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1
Harris-Reeves, Brooke. "Behaviour Management Strategies of Beginning AFL Coaches." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/366567.
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This thesis investigates the behaviour management practices used by beginning AFL coaches. It examines beginning coaches’ perceptions of their role, and whether they believe it is their responsibility to manage athlete behaviour. The nature of coaching is multifaceted requiring them to take on many responsibilities. Consequently, coaches can have both a positive and negative effect on the athletes they train. Negative effects range from athlete drop out, injuries, and loss of confidence. On the other hand, positive effects include engaged and motivated athletes, increased self esteem and low attrition rates. It is for this reason that coaches need to ensure they create positive environments for athletes. A postmodern ethnographic approach was used to explore the experiences of AFL beginning coaching candidates. Data was collected via questionnaires, interviews and observations. Data analysis techniques were employed to identify themes and issues around beginning coach’s perceptions, strategies and practices in managing athlete behaviour. Analysis also included the use of a methodological tool that was developed, pilot tested and implemented as a mechanism for evaluating the effectiveness of behaviour management practices.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith Business School
Griffith Business School
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Al-Nashwan, Ahmed Mohammed. "Writing competence in Arabic : AFL/ASL problem solving strategies." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399867.
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Said, Pace Doreen. "Assessment for Learning (AfL) in one Maltese state college." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/21381/.
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Assessment is a complex landscape. Debates about whether summative or formative assessment, or a combination of both, offers the best approach to assess students’ learning have been dominating international and local literature for years. This study seeks to further enrich these discussions by looking into the relationship between the beliefs and practices about Assessment for Learning (AfL) of Maltese state primary school teachers in one college. A college is a cluster of primary, middle and secondary schools within a particular geographical region. Furthermore, this study takes a step forward in investigating the influence of a collaborative action research approach on the teachers’ beliefs and practices about AfL. Throughout the study, positivism is resisted and the guiding theoretical framework is social constructionism based on an interpretive paradigm. This investigation was carried out in two phases over the span of one year, the first phase in May-June 2014 and the second phase from September 2014 to June 2015. The first phase consists of collecting data from two open-ended questionnaires with eighty-five teachers and eight Heads of Schools. The second part of the study consists of a nine-month long study with three teachers who were new to AfL. These participants took on the role of action researchers to improve their class situations by embedding a set of AfL strategies in their lessons. Multiple data sources including group discussions, individual feedback sessions, record-keeping booklets, semi-structured interviews with the teachers and their students and teachers’ self-written stories were utilised. Both research phases generated rich qualitative data which were analysed from a qualitative content analysis lens. Data coding and analysis were assisted by NVIVO. Findings of the first phase indicate that the overarching situation consists in a positive level of thought, which is accompanied by a limited understanding and a higher degree of mechanical AfL practice. Thus, the relationship is a divergent to a convergent one, therefore a complex one. This link transcends into degrees of semi-complex (Early Years) to a complex (Junior Years) relationship at the particular year group levels. Findings from the collaborative action research part show that this mode of teachers’ professional learning had an overall positive influence on the beliefs-to-practice relationship, albeit to different degrees of improvement. Nonetheless, the participants still ended with a wobbly belief about AfL having the same effect on all the students. This thesis argues that the belief about the pedagogy is also underpinned by the teachers’ perceptions of the students’ attitudes and motivation towards learning. Thus, the teachers’ perceptions of the students are affecting their expectations and perspectives of the success, or otherwise, of AfL. Hence, the belief to practice relationship is a matter of degree.
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Campbell, Emma E. "Relocation Stories: experiences of Indigenous Footballers in the AFL." Thesis, Full-text, 2008. https://vuir.vu.edu.au/1993/.
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Moving away from home to embark on a career at an elite level involves the individual within a broader social ecology where a range of factors influence the dynamic transition. In 2000, Indigenous and non-Indigenous past and present AFL footballers and AFL administrative staff suggested that relocation was one of the issues faced by Indigenous AFL footballers. The focus of the current study was to learn about relocation and settlement experiences from the perspectives of 10 Indigenous Australian AFL footballers, examining the social, cultural, organisational, and psychological challenges. Five participants were drafted to the AFL within 12 months, and five participants were drafted to the AFL prior to 2002. Participants were listed players from seven Victorian AFL clubs. Interviews were also conducted with eight representatives (Indigenous and non-Indigenous) from organisations associated with the AFL. Players were asked questions about their own relocation and settlement experiences. Secondary informants were asked questions about their involvement with Indigenous players relocating and their perception of the relocation process for Indigenous players in the AFL. Interviews were semi-structured and conversational in style and analysed for unique and recurring themes using Interpretive Phenomenological Analysis (IPA). Each of the stories reflected subtle differences experienced during relocation, highlighting the importance and value of using a phenomenological and qualitative framework to understand each player’s perspective and experiences of relocation. The findings demonstrated both facilitative and barrier factors influencing the relocation, settlement, and adaptation experiences. These included opportunity and social mobility, social support and kindredness, culture shock, and racism and homogeneity. Each player’s story about relocation and subsequent settlement and adaptation, highlighted the importance of family, connection, and kindredness as an overarching theme. The findings emphasise the need for receiving environments, in this case the AFL, to treat every player on an individual basis rather than grouping them into a collective. It is essential that a player is understood in relation to his socio-cultural context. The AFL has implemented significant changes to welcome cultural diversity, but as a mainstream organisation, it has been developed within mainstream values. Just as society in general needs to acknowledge Australian history and the overall discrepancies between Indigenous and non-Indigenous opportunities and living standards, the AFL has to continue to de-institutionalise stereotypes and increase the cultural awareness of all groups to continue being a forerunner of progressive race relations. The current study represents an important initial step in the identification and description of the relocation processes from the vantage point of Indigenous footballers.
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Campbell, Emma E. "Relocation Stories experiences of Indigenous Footballers in the AFL /." Full-text, 2008. http://eprints.vu.edu.au/1993/1/emma_campbell.pdf.
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Moving away from home to embark on a career at an elite level involves the individual within a broader social ecology where a range of factors influence the dynamic transition. In 2000, Indigenous and non-Indigenous past and present AFL footballers and AFL administrative staff suggested that relocation was one of the issues faced by Indigenous AFL footballers. The focus of the current study was to learn about relocation and settlement experiences from the perspectives of 10 Indigenous Australian AFL footballers, examining the social, cultural, organisational, and psychological challenges. Five participants were drafted to the AFL within 12 months, and five participants were drafted to the AFL prior to 2002. Participants were listed players from seven Victorian AFL clubs. Interviews were also conducted with eight representatives (Indigenous and non-Indigenous) from organisations associated with the AFL. Players were asked questions about their own relocation and settlement experiences. Secondary informants were asked questions about their involvement with Indigenous players relocating and their perception of the relocation process for Indigenous players in the AFL. Interviews were semi-structured and conversational in style and analysed for unique and recurring themes using Interpretive Phenomenological Analysis (IPA). Each of the stories reflected subtle differences experienced during relocation, highlighting the importance and value of using a phenomenological and qualitative framework to understand each player’s perspective and experiences of relocation. The findings demonstrated both facilitative and barrier factors influencing the relocation, settlement, and adaptation experiences. These included opportunity and social mobility, social support and kindredness, culture shock, and racism and homogeneity. Each player’s story about relocation and subsequent settlement and adaptation, highlighted the importance of family, connection, and kindredness as an overarching theme. The findings emphasise the need for receiving environments, in this case the AFL, to treat every player on an individual basis rather than grouping them into a collective. It is essential that a player is understood in relation to his socio-cultural context. The AFL has implemented significant changes to welcome cultural diversity, but as a mainstream organisation, it has been developed within mainstream values. Just as society in general needs to acknowledge Australian history and the overall discrepancies between Indigenous and non-Indigenous opportunities and living standards, the AFL has to continue to de-institutionalise stereotypes and increase the cultural awareness of all groups to continue being a forerunner of progressive race relations. The current study represents an important initial step in the identification and description of the relocation processes from the vantage point of Indigenous footballers.
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Stebbins, Danialle. "Championing Labor: Labor Diplomacy, the AFL-CIO, and Polish Solidarity." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1588083656196024.
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Welborn, Ronny D. "On Viewing Press Releases of the Texas State AFL-CIO as Rhetorical Genre." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc500348/.
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Previous scholarship on labor rhetoric has concentrated on the impact of declining union membership and contemporary activist strategies on the part of unions. The press release is a common form of communication that organized labor employs in order to reach its publics. This study explores the press releases of the Texas State AFL-CIO to determine to what extent this level of labor discourse meets the criteria of a rhetorical genre. This study employs the methodology for generic criticism laid out by Foss for identifying genres. The study concludes that a genre of labor rhetoric exists and that the genre was used extensively to promote the Texas State AFL-CIO as a socially-conscious and politically motivated organization.
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Medová, Alena. "Analýza aplikace statistických metod v podniku AFL Stříbro. Porovnání s požadavky VDA." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-3851.
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Peplow, Amber Leigh. "Creating change in the SEIU and the AFL-CIO: The role of identity." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/2263.
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The SEIU and the AFL-CIO utilized similar rhetorical strategies in creating identification to further change within their organizations. Despite similar rhetorical strategies, the change efforts differ substantially in terms of success. This dissertation argues that the audience, culture and organizational structure influence the success of the change effort. The dissertation provides implications for rhetorical communication in labor unions.
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Rayner, Russell. "Training and testing of 1v1 agility in Australian football." Thesis, Federation University Australia, 2020. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/173773.
