Journal articles: 'AETD'

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Kim, Hyung-Jin, Seon Il Jang, Young-Jun Kim, Hyun-Ock Pae, Hae-Young Won, Kyung-Hwan Hong, Hyuncheol Oh, Tae-Oh Kwon, and Hun-Taeg Chung. "4-Acetyl-12,13-Epoxyl-9-Trichothecene-3,15-Diol from Isaria japonica Mediates Apoptosis of Rat Bladder Carcinoma NBT-II Cells by Decreasing Anti-apoptotic Bcl-2 Expression and Increasing Pro-apoptotic Bax Expression." American Journal of Chinese Medicine 32, no. 03 (January 2004): 377–87. http://dx.doi.org/10.1142/s0192415x0400203x.

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We studied the effect of 4-acetyl-12,13-epoxyl-9-trichothecene-3,15-diol (AETD) isolated from Isaria japonica, one of the most popular Chinese fungal medicines, on the induction of apoptosis in rat bladder carcinoma NBT-II cells. AETD was cytotoxic to NBT-II cells, and this cytotoxic effect appears to be attributed to its induction of apoptotic cell death, as AETD induced nuclear morphological changes and internucleosomal DNA fragmentation, and increased the proportion of hypodiploid cells and activity of caspase-3. AETD treatment also decreased the expression of the anti-apoptotic protein Bcl-2 and increased the expression of the pro-apoptotic protein Bax. These results provide important information in understanding the mechanism(s) of AETD-induced apoptosis.

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Radovanović, Milan, Marija Petrović Mihajlović, and Milan Antonijević. "2-Amino-5-ethyl-1,3,4-thiadiazole as inhibitor of brass corrosion in 3% NaCl." Metallurgical and Materials Engineering 22, no. 1 (March 31, 2016): 51–60. http://dx.doi.org/10.30544/140.

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The electrochemical behaviour of brass and anticorrosion effect of 2-amino-5- ethyl-1,3,4-thiadiazole (AETD) in chloride solution was investigated using electrochemical techniques. Results show that inhibition efficiency depended on inhibitor concentration and immersion time of brass electrode in inhibitor solution. Mechanism of brass corrosion inhibition by 2-amino-5-ethyl-1,3,4-thiadiazole includes adsorption of inhibitor on active sites on electrode surface. Adsorption of AETD in 3% NaCl solution obeys Langmuir adsorption isotherm.

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Chanasyk, David S., Emmanuel Mapfumo, and Crystal L. A. Chaikowsky. "Estimating actual evapotranspiration using water budget and soil water reduction methods." Canadian Journal of Soil Science 86, no. 4 (August 1, 2006): 757–66. http://dx.doi.org/10.4141/s05-063.

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Studies on estimation of actual evapotranspiration on disturbed lands are scarce and yet such data are essential in hydrologic modeling. Our study compared the variability of estimates of actual evapotranspiration (AET) from a reclaimed site in northern Alberta using the simplified water budget (WB) and soil water reduction (SWR) methods. The AET estimates from the simplified water budget equation (AET1) required field soil water content, precipitation and runoff. The AET estimates from the soil water reduction method (AET2) required daily potential evapotranspiration (PET), field capacity (FC) water content, minimum field-measured water content, and field water content. Soil water was measured using neutron moisture gauge every 2 wk during the growing season for a 2-yr period. The average AET1 and AET2 estimates for 2001 were 1.9 and 1.4 mm per day, respectively, where as those for 2002 were 2.1 and 1.2 mm per day, respectively. The paired t-tests to compare AET1 against AET2 indicated significance differences (P ≤ 0.05) in 5 out of 11 measurement dates, especially during high rainfall periods. Overall AET2 estimates were more variable than AET1 estimates. Therefore, the larger variability of AET2 estimates imply less reliability of spatially averaged AET2 estimates for use in regional and global circulation models. Key words: Extractable water, reclaimed land, water budget, soil water reduction, potential evapotranspiration

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Singh, Manraj, Amit Kumar, Navreet Kaur, and Shubham Chuchra. "Proposing a New Method for Automatic Environmental Temperature Detection (AETD) by using IOT." International Journal of Computer Applications 121, no. 2 (July 18, 2015): 41–44. http://dx.doi.org/10.5120/21516-4490.

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Shuter, Emily C., Hung Duong, Craig A. Hutton, and Malcolm D. McLeod. "The enantioselective synthesis of APTO and AETD: polyhydroxylated β-amino acid constituents of the microsclerodermin cyclic peptides." Organic & Biomolecular Chemistry 5, no. 19 (2007): 3183. http://dx.doi.org/10.1039/b707891a.

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Davies, Stephen G., Ai M. Fletcher, Emma M. Foster, James A. Lee, Paul M. Roberts, and James E. Thomson. "Asymmetric Syntheses of APTO and AETD: the β-Amino Acid Fragments within Microsclerodermins C, D, and E." Journal of Organic Chemistry 78, no. 6 (February 21, 2013): 2500–2510. http://dx.doi.org/10.1021/jo302731m.

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Khan, Usman, Michael Abunassar, Avijit Chatterjee, and Paul D. James. "Advanced Endoscopy Trainee Involvement Early in EUS Training May Be Associated with an Increased Risk of Adverse Events." Journal of the Canadian Association of Gastroenterology 3, no. 2 (December 12, 2018): 83–90. http://dx.doi.org/10.1093/jcag/gwy066.

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Abstract Background The quality of endoscopic ultrasound (EUS) involving advanced endoscopy trainees (AETs) is not well understood. In this study, we aimed to examine adverse events (AE) risk and diagnostic yield of EUS procedures involving AETs. Methods We conducted a retrospective single-centre review from September 2009 to August 2015. Clinical, procedural, cytological, and hospital visit data within 30 days of the EUS procedure was collected. Primary outcomes were occurrence of an AE and a diagnostic specimen on cytopathology. Each AE was classified as “definitely related,” “possibly related,” or “not related” to the EUS procedure based on a previously defined consensus approach. Advanced endoscopy trainee involvement was established through the operative report. Results Our study included 1657 EUS procedures, of which 27% (451 of 1657) involved AETs. Endoscopic ultrasound was most commonly performed to evaluate pancreatic pathology (46% of cases). Overall AE incidence was 3.4%; it was 4.9% when an AET was involved and 2.8% when the EUS was performed without an AET (P = 0.04). The risk of an AE when AETs were involved was greatest in the first three months of training (7.9% versus 2.7%, P = 0.04). Multivariate analysis limited to the first three months of training demonstrated AET involvement to be associated with an increased AE risk after adjusting for patient and procedural factors (adjusted OR 3.2; 95% CI, 1.1–8.7; P = 0.03). The overall diagnostic yield was 76%. This was not compromised by AET involvement for any quartile of training. Conclusions We observed an increased risk of EUS-related AEs when procedures involved AETs during the first three months of training.

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Padgett, D. A., and R. M. Loria. "In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol." Journal of Immunology 153, no. 4 (August 15, 1994): 1544–52. http://dx.doi.org/10.4049/jimmunol.153.4.1544.

