent cisplatin suppresses stabilin-1-mediated clearance of EGF by tumor-associated macrophage." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-290.

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Schen, Aaron, Baoguo Chen, and Lisa X. Xu. "Preliminary Study of Vascular Endothelial Ca2+ Response to Elevated Temperature." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/htd-24424.

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Abstract Local hyperthermia has been the subject of much research because of its great potential for therapeutic and clinic applications. It has been long recognized that a major factor, which affects tissue temperature elevation and heterogeneity during hyperthermia, is the augmentation of blood flow concomitant with the heating. The heat-induced change in local blood flow can be attributed to sympathetically mediated re-distribution of cardiac output and change in local flow resistance resulting from thermally stimulated regulation in diameters of arterioles. It has been found that the vascular endothelium significantly affects the dynamic response of the vessel diameter to thermal stimuli. Endothelial cells play key regulatory roles by producing several potent vasoactive agents and regulating coagulation states, i.e. endothelium derived relaxing factors (EDRFs). Most endothelial functions depend to various extents on changes in intracellular calcium concentration [Ca2+]i. A new approach to studying vascular thermo-regulation during hyperthermia has been developed in this research to quantitatively measure the dynamic response of vascular endothelial Ca2+ to temperature elevations using confocal fluorescence ratio imaging. The cell membrane permeable fluorescence dye Fura-2/AM esters were loaded into the vascular endothelial cells and ratio imaging of the fluorescent endothelial cell were taken under the excitation of 334 and 380nm wavelengths. The signal intensities were calibrated with the endothelial calcium ion concentration ([Ca2+]i) and temperatures ranged from 37°C to 44°C. This calibration will provide a means to quantitatively measure the vascular endothelial [Ca2+]i transients in in vivo tissue when subjected to temperature elevations from 38°C to 44°C, and thus to further understand the role of endothelium in thermally induced vascular regulation under hyperthermic conditions in the near future.
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Krishna, Sooraj, Catherine Pelachaud, and Arvid Kappas. "Towards an Adaptive Regulation Scaffolding through Role-based Strategies." In IVA '19: ACM International Conference on Intelligent Virtual Agents. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3308532.3329412.

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"Novel aptamer-based targeted agents for boron neutron capture therapy." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-476.

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Reports on the topic "Agentic Regulation"

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Gonzalez-Lira, Andres, and Ahmed Mushfiq Mobarak. Slippery Fish: Enforcing Regulation when Agents Learn and Adapt. Cambridge, MA: National Bureau of Economic Research, March 2021. http://dx.doi.org/10.3386/w28610.

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Borenstein, Severin, Meghan Busse, and Ryan Kellogg. Principal-agent Incentives, Excess Caution, and Market Inefficiency: Evidence From Utility Regulation. Cambridge, MA: National Bureau of Economic Research, December 2007. http://dx.doi.org/10.3386/w13679.

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Sionov, Edward, Nancy Keller, and Shiri Barad-Kotler. Mechanisms governing the global regulation of mycotoxin production and pathogenicity by Penicillium expansum in postharvest fruits. United States Department of Agriculture, January 2017. http://dx.doi.org/10.32747/2017.7604292.bard.

