Relevant bibliographies by topics / Advanced drug delivery systems

Academic literature on the topic 'Advanced drug delivery systems'

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Published: 10 March 2023

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Journal articles on the topic "Advanced drug delivery systems"

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Alallam, Batoul, Hazem Choukaife, Salma Seyam, Vuanghao Lim, and Mulham Alfatama. "Advanced Drug Delivery Systems for Renal Disorders." Gels 9, no. 2 (February 1, 2023): 115. http://dx.doi.org/10.3390/gels9020115.

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Kidney disease management and treatment are currently causing a substantial global burden. The kidneys are the most important organs in the human urinary system, selectively filtering blood and metabolic waste into urine via the renal glomerulus. Based on charge and/or molecule size, the glomerular filtration apparatus acts as a barrier to therapeutic substances. Therefore, drug distribution to the kidneys is challenging, resulting in therapy failure in a variety of renal illnesses. Hence, different approaches to improve drug delivery across the glomerulus filtration barrier are being investigated. Nanotechnology in medicine has the potential to have a significant impact on human health, from illness prevention to diagnosis and treatment. Nanomaterials with various physicochemical properties, including size, charge, surface and shape, with unique biological attributes, such as low cytotoxicity, high cellular internalization and controllable biodistribution and pharmacokinetics, have demonstrated promising potential in renal therapy. Different types of nanosystems have been employed to deliver drugs to the kidneys. This review highlights the features of the nanomaterials, including the nanoparticles and corresponding hydrogels, in overcoming various barriers of drug delivery to the kidneys. The most common delivery sites and strategies of kidney-targeted drug delivery systems are also discussed.
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Riahi, Reza, Ali Tamayol, Seyed Ali Mousavi Shaegh, Amir M. Ghaemmaghami, Mehmet R. Dokmeci, and Ali Khademhosseini. "Microfluidics for advanced drug delivery systems." Current Opinion in Chemical Engineering 7 (February 2015): 101–12. http://dx.doi.org/10.1016/j.coche.2014.12.001.

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Bordbar-Khiabani, Aydin, and Michael Gasik. "Smart Hydrogels for Advanced Drug Delivery Systems." International Journal of Molecular Sciences 23, no. 7 (March 27, 2022): 3665. http://dx.doi.org/10.3390/ijms23073665.

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.
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Arshad, Shumaila, Ali Aun, and Muhammad Uzair Yousaf. "Drug Delivery System in Pakistan: A Review." Research in Pharmacy and Health Sciences 2, no. 3 (August 15, 2016): 174–78. http://dx.doi.org/10.32463/rphs.2016.v02i03.35.

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Drug Delivery systems are the means by which drug molecules are delivered to sites of action within the body.There are several pharmaceutical dosage forms (delivery Systems) available in Pakistan that is being used in different health care centers. Both conventional and advance dosage forms are used now days depending upon the condition of the patient, the disease state and available resources. But unfortunately Pakistan is a way behind in the field of technology among the other developing and developed countries in the world. There are few private setups which are well equipped with high class technology that caters the need of advanced drug delivery system in Pakistan. Mostly advanced drug dosage forms are imported from the other countries, thus it costs Pakistan a lot. In the present study Drug Delivery Systems in Pakistan is thoroughly studied and represented according to the generations of drug delivery system.
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Gorantla, Srividya, Tejashree Waghule, Vamshi Krishna Rapalli, Prem Prakash Singh, Sunil Kumar Dubey, Ranendra Narayan Saha, and Gautam Singhvi. "Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery." Recent Patents on Drug Delivery & Formulation 13, no. 4 (April 29, 2020): 291–300. http://dx.doi.org/10.2174/1872211314666200108094851.

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Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.
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Tang, Lu, Jing Li, Qingqing Zhao, Ting Pan, Hui Zhong, and Wei Wang. "Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery." Pharmaceutics 13, no. 8 (July 27, 2021): 1151. http://dx.doi.org/10.3390/pharmaceutics13081151.

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The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted.
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Shen, Haosheng, Nikhil Aggarwal, Kwok Soon Wun, Yung Seng Lee, In Young Hwang, and Matthew Wook Chang. "Engineered microbial systems for advanced drug delivery." Advanced Drug Delivery Reviews 187 (August 2022): 114364. http://dx.doi.org/10.1016/j.addr.2022.114364.

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Karimi, Mahdi, Sajad Bahrami, Soodeh Baghaee Ravari, Parham Sahandi Zangabad, Hamed Mirshekari, Mahnaz Bozorgomid, Somayeh Shahreza, Masume Sori, and Michael R. Hamblin. "Albumin nanostructures as advanced drug delivery systems." Expert Opinion on Drug Delivery 13, no. 11 (June 3, 2016): 1609–23. http://dx.doi.org/10.1080/17425247.2016.1193149.

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Greineder, Colin F., Melissa D. Howard, Ronald Carnemolla, Douglas B. Cines, and Vladimir R. Muzykantov. "Advanced drug delivery systems for antithrombotic agents." Blood 122, no. 9 (August 29, 2013): 1565–75. http://dx.doi.org/10.1182/blood-2013-03-453498.

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Abstract Despite continued achievements in antithrombotic pharmacotherapy, difficulties remain in managing patients at high risk for both thrombosis and hemorrhage. Utility of antithrombotic agents (ATAs) in these settings is restricted by inadequate pharmacokinetics and narrow therapeutic indices. Use of advanced drug delivery systems (ADDSs) may help to circumvent these problems. Various nanocarriers, affinity ligands, and polymer coatings provide ADDSs that have the potential to help optimize ATA pharmacokinetics, target drug delivery to sites of thrombosis, and sense pathologic changes in the vascular microenvironment, such as altered hemodynamic forces, expression of inflammatory markers, and structural differences between mature hemostatic and growing pathological clots. Delivery of ATAs using biomimetic synthetic carriers, host blood cells, and recombinant fusion proteins that are activated preferentially at sites of thrombus development has shown promising outcomes in preclinical models. Further development and translation of ADDSs that spare hemostatic fibrin clots hold promise for extending the utility of ATAs in the management of acute thrombotic disorders through rapid, transient, and targeted thromboprophylaxis. If the potential benefit of this technology is to be realized, a systematic and concerted effort is required to develop clinical trials and translate the use of ADDSs to the clinical arena.
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Sung, Hsing-Wen, and Zhuang Liu. "Advanced Drug Delivery Systems for Therapeutic Applications." Advanced Healthcare Materials 3, no. 8 (August 2014): 1130–32. http://dx.doi.org/10.1002/adhm.201400323.

