To see the other types of publications on this topic, follow the link: AEP.
Journal articles on the topic 'AEP'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'AEP.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Das, Sourav, Barbara Vörös-Horváth, Tímea Bencsik, Giuseppe Micalizzi, Luigi Mondello, Györgyi Horváth, Tamás Kőszegi, and Aleksandar Széchenyi. "Antimicrobial Activity of Different Artemisia Essential Oil Formulations." Molecules 25, no. 10 (May 21, 2020): 2390. http://dx.doi.org/10.3390/molecules25102390.
Full textAbstract:
The extreme lipophilicity of essential oils (EOs) impedes the measurement of their biological actions in an aqueous environment. We formulated oil in water type Pickering Artemisia annua EO nanoemulsions (AEP) with surface-modified Stöber silica nanoparticles (20 nm) as the stabilizing agent. The antimicrobial activity of AEP and its effects on mature Candida biofilms were compared with those of Tween 80 stabilized emulsion (AET) and ethanolic solution (AEE) of the Artemisia EO. The antimicrobial activity was evaluated by using the minimum inhibitory concentrations (MIC90) and minimum effective concentrations (MEC10) of the compounds. On planktonic bacterial and fungal cells beside growth inhibition, colony formation (CFU/mL), metabolic activity, viability, intracellular ATP/total protein (ATP/TP), along with reactive oxygen species (ROS) were also studied. Artemisia annua EO nanoemulsion (AEP) showed significantly higher antimicrobial activity than AET and AEE. Artemisia annua EO nanoemulsions (AEP) generated superoxide anion and peroxides-related oxidative stress, which might be the underlying mode of action of the Artemisia EO. Unilamellar liposomes, as a cellular model, were used to examine the delivery efficacy of the EO of our tested formulations. We could demonstrate higher effectiveness of AEP in the EO components’ donation compared to AET and AEE. Our data suggest the superiority of the AEP formulation against microbial infections.
2
Meneu, Ricard. "¿AEP para qué?" Revista de Calidad Asistencial 17, no. 8 (January 2002): 589–90. http://dx.doi.org/10.1016/s1134-282x(02)77549-0.
Full text
3
Sedval, Göran. "AEP President’s Report." European Psychiatry 17, no. 4 (July 2002): 175–78. http://dx.doi.org/10.1016/s0924-9338(02)00670-3.
Full text
4
Ahmad, Ishtiaque, Anjum Khalique, Muhammad Qamar Shahid, Abdul Ahid Rashid, Furukh Faiz, Muhammad Asim Ikram, Sheraz Ahmed, et al. "Studying the Influence of Apple Peel Polyphenol Extract Fortification on the Characteristics of Probiotic Yoghurt." Plants 9, no. 1 (January 7, 2020): 77. http://dx.doi.org/10.3390/plants9010077.
Full textAbstract:
The aim of the current study was to evaluate the effect of apple peel polyphenol extract (APPE) on the physicochemical and microbiological properties of probiotic yoghurt. Five concentrations of APPE were added in probiotic yoghurt as: (1) CTL, control without APPE; (2) AE1, addition of 1% APPE; (3) AE2, addition of 2% APPE; (4) AE3, addition of 3% APPE; (5) AE4, addition of 4% APPE; and (6) AE5, addition of 5% APPE. The prepared probiotic yoghurt was stored at 4 °C for 21 days and analyzed for physicochemical and microbiological properties. The initial viable count of L. bulgaricus, S. thermophilus, B. lactis and L. acidophilus were similar in all yoghurt samples at day 1. The maximum viability loss of probiotics was observed in CTL (p < 0.05). The lowest viability loss of probiotics was observed in AE5 samples (p < 0.05). The acidity, water holding capacity and viscosity were increased with the addition of APPE. No significant effects were observed on milk fat and total solid contents of probiotic yoghurt with the addition of APPE. The total phenolic contents of probiotic yoghurt increased significantly as 0.59, 0.71, 0.97, 1.18, 1.35 in AE1, AE2, AE3, AE4 and AE5, samples respectively. It was observed that AE3 and AE4 samples had better taste, flavour and colour with good texture. The survival of probiotics and antioxidant activity of the yoghurts were enhanced with the addition of APPE. In conclusion, apple peels could be successfully used as prebiotic in yoghurt with increased viable counts of probiotics.
5
Chertoff, Mark E., Kurt E. Hecox, and Robert Goldstein. "Auditory Distortion Products Measured With Averaged Auditory Evoked Potentials." Journal of Speech, Language, and Hearing Research 35, no. 1 (February 1992): 157–66. http://dx.doi.org/10.1044/jshr.3501.157.
Full textAbstract:
The purpose of this investigation was to describe the properties of averaged auditory evoked potential distortion products (AEP-DPs) in guinea pigs. This study provided a step toward developing a clinical index of nonlinear processing of auditory signals and supplied a baseline for studies evaluating the effect of cochlear damage on AEP-DPs. The amplitude of the AEP-DPs was evaluated as a function of f2/fl ratio (1.12–1.52) and primary frequency (500 Hz–2000 Hz). The amplitude of the AEP cubic difference tone (AEP-CDT) increased with increasing f2/fl ratio for the 500-Hz f1 primary and remained constant for the 800-Hz and 1700-Hz f1 primaries. The AEP-CDT generated by the 1100-Hz and 1400 Hz f1 primaries was maximum for the middle f2/fl ratios (1.22, 1.32, and 1.42). The AEP-CDT could not be distinguished from the noise floor for the 2000-Hz f1 primary. The AEP difference tone (AEP-DT) was larger and more frequently identified than the AEP-CDT. The amplitude of the AEP-DT decreased with an increase in f2/f1 ratio. The decrease was more pronounced for low-frequency f1 primaries than for high-frequency f1 primaries.
6
Schwarz, G., J. Brandenburg, M. Reich, T. Burster, C. Driessen, and H. Kalbacher. "Characterization of Legumain." Biological Chemistry 383, no. 11 (November 13, 2002): 1813–16. http://dx.doi.org/10.1515/bc.2002.203.
Full textAbstract:
Abstract The mammalian legumain, also called asparaginyl endopeptidase (AEP), is critically involved in the processing of bacterial antigens for MHC class II presentation. In order to investigate the substrate specificity of AEP in the P1 position, we created a peptide library and digested it with purified pig kidney AEP. Digestion was less efficient only when proline was in the P1 position. Maximum AEP activity was found in lysosomal fractions of different types of antigen presenting cells (APC). When the multiple sclerosisassociated autoantigen myelin basic protein (MBP) was digested with AEP, the immunodominant epitope 8399 was destroyed. Myoglobin as an alternative substrate was AEP resistant. These results suggest an important, but not necessarily critical role for AEP in lysosomal antigen degradation.
7
Zhang, Wenrui, and Yingying Lin. "The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review." Cells 10, no. 5 (May 10, 2021): 1153. http://dx.doi.org/10.3390/cells10051153.
Full textAbstract:
Asparagine endopeptidase (AEP), also called legumain, is currently the only known cysteine protease that specifically cleaves peptide bonds in asparaginyl residue in the mammalian genome. Since 2003, AEP has been reported to be widely expressed in a variety of carcinomas and is considered a potential therapeutic target. In the following years, researchers intensively investigated the substrates of AEP and the mechanism of AEP in partial tumors. With the identification of substrate proteins such as P53, integrin αvβ3, MMP-2, and MMP-9, the biochemical mechanism of AEP in carcinomas is also more precise. This review will clarify the probable mechanisms of AEP in the progression of breast carcinoma, glioblastoma, gastric carcinoma, and epithelial ovarian carcinoma. This review will also discuss the feasibility of targeted therapy with AEP inhibitor (AEPI) in these carcinomas.
8
Pull, C. B., and J. M. Cloos. "Internet strategies for AEP." European Psychiatry 17 (May 2002): 70. http://dx.doi.org/10.1016/s0924-9338(02)80320-0.
Full text
9
Silva, André Luís Silva da, Marcello Ferreira, Samara Magalhães Pereira, and Olavo Leopoldino da Silva Filho. "Atividade experimental problematizada (AEP)." Revista Pesquisa e Debate em Educação 9, no. 1 (June 30, 2019): 459–71. http://dx.doi.org/10.34019/2237-9444.2019.v9.31125.
Full textAbstract:
O ensino experimental fundamentado na busca por solução de problemas baseia-se, sobretudo, na relação estabelecida entre os desafios e a busca de estratégias particularizadas para cercá-los a determinada maneira. Temos trabalhado nesta área de pesquisa nos últimos anos, investigando abordagens experimentais problematizadas (AEP). Muito se tem produzido neste campo científico, sob diversos vieses, e este trabalho se dedica a analisar determinado extrato da produção acadêmica correlata. Foram analisados 12 periódicos científicos nas áreas de Ensino, Educação, Ensino de Química e Ensino de Física, relativamente ao período de 2010 a 2015, selecionando-se 104 trabalhos de interesse. A revisão dos periódicos resultante deste trabalho fornece uma visão ampla e concreta de como a experimentação e a resolução de problemas vêm sendo estudadas/pesquisadas aproximadamente nos últimos cinco anos, em particular na correlação que se estabelece entre elas.
10
Marsico, R., R. D. Ryan, and R. L. Retallack. "AEP Chainette Structure Development." IEEE Power Engineering Review PER-5, no. 10 (October 1985): 44. http://dx.doi.org/10.1109/mper.1985.5528699.