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Little is known of how agility events occur in the sport of Australian football (AF). As a result, appropriate training and testing methods are unknown. This thesis investigated 1v1 agility in AF to evaluate alternative methods for training and testing agility. The thesis was undertaken in three studies. Study one investigated if training and testing practices used in elite AF align with the demands of competition. A notational analysis revealed substantial variation in movement patterns used by, and the cognitive demands of, athletes in agility events. A survey of high-performance managers in the AFL revealed that a mixture of open and closed training methods are used in elite AF, and that subjective agility assessment is preferred to formal testing. Study two assessed the reliability and ecological validity of a field-based test of attacking and defending agility for AF. The text exhibited excellent inter-rater and intra-rater reliability, as well as moderate test-retest reliability. Characteristics of the test were compared to the notational analysis to assess the ecological validity of the test. While the test did not fully replicate the agility demands of AF, the test improved ecological validity when compared to previous tests described in the literature. Study three evaluated the effectiveness of a four-week 1v1 training intervention for improving attacking and defending agility in Australian footballers. In addition, the study assessed the crossover of attacking training to defending agility and defending training to attacking agility. Improvements in attacking agility were found which were greater for attacking-trained athletes. However, no improvements in defending agility were realised. This thesis indicates that 1v1 training and testing is suitable for assessing and developing agility in Australian footballers. However, 1v1 training may be more suitable for improving attacking agility. Further, agility is context-specific, and testing and training should consider the role of the athlete.Doctor of Philosophy
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Ellis, Mark W. "Speciation, Species Concepts, and Biogeography Illustrated by a Buckwheat Complex (Eriogonum corymbosum)." DigitalCommons@USU, 2009. https://digitalcommons.usu.edu/etd/370.
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The focus of this research project is the complex of infraspecific taxa that make up the crisp-leaf buckwheat species Eriogonum corymbosum (Polygonaceae), which is distributed widely across southwestern North America. This complex provides an ideal taxonomic group for research into population relationships and speciation. To avoid unnecessary debates about taxonomic validity or contentious issues regarding appropriate species definitions, the historical evolution of the species concept is first reviewed in detail, demythologizing an often-assumed species problem. Following that review, the E. corymbosum complex is examined specifically.
Although eight varieties of E. corymbosum are currently recognized based on morphological characters, this group of large, woody shrubs has a history of revisions that demonstrates the uncertainty inherent in circumscriptions based on morphology alone. The apparent rarity of some E. corymbosum varieties also presents conservation and management challenges, demonstrating the need for taxonomic verification.
To bring greater resolution to this group, I genetically tested samples from populations of six of the eight varieties of E. corymbosum, as well as a number of related buckwheat species. With 103 AFLP loci and chloroplast sequence data from 397 samples, I found strong support for the designation of the recently named E. corymbosum var. nilesii. This predominantly yellow-flowered variety had previously been considered part of a more common variety, and thus its management had not been of particular concern. But as a separate variety, its known distribution is quite limited, and management for this rare plant is now advised.
An examination of the biogeography of the E. corymbosum complex provides further support for the apparent rarity of var. nilesii, as well as var. aureum. Both taxa are found at the periphery of the complex, and both may represent insipient species. While all other varieties appear more closely related to each other than to varieties aureum and nilesii, with overlapping ranges confined mostly to the Colorado Plateau, both var. aureum and var. nilesii appear to have allopatric ranges largely off the Colorado Plateau. It appears these two peripheral varieties may each entail a separate center of origin for two new taxa.
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Nováček, Aleš. "Simulátor určení souřadnic senzorových uzlů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218275.
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Many applications that use senzor data from a wireless senzor network require corresponding node position information as well, information from the senzors is useful only if node location information is also available. There are many ways to get information about location of senzor, but some are expensive and inefficient. My work presents fully decentralized algorithm AFL (anchor-free localization) for localization of wireless sensors. Aim of my master´s thesis is to describe main features and advantages of AFL and to create program that simulates localization process.
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Bass, George Nelson III. "Organized Labor and U.S. Foreign Policy: The Solidarity Center in Historical Context." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/752.
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During the Cold War the foreign policy of the American Federation of Labor and Congress of Industrial Organizations (AFL-CIO), was heavily criticized by scholars and activists for following the lead of the U.S. state in its overseas operations. In a wide range of states, the AFL-CIO worked to destabilize governments selected by the U.S. state for regime change, while in others the Federation helped stabilize client regimes of the U.S. state. In 1997 the four regional organizations that previously carried out AFL-CIO foreign policy were consolidated into the American Center for International Labor Solidarity (Solidarity Center). My dissertation is an attempt to analyze whether the foreign policy of the AFL-CIO in the Solidarity Center era is marked by continuity or change with past practices. At the same time, this study will attempt to add to the debate over the role of non-governmental organizations (NGOs) in the post-Cold War era, and its implications for future study.
Using the qualitative “process-tracing” detailed by of Alexander George and Andrew Bennett (2005) my study examines a wide array of primary and secondary sources, including documents from the NED and AFL-CIO, in order to analyze the relationship between the Solidarity Center and the U.S. state from 2002-2009. Furthermore, after analyzing broad trends of NED grants to the Solidarity Center, this study examines three dissimilar case studies including Venezuela, Haiti, and Iraq and the Middle East and North African (MENA) region to further explore the connections between U.S. foreign policy goals and the Solidarity Center operations.
The study concludes that the evidence indicates continuity with past AFL-CIO foreign policy practices whereby the Solidarity Center follows the lead of the U.S. state. It has been found that the patterns of NED funding indicate that the Solidarity Center closely tailors its operations abroad in areas of importance to the U.S. state, that it is heavily reliant on state funding via the NED for its operations, and that the Solidarity Center works closely with U.S. allies and coalitions in these regions. Finally, this study argues for the relevance of “top-down” NGO creation and direction in the post-Cold War era.
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Gomes, Filho Sandro Mascena. "Purificação, caracterização e atividades biológicas de uma lectina da esponja marinha Aplysina fulva (AFL)." Universidade Federal da Paraíba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/3663.
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A new lectin was purified and characterized from marine sponge Aplysina fulva (AFL). The crude extract was obtained with Tris HCl 0.1 M pH 7.4 containing NaCl 0.15 M buffer. Haemagglutinating activity detection and soluble protein measurement were performed with the crude extract and after each purification step. Isolation of AFL was performed by affinity chromatography in Sepharose CL 4B column, and the retained peak was applied in a DEAE Sephacel ion exchange chromatography column. Analysis of DEAE Sephacel retained peak on polyacrylamide gel electrophoresis (SDS-PAGE) showed the presence of a single band with approximately 27.5 kDa. Under non-denaturating conditions it shows the presence of a single 57 kDa band. The novel lectin showed large amount of hydrophobic amino acids, high temperatures resistance and better hemagglutination activity in the range of neutral to alkaline pHs. AFL was able to inhibit the growth of strains of P. aeruginosa, C. albicans and C. tropicalis. The lectin did not show toxic effects on cells of breast cancer, but had agglutination effect on Leishmania brasiliensis promastigotes by recognizing galactose residues on its surface.
Uma nova lectina foi purificada e caracterizada a partir da esponja marinha Aplysina fulva (AFL). O extrato bruto foi produzido a partir da solubilização de proteínas em solução tampão Tris HCl 0,1 M pH 7,4 NaCl 0,15 M, sendo este utilizado na realização dos ensaios de atividade hemaglutinante e dosagem de proteínas pelo método de Bradford. O primeiro passo de purificação de AFL foi por meio de cromatografia de afinidade em coluna de Sepharose CL 4B. O pico não retido foi eluido com o mesmo tampão de extração e o pico retido foi eluido com tampão Glicina 0,1 M pH 2,6 NaCl 0,15 M. O mesmo foi dialisado, liofilizado e ressuspendido em Tris HCl 0,025 M pH 7,6 e submetido a cromatografia de troca iônica em DEAE Sephacel. A análise do pico retido da DEAE Sephacel por eletroforese nativa em gel de poliacrilamida (PAGE) mostrou a presença de uma única banda com aproximadamente 57 kDa, como também uma única banda com aproximadamente em 27,5 kDa em presença de SDS (PAGE-SDS). A nova lectina apresenta uma grande quantidade de aminoácidos hidrofóbicos, mostrando-se resistente a altas temperaturas e com melhor atividade hemaglutinante na faixa de pH neutro a alcalino. AFL foi capaz de inibir o crescimento de cepas de P. aeruginosa, C. albicans e C. tropicalis. A nova lectina não apresentou efeitos tóxicos para células de câncer de mama, entretanto mostrou-se hábil em aglutinar formas promastigotas de Leishmania brasiliensis através do reconhecimento de galactose em sua superfície.
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Al-Shuwairekh, Saleh. "Vocabulary learning strategies used by AFL (Arabic as a Foreign Language) learners in Saudi Arabia." Thesis, University of Leeds, 2001. http://etheses.whiterose.ac.uk/187/.
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This study investigates vocabulary learning strategies used by AFL learners in Saudi Arabia. It seeks to explore the relationship between vocabulary strategy use and success. Further, the study - aims to examine the effect of certain individual, situational and social factors on the use of vocabulary learning strategies. The methodological approach adopted for this study is a combination of a 'multiple cases' approach and survey. The purpose of the multiple cases is to identify vocabulary learning strategies employed by successful and less successful learners of Arabic. The survey, on the other hand, has been conducted to examine variations in vocabulary strategy use according to the following factors: students' first language, proficiency level, level of achievement, course type, the variety of Arabic used out of class, and religious identity. The results of the multiple cases demonstrate that there are major differences between the two groups of students in the seven categories of vocabulary learning adopted in this study, namely, non-dictionary strategies for discovering the meanings of new words, dictionary use, note-taking, memorization, practice, metacognitive strategies, and expanding lexical knowledge. Moreover, the data of the multiple cases identified three levels of strategies. The first level is termed the 'main strategy level', which includes the seven main categories mentioned above. The second and third levels are termed the 'strategy level' and the 'substrategy level' respectively. The multiple cases data also show that students seem to use vocabulary learning strategies in particular combinations and certain orders. The results of the survey indicate that the two situational factors (course type and variety of Arabic used out of class)investigated in this study seem to have a fairly strong relationship with vocabulary strategy use. The individual factors (students' first language proficiency level and level of achievement) examined in this study,on the other hand, appear to have a very weak relationship with the use of vocabulary learning strategies and finally the social factor (religious identity) appears to have some relationship with vocabulary strategy use.
