Relevant bibliographies by topics / Ag/GDC

Academic literature on the topic 'Ag/GDC'

Author: Grafiati
Published: 8 June 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses

Journal articles on the topic "Ag/GDC":

1

Sampath, Deepak, Sylvia Herter, Frank Herting, Ellen Ingalla, Michelle Nannini, Marina Bacac, Wayne J. Fairbrother, and Christian Klein. "Combination of the glycoengineered Type II CD20 antibody obinutuzumab (GA101) and The novel Bcl-2 selective Inhibitor GDC-0199 Results in superior In Vitro and In Vivo Anti-tumor activity in models Of B-Cell Malignancies." Blood 122, no. 21 (November 15, 2013): 4412. http://dx.doi.org/10.1182/blood.v122.21.4412.4412.

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Introduction Obinutuzumab (GA101) is a novel glycoengineered type II, anti-CD20 monoclonal antibody induces a high level of direct cell death. As a result of glycoengineering, GA101 has increased affinity for FcgRIIIa on effector cells resulting in enhanced direct cell death and ADCC induction. GA101 is currently in pivotal clinical trials in CLL, indolent NHL and DLCBL. ABT-199 (GDC-0199) is a novel, orally bioavailable, selective Bcl-2 inhibitor that induces robust apoptosis in preclinical models of hematological malignancies and is currently in clinical trials for CLL, NHL and MM. Based on their complementary mechanisms of action involving increased apoptosis (GDC-0199) or direct cell death (GA101) the combination of anti-CD20 therapy with a Bcl-2 inhibitor has the potential for greater efficacy in treating B lymphoid malignancies. Experimental Methods The combination of GA101 or rituximab with GDC-0199 was studied in vitro utilizing assays that measure direct cell death induction/apoptosis (AxV/Pi positivity) on WSU-DLCL2, SU-DHL4 DLBCL and Z138 MCL cells by FACS and the impact of Bcl-2 inhibition on ADCC induction. In vivo efficacy of the combination of GA101 or rituximab and GDC-0199 was evaluated in SU-DHL4 and Z138 xenograft models. Results GA101 and rituximab enhanced cell death induction when combined with GDC-0199 in SU-DHL4, WSU-DLCL2 and Z138 cell lines. When combined at optimal doses an additive effect of the two drugs was observed. GDC-0199 did not negatively impact the capability of GA101 or rituximab to induce NK-cell mediated ADCC. Combination of GDC-0199 and GA101 induced a greater than additive anti-tumor effects in the SU-DHL4 and Z138 xenograft models resulting in tumor regressions and delay in tumor regrowth when compared to monotherapy. Moreover, continued single-agent treatment with GDC-0199 after combination with GA101 resulted in sustained in vivo efficacy in the SU-DHL4 model. Conclusions Our data demonstrate that the combination of GA101 with GDC-0199 results in enhanced cell death and robust anti-tumor efficacy in xenograft models representing NHL sub-types that is comparable to the combination of rituximab with GDC-0199. In addition, single-agent treatment with GDC-0199 following combination with GA101 sustains efficacy in vivo suggesting a potential benefit in continued maintenance therapy with GDC-0199. Collectively the preclinical data presented here supports clinical investigation of GA101 and GDC-0199 combination therapy, which is currently in a phase Ib clinical trial (clinical trial.gov identifier NCT01685892). Disclosures: Sampath: Genentech: Employment, Equity Ownership. Herter:Roche: Employment. Herting:Roche: Employment. Ingalla:Genentech: Employment. Nannini:Genentech: Employment. Bacac:Roche: Employment. Fairbrother:Genentech: Employment, Equity Ownership. Klein:Roche Glycart AG: Employment.
2

Vernoux, Philippe, Benjamin Gilbert, Angel Caravaca, Stéphanie Bruyère, Sylvie Migot, Pauline Vilasi, and David Horwat. "Ethylene Electrooxidation into Ethylene Oxide on Nanostructured Ag/GDC Electrocatalysts." ECS Meeting Abstracts MA2021-02, no. 27 (October 19, 2021): 837. http://dx.doi.org/10.1149/ma2021-0227837mtgabs.