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Dissertations / Theses on the topic "Advanced drug delivery systems"

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Shams, Talayeh. "Electrohydrodynamic processing for preparation of advanced drug delivery systems." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10060826/.

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This research explores the feasibility of the electrohydrodynamic processing using single and co-axial set-up as a single step processing tool for preparation of advanced drug delivery systems. A number of synthetic biodegradable and non-biodegradable polymers were used in order to prepare formulations incorporating drugs of different physicochemical characteristics. Based on the focus and the desired applications, the polymeric carrier and solvent system as well as the model drug of interest were selected to develop the drug delivery systems. Firstly, core-shell microparticles were prepared and optimized using co-axial electrohdrodynamic processing with precise control over the averaged particle size and size distribution. This was followed by integration of model drugs with different water-solubility. In this study, the release characteristics of the developed particles were investigated with single and simultaneous encapsulation of the drugs. Successful preparation of fixed dose combination formulation with high processing yield and encapsulation efficiency was reported. Secondly, single and co-axial electrohydrodynamic processing was utilized for preparation of smart drug delivery system for targeted release of prednisolone. Colon targeted drug delivery systems were developed using a pH-responsive polymer. Varying polymer drug ratio was applied to further enhance the release profiles and obtain an efficient delivery system whereby local delivery of prednisolone is made possible. Finally, microspheres were developed for co-encapsulation of anti-diabetic drugs with different water-solubility. The successfully developed sustained release formulations have the potential to overcome the existing limitations of conventional formulations by enhancing patient compliance and efficacy of the treatment of any chronic conditions.
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Saeed, Aram Omer. "Toward advanced modular drug and gene delivery system." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/27632/.

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In chapter two, the development of new a nanoparticulate carrier system for gene delivery was described. The new nanocarrier consists of a blend matrix formed by a poly (lactic-eo-glycolic acid) (PLGA) and Poly(ethylene glycol) bis (3-aminopropyl) terminated (also known as JeffamineTM). Nanopartic1es were formulated based on a 50:50 weight ratio of PLGA:Jeffamine using a modified emulsification-solvent diffusion technique. The potential of these blended matrix nanoparticles for encapsulation efficiency of Calf Thymus DNA and release profile were also studied. The achieved encapsulation efficiency of Calf Thymus DNA was approximately 84% for 0.4% theoretical loading with regard to total amount of PLGA. The PLGA: Jeffamine blended nanoparticles provided continuous and controlled release of Calf Thymus DNA. The PLGA:Jeffamine nanopartic1es were also coated with PLGA-PEGMA&75and PDMAEMA-PEGMA block copolymers using a simple physical adsorption method. After surface coating of the nanoparticles, zeta potential value showed significant reduction of surface charges from -38 mV to near zero value, while TEM micrographs showed a well defined core-shell nanoparticle. In chapter three, A facile route to biocompatible poly (lactic acid-coglycolic acid)-co-poly (ethyleneglycol methacrylate) (PLGA-PEGMA) block co-polymers was described utilising a combination of ring-opening polymerisation (ROP) and Radical Addition Fragmentation Transfer (RAFT) methods. A series of PLGA-PEGMA polymers varying in comonomer content and block length were synthesised with low polydispersities. All the block co-polymers formed micelles in aqueous solution as shown by dynamic light scattering, while critical micelle concentrations were found to be in the micromolar range. The polymer micelles were able to encapsulate model drugs(carboxyfluorescein and fluorescein isothiocyanate) and selected copolymer micelles incubated with 3T3 fibroblasts as a model cell line were rapidly taken up as indicated by fluorescence microscopy assays. The combination of the polymer chemistries opens the way to highly flexible syntheses of micellar drug carrier systems. In chapter four, multifunctional and modular block co-polymers prepared from biocompatible monomers and linked by a bioreducible disulphide linkage have been prepared using a combination of ring-opening and atom-transfer radical polymerizations (ATRP). The presence of terminal functionality via ATRP allowed cell-targeting folic acid groups to be attached in a controllable manner, while the block co-polymer architecture enabled well-defined nanopartic1es to be prepared by a water-oil-water double emulsion procedure to encapsulate DNA with high efficiency. Gene delivery assays in a Calu-3 cell line indicated specific folatereceptor-mediated uptake of the nanoparticles, and triggered release of the DNA payload via cleavage of the disulfide link resulted in enhanced transgene expression compared to non-bioreducible analogues. These materials offer a promising and generic means to deliver a wide variety of therapeutic payloads to cells in a selective and tuneable way.
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Sankaranarayanan, Thampi Sajeesh. "Development of advanced drug delivery systems based on polymethacrylic acid nano/microparticles for oral insulin delivery." Paris 11, 2010. http://www.theses.fr/2010PA114805.

