Relevant bibliographies by topics / Advanced bioink

Academic literature on the topic 'Advanced bioink'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Advanced bioink"

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Gu, Yawei, Benjamin Schwarz, Aurelien Forget, Andrea Barbero, Ivan Martin, and V. Prasad Shastri. "Advanced Bioink for 3D Bioprinting of Complex Free-Standing Structures with High Stiffness." Bioengineering 7, no. 4 (November 7, 2020): 141. http://dx.doi.org/10.3390/bioengineering7040141.

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One of the challenges in 3D-bioprinting is the realization of complex, volumetrically defined structures, that are also anatomically accurate and relevant. Towards this end, in this study we report the development and validation of a carboxylated agarose (CA)-based bioink that is amenable to 3D printing of free-standing structures with high stiffness at physiological temperature using microextrusion printing without the need for a fugitive phase or post-processing or support material (FRESH). By blending CA with negligible amounts of native agarose (NA) a bioink formulation (CANA) which is suitable for printing with nozzles of varying internal diameters under ideal pneumatic pressure was developed. The ability of the CANA ink to exhibit reproducible sol-gel transition at physiological temperature of 37 °C was established through rigorous characterization of the thermal behavior, and rheological properties. Using a customized bioprinter equipped with temperature-controlled nozzle and print bed, high-aspect ratio objects possessing anatomically-relevant curvature and architecture have been printed with high print reproducibility and dimension fidelity. Objects printed with CANA bioink were found to be structurally stable over a wide temperature range of 4 °C to 37 °C, and exhibited robust layer-to-layer bonding and integration, with evenly stratified structures, and a porous interior that is conducive to fluid transport. This exceptional layer-to-layer fusion (bonding) afforded by the CANA bioink during the print obviated the need for post-processing to stabilize printed structures. As a result, this novel CANA bioink is capable of yielding large (5–10 mm tall) free-standing objects ranging from simple tall cylinders, hemispheres, bifurcated ‘Y’-shaped and ‘S’-shaped hollow tubes, and cylinders with compartments without the need for support and/or a fugitive phase. Studies with human nasal chondrocytes showed that the CANA bioink is amenable to the incorporation of high density of cells (30 million/mL) without impact on printability. Furthermore, printed cells showed high viability and underwent mitosis which is necessary for promoting remodeling processes. The ability to print complex structures with high cell densities, combined with excellent cell and tissue biocompatibility of CA bodes well for the exploitation of CANA bioinks as a versatile 3D-bioprinting platform for the clinical translation of regenerative paradigms.
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Gao, Qiqi, Byoung-Soo Kim, and Ge Gao. "Advanced Strategies for 3D Bioprinting of Tissue and Organ Analogs Using Alginate Hydrogel Bioinks." Marine Drugs 19, no. 12 (December 15, 2021): 708. http://dx.doi.org/10.3390/md19120708.

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Alginate is a natural polysaccharide that typically originates from various species of algae. Due to its low cost, good biocompatibility, and rapid ionic gelation, the alginate hydrogel has become a good option of bioink source for 3D bioprinting. However, the lack of cell adhesive moieties, erratic biodegradability, and poor printability are the critical limitations of alginate hydrogel bioink. This review discusses the pivotal properties of alginate hydrogel as a bioink for 3D bioprinting technologies. Afterward, a variety of advanced material formulations and biofabrication strategies that have recently been developed to overcome the drawbacks of alginate hydrogel bioink will be focused on. In addition, the applications of these advanced solutions for 3D bioprinting of tissue/organ mimicries such as regenerative implants and in vitro tissue models using alginate-based bioink will be systematically summarized.
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Khati, Vamakshi, Harisha Ramachandraiah, Falguni Pati, Helene A. Svahn, Giulia Gaudenzi, and Aman Russom. "3D Bioprinting of Multi-Material Decellularized Liver Matrix Hydrogel at Physiological Temperatures." Biosensors 12, no. 7 (July 13, 2022): 521. http://dx.doi.org/10.3390/bios12070521.