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3

Rehman, Saeed Ur, Muhammad Haseeb Hassan, Syeda Youmnah Batool, Seung Bok Lee, Hye-Sung Kim, Rak-Hyun Song, Tak-Hyoung Lim, Jong-Eun Hong, Seok Joo Park, and Dong Woo Joh. "Fabrication of Durable and High-Performance Flat Tubular Anode-Supported Solid Oxide Cells for Stack Application." ECS Transactions 111, no. 6 (May 19, 2023): 557–64. http://dx.doi.org/10.1149/11106.0557ecst.

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Solid oxide cell (SOC) technology is highly admissible for distributed power generation since it enables the most efficient and clean conversion of fuels into energy and heat. SOCs are also regarded as a potential technology for their decisive role in strengthening the hydrogen economy concept by storing renewable energy resources such as green hydrogen and synthetic fuels. In this work, high-performance and durable flat tubular anode-supported SOC is developed for SOC stack applications. NiO-8YSZ composite flat tubular anode support is fabricated by employing an extrusion process. Anode functional layer and electrolyte layers are deposited by the dip-coating technique, whereas the GDC diffusion barrier, LSCF-GDC composite cathode, and Ag-glass composite interconnect layers are fabricated by the conventional screen-printing process. Finally, the prepared flat tubular SOCs possess an active cathode area of 45 cm2 and demonstrated a high-power density of ~430 mW cm-2 at operating current density, voltage, and temperature conditions of 501 mA cm-2, 0.87 V, and 700 °C. During a long-term stability test at 700 °C for 1000 h, the SOC showed a voltage improvement of 0.013 % while operating at a fuel efficiency of 65%. The flat tubular anode-supported SOC’s high performance and durable operation showed its potential for commercial applications in distributed power generation and hydrogen production. Together with the research to further enhance the SOC’s performance and stability, the flat tubular SOC stack design and fabrication are also in progress.
4

Raju, Kati, Muksin, and Dang-Hyok Yoon. "Reactive air brazing of GDC–LSCF ceramics using Ag–10 wt% CuO paste for oxygen transport membrane applications." Ceramics International 42, no. 14 (November 2016): 16392–95. http://dx.doi.org/10.1016/j.ceramint.2016.07.042.

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5

Raźniak, Andrzej, Magdalena Dudek, and Piotr Tomczyk. "Reduction of oxygen at the interface M|solid oxide electrolyte (M=Pt, Ag and Au, solid oxide electrolyte=YSZ and GDC). Autocatalysis or artifact?" Catalysis Today 176, no. 1 (November 2011): 41–47. http://dx.doi.org/10.1016/j.cattod.2011.04.030.

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6

Biswas, Saheli, Aniruddha P. Kulkarni, Daniel Fini, Sarbjit Giddey, and Sankar Bhattacharya. "In situ synthesis of methane using Ag–GDC composite electrodes in a tubular solid oxide electrolytic cell: new insight into the role of oxide ion removal." Sustainable Energy & Fuels 5, no. 7 (2021): 2055–64. http://dx.doi.org/10.1039/d0se01887b.

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In situ synthesis of methane in a single-temperature zone SOEC in the absence of any methanation catalyst is a completely electrochemical phenomenon governed by the thermodynamic equilibrium of various reactions.
7

Sakitou, Y., A. Hirano, N. Imanishi, Y. Takeda, Y. Liu, and M. Mori. "La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3 – Ag Composite Cathode for Intermediate-Temperature Solid Oxide Fuel Cells." Journal of Fuel Cell Science and Technology 5, no. 3 (May 27, 2008). http://dx.doi.org/10.1115/1.2930764.