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Abstract Dehydroepiandrosterone (5-androstene-3 beta-ol-17-one, DHEA) has been shown to protect mice from lethal viral and bacterial infections. However, recently, androstenediol (5-androstene-3 beta-17 beta-diol, AED) and androstenetriol (5-androstene-3 beta-7 beta-triol, AET), metabolites of DHEA, have each shown to be more potent endocrine regulators of the immune response. In contrast to glucocorticosteroids, in vivo, these steroid hormones up-regulated the cellular immune response of the host to limit virus-mediated pathology. These experiments first examined the in vitro influences of DHEA, and AED, or AET on mitogen-stimulated activation of murine lymphocytes. From physiologic to pharmacologic doses, DHEA suppressed proliferation of mixed splenocyte cultures activated with Con A or LPS by 20 to 70% whereas AED had little influence on the response. In sharp contrast, AET potentiated the response with both mitogens to 50 to 70% above control. Analogous to these observations was the regulation of IL-2 and IL-3 secretion from Con A-activated lymphocytes by each of these hormones which again was depressed analyzed. The suppressive effects of hydrocortisone on Con A-induced lymphocyte proliferation and cytokine production were strongly counteracted by coculture with AET. DHEA did not counteract hydrocortisone activity whereas AED showed moderate antiglucocorticoid function.

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Shaak, Thomas L., Dayanjan S. Wijesinghe, Charles E. Chalfant, Robert F. Diegelmann, Kevin R. Ward, and Roger M. Loria. "Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors." International Journal of Medicinal Chemistry 2013 (April 4, 2013): 1–8. http://dx.doi.org/10.1155/2013/203606.

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DHEA, 17α-AED, 17β-AED, and 17β-AET exhibit strong biological activity that has been attributed to androgenic, estrogenic, or antiglucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED, and 17β-AET for their ability to activate the human AR, ER, and GR and determine the relative androgenicity, estrogenicity, and glucocorticoid activity. The results show that, at the receptor level, these androstene hormones are weak AR and even weaker ER activators. Direct androstene hormone activation of the human AR, ERα, and ERβ may not be essential for their biological function. Similarly, these hormones indirectly activated the human GR, only in the presence of high dexamethasone concentrations. These results underscore the major difference between androstene hormone interactions with these nuclear receptors and their biological effects.

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Tafla, Bairu. "Register of International Scholars in Ethiopian and Eritrean Studies Supplement 2." Aethiopica 6 (January 20, 2013): 201–2. http://dx.doi.org/10.15460/aethiopica.6.1.379.

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Supplement to the already printed Registers of International Scholars in Ethiopian and Eritrean Studies. The present compilation contains information of mainly scholars who were not included in Aethiopica 3 and 5 (=Aet3 / Aet5) and some who since then changed their addresses and/or projects.

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Awal, Md Rabiul, Muzammil Jusoh, Thennarasan Sabapathy, Muhammad Ramlee Kamarudin, and Rosemizi Abd Rahim. "State-of-the-Art Developments of Acoustic Energy Transfer." International Journal of Antennas and Propagation 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/3072528.

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Acoustic energy transfer (AET) technology has drawn significant industrial attention recently. This paper presents the reviews of the existing AETs sequentially, preferably, from the early stage. From the review, it is evident that, among all the classes of wireless energy transfer, AET is the safest technology to adopt. Thus, it is highly recommended for sensitive area and devices, especially implantable devices. Though, the efficiency for relatively long distances (i.e., >30 mm) is less than that of inductive or capacitive power transfer; however, the trade-off between safety considerations and performances is highly suitable and better than others. From the presented statistics, it is evident that AET is capable of transmitting 1.068 kW and 5.4 W of energy through wall and in-body medium (implants), respectively. Progressively, the AET efficiency can reach up to 88% in extension to 8.6 m separation distance which is even superior to that of inductive and capacitive power transfer.

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Blanco-Hernández, Araceli, Rodolfo García-Contreras, Rosa E. Sánchez-Fernández, Mariana Palma-Tenango, Juan Cibrián-Tovar, Naybi Muñoz-Cazares, R. Marcos Soto-Hernández, Daniel Padilla-Chacón, F. Javier Prado-Galbarro, and Israel Castillo-Juárez. "EVALUACIÓN DE LA ACTIVIDAD ANTIVIRULENCIA DE ACEITES ESENCIALES CONTRA Pseudomonas aeruginosa." Revista Fitotecnia Mexicana 42, no. 3 (September 18, 2019): 215–25. http://dx.doi.org/10.35196/rfm.2019.3.215-225.

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Los aceites esenciales (AE) se han descrito como agentes bactericidas; sin embargo, estudios in vitro indican que algunos de sus constituyentes volátiles a concentraciones subletales pueden inhibir o promover los sistemas de percepción de quórum (PQ) en Pseudomonas aeruginosa. Es necesario explorar el papel que pueden tener las mezclas de volátiles sobre la virulencia y el establecimiento de la bacteria en sistemas in vivo. Este estudio se llevó a cabo para evaluar las propiedades bactericidas y antivirulencia de AE obtenidos de Thymus vulgaris L., Cymbopogon citratus (DC.) Stapf y Tagetes lucida (Cav) contra P. aeruginosa. La actividad antivirulencia se evaluó mediante la inhibición de factores regulados por PQ, como son la producción de piocianina y la actividad de proteasa y elastasa; además, se determinó la composición de volátiles y su capacidad para evitar el establecimiento de la infección en un modelo de lesión en ratones. Los ensayos in vitro mostraron que el AE de T. vulgaris (AETV) únicamente exhibió actividad bactericida y el AE de T. lucida (AETL) redujo la producción de piocianina en 58 % a concentración subletal de 200 μg mL-1. Para el caso del AE de C. citratus no se registró un efecto bactericida a la máxima concentración evaluada (1000 μg mL-1), aunque redujo ligeramente la producción de piocianina (30 %). En los estudios in vivo únicamente el AETL y el Neosporin® (control positivo) interfirieron en el establecimiento de la bacteria, mientras que el AETV, contrario a lo esperado, lo favoreció, principalmente en zonas adyacentes a las lesiones. Se observó una correlación positiva entre el establecimiento de la bacteria y el número de constituyentes presentes en los AE. Estos resultados apoyan el uso de los AE evaluados para combatir P. aeruginosa y su posible aplicación en terapias antivirulencia.

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Moscetti, Luca, Claudia Omarini, Isabella Sperduti, Fabio Canino, Monica Barbolini, Cecilia Nasso, Angela Toss, Massimo Dominici, and Federico Piacentini. "Thromboembolism (TE) and adjuvant endocrine therapy (AET) in hormone receptor positive (HR+) early breast cancer (EBC): Did the evolution of treatment change the incidence of the adverse event? A metanalysis." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e12516-e12516. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12516.