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The original objectives of the study, as defined in the approved proposal, are: To characterize the relationship of CreA and LaeA in regulation of P T production To understand how PacC modulates P. expansumpathogenicity on apples To examine if other secondary metabolites are involved in virulence or P. expansumfitness To identify the signaling pathways leading to PAT synthesis Penicilliumexpansum, the causal agent of blue mould rot, is a critical health concern because of the production of the mycotoxinpatulin (PAT) in colonized apple fruit tissue. Although PAT is produced by many Penicilliumspecies, the factors activating its biosynthesis were not clear. This research focused on host and fungal mechanisms of activation of LaeA (the global regulator of secondary metabolism), PacC (the global pH modulator) and CreA (the global carbon catabolite regulator) on PAT synthesis with intention to establish P. expansumas the model system for understanding mycotoxin synthesis in fruits. The overall goal of this proposal is to identify critical host and pathogen factors that mechanistically modulate P. expansumgenes and pathways to control activation of PAT production and virulence in host. Several fungal factors have been correlated with disease development in apples, including the production of PAT, acidification of apple tissue by the fungus, sugar content and the global regulator of secondary metabolism and development, LaeA. An increase in sucrose molarity in the culture medium from 15 to 175 mM negatively regulated laeAexpression and PAT accumulation, but, conversely, increased creAexpression, leading to the hypothesis that CreA could be involved in P. expansumPAT biosynthesis and virulence, possibly through the negative regulation of LaeA. We found evidence for CreAtranscriptional regulation of laeA, but this was not correlated with PAT production either in vitro or in vivo, thus suggesting that CreA regulation of PAT is independent of LaeA. Our finding that sucrose, a key ingredient of apple fruit, regulates PAT synthesis, probably through suppression of laeAexpression, suggests a potential interaction between CreA and LaeA, which may offer control therapies for future study. We have also identified that in addition to PAT gene cluster, CreA regulates other secondary metabolite clusters, including citrinin, andrastin, roquefortine and communesins, during pathogenesis or during normal fungal growth. Following creation of P. expansumpacCknockout strain, we investigated the involvement of the global pH regulator PacC in fungal pathogenicity. We demonstrated that disruption of the pH signaling transcription factor PacC significantly decreased the virulence of P. expansumon deciduous fruits. This phenotype is associated with an impairment in fungal growth, decreased accumulation of gluconic acid and reduced synthesis of pectolytic enzymes. We showed that glucose oxidase- encoding gene, which is essential for gluconic acid production and acidification during fruit colonization, was significantly down regulated in the ΔPepacCmutant, suggesting that gox is PacC- responsive gene. We have provided evidence that deletion of goxgene in P. expansumled to a reduction in virulence toward apple fruits, further indicating that GOX is a virulence factor of P. expansum, and its expression is regulated by PacC. It is also clear from the present data that PacC in P. expansumis a key factor for the biosynthesis of secondary metabolites, such as PAT. On the basis of RNA-sequencing (RNA-seq) analysis and physiological experimentation, the P. expansumΔlaeA, ΔcreAand ΔpacCmutants were unable to successfully colonize apples for a multitude of potential mechanisms including, on the pathogen side, a decreased ability to produce proteolytic enzymes and to acidify the environment and impaired carbon/nitrogen metabolism and, on the host side, an increase in the oxidative defence pathways. Our study defines these global regulatory factors and their downstream signalling pathways as promising targets for the development of strategies to fight against this post-harvest pathogen.
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von Arnim, Albrecht G. Eukaryotic initiation factor 3 (eIF3) and 5’ mRNA leader sequences as agents of translational regulation in Arabidopsis. Final report. Office of Scientific and Technical Information (OSTI), February 2015. http://dx.doi.org/10.2172/1169186.

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Weil, David. Individual Rights and Collective Agents: The Role of Old and New Workplace Institutions in the Regulation of Labor Markets. Cambridge, MA: National Bureau of Economic Research, March 2003. http://dx.doi.org/10.3386/w9565.

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Horwitz, Benjamin, and Barbara Gillian Turgeon. Secondary Metabolites, Stress, and Signaling: Roles and Regulation of Peptides Produced by Non-ribosomal Peptide Synthetases. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696522.bard.