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The composite electrode of La0.6Sr0.4Co0.2Fe0.8O3 (LSCF) and Ag was examined as an air electrode for intermediate-temperature solid oxide fuel cells. Two types of LSCF/Ag composite electrodes were prepared. One was made by firing the printed sheet of LSCF-GDC (10mol%Gd2O3 doped CeO2)-Ag powder mixture on the GDC/8mol%Y2O3 doped zirconia (YSZ) electrolyte, and the other was prepared by firing the LSCF electrode on GDC/YSZ infiltrating a AgNO3 solution in the pores of the electrode. In both cases, the cathode polarization overpotentials were reduced by the addition of Ag into LSFC. The power density of anode support cells with the LSCF electrode was increased from 0.28W∕cm2to0.34W∕cm2 at 600°C by infiltrating a AgNO3 solution into the electrode.
8

Liu, Y., K. Yasumoto, S. Hashimoto, K. Takei, M. Mori, Y. Funahashi, Y. Fijishiro, A. Hirano, and Y. Takeda. "Development of Ceria Based SOFCs With a High Performance La0.6Sr0.4Co0.2Fe0.8O3−δ–Ce0.9Gd0.1O1.95–Ag Composite Cathode." Journal of Fuel Cell Science and Technology 7, no. 6 (August 17, 2010). http://dx.doi.org/10.1115/1.3176220.

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In this work, a microtubular cell consisting of a thin Ce0.9Gd0.1O1.95 (GDC) electrolyte (thickness: below 10 μm) on a support NiO/GDC anode (1.8 mm outer diameter, 200 μm wall thickness) with a La0.6Sr0.4Co0.2Fe0.8O3−δ/GDC functional cathode has been developed for intermediate/low temperature operation. The functional cathode was prepared by in situ infiltrating the electrochemically catalytic nano-Ag particles into the as-established 20 μm thick cathode. The as-proposed Ag-impregnation route ensures a very homogeneous particle dispersion and a good adhesion of Ag to the ceramic matrices. The cells were successfully operated to produce the maximum power densities of 0.41 W cm−2 (1.27 A cm−2, 0.32 V), 0.83 W cm−2 (2.23 A cm−2, 0.37 V), and 1.05 W cm−2 (2.39 A cm−2, 0.44 V) at 450°C, 500°C, and 550°C, respectively.
9

Oki, Kentaro, Edward B. Arias, and Gregory D. Cartee. "Prior Treatment with the AMPK Activator AICAR Induces Subsequently Enhanced Glucose Uptake in Isolated Skeletal Muscles from Old Rats." FASEB Journal 31, S1 (April 2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.lb726.

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Prior treatment of isolated skeletal muscles from young rats (≤4 months‐old) to the 5′ adenosine monophosphate‐activated protein kinase (AMPK) activator 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside (AICAR) in the presence of serum can induce elevated insulin‐stimulated glucose uptake (GU) several hours after of removal of the muscles from AICAR and serum. Previous research did not determine if both AICAR and serum were required for the observed effect on insulin‐dependent GU, or if incubation with either was sufficient. Earlier research also has not evaluated the effects of prior AICAR incubation with and without serum on the GU of muscles from older rats. Accordingly, we examined the separate and combined effects of AICAR and serum on subsequent insulin‐independent and insulin‐dependent GU in skeletal muscles from aged rats (23–24 month old; n=20). Both epitrochlearis muscles from each rat were dissected and split into two separate muscle strips. Each muscle strip underwent a four‐step incubation. During step 1 (60 minutes), one muscle strip from each animal was incubated with: Krebs‐Henseleit Buffer (KHB) alone, KHB with AICAR, serum alone, or serum with AICAR. During step 2 (180 minutes), all muscle strips were incubated with KHB. During steps 3 (30 minutes) and 4 (20 minutes), all 4 strips from 10 rats were incubated without insulin, and all 4 strips from the remaining 10 rats were incubated with insulin. During step 4, muscle strips were incubated with radiolabeled 3‐O‐methyl‐D‐glucose and the same insulin concentration as the previous step. Repeated measures analysis of variance (RM ANOVA) in the basal (no insulin) group indicated a significant interaction (serum × AICAR) for insulin‐independent GU. In the insulin group, RM ANOVA revealed a significant main effect of AICAR on insulin‐dependent GU without a significant main effect of serum or significant serum × AICAR interaction. Our working hypothesis is that the elevated insulin‐independent GU after combined AICAR and serum incubation is secondary to subsequently elevated phosphorylation of TBC1D1 on Ser237 (an AMPK‐phosphosite), and the AICAR‐induced elevation of insulin‐dependent GU is secondary to subsequently elevated phosphorylation of TBC1D4 on Ser711 (an AMPK phosphosite) and Thr642 (an Akt‐phosphosite).Support or Funding InformationNIA Training Grant AG 000114 and NIA R01 AG10026 (GDC)