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e12516 Background: The AET of HR+ EBC has been changing in the recent years. Aromatase inhibitors (AI) as upfront, or in a planned switch strategy after Tamoxifen (T), have been added to the choice of T alone. An increased risk of TE is well known in the T treated patients while AIs have showed a reduced rate of TE. Recently, adding the cyclin dependent kinase 4/6 inhibitors (CDK4/6) abemaciclib to AIs, has showed a positive impact in the high risk HR+ EBC subgroups, but we are seeing an increase of the TE rate. We conducted this meta-analysis to evaluate the impact of the new AETs on the incidence of TE if compared to the standard monotherapy. Methods: We performed a meta-analysis of the randomized phase III trials comparing the experimental AETs and the endocrine standard therapy. A random-effect model to find differences in the rate of TE events between the experimental treatments and the standard therapy has been used. Results: Twelve phase III trials were included. Five trials evaluated the upfront strategy, 6 studies the switch and one the combination with a CDK4/6inhibitor (i.e. abemaciclib). Overall, the new AETs did not significantly modify or affect the rate of TE events (OR 0.708, 0.444-1.130, p = 0.148) with high heterogeneity among studies (I2 87, p < 0.0001). Excluding the abemaciclib trial, the incidence of TE is reduced (OR 0.609, 0.462-0.802, p < 0.0001) with a moderate heterogeneity among the studies (I2 59, p < 0.006). Considering the upfront strategies with AIs, the TE events are reduced (OR 0.507, 0.394-0.651, p < 0.0001) but they are not if we consider the trials in which T is used upfront before AIs (OR 0.762, 0.546-1.065, p = 0.112). Conclusions: Overall, the new treatments (AIs alone or plus CDK4/6 inhibitors) did not affect the rate in TE events. AIs as upfront strategy is the safest AETs of HR+ EBC, being associated to the lowest incidence of TE. The switch strategy increases the TE rate whereas the addition of abemaciclib to the standard AET showed to significantly increase the TE events. The results of the currently ongoing trials with the CDK4/6 inhibitors will help to obtain additional data to evaluate any differences among the different CDK4/6 inhibitors and to clarify the weight of the TE adverse events in the balance of benefit/risk of this new adjuvant strategy.

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Suresh, Chandrababu, Karuppasamy Govindasamy, Saran KS, Mithin Anand, Dilpreet Kaur, John Bosco Anitha, Ali Aloui, Hiba Boughanmi, and Imen Achouri. "Role of aerobics exercise and kettlebell training improving on selected health related physical fitness parameters in obese male adults." Health, sport, rehabilitation 8, no. 4 (December 15, 2022): 8–19. http://dx.doi.org/10.34142/hsr.2022.08.04.01.

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Background: Aerobics exercise training and kettlebell training is recommended to prevent and control overweight/obesity. Purpose: The aim of the this research is to assess the improvement in various variables related to health fitness among obese adults on administrating a twelve weeks aerobics exercise training and kettlebell training. Materials and Methods: Total sixty male adults with obese (Mean ± SD; age: 18.92 ± 1.54 yrs.; height: 172.4 ± 5.4 cm.; weight: 84.4 ± 6.3 kg) were randomly allocated into three equal (n = 20) groups: Aerobic Exercise Training (AET), Kettlebell Training (KBT) and a control group. The AET & KBT training protocol was performed three days per week for 12 weeks. All the selected variables of physical fitness has been examined at baseline and 12 weeks. Control group does not perform any exercise. Analysis and findings: There were significant difference in terms of Flexibility (F), Muscular Endurance (ME), Muscular Strength (MS) and Cardiovascular Endurance (CE), between the AETG & KBTG have been compared with control group (p < 0.05). Body Composition (BF) significant reductions in AET & KBT groups have been compared with control group (p < 0.05). Conclusion: Our findings suggest that AET & KBT protocols have greater effects than control group on health related physical fitness variables in obese male adult individuals. It is recommended that schools and colleges should administrate the aerobic exercise session and kettlebell training among adults for better health perspectives.

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Stepanova, L. N., S. I. Kabanov, and V. V. Chernova. "Locating Acoustic Emission Signals Due to Shock Impacts on a Carbon Fiber Sample Using Piezoelectric and Fiber Optic Sensors." Russian Journal of Nondestructive Testing 58, no. 4 (April 2022): 237–47. http://dx.doi.org/10.1134/s106183092204009x.

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Abstract Comparative tests related to locating acoustic emission (AE) signals due to shock impacts on a T700 carbon fiber sample were carried out. Piezoelectric acoustic emission transducers (AETs) and fiber-optic sensors (FOSs) were installed on the sample, forming rectangular location antennas measuring $$360 \times 280$$ mm. Strikes were delivered with balls weighing 10 and 18.5 g. Antennas consisting of four AET sensors and four FOS sensors and an antenna consisting of two AET sensors and two FOS sensors were organized. When using the antenna containing four FOS sensors, the impact on the sample was produced by a load weighing 530 g dropped from a height of 400 mm. AE signals were recorded by the SCAD-16.10 system with “floating” selection thresholds when the ball was dropped and during its repeated bounces. Then AE signal clusters were formed and recorded during the impact of loads. The arrival times of AE signals to the antenna sensors were calculated using the threshold method, the root mean square (RMS) deviation method and the two-interval method. It is shown that the maximum error in locating AE signals is observed when a steel ball with a diameter of 16 mm is dropped from a height of 300 mm and the minimum error is when using an electronic simulator.

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Taniguchi, Masami, Chihiro Mitsui, Hiroaki Hayashi, Emiko Ono, Keiichi Kajiwara, Haruhisa Mita, Kentaro Watai, et al. "Aspirin-exacerbated respiratory disease (AERD): Current understanding of AERD." Allergology International 68, no. 3 (July 2019): 289–95. http://dx.doi.org/10.1016/j.alit.2019.05.001.

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Bosso, John V. "AERD: Quo Vadis?" World Journal of Otorhinolaryngology - Head and Neck Surgery 6, no. 4 (December 2020): 201–2. http://dx.doi.org/10.1016/j.wjorl.2020.05.011.

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Brett, Jo, Nick J. Hulbert-Williams, Deborah Fenlon, Mary Boulton, Fiona M. Walter, Peter Donnelly, Bernadette Lavery, et al. "Psychometric properties of the Beliefs about Medicine Questionnaire–adjuvant endocrine therapy (BMQ-AET) for women taking AETs following early-stage breast cancer." Health Psychology Open 4, no. 2 (July 2017): 205510291774046. http://dx.doi.org/10.1177/2055102917740469.

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Rozsasi, Ajnacska, Akos Heinemann, and Tilman Keck. "Release of Cyclooxygenase-2 and Lipoxin A4 from Blood Leukocytes in Aspirin-exacerbated Respiratory Disease." Allergy & Rhinology 7, no. 3 (January 2016): ar.2016.7.0172. http://dx.doi.org/10.2500/ar.2016.7.0172.