Full text
11
Marsico, R., R. Ryan, and R. Retallack. "Aep Chainette Structure Development." IEEE Transactions on Power Apparatus and Systems PAS-104, no. 10 (October 1985): 2844–51. http://dx.doi.org/10.1109/tpas.1985.319128.
Full text
12
Schneider, Gerhard, Eberhard F. Kochs, Henry Arenbeck, Michael Gallinat, and Gudrun Stockmanns. "Signal Verification of Middle Latency Auditory Evoked Potentials by Automated Detection of the Brainstem Response." Anesthesiology 101, no. 2 (August 1, 2004): 321–26. http://dx.doi.org/10.1097/00000542-200408000-00012.
Full textAbstract:
Background The midlatency components of auditory evoked potentials (AEPs) are gradually suppressed with increasing concentrations of anesthetics. Thus, they have been proposed as a monitor of anesthetic depth. However, undetected malfunction or disconnection of headphones and undetected hearing loss also result in suppressed midlatency AEPs that in turn may be misinterpreted as signs of deep anesthesia. As the brainstem component of the AEP is minimally influenced by anesthetics, its presence or absence can be used to verify that the recorded signal is a true AEP rather than an artifact. In this study, an online-capable procedure for detection of the brainstem component of the AEP was developed. Methods One hundred and ninety perioperatively recorded AEPs (binaural stimuli, 500 sweeps) were selected from a database with electroencephalographic and concomitant AEP stimulus information. Identical electroencephalogram regions were used to produce nonstimulus synchronized averaged signals (500 sweeps, "non-AEP"). The 190 AEPs and 190 "non-AEPs" were used to develop a detector of the brainstem component of AEPs. AEPs and "non-AEPs" were wavelet transformed (discrete wavelet decomposition, biorthogonal 2.2 mother-wavelet), and the coefficient with the best separation of the two classes of signals was selected. Receiver operating characteristic curve analysis was performed to determine the optimum threshold value for this coefficient. Results The third coefficient of the third level was selected. In AEP signals, retransform of this coefficient produces a peak that resembles peak V of the brainstem response. The developed detector of the brainstem component of AEP had a sensitivity of 97.90% and a specificity of 99.48%. Conclusions This detector of the AEP brainstem component can be used to verify that the signal reflects the response to an auditory stimulus. An alternative approach, used in the Danmeter AEP monitor, is based on the signal-to-noise ratio of the midlatency components of the AEP. Because the midlatency components of AEP are suppressed by anesthesia, a false alarm "low AEP/no AEP" is generated during deep anesthesia. This, in turn, may suggest disconnection of headphones or technical problems whenever anesthesia is deep. This disadvantage has been overcome by our detector, which is based on the identification of the brainstem component of AEP.
13
Burina, Adnan, Osman Sinanović, Dževdet Smajlović, Mirjana Vidović, and Fuad Brkić. "Some Aspects of Balance Disorder in Patients with Multiple Sclerosis." Bosnian Journal of Basic Medical Sciences 8, no. 1 (February 20, 2008): 80–85. http://dx.doi.org/10.17305/bjbms.2008.3003.
Full textAbstract:
The aim of this study was to analyze: frequency of balance disorder (vertigo and disequilibrium), frequency of abnormalities in auditory evoked potentials (AEP) and magnetic resonance imaging (MRI) changes of the brain in multiple sclerosis (MS) patients with balance disorder, relation of patients disability status to balance disorder and relation of the changes in MRI of the brainstem to AEP abnormalities. It was analyzed 60 patients with relapsing-remitting form of MS. Two groups of patients were made consecutively under Expanded Disability Status Scale score (EDSS): A (EDSS <4,5) and B (EDSS >5,0). The study was retrospective-prospective. After the neurological exam AEP and MRI of the brain have been done. Balance disorder has been verified as initial symptom in 29 (48,4%) and out of them disequilibrium experienced 24 (83,4%) patients. During the relapses balance disorder experienced 48 (80%) patients and in 37 (77,1%) it was disequilibrium. Among them 33 (68,7%) were with lower EDSS (<4,5) and 15 (31,3%) with higher EDSS score (>5). There is no correlation between disability status and vertigo which means that vertigo is not more frequent in more disabled patients and vice-versa. The AEP were pathological in 57 (95%) patients. Of all 29 patients with vertigo AEP were pathological in 28 (96,5%) while in 31 patients without vertigo pathological AEP were in 29 (93,5%) but it is not statistical significant. The most frequent characteristic of AEP changes were prolonged inter-peak latency III-V waves (48 patients or 80%). The plaque in brainstem visualized by MRI was found in 41 (71,8%) of patients (38 or 92,6% of them had pathological AEP and in three patients AEP were normal). In group of patients with pathological AEP, 38 (66,6%) of them had plaque in brainstem. In other three patients with normal AEP it was visualized plaque in brainstem. In the group of 29 patients with balance disorder, 20 (68,9%) had plaque in brainstem as well as 21 (67,7%) out of 31 patients without balance disorder had plaque in the brainstem. This difference is not statistical significant. It is concluded that the vertigo (including disequilibrium) is relatively often (48,4%) initial symptom of MS. Vertigo is not more frequent in patients with higher EDSS score and vice-versa. Pathological AEP are frequent neurophysiologic finding in both (95%) patients with (96,5%) and without (93,5%) vertigo. The most often pathological characteristic of AEP are prolonged interpeak latency of III-V waves (78,5%), as well as abnormalities of V and than IV wave. MS plaques in brainstem visualized by MRI technique are frequent in both groups of patients with and without pathological finding of the AEP.
14
Patel, Naina, Shekhar Krishnan, Marc N. Offman, Cathy X. Moss, Hany Ariffin, Fred W. vanDelft, Olga Yiannikouris, et al. "Lymphoblasts Produce a Lysosomal Protease That Rapidly Degrades L-Asparaginase - Implications for Therapy in Childhood Acute Lymphoblastic Leukemia." Blood 110, no. 11 (November 16, 2007): 2791. http://dx.doi.org/10.1182/blood.v110.11.2791.2791.
Full textAbstract:
Abstract The efficacy of the key anti-leukaemic agent E.coli L-Asparaginase (L-Asp) is limited by variable therapeutic activity and development of antibodies/hypersensitivity. Observing more frequent clinical hypersensitivity in children with high risk acute lymphoblastic leukaemia (ALL), we speculated that L-Asp was proteolytically degraded by lymphoblasts, generating immunogenic fragments. On incubation with whole cell lysate from a lymphoblastic cell line, L-Asp was cleaved into at least three fragments. This cleavage was blocked only by MV026630, a specific inhibitor of the cysteine protease Asparaginyl Endopeptidase (AEP). Incubation of L-Asp with purified recombinant AEP produced an identical cleavage pattern at the carboxy termini of specific asparagine and aspartate residues. The level of AEP expression at diagnosis in 148 childhood ALL patients was measured using U133A, Exon 1.0 ST arrays and quantitative PCR. High levels of expression were detected in 38 patients (25%), including all 6 patients with clinical hypersensitivity. Elevated AEP expression was more commonly observed in high-risk disease (42% v 21%). Molecular modelling of AEP cleavage sites predicts that the N-terminal cleavage site (C1) provides tetramer stability while the highly-conserved second cleavage site (C2) is critical for tetramer formation and enzyme activity. This model was confirmed by analyses of recombinant L-Asp variants mutated to resist AEP cleavage. Cleavage is sequential from the N terminus. A product resistant to cleavage at C1 is not degraded by AEP, forms a tetramer and retains enzymatic activity comparable to the wild-type. The C2 mutated product shows little activity and is rapidly degraded by AEP. Known antigenic epitopes of L-Asp are retained within AEP-cleaved fragments. The contribution of AEP to antigenic processing of L-Asp is being investigated by T-cell activation assays using a synthetic peptide library and T cells from patients with known hypersensitivity. Thus patients with AEP-overexpressing lymphoblasts may not benefit from L-Asp therapy either due to inactivation, the development of antibodies or both. Replacement of a single amino acid of L-Asp can prevent this process without loss of activity. This product potentially has a longer half-life and less antigenicity. Our investigations have identified a hitherto unknown pathway for L-Asp degradation and a novel mechanism of drug resistance in childhood ALL. These observations require further validation by correlation of AEP expression with asparaginase activity and antibody formation in children receiving L-Asp during treatment for ALL. Further potential improvements in therapy could include screening for AEP expression at diagnosis and the use of non E Coli asparaginase or preferably a modified recombinant L-Asp and/or AEP inhibitors for those with high levels of expression.
15
Zhang, Fan, Ying Wu, Xiaohan Zou, Qinglian Tang, Fang Zhao, and Zhengyu Cao. "BmK AEP, an Anti-Epileptic Peptide Distinctly Affects the Gating of Brain Subtypes of Voltage-Gated Sodium Channels." International Journal of Molecular Sciences 20, no. 3 (February 8, 2019): 729. http://dx.doi.org/10.3390/ijms20030729.