Dissertations / Theses on the topic "Ag/GDC":

1

Kaseman, Brian J. "An Investigation of Secondary Formations of High Temperature Solid Oxide Fuel Cells." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1330648584.

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2

Gilbert, Benjamin. "Synthèse de films nanocomposites Ag/YSZ, Ag/CGO & Ag(Cu)/CGO par pulvérisation cathodique magnétron réactive pour l’électrocatalyse de l’éthylène en oxyde d’éthylène." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0257.

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L’oxyde d’éthylène (OE) est un précurseur de nombreuses réactions de chimie fine. Il est produit par la réaction d’époxydation de l’éthylène sur un catalyseur à base d’argent. Néanmoins, afin d’atteindre des sélectivités élevées, le procédé industriel utilise des additifs chlorés dans la phase gaz peu écologiques et des modérateurs alcalins sur le catalyseur. L’objectif de cette étude est d’augmenter la sélectivité vers OE sans utilisation de promoteurs chlorés grâce à des électrocatalyseurs Ag/oxydes à structure fluorite synthétisés en couche mince par pulvérisation cathodique magnétron en atmosphère réactive à haute pression. Durant les tests de catalyse les électrocatalyseurs ont été polarisés dans des cellules en configuration 3 électrodes dédiées à la promotion électrochimique de la catalyse, EPOC. Trois systèmes poreux (Ag/YSZ, Ag/CGO & Ag(Cu)/CGO) ont été développés par pulvérisation cathodique magnétron. Le film Ag/YSZ 4 Pa 25 mA présente une microstructure botryoïde caractéristiques d’une séparation des charges d’argent et de la matrice YSZ. Le film nanocomposite Ag/CGO 4 Pa 70 mA présente une morphologie ouverte de type cerveau avec des nano porosités débouchantes. Enfin, le film Ag(Cu)/CGO 4 Pa 70 mA est constitué de nanofils hydrophobes multiphasés entropique. Durant les tests en conditions d’époxydation de l’éthylène en milieu réducteur, le film Ag/CGO 4 Pa 70 mA a présenté un maximum de sélectivité vers OE de 16,55 % à 220 °C et, sous polarisation, la sélectivité a pu être augmentée de 2,78 % sans modification de la vitesse de réaction par effet NEMCA
Ethylene oxide (EO) is an essential building block for the chemical industry. It is produced by the ethylene epoxidation reaction over a silver-based catalyst. Nevertheless, to achieve high selectivity, industrial processes use chloride additives in the gas phase and alkaline moderators on the catalyst. The aim of this study is to increase EO selectivity without chloride additives thanks to Ag/fluorite oxides electrocatalysts synthesized by reactive magnetron sputtering and incorporated in a 3-electrodes configuration cell designed for electrochemical promotion of catalysis, EPOC. Three porous systems (Ag/YSZ, Ag/GDC, Ag(Cu)/GDC) have been synthesized by reactive magnetron sputtering. Ag/YSZ 4 Pa 25 mA nanocomposite thin film exhibits a botryoidal microstructure characteristic of silver segregation inside the YSZ matrix. Ag/GDC 4 Pa 70 mA nanocomposite thin film exhibits a brain like-morphology with open nanoporosities. Ag(Cu)/GDC 4 Pa 70 mA nanocomposite thin film consists of multi-phase hydrophobic entropic nanowires. During catalytic tests under ethylene epoxidation conditions in reducing medium, Ag/GDC 4 Pa 70 mA showed the maximum EO selectivity of 16.55 % at 220 °C and, under polarization, selectivity boost of 2.78 % occur without the appearance of NEMCA effect
3