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Fungal pathogens of plants produce a diverse array of small molecules. Often referred to as secondary metabolites because they were thought to be dispensable for basic functions, they may indeed have central roles as signals for the fungal cell, and in interactions with the host. We have identified more than a dozen genes encoding nonribosomal peptide synthetases (NPS) in Cochliobolusheterostrophus, the agent of southern corn leaf blight. The aim of this project was to identify roles of these genes in stress responses and signaling. The first objective was to test a complete collection of C. heterostrophus nonribosomal peptide synthetase (NRPS)-encoding gene deletion mutant and wildtype (WT) strains for sensitivity to various agents of oxidative (ROS) and nitrosative (RNOS) stress, in vitro. The second objective and next step in this part of the project was to study the relevance of sensitivity to ROS and RNOS in the host pathogen interaction, by measuring the production of ROS and RNOS in planta, when plants are inoculated with wild type and mutant strains. A third objective was to study expression of any genes shown to be involved in sensitivity to ROS or RNOS, in vitro and in planta. Another objective was to determine if any of the genes involved in oxidative or nitrosative stress responses are regulated by components of signal transduction pathways (STP) that we have identified and to determine where mechanisms overlap. Study of the collection of nps mutants identified phenotypes relevant for virulence, development and oxidative stress resistance for two of the genes, NPS2 and NPS6. Mutants in genes related to RNOS stress have no virulence phenotypes, while some of those related to ROS stress have reduced virulence as well as developmental phenotypes, so we focused primarily on ROS stress pathways. Furthermore, the identification of NPS2 and NPS6 as encoding for NRPS responsible for siderophore biosynthesis lent a new focus to the project, regulation by Fe. We have not yet developed good methods to image ROS in planta and work in this direction is continuing. We found that NPS6 expression is repressed by Fe, responding over the physiological Fe concentration range. Studying our collection of mutants, we found that conserved MAPK and G protein signal transduction pathways are dispensable for Fe regulation of NPS6, and initiated work to identify other pathways. The transcription factor SreA is one candidate, and is responsible for part, but not all, of the control of NPS6 expression. The results of this project show that the pathogen contends with oxidative stress through several signaling pathways. Loss of the siderophore produced by Nps6 makes the fungus sensitive to oxidative stress, and decreases virulence, suggesting a central role of the ability to sequester and take up extracellular iron in the host-pathogen interaction. Siderophores, and manipulation of Fe levels, could be targets for new strategies to deal with fungal pathogens of maize and other plants.
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Sweeney, John F. Regulation of Polymorphonuclear Leukocyte (PMN) Survival and Function by Proinflammatory Agents That Are Released as a Consequence of Sulfur Mustard-Mediated Injury. Fort Belvoir, VA: Defense Technical Information Center, February 2004. http://dx.doi.org/10.21236/ada423093.

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Philosoph-Hadas, Sonia, Peter Kaufman, Shimon Meir, and Abraham Halevy. Signal Transduction Pathway of Hormonal Action in Control and Regulation of the Gravitropic Response of Cut Flowering Stems during Storage and Transport. United States Department of Agriculture, October 1999. http://dx.doi.org/10.32747/1999.7695838.bard.

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Original objectives: The basic goal of the present project was to increase our understanding of the cellular mechanisms operating during the gravitropic response of cut flowers, for solving their bending problem without affecting flower quality. Thus, several elements operating at the 3 levels o the gravity-induced signal transduction pathway, were proposed to be examined in snapdragon stems according to the following research goals: 1) Signaling: characterize the signal transduction pathway leading to the gravitropic response, regarding the involvement of [Ca2+]cyt as a mediator of IAA movement and sensitivity to auxin. 2) Transduction by plant hormones: a) Examine the involvement of auxin in the gravitropic response of flower stems with regard to: possible participation of auxin binding protein (ABP), auxin redistribution, auxin mechanism of action (activation of H+-ATPase) mediation by changes in [Ca2+]cyt and possible regulation of auxin-induced Ca2+ action b: calmodulin-activated or Ca2+-activated protein kinases (PK). b) Examine the involvement of ethylene in the gravitropic response of flower stems with regard to auxin-induced ethylene production and sensitivity of the tissue to ethylene. 3) Response: examine the effect of gravistimulation on invertase (associated with growth and elongation) activity and invertase gene expression. 4) Commercial practice: develop practical and simple treatments to prevent bending of cut flowers grown for export. Revisions: 1) Model systems: in addition to snapdragon (Antirrhinum majus L.), 3 other model shoe systems, consisting of oat (Avena sativa) pulvini, Ornithogalun 'Nova' cut flowers and Arabidopsis thaliana inflorescence, were targeted to confirm a more general mechanism for shoot gravitropism. 2 Research topics: the involvement of ABP, auxin action, PK and invertase in the gravitropic response of snapdragon stems could not be demonstrated. Alternatively, the involvement in the gravity signaling cascade of several other physiological mediators apart of [Ca2+]cyt such as: IP3, protein phosphorylation and actin cytoskeleton, was shown. Additional topics introduced: starch statolith reorientation, differential expression of early auxin responsive genes, and differential shoot growth. Background to the topic: The gravitropic bending response of flowering shoots occurring upon their horizontal placement during shipment exhibits a major horticultural problem. In spite of extensive studies in various aboveground organs, the gravitropic response was hardly investigated in flowering shoots. Being a complex multistep process that requires the participation of various cellular components acting in succession or in parallel, analysis of the negative gravitropic response of shoot includes investigation of signal transduction elements and various regulatory physiological mediators. Major achievements: 1) A correlative role for starch statoliths as gravireceptors in flowering shoot was initially established. 2) Differentially phosphorylated proteins and IP3 levels across the oat shoe pulvini, as well as a differential appearance of 2 early auxin-responsive genes in snapdragon stems were all detected within 5-30 minutes following gravistimulation. 3) Unlike in roots, involvement of actin cytoskeleton in early events of the gravitropic response of snapdragon shoots was established. 4) An asymmetric IAA distribution, followed by an asymmetric ethylene production across snapdragon stems was found following gravistimulation. 5) The gravity-induced differential growth in shoots of snapdragon was derived from initial shrinkage of the upper stem side and a subsequent elongation o the lower stem side. 6) Shoot bending could be successfully inhibited by Ca2+ antagonists (that serve as a basis for practical treatments), kinase and phosphatase inhibitors and actin-cytoskeleton modulators. All these agents did not affect vertical growth. The essential characterization of these key events and their sequence led us to the conclusion that blocking gravity perception may be the most powerful means to inhibit bending without hampering shoot and flower growth after harvest. Implications, scientific and agriculture: The innovative results of this project have provided some new insight in the basic understanding of gravitropism in flower stalks, that partially filled the gap in our knowledge, and established useful means for its control. Additionally, our analysis has advanced the understanding of important and fundamental physiological processes involved, thereby leading to new ideas for agriculture. Gravitropism has an important impact on agriculture, particularly for controlling the bending of various important agricultural products with economic value. So far, no safe control of the undesired bending problem of flower stalks has been established. Our results show for the first time that shoot bending of cut flowers can be inhibited without adverse effects by controlling the gravity perception step with Ca2+ antagonists and cytoskeleton modulators. Such a practical benefit resulting from this project is of great economic value for the floriculture industry.
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Weiss, David, and Neil Olszewski. Manipulation of GA Levels and GA Signal Transduction in Anthers to Generate Male Sterility. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580678.bard.