Full textAbstract:
BmK AEP, a scorpion peptide purified form the venom of Buthus martensii Karsch, has been reported to display anti-epileptic activity. Voltage-gated sodium channels (VGSCs) are responsible for the rising phase of action potentials (APs) in neurons and, therefore, controlling neuronal excitability. To elucidate the potential molecular mechanisms responsible for its anti-epileptic activity, we examined the influence of BmK AEP on AP firing in cortical neurons and how BmK AEP influences brain subtypes of VGSCs (Nav1.1–1.3 and Nav1.6). BmK AEP concentration-dependently suppresses neuronal excitability (AP firing) in primary cultured cortical neurons. Consistent with its inhibitory effect on AP generation, BmK AEP inhibits Na+ peak current in cortical neurons with an IC50 value of 2.12 µM by shifting the half-maximal voltage of activation of VGSC to hyperpolarized direction by ~7.83 mV without affecting the steady-state inactivation. Similar to its action on Na+ currents in cortical neurons, BmK AEP concentration-dependently suppresses the Na+ currents of Nav1.1, Nav1.3, and Nav1.6, which were heterologously expressed in HEK-293 cells, with IC50 values of 3.20, 1.46, and 0.39 µM with maximum inhibition of 82%, 56%, and 93%, respectively. BmK AEP shifts the voltage-dependent activation in the hyperpolarized direction by ~15.60 mV, ~9.97 mV, and ~6.73 mV in Nav1.1, Nav1.3, and Nav1.6, respectively, with minimal effect on steady-state inactivation. In contrast, BmK AEP minimally suppresses Nav1.2 currents (~15%) but delays the inactivation of the channel with an IC50 value of 1.69 µM. Considered together, these data demonstrate that BmK AEP is a relatively selective Nav1.6 gating modifier which distinctly affects the gating of brain subtypes of VGSCs.
16
Yaver, D. S., S. Matoba, and D. M. Ogrydziak. "A mutation in the signal recognition particle 7S RNA of the yeast Yarrowia lipolytica preferentially affects synthesis of the alkaline extracellular protease: in vivo evidence for translational arrest." Journal of Cell Biology 116, no. 3 (February 1, 1992): 605–16. http://dx.doi.org/10.1083/jcb.116.3.605.
Full textAbstract:
Replacement of the signal recognition particle (SRP) 7S gene (SCR1) on a replicating plasmid with scr1-1 (G to A at 129 and A to T at 131 in the consensus sequence -GNAR- in the loop of domain III) resulted in temperature sensitivity for growth of cells in which both chromosomal SRP 7S RNA genes were deleted. Pulse-chase immunoprecipitation experiments were done after a shift to non-permissive temperature using the major secreted protein the alkaline extracellular protease (AEP) as a reporter molecule. No untranslocated AEP precursor was detected in a strain with scr1-1 on a plasmid, but the amount of the largest AEP precursor (55 kD) immunoprecipitated as a percentage of total protein synthesized was reduced 68% compared to an isogenic strain with SCR1 on the plasmid. The possibility that an untranslocated precursor was synthesized but not detected because of instability was largely eliminated by detection of a 53-kD untranslocated precursor of a mutated AEP (P17M; methionine replaced proline in the second position of the pro-peptide) which chased to the 55-kD translocated AEP precursor. Thus, SRP has a role in the biosynthesis of AEP. Possibly, the scr1-1 mutation does not affect signal recognition or translational arrest but instead results in maintenance of translational arrest of AEP synthesis. The results also suggest that AEP can be translocated in vivo either co-translationally in which SRP is at least involved in biosynthesis or posttranslationally without SRP involvement.
17
Rachid, Mohamad, Khansa Ahmad, Meghan Saunders-Kurban, Aelia Fatima, Aditya Shah, and Anas Nahhas. "Daptomycin-Induced Acute Eosinophilic Pneumonia: Late Onset and Quick Recovery." Case Reports in Pulmonology 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/8525789.
Full textAbstract:
Background. Daptomycin is a cyclic lipopeptide antibiotic that provides great coverage for gram positive cocci. From the early years of daptomycin use, concerns were raised regarding the pulmonary side effects of daptomycin and potential development of acute eosinophilic pneumonia (AEP) secondary to daptomycin therapy. Discussion. AEP could be idiopathic or induced by drugs or toxins. It is a distinct entity from atopic diseases and autoimmune, parasitic, or fungal infections that can also cause pulmonary eosinophilia. Multiple medications are associated with acute eosinophilic pneumonia. Multiple cases of daptomycin-induced AEP have been reported in the literature. Diagnosis of AEP is based on clinical history, laboratory tests, and radiographic studies. Obtaining bronchoalveolar lavage or lung biopsy is needed to confirm the diagnosis. Timing of the drug use and clinical presentation is crucial in the diagnosis of drug-induced AEP. Discontinuation of the offending drug and systemic corticosteroids are the mainstay treatment with great outcomes and recovery. Conclusion. We present a case of AEP caused by daptomycin, with complete recovery after discontinuation of daptomycin and administration of steroids. The patient had AEP after almost 6 weeks of daptomycin therapy which has never been reported in literature and our patient achieved complete recovery with appropriate management.
18
Lin, Yingying, Keman Liao, Yifeng Miao, Zhongrun Qian, Zhaoyuan Fang, Xi Yang, Quanmin Nie, et al. "Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma." JNCI: Journal of the National Cancer Institute 112, no. 4 (July 27, 2019): 343–55. http://dx.doi.org/10.1093/jnci/djz155.
Full textAbstract:
Abstract Background Isocitrate dehydrogenase wild-type (WT) glioblastoma (GBM) accounts for 90% of all GBMs, yet only 27% of isocitrate dehydrogenase WT-GBMs have p53 mutations. However, the tumor surveillance function of WT-p53 in GBM is subverted by mechanisms that are not fully understood. Methods We investigated the proteolytic inactivation of WT-p53 by asparaginyl endopeptidase (AEP) and its effects on GBM progression in cancer cells, murine models, and patients’ specimens using biochemical and functional assays. The sera of healthy donors (n = 48) and GBM patients (n = 20) were examined by enzyme-linked immunosorbent assay. Furthermore, effects of AEP inhibitors on GBM progression were evaluated in murine models (n = 6–8 per group). The statistical significance between groups was determined using two-tailed Student t tests. Results We demonstrate that AEP binds to and directly cleaves WT-p53, resulting in the inhibition of WT-p53-mediated tumor suppressor function in both tumor cells and stromal cells via extracellular vesicle communication. High expression of uncleavable p53-N311A-mutant rescue AEP-induced tumorigenesis, proliferation, and anti-apoptotic abilities. Knock down or pharmacological inhibition of AEP reduced tumorigenesis and prolonged survival in murine models. However, overexpression of AEP promoted tumorigenesis and shortened the survival time. Moreover, high AEP levels in GBM tissues were associated with a poor prognosis of GBM patients (n = 83; hazard ratio = 3.94, 95% confidence interval = 1.87 to 8.28; P < .001). A correlation was found between high plasma AEP levels and a larger tumor size in GBM patients (r = 0.6, P = .03), which decreased dramatically after surgery. Conclusions Our results indicate that AEP promotes GBM progression via inactivation of WT-p53 and may serve as a prognostic and therapeutic target for GBM.
19
Calliess, Iris, Kai Treichel, and Alexis Bowers. "Association of European Psychiatrists (AEP)." International Psychiatry 5, no. 3 (July 2008): 77. http://dx.doi.org/10.1192/s1749367600002186.
Full textAbstract:
Sir: Your readers may be interested to know that the Association of European Psychiatrists (AEP) held its 16th Annual Congress in Nice, France, 5-9 April 2008. There were almost 3000 delegates from 57 countries. The theme was ‘Pathways to Integrative Care.’
20
Tomac, N., N. Kuyucu, T. Tezic, F. Duru, S. Karademir, and Y. Gurer. "An epidemic form of AEP." Allergy 57, no. 12 (December 2002): 1213–14. http://dx.doi.org/10.1034/j.1398-9995.2002.23893_5.x.
Full text
21
Maj, Mario. "Letter from the AEP President." European Psychiatry 19, no. 6 (September 2004): 325. http://dx.doi.org/10.1016/j.eurpsy.2004.07.005.
Full text
22
Yokoyama, Akihiko, and Hiroshi Okuda. "The Molecular Mechanism of Transcriptional Activation By MLL-AEP Fusion Proteins." Blood 126, no. 23 (December 3, 2015): 2435. http://dx.doi.org/10.1182/blood.v126.23.2435.2435.
Full textAbstract:
Abstract Chromosomal translocations generate a variety of mixed lineage leukemia (MLL) fusion genes, which cause aggressive leukemia. Although >70 different fusion partners have been identified, the majority of the cases are caused by the chimeric genes of MLL and a component of the AEP co-activator complex (hereafter referred to as AEP), which comprises of AF4 family proteins (e.g. AF4, AF5Q31), ENL family proteins (e.g. ENL, AF9), and the P-TEFb elongation factor. MLL-AEP fusion proteins constitutively activate their target genes by recruiting AEP components to their target chromatin, whereas wild-type MLL recruits AEP in a context-dependent manner. In the hematopoietic lineage, MLL fusion proteins aberrantly activate a subset of genes implicated in the hematopoietic stem cell (HSC) program, such as HOXA9 and MEIS1. Constitutive expression of these HSC program genes in hematopoietic progenitors has been shown to induce leukemia in a mouse model. It has been speculated that MLL-AEP activates transcription of those HSC program genes by aberrantly activating transcription elongation. However, it is largely unclear how AEP activates transcription. Using an extensive structure/function analysis, we revealed that a serine-rich domain of the AF4 family proteins, termed pSER, is an essential functional component of MLL-AEP-dependent gene activation and leukemic transformation. Through biochemical purification, we have identified Selectivity Factor 1 (SL1) as a novel factor associated with the pSER domain. SL1 comprises TBP and four TBP-associated factors (TAF1A, TAF1B, TAF1C, TAF1D), and is known as a core component of the pre-initiation complex (PIC) of RNA polymerase I (RNAP1). In the presence of UBF, SL1 forms a PIC on the promoters of ribosomal RNA genes, to drive RNAP1-dependent transcription. However, its role in RNAP2-dependent transcription was unknown. The initiation of RNAP2-dependent transcription in eukaryotes occurs through the loading of TBP to the promoter, via a direct association with the TATA element or through as-yet-unidentified mechanisms. Our results demonstrate that AEP facilitates the initiation of RNAP2-dependent transcription via the loading of TBP onto the TATA element, through SL1 activity. MLL-AEP fusion proteins utilize this TBP-loading function to activate transcription initiation in leukemic transformation. The wild-type AEP complex activates gene expression in the same manner in the physiological conditions. Taken together, our results unveil a novel role of SL1 as a TBP-loading factor in RNAP2-dependent gene activation, and a previously unknown transcription initiation mechanism involving AEP, which is more important than its transcription elongation activities for leukemic transformation. These findings greatly advance our understanding of the molecular mechanism of MLL fusion-dependent leukemic transformation, which was previously interpreted simply as mis-regulated transcription elongation. Disclosures Yokoyama: Dainipon Sumitomo Pharma Co., Ltd.: Research Funding.