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Background The release of cyclooxygenase-2 (COX-2) and lipoxin A4 (LXA4) from blood mononuclear cells in patients with aspirin-exacerbated respiratory disease (AERD) is only partially understood. Objective To investigate the presence of COX-2 and LXA4 in peripheral blood mononuclear cells (PBMC) derived from patients with AERD and with nasal polyps (NP) (designated as the AERD-NP group), patients with NP without AERD (the NP group), and healthy controls without sinus disease (the control group). Methods Blood was taken from 14 patients in the AERD-NP group, 6 patients in the NP group, and 8 healthy subjects in the control group. After culturing of human PBMC, the presence of COX-2 protein and LXA4 (ELISA) was detected in the supernatant, and the results were compared among the groups. Results COX-2 and LXA4 were detectable after culturing of PBMC in all patients in the AERD-NP and NP groups and in the control subjects. COX-2 was highest in the patients in the AERD-NP group, but the difference was not significant compared with patients with non-AERD polyp and with the control subjects. LXA4 was also highest in the AERD-NP group, but the difference was also not significant compared with the patients who were non-AERD polyp and the control subjects. Conclusion Neither the release of COX-2 or LXA4 was different between the patients with AERD and with NPs, the patients without AERD and with NPs, and the healthy control group. The release of these proteins in AERD needs further investigation.

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Marler, Thomas E. "The Aeta – Pinatubo Loop." Communicative & Integrative Biology 4, no. 6 (November 2011): 788–90. http://dx.doi.org/10.4161/cib.16973.

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Brantley, F. "North Carolina AEGD model." Journal of Dental Education 55, no. 8 (August 1991): 518–21. http://dx.doi.org/10.1002/j.0022-0337.1991.55.8.tb02555.x.

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Machado-Carvalho, L., R. Torres, M. Perez-Gonzalez, I. Alobid, J. Mullol, L. Pujols, J. Roca-Ferrer, and C. Picado. "Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling." Rhinology journal 54, no. 3 (September 1, 2016): 254–65. http://dx.doi.org/10.4193/rhino15.207.

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Background: Down-regulation of the E-prostanoid (EP)2 receptor has been reported in aspirin exacerbated respiratory disease (AERD). We aimed to evaluate the expression and activation of EP receptors in AERD and their role in prostaglandin (PG) E2 signalling. Methods: Samples were obtained from nasal mucosa of control subjects (NM-C, n=7) and from nasal polyps of AERD patients (NP-AERD, n=7). Expression of EP1-4 was assessed at baseline. Fibroblasts were stimulated with receptor agonists to measure cAMP levels, cell proliferation and granulocyte-macrophage colony-stimulating factor (GM-CSF) release. Results: NM-C and NP-AERD samples and fibroblasts expressed EP2, EP3 and EP4 at baseline. Lower expression of EP2 and higher expression of EP4 was observed in NP-AERD compared with NM-C. Stimulation with PGE2 and butaprost caused a higher increase in cAMP in NM-C than in NP-AERD. On the contrary, CAY10598 produced a higher production of cAMP in NP-AERD compared with NM-C. The anti-proliferative effect of PGE2 and butaprost was lower in NP-AERD than in NM-C fibroblasts. Similarly, the capacity of PGE2 and butaprost to inhibit GM-CSF release was lower in NP-AERD than in NM-C. Conclusions: The altered expression of EP2 in AERD may contribute to reduce the capacity of PGE2 to mediate anti-proliferative and anti-inflammatory effects.

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Priyadharshini, V. S., Marcos Alejandro Jiménez-Chobillon, Jos de Graaf, Raúl Porras Gutiérrez de Velasco, Christina Gratziou, Fernando Ramírez-Jiménez, and Luis M. Teran. "Transcriptome Analysis Identifies Doublesex and Mab-3 Related Transcription Factor (DMRT3) in Nasal Polyp Epithelial Cells of Patients Suffering from Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease (AERD)." Biomolecules 11, no. 8 (July 23, 2021): 1092. http://dx.doi.org/10.3390/biom11081092.

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Background: Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterised by chronic rhinosinusitis, nasal polyps, asthma and aspirin intolerance. An imbalance of eicosanoid metabolism with anover-production of cysteinyl leukotrienes (CysLTs) has been associated with AERD. However, the precise mechanisms underlying AERD are unknown. Objective: To establish the transcriptome of the nasal polyp airway epithelial cells derived from AERD patients to discover gene expression patterns in this disease. Methods: Nasal airway epithelial cells were isolated from 12 AERD polyps and 8 AERD non-polyp nasal mucosa samples as controls from the same subjects. Utilising the Illumina HiSeq 2500 platform, RNA samples were sequenced. Potential gene candidate DMRT3 was selected from the differentially-expressed genes for validation. Results: Comparative transcriptome profiling of nasal epithelial cells was accomplished in AERD. A total of 20 genes had twofold mean regulation expression differences or greater. In addition, 8 genes were upregulated, including doublesex and mab-3 related transcription factor 3 (DMRT3), and 12 genes were downregulated. Differentially regulated genes comprised roles in inflammation, defence and immunity. Metabolic process and embryonic development pathways were significantly enriched. Enzyme-linked immune sorbent assay (ELISA) results of DMRT3 in AERD patients were significantly upregulated compared to controls (p = 0.03). Immunohistochemistry (IHC) of AERD nasal polyps localised DMRT3 and was predominantly released in the airway epithelia. Conclusion: Findings suggest that DMRT3 could be potentially involved in nasal polyp development in AERD patients. Furthermore, several genes are downregulated, hinting at the dedifferentiation phenomenon in AERD polyps. However, further studies are imperative to confirm the exact mechanism of polyp formation in AERD patients.

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Davis, B. J. "AED withdrawal." Neurology 48, no. 4 (April 1, 1997): 1137. http://dx.doi.org/10.1212/wnl.48.4.1137-a.

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Manek, P. "AED value." British Dental Journal 210, no. 11 (June 2011): 501. http://dx.doi.org/10.1038/sj.bdj.2011.432.

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Kampel, Ludwig, Manuel Leithner, and Dimitris E. Simos. "Sliced AETG: a memory-efficient variant of the AETG covering array generation algorithm." Optimization Letters 14, no. 6 (August 3, 2019): 1543–56. http://dx.doi.org/10.1007/s11590-019-01459-0.

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Alrumaihi, Faris, Khaled S. Allemailem, Ahmad Almatroudi, Mohammed A. Alsahli, Arif Khan, and Masood A. Khan. "Tinospora cordifolia Aqueous Extract Alleviates Cyclophosphamide- Induced Immune Suppression, Toxicity and Systemic Candidiasis in Immunosuppressed Mice: In vivo Study in Comparison to Antifungal Drug Fluconazole." Current Pharmaceutical Biotechnology 20, no. 12 (October 18, 2019): 1055–63. http://dx.doi.org/10.2174/1389201019666190722151126.

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Objective: The present study was aimed to evaluate the effect of the aqueous extract of Tinospora cordifolia (AETC) against cyclophosphamide-induced immunosuppression and systemic Candida albicans infection in a murine model. Methods: The protective effect of AETC against cyclophosphamide-induced leukopenia was evaluated by quantitative and qualitative analysis of the leukocytes. The immune-stimulating potential of AETC on macrophages was assessed by determining the levels of secreted cytokines. To determine the direct antifungal activity, AETC or fluconazole was administered to C. albicans infected mice. The efficacy of treatment was assessed by determining the survival rate, kidney fungal burden, the organ index and liver inflammation parameters. Results: Cyclophosphamide administration resulted in substantial depletion of leukocytes, whereas AETC treatment induced the recovery of leukocytes in cyclophosphamide-injected mice. Moreover, AETC treatment of macrophages resulted in enhanced secretion of IFN-γ, TNF-α and IL-1β. C. albicans infected mice treated with AETC at the doses of 50 and 100 mg/kg exhibited 40% and 60% survival rate, whereas the mice treated with fluconazole at a dose of 50 mg/kg showed 20% survival rate. Like survival data, the fungal load was found to be the lowest in the kidney tissues of mice treated with AETC at a dose of 100 mg/kg. Interestingly, mice infected with C. albicans demonstrated improvement in the organ indices and liver functioning after AETC treatment. Conclusion: These results suggest that AETC may potentially be used to rejuvenate the weakened immune system and eliminate systemic candidiasis in mice.