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Pink, Matthew Andrew. "Relationships between AFL player off-field activity, player characteristics, the club environment, and on-field engagement." Thesis, Australian Catholic University, 2015. https://acuresearchbank.acu.edu.au/download/5a778c5c73591043299bd418bd6f1fbcd970e654b16345fecff77a1c56b7125f/4887986/Pink_2015_AFL_Player_Off_field_Activity.pdf.
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With the increasing professionalisation of the Australian Football League (AFL), greater demands are being placed upon AFL players with respect to their technical, tactical, and physiological training, in addition to increased requirements to promote their club’s brand via community appearances. Modern AFL players have an additional challenge as their careers will be typically limited to, at best, a decade or slightly more at the elite level. This means that they are also encouraged to develop an alternative career for when their playing days are over. Thus, given these demands, there is substantial challenge for the modern footballer in achieving a sense of balance between work and non-work life whilst also preparing for their next career. Although there is a strong ethical argument to support professional athletes’ off-field activities and development away from the field, there is also a growing argument from some coaches and athletes that participating in these activities actually carries some benefit for the way athletes perform in their sport. Such an argument is consistent with contemporary human resource and management literature where in demanding professions, the support of employee work-life balance and holistic development has been shown to be associated with employee engagement and productivity. Within the AFL however there has been mixed views concerning the value of supporting player off-field activities and preparations for life after football. This is understandable given that there is often an underlying assumption in elite sport that to be successful you must ‘out work’ those you are competing with. The present thesis sought to investigate the potential value that participation in off-field activities associated with their lives away from football (i.e., their social, recreational, and career development activities) may have with respect to AFL players’ experience of engagement in their roles as footballers.
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Salmi, T. (Tuukka). "Very small families generated by bounded and unbounded context-free languages." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292743.
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Abstract
In this thesis, we will study very small full trios and full AFLs inside the family of context-free languages. Especially, we are interested in the existence of the smallest nontrivial full trios and full AFLs. This is an old research subject, and it has not been studied much since the 1970s. A conjecture by Autebert et al. states that there does not exist a nontrivial minimal full trio inside the family of context-free languages (2) (see also (1)). First, we will show that there does not exist a nontrivial minimal full trio or a nontrivial minimal full AFL with respect to the bounded context-free languages. This result solves another old conjecture stated by Autebert et al. (1). Then we will try to generalize our result to also concern unbounded context-free languages. We will make some progress, but the problem still remains open.
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Schwab, Laura M. "Incidence, mechanisms and risk factors for shoulder injuries in community Australian football players." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/398438.
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Background: Australian football is a physically demanding sport. Exposure to multidirectional body contact and the necessity for complex upper body skills can result in significant strain on regions such as the shoulder. Despite the rise in incidence and high recurrence of shoulder injuries reported at the elite Australian Football League (AFL) level there is limited evidence available to determine whether shoulder injuries are also a problem at a community level. The financial ramifications of shoulder injuries for the community AFL player and society can be considerable due to time off work, treatment costs and the high number and expense of emergency department presentations.
Objectives: The aim of this thesis was to evaluate the profile (incidence, severity, mechanisms and clinical management) of shoulder complex injuries in community-level AFL players using automated injury surveillance (SMS text messaging and online survey). The thesis also aimed to investigate whether factors identified during preseason (i.e. musculoskeletal screening, measurement of habitual activity levels, or in-season training workload) were related to shoulder, head or neck time-loss injuries.
Methods: Study 1 and 2 prospectively evaluated a novel, automated method of injury surveillance in community AFL players (during a 20-week season) to assess method feasibility (Chapter 3) and to evaluate the profile of shoulder injuries (Chapter 4). In study 3, video footage of elite AFL players (n = 26) retrospectively examined the biomechanical aetiology of injuries to the shoulder complex (Chapter 5). The final two prospective cohort studies (4 and 5) examined potential risk factors for upper body injuries with similar injury mechanisms. At baseline, community AFL players were assessed using seven screening tests of the upper body, trunk and whole-body function to identify any relationships with in-season injuries to the shoulder, head, or neck (Chapter 6). Screening reference values were also determined. Pre-season habitual activity levels and in-season training workloads were collected to prospectively identify associations with in-season injuries to the upper or lower body regions (Chapter 7).
Results: The automated method of injury surveillance was deemed feasible for reporting injuries in community AFL players. The incidence of injuries to the shoulder complex was reported to be high (2nd highest in matches, 4th overall; 10.4% of all injuries). The severity of these shoulder injuries was mostly mild (<3 games missed), but a substantial number required medical attention (emergency department or doctor). Results also indicated activity mechanisms of injury were body region dependent with the majority of upper body injuries (shoulder, head and neck) due to collision contact. Injuries common to lower body regions (thigh, knee and ankle) were from non-contact/ overuse mechanisms. Video analysis of biomechanical aetiology identified that the majority of shoulder injuries occurred with the arm below 100 degrees flexion/ abduction and were caused by lateral contact (34.6%) and hyperflexion/ abduction (19.2%) mechanisms; potentially unavoidable contact injuries. This study found limited evidence to support the use of the suite of musculoskeletal screening tests selected for the upper body, trunk and whole-body function to identify risk of in-season injuries to the shoulder, head or neck. Furthermore, the results identified the variable nature of total workload characteristics in community AFL players, however, no total workload relationships were identified with common in-season injuries to the upper or lower body.
Conclusions: Shoulder injuries are problematic for community AFL players and the use of feasible methods of injury surveillance may help overcome the challenges associated with collecting shoulder injury data in community team sport. The musculoskeletal screening tests and measures of training and habitual workload selected and investigated in this thesis, however, were unable to adequately detect players ‘at-risk’ of an in-season injury to the shoulder, head or neck region. Future studies could investigate different intrinsic risk factors to the ones selected in this study and results also suggest that examination of extrinsic factors (such as rule changes) could possibly be indicated with an aim of preventing shoulder injuries. Furthermore, results from video analysis of elite players may suggest that prophylactic strategies should be customised to the positions of shoulder injury and also focus on lateral contact injury prevention in community AFL players. Findings from this thesis may help to inform the development of injury prevention strategies and guide future research directions with an aim of decreasing injuries to the shoulder complex in community AFL players.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School Allied Health Sciences
Griffith Health
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Boulard, Céline. "Caractérisation biochimique du complexe AFL et identification des partenaires de LEC2 lors du développement de la graine." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS402/document.
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Les spermaphytes majoritairement représentés par les angiospermes ou plantes à fleur, ont le trait fondamental de pouvoir se multiplier par la formation de graine. Les graines représentent un caractère essentiel pour la survie des plantes, leur dissémination et un usage important pour l’industrie, notamment agro-alimentaire. Lors de la formation de la graine, des transitions cruciales ont lieu, en particulier pour le développement, l’établissement des réserves, la maturation, l’acquisition de la tolérance à la dessiccation et la dormance. Ces étapes sont régulées par des facteurs de transcription et notamment les LAFL (LEC1, ABI3, FUS3, LEC2). Les LAFL sont composés de deux familles, les facteurs de transcription à domaine B3 (ABI3, FUS3, LEC2) et les NF-Y (LEC1), qui sont impliqués dans la régulation génique dans différentes étapes du développement de la graine. Des études suggèrent la possibilité de la formation d’un complexe composé de ABI3, LEC1 et LEC2 sur le promoteur de l’OLEOSINE1 permettant d’activer plus fortement la transcription du gène. Néanmoins la caractérisation des protéines, leur action, régulation et leur capacité à interagir entre elles et former un complexe, restent encore méconnues. Dans un premier temps, je me suis attachée à caractériser la formation du complexe protéique composé d’ABI3, LEC1 et LEC2, plus particulièrement, l’interaction entre LEC1 et LEC2. La localisation subcellulaire des deux protéines par étiquetage in planta, ou grâce à des anticorps spécifiques, leur interaction dans un système double hybride et la mesure de l’effet de LEC1 sur LEC2 par thermophorèse ont permis de montrer que LEC2 et LEC1 peuvent former un dimère sur le promoteur de l’OLEOSINE1 et que cette association change l’affinité de LEC2 pour son ADN cible. Dans une deuxième approche, j’ai cherché à identifier des partenaires avec (données bibliographiques) et sans (approche de TAP-tag) a priori pour compléter l’étudeThe spermaphytes predominantly represented by angiosperms or flowering plants, have the fundamental ability to disseminate through seeds. Seeds are essential for the survival of plants, their dissemination and important resource for industry, especially food industry. During seed formation, critical transitions occur, in particular for development, establishment of reserves, maturation, acquisition of desiccation tolerance and dormancy. These steps are regulated by transcription factors and especially LAFL (LEC1, ABI3, FUS3, LEC2). LAFLS are composed of two families, B3 domain containing transcription factors (ABI3, FUS3, and LEC2) and NF-Y (LEC1) that are involved in gene regulation in different stages of seed development. Studies have suggested the possibility that a complex composed of ABI3, LEC1 and LEC2 is formed on the promoter of OLEOSINE1, allowing activating the transcription of the gene. Nevertheless, the characterization of proteins, their action, regulation and their capacity to interact with each another and form a complex, are still unknown. In a first step, I focused on characterizing the formation of the protein complex composed of ABI3, LEC1 and LEC2, more particularly on the interaction between LEC1 and LEC2. The subcellular localization of the two proteins were followed by labelling in planta, or by means of specific antibodies, their interaction tested in a double hybrid system and the measurement of the effect of LEC1 on LEC2 validated by thermophoresis. All the results demonstrated that LEC2 and LEC1 can form a dimer on the promoter of OLEOSINE1 and that this association change the affinity of LEC2 for its target DNA. In a second approach, I sought to identify partners with (bibliographic data) and without (TAP tagging approach) a priori to complete the study
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Gabbe, Belinda, and belinda gabbe@deakin edu au. "The descriptive epidemiology of Australian football injuries presenting to sports medicine clinics." Deakin University. School of Health Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20080603.160908.