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L’étude a portée sur le développement de micro- et nanoparticules polymères destinées à l’administration orale d’insuline. Une méthode de polymérisation radicalaire a été optimisée pour formuler des micro et des nanoparticules à base d’un polymère formant des hydrogels, le poly(acide de méthacrylique). Les particules ont ensuite été modifiées par greffage de résidus cystéine pour introduire des fonctions thiol en vue de renforcer les propriétés de bioadhésion et de promoteur d’adsorption des systèmes obtenus. Les particules ont montré des propriétés intéressantes de chargement en insuline et la libération se fait selon un mode de libération pH sensible. En effet, alors que l’insuline est majoritairement retenue dans la forme pharmaceutique à pH acide correspondant à un milieu gastrique, elle est libérée à un pH neutre voire légèrement basique retrouvé au niveau de l’intestin. Les systèmes ont montré une bonne capacité à améliorer le passage de l’épithélium intestinal sur des monocouches de cellules Caco 2 et sur de l’intestin isolé monté en chambres de Ussing. Au final, ces systèmes ont permis d’induire in vivo une réduction de la glycémie chez des animaux diabétiques et après une administration orale. Les essais menés sur des insulines modifiées ont permis d’identifier une stratégie de modification intéressante basée sur l’association de l’hormone à une cyclodextrine. En revanche, nos résultats suggèrent que la PEGylation de l’insuline n’apporte aucun bénéfice
The work carried out in this thesis was aimed to develop polymer micro- and nanoparticles for the oral administration of insulin. A method of radical polymerization was optimized to design micro and nanoparticles with a hydrogel forming polymer, poly(methacrylic acid) (PMAA). The particles were further modified by the grafting of cystein residues in order to introduce thiol functions which are believed to reinforce mucoadhesive and permeation enhancing properties of the formulation. The particles showed interesting loading properties for insulin and the release of the hormone was found to be pH dependent. Although insulin was mainly retained by the hydrogel particle in releasing medium mimicking the gastric environment, the hormone was released in conditions found in the intestine. The formulated systems have shown to improve the absorption of insulin through the intestinal mucosa in in vitro models including Caco 2 cell monolayers and the Ussing chambers. The microparticles selected from the in vitro experiments for in vivo studies have shown a capacity to deliver active insulin through the oral route to diabetic rats producing a reduction of the glycemia. Tests performed with modified insulin have allowed to identify that among the two strategies followed, this consisting on the association of insulin with a cyclodextrin was the most promising while the one based on the formation of an insulin-PEG conjugate did not brought any benefice
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Knop, Katrin [Verfasser], Ulrich Sigmar [Gutachter] Schubert, and Dagmar [Gutachter] Fischer. "Star-shaped drug delivery systems and advanced characterization by mass spectrometry / Katrin Knop ; Gutachter: Ulrich Sigmar Schubert, Dagmar Fischer." Jena : Friedrich-Schiller-Universität Jena, 2013. http://d-nb.info/1177641232/34.

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Shao, Huimin. "Development of an advanced drug delivery system to prevent and treat breast cancer bone metastasis." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/28640.

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Metastastic breast cancer is one of the leading causes of cancer death among women worldwide. Bone metastases occur most frequently among breast cancer patients that significantly influence the patients’ quality of life and reduce their survival rate. Among all types of breast cancer, triple negative breast cancer (TNBC) is more aggressive and more likely to develop metastasis. Thus, a targeted preventative modality is highly demanded for this unmet challenge. Nanoparticles have been under investigation for a few decades and have shown ample potential for the treatment of challenging types of cancer. The utilisation of nanoparticles can alter the drugs’ pharmacokinetics via different mechanisms, including improvement of the poor solubility of hydrophobic drugs and reduction of the metabolism. Curcumin, an active ingredient of the herb Curcuma longa rhizome, has been proven to have anticancer activity in various cancers. However, due to its low aqueous solubility and poor stability, the clinical application of curcumin in cancer treatment has been limited. In this research, in order to overcome the challenges associated with the poor druggability of curcumin, we designed and fabricated two different types of nanoparticles: Pluronic® F127-based micelles (with/without D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)) and poly (lactic-co-glycolic acid) (PLGA) -based polymeric nanoparticles (NPs) aiming at preventing and treating breast cancer bone metastasis. A main focus of this study was the development of hybrid untargeted, mono- and dual-targeted delivery systems for curcumin. With Pluronic® F127-based micelles, a major focus went to optimise the fabrication process of the F127-TPGS NPs. The optimised fabrication method for hybrid F127-TPGS resulted in a very high reproducibility after n>3 repeats leading to a consistent size 26.42 ± 0.57 nm, zeta-potential around 0.39 ± 0.99 mV, and PDI around 0.2. The drug loading (the amount of drug loaded per unit weight of the nanoparticle) was achieved at 3.80 ± 0.18% and encapsulation efficiency (the percentage of drug that is successfully entrapped into the nanoparticles) of 63.40 ± 3.00%. Bone targeted nanoparticles exhibited a high affinity to hydroxyapatite, the mineral bone matrix indicating bone targeting potentials of these NPs. In vitro cytotoxicity studies resulted in IC50 values at low micromolar range for all nanoparticles (ranging from 5-10 µM). We further studied the in vivo antitumour and anti-metastastic activity of untargeted and bone-targeted nanoparticles fabricated with Pluronic® F127 only. The results indicated that both types of nanoparticles could improve the overall condition of tumour burdened mice and inhibit the metastases to the liver, plausibly via prevention of the tumour angiogenesis. F127-coated PLGA-based bone-targeted nanoparticles showed size 168.00 ± 1.42 nm, zeta-potential -2.83 ± 0.22 mV, and PDI around 0.2. The loading was achieved at 0.97 ± 0.11% and encapsulation efficiency of 0.97 ± 0.11%. The results of In vitro cytotoxicity studies indicated that the alendronate conjugation in these NPs could significantly reduce the cell viability in human MDA-MB-231 TNBC cells compared to the negative control and untargeted nanoparticles (p<0.0001). In conclusion, the hybrid Pluronic® F127-TPGS based micelles had considerably smaller size than the F127-coated PLGA based NPs. Yet, both NP sizes lie within the acceptable size range for cancer therapy. All types of NPs showed great physical stability, and biocompatibility. They could solve the poor aqueous solubility of curcumin, in addition to exerting potent antitumour effect in vitro. The results indicated that the two types of NPs described in this research are promising carriers to be developed for the selective delivery of various poorly water-soluble drugs and have great potential for further investigation.
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Giménez, Morales Cristina. "Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/62822.