Lin, Jhih-ming, and 林志名. "The Study of Sputter-Deposited CeO2,GDC and Ag-CeO2 Thin Films for Resistive Oxygen Sensors." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/99235907517183812689.

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碩士
國立臺灣科技大學
材料科技研究所
96
In this thesis, we deposit CeO2,(Gd2O3)x-(CeO2)1-x and Ag- CeO2 thin films on Al2O3 substrate by using magnetron sputtering process, anneal the films, then deposit Pt as electrode to fabricate resistive-type oxygen sensor, analyze its electronal properties, activation energy, and sensors sensitivity of CeO2 thin film, and correlate to their microstruture. Finally, we measure the oxygen sensor’s response time at high temperature(750℃) and low temperature(450℃) and fabricate the resistive oxygen sensors which have good sensitivity and fast response time. The CeO2 thin film deposited on Al2O3 substrate were continuous and dense. Their structure and crystallinity were verified by XRD. The structure and particle sizes of CeO2 films were stablilized by annealing at 750℃,1000℃, and 1250℃ for 5 hours. This approach was also applicable to GDC thin films. Ag-CeO2 composite thin films were deposited by sputtering Ag-CeO2 inlaid targets. Ag particles were dispersed in CeO2 , verified by TEM and Auger. After annealing, the Ag-CeO2 films at 600℃ for 1 hour and 5 hours. Different Ag weight fractions of 5.9%, 3.7% and 2.9% were obtained by EDX analysis. In this study, we measure the sensor’s resistance by changing the oxygen concentration in steady condition, and do the dynamic measurement by changing the oxygen concentration rapidly and recording its response time in osciscope and keithley 2410. We discover that the CeO2 thin film oxygen sensor’s response time is related to it’s heat treatment. The higher heat treatment, temperature the slower response time. With high temperature treatment, CeO2 grain become bigger, the grain boundary become less, so transmitting path become less. In high temperature, GDC sensor has the shortesrresponse time. In low temperature, Ag-CeO2 and GDC sensors have shortresponse time. The CeO2 Oxygen sensors annealed at 750℃, 1000℃ and 1250℃ have response times of 350 ms, 1.5s and 3s tested in 750℃ by changing oxygen partial pressure from 0 Torr to 152 Torr, GDC and Ag-CeO2 oxygen sensors (with 750℃ heat treatment) have response times of 350 ms and 500 ms, tested at 450℃. CeO2 thin films have good sensitivity then GDC and Ag-CeO2 thin films. GDC sensor has better sensitivity in low test temperature than high test temperature. Ag- CeO2 sensors also behave the same, but become unstable in high test temperature because of Ag diffusion and separation. Finally, we calculated the activation energies of CeO2 thin films for different annealing temperature, The higher annealing temperature, the higher activation energy. The activation energy of CeO2 sensor with no heat treatment is 1.23 ev, and the activation energies of CeO2 sensor with 750℃, 1000℃ and 1250℃ heat treatment are 1.55 ev, 1.69 ev and 1.81ev. The activation energy of GDC and Ag-CeO2 thin films are 1.1 ev and 0.73 ev which are lower than those of CeO2 thin film.

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