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Sports injury prevention has been the focus of a number of recent public health initiatives due to the acknowledgement that sports injuries are a significant public health problem in Australia Whilst Australian football is one of the most popular participation sports in the country, only very limited data is available about football injuries The majority of sports injury data available for this sport is from hospital emergency departments and elite-level injury surveillance Overall there is a paucity of data from treatment settings other than hospitals In particular, there is a lack of information about the injuries sustained by community-level, junior and recreational Australian football participants.
One good potential source of football injury data is sports medicine clinics. Analysis of injury presentations to sports medicine clinics was undertaken to provide a detailed description of the epidemiology of Australian football injuries that present to this treatment setting and to determine the implications for injury prevention in this sport. In addition, the data from sports medicine clinics was compared with existing sources of Australian football injury data to determine how representative sports medicine clinic data is of other football injury data sources and to provide recommendations for future injury surveillance n Australian football.
The results contained in this thesis show that Australian football is the sport most associated with injury presentation at sports medicine clinics. The majority of injured Australian football players presenting to sports medicine clinics are community-level or junior participants which suggests that sports medicine clinics are a good source of information on the injuries sustained by sub-elite football participants.
Competition is the most common context in which Australian football players presenting to sports medicine clinics are injured. The major causes of injuries to Australian football players are being struck by another player, collisions and overuse. Injuries to Australian football players predominantly involve the lower limb. Adult players, players who stopped participating immediately after noticing their injury and players with overuse injuries are the most likely to sustain a more severe injury (i.e. more than four weeks before a full return to football participation and a moderate/significant amount of treatment expected). The least experienced players (five or less years of participation) are more likely to require a significant amount of treatment than the more experienced players.
The prevention of lower limb injuries, injuries caused by body contact and injuries caused by overuse should be a priority for injury prevention research in Australian
football due to the predominance of these injury types in the pattern of Australian football injuries Additionally, adult players, as a group, should be a focus of injury prevention activities in Australian football due to the association between age and injury severity.
Overall, the pattern of Australian football injuries presenting to sports medicine clinics appears to be different than reported by club-based and hospital emergency department injury surveillance activities. However, detailed comparison of sports medicine clinic Australian football data with other sources of Australian football injury data is difficult due to the variable methods of collecting and reporting injury information used by hospital emergency department and club-based injury surveillance activities. The development of a standardised method for collecting and reporting injury data in Australian football is strongly recommended to overcome the existing limitations of data collection in this sport.
In summary, sports medicine clinics provide a rich source of Australian football injury data, especially from the community and junior levels of participation. The inclusion of sports medicine clinic data provides a broader epidemiological picture of Australian football injuries. This broader understanding of the pattern of Australian football injuries provides a better basis for the development of injury prevention measures in this sport.
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Hayward, Eric H. "No Free Kicks : The Experiences of an Aboriginal Family in Australian Rules Football." Curtin University of Technology, Centre for Aboriginal Studies, 2002. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=13910.
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Aboriginal people make a great contribution to Australian sport in conditions of considerable adversity, and yet their contribution goes largely unacknowledged. This study investigates the experiences of one Aboriginal family with an extensive history of involvement with Australian Rules Football using methodologies which seek, and value, Aboriginal perspectives on their involvement. It privileges Indigenous knowledge. The study focuses particularly on the involvement of the Hayward family in Australian Rules Football - the game they love - and in which they have been intensely involved for many generations. The study describes how the Haywards of southwest Western Australia, like most Aboriginal families, experienced an extensive period of colonisation in which their social and cultural autonomy and power were eroded. The historical experience of Aboriginal Australians is vastly different to that of mainstream Australians, and grossly inequitable, not only in terms of economic and educational opportunity, but also in terms of access to sporting opportunities. In many ways, the story of the Hayward family is representative of the experiences of many Black sportsmen and women over the past hundred years. It is suggested that, in order to understand Aboriginal participation and foster the development of Aboriginal sportspeople of all ages, an understanding of the context of their lives is crucial. This study then, explores my extended family's experiences as participants in mainstream sport. It describes how the Haywards, like their community contemporaries, have confronted the limited opportunities afforded to them in their ambitions to gain access, equity of participation, and appropriate reward for effort in their sporting endeavours.Over many generations of Aboriginal participation in the game, there has been considerable inequality of opportunity to enter and participate. In their efforts to participate, members of the Hayward family faced many obstacles unacknowledged by non-Aboriginal players, administrators and spectators. The study shows that many of these obstacles had little to do with the sporting prowess of the Haywards. Every past and present player interviewed as part of this research told of circumstances where they felt that they had not been given a fair go - be it by an umpire, a team official, opposing players, players from their own team, or the crowd. For every case of acceptance of Aboriginal players by a football club, there are many stories of rejection by other clubs. Despite these obstacles, the study found that the Haywards (like many Aboriginal people) see sport (and particularly football) as significant in their lives. They love the game but, equally importantly, they believe that sporting prowess can open a path of entry to mainstream society, provide important economic advantages and offer opportunities for broader social participation while maintaining strong traditions of Aboriginal virtuosity and relationships. The study concludes by suggesting that, despite the adversities encountered by this family in their desire to participate in football, there has been much in the game that has brought pleasure, a sense of success, satisfaction and achievement to them. While this is the story of one family, I believe it provides important insights into experiences common to many Aboriginal families and sportspersons, and that this research deepens our understanding of Australian social history. Football has been, and continues to be, a valued part of the lives of many Aboriginal people.
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Hogue, Michael S. "An analysis of the AFL-CIO's union summer program the college recruited organizers' contributions to the labor movement /." Connect to resource, 2005. http://hdl.handle.net/1811/5869.
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Thesis (Honors)--Ohio State University, 2005.Title from first page of PDF file. Document formatted into pages: contains 18 p.; also includes graphics. Includes bibliographical references (p. 17-18). Available online via Ohio State University's Knowledge Bank.
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Brument, Sami. "Ligands multivalents pour l'interaction par effet chélate avec les récepteurs nicotiniques et les lectines AFL et DC-SIGN." Thesis, Nantes, 2016. http://www.theses.fr/2016NANT4029.
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Les reconnaissances cellulaires sont souvent promues par des interactions multiples et simultanées entre des ligands et leurs récepteurs spécifiques. Ce principe de multivalence a inspiré la communauté scientifique pour accroitre l’affinité d’un ligand synthétique son récepteur. Différents effets de multivalence ont été identifiés parmi lesquels l’effet chélate basé sur l’interaction simultanée d’un ligand avec plusieurs sites de reconnaissance d’une protéine. Nous avons développé durant cette thèse trois séries ligands multivalents pour obtenir un effet chélate avec trois cibles : les récepteurs nicotiniques et les lectines AFL et DC-SIGN. Aspergillus fumigatus est un pathogène adhérant aux récepteurs fucosylés via la lectine hexavalente AFL. Nous avons développé des fucosides di-, hexa- et polyvalent dont les affinités pour AFL ont été évaluées par microcalorimétrie et par test cellulaire. Cela nous a permis d’identifier un ligand hexavalent capable d’inhiber l’adhésion cellulaire des spores d’ A. fumigatus à des concentrations micromolaires. DC-SIGN est une lectine tétramérique reconnaissant les motifs mannose et utilisée comme voie d’entrée infectieuse par le cytomégalovirus. Plusieurs structures à faible et haute valence (2, 4 et 89) de mannose nous ont permis d’obtenir des composés très affins pour cette lectine avec des IC50 de l’ordre du nanomolaire lors de tests d’adhésion cellulaire. Enfin, nous avons développé des séries de composés multivalents pour l’interaction avec les récepteurs nicotiniques pour une application potentielle aux maladies neurodégénératives. Ces ligands ont montré des propriétés antagonistes de l’acétylcholine sur des récepteurs de type α7Cell recognitions are often promoted by multiple and simultaneous interactions between ligands and their specific receptors. This concept of multivalency has inspired the scientific community to increase the affinity of a synthetic ligand for his receptor. Various effects of multivalency have been identified, including the chelate binding mode based on the simultaneous interactions of a ligand with several binding sites of a protein. During this thesis, we have developed three families of multivalent structures to reach a chelate binding mode with three proteins: the nicotinic receptors and the DCSIGN and AFL lectins. Aspergillus fumigatus is a pathogen adhering to the fucosylated receptors through the hexavalent lectin AFL. We have developed di-, hexa and polyvalent fucosides whose affinities for AFL were evaluated by microcalorimetry and cellular assays. We identified a hexavalent ligand able to inhibit the cell adhesion of A. fumigatus spores at micromolar concentrations. DC-SIGN is a tetrameric lectin binding to mannose units, used in an infectious pathway by the cytomegalovirus. Several structures at low and high valency (2, 4 and 89) of mannose allowed us to reach high affinity for this lectin with IC50 in nanomolar range in the cell adhesion tests. Finally, we developed a series of multivalent compounds to interact with the nicotinic receptors for an application in neurodegenerative diseases. These ligands have shown antagonist properties on acetylcholine α7 type receptor
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Weaver, Janet Kay. "Pearl McGill and the promise of industrial unionism: button workers, the women's trade union league and the AFL." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6876.