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Bioprinting is an acclaimed technique that allows the scaling of 3D architectures in an organized pattern but suffers from a scarcity of appropriate bioinks. Decellularized extracellular matrix (dECM) from xenogeneic species has garnered support as a biomaterial to promote tissue-specific regeneration and repair. The prospect of developing dECM-based 3D artificial tissue is impeded by its inherent low mechanical properties. In recent years, 3D bioprinting of dECM-based bioinks modified with additional scaffolds has advanced the development of load-bearing constructs. However, previous attempts using dECM were limited to low-temperature bioprinting, which is not favorable for a longer print duration with cells. Here, we report the development of a multi-material decellularized liver matrix (dLM) bioink reinforced with gelatin and polyethylene glycol to improve rheology, extrudability, and mechanical stability. This shear-thinning bioink facilitated extrusion-based bioprinting at 37 °C with HepG2 cells into a 3D grid structure with a further enhancement for long-term applications by enzymatic crosslinking with mushroom tyrosinase. The heavily crosslinked structure showed a 16-fold increase in viscosity (2.73 Pa s−1) and a 32-fold increase in storage modulus from the non-crosslinked dLM while retaining high cell viability (85–93%) and liver-specific functions. Our results show that the cytocompatible crosslinking of dLM bioink at physiological temperatures has promising applications for extended 3D-printing procedures.
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Salg, Gabriel Alexander, Andreas Blaeser, Jamina Sofie Gerhardus, Thilo Hackert, and Hannes Goetz Kenngott. "Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies." International Journal of Molecular Sciences 23, no. 15 (August 2, 2022): 8589. http://dx.doi.org/10.3390/ijms23158589.

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Among advanced therapy medicinal products, tissue-engineered products have the potential to address the current critical shortage of donor organs and provide future alternative options in organ replacement therapy. The clinically available tissue-engineered products comprise bradytrophic tissue such as skin, cornea, and cartilage. A sufficient macro- and microvascular network to support the viability and function of effector cells has been identified as one of the main challenges in developing bioartificial parenchymal tissue. Three-dimensional bioprinting is an emerging technology that might overcome this challenge by precise spatial bioink deposition for the generation of a predefined architecture. Bioinks are printing substrates that may contain cells, matrix compounds, and signaling molecules within support materials such as hydrogels. Bioinks can provide cues to promote vascularization, including proangiogenic signaling molecules and cocultured cells. Both of these strategies are reported to enhance vascularization. We review pre-, intra-, and postprinting strategies such as bioink composition, bioprinting platforms, and material deposition strategies for building vascularized tissue. In addition, bioconvergence approaches such as computer simulation and artificial intelligence can support current experimental designs. Imaging-derived vascular trees can serve as blueprints. While acknowledging that a lack of structured evidence inhibits further meta-analysis, this review discusses an end-to-end process for the fabrication of vascularized, parenchymal tissue.
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Bednarzig, Vera, Emine Karakaya, Aldo Leal Egaña, Jörg Teßmar, Aldo R. Boccaccini, and Rainer Detsch. "Advanced ADA-GEL bioink for bioprinted artificial cancer models." Bioprinting 23 (August 2021): e00145. http://dx.doi.org/10.1016/j.bprint.2021.e00145.

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Lee, Kangseok, and Chaenyung Cha. "Advanced Polymer-Based Bioink Technology for Printing Soft Biomaterials." Macromolecular Research 28, no. 8 (July 2020): 689–702. http://dx.doi.org/10.1007/s13233-020-8134-9.

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Hu, Chen, Taufiq Ahmad, Malik Salman Haider, Lukas Hahn, Philipp Stahlhut, Jürgen Groll, and Robert Luxenhofer. "A thermogelling organic-inorganic hybrid hydrogel with excellent printability, shape fidelity and cytocompatibility for 3D bioprinting." Biofabrication 14, no. 2 (January 24, 2022): 025005. http://dx.doi.org/10.1088/1758-5090/ac40ee.