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Sowmya, Manohar VR, Mohandas Rai, H. N. Gopalakrishna, and Chandrashekar R. "Effect of aqueous Extract of Terminalia bellirica fruit pulp on Alcohol affected learning in swiss albino mice." IP International Journal of Comprehensive and Advanced Pharmacology 6, no. 2 (August 15, 2021): 76–78. http://dx.doi.org/10.18231/j.ijcaap.2021.013.

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To evaluate the effect of Aqueous extract of Terminalia belliricafruit pulp (AETB) on learning by Hebb William maze model in mice with acute alcohol consumption.Swiss albino mice (n=48) of either sex weighing 20-30g will be divided into eight groups of six mice each. Drugs were given orally after 12 hours of fasting. Group I mice received 10ml/kg of Normal Saline, Group II mice received Piracetam 200mg/kg, Group III received AETB 36mg/kg, Group IV received ethanol 1.5g/kg orally, Group V received ethanol(1.5g/kg )+ piracetam (200mg/kg), Group VI mice received ethanol(1.5g/kg) +AETB(9mg/kg), Group VII mice received ethanol(1.5g/kg) +AETB (18mg/kg), Group VIII mice received ethanol(1.5g/kg) +AETB(36mg/kg). Time taken by the animal to reach the reward chamber from the start chamber (TRC) in Hebb-William maze was used as a parameterto evaluate the learning.Acute alcohol administration showed increase in TRC. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp showed a decrease in TRC when compared to the control group. The TRC values for the groups that were administered AETB along with acute alcohol administration showed decrease in TRC values compared to the negative control.Current study showed acute alcohol administration caused impairment of thelearning ability in mice. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp (AETB)caused enhancement of learning. Pre-treatment with AETB before acute alcohol administration indicated protective action of AETB on alcohol affected learning in mice.

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Botti, Giada, Alessandro Dalpiaz, and Barbara Pavan. "Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration." Pharmaceutics 13, no. 8 (July 27, 2021): 1144. http://dx.doi.org/10.3390/pharmaceutics13081144.

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About 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs. Unfortunately, lipidization often transforms a hydrophilic neuroactive agent into an active efflux transporter (AET) substrate, with consequent rejection from the brain after permeation across the blood brain barrier (BBB). Currently, the prodrug approach has greatly evolved in comparison to lipidization. This review describes the evolution of the prodrug approach for brain targeting considering the design of prodrugs as active influx substrates or molecules able to inhibit or elude AETs. Moreover, the prodrug approach appears strategic in optimization of the encapsulation of neuroactive drugs in nanoparticulate systems that can be designed to induce their receptor-mediated transport (RMT) across the BBB by appropriate decorations on their surface. Nasal administration is described as a valuable alternative to obtain the brain targeting of drugs, evidencing that the prodrug approach can allow the optimization of micro or nanoparticulate nasal formulations of neuroactive agents in order to obtain this goal. Furthermore, nasal administration is also proposed for prodrugs characterized by peripheral instability but potentially able to induce their targeting inside cells of the brain.

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Wang, Julan. "A Comparative Study on Teacher Talk of Australian and Chinese English Teachers in an Academic English Writing Course in Chinese EFL Classrooms." Journal of Language Teaching and Research 10, no. 4 (July 1, 2019): 776. http://dx.doi.org/10.17507/jltr.1004.12.

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Research on teacher talk has shown that many different teaching behaviors between native English speaking teachers and non-native English speaking teachers may result form their different English proficiency. This paper aims to examine the differences between Australian English teachers (AETs) and Chinese English teachers (CETs) in an Academic English Writing course in ELF classrooms in China in terms of language use, linguistic complexity, and linguistic variety. Two university teachers (one AET and one CET) were recorded and observed for two weeks in October of 2017 in SHU-UTS Business School of Shanghai University. Data were collected via classroom observation and analyzed by a qualitative research method. The findings revealed although there are some differences in language use, linguistic complexity and linguistic variety, both teachers are highly aware of the marking criteria for the writing task of the academic English writing course and emphasize their teacher talk quality input for their students. The results, therefore, can help teachers from Australian and Chinese cultures to continuously work on high quality teacher talk and facilitate the development of a specific language skill-academic English writing for English learners in EFL Chinese classrooms.

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Mendes, Davidson Passos, Mariana Muniz de Oliveira, Virgínia Gonçalves de Matos, Marcela Borja Mazoni, and Geraldo Fabiano de Souza Moraes. "Do prescrito ao real: a gestão individual e coletiva dos trabalhadores de enfermagem frente ao risco de acidente de trabalho." Gestão & Produção 19, no. 4 (December 2012): 885–92. http://dx.doi.org/10.1590/s0104-530x2012000400016.

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Esse artigo tem por objetivo levantar os constrangimentos enfrentados pelos auxiliares e técnicos de enfermagem (AeTE) de uma instituição pediátrica, vinculada a uma fundação estatal, em sua atividade de trabalho e identificar estratégias utilizadas por eles que garantam as metas de produção, a satisfação do trabalhador e a sua autoproteção contra os acidentes de trabalho. Por meio do método da AET, foram utilizados para análise e coleta de dados 34 trabalhadores de enfermagem - nível médio e técnico -, entre efetivos e contratados e, observadas as estratégias de ação e regulação destes trabalhadores frente às interfaces com que lidam. Os resultados mostram que entre os constrangimentos levantados nesta Instituição, os mais evidentes são: a dupla jornada de trabalho, a diversidade de vínculos empregatícios, os riscos a que estes profissionais estão expostos e o não conhecimento do objeto de trabalho. Verifica-se que esses constrangimentos ocasionam uma elevação das cargas de trabalho física, psíquica e cognitiva. Visando reduzir essas cargas de trabalho, o trabalhador tenta criar estratégias que são adquiridas por meio da vivência com o trabalho, das experiências e valores, para se regular frente ao risco no trabalho.

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Dias, Êuder Reis, Thays de Lima Matos Freire Dias, Magna Suzana Alexandre-Moreira, and Alexsandro Branco. "Antinociceptive activity of Tibouchina pereirae, an endemic plant from the Brazilian semiarid region." Zeitschrift für Naturforschung C 71, no. 7-8 (July 1, 2016): 261–65. http://dx.doi.org/10.1515/znc-2015-0155.