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This dissertation explores the boundaries of industrial unionism within and outside of the American Federation of Labor (AFL) in the struggle over what direction the American labor movement would take in the Progressive Era. The experiences of Iowa button worker and labor activist Pearl McGill in two nationally significant strikes between 1911 and 1912 enable us to see more clearly the nuances and ambiguities of these boundaries as industrial workers sought to build more inclusive unions. McGill’s advocacy for both the AFL-affiliated and industrially organized button workers in Iowa and the campaign of textile workers in Lawrence, Massachusetts, assisted by the Industrial Workers of the World (IWW), to organize on an industrial basis, shine a light on the conundrum faced by AFL leaders. The AFL and its craft union affiliates held fast to an anachronistic approach to organizing in an environment of rapid and technologically transformative industrialization in which the labor of women and ethnic and racial minorities was critical. The AFL’s early federal labor unions, for which Iowa button workers provide a case study, exemplify the strength of the impulse for unionization among mass production workers and show how AFL leaders fostered an institutional response to the growing demand for industrial unions while ensuring that craft unionists continued to dominate the AFL.
The Women’s Trade Union League (WTUL) walked a fine, and sometimes precarious, line between its loyalty to the AFL and the demand of working women—notably in the garment and textile industries—for new, inclusive forms of organization. The strikes of women button workers and Lawrence textile workers illustrate the predicament faced by WTUL leaders. Pearl McGill’s short but prominent career as a youthful leader of the Muscatine button workers, a spokesperson for the WTUL, an advocate for women strikers, and a prominent activist with the IWW in Lawrence illuminates these tensions and the appeal of industrial unionism for young working women.
This study elevates the importance of Progressive Era federal labor unions as a bridge connecting the local assemblies of the Knights of Labor of the 1880s to the industrial unions that would emerge in the 1930s. It examines the institutional history of the AFL and its bitter struggle with the Knights and establishes the link between the local assemblies of the Knights and the first generation of AFL-affiliated federal labor unions that provided a precedent for later industrial unions. The arc of industrial unionism in the United States can thus be seen as a long, interconnected movement rooted in the principles of general unionism embodied by the Knights and animated by the vital impulse for industrial unionism carried forward by industrially-organized workers of which Iowa button workers provide an important example.
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Harrison, Isabel D. "State and labour in the U.S. : the Carter administration and the AFL-CIO, 1976-1980 : political strategy and the National Accord." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:61edc432-a93d-4892-9c4b-a1c90591fb8c.
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The Accord was a political exchange whereby the labour leadership participated in the wage restraint programme in return for consultative rights and specific quid pro quo policies, including countercyclical measures to offset fiscal austerity. The President subsequently sustained a policy of fiscal and monetary restraint despite the approaching election and the increasing protests of organized labour. However, in the face of strong opposition from some of Carter's senior economists, the labour leaders secured significant modifications to the second year of the pay standard. The 1980 presidential election renewed incentives for continuing cooperation when economic policy otherwise jeopardized relations.
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Rooks, Anne MacPherson. "Working for change young reformers in labor unions and public schools /." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1467894161&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Tran, Thi Duyen. "An exploratory study of the current assessment practices for improving the learning of English as a foreign language (EFL) in two Vietnamese universities." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84622/1/Thi%20Duyen_Tran_Thesis.pdf.
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This case study investigated EFL assessment practices at one public and one private university to explore the support of assessment for English language learning (ELL) within the Vietnamese sociocultural context. Findings demonstrated the potential of assessment to engage students in learning; enhance their understanding of the learning objectives; and facilitate their learning reflection. Findings also identified strong influences of contextual factors such as teachers' language assessment literacy, high-stakes testing and institutional administrative policies on the practices of assessment for ELL. This study contributes to research on Assessment for Learning and EFL education at tertiary level in Vietnam and other similar sociocultural contexts.
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Giorgini, Giacomo. "Analisi e implementazione di algoritmi per il self-positioning." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16643/.
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Nell'ambito della geolocalizzazione ha preso largo uso il GPS (sistema di posizionamento globale), grazie al quale è possibile ottenere una stima della posizione di un terminale dotato dell'apposito sensore. Dato che il GPS riesce a fornire un'accuratezza variabile dai 3 ai 30 metri, per alcune applicazioni (soprattutto indoor) può essere importante adottare un diverso sistema di posizionamento. Questi sistemi, denominati comunemente RTLS (Real-Time Locating Systems), sono costituiti da nodi che, interagendo tra loro, riescono a localizzare un terminale a patto che questo si trovi nell'area coperta da tale rete. Come nel caso dei satelliti del GPS, anche in una rete di RTLS è necessario conoscere la posizione dei nodi ancora che costituiscono l'infrastruttura. Considerando di non voler stimare la posizione dei nodi manualmente è necessario introdurre un meccanismo di autolocalizzazione grazie al quale la rete riesce a procurarsi le coordinate (relative o assolute) dei nodi che la compongono. Una delle sfide più importanti e interessanti nel campo della geolocalizzazione è proprio il "self-positioning", definito come la capacità della rete di autolocalizzare i nodi ancora che la compongono. A tal proposito, in questo lavoro si è voluto analizzare e implementare un particolare algoritmo di self-positioning, ossia l'AFL. Attraverso la rappresentazione di una rete di RTLS tramite la teoria dei grafi, vengono studiati, analizzati e simulati, diversi casi reali in cui risulta particolarmente importante affidarsi ad un sistema di localizzazione diverso dal GPS.
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Johansson, Viktor, and Alexander Vallén. "Random testing with sanitizers to detect concurrency bugs in embedded avionics software." Thesis, Linköpings universitet, Programvara och system, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153310.
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Fuzz testing is a random testing technique that is effective at finding bugs in large software programs and protocols. We investigate if the technology can be used to find bugs in multi-threaded applications by fuzzing a real-time embedded avionics platform together with a tool specialized at finding data races between multiple threads. We choose to fuzz an API (available to applications executing on top) of the platform. This thesis evaluates aspects of integrating a fuzzing program, AFL and a sanitizer, ThreadSanitizer with an embedded system. We investigate the modifications needed to create a correct run-time environment for the system, including supplying test data in a safe manner and we discuss hardware dependencies. We present a setup where we show that the tools can be used to find planted data races, however slowdown introduced by the tools is significant and the fuzzer only managed to find very simple planted data races during the test runs. Our findings also indicate what appear to be conflicts in instrumentation between the fuzzer and the sanitizer.
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Galipeau, Miriam. "A Case Study of Alberta’s Future Leaders Program (AFL): Developing Aboriginal Youth Leadership through Cross-cultural Mentorship, and Sport, Recreation, and Arts Programming." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23535.
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In this thesis, in which I use the stand-alone paper format, I employ a Foucauldian lens to examine Alberta’s Future Leaders (AFL), an Aboriginal youth leadership development program. In the first paper, I identify how power relations shape AFL, including its ambitions and struggles towards developing sustainable programming. In the second paper, I examine AFL’s cross-cultural approach to mentorship and the ways in which failing to address issues of culture (re)produces colonial relations of power. Overall, my findings highlight the importance of recognizing and problematizing the power relations at work within Aboriginal youth leadership development initiatives.
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Cook, Martin. "An analysis of the effects upon ITET students' learning and self-efficacy when adopting the principles and practices of Assessment for Learning (AfL)." Thesis, Cardiff Metropolitan University, 2012. http://hdl.handle.net/10369/3995.
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Assessment within higher education is pervasive (Leathwood, 2005). The necessity for marks and grades creates a strong summative assessment environment and can dominate students’ thoughts (Crisp, 2012). However, there is a growing body of evidence suggesting that formative interventions over a learning period can ameliorate improvements in learning and achievement (Macfarlane-Dick, 2006; Gibbs, 2006; Black and Wiliam, 1998). This research project is an action-based investigation of student teachers’ learning and self-efficacy and focuses upon a second year (level 5) cohort studying for a BA (Hons) Primary Education degree with qualified teacher status (QTS). The evidence of the impact of formative assessment upon performance (Black and Wiliam, 1998; Juwah et al., 2004) provided a theoretical base underpinning my research project. Data on students’ responses to the implementation of a range of Assessment for Learning (AfL) strategies, assessment processes and their self-efficacy were collected by means of questionnaires, semi-structured interviews and analysis of assignment results. The data indicated that interventions such as staggered submission of assignments and changes to tutor pedagogy, impacted upon students’ performance. The largest gains were demonstrated by those achieving the lowest marks, although improvements were noted across the cohort. Changes in self-efficacy were evident and interesting results occurred when investigating sophistication of students’ assessment definitions linked to their performance. Issues on how best to implement formative assessment strategies within a dominant summative assessment model are central to the project and the thesis concludes with recommendations on how higher education institutions can help create a more ‘assessment literate landscape’.
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Gustafsson, Marcus, and Oscar Holm. "Fuzz testing for design assurance levels." Thesis, Linköpings universitet, Programvara och system, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138841.
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With safety critical software, it is important that the application is safe and stable. While this software can be quality tested with manual testing, automated testing has the potential to catch errors that manual testing will not. In addition there is also the possibility to save time and cost by automating the testing process. This matters when it comes to avionics components, as much time and cost is spent testing and ensuring the software does not crash or behave faulty. This research paper will focus on exploring the usefulness of automated testing when combining it with fuzz testing. It will also focus on how to fuzzy test applications classified into DAL-classifications.
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Pfudl, Tomáš. "Vyhledávání nejvzdálenějšího prvku v bezdrátové senzorové síti." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-218926.