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[EN] The present PhD thesis, which is entitled "Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents" is focused on the development of new functional hybrid organic-inorganic materials for applications in the field of the controlled delivery of target molecules. The first chapter of the present thesis gives an introduction to the organic-inorganic hybrid materials functionalized with "molecular gates" and its application in controlled release processes. The second chapter of this thesis is focused on the development of a new nanodevice able to deliver its cargo as a function of the glucose concentration. The nanodevice is based on mesoporous silica nanoparticles loaded with a suitable fluorophore and functionalized with propylbenzymidazole moieties on the pore outlets. The mesopores are then capped with an active cyclodextrin modified glucose oxidase enzyme (through the formation of an inclusion complex between the cyclodextrins and the propylbenzymidazole group anchored to the solid support). When glucose is added its enzymatic oxidation produced gluconic acid. This acid induced a decrease in the pH of the medium and the protonation of the benzymidazole group that might result in the inclusion complex dethreading and the subsequent cargo release. The third chapter of the thesis is focused on the development of a new redox-responsive material for the controlled delivery of cytotoxic drugs in cancer cells. The system is based on mesoporous silica nanoparticles loaded with a reporter (safranin O) and functionalized with two different sized polyethylene glycol chains in the pore outlets using a disulfide linkage. In presence of glutathione, the disulfide bonds are cleaved allowing the release of the entrapped cargo. Once confirmed the aperture protocol, the uptake of the gated nanoparticles and their ability to deliver the cargo (fluorophore or cytotoxic agent) in HeLa cells were tested. Moreover, cell viability assays were also performed. The fourth chapter of the thesis is focused on the preparation and the study of a nanodevice for the controlled delivery in senescent cells in a murine model of pulmonary fibrosis. The material is prepared using mesoporous silica nanoparticles (as an inorganic support) and galactoligosaccharide (molecular gate) moieties anchored on the external surface. In presence of senescent cells, which overexpress ß-galactosidase enzyme, the hydrolysis of the galactooligosaccharide capping molecules take place and the cargo release from the inner of the pores is produced (rhodamine B). After the in vitro studies, the ability of nanoparticles to accumulate and release their payload in tissues with abundance of senescent cells was evaluated in vivo. For that purpose, mice with induced pulmonary fibrosis, pathogenesis with associated increased alveolar senescence, were treated with the synthesized material and subsequently examined to assess its ability to accumulate and release its payload (fluorophore) in lung's damaged areas. In the fifth chapter of the thesis it has been explored the concept of cascade chemical communication using different types of nanodevices, each of them loaded with a certain messenger and externally functionalized with a gate-like entity that controls the release of the payload. When the enzyme able to hydrolyze the molecular gate that blocks the pores of the first type of nanoparticles (S1), is added to an aqueous suspension containing the three nanoparticles, the delivery of the chemical messenger 1 is produced. This messenger is able to open the second type of nanoparticles (S2) which delivers the messenger 2. Finally, the messenger 2 triggers the aperture of the third group of gated system (S3), which ultimately delivers its load (a dye) as a final response.
[ES] La presente tesis doctoral titulada "Diseño de nuevos nanodispositivos para procesos avanzados de comunicación y liberación controlada y dirigida de agentes terapéuticos" está centrada en el desarrollo de nuevos materiales híbridos orgánico-inorgánicos funcionales para aplicaciones en el campo de la liberación controlada de moléculas de interés. El primer capítulo de la tesis ofrece una introducción a los materiales híbridos orgánico-inorgánicos funcionalizados con "puertas moleculares" y su aplicación en procesos de liberación controlada. En el segundo capítulo de la tesis se aborda el desarrollo de un nanodispositivo capaz de responder y liberar su carga en función de la concentración de glucosa. Este nanodispositivo está basado en nanoparticulas de sílice mesoporosa funcionalizadas en su superficie externa con grupos benzimidazol y con los poros cargados con un fluoróforo. Los poros se cierran al añadir la enzima glucosa oxidasa funcionalizada con ciclodextrinas (por formación de un complejo de inclusión entre el benzimidazol y los oligosacáridos cíclicos). Al adicionar glucosa se produce su oxidación enzimática dando ácido glucónico. Este ácido induce una bajada del pH del medio con la consiguiente protonación de los benzimidazoles y la ruptura de los complejos de inclusión. Esta ruptura provoca la salida de la enzima de la superficie y la liberación del colorante atrapado en los poros. El tercer capítulo de la tesis se ha centrado en el desarrollo de un material para la liberación controlada de agentes citotóxicos en células cancerosas en respuesta a cambios en el potencial redox. De nuevo se emplean nanopartículas de sílice mesoporosa con los poros cargados con un colorante (safranina O) y la superficie externa funcionalizada con dos polietilenglicoles conteniendo enlaces disulfuro. En presencia de glutatión se produce la reducción del enlace disulfuro con la consiguiente liberación del colorante. Una vez confirmado el protocolo de apertura, se estudió la internalización y la liberación de un fluoróforo y de un agente citotóxico en el modelo celular HeLa, realizando además ensayos de viabilidad. En el cuarto