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Abstract The anti-nociceptive activity of an extract of Tibouchina pereirae Aubl (AETP) was investigated using two models of chemically induced pain, viz. the acetic acid-induced writhing and the formalin test, respectively, with dipyrone and indomethacin as reference drugs, respectively. In the acetic acid-induced writhing test, AETP application (100 mg/kg) caused a significant reduction of writhing produced by acetic acid. In the formalin test, AETP reduced the formalin effects significantly only in the late phase. These findings thus indicate the involvement of AETP only in peripheral antinociceptive mechanisms. In addition, AETP exhibited good antioxidant activity (EC50 approx. 15 μg/mL) in the DPPH free radical scavenging assay.

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Bao, Zhenyu, Shanshan Yong, Xin’an Wang, Chao Yang, Jinhan Xie, and Chunjiu He. "Seismic Reflection Analysis of AETA Electromagnetic Signals." Applied Sciences 11, no. 13 (June 24, 2021): 5869. http://dx.doi.org/10.3390/app11135869.

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Acoustic and electromagnetics to artificial intelligence (AETA) is a system used to predict seismic events through monitoring of electromagnetic and geoacoustic signals. It is widely deployed in the Sichuan–Yunnan region (22° N–34° N, 98° E–107° E) of China. Generally, the electromagnetic signals of AETA stations near the epicenter have abnormal disturbances before an earthquake. When a significant decrease or increase in the signal is observed, it is difficult to quantify this change using only visual observation and confirm that it is related to an upcoming large earthquake. Considering that the AETA data comprise a typical time series, current work has analyzed the anomalism of AETA electromagnetic signals using the long short-term memory (LSTM) autoencoder method to prove that the electromagnetic anomaly of the AETA station can be regarded as an earthquake precursor. The results show that there are 2–4% anomalous points and some outliers exceeding 0.7 (after normalization) in the AETA stations within 200 km of the epicenter of the Jiuzaigou earthquake (M. 7.0) and the Yibin earthquake (M. 6.0) half a month before the earthquakes. Therefore, the AETA electromagnetic disturbance signal can be used as an earthquake precursor and for further earthquake prediction.

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Miyazato, Kyoko. "Power-sharing between NS and NNS teachers: Linguistically powerful AETs vs. culturally powerful JTEs." JALT Journal 31, no. 1 (May 1, 2009): 35. http://dx.doi.org/10.37546/jaltjj31.1-2.

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This study investigates team-teaching (TT) relationships between AETs (Assistant English Teachers) and JTEs (Japanese Teachers of English) focusing on power-sharing in Japanese high schools. From September 2003 to March 2004, a naturalistic case study was conducted with two TT pairs during bimonthly visits through class observation and individual interviews. Supplementary data were also collected by interviewing students. Research results revealed that the AETs were given full autonomy because of their language power, which caused the JTEs to become peripheral participants. This resulted in the JTEs’ dissatisfaction with their TT performance. Furthermore, the JTEs’ identity influenced by language power inequality was deeply involved in their peripheral participation, which was supported by the belief in the native speaker fallacy, the idea that NSs are automatically the best teachers of the language (Phillipson, 1992), at the educational, societal, and individual levels. 本研究は、日本の高校における日本人英語教師(JTE)と英語指導助手(AET) のティームティーチング(TT)における関係について、教師間の力配分に焦点を置き、調査することを目的とする。2003年9月から2004年３月まで、2組のTTペアを対象としたケーススタディーが実施され、月２回の訪問時に授業参観とTTペアへの個別インタビューが行われた。補足のデータとして、学生へのインタビューも併せて行われた。その結果、AETは高い英語力ゆえに、授業の自治権を完全に与えられている一方、JTEのTTへの参加は消極的となり、結果としてJTEはTTの出来栄えに対して不満を感じていたことが判明した。また、語学力の不均衡によって影響を受けたJTEのアイデンティティーが、JTEの消極的TT参加と密接に関わっており、このことは、教育界、社会、個人レベルに見られるネイティブスピーカー信仰（ネイティブスピーカーであれば自動的によい語学教師であるとする考え）が一因であることが示唆された。

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Karovich, Svetlana. "AETA—CONSERVATION AND TOURING EXHIBITIONS." AICCM Bulletin 16, no. 1-2 (January 1990): 93–102. http://dx.doi.org/10.1179/bac.1990.16.1-2.019.

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Dave, Y., G. Milne, J. Fahrenholz, and J. Oates. "15-Lte4 Levels In AERD." Journal of Allergy and Clinical Immunology 125, no. 2 (February 2010): AB50. http://dx.doi.org/10.1016/j.jaci.2009.12.231.

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Karlsson, Lena, Carolina Malta Hansen, Mads Wissenberg, Steen Møller Hansen, Freddy K. Lippert, Shahzleen Rajan, Kristian Kragholm, et al. "Data concerning AED registration in the Danish AED Network, and cardiac arrest-related characteristics of OHCAs, including AED coverage and AED accessibility." Data in Brief 24 (June 2019): 103960. http://dx.doi.org/10.1016/j.dib.2019.103960.

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White, Andrew A. "An Update on the Epidemiology of Aspirin-Exacerbated Respiratory Disease." American Journal of Rhinology & Allergy 31, no. 5 (September 2017): 299–301. http://dx.doi.org/10.2500/ajra.2017.31.4462.

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Background Aspirin-exacerbated respiratory disease (AERD) is a disorder of nasal polyposis, asthma, and hypersensitivity respiratory reactions when on systemic cyclooxygenase 1 blockade. Methods AERD Warrants Specific Evaluation As An Endotype Of Asthma And Chronic Sinus Disease Due To Unique Therapeutic Opportunities. Currently, Aspirin Therapy Is Uniquely Beneficial As An Anti-Inflammatory Therapy In Aerd, With Multiple Additional Therapies Currently In Early To Late Clinical Studies, Which Might Also Show Exceptional Benefit In AERD. Results Yet, given the lack of a simple diagnostic test, opportunities to identify patients with AERD are still frequently neglected. Conclusion Identifying the prevalence and population characteristics necessary to determine appropriate candidates in whom to perform diagnostic aspirin challenge remains critically important and was the purpose of this article.

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Zanatta, Maria Eduarda D. C., Daniela Miorando, Amanda M. Stefller, Nátali Roos, Jackeline Ernetti, Ana Júlia Predebon, Heloísa Lindemann, et al. "Gastroprotective Effects of the Aqueous Extract from Taraxacum officinale in Rats Using Ultrasound, Histology, and Biochemical Analysis." Evidence-Based Complementary and Alternative Medicine 2021 (December 21, 2021): 1–13. http://dx.doi.org/10.1155/2021/8987232.