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Master’s thesis in the first part focuses on the effectiveness of communication in the selection of reference nodes during the anchor-free localization in WSN. In this part two anchor-free localization algorithms AFL and CRP are explored. Knowledge learned on the selection of reference nodes and communication complexities of these algorithms are used in the second part. The second part is aimed at eliminating weaknesses in communication and subsequently proposed a new algorithm for selection of references. The principle of the newly proposed algorithm CASRU (Centralized Algorithm for Selection of Reference Nodes) is based on the principle of CRP. CASRU algorithm builds logical tree structure and then filters the communication through it. New algorithm achieves much greater success in the selection in randomly distributed networks while reducing the amount of communication load.
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Tolgfors, Björn. "Bedömning för vilket lärande? : En studie av vad bedömning för lärande blir och gör i ämnet idrott och hälsa." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56017.
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This dissertation deals with the didactic consequences of assessment for learning (AfL) in the subject of physical education and health (PEH) at three upper secondary schools in Sweden. The purpose of the study is to investigate how assessment for learning is realised in PEH and what triadic relations between the teacher, student and subject content are established in the formative assessment practice. The empirical material consists of group reflections within a Teacher Learning Community (TLC) as well as field studies, including lesson observations and semi structured interviews with both students and teachers. In the first step of the analysis the material is categorized by means of the five key strategies (Wiliam, 2010a), in order to identify different ways of working with AfL in upper secondary PEH. The second step is a combination of a governmentality (Foucault, 1978/1991b), a performativity (Ball, 2003) and a didactic (Hudson, 2002) analysis, which illuminates what triadic relations are established under different conditions of governance. The findings highlight five fabrications of AfL in PEH, named after their most prominent features or functions, AfL as: i) Empowerment, ii) Physical Activation, iii) Grade Generation, iv) Constructive Alignment, v) Negotiation. ”Among the products of discursive practices are the very persons who engage in them” (Davies & Harré, 2001, p. 263). Accordingly, different teacher and student subjects as well as characteristics of the subject content are constituted in each of these fabrications. Moreover, the so called ‘backwash effect’ (Torrance, 2012) implies that the contrasting versions of AfL promote different kinds of learning, such as: i) increased autonomy, ii) participation in a community of practice, iii) criteria compliance, iv) acquisition of prescribed abilities, v) group development. However, the big idea of AfL is to adapt the teaching to the students and not the students to the knowledge requirements. Hence, this dissertation could serve as a basis for discussion on possible didactic implications of AfL in PEH.
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Baron, Emma. "Characterization of the t(6;11)(q27;q23) in pediatric acute myeloid leukemia." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427499.
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Acute myeloid leukemia (AML) set up for the 10 % of pediatric leukemias. Patient genetic background has been demonstrated to be the most important feature for a correct management of patient diagnosis and prognosis. To date just 40 % of AML shows typical molecular markers with clinical impact, thus for the most of them new genetic alterations might be evaluated in order to achieve a better patients stratification and a deeper understanding of leukemogenesis.
In the AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) LAM-2002/01 treatment protocol, children affected by acute myeloid leukemia (AML) were stratified by using a risk group classification based on a combination of specific genetic abnormalities and response to treatment. Samples from 741 AML patients collected from 2000 to 2008 were investigated for their biological and clinical significance. MLL rearrangements were identified in 77/741 patients (10.4 %), with significantly different clinical outcomes depending on the MLL translocation partner. GEP analysis defined significant gene expression signatures dependent on the MLL-partner gene. Array-CGH analysis established high levels of DNA amplification (75 %) with respect to deletions (25 %) for MLL-AML, and the del(12p) to be considered as a novel feature for leukemia stratification.
The t(6;11)(q27;q23) translocation is characterized by MLL-AF6 expression, a bad prognostic marker in AML; however, the exact tumorigenic mechanism is still unclear. Patients with MLL-AF6 displayed an adverse outcome, a specific GEP signature, as well as the highest DNA imbalances with additional recurrent genomic rearrangements in 12p, 11q and 6q. AF6 gene has no similarities with other MLL-partner genes and encodes for a cytoplasmatic protein involved in signal transduction. The chimeric protein, instead, has a nuclear localization, where it can homodimerize to activate transcription. The RAS pathway is often implicated in MLL-leukemia and AF6 was shown to inhibit RAS signaling in epithelial cells. Here, by immunofluorescence and immunoprecipitation analyses, the AF6-RAS interaction was demonstrated in bone marrow cells of healthy donors, while in t(6;11)(q27;q23) leukemic cell lines AF6 protein resulted sequestrated into the nucleus. Silencing for AF6 gene in healthy samples caused the overexpression of the RAF/MEK/ERK pathway proteins, confirming the RAS-inhibiting role of AF6 in hematopoietic cells. Specific silencing of MLL-AF6 in leukemic cells resulted in AF6 liberation into cytoplasm, where it colocalized with RAS effecting its downstream targets. By reverse phase protein array, cytoplasmic AF6 restoration was shown to improve expression of pro-apoptotic proteins PARP and CASPASE7 in leukemic cells and to diminish levels of P-CREB, mTOR, P-JAK and CYCLINs, involved in cell proliferation. As a result, reduced cell colony formation in semisolid medium was observed, accompanied with an augmented percentage of cell mortality. The same effects were obtained with two specific MEK inhibitors, confirming the RAS pathway implication in MLL-AF6-leukemia. These results suggest a possible mechanism by which MLL-AF6 acts in AML: the loss of RAS-inhibition by AF6 nuclear sequestration could be responsible for the proliferation advantage to t(6;11)(q27;q23) cells, enhancing the effect of the chimera in AML development.Le leucemie acute mieloidi (LAM) costituiscono il 10 % delle leucemie pediatriche e l'assetto genetico del paziente è oggigiorno alla base della scelta del percorso terapeutico più adatto, rivestendo un ruolo fondamentale durante la fase diagnostica. Poiché attualmente circa il 40 % dei pazienti LAM presenta un marcatore molecolare riconoscibile, la ricerca in questo campo è tesa verso la scoperta di nuove anomalie che permettano una migliore classificazione dei pazienti e una più profonda comprensione del processo di leucemogenesi. Secondo il protocollo di trattamento LAM-2002/01 dell’AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica), i bambini affetti da leucemia acuta mieloide (LAM) sono stati stratificati in classi di rischio in base a una combinazione di specifiche anomalie genetiche e risposta al trattamento. I campioni prelevati da 741 pazienti LAM raccolti nel periodo 2000-2008 sono stati studiati per il loro significato biologico e clinico. Riarrangiamenti del gene MLL sono stati identificati in 77/741 pazienti (10.4 %), con risultati clinici molto diversi a seconda del partner di traslocazione di MLL. Un’analisi di GEP ha definito significativi pattern di espressione genica dipendenti dal gene partner di MLL. Mediante un’analisi di Array-CGH è stato stabilito che le LAM caratterizzate da riarrangiamenti del gene MLL si riscontra una maggior quantità di amplificazioni del DNA (75 %) rispetto alle delezioni (25 %) e che la delezione del(12p) può essere considerata una nuova caratteristica per la stratificazione delle leucemie. La traslocazione t(6;11)(q27;q23) è caratterizzata dall’espressione di MLL-AF6, un marcatore di cattiva prognosi nella LAM, sebbene l'esatto meccanismo oncogeno non sia ancora chiaro. I pazienti MLL-AF6 mostrano un esito particolarmente sfavorevole, uno specifico profilo di espressione genica, così come il più alto numero di sbilanciamenti cromosomici con riarrangiamenti genomici aggiuntivi ricorrenti in 12p, 11q e 6q. Il gene AF6 non ha analogie con altri geni partner di MLL e codifica per una proteina citoplasmatica coinvolta nella trasduzione del segnale. La proteina chimerica, invece, ha una localizzazione nucleare, dove può omodimerizzare per attivare la trascrizione. Il pathway di RAS è spesso implicato nelle leucemie caratterizzate da MLL ed è stato dimostrato che AF6 è in grado di inibire la trasmissione del segnale a valle di RAS in cellule epiteliali. In questo studio, mediante analisi di immunofluorescenza e immunoprecipitazione, l'interazione AF6-RAS è stata dimostrata in cellule di midollo osseo di donatori sani, mentre in linee cellulari leucemiche con la traslocazione t(6;11)(q27;q23) la proteina AF6 è sequestrata nel nucleo. Il silenziamento del gene AF6 in campioni sani ha causato la sovraespressione delle proteine del pathway RAF/MEK/ERK, confermando il ruolo inibitorio di AF6 su RAS nelle cellule ematopoietiche. Il silenziamento specifico di MLL-AF6 in cellule leucemiche ha comportato la liberazione di AF6 nel citoplasma, dove colocalizza con RAS con un effetto sui suoi effettori a valle. Mediante la tecnica del reverse phase protein array è stato visto che il ritorno di AF6 nel citoplasma in cellule leucemiche ha portato all’aumento dell'espressione delle proteine pro-apoptotiche PARP e CASPASI7 e alla diminuzione dei livelli di P-CREB, mTOR, P-JAK e CICLINE, coinvolte nella proliferazione cellulare. Di conseguenza, è stata osservata una ridotta formazione di colonie in terreno semisolido, accompagnata da una aumentata percentuale di mortalità cellulare. Gli stessi effetti sono stati ottenuti con due inibitori specifici di MEK, confermando l'implicazione del pathway di RAS nella leucemia MLL-AF6. Questi risultati suggeriscono un possibile meccanismo attraverso il quale MLL-AF6 agisce nella LAM: la perdita di inibizione di RAS tramite il sequestro nucleare di AF6 potrebbe essere responsabile del vantaggio proliferativo delle cellule t(6;11)(q27;q23), aumentando l'effetto della chimera nello sviluppo della LAM.
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Kábrtová, Denisa. "Studium vlastností synteticky připraveného thaumasitu." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2018. http://www.nusl.cz/ntk/nusl-372197.