23
Matoba, S., J. Fukayama, R. A. Wing, and D. M. Ogrydziak. "Intracellular precursors and secretion of alkaline extracellular protease of Yarrowia lipolytica." Molecular and Cellular Biology 8, no. 11 (November 1988): 4904–16. http://dx.doi.org/10.1128/mcb.8.11.4904.
Full textAbstract:
Processing and secretion of the alkaline extracellular protease (AEP) from the yeast Yarrowia lipolytica was studied by pulse-chase and immunoprecipitation experiments. Over half of newly synthesized AEP was secreted by 6 min. Over 99% of AEP activity which was external to the cytoplasmic membrane was located in the supernatant medium. Polypeptides of 55, 52, 44, 36, and 32 kilodaltons (55K, 52K, 44K, 36K, and 32K polypeptides) were immunoprecipitated from [3H]leucine-labeled cell extracts by rabbit antibodies raised against mature, secreted AEP (32K polypeptide). Experiments with tunicamycin and endoglycosidase H indicated that the 55K, 52K, and 44K polypeptides contained about 2 kilodaltons of N-linked oligosaccharide and that the 36K and 32K polypeptides contained none. Results of pulse-chase experiments did not fit a simple precursor-product relationship of 55K----52K----44K----36K----32K. In fact, maximum labeling intensity of the 52K polypeptide occurred later than for the 44K and 36K polypeptides. Secretion of polypeptides of 19 and 20 kilodaltons derived from the proregion of AEP indicated that one major processing pathway was 55K----52K----32K. The gene coding for AEP (XPR2) was cloned and sequenced. The sequence and the immunoprecipitation results suggest that AEP is originally synthesized with an additional preproI-proII-proIII amino-terminal region. Processing definitely involves cleavage(s) after pairs of basic amino acids and the addition of one N-linked oligosaccharide. Signal peptidase cleavage, dipeptidyl aminopeptidase cleavages, and at least one additional proteolytic cleavage may also be involved.
24
Matoba, S., J. Fukayama, R. A. Wing, and D. M. Ogrydziak. "Intracellular precursors and secretion of alkaline extracellular protease of Yarrowia lipolytica." Molecular and Cellular Biology 8, no. 11 (November 1988): 4904–16. http://dx.doi.org/10.1128/mcb.8.11.4904-4916.1988.
Full textAbstract:
Processing and secretion of the alkaline extracellular protease (AEP) from the yeast Yarrowia lipolytica was studied by pulse-chase and immunoprecipitation experiments. Over half of newly synthesized AEP was secreted by 6 min. Over 99% of AEP activity which was external to the cytoplasmic membrane was located in the supernatant medium. Polypeptides of 55, 52, 44, 36, and 32 kilodaltons (55K, 52K, 44K, 36K, and 32K polypeptides) were immunoprecipitated from [3H]leucine-labeled cell extracts by rabbit antibodies raised against mature, secreted AEP (32K polypeptide). Experiments with tunicamycin and endoglycosidase H indicated that the 55K, 52K, and 44K polypeptides contained about 2 kilodaltons of N-linked oligosaccharide and that the 36K and 32K polypeptides contained none. Results of pulse-chase experiments did not fit a simple precursor-product relationship of 55K----52K----44K----36K----32K. In fact, maximum labeling intensity of the 52K polypeptide occurred later than for the 44K and 36K polypeptides. Secretion of polypeptides of 19 and 20 kilodaltons derived from the proregion of AEP indicated that one major processing pathway was 55K----52K----32K. The gene coding for AEP (XPR2) was cloned and sequenced. The sequence and the immunoprecipitation results suggest that AEP is originally synthesized with an additional preproI-proII-proIII amino-terminal region. Processing definitely involves cleavage(s) after pairs of basic amino acids and the addition of one N-linked oligosaccharide. Signal peptidase cleavage, dipeptidyl aminopeptidase cleavages, and at least one additional proteolytic cleavage may also be involved.
25
Gao, Han, Wencheng Zhang, Bingsong Wang, Ailing Hui, Biao Du, Tingting Wang, Ling Meng, Huixi Bian, and Zeyu Wu. "Purification, characterization and anti-fatigue activity of polysaccharide fractions from okra (Abelmoschus esculentus (L.) Moench)." Food & Function 9, no. 2 (2018): 1088–101. http://dx.doi.org/10.1039/c7fo01821e.
Full text
26
Chen, Chun, Eun Hee Ahn, Seong Su Kang, Xia Liu, Ashfaqul Alam, and Keqiang Ye. "Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model." Science Advances 6, no. 31 (July 2020): eaba0466. http://dx.doi.org/10.1126/sciadv.aba0466.
Full textAbstract:
The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer’s disease (AD). CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP) signaling spatiotemporally mediates AD pathologies in the brain via cleaving both β-amyloid precursor protein and Tau. We show that gut dysbiosis occurs in 5xFAD mice, and is associated with escalation of the C/EBPβ/AEP pathway in the gut with age. Unlike that of aged wild-type mice, the microbiota of aged 3xTg mice accelerate AD pathology in young 3xTg mice, accompanied by active C/EBPβ/AEP signaling in the brain. Antibiotic treatment diminishes this signaling and attenuates amyloidogenic processes in 5xFAD, improving cognitive functions. The prebiotic R13 inhibits this pathway and suppresses amyloid aggregates in the gut. R13-induced Lactobacillus salivarius antagonizes the C/EBPβ/AEP axis, mitigating gut leakage and oxidative stress. Our findings support the hypothesis that C/EBPβ/AEP signaling is activated by gut dysbiosis, implicated in AD pathologies in the gut.
27
Mohd Noor, Noorfaizalfarid, Nadhirah Mohd Napi, and Izzati Farzana Ibni Amin. "The Development of Autonomous Examination Paper Application: A Case Study in UiTM Cawangan Perlis." Journal of Computing Research and Innovation 4, no. 2 (November 14, 2019): 21–30. http://dx.doi.org/10.24191/jcrinn.v4i2.105.
Full textAbstract:
Examination is a vital role to measure the capabilities of students in their learning. Hence, generating question paper in an effective way is a decisive job for educators in educational institution. Using traditional method, it is monotonous and time consuming. Today, Autonomous Examination Paper (AEP) is used to produce exam paper. Many researchers have proposed effective AEPs to be used by educators. This paper aims to investigate about AEP development and to construct AEP in UiTM Cawangan Perlis. As a result, Ad-Hoc Question Paper Application (AQPA) has been developed using Fisher-Yates algorithm to generate questions for exam paper in the university. Evaluation based on Perceived Ease of Use (PEOU) and Perceived Usefulness (PU) reveal that lecturers in the university manage to interact with AQPA and willing to use it as a tool to minimize their workload. However, more improvement must be done on AQPA to be an effective AEP. To conclude, AEP brings significance to educators and can be improved with the latest technology.
28
Taira, Even Akemi, Carolina Ruis Ferrari, Gabriel Carvalho, Talita Mendes Oliveira Ventura, Tatiana Martini, Aline Salgado Dionizio, Tamara Teodoro Araújo, Edson Crusca, Reinaldo Marchetto, and Marília Afonso Rabelo Buzalaf. "Rinsing with Statherin-Derived Peptide Alters the Proteome of the Acquired Enamel Pellicle." Caries Research 55, no. 4 (2021): 333–40. http://dx.doi.org/10.1159/000517959.