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Taraxacum officinale F.H. Wigg. belonging to the family Asteraceae is an edible medicinal plant distributed worldwide. This study aimed to determine the gastroprotective effects of aqueous extract of T. officinale (AETo) in rats using ultrasound, histological, and biochemical analyses. In this study, gastric ulceration was induced by ethanol or piroxicam. Rats were then treated with AETo (3, 30, or 300 mg/kg). The area and histological appearance of gastric ulcers were quantified, and histochemical analysis was performed. The activity of AETo on inflammatory and oxidative stress markers was assessed in the ulcerated tissue. In addition, we investigated the thickness of the gastric wall using the ultrasound technique. Moreover, chemical analyses of AETo were performed. In rats with ethanol- or piroxicam-induced ulcers, AETo reduced the ulceration area, elevated mucin level, and the gastroprotective effect was confirmed by histological analysis. The gastroprotective effect was accompanied by increased activities of SOD, CAT, and GST, as well as an increase in GSH level and reduction in MPO activity. Furthermore, AETo reduced the thickness of the gastric wall in rats. Phytochemical analysis of AETo indicated phenolic acids and flavonoids as the main active compounds. In conclusion, the gastroprotective effect of AETo involves reduction in oxidative stress and inflammatory injury and increase in mucin content. This study advances in the elucidation of mechanisms of gastric protection of T. officinale, contributes to the prospection of new molecules gastroprotective, and proposes the ultrasonographic analyses as a new gastroprotective assessment tool in preclinical studies.

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Kasai, Ayaka, Jun Kobayashi, Makoto Nishioka, Noriko Kubota, Yuji Inaba, and Mitsuo Motobayashi. "Early Phase Increase in Serum TIMP-1 in Patients with Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion." Children 10, no. 1 (December 30, 2022): 78. http://dx.doi.org/10.3390/children10010078.

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Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most frequent subtype of acute encephalopathy syndrome among Japanese children. Exanthem subitum is the most common causative infectious disease of AESD. We herein retrospectively analyzed serum and cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor matrix metalloproteinase-1 (TIMP-1), and seven cytokines in patients with AESD or prolonged febrile seizure (FS) to assess the pathophysiology of AESD and detect biomarkers for diagnosing AESD in the early phase. Methods: Serum and CSF samples were obtained from 17 patients with AESD (1st seizure phase group, n = 7; 2nd seizure phase group, n = 10) and 8 with FS. The concentrations of MMP-9, TIMP-1, and seven cytokines were measured by enzyme-linked immunosorbent assays or cytometric bead arrays. Results: Serum concentrations of TIMP-1 were significantly higher in the 1st seizure phase group than in the 2nd seizure phase group. No significant differences were observed in serum concentrations of MMP-9 or the MMP-9/TIMP-1 ratio. Conclusions: The MMP-9-independent increase in circulating TIMP-1 concentrations observed in the present study may be associated with the pathophysiology of AESD in the 1st seizure phase.

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Schäfer, Dirk, and Steffen Maune. "Pathogenic Mechanisms and In Vitro Diagnosis of AERD." Journal of Allergy 2012 (May 10, 2012): 1–18. http://dx.doi.org/10.1155/2012/789232.

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Aspirin-exacerbated respiratory disease (AERD) refers to chronic rhinosinusitis, nasal polyposis, bronchoconstriction, and/or eosinophilic inflammation in asthmatics following the exposure to nonsteroidal anti-inflammatory drugs (NSAIDs). A key pathogenic mechanism associated with AERD is the imbalance of eicosanoid metabolism focusing on prostanoid and leukotriene pathways in airway mucosa as well as blood cells. Genetic and functional metabolic studies on vital and non-vital cells pointed to the variability and the crucial role of lipid mediators in disease susceptibility and their response to medication. Eicosanoids, exemplified by prostaglandin E2 (PGE2) and peptidoleukotrienes (pLT), are potential metabolic biomarkers contributing to the AERD phenotype. Also other mediators are implicated in the progress of AERD. Considering the various pathogenic mechanisms of AERD, a multitude of metabolic and genetic markers is suggested to be implicated and were introduced as potential biomarkers for in vitro diagnosis during the past decades. Deduced from an eicosanoid-related pathogenic mechanism, functional tests balancing PGE2 and pLT as well as other eicosanoids from preferentially vital leukocytes demonstrated their applicability for in vitro diagnosis of AERD.

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Boyapati, Anita, Ming Yan, Luke F. Peterson, Joseph R. Biggs, Michelle M. Le Beau, and Dong-Er Zhang. "A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy." Blood 109, no. 9 (December 29, 2006): 3963–71. http://dx.doi.org/10.1182/blood-2006-09-045583.

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Abstract The 8;21 chromosomal translocation occurs in 15% to 40% of patients with the FAB M2 subtype of acute myeloid leukemia (AML). This chromosomal abnormality fuses part of the AML1/RUNX1 gene to the ETO/MTG8 gene and generates the AML1-ETO protein. We previously identified a C-terminal truncated AML1-ETO protein (AEtr) in a mouse leukemia model. AEtr is almost identical to the AML1-ETO exon 9a isoform expressed in leukemia patients. Here, we describe a novel function of AEtr in the development of aneuploidy through spindle checkpoint attenuation. AEtr cells had a reduced mitotic index following nocodazole treatment, suggesting a failure in a subset of cells to arrest in mitosis with a functional spindle checkpoint. Additionally, primary leukemia cells and cell lines expressing AEtr were aneuploid. Moreover, AEtr cells had reduced levels of several spindle checkpoint proteins including BubR1 and securin following treatment with the spindle poison nocodazole. These results suggest that inactivation of the spindle checkpoint may contribute to the development of aneuploidy described in t(8;21) leukemia patients.

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Yamaguchi, Hiroshi, Tsukasa Tanaka, Azusa Maruyama, and Hiroaki Nagase. "Septic Encephalopathy Characterized by Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion and Early Nonconvulsive Status Epilepticus." Case Reports in Neurological Medicine 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/7528238.

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Infection, whether viral or bacterial, can result in various forms of brain dysfunction (encephalopathy). Septic encephalopathy (SE) is caused by an excessive immune reaction to infection, with clinical features including disturbed consciousness and seizures. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is usually accompanied by viral infection in children and is characterized by biphasic seizures and impaired consciousness. The initial neurologic symptom of AESD is typically a febrile seizure that frequently lasts longer than 30 minutes. However, the possible forms this seizure takes are unclear. For example, it is unknown if nonconvulsive status epilepticus (NCSE) could be an early seizure symptomatic of AESD. In addition, thus far no cases of combined SE and AESD have been reported. Here, we describe the first reported case of SE with AESD that notably demonstrated NCSE as an early seizure.

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Schneider, Sven, Nicholas J. Campion, Sergio Villazala-Merino, David Tianxiang Liu, Tina Bartosik, Lukas D. Landegger, Navid Ahmadi, et al. "Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease." Journal of Clinical Medicine 9, no. 4 (March 28, 2020): 925. http://dx.doi.org/10.3390/jcm9040925.