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The thesis is focused on the optimization of the thaumasite preparation in the way of ternesite hydration and further comparison of this approach to the other methods. The thaumasite was prepared by three different methods for this purpose - according to Aguilera et al., Purnell and the hydration method of ternesite clinkers. Finally, the X-ray diffraction analysis was particularly used to evaluate the obtained properties and results.
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Kolaja, Filip. "Sledování termodynamické stability ettringitu v závislosti na zvolených vnitřních a vnějších parametrech." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-392342.
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This diploma thesis is focused on long term monitoring of thermodynamic stability of ettringite under selected conditions and its possible destabilization or transformation into another AFt phase, especially thaumasite. Ettringite samples were made in two ways, by hydrating the yeelimite in the system with the alite and by addition of aluminium sulphate and calcium hydroxide.
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Dourado, Keina Maciiele Campos. "Papel da Endoglina/CD105 em leucemias agudas: um potencial alvo para intervenção terapêutica." Universidade Federal da Bahia, 2016. http://repositorio.ufba.br/ri/handle/ri/21386.
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O tratamento das leucemias agudas continua sendo um grande desafio clínico devido, principalmente à heterogeneidade e alta toxicidade da terapia padrão utilizada. Dessa forma, novos alvos terapêuticos são urgentemente necessários e os anticorpos monoclonais tem surgido como uma das opções terapêuticas mais promissoras. A endoglina, também conhecida como CD105, é um receptor da superfamília do TGF-β, expresso nas células-tronco hematopoiéticas (HSC) de todos os sítios hematopoiéticos, incluindo a medula óssea, onde é descrita como um marcador para HSC de longo prazo. Apesar da expressão de CD105 ter sido relacionada a diversos tipos de tumores sólidos, principalmente devido ao papel desse receptor na angiogênese, relativamente pouco é conhecido em relação a expressão de CD105 e a sua função em neoplasias hematopoiéticas. Este estudo revelou alta expressão de endoglin na maioria dos blastos de pacientes com leucemia mieloide aguda (LMA) e leucemia linfoblástica aguda (LLA). Utilizando um modelo de xenotransplante, verificamos que as blastos CD105+ possuem uma actividade leucemogênica superior em comparação com a população de CD105-. Adicionalmente, investigamos se o bloqueio da endoglina, usando TRC105, poderia resultar em uma opção terapêutica para tratamento das leucemias agudas e descobrimos que na LMA, o TRC105 impediu o engraftment de blastos primários e inibiu a progressão da leucemia após o estabelecimento da doença, mas na LLA, o TRC105 sozinho foi ineficaz devido à uma maior secreção da forma soluvél da endoglina (sENG). No entanto, tanto na LLA quanto na LMA, TRC105 potencializou o efeito terapeutico da quimioterapia padrão e inibiu a progressão da doença, indicando que TRC105 pode representar uma nova opção terapêutica para LLA e LMA.
Successful treatment of acute leukemia remains a clinical challenge due to the toxicity and the relatively poor responses to the current standard therapy. Thus, treatments that address novel therapeutic targets are urgently needed and, for this purpose, monoclonal antibodies have been one of the most promising strategy once they are able to deliver their therapeutic effects with minimal toxicity. Endoglin, also known as CD105, is a receptor of the transforming growth factor-beta (TGF-β) superfamily that has been found expressed in hematopoietic stem cells (HSCs) from all hematopoietic sites, including the bone marrow, in which it is described as a marker for long-term HSC. CD105 is also found to be expressed in several cancers. However, because CD105 expression has been studied mostly in the context of solid tumors and angiogenesis, relatively little is known about CD105 expression and role in hematopoietic malignancies. We identified endoglin expression on the majority of blasts from patients with acute myeloid leukemia (AML) and acute B-lymphoblastic leukemia (B-ALL). Using a xenograft model, we find that CD105+ blasts are endowed with superior leukemogenic activity compared to the CD105- population. We test the effect of targeting this receptor using the monoclonal antibody TRC105, and find that in AML, TRC105 prevented the engraftment of primary AML blasts and inhibited leukemia progression following disease establishment, but in B-ALL, TRC105 alone was ineffective due to the shedding of soluble CD105. However, in both B-ALL and AML, TRC105 synergized with reduced intensity myeloablation to inhibit leukemogenesis, indicating that TRC105 may represent a novel therapeutic option for B-ALL and AML.
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Pospíšilová, Klára. "Studium vlastností thaumasitu v dlouhodobém horizontu." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2018. http://www.nusl.cz/ntk/nusl-372084.
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This thesis deals with monitoring the thermodynamic stability of thaumasite and monitoring it is properties in the long term. The aim was to synthesize thaumasite under different conditions and to evaluate it using X-ray diffraction analysis and thermal analysis.
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Todd, Matthew Andrew Melville. "Characterizing the Cellular Role of PHF6." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32337.
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Defective chromatin remodeling proteins are associated with both germline and acquired human disease. PHF6 is encoded by an X-linked gene that is predominantly expressed in the brain and thymus. Structurally, PHF6 contains nuclear and nucleolar localization sequences as well as two ZaP domains, which bind dsDNA. Germline mutations in PHF6 are the cause of BFLS, an XLID, while somatic PHF6 mutations have been identified in T-ALL, AML, and CML. Indeed, screening of a pediatric cohort of nine T-ALL patients revealed a novel H329Q mutation. In a further clinical analysis, T-ALL onset occurred in a 9-year old male BFLS patient with an R342X mutation, suggesting that BFLS might be a cancer predisposition syndrome. To better understand its protein function, recombinant PHF6 was co-immunoprecipitated for a mass spectrometry based proteomic screen. Notably, PHF6 co-purified with multiple constituents of the NuRD complex, an important transcriptional regulator during embryogenesis and lineage commitment with particularly well characterized responsibilities during lymphogenesis. PHF6-NuRD localization was restricted to the nucleoplasm, however PHF6 also co-purified with several ribosomal and splicing proteins. When examined further, PHF6 was found to be recruited to the nucleolus by an RNA-mediated interaction and co-localized within the subnucleolar FC and DFC compartments. ChIP-qPCR revealed that PHF6 binds to transcribed regions of rDNA, resulting in the repression of rRNA. These data thus present a model of PHF6 acting as a tumour suppressor by mediating both nucleoplasmic and nucleolar transcriptional events.
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Křižanová, Lucie. "Studium vlastností ettringitu v dlouhodobém horizontu." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2018. http://www.nusl.cz/ntk/nusl-372149.
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This thesis is focused on monitoring attributes of ettringite in long term horizon, especially on his thermodynamic stability. Ettringit was prepared in two ways. Firstly, it is a method of hydration of yeelimite, secondly, ettringit is prepared by addition of aluminium sulphate and calcium hydroxide.
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Dogan, Sahin. "2000-talets byggindustri; olyckor och orsaker." Thesis, Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-19831.
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Arbetsmiljöproblem på byggarbetarplatser är idag väldigt omfattande och omtalat. Byggindustrin är nämligen en av landets farligaste industrier. Byggindustrin sysselsätter ca 290 000 (2009) och omsätter ca 250 miljarder SEK. Denna rapport utreder bristerna inom arbetsmiljön och orsakerna bakom dödsolyckorna. Studien omfattar granskning och analysering av arbetsmiljöverkets utredningar och intervjuer. Den omfattar även granskning av arbetsmiljöansvaret och vad aktörerna har för ansvar och funktioner i arbetsmiljöarbetet. Resultatet visar att byggarbetarplatser är bland landets farligaste arbetsplatser. Statistiken speglar inte verkligheten och viktiga faktorer utesluts. Arbete från höjd och med verktyg och maskiner är de farligaste typerna av arbeten. Den vanligaste dödsolyckan är fall från höjd. Den vanligaste orsaken till dödsolyckorna är organisatoriska. Arbetsmiljöansvaret är tydligt; arbetsgivaren bär huvudansvaret för arbetsmiljön. Arbetsmiljölagen ligger till grund för riktlinjer som arbetsmiljöverket ger ut. Att bryta mot en lag eller en föreskrift får idag inte så allvarliga konsekvenser utan är en längre process innan straff utdelas. Brister i arbetsmiljö är mer omfattande i små företag och mänskliga faktorn är ofta en av de största bidragande faktorerna. Att skärpa lagen och ge inspektörerna mer behörigheter än vad de nu har kan skapa en bättre arbetsmiljö och en säkrare byggarbetsplats.Work Environment problems at construction worksites are a common topic for discussions. The construction industry is one of the most dangerous industries in Sweden. The industry consists of about 290 000 workers (2009) and the investment was 250 billion SEK. This report will investigate the risks of the work environment and the causes of the fatal accidents. The study includes review and analysis of occupational injury statistics, investigation of the occupational accidents made by the work environment authority and interviews. It also includes review of work responsibilities and what type of responsibilities and functions the participant has in the work environment. The result shows that the construction worksites are one of the most dangerous workplaces. The statistics do not reflect reality and important factors are excluded. Work from height and with using machines and tools are the most hazardous types of work. The most common fatal accident is a fall from height. The most common cause of fatal occupational accidents is organizational. Work responsibilities are clear: the employer has the main responsibility for the work environment. The Work Environment Act is the basis for the regulations that Swedish work environment authorities give out. Breaking the law or regulation may not lead to seriously consequences, because it’s a long process before punishment can be divided. The issues in the work environment are more extensive in small companies and human error is much due to accidents. Enforcing these laws and giving the inspectors more eligibility than they now have will achieve a better working environment and safer construction sites.
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Chisholm, Louise Mairi. "Functional analysis of the AF4/LAF4/FMR2 (ALF) family of transcriptional regulators." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504308.