Full textAbstract:
Changes in the proteomic profile of the acquired enamel pellicle (AEP) formed for 3 min or 2 h after rinsing with a peptide containing the 15 N-terminal residues of statherin, with serines 2 and 3 phosphorylated (StatpSpS), were evaluated. Nine volunteers participated in 2 consecutive days. Each day, after professional tooth cleaning, they rinsed for 1 min with 10 mL of phosphate buffer containing 1.88 × 10<sup>−5</sup> M StatpSpS or phosphate buffer only (control). The acquired pellicle formed on enamel after 3 min or 2 h was collected with electrode filter papers soaked in 3% citric acid. After protein extraction, samples were analyzed by quantitative shotgun label-free proteomics. In the 3-min AEP, 19 and 131 proteins were uniquely identified in the StatpSpS and control groups, respectively. Proteins typically found in the AEP were only found in the latter. Only 2 proteins (neutrophil defensins) were increased upon treatment with StatpSpS, while 65 proteins (among which are several typical AEP proteins) were decreased. In the 2-h AEP, 50 and 108 proteins were uniquely found in StatpSpS and control groups, respectively. Hemoglobin subunits and isoforms of keratin were only found in the StatpSpS group, while cystatin-C, cathepsin D, and cathepsin G, isoforms of heat shock 70 and protocadherin were exclusively found in the control group. In addition, 23 proteins were increased upon treatment with StatpSpS, among which are histatin-1, serum albumin, and isoforms of neutrophil defensin and keratin, while 77 were decreased, most of them were typical AEP proteins. In both evaluated periods, rinsing with StatpSpS profoundly changed the proteomic profile of the AEP, which might impact the protective role of this integument against carious or erosive demineralization. This study provides important insights on the dynamics of the protein composition of the AEP along time, after rinsing with a solution containing StatpSpS.
29
Jamieson, Nigel B., Donald C. McMillan, Duncan J. F. Brown, and A. Michael Wallace. "Comparison of simple acid-ethanol precipitation with gel exclusion chromatography for measuring leptin binding in serum of normal subjects and cancer patients." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 2 (March 1, 2003): 185–87. http://dx.doi.org/10.1258/000456303763046157.
Full textAbstract:
Background: In humans, leptin circulates in a free form and is also bound to macromolecules. The aim of the present study was to compare a rapid acid-ethanol precipitation (AEP) method of measuring bound leptin with the more laborious gel exclusion chromatography (GEC) reference procedure. Serum samples collected from healthy subjects and cancer patients were used in this comparison. Methods: AEP and GEC methods for measuring leptin binding in serum (from 14 healthy volunteers and 14 patients with advanced non-small cell lung cancer) were adapted from previously published procedures. Results: Intra- and inter-assay precision of the AEP method were 6% ( n = 10) and 8% ( n = 10), respectively. Bland-Altman analysis of results obtained from the AEP and GEC methods indicated no significant difference in healthy controls. However, significantly higher results were obtained by the AEP method in the cancer patients. Conclusions: Evaluation of the AEP method revealed that on examination of normal subjects the method was less precise than had previously been reported. Moreover, the method gave differing results in the cancer patients when compared with the GEC method. This study indicates that careful evaluation of any new method for measuring leptin binding requires comparison with a GEC method using the sample matrix of interest.
30
Recart, Alejandro, Paul F. White, Agnes Wang, Irina Gasanova, Stephanie Byerly, and Stephanie B. Jones. "Effect of Auditory Evoked Potential Index Monitoring on Anesthetic Drug Requirements and Recovery Profile after Laparoscopic Surgery." Anesthesiology 99, no. 4 (October 1, 2003): 813–18. http://dx.doi.org/10.1097/00000542-200310000-00011.
Full textAbstract:
Background The auditory evoked potential (AEP) monitor provides an electroencephalogram-derived index (AAI) that has been reported to correlate with the central nervous system depressant effects of anesthetic drugs. This clinical utility study was designed to test the hypothesis that AAI-guided administration of the maintenance anesthetics and analgesics would improve their titration and thereby provide a faster recovery from general anesthesia. Methods Seventy consenting patients undergoing elective general surgery procedures were randomly assigned to either a control (standard clinical practice) or AEP-monitored group. Although the AEP monitor was connected to all patients, the information from the monitor was only made available to the anesthesiologists assigned to patients in the AEP-monitored group. In the AEP-monitored group, the inspired desflurane concentration was titrated to maintain an AAI value of 15-20. In the control group, the inspired desflurane concentration was varied based on standard clinical signs. The AAI values and hemodynamic variables, as well as end-tidal desflurane concentrations, were recorded at 3- to 5-min intervals. The recovery times to achieve a White fast-track score greater than 12 and an Aldrete score of 10, as well as the actual duration of the PACU stay, were evaluated at 5- to 10-min intervals. Patient satisfaction with recovery from anesthesia was assessed using a 100-point verbal rating scale at 24 h after surgery. Results The average intraoperative AAI value in the AEP-monitored group was significantly higher than in the control group (16 +/- 5 vs. 11 +/- 8, P < 0.05). Use of the AEP monitor reduced the desflurane requirement by 26% compared to the control group (P < 0.01). In addition, the AEP-monitored group received less intraoperative fentanyl (270 +/- 120 vs. 390 +/- 203 microg, P < 0.05) and more rapidly achieved fast-track eligibility (29 +/- 19 vs. 56 +/- 41 min, P < 0.05). The time required to achieve an Aldrete score of 10 (60 +/- 31 vs. 98 +/- 55 min) and the duration of stay in the recovery room (78 +/- 32 vs. 106 +/- 54 min) were also significantly reduced in the AEP-monitored (vs. control) group (P < 0.05). Conclusion Use of AEP monitoring as an adjunct to standard clinical monitors improved titration of anesthetic drugs, thereby facilitating the early recovery process after laparoscopic surgery.
31
Padrón, Andrés Santiago, Jared Thomas, Andrew P. J. Stanley, Juan J. Alonso, and Andrew Ning. "Polynomial chaos to efficiently compute the annual energy production in wind farm layout optimization." Wind Energy Science 4, no. 2 (May 8, 2019): 211–31. http://dx.doi.org/10.5194/wes-4-211-2019.
Full textAbstract:
Abstract. In this paper, we develop computationally efficient techniques to calculate statistics used in wind farm optimization with the goal of enabling the use of higher-fidelity models and larger wind farm optimization problems. We apply these techniques to maximize the annual energy production (AEP) of a wind farm by optimizing the position of the individual wind turbines. The AEP (a statistic) is the expected power produced by the wind farm over a period of 1 year subject to uncertainties in the wind conditions (wind direction and wind speed) that are described with empirically determined probability distributions. To compute the AEP of the wind farm, we use a wake model to simulate the power at different input conditions composed of wind direction and wind speed pairs. We use polynomial chaos (PC), an uncertainty quantification method, to construct a polynomial approximation of the power over the entire stochastic space and to efficiently (using as few simulations as possible) compute the expected power (AEP). We explore both regression and quadrature approaches to compute the PC coefficients. PC based on regression is significantly more efficient than the rectangle rule (the method most commonly used to compute the expected power). With PC based on regression, we have reduced on average by a factor of 5 the number of simulations required to accurately compute the AEP when compared to the rectangle rule for the different wind farm layouts considered. In the wind farm layout optimization problem, each optimization step requires an AEP computation. Thus, the ability to compute the AEP accurately with fewer simulations is beneficial as it reduces the cost to perform an optimization, which enables the use of more computationally expensive higher-fidelity models or the consideration of larger or multiple wind farm optimization problems. We perform a large suite of gradient-based optimizations to compare the optimal layouts obtained when computing the AEP with polynomial chaos based on regression and the rectangle rule. We consider three different starting layouts (Grid, Amalia, Random) and find that the optimization has many local optima and is sensitive to the starting layout of the turbines. We observe that starting from a good layout (Grid, Amalia) will, in general, find better optima than starting from a bad layout (Random) independent of the method used to compute the AEP. For both PC based on regression and the rectangle rule, we consider both a coarse (∼225) and a fine (∼625) number of simulations to compute the AEP. We find that for roughly one-third of the computational cost, the optimizations with the coarse PC based on regression result in optimized layouts that produce comparable AEP to the optimized layouts found with the fine rectangle rule. Furthermore, for the same computational cost, for the different cases considered, polynomial chaos finds optimal layouts with 0.4 % higher AEP on average than those found with the rectangle rule.
32
Pryor, Sara C., Tristan J. Shepherd, and Rebecca J. Barthelmie. "Interannual variability of wind climates and wind turbine annual energy production." Wind Energy Science 3, no. 2 (September 24, 2018): 651–65. http://dx.doi.org/10.5194/wes-3-651-2018.
Full textAbstract:
Abstract. The interannual variability (IAV) of expected annual energy production (AEP) from proposed wind farms plays a key role in dictating project financing. IAV in preconstruction projected AEP and the difference in 50th and 90th percentile (P50 and P90) AEP derive in part from variability in wind climates. However, the magnitude of IAV in wind speeds at or close to wind turbine hub heights is poorly defined and may be overestimated by assuming annual mean wind speeds are Gaussian distributed with a standard deviation (σ) of 6 %, as is widely applied within the wind energy industry. There is a need for improved understanding of the long-term wind resource and the IAV therein in order to generate more robust predictions of the financial value of a wind energy project. Long-term simulations of wind speeds near typical wind turbine hub heights over the eastern USA indicate median gross capacity factors (computed using 10 min wind speeds close to wind turbine hub heights and the power curve of the most common wind turbine deployed in the region) that are in good agreement with values derived from operational wind farms. The IAV of annual mean wind speeds at or near typical wind turbine hub heights in these simulations and AEP computed using the power curve of the most commonly deployed wind turbine is lower than is implied by assuming σ=6 %. Indeed, rather than 9 out of 10 years exhibiting AEP within 0.9 and 1.1 times the long-term mean AEP as implied by assuming a Gaussian distribution with σ of 6 %, the results presented herein indicate that in over 90 % of the area in the eastern USA that currently has operating wind turbines, simulated AEP lies within 0.94 and 1.06 of the long-term average. Further, the IAV of estimated AEP is not substantially larger than IAV in mean wind speeds. These results indicate it may be appropriate to reduce the IAV applied to preconstruction AEP estimates to account for variability in wind climates, which would decrease the cost of capital for wind farm developments.