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The original objectives of the research were: i. To study the role of GA in anther development, ii. To manipulate GA and/or GA signal transduction levels in the anthers in order to generate male sterility. iii. To characterize the GA signal transduction repressor, SPY. Previous studies have suggested that gibberellins (GAs) are required for normal anther development. In this work, we studied the role of GA in the regulation of anther development in petunia. When plants were treated with the GA-biosynthesis inhibitor paclobutrazol, anther development was arrested. Microscopic analysis of these anthers revealed that paclobutrazol inhibits post-meiotic developmental processes. The treated anthers contained pollen grains but the connective tissue and tapetum cells were degenerated. The expression of the GA-induced gene, GIP, can be used in petunia as a molecular marker to: study GA responses. Analyses of GIP expression during anther development revealed that the gene is induced only after microsporogenesis. This observation further suggests a role for GA in the regulation of post-meiotic processes during petunia anther development. Spy acts as a negative regulator of gibberellin (GA) action in Arabidopsis. We cloned the petunia Spy homologue, PhSPY, and showed that it can complement the spy-3 mutation in Arabidopsis. Overexpression of Spy in transgenic petunia plants affected various GA-regulated processes, including seed germination, shoot elongation, flower initiation, flower development and the expression of a GA- induced gene, GIP. In addition, anther development was inhibited in the transgenic plants following microsporogenesis. The N-terminus of Spy contains tetratricopeptide repeats (TPR). TPR motifs participate in protein-protein interactions, suggesting that Spy is part of a multiprotein complex. To test this hypothesis, we over-expressed the SPY's TPR region without the catalytic domain in transgenic petunia and generated a dominant- negative Spy mutant. The transgenic seeds were able to germinate on paclobutrazol, suggesting an enhanced GA signal. Overexpression of PhSPY in wild type Arabidopsis did not affect plant stature, morphology or flowering time. Consistent with Spy being an O-GlcNAc transferase (OGT), Spy expressed in insect cells was shown to O-GlcNAc modify itself. Consistent with O-GlcNAc modification playing a role in GA signaling, spy mutants had a reduction in the GlcNAc modification of several proteins. After treatment of the GA deficient, gal mutant, with GA3 the GlcNAc modification of proteins of the same size as those affected in spy mutants exhibited a reduction in GlcNAcylation. GA-induced GlcNAcase may be responsible for this de-GlcNAcylation because, treatment of gal with GA rapidly induced an increase in GlcNAcase activity. Several Arabidopsis proteins that interact with the TPR domain of Spy were identified using yeast two-hybrids screens. One of these proteins was GIGANTEA (GI). Consistent with GI and Spy functioning as a complex in the plant the spy-4 was epistatic to gi. These experiments also demonstrated that, in addition to its role in GA signaling, Spy functions in the light signaling pathways controlling hypocotyl elongation and photoperiodic induction of flowering. A second Arabidopsis OGT, SECRET AGENT (SCA), was discovered. Like SPY, SCA O-GlcNAc modifies itself. Although sca mutants do not exhibit dramatic phenotypes, spy/sca double mutants exhibit male and female gamete and embryo lethality, indicating that Spy and SCA have overlapping functions. These results suggest that O-GlcNAc modification is an essential modification in plants that has a role in multiple signaling pathways.
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Ehrlich, Marcelo, John S. Parker, and Terence S. Dermody. Development of a Plasmid-Based Reverse Genetics System for the Bluetongue and Epizootic Hemorrhagic Disease Viruses to Allow a Comparative Characterization of the Function of the NS3 Viroporin in Viral Egress. United States Department of Agriculture, September 2013. http://dx.doi.org/10.32747/2013.7699840.bard.