capítulo de la tesis se ha preparado y ensayado un nanodispositivo para la liberación controlada en células senescentes en un modelo murino de fibrosis pulmonar. El material se prepara empleando nanopartículas de sílice mesoporosa y un galactooligosacárido anclado en la superficie externa. En presencia de células senescentes, que sobreexpresan la enzima ¿-galactosidasa, se produce la hidrólisis del oligosacárido con la consiguiente liberación de la carga atrapada en los poros del soporte (rodamina B). Tras los estudios in vitro, la capacidad del nanodispositivo de acumularse y liberar su carga en tejidos ricos en células senescentes se evaluó in vivo. Para ello, ratones con fibrosis pulmonar inducida, patología en la que se ha descrito la aparición de senescencia, se trataron con el material sintetizado y posteriormente fueron examinados para comprobar la capacidad de acumularse y liberar su carga (fluoróforo) en la zona pulmonar dañada. En el quinto capítulo se ha explorado el proceso de comunicación química en cascada empleando tres tipos de nanopartículas mesoporosas de sílice cargadas con diferentes mensajeros y funcionalizadas con tres puertas moleculares distintas. Cuando sobre una suspensión de las tres nanopartículas se añade la enzima capaz de hidrolizar la puerta molecular que bloquea los poros del primer tipo de nanopartículas (S1), se produce la liberación del mensajero 1. Este mensajero es capaz de inducir la apertura del segundo tipo de nanopartículas (S2), que a su vez liberan al medio el mensajero 2. Por último, el mensajero 2 es capaz de abrir la puerta molecular del tercer tipo de nanopartículas (S3), que liberan finalmente su carga (un colorante) como respuesta final.
[CAT] La present tesis doctoral titulada "Disseny de nous nanodispositius per a processos avançats de comunicació i lliberació controlada i dirigida d'agents terapèutics" està centrada en el desenvolupament de nous materials híbrids orgànic-inorgànic funcionals per a aplicacions en el camp de la lliberació controlada de molècules d'interès. El primer capítol de la tesis ofereix una introducció als materials híbrids orgànic-inorgànic funcionalitzats amb "portes moleculars" i la seua aplicació en processos de lliberació controlada. En el segon capítol de la tesis s'aborda el desenvolupament d'un nanodispositiu capaç de respondre i lliberar la seua càrrega en funció de la concentració de glucosa. Este nanodispositiu està basat en nanopartícules de sílice mesoporoses funcionalitzades a la seua superfície externa amb grups benzimidazol i amb els pors carregats amb un fluoròfor. Els pors queden bloquejats al afegir el enzim glucosa oxidasa funcionalitzada amb ciclodextrines (per formació d'un complex d'inclusió entre el benzimidazol i els oligosacàrids cíclics). Al afegir glucosa es produeix la seua oxidació enzimàtica donant lloc a àcid glucònic. Este àcid indueix una baixada del pH del medi amb la consegüent protonació dels benzimidazols i el trencament dels complexes d'inclusió. Este trencament provoca l'eixida del enzim de la superfície i la lliberació del colorant atrapat als pors. El tercer capítol de la tesis s'ha centrat en la preparació d'un material per a la lliberació controlada d'agents citotòxics en cèl¿lules canceroses en resposta a canvis en el potencia redox. De nou s'empren nanopartícules de sílice mesoporoses amb els pors carregats amb un colorant (safranina O) i la superfície externa funcionalitzada amb dos polietilenglicols (de diferent pes molecular) contenint enllaços disulfur. En presència de glutatió es produeix la reducció del enllaç disulfur amb la consegüent lliberació del colorant. Una volta confirmat el protocol d'obertura, es va estudiar la internalització i la lliberació d'un fluoròfor i d'un agent citotòxic en el model cel¿lular HeLa, realitzant ademés assajos de viabilitat. En el quart capítol de la tesis s'ha preparat i s'ha estudiat un nanodispositiu per a la lliberació controlada en cèl¿lules senescents, en un model murí de fibrosis pulmonar. El material es prepara emprant nanopartícules de sílice mesoporoses i un galactooligosacàrid anclat a la superfície externa del material. En presència de cèl¿lules senescents, que sobreexpresen el enzim ¿-galactosidasa, es produeix la hidròlisis del oligosacàrid amb el consegüent alliberament de la càrrega atrapada en els pors del suport (rodamina B). Després dels estudis in vitro, la capacitat del nanodispositiu d'acumular-se i lliberar la càrrega en teixits rics en cèl¿lules senecents es va evaluar in vivo. Amb este propòsit, ratolins amb fibrosis pulmonar induïda, patologia en la que s'ha descrit l'aparició de senescència en els teixits danyats, es van tractar amb el material sintetitzat i posteriorment van ser examinats per a comprovar la capacitat d'acumular-se i lliberar la seua càrrega (fluoròfor) en la zona dels pulmons afectada. En el quint capítol s'ha explorat el procés de comunicació química en cascada utilitzant tres tipus de nanopartícules mesoporoses de sílice carregades amb diferents missatgers i funcionalitzades amb tres portes moleculars diferents. Quan, sobre una suspensió de les tres nanopartícules, s'afegeix l'enzim capaç d'hidrolitzar la porta molecular que bloqueja els pors del primer tipus de nanopartícules (S1), es produeix la lliberació del missatger 1 des de S1. Este missatger és capaç d'induir l'obertura del segon tipus de nanopartícules (S2), les quals lliberen al medi el missatger 2. Per últim, el missatger 2 és capaç d'obrir la porta molecular del tercer tipus de nanopartícules (S3), que lliberen finalment la seua càrr
Giménez Morales, C. (2016). Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/62822
TESIS
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Geh, Katharina Jasmin [Verfasser]. "Gelatine Nanoparticles as Immunomodulatory Drug Delivery System - Advanced Production Processes and Clinical Trials / Katharina Jasmin Geh." München : Verlag Dr. Hut, 2018. http://d-nb.info/1170474063/34.