33
de Jesus Menezes-Filho, Noélio, Cleide dos Santos Souza, Tereza Cristina Silva Costa, Victor Diógenes Amaral da Silva, Cátia Suse de Oliveira Ribeiro, Marizeth Liborio Barreiros, Jose Fernando Oliveira Costa, Jorge Mauricio David, Juceni P. L. David, and Silvia Lima Costa. "Cytotoxicity of the Diterpene 14-O-Methyl-ryanodanol from Erythroxylum passerinum in an Astrocytic Cells Model." Natural Product Communications 9, no. 9 (September 2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900906.
Full textAbstract:
Plant secondary metabolites, such as, specifically, alkaloids and terpenes, may present psychoactive properties that modify the function of the central nervous system (CNS) and induce neurotoxicity. Neurotoxicity involves the response of glial cells, mainly astrocytes, which play a fundamental role in the control of homeostasis of the CNS. Some Erythroxylum species are indigenous to the state of Bahia in Brazil. This study investigated the cytotoxic activity of the diterpene AEP-1, extracted from the fruit of E. passerinum in a GL-15 cell line, astrocytic, glial cells model. The effects on cell viability, analyzed by the MTT assay, demonstrated a dose-dependent cytotoxic effect, with maximum effect at 500 μg/mL of AEP-1, and with a reduction of about 40 and 47% on cellular viability after 24 h and 72 h treatment, respectively. Evidence for induction of apoptosis by AEP-1 was first obtained when GL-15 glial cells were incubated with 250 μg/mL AEP-1 causing reniform and/or pyknotic nuclei and apoptotic bodies revealed by chromatin staining with Hoechst 33258. Increase in DNA fragmentation was also observed by comet assays in cells incubated with 500 μg/mL of AEP-1. Moreover, cells exposed to a sub toxic dose of AEP-1 (250 μg/mL) showed significant changes in morphology – contraction of the cytoplasm and expansion of cellular projections – signifying the presence of astrocytic cytoskeletal protein and glial fibrillary acidic protein (GFAP). These findings indicated astrocytic cells as the target for terpene AEP-1 and suggest the involvement of glial cells with psychoactive symptoms observed in humans and animals after consumption of fruits of plants of the genus Erythroxylum.
34
Bodini, Nicola, and Mike Optis. "Operational-based annual energy production uncertainty: are its components actually uncorrelated?" Wind Energy Science 5, no. 4 (October 31, 2020): 1435–48. http://dx.doi.org/10.5194/wes-5-1435-2020.
Full textAbstract:
Abstract. Calculations of annual energy production (AEP) from a wind power plant – whether based on preconstruction or operational data – are critical for wind plant financial transactions. The uncertainty in the AEP calculation is especially important in quantifying risk and is a key factor in determining financing terms. A popular industry practice is to assume that different uncertainty components within an AEP calculation are uncorrelated and can therefore be combined as the sum of their squares. We assess the practical validity of this assumption for operational-based uncertainty by performing operational AEP estimates for more than 470 wind plants in the United States, mostly in simple terrain. We apply a Monte Carlo approach to quantify uncertainty in five categories: revenue meter data, wind speed data, regression relationship between density-corrected wind speed (from reanalysis data) and measured wind power, length of long-term-correction data set, and future interannual variability. We identify correlations between categories by comparing the results across all 470 wind plants. We observe a positive correlation between interannual variability and the linearized long-term correction; a negative correlation between wind resource interannual variability and linear regression; and a positive correlation between reference wind speed uncertainty and linear regression. Then, we contrast total operational AEP uncertainty values calculated by omitting and considering correlations between the uncertainty components. We quantify that ignoring these correlations leads to an underestimation of total AEP uncertainty of, on average, 0.1 % and as large as 0.5 % for specific sites. Although these are not large increases, these would still impact wind plant financing rates; further, we expect these values to increase for wind plants in complex terrain. Based on these results, we conclude that correlations between the identified uncertainty components should be considered when computing the total AEP uncertainty.
35
McFadden, Dennis, Craig A. Champlin, Michelle H. Pho, Edward G. Pasanen, Mindy M. Maloney, and Erin M. Leshikar. "Auditory evoked potentials: Differences by sex, race, and menstrual cycle and correlations with common psychoacoustical tasks." PLOS ONE 16, no. 5 (May 12, 2021): e0251363. http://dx.doi.org/10.1371/journal.pone.0251363.
Full textAbstract:
Auditory brainstem responses (ABRs) and auditory middle-latency responses (AMLRs) to a click stimulus were measured in about 100 subjects. Of interest were the sex differences in those auditory evoked potentials (AEPs), the correlations between the various AEP measures, and the correlations between the AEP measures and measures of otoacoustic emissions (OAEs) and behavioral performance also measured on the same subjects. Also of interest was how the menstrual cycle affected the various AEP measures. Most ABR measures and several AMLR measures exhibited sex differences, and many of the former were substantial. The sex differences tended to be larger for latency than for amplitude of the waves, and they tended to be larger for a weak click stimulus than for a strong click. The largest sex difference was for Wave-V latency (effect size ~1.2). When subjects were dichotomized into Non-Whites and Whites, the race differences in AEPs were small within sex. However, sex and race interacted so that the sex differences often were larger for the White subjects than for the Non-White subjects, particularly for the latency measures. Contrary to the literature, no AEP measures differed markedly across the menstrual cycle. Correlations between various AEP measures, and between AEP and OAE measures, were small and showed no consistent patterns across sex or race categories. Performance on seven common psychoacoustical tasks was only weakly correlated with individual AEP measures (just as was true for the OAEs also measured on these subjects). AMLR Wave Pa unexpectedly did not show the decrease in latency and increase in amplitude typically observed for AEPs when click level was varied from 40 to 70 dB nHL (normal Hearing Level). For the majority of the measures, the variability of the distribution of scores was greater for the males than for the females.
36
Möllerström, Erik, Sean Gregory, and Aromal Sugathan. "Improvement of AEP Predictions with Time for Swedish Wind Farms." Energies 14, no. 12 (June 11, 2021): 3475. http://dx.doi.org/10.3390/en14123475.
Full textAbstract:
Based on data from 2083 wind turbines installed in Sweden from 1988 onwards, the accuracy of the predictions of the annual energy production (AEP) from the project planning phases has been compared to the actual wind-index-corrected production. Both the electricity production and the predicted AEP come from Vindstat, a database that collects information directly from wind turbine owners. The mean error for all analyzed wind turbines was 13.0%, which means that, overall, the predicted AEP has been overestimated. There has been an improvement of accuracy with time with an overestimation of 8.2% for wind turbines installed in the 2010s, however, the continuous improvement seems to have stagnated around 2005 despite better data availability and continuous refinement of methods. Dividing the results by terrain, the error is larger for wind turbines in open and flat terrain than in forest areas, indicating that the reason behind the error is not the higher complexity of the forest terrain. Also, there is no apparent increase of error with wind farm size which could have been expected if wind farm blockage effect was a main reason for the overestimations. Besides inaccurate AEP predictions, a higher-than-expected performance decline due to inadequate maintenance of the wind turbines may be a reason behind the AEP overestimations. The main sources of error are insecurity regarding the source of AEP predictions and the omission of mid-life alterations of rated power.
37
Ezekwudo, Daniel E., Rohit Singh, Bolanle Gbadamosi, Mark Micale, Ishmael Jaiyesimi, and Marc Smith. "Prognostic Impact of Bone Marrow Erythropoiesis on Newly Diagnosed Plasma Cell Myeloma: A Single Institutional Analyses." Blood 132, Supplement 1 (November 29, 2018): 5579. http://dx.doi.org/10.1182/blood-2018-99-116619.