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Abstract Alginates are the most commonly used bioink in biofabrication, but their rheological profiles make it very challenging to perform real 3D printing. In this study, an advanced hybrid hydrogel ink was developed, a mixture of thermogelling diblock copolymer, alginate and clay i.e. Laponite XLG. The reversible thermogelling and shear thinning properties of the diblock copolymer in the ink system improves handling and 3D printability significantly. Various three-dimensional constructs, including suspended filaments, were printed successfully with high shape fidelity and excellent stackability. Subsequent ionic crosslinking of alginate fixates the printed scaffolds, while the diblock copolymer is washed out of the structure, acting as a fugitive material/porogen on the (macro)molecular level. Finally, cell-laden printing and culture over 21 d demonstrated good cytocompatibility and feasibility of the novel hybrid hydrogels for 3D bioprinting. We believe that the developed approach could be interesting for a wide range of bioprinting applications including tissue engineering and drug screening, potentially enabling also other biological bioinks such as collagen, hyaluronic acid, decellularized extracellular matrices or cellulose based bioinks.
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Kostenko, Anastassia, Che J. Connon, and Stephen Swioklo. "Storable Cell-Laden Alginate Based Bioinks for 3D Biofabrication." Bioengineering 10, no. 1 (December 23, 2022): 23. http://dx.doi.org/10.3390/bioengineering10010023.

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Over the last decade, progress in three dimensional (3D) bioprinting has advanced considerably. The ability to fabricate complex 3D structures containing live cells for drug discovery and tissue engineering has huge potential. To realise successful clinical translation, biologistics need to be considered. Refinements in the storage and transportation process from sites of manufacture to the clinic will enhance the success of future clinical translation. One of the most important components for successful 3D printing is the ‘bioink’, the cell-laden biomaterial used to create the printed structure. Hydrogels are favoured bioinks used in extrusion-based bioprinting. Alginate, a natural biopolymer, has been widely used due to its biocompatibility, tunable properties, rapid gelation, low cost, and easy modification to direct cell behaviour. Alginate has previously demonstrated the ability to preserve cell viability and function during controlled room temperature (CRT) storage and shipment. The novelty of this research lies in the development of a simple and cost-effective hermetic system whereby alginate-encapsulated cells can be stored at CRT before being reformulated into an extrudable bioink for on-demand 3D bioprinting of cell-laden constructs. To our knowledge the use of the same biomaterial (alginate) for storage and on-demand 3D bio-printing of cells has not been previously investigated. A straightforward four-step process was used where crosslinked alginate containing human adipose-derived stem cells was stored at CRT before degelation and subsequent mixing with a second alginate. The printability of the resulting bioink, using an extrusion-based bioprinter, was found to be dependent upon the concentration of the second alginate, with 4 and 5% (w/v) being optimal. Following storage at 15 °C for one week, alginate-encapsulated human adipose-derived stem cells exhibited a high viable cell recovery of 88 ± 18%. Stored cells subsequently printed within 3D lattice constructs, exhibited excellent post-print viability and even distribution. This represents a simple, adaptable method by which room temperature storage and biofabrication can be integrated for on-demand bioprinting.
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Rocca, Marco, Alessio Fragasso, Wanjun Liu, Marcel A. Heinrich, and Yu Shrike Zhang. "Embedded Multimaterial Extrusion Bioprinting." SLAS TECHNOLOGY: Translating Life Sciences Innovation 23, no. 2 (November 13, 2017): 154–63. http://dx.doi.org/10.1177/2472630317742071.