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Geh, Katharina [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "Gelatine nanoparticles as immunomodulatory drug delivery system : advanced production processes and clinical trials / Katharina Geh ; Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1156851882/34.

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Moura, Lucas Alves 1981. "Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290385.

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Abstract:
Orientador: Antonio Wilson Sallum
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-26T23:52:25Z (GMT). No. of bitstreams: 1 Moura_LucasAlves_D.pdf: 4231687 bytes, checksum: ec30a84348074c7f0f52d37535f57bbe (MD5) Previous issue date: 2015
Resumo: O objetivo deste estudo foi avaliar o efeito da associação da administração local de nanoesferas contendo doxiciclina (DOX) com o debridamento periodontal no tratamento da periodontite crônica avançada. As nanoesferas foram preparadas pelo método da dupla emulsão (W/O/W), e caracterizadas quanto à morfologia através da microscopia eletrônica de varredura (MEV), e quanto à interação polímero (PLGA) e DOX através da espectroscopia infravermelha da transformada de Fourier (FTIR). A avaliação da liberação controlada de DOX foi feita através da cromatografia líquida de alta eficiência (HPLC), a partir do fluido gengival sulcular (GCF) coletado nos períodos: 2, 5, 7, 10, 15 e 20 dias após aplicação das nanoesferas. Foi realizado um ensaio clínico randomizado controlado duplo cego, incluindo 30 pacientes diagnosticados com periodontite crônica que apresentavam sete sítios com sangramento à sondagem e profundidade de sondagem (PS) ? 5 mm, sendo 2 dentes com PS ? 7 mm. Os pacientes foram aleatoriamente divididos em 2 grupos e receberam os seguintes tratamentos: debridamento periodontal por 45 minutos associado à administração local de nanoesferas contendo doxiciclina nos sítios com PS ? 5 mm (DB+DOX) ou debridamento periodontal por 45 minutos associado à aplicação de nanoesferas vazias (DB). Foram avaliados os seguintes parâmetros clínicos: Índice de Placa (IP), Sangramento à Sondagem (SS), Profundidade de Sondagem (PS) e Nível de Inserção Clínica (NIC), no baseline, 3 e 6 meses após a terapia. A avaliação microbiológica foi feita por meio da reação de cadeia de polimerase ¿ tempo real ("real time" - PCR) para detecção das bactérias: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans e Prevotella intermedia, provenientes do biofilme subgengival coletado no baseline, 1, 3 e 6 meses após o tratamento. Os resultados foram comparados por meio do teste de análise de variância com medidas repetidas, com nível de significância de 5%. Foram obtidas nanoesferas variando de 700 nm a 4 um. Através do FTIR observou-se boa interação da DOX com o PLGA, sem alterações das propriedades químicas de nenhum dos compostos. Após a aplicação das nanoesferas observou-se uma liberação de DOX constante no GCF até o vigésimo dia pós-tratamento, acima da concentração inibitória mínima. No grupo DB+DOX houve redução significativa da PS e ganho de inserção clínica nas bolsas profundas e moderadas em relação ao baseline e entre grupos. Observou-se redução significativa dos níveis bacterianos pós-tratamento, sendo o grupo DB+DOX mais eficaz em manter os níveis mais baixos após 6 meses do tratamento. Dentro das limitações deste trabalho, os resultados sugerem que as nanoesferas de PLGA são efetivas como sistema de liberação controlada local de DOX e quando associadas ao debridamento periodontal podem promover resultados superiores em relação à terapia mecânica isoladamente
Abstract: The aim of this study was to assess the effect of the association of local administration of nanospheres loading doxycycline (DOX) with the periodontal debridement treating advanced chronic periodontitis. Nanospheres were made by double-emulsion method (W/O/W) and characterized regarding morphology, by scaning eléctron microscopy (SEM); and drug/polymer interaction, by Fourier transform infrared spectroscopy (FTIR). The DOX controlled release was assessed by high performance liquid chromatography (HPLC) of gingival crevicular fluid (GCF) samples collected 2, 5, 7, 10, 15 and 20 days after treatment. It was performed randomized double-blinded clinical trial, with thirty patients diagnosed with chronic periodontitis presenting at least seven sites with bleeding on probing and probing depth (PD) ? 5 mm, and 2 sites with PD ? 7 mm. The patients were randomly allocated in two groups receiving interventions as followed: 45 minutes periodontal debridement + subgengival nanospheres loading DOX (DB+DOX); and 45 minutes periodontal debridement + subgengival void nanospheres (DB). Plaque index (IP), bleeding on probing (BP), probing depth (PD) and clinical attachment level (CAL) were evaluated on baseline, 3, and 6 months after therapy. Real-time polymerase chain reaction (real-time PCR) was used to quantify Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans and Prevotella intermedia from subgingival biofilm samples collected on baseline, 1, 3 and 6 months after treatment. The results were compared by variance analyses test for repeated measures, with significance of 5%. Nanospheres varying from 700 nm to 4 um were obtained. There was a good interaction between DOX and PLGA, with no chemical properties alterations. After local administration of the nanospheres, it was observed constant DOX release in the GCF until 20th day post-treatment, with concentration above the minimum inhibitory concentration. DB+DOX group showed significant PD reduction and CAL gain in deep and moderates pockets comparing to baseline and between groups. It was observed significant reduction of bacteria levels along follow up period, and DB+DOX group was more eficiente in keeping lower levels of bacteria after 6 months from treatment. Within limitations of this study, the results can suggest that PLGA nanospheres are effective carriers for controlled release of DOX and when used adjunctively to periodontal debridement, improved results can be achieved compared to mechanical therapy alone
Doutorado
Periodontia
Doutor em Clínica Odontológica
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Yapa, Asanka Sajini. "Nanosponges for advanced drug delivery." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35436.

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Doctor of Philosophy
Department of Chemistry
Stefan Bossmann
A novel type of supramolecular aggregate, named "nanosponge" was synthesized through the interaction of novel supramolecular building blocks with trigonal geometry. The cholesterol-(K/D)[subscript n]DEVDGC)₃-trimaleimide unit consists of a trigonal maleimide linker to which homopeptides (either K or D) of variable lengths (n = 5, 10, 15, 20) and a consensus sequence for executioner caspases (DEVDGC) are added via Michael addition. Upon mixing in aqueous buffer, cholesterol-(K)[subscript n]DEVDGC)₃-trimaleimides, as well as a 1:1 mixture of cholesterol-(K/D)[subscript n]DEVDGC)₃-trimaleimides form stable nanosponges, whereas cholesterol-(D)[subscript n]DEVDGC)₃-trimaleimide is unable to form supramolecular aggregates by itself. The structure of the novel nanosponges was revealed through explicit solvent and then coarse-grained molecular dynamics (MD) simulations. The nanosponges are between 80nm and several micrometers in diameters and virtually non-toxic to monocyte/macrophage-like cells. Furthermore, the structure of novel binary nanosponges consisting of cholesterol-(K/D)[subscript n]DEVDGC)₃-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)₂₀ or aspartic acid (D)₂₀ are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges’ structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated. Moreover, the binary (DK20) nanosponges have been found virtually non-toxic in cultures of neural progenitor cells. Additionally, DK20 nanosponges were taken up efficiently by leucocytes (WBC) in peripheral blood within 3h of exposure. The percentage of live cells among the WBC was not significantly decreased by the DK20 nanosponges. Therefore, this novel material holds great promise for improved cell-mediated therapy. Two different nanosponges loaded with the anticancer agent perillyl alcohol (POH) were developed to test the suitability of nanosponges for cell-based cancer therapy. Drug-loaded nanoshuttles featuring trigonal supramolecular building blocks, type (D-POH)₁₀K₂₀ and (D-POH)₁₀R₂₀ were synthesized, purified, and characterized by Dynamic Light Scattering (DLS) and Atomic Force Microscopy (AFM). They were then tested in cell cultures of murine glioma cells (GL26) and murine neural progenitor cells (NPC). The two nanosponges exhibited significantly different biophysical properties (size distribution and zeta potentials). Consequently, different efficacies in killing GL26 and NPC were observed in both, serum free and serum containing culture media. The results from these experiments confirmed that type (D-POH)₁₀K₂₀ nanosponge is an excellent candidate for the cytotherapy of glioblastoma.
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Books on the topic "Advanced drug delivery systems"

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Nayak, Amit Kumar, and Md Saquib Hasnain, eds. Advanced Biopolymeric Systems for Drug Delivery. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8.

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Corbitt, Norma. Advanced drug delivery systems: New developments, new technologies. Norwalk, CT: Business Communications Co., 2001.

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Liu, Zhaosheng, Yanping Huang, and Yi Yang, eds. Molecularly Imprinted Polymers as Advanced Drug Delivery Systems. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0227-6.

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O, Mashkevich Boris, ed. Drug delivery research advances. New York: Nova Science Publishers, 2007.

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Ogata, Naoya, Sung Wan Kim, Jan Feijen, and Teruo Okano, eds. Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2.

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Ogata, Naoya. Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Tokyo: Springer Japan, 1996.

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Coelho, Jorge. Drug delivery systems: Advanced technologies potentially applicable in personalised treatment. Edited by European Association for Predictive, Preventive & Personalized Medicine. Dordrecht: Springer, 2013.