Full textAbstract:
Abstract Introduction: In plasma cell myeloma (PCM), tumor burden and activity plays an important role in diagnosis and prognosis (e.g. circulating plasma cells), however very little attention has been directed to the impact of the non-plasma cell component of the bone marrow. The presence of anemia has been used to distinguish PCM from smoldering myeloma; however this can be a non-specific finding as there are many potential causes of anemia besides PCM. We sought to determine if the level of erythropoiesis in bone marrow biopsies may be a more reliable prognostic factor. In the study herein, we assessed the level of bone marrow erythropoiesis in patients with newly diagnosed PCM, and compared those findings with cytogenetic results (CGs), other prognostic factors and overall clinical outcome. We hypothesized that patients with adequate erythropoiesis (AEp) are likely to have favorable cytogenetics and better outcome compared to those with decreased erythropoiesis (DEp). Methods: We retrospectively reviewed pathology database for bone marrow biopsies in patients with diagnosis of plasma cell myeloma (PCM) at Beaumont Hospital, an academic community center from 2012 and 2014. Biopsy cases without anemia were excluded. A total of 91 patients with plasma cell myeloma and anemia were identified. Each biopsy was re-examined to determine the level of erythropoiesis. The level of erythropoiesis was calculated by multiplying erythroid fraction (obtained from M:E ratio) with non-plasma cell bone marrow cellularity. Cases were separated into AEp and DEp using an erythroid compartment cut-off of 7.5% based on already established data. Kaplan-Meier analysis was used to compare survival between groups. Results: Demographic distribution of studied patients were 46 (50.1%) white, 39 (43%) African Americans and 6 (6.6%) others. Out of 91 cases analyzed, 38 (42%) had AEp whereas 53 (58%) had DEp. Among those with AEp, 23 (62%) had favorable CGs (defined as those without t (4, 14), t (14, 16), t (14, 20) or 17 p deletion); 15 (38%) had unfavorable CGs. Among those with DEp, 14 (26%) had favorable CGs whereas 39 (74%) had unfavorable cytogenetics. The vast majority of patients with favorable CGs were alive whether they had AEp (87%) or DEp (79%), thus CGs remained significant even after controlling for erythroid compartment (p = 0.03). Overall, those with AEp were noted to have significantly lower β-2 microglobulin (AEp median =2.42 mg/dL, DEp median = 4.50 mg/dL, p = 0.02). Kaplan-Meier analysis showed a significant difference in survival curves among the four groups (AEp with favorable CGs, AEp with unfavorable CGs, DEp with favorable CGs, DEp with unfavorable CGs, p<.0001). While the two groups with favorable CGs showed no significant difference (p=.6050), the two groups with unfavorable CGs did (p=.0027). Conclusion: Our findings suggest that patients with PCM and anemia are not a homogenous population. Assessment of the erythroid compartment in these patients reveals a population with AEp that has more favorable CGs and lower β-2 microglobulin than patients with DEp. Despite this finding, patients with favorable CGs had a favorable clinical outcome whether they had AEp or not, indicating that current therapies can overcome differences in erythropoiesis in that group. For patients with unfavorable CGs, however, those with AEp had superior survival outcome compared to those with DEp, indicating that there may be some prognostic or diagnostic utility to assessing erythropoiesis in patients who meet current criteria for PCM, and possibly, incorporating erythropoietic activity into diagnostic/prognostic schema. Disclosures No relevant conflicts of interest to declare.
38
Ferraro, John A., John D. Durrant, Yvonne S. Sininger, and Kathleen Campbell. "Recommended Guidelines for Reporting AEP Specifications." American Journal of Audiology 5, no. 3 (November 1996): 35–37. http://dx.doi.org/10.1044/1059-0889.0503.35.
Full text
39
Renz, B. A., A. Keri, A. S. Mehraban, C. Schauder, E. Stacey, L. Kovalsky, L. Gyugyi, and A. Edris. "AEP unified power flow controller performance." IEEE Transactions on Power Delivery 14, no. 4 (1999): 1374–81. http://dx.doi.org/10.1109/61.796231.
Full text
40
Litvan, Héctor, Erik W. Jensen, Josefina Galan, Jeppe Lund, Bernardo E. Rodriguez, Steen W. Henneberg, Pere Caminal, and Juan M. Villar Landeira. "Comparison of Conventional Averaged and Rapid Averaged, Autoregressive-based Extracted Auditory Evoked Potentials for Monitoring the Hypnotic Level during Propofol Induction." Anesthesiology 97, no. 2 (August 1, 2002): 351–58. http://dx.doi.org/10.1097/00000542-200208000-00011.
Full textAbstract:
Background The extraction of the middle latency auditory evoked potentials (MLAEP) is usually done by moving time averaging (MTA) over many sweeps (often 250-1,000), which could produce a delay of more than 1 min. This problem was addressed by applying an autoregressive model with exogenous input (ARX) that enables extraction of the auditory evoked potentials (AEP) within 15 sweeps. The objective of this study was to show that an AEP could be extracted faster by ARX than by MTA and with the same reliability. Methods The MTA and ARX methods were compared with the Modified Observer's Assessment of Alertness and Sedation Scale (MOAAS) in 15 patients scheduled for cardiac surgery and anesthetized with propofol. The peak amplitudes and latencies were recorded continuously for the MTA- and ARX-extracted AEP. An index, AAI, was derived from the ARX-extracted AEP as well. Results The best predictors of the awake and anesthetized states, in terms of the prediction probability, Pk, were the AAI (Pk [SE] = 0.93 [0.01]) and Na-Pa amplitude (MTA, Pk [SE] = 0.89 [0.02]; ARX, Pk [SE] = 0.87[0.02]). When comparing the AAI at the MOAAS levels 5-3 versus 2-0, significant differences were achieved. During the transitions from awake to asleep, the ARX-extracted AEP were obtained with significantly less delay than the MTA-extracted AEP (28.4 s vs. 6 s). Conclusion The authors conclude that the MLAEP peaks and the AAI correlate well to the MOAAS, whether extracted by MTA or ARX, but the ARX method produced a significantly shorter delay than the MTA.
41
Munusamy, M. Miandy, and Azirah Hashim. "The ASEM Education Process: Implications for higher education internationalization in Malaysia." AEI Insights: An International journal of Asia-Europe relations 7, no. 1 (January 30, 2021): 19–35. http://dx.doi.org/10.37353/aei-insights.vol7.issue1.2.
Full textAbstract:
The education process of the Asia-Europe Meeting (ASEM) has played an important role in higher education internationalisation since the establishment of ASEM in Bangkok, Thailand in 1996. The ASEM Education Process (AEP) consists of 53 ASEM partners and more than 15 ASEM education stakeholders who meet regularly for discussions on policies and reform measures. There are four priority areas and two transversal themes introduced in the AEP for policy direction and strategy implementation in the field of higher education. Malaysia has participated in the AEP since 2008 and has led and organised various initiatives and meetings on the internationalisation of higher education and global recognition. This study aims to explore the implications of the AEP for the process of internationalisation of higher education in Malaysia. A qualitative study with semi-structured interviews was conducted with fifteen senior officers of the Ministry of Higher Education, Malaysia and five Malaysian research universities. The data were analysed by employing the Qualitative Data Analysis software, the Nvivo version 11, to identify themes and categories. The findings reveal that the AEP can play a major role in internationalising Malaysian higher education through effective networking and strategic alliances. The four priority areas of the AEP has provided opportunities for Malaysia to work closely with European and Asian counterparts in the field of higher education. The findings can assist the Malaysian higher education stakeholder to participate actively in the inter-regional organisation to learn and share best practices and to formulate and revise policies on higher education internationalisation.
42
Shrestha, Umit, Jessica Hanson, Tess Weber, and Karen Ingersoll. "Community Perceptions of Alcohol Exposed Pregnancy Prevention Program for American Indian and Alaska Native Teens." International Journal of Environmental Research and Public Health 16, no. 10 (May 21, 2019): 1795. http://dx.doi.org/10.3390/ijerph16101795.
Full textAbstract:
A community needs assessment during a tribally-led Changing High-Risk Alcohol Use and Increasing Contraception Effectiveness Study (CHOICES) intervention highlighted the need to reduce the risk for alcohol exposed pregnancy (AEP) among American Indian and Alaska Native (AIAN) adolescent girls. The CHOICES for American Indian Teens (CHAT) Program aims to reduce the risk of AEP among AIAN teens in one Northern Plains tribal community. The CHAT team adopted an iterative process to modify the tribally-led CHOICES curriculum for AIAN teens. This paper describes the iterative process as well as the community perception towards AEP prevention among AIAN teens. The CHAT team conducted several levels of formative and qualitative research, including one-on-one interviews (n = 15) with community members, AIAN elders and school counsellors; and three focus groups with AIAN adolescent girls (n = 15). A qualitative data analysis identified several recommendations that centered on making the information regarding alcohol and birth control appealing to teens; ensuring the confidentiality of the participants; making the program culturally relevant; and including boys in the program. This study outlines various components prioritized by community members in creating a culturally-relevant and age-appropriate AEP prevention program and provides community perceptions of AEP prevention for the teens in this community
43
Carvalho, Elias De, and Valdes Roberto Bollela. "Agendamento eletrônico do paciente (AEP) como ferramenta de gestão dos ambulatórios de um serviço de referência terciária em saúde." Revista Eletronica Gestão & Saúde 6, no. 2 (March 16, 2015): 1446. http://dx.doi.org/10.18673/gs.v6i2.22479.
Full textAbstract:
Objetivo: Avaliar a funcionalidade e indicadores gerados pelo sistema de Agendamento Eletrônico do Paciente (AEP) na gestão da assistência e ensino nos ambulatórios de um hospital terciário de ensino descrevendo o processo e suas potencialidades e o potencial impacto destas informações no processo de gestão ambulatorial. Metodologia: Estudo descritivo e exploratório do AEP e seus indicadores, caracterizado como pesquisa-ação. Foram aplicados questionários semi-estruturados para avaliar a percepção dos usuários do sistema e realizado análise quali-quantitativa dos resultados obtidos. Resultados: Foi realizada a descrição do AEP e seu ganho quando comparado com o modelo tradicional de agendamento em papel. A implantação do AEP possibilitou acesso rápido aos dados e sua utilização como ferramenta para gestão e tomada de decisão em termos assistenciais e de ensino. Estas informações têm potencial para embasar a revisão e melhoria dos processos de atendimento em um ambulatório com mais de 200 consultórios.. Entretanto, muitos médicos assistentes e professores ainda não compreenderam o potencial desta ferramenta na gestão da assistência e ensino no hospital. Conclusão: O AEP é uma ferramenta importante para agilizar a revisão e melhoria dos processos de gestão do ambulatório, mas será preciso treinar as equipes de saúde visando ampliar seu uso no hospital. Palavras Chaves: Humanização da Assistência, Gestão Hospitalar, Gestão em Saúde.