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Chronic rhinosinusitis (CRS) is a common disease that substantially impairs the quality of life (QoL). Here, we aimed to assess patients’ QoL in different subtypes of CRS and correlated this with nasal polyp size to improve the clinical understanding of the burden of disease. In this retrospective single-center study, 107 patients with the following diagnoses were analyzed: CRS without nasal polyps (CRSsNP), CRS with nasal polyps (CRSwNP), or aspirin-exacerbated respiratory disease (AERD). Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) scores and their correlation with endoscopic Total Polyp Scores (TPS) were evaluated. The mean SNOT-20 GAV scores were highest in patients with AERD (AERD = 43.4, CRSwNP = 36.3, CRSsNP = 30.9). A statistically significant correlation of total SNOT-20 GAV score with TPS was observed in CRSwNP patients (r = 0.3398, p = 0.0195), but not in AERD patients (r = 0.2341, p = 0.1407). When analyzing single SNOT-20 parameters, a strong correlation with TPS was observed for blockage/congestion of the nose, particularly in AERD patients (r = 0.65, p < 0.0001). The impact of nasal polyp size on the QoL differs amongst the subgroups of CRS. Nasal symptoms have the greatest impact on QoL in patients suffering from AERD. CRSwNP and AERD patients should be separately analyzed in clinical investigations and interpretations due to significant differences in QoL.

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Fujii, Yosuke, Masato Yashiro, Mutsuko Yamada, Tomonobu Kikkawa, Nobuyuki Nosaka, Yukie Saito, Kohei Tsukahara, Masanori Ikeda, Tsuneo Morishima, and Hirokazu Tsukahara. "Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion." Disease Markers 2018 (March 14, 2018): 1–4. http://dx.doi.org/10.1155/2018/2380179.

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Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF-α, and IFN-γ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group). Mean PCT concentrations (ng/mL) in the AESD and FS groups were significantly different, at 9.8 ± 6.7 and 0.8 ± 0.9, respectively (p=0.0006). CRP (mg/dL) were 0.79 ± 0.89 and 1.4 ± 1.0 (p=0.94), respectively; IL-6 (pg/mL) were 449.7 ± 705.0 and 118.3 ± 145.4 (p=0.20), respectively; TNF-α (pg/mL) were 18.6 ± 12.5 and 16.6 ± 6.0 (p=0.67), respectively; and IFN-γ (pg/mL) were 79.6 ± 158.5 and 41.9 ± 63.7 (p=0.56), respectively. Ratios of PCT to CRP were 27.5 ± 34.2 and 3.2 ± 6.8 (p<0.0001), respectively. The sensitivity and specificity in the diagnosis of AESD using a cutoff of PCT/CRP ratio of 1.0 were 79% and 100%, respectively. These results suggest that PCT and the PCT/CRP ratio are useful in auxiliary diagnosis of the second stage of AESD, and in AESD, PCT is likely to increase through a different mechanism.

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Mistry, N. "Register your AED." British Dental Journal 231, no. 9 (November 12, 2021): 532–33. http://dx.doi.org/10.1038/s41415-021-3626-3.

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Volk, Holger, Marios Charalabous, and David Brodbelt. "Canine AED efficacy." Companion Animal 19, no. 12 (December 2, 2014): 631. http://dx.doi.org/10.12968/coan.2014.19.12.631.

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Mardani, Zahra, Sima Dorjani, Keyvan Moeini, Majid Darroudi, Cameron Carpenter-Warren, Alexandra MZ Slawin, and J. Derek Woollins. "A novel ligand transfer reaction: Transferring an N3-donor amine ligand from Ni(II) to Cu(II)—structural, spectral, theoretical, and docking studies." Journal of Chemical Research 43, no. 9-10 (July 19, 2019): 330–39. http://dx.doi.org/10.1177/1747519819863134.

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Two complexes of N1-(2-aminoethyl)propane-1,3-diamine (AEPD), [Ni(AEPD)2](NO3)2 (1) and [Cu2( μ-Cl)2(AEPD)2](NO3)2·2H2O (2), are prepared and identified by elemental analysis, Fourier transform infrared spectroscopy and UV–Vis spectroscopy, and single-crystal X-ray diffraction (for 2). Spectral and structural data reveal that the AEPD ligand transfers from nickel to copper in the reaction between 1 and copper chloride. All coordination modes of the AEPD-based ligands are studied by analysis of the Cambridge Structural Database. The nickel atom in 1 has octahedral geometry (NiN6) while X-ray structure analysis revealed that the copper atom in the binuclear structure of 2 has an elongated square-pyramidal geometry with a CuN3OCl2 environment. In the crystal network of 2, water molecules and cationic complex units along with the nitrate ions form different hydrogen bond motifs. The thermodynamic stability of the compounds and their charge distribution patterns is studied by density functional theory and natural bond orbital analysis. The ability of AEPD and its complexes to interact with 10 selected biomacromolecules is investigated by docking calculations.

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Guo, Qinmeng, Shanshan Yong, and Xin’an Wang. "Statistical Analysis of the Relationship between AETA Electromagnetic Anomalies and Local Earthquakes." Entropy 23, no. 4 (March 30, 2021): 411. http://dx.doi.org/10.3390/e23040411.

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To verify the relationship between AETA (Acoustic and Electromagnetics to Artificial Intelligence (AI)) electromagnetic anomalies and local earthquakes, we have performed statistical studies on the electromagnetic data observed at AETA station. To ensure the accuracy of statistical results, 20 AETA stations with few data missing and abundant local earthquake events were selected as research objects. A modified PCA method was used to obtain the sequence representing the signal anomaly. Statistical results of superposed epoch analysis have indicated that 80% of AETA stations have significant relationship between electromagnetic anomalies and local earthquakes. These anomalies are more likely to appear before the earthquakes rather than after them. Further, we used Molchan’s error diagram to evaluate the electromagnetic signal anomalies at stations with significant relationships. All area skill scores are greater than 0. The above results have indicated that AETA electromagnetic anomalies contain precursory information and have the potential to improve local earthquake forecasting.

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Falfán-Valencia, Ramcés, Gandhi F. Pavón-Romero, Angel Camarena, María de la Luz García, Gustavo Galicia-Negrete, María Cristina Negrete-García, and Luis Manuel Teran. "The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population." Journal of Allergy 2012 (November 3, 2012): 1–5. http://dx.doi.org/10.1155/2012/741313.

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Abstract:

Aspirin exacerbated respiratory disease (AERD) is characterized by chronic hyperplastic rhinosinusitis, nasal polyposis, asthma, and aspirin sensitivity. The mechanisms which produce these manifestations of intolerance are not fully defined, current research focuses on cyclooxygenase 1 (COX-1) inhibition, metabolism of arachidonic acid, and the COX pathway to the lipoxygenase (LO) route, inducing increased synthesis of leukotrienes (LT). The biological plausibility of this model has led to the search for polymorphisms in genes responsible for proinflammatory cytokines synthesis, such as IL1B and IL8. We performed a genetic association study between IL8-251 (rs4073) and IL1B-511 (rs16944) polymorphisms in AERD, aspirin-tolerant asthma (ATA), and healthy control subjects. Using allelic discrimination by real-time PCR, we found statistically nonsignificant associations between AERD, ATA, and healthy control subjects for the GG and GA genotypes of IL1B (rs16944). Interestingly, the AA genotype showed an increased frequency in the AERD patients versus the ATA group (GF = 0.19 versus 0.07, , OR 2.98, and 95% CI 1.17–7.82). This is the first observation that IL1B polymorphisms are involved in AERD. Thus, future studies must investigate whether interleukin-1 is released in the airways of AERD patients and whether it relates to genetic polymorphisms in the IL1B gene.

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Journal articles on the topic 'AETD'

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