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Gonzalez‐Estrada, Alexei, Timothy Archibald, Kristen Dinsmore, Greg Mosier, Bethany Campbell, and Stacy D. Brown. "Stability of Diluted Neuromuscular Blocking Agents Utilized in Perioperative Hypersensitivity Evaluation." Digital Commons @ East Tennessee State University, 2018. https://doi.org/10.1111/all.13576.
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Kobitzsch, Benjamin Michael [Verfasser]. "Intragenetische IKZF1-Deletionen bei Erwachsenen mit BCR-ABL-negativer akuter lymphatischer Leukämie (ALL) / Benjamin Michael Kobitzsch." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1179779096/34.
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MISSIROLI, Silvia. "INVOLVEMENT AND ROLE OF THE PI3K/AKT NETWORK IN DIFFERENT TYPES OF LEUKEMIA CELLS BEFORE AND AFTER IN VITRO TREATMENT WITH CONVENTIONAL OR NEWLY DEVELOPED DRUGS." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388718.
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Alterations in the PI3K/Akt network play important roles in the etiology, maintenance and progression of acute leukemia. The analysis of the intracellular signaling profile of leukemia patients could serve to reveal novel molecular targets for treatment of this disease and to identify critical biomarkers for accurate and clinically relevant diagnosis and prognosis. This research is aimed by investigating the signaling PI3K/Akt pathway in acute leukemia cells. In particular, this work aims at investigating enzymatic and genetic alterations of the PI3K/Akt network in AML and ALL. It will be useful for diagnosis, underlying mechanisms of alterations occurring in leukemia development and progression.
The Akt expression levels were very high in acute leukemia patients and cell lines, with very high activation levels, detected by the phosphorylation on the serine 473 residue, in ALL cells. Powerful activation of Akt and some main downstream targets can be observed in ALL cell lines. Moreover, it is known that the bad prognosis of some patients depends on the activation of some signaling pathways, and a bad prognosis is associated to patients that have higher activation of Akt (Kornblau et al 2006).
The administration of drugs directly acting on PI3K and Akt (Perifosine, ErPC and PI3K/Erk inhibitor) was able to induce a strong reduction of proliferation and induce apoptosis. These drugs occurred via PI3K/Akt, as demonstrated by the weakened phosphorylation levels of the Akt downstream targets GSK3, mTOR and p21, involved in critical cell processes; treatment with Doxorubicin does not inhibits phosphorylation of downstream target and activity of Akt. Sequencing analysis on the AML and ALL cell lines and patients, could contribute to identify the molecular alterations underlying the leukemogenesis. We found one recurrent intronic transition, 2 cell lines out of 6 and all 4 patients, the IVS4a+30g. This mutation may be involved in mechanisms of splicing of Akt. Data on Akt alterations in acute leukemias are scarce in literature, thus, more detailed analyses in a wider group of patients are necessary to confirm the frequency of the identified change and its potential functional meaning.
In this study we also addressed the work on the role of Akt during the initial steps of the human erythroid differentiation. We have shown that EPO treatment activates Akt in K562 erythroleukemia cells and induces the translocation of Akt active form in the nuclear compartment in a rapid and transient manner, suggesting that Akt plays a crucial role in EPO mediated erythroid differentiation.
In vivo Akt phosphorylation and in vitro Akt kinase activity were up-regulated by EPO administration to K562 cells. Both phosphorylation and activity of Akt were down-regulated by the pharmacological PI3K inhibitors, Ly294002 or Wortmannin, thus showing that Akt activation is in
the PI3K signal transduction axis.
Immunoprecipitable nuclear Akt activity was detectable after 10 minutes and showed an increase
that reached a maximum after 15-20 minutes. This enhancement was similar but delayed of 5 to 10
minutes when compared to Akt activation in whole cells and may be explained by the time required
by Akt for translocating into this cell fraction, where almost all Akt results phosphorylated in the
sites of activation.
Although it is now clear that Akt migrates to the nucleus as the result of treatment with growth
factors, thus, Akt nuclear translocation may be attributable to an activation of PI3K. It is worthy to
note that, when nuclear Akt kinase activity is inhibited erythroid maturation is not taking place.
This work provided evidences for the up-regulation of the PI3K/Akt axis in acute leukemias, and in
particular in ALL type. Important step in this field will be the identification of the molecular events
produced by Akt activation during erythroleukemia cells differentiation.
These findings may help identifying novel target into the nucleus essential for differentiation and
thus useful for anticancer therapy of hematological malignancies.
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Hrdina, Matěj. "Ověření možnosti syntetické přípravy ettringitu a thaumasitu." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2015. http://www.nusl.cz/ntk/nusl-227221.
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The work is focused on the possibilities of using FBC fly ash for composite cements, monitoring their hydration processes, especially the creation of AFt phase. The possibility of preparing synthetic ettringite and thaumasite and their detection.
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RICCIUTI, Manola. "Sviluppo di metodi senza contatto per il monitoraggio di parametri fisiologici e attività nell'ambito dell'Ambient Assisted Living." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/290834.
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Uno degli ambiti di maggior interesse in questi ultimi anni all'interno del quale molti progetti vengono sviluppati, è l'Ambient Assisted Living (AAL). L'obbiettivo di questa tesi si colloca in quest'area, tramite lo sviluppo di soluzioni per il monitoraggio di attività della vita quotidiana e parametri fisiologici sfruttando tecnologie senza contatto. I soggetti a cui è rivolta l'attenzione primaria degli studi presentati, sono individui anziani o fragili che hanno un costante bisogno di osservazione in ambiente domestico, preservandone l'autonomia. L’indipendenza per soggetti affetti da disordini motori o neuronali è un fattore determinante e consente, da un punto di vista socio-economico, un risparmio di risorse il cui costo graverebbe sul sistema sanitario dell'intera nazione. Negli ultimi anni c’è stato un grande sforzo da parte della comunità scientifica per poter affrontare questi problemi attraverso tecnologie dedicate, direttamente installate all’interno di case “intelligenti” (smart home). Questa tesi si focalizza sullo sviluppo di algoritmi e soluzioni per ambienti intelligenti sfruttando sensori RGB e di profondità. Si cerca soprattutto di fornire soluzioni non invadenti, confortevoli e allo stesso tempo atte a garantire la privacy. Verranno descritti metodi improntati al monitoraggio e automatizzazione del controllo della corretta nutrizione basati sulle reti neurali, tecniche di rilevamento e classificazione delle cadute per le quali vengono elaborate immagini di profondità, stima del battito cardiaco da immagini RGB attraverso algoritmi di riconoscimento del volto, della pelle, dell'amplificazione del colore e delle componenti principali passando attraverso spazi di colore differenti. Infine, con lo scopo di osservare problematiche legate al sistema nervoso centrale, verrà presentato un approccio di estrazione della variazione del diametro della pupilla nel tempo basato sullo sviluppo di tecniche di segmentazione e riconoscimento dei bordi.One of the most interesting aspects in recent years thanks to which many projects have been developed, is Ambient Assisted Living (AAL). The aim of this thesis relies on this area, through the development of solutions for the monitoring of Activities of Daily Fiving (ADL) and physiological parameters using non-contact technologies. The subjects to whom the primary attention of the presented studies are addressed are elderly or frail individuals who have a constant need for observation and monitoring in their home environment, trying to preserve their autonomy. Independence for people suffering from motor or neuronal disorders is a determining factor and allows, from a socio-economic point of view, a saving of resources whose cost would weigh on the health system of the entire nation. In recent years there has been a great effort by the scientific community to be able to solve these problems through dedicated technologies, directly installed inside what are defined as ``smart homes". This work focuses on the development of algorithms and solutions for intelligent environments using RGB and depth sensors. Above all, we try to provide solutions that are not intrusive, comfortable and at the same time able to guarantee privacy. Methods aimed at monitoring and automating the control of correct nutrition based on neural networks, techniques for detecting and classifying falls for which depth images are processed, heart rate estimation from RGB images through face and skin recognition algorithms will be described, in which the main employed technique are the amplification of the skin color and the principal components analyses passing through different color spaces. Finally, with the aim of monitoring problems related to the central nervous system, an approach to extract the variation of the pupil diameter over time based on the development of segmentation and edge recognition techniques will be presented.
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Licon, Tricia Rachelle. "A program evaluation of the adolescent family life program." CSUSB ScholarWorks, 2001. https://scholarworks.lib.csusb.edu/etd-project/1958.
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The focus of the study was an evaluation of a pregnancy prevention program. The study was designed to look at the adolescent pregnant and parenting population in the Adolescent Family Life Program, which serves about 300 clients in Southern California.
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Castillo, Ober, Simy Sotomayor, Guillermo Kemper, and Vincent Clement. "Correspondence Between TOVA Test Results and Characteristics of EEG Signals Acquired Through the Muse Sensor in Positions AF7–AF8." Smart Innovation, Systems and Technologies, 2021. http://hdl.handle.net/10757/653803.
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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.This paper seeks to study the correspondence between the results of the test of variable of attention (TOVA) and the signals acquired by the Muse electroencephalogram (EEG) in the positions AF7 and AF8 of the cerebral cortex. There are a variety of research papers that estimates an index of attention in which the different characteristics in discrete signals of the brain activity were used. However, many of these results were obtained without contrasting them with standardized tests. Due to this fact, in the present work, the results will be compared with the score of the TOVA, which aims to identify an attention disorder in a person. The indicators obtained from the test are the response time variability, the average response time, and the d′ prime score. During the test, the characteristics of the EEG signals in the alpha, beta, theta, and gamma subbands such as the energy, average power, and standard deviation were extracted. For this purpose, the acquired signals are filtered to reduce the effect of the movement of the muscles near the cerebral cortex and then went through a subband decomposition process by applying transformed wavelet packets. The results show a well-marked correspondence between the parameters of the EEG signal of the indicated subbands and the visual attention indicators provided by TOVA. This correspondence was measured through Pearson’s correlation coefficient which had an average result of 0.8.
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