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Project Title: "Development of a plasmid-based reverse genetics system for the Bluetongue and Epizootic Hemorrhagic Disease viruses to allow comparative characterization of the function of the NS3 viroporin in viral egress". Project details: No - IS-4192-09; Participants – Ehrlich M. (Tel Aviv University), Parker J.S. (Cornell University), DermodyT.S. (Vanderbilt University); Period - 2009-2013. Orbiviruses are insect-borne infectious agents of ruminants that cause diseases with considerable economical impact in Israel and the United States. The recent outbreaks of BTV in Europe and of Epizootic Hemorrhagic Disease Virus (EHDV) in Israel, underscore the need for: (i) a better comprehension of the infection process of orbiviruses, (ii) the identification of unique vs. common traits among different orbiviruses, (iii) the development of novel diagnosis and treatment techniques and approaches; all aimed at the achievement of more effective control and treatment measures. It is the context of these broad goals that the present project was carried out. To fulfill our long-term goal of identifying specific viral determinants of virulence, growth, and transmission of the orbiviruses, we proposed to: (i) develop reverse genetics systems for BTV and EHDV2-Ibaraki; and (ii) identify the molecular determinants of the NS3 nonstructural protein related to viroporin/viral egress activities. The first objective was pursued with a two-pronged approach: (i) development of a plasmid-based reverse genetics system for BTV-17, and (ii) development of an "in-vitro" transcription-based reverse genetics system for EHDV2-Ibaraki. Both approaches encountered technical problems that hampered their achievement. However, dissection of the possible causes of the failure to achieve viral spread of EHDV2-Ibaraki, following the transfection of in-vitro transcribed genomic segments of the virus, revealed a novel characteristic of EHDV2-Ibaraki infection: an uncharacteristically low fold increase in titer upon infection of different cell models. To address the function and regulation of NS3 we employed the following approaches: (i) development (together with Anima Cell Metrology) of a novel technique (based on the transfection of fluorescently-labeledtRNAs) that allows for the detection of the levels of synthesis of individual viral proteins (i.e. NS3) in single cells; (ii) development of a siRNA-mediated knockdown approach for the reduction in levels of expression of NS3 in EHDV2-Ibaraki infected cells; (iii) biochemical and microscopy-based analysis of the localization, levels and post-translational modifications of NS3 in infected cells. In addition, we identified the altered regulation and spatial compartmentalization of protein synthesis in cells infected with EHDV2-Ibaraki or the mammalian reovirus. In EHDV2-Ibaraki-infected cells such altered regulation in protein synthesis occurs in the context of a cell stress reponse that includes the induction of apoptosis, autophagy and activation of the stressrelated kinase c-Jun N-terminal Kinase (JNK). Interestingly, inhibition of such stress-related cellular processes diminishes the production of infectious virions, suggesting that EHDV usurps these responses for the benefit of efficient infection. Taken together, while the present project fell short of the generation of novel reverse genetics systems for orbiviruses, the development of novel experimental approaches and techniques, and their employment in the analysis of EHDV-infected cells, yielded novel insights in the interactions of orbiviruses with mammalian cells.
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