44
Khoyi, M. A., S. M. Bowen, and K. D. Keef. "Effect of membrane potential on H1-receptor-mediated 45Ca influx in coronary artery." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 2 (August 1, 1991): H554—H560. http://dx.doi.org/10.1152/ajpheart.1991.261.2.h554.
Full textAbstract:
These studies were undertaken to determine whether agonist-induced 45Ca influx in the coronary artery is modified under conditions in which Na+ pump activity (and consequently membrane potential) is altered. 45Ca influx and contraction were measured in the rabbit coronary artery with the H1-receptor agonist 2-(2-aminoethyl)pyridine (AEP, 10(-4) M) after prolonged Na+ pump block (leading to profound depolarization) and after enhanced Na+ pump activity (leading to hyperpolarization). AEP contracted vessels, enhanced 45Ca influx into the smooth muscle, and increased 45Ca efflux. The AEP-induced contraction was reduced but not abolished with either nifedipine (10(-6) M) or Ca(2+)-free solution. In tissues subjected to prolonged Na+ pump block AEP caused contraction but 45Ca influx was not increased over the unstimulated tissue. Ca(2+)-free solution and nifedipine reduced but did not abolish these contractions. In tissues with enhanced Na+ pump activity AEP caused contraction but 45Ca influx was not increased. Ca(2+)-free solution reduced these contractions but nifedipine did not. We conclude that the measurable 45Ca influx changes in a manner that is compatible with the characteristics of voltage-gated Ca2+ channels that have a low open probability during hyperpolarization and are inactivated by a period of long slow depolarization.
45
Freitas, Cristina Setim, Cristiane Hatsuko Baggio, Samanta Luiza Araújo, and Maria Consuelo Andrade Marques. "Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers." Brazilian Archives of Biology and Technology 51, no. 4 (August 2008): 479–83. http://dx.doi.org/10.1590/s1516-89132008000400005.
Full textAbstract:
The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.
46
Siqueira, W. L., W. Custodio, and E. E. McDonald. "New Insights into the Composition and Functions of the Acquired Enamel Pellicle." Journal of Dental Research 91, no. 12 (September 26, 2012): 1110–18. http://dx.doi.org/10.1177/0022034512462578.
Full textAbstract:
The acquired enamel pellicle (AEP) is a thin acellular film that forms on tooth surfaces upon exposure to the oral environment. It consists predominantly of salivary proteins, but also includes non-salivary-derived proteins, carbohydrates, and lipids. Since it is the interface between teeth and the oral environment, the AEP plays a key role in the maintenance of oral health by regulating processes including lubrication, demineralization, and remineralization and shaping the composition of early microbial flora adhering to tooth surfaces. Knowledge of the 3D structure of the AEP and how that correlates with its protective functions may provide insight into several oral pathological states, including caries, erosion, and periodontal disease. This review intends to update readers about the latest discoveries related to the formation, ultrastructure, composition, and functions of the AEP, as well as the future of pellicle research, with particular emphasis on the emerging role of proteomic and microscopy techniques in oral diagnosis and therapeutics.
47
Jin, Jia Yi, Rizwan Ghani, and Muhammad S. Virk. "Wind Turbine Wake Effects on Wind Resource Assessments – a Case Study." E3S Web of Conferences 186 (2020): 03003. http://dx.doi.org/10.1051/e3sconf/202018603003.
Full textAbstract:
This paper describes a case study of wind turbine wake loss effects on wind resource assessment in cold region. One year wind park SCADA data is used. Computational Fluid Dynamics (CFD) based numerical simulations are carried out for wind resource assessment and estimation of resultant Annual Energy Production (AEP). Numerical results are compared with the field SCADA data, where a good agreement is found. To better understand the wind flow physics and effects of wind turbine turbulence wake loss effects, three different wake loss models are used for the numerical simulations, where results with wake model is found in best agreement with the AEP estimation from field SCADA data. A detailed comparison of all wind turbines is also presented with the gross AEP. A preliminary case study about wind park layout optimization has also been carried out which shows that AEP can be improved by optimizing the wind park layout and CFD simulations can be used as a tool in this regards.
48
Franco, Valentina, Maria Paola Canevini, Giovambattista De Sarro, Cinzia Fattore, Guido Fedele, Carlo Andrea Galimberti, Giuliana Gatti, et al. "Does screening for adverse effects improve health outcomes in epilepsy?" Neurology 95, no. 3 (June 29, 2020): e239-e246. http://dx.doi.org/10.1212/wnl.0000000000009880.
Full textAbstract:
ObjectiveTo determine whether systematic screening for adverse effects of antiepileptic drugs (AEDs) reduces toxicity burden and improves health-related quality of life in patients with epilepsy.MethodsConsecutive patients with uncontrolled seizures aged ≥16 years and a high Adverse Event Profile (AEP) score were randomized to 2 groups and followed up for 18 months at 11 referral centers. AEP scores were made available to treating physicians at all visits in the intervention group, but not in the control group. Co–primary endpoints were changes in AEP scores and Quality of Life Inventory for Epilepsy-31 (QOLIE–31) scores.ResultsOf 809 enrolled patients able to complete the AEP questionnaire, 222 had AEP scores ≥45 and were randomized to the intervention (n = 111) or control group (n = 111). A total of 206 patients completed the 18-month follow-up. Compared with baseline, AEP scores decreased on average by 7.2% at 6 months, 12.1% at 12 months, and 13.8% at 18 months in the intervention group (p < 0.0001), and by 7.7% at 6 months, 9.2% at 12 months, and 12.0% at 18 months in controls (p < 0.0001). QOLIE-31 scores also improved from baseline to final visit, with a mean 20.7% increase in the intervention group and a mean 24.9% increase in the control group (p < 0.0001). However, there were no statistically significant differences in outcomes between groups for the 2 co–primary variables.ConclusionsContrary to findings from a previous study, systematic screening for adverse effects of AEDs using AEP scores did not lead to a reduced burden of toxicity over usual physician treatment.Italian Medicines Agency (AIFA) identifierFARM52K2WM_003.Clinicaltrials.gov identifierNCT03939507 (registered retrospectively in 2019; the study was conducted during the 2006–2009 period and registration of clinical trials was not a widely established practice when this study was initiated).Classification of evidenceThis study provides Class II evidence that the additional collection of formal questionnaires regarding adverse effects of AEDs does not reduce toxicity burden over usual physician treatment.
49
Schneider, Gerhard, Regina Hollweck, Michael Ningler, Gudrun Stockmanns, and Eberhard F. Kochs. "Detection of Consciousness by Electroencephalogram and Auditory Evoked Potentials." Anesthesiology 103, no. 5 (November 1, 2005): 934–43. http://dx.doi.org/10.1097/00000542-200511000-00006.
Full textAbstract:
Background A set of electroencephalographic and auditory evoked potential (AEP) parameters should be identified that allows separation of consciousness from unconsciousness (reflected by responsiveness/unresponsiveness to command). Methods Forty unpremedicated patients received anesthesia with remifentanil and either sevoflurane or propofol. With remifentanil infusion (0.2 microg . kg . min), patients were asked every 30 s to squeeze the investigator's hand. Sevoflurane or propofol was given until loss of consciousness. After intubation, propofol or sevoflurane was stopped until patients followed the command (return of consciousness). Thereafter, propofol or sevoflurane was started again (loss of consciousness), and surgery was performed. Return of consciousness was observed after surgery. The electroencephalogram and AEP from immediately before and after the transitions were selected. Logistic regression was calculated to identify models for the separation between consciousness and unconsciousness. For the top 10 models, 1,000-fold cross-validation was performed. Backward variable selection was applied to identify a minimal model. Prediction probability was calculated. The digitized electroencephalogram was replayed, and the Bispectral Index was measured and accordingly analyzed. Results The best full model (prediction probability 0.89) contained 15 AEP and 4 electroencephalographic parameters. The best minimal model (prediction probability 0.87) contained 2 AEP and 2 electroencephalographic parameters (median frequency of the amplitude spectrum from 8-30 Hz and approximate entropy). The prediction probability of the Bispectral Index was 0.737. Conclusions A combination of electroencephalographic and AEP parameters can be used to differentiate between consciousness and unconsciousness even in a very challenging data set. The minimal model contains a combination of AEP and electroencephalographic parameters and has a higher prediction probability than Bispectral Index for the separation between consciousness and unconsciousness.
50
Ankermann, Tobias. "Die ambulant erworbene Pneumonie im Kindesalter." Kinder- und Jugendmedizin 6, no. 03 (2006): 139–44. http://dx.doi.org/10.1055/s-0037-1617901.
Full textAbstract:
ZusammenfassungDer Begriff „ambulant erworbene Pneumonie (AEP)” beschreibt die Entzündung des Lungenparenchyms eines zuvor gesunden Individuums durch einen Erreger, der außerhalb eines Krankenhauses vom Individuum aufgenommen wurde. Die AEP hat bei Kindern in Europa und Nordamerika eine Inzidenz von 3000–4000 Erkrankungen pro 100 000 Einwohner und Jahr. Bei rund 55% der Fälle ist eine bakterielle Infektion ätiologisch zumindest mitbeteiligt. Bei der ambulanten Betreuung ist die klinische Diagnosestellung entscheidend. Röntgendiagnostik und Labordiagnostik haben bei schwereren Verlaufsformen eine Bedeutung. Bei vermuteter bakterieller Ätiologie einer AEP ist ein oral applizierbares Penicillin Mittel der ersten Wahl. Zur Prävention sind die Bekämpfung von Hunger, hygienische Maßnahmen und Impfungen möglich.