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Embedded extrusion bioprinting allows for the generation of complex structures that otherwise cannot be achieved with conventional layer-by-layer deposition from the bottom, by overcoming the limits imposed by gravitational force. By taking advantage of a hydrogel bath, serving as a sacrificial printing environment, it is feasible to extrude a bioink in freeform until the entire structure is deposited and crosslinked. The bioprinted structure can be subsequently released from the supporting hydrogel and used for further applications. Combining this advanced three-dimensional (3D) bioprinting technique with a multimaterial extrusion printhead setup enables the fabrication of complex volumetric structures built from multiple bioinks. The work described in this paper focuses on the optimization of the experimental setup and proposes a workflow to automate the bioprinting process, resulting in a fast and efficient conversion of a virtual 3D model into a physical, extruded structure in freeform using the multimaterial embedded bioprinting system. It is anticipated that further development of this technology will likely lead to widespread applications in areas such as tissue engineering, pharmaceutical testing, and organs-on-chips.
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Zhang, Lei, Hai Tang, Zijie Xiahou, Jiahui Zhang, Yunlang She, Kunxi Zhang, Xuefei Hu, Jingbo Yin, and Chang Chen. "Solid multifunctional granular bioink for constructing chondroid basing on stem cell spheroids and chondrocytes." Biofabrication 14, no. 3 (April 13, 2022): 035003. http://dx.doi.org/10.1088/1758-5090/ac63ee.

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Abstract Stem cell spheroids are advanced building blocks to produce chondroid. However, the multi-step operations including spheroids preparation, collection and transfer, the following 3D printing and shaping limit their application in 3D printing. The present study fabricates an ‘ALL-IN-ONE’ bioink based on granular hydrogel to not only produce adipose derived stem cell (ASC) spheroids, but also realize the further combination of chondrocytes and the subsequent 3D printing. Microgels (6–10 μm) grafted with β-cyclodextrin (β-CD) (MGβ-CD) were assembled and crosslinked by in-situ polymerized poly (N-isopropylacrylamide) (PNIPAm) to form bulk granular hydrogel. The host-guest action between β-CD of microgels and PNIPAm endows the hydrogel with stable, shear-thinning and self-healing properties. After creating caves, ASCs aggregate spontaneously to form numerous spheroids with diameter of 100–200 μm inside the hydrogel. The thermosensitive porous granular hydrogel exhibits volume change under different temperature, realizing further adsorbing chondrocytes. Then, the granular hydrogel carrying ASC spheroids and chondrocytes is extruded by 3D printer at room temperature to form a tube, which can shrink at cell culture temperature to enhance the resolution. The subsequent ASC spheroids/chondrocytes co-culture forms cartilage-like tissue at 21 d in vitro, which further matures subcutaneously in vivo, indicating the application potential of the fully synthetic granular hydrogel ink toward organoid culture.
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Dissertations / Theses on the topic "Advanced bioink"

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Rathore, Komal. "Dynamic Modeling of an Advanced Wastewater Treatment Plant." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7354.

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Advanced wastewater treatment plants have complex biological kinetics, time variant influent rates and long processing times. The modeling and operation control of wastewater treatment plant gets complicated due to these characteristics. However, a robust operational system for a wastewater treatment plant is necessary to increase the efficiency of the plant, reduce energy cost and achieve environmental discharge limits. These discharge limits are set by the National Pollutant Discharge Elimination System (NPDES) for municipal and industrial wastewater treatment plants to limit the amount of nutrients being discharged into the aquatic systems. This document summarizes the research to develop a supervisory operational and control system for the Valrico Advanced Wastewater Treatment Plant (AWWTP) in the Hillsborough County, Florida. The Valrico AWWTP uses biological treatment process and has four oxidation ditches with extended aeration where simultaneous nitrification and denitrification (SND) takes place. Each oxidation ditch has its own anaerobic basin where in the absence of oxygen, the growth of microorganisms is controlled and which in return also helps in biological phosphorus removal. The principle objective of this research was to develop a working model for the Valrico AWWTP using BioWin which mimics the current performance of the plant, predicts the future effluent behavior and allows the operators to take control actions based on the effluent results to maintain the discharge permit limits. Influent and experimental data from online and offline sources were used to tune the BioWin model for the Valrico Plant. The validation and optimization of the BioWin model with plant data was done by running a series of simulations and carrying out sensitivity analysis on the model which also allowed the development of operation policies and control strategies. The control strategies were developed for the key variables such as aeration requirements in the oxidation ditch, recycle rates and wastage flow rates. A controller that manipulates the wasting flow rate based on the amount of mixed liquor suspended solids (MLSS) was incorporated in the model. The objective of this controller was to retain about 4500-4600 mg/L of MLSS in the oxidation ditch as it is maintained by the Valrico Plant. The Valrico AWWTP recycles around 80% of their effluent and hence, the split ratios were adjusted accordingly in the model to recycle the desired amount. The effluent concentrations from the BioWin model for the parameters such as Total Nitrogen (TN), Ammonia, Nitrate, Nitrite, Total Kjeldahl Nitrogen (TKN) complied with the discharge limits which is usually less than 2 mg/L for all the parameters.
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Čábelková, Nahorniaková Marcela. "Organická soudobá architektura a bydlení." Doctoral thesis, Vysoké učení technické v Brně. Fakulta architektury, 2012. http://www.nusl.cz/ntk/nusl-233242.