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Oral bioavailability: Basic principles, advanced concepts, and applications. Hoboken, N.J: John Wiley & Sons, 2011.

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Coelho, Jorge, ed. Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6010-3.

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International Symposium on Recent Advances in Drug Delivery Systems (4th 1989 Salt Lake City, Utah). Advances in drug delivery systems, 4: Proceedings of the Fourth International Symposium on Recent Advances in Drug Delivery Systems, SaltLake City, UT, U.S.A., February 21-24, 1989. Amsterdam: Elsevier, 1990.

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Book chapters on the topic "Advanced drug delivery systems"

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Bhatia, Saurabh. "Advanced Application of Natural Polysaccharides." In Systems for Drug Delivery, 147–70. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41926-8_5.

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Nasser Abdelhamid, Hani, and Hui-Fen Wu. "Nanoparticles Advanced Drug Delivery For Cancer Cells." In Nanoparticulate Drug Delivery Systems, 121–50. Toronto ; New Jersey : Apple Academic Press, 2019.: Apple Academic Press, 2019. http://dx.doi.org/10.1201/9781351137263-4.

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Verma, Amit, Ankita Tiwari, Pritish Kumar Panda, Shivani Saraf, Ankit Jain, Sarjana Raikwar, Pooja Bidla, and Sanjay K. Jain. "Liposomes for Advanced Drug Delivery." In Advanced Biopolymeric Systems for Drug Delivery, 317–38. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8_12.

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Prajapati, Shiv Kumar, and Aakanchha Jain. "Dendrimers for Advanced Drug Delivery." In Advanced Biopolymeric Systems for Drug Delivery, 339–60. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8_13.

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Hasnain, Md Saquib, Syed Anees Ahmed, Saad Alkahtani, Milan Milivojevic, Chandi Charan Kandar, Amal Kumar Dhara, and Amit Kumar Nayak. "Biopolymers for Drug Delivery." In Advanced Biopolymeric Systems for Drug Delivery, 1–29. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8_1.

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Cassano, Roberta, and Sonia Trombino. "Drug Delivery Systems: Smart Polymeric Materials." In Advanced Polymers in Medicine, 341–70. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-12478-0_12.

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Shariatinia, Zahra. "Biopolymeric Nanocomposites in Drug Delivery." In Advanced Biopolymeric Systems for Drug Delivery, 233–90. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8_10.

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Kirtania, Moumita Das, Nancy Kahali, and Arindam Maity. "Biopolymeric Gels in Drug Delivery." In Advanced Biopolymeric Systems for Drug Delivery, 57–81. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8_3.

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Penn, R. D. "Advances in Drug Delivery Systems: Neurosurgical Applications." In Advanced Technology in Neurosurgery, 208–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83123-2_22.

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Schlesinger, Erica, Daniel A. Bernards, Rachel Gamson, and Tejal A. Desai. "Nanotemplated Materials for Advanced Drug Delivery Systems." In Molecular Materials, 289–308. Boca Raton, FL : CRC Press, [2017]: CRC Press, 2017. http://dx.doi.org/10.1201/9781315118697-12.

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Conference papers on the topic "Advanced drug delivery systems"

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Chen, Michael. "Nanotechnologies for Advanced Drug Delivery Systems." In The 5th World Congress on New Technologies. Avestia Publishing, 2019. http://dx.doi.org/10.11159/icbb19.02.

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George, Ashline, and Jerin Cyriac. "Nano particle based drug delivery systems." In 2017 Third International Conference on Advances in Electrical, Electronics, Information, Communication and Bio-Informatics (AEEICB). IEEE, 2017. http://dx.doi.org/10.1109/aeeicb.2017.7972386.

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Kulinsky, Lawrence, Han Xu, Han-Kuan A. Tsai, and Marc Madou. "System-based approach for an advanced drug delivery platform." In Smart Structures and Materials, edited by Yuji Matsuzaki. SPIE, 2006. http://dx.doi.org/10.1117/12.658890.

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Usta, Aybala, and Ramazan Asmatulu. "Synthesis and Analysis of Electrically Sensitive Hydrogels for Advanced Drug Delivery Systems." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51120.

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Electrically sensitive polyvinyl alcohol (PVA) hydrogels loaded with methotrexate (MTX) were prepared via a solution casting process, and characterized by attenuated total reflectance (ATR) spectrometry. In order to determine if the hydrogels were electro-sensitive or not, bending tests were conducted on the sulfoacetic acid modified hydrogels. It was observed that the prepared samples into strip forms started bending towards the cathode, and this bending was reversible when the polarity of the applied voltage was changed. The drug release study was performed on the MTX-loaded hydrogel strips placed in a sodium chloride (NaCl) solution under three different voltages (e.g., 0V, 5V, 10V, and 20V). Subsequently, the solutions were collected every five minutes in order to determine the drug release behaviors of the hydrogels using an ultraviolet-visible (UV-Vis) spectrophotometer. The test results showed that sulfoacetic acid (SA)-modified PVA hydrogels possess electrical sensitive behavior and kept their electric sensitivity for a long period of time. Also, the results confirmed that the control drug release could be achieved under different electrical voltages.
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Devi, Meena, and Shachi Awasthi. "Gold nanoparticles in drug delivery systems: Therapeutic applications." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122562.

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El-Garawany, Ahmed H., Mohamed E. Karar, and Mohamed A. El-Brawany. "Embedded drug delivery controller for cancer chemotherapy under treatment constrains." In 2017 Intl Conf on Advanced Control Circuits Systems (ACCS) Systems & 2017 Intl Conf on New Paradigms in Electronics & Information Technology (PEIT). IEEE, 2017. http://dx.doi.org/10.1109/accs-peit.2017.8303050.

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Kumar, Naveen, Syed Hassan, and Jungwon Yoon. "Optimized targeting of magnetic nano particles for drug delivery system." In 2013 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM). IEEE, 2013. http://dx.doi.org/10.1109/aim.2013.6584155.

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Krishnamoorthy, G., P. Stephen, M. Prabhu, P. K. Sehgal, S. Sadulla, P. K. Giri, D. K. Goswami, A. Perumal, and A. Chattopadhyay. "Collagen Coated Nanoliposome as a Targeted and Controlled Drug Delivery System." In INTERNATIONAL CONFERENCE ON ADVANCED NANOMATERIALS AND NANOTECHNOLOGY (ICANN-2009). AIP, 2010. http://dx.doi.org/10.1063/1.3504292.

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Zhou, Hao, Gursel Alici, Weihua Li, and Shaya Ghanbar. "Experimental characterization of a robotic drug delivery system based on magnetic propulsion." In 2011 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM). IEEE, 2011. http://dx.doi.org/10.1109/aim.2011.6027069.

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Marin, Maria-Minodora, Madalina Georgiana Albu Kaya, Mihaela Violeta Ghica, Elena Danila, Gheorghe Coara, Lacramioara Popa, Ciprian Chelaru, et al. "Design and evaluation of doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration." In The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.16.

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Cartilage damage is difficult to self-heal due to an avascular microenvironment and distinct mechanical properties. These features are a challenge in designing a cartilaginous tissue with repairing effect without producing any local infections. Thus, a biodegradable scaffold in which the drug can be incorporated is preferable. Drug delivery systems based on collagen sponges have progressively become remarkable biomaterials for different medical applications. The aim of this work was to design and characterize some collagen/chondroitin sulfate supports with doxycycline for cartilage tissue regeneration. The doxycycline should prevent the development of potential infections. Collagen, chondroitin sulfate and doxycycline gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices. The structural characteristics for the new synthesized biomaterials were firstly assessed by infrared spectroscopy (FT-IR), and scaffolds morphology was then evaluated by optical microscopy and water uptake. The enzymatic biodegradation was also performed. Also, the sponges surface properties were quantified through contact angle. The in vitro doxycycline kinetics release was performed with a dissolution equipment and the release mechanism was investigated. The obtained results recommend these new scaffolds based on doxycycline/collagen/chondroitin sulfate as a promising approach for the treatment of cartilage problems.
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Reports on the topic "Advanced drug delivery systems"

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Popova, Teodora, Borislav Tzankov, Christina Voycheva, Krassimira Yoncheva, and Nikolai Lambov. Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2019. http://dx.doi.org/10.7546/crabs.2019.12.08.

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Zarabi, Bahar, and Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, July 2005. http://dx.doi.org/10.21236/ada439254.

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Zarabi, Bahar, and Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada469974.

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Zarabi, Bahar. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, December 2007. http://dx.doi.org/10.21236/ada480781.

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UNIVERSAL TECHNOLOGY CORP DAYTON OH. Rapid Response Research and Development (R&D) for the Aerospace Systems Directorate. Delivery Order 0004: Research for Propulsion and Power Systems. Volume 2 - Students Exploring Advanced Technologies (SEAT) Program. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada618909.

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Razdan, Rahul. Unsettled Topics Concerning Human and Autonomous Vehicle Interaction. SAE International, December 2020. http://dx.doi.org/10.4271/epr2020025.

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This report examines the current interaction points between humans and autonomous systems, with a particular focus on advanced driver assistance systems (ADAS), the requirements for human-machine interfaces as imposed by human perception, and finally, the progress being made to close the gap. Autonomous technology has the potential to benefit personal transportation, last-mile delivery, logistics, and many other mobility applications enormously. In many of these applications, the mobility infrastructure is a shared resource in which all the players must cooperate. In fact, the driving task has been described as a “tango” where we—as humans—cooperate naturally to enable a robust transportation system. Can autonomous systems participate in this tango? Does that even make sense? And if so, how do we make it happen?
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Lehotay, Steven J., and Aviv Amirav. Ultra-Fast Methods and Instrumentation for the Analysis of Hazardous Chemicals in the Food Supply. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7699852.bard.

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Original proposal objectives: Our main original goal was to develop ultra-fast methods and instrumentation for the analysis of hazardous chemicals in the food supply. We proposed to extend the QuEChERS approach to veterinary drugs and other contaminants, and conduct fast and ultra-fast analyses using novel 5MB-MS instrumentation, ideally with real samples. Background to the topic: The international trade of agricultural food products is a $1.2 trill ion annual market and growing. Food safety is essential to human health, and chemical residue limits are legislated nationally and internationally. Analytical testing for residues is needed to conduct risk assessments and regulatory enforcement actions to ensure food safety and environmental health, among other important needs. Current monitoring methods are better than ever, but they are still too time-consuming, laborious, and expensive to meet the broad food testing needs of consumers, government, and industry. As a result, costs are high and only a tiny fraction of the food is tested for a limited number of contaminants. We need affordable, ultra-fast methods that attain high quality results for a wide range of chemicals. Major conclusions, solutions and achievements: This is the third BARD grant shared between Prof. Amirav and Dr. Lehotay since 2000, and continual analytical improvements have been made in terms of speed, sample throughput, chemical scope, ease-of-use, and quality of results with respect to qualitative (screening and identification) and quantitative factors. The QuEChERS sample preparation approach, which was developed in conjunction with the BARD grant in 2002, has grown to currently become the most common pesticide residue method in the world. BARD funding has been instrumental to help Dr. Lehotay make refinements and expand QuEChERS concepts to additional applications, which has led to the commercialization of QuEChERS products by more than 20 companies worldwide. During the past 3 years, QuEChERS has been applied to multiclass, multiresidue analysis of veterinary drug residues in food animals, and it has been validated and implemented by USDA-FSIS. QuEChERS was also modified and validated for faster, easier, and better analysis of traditional and emerging environmental contaminants in food. Meanwhile, Prof. Amirav has commercialized the GC-MS with 5MB technology and other independent inventions, including the ChromatoProbe with Agilent, Bruker, and FUR Systems. A new method was developed for obtaining truly universal pesticide analysis, based on the use of GC-MS with 5MB. This method and instrument enables faster analysis with lower LaDs for extended range of pesticides and hazardous compounds. A new approach and device of Open Probe Fast GC-MS with 5MB was also developed that enable real time screening of limited number of target pesticides. Implications, both scientific and agricultural: We succeeded in achieving significant improvements in the analysis of hazardous chemicals in the food supply, from easy sample preparation approaches, through sample analysis by advanced new types of GC-MS and LCMS techniques, all the way to improved data analysis by lowering LaD and providing greater confidence in chemical identification. As a result, the combination of the QuEChERS approach, new and superior instrumentation, and the novel monitoring methods that were developed will enable vastly reduced time and cost of analysis, increased analytical scope. and a higher monitoring rate. This provides better enforcement, an added impetus for farmers to use good agricultural practices, improved food safety and security, increased trade. and greater consumer confidence in the food supply.
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