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Organic architecture is often used term especially in connection with the daring and experimental form. The exact definition or division is still missing. The founder of modern organic architecture is to be generally considered as Frank Loyd Wright. He was the man who created organic architecture and also made first definition in the early twentieth century, when formulating new architectural styles. Dissertation deals with insufficiently described problem of organic architecture. The main focus is on contemporary production of residential organic architecture in Central Europe. Especially on the particular realizations in Hungary, Czech Republic, Slovak Republic, Austria, Germany and Poland. Beside detail description of European realizations, the dissertation deals also with foundations of organic architecture in U.S.A. and important realizations here. Modern organic architecture primarily originated in the United States of America. The work presents most important contemporary realizations and architects creating resident living organic architecture in other countries around the world in order to complete the overview. The objective of dissertation was describing newest trends in designing buildings for living. Find position of organic architecture and give reasons for it´s increasing popularity, spread and necessity for new development in architecture according to the new trends. Organic architecture is an alternative way of contemporary residential living. It´s popularity is growing in last years in response to the development of modern technologies and materials, the need to protect our natural resources and also to the increasing negatives of globalization and to denial of local traditions and regional specificities. Aspects of organic forms were divided into three main groups according to their main characteristics: form, harmony and sustainable development. Another objective was find location of contemporary organic residential architecture in Czech Republic and abroad. It is rather spread all over the world than concentrated on certain places. Therefore I selected countries that are richer than the others on the occurrence of organic buildings. The objective was also to address architects, specialists, public and especially university teachers of architecture and students themselves. Communication with them was mainly connected with grant project in 2010. The theme of grant project was contemporary organic architecture in residential living. There were lectures about contemporary organic architecture and exhibition on the theme: Contemporary living organic architecture. The publication of the catalog was published under the title: Contemporary organic houses - Europe. I had the opportunity to visit a number of organic family houses abroad. Specifically houses in Slovakia, Hungary and Germany. Results of survey, which was realized by questions to owners and authors of chosen buildings, are included in dissertation. The mail results of dissertation are - make a detail review of organic architecture in residential living - define trends in contemporary organic architecture and residential living - obtain and process answers from owners and authors of chosen buildings within survey - analysis of organic house ( houses) in city planning and landscape - publication of catalogue focused on organic contemporary European houses - article about contemporary organic architecture and residential living will be published in 2012 on archiweb page
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Rastin, Hadi. "3D Bioprinting of Advanced Bioinks for Tissue Engineering Applications." Thesis, 2021. https://hdl.handle.net/2440/133629.

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Organ transplantation would be the first option for those whose tissues/organs have been extremely injured. However, the growing gap between the number of organ donors and receivers has resulted in the long waiting list for organ transplantation. Regenerative medicine has emerged as a promising approach to tackle the crisis associated with organ shortage by employing the principle of engineering and biology. The regenerative medicine aims to support and accelerate the regeneration of defective tissue/organs through combining cells, scaffolds, and growth factors. Among various biofabrication methods, tremendous attention has been devoted to the recently emerged three-dimensional (3D) bioprinting technology for the fabrication of functional tissue-engineered scaffold loaded with cells due to its ability to assemble complex structures with meticulous control over the entire fabrication process. It is a computer-assisted technology that enables the direct fabrication of complex 3D constructs usually layers upon layers fashion according to a pre-designed structure. The 3D bioprinting concept was borrowed from 3D printing technology that has been primarily exploited in fabrication industries as a rapid prototyping technology. Harnessing the 3D printing technology in the generation of personalized implants, tissue-engineered scaffolds, drug delivery devices, tissue models has opened up a new avenue for the biofabrication methods. For bioprinting application, an ideal bioink should possess a set of desirable properties including biodegradability, biocompatibility, providing mechanical strength and rheological properties, and closely mimicking the native tissue microenvironment. The selection of materials to be used as bioinks remains the main bottleneck in the realization of 3D bioprinting technology. This thesis aims to develop novel bioinks to address the challenges associated with current bioinks by employing polymers and nanomaterials. The specific objectives of this thesis are organized into seven chapters that will be presented in the form of a collection of the published papers which are the results of the research. In addition, a literature review has been provided to establish the background of this research. Overall, the main contributions of this thesis to the 3D bioprinting field are as follows: ➢ Development of a novel bioink composed of methylcellulose/gelatin-methacryloyl (MC/GelMA) hydrogel with high shape integrity and improved biological stability (paper 1). ➢ Extending the usage territory of MXene nanosheets to the 3D bioprinting field owing to its favorable features (paper 2).➢ Addressing the poor electrical conductivity of current bioinks by employing poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) conductive polymer for neural tissue engineering (paper 3). ➢ Development of bioink with potent antibacterial activity toward Gram-positive (S. aureus) and Gram-negative (P. aeruginosa) bacterial, while supporting the cellular functions (paper 4).
Thesis (Ph.D.) -- University of Adelaide, School of Chemical Engineering, 2021
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Costa, João Pedro Bebiano e. Costa. "Advanced engineering strategies for bioprinting of patient-specific cartilage tissues." Doctoral thesis, 2019. http://hdl.handle.net/1822/64604.

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Tese de Doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais
Organ shortage and transplantation needs have led to congestion in healthcare systems resulting in a huge socioeconomic impact. Tissue Engineering has been revolutionizing the engineering of functional tissues, making them great alternatives to achieve a better, faster and effective worldwide patient care. Fibrocartilage is an avascular and aneural tissue characterized by the reduced number of cells and can be found in different tissues, such as intervertebral disc (IVD) and meniscus. These tissues own poor regenerative properties where a massive number of individuals have been affected by their degeneration. The current available treatments have shown poor clinical outcomes and none of them can be consensually designated as the “gold” standard treatment. Tissue engineers have been trying to overcome all the current challenges by developing novel approaches where different biomaterials have been explored to achieve a suitable implant (Chap. I and II). However, the pursuit for the “perfect” biomimetic implant is still a big challenge. Therefore, the combination of high-resolution imaging techniques (magnetic resonance imaging and micro-computed tomography) with 3D printing can be a powerful tool to closely mimic the fibrocartilaginous native tissue. This approach can provide reproducibility of the produced scaffolds and allows the production of patient-specific implants, helping to improve patient recovery time and biofunctionality reestablishment (Chap. III). The concept of patientspecificity is explored in this thesis using natural-based materials, where silk fibroin (SF) plays the central role due to its high processing versatility and remarkable mechanical properties. In the first work, indirect printed patient-specific hierarchical scaffolds were produced combining SF with ionicdoped β-tricalcium phosphates (Chap. V). Furthermore, using a 3D printing extrusion-based technology, an innovative SF-based bioink was developed (Chap. VI). Using the previously developed horseradish peroxidase-mediated crosslinking system, 3D patient-specific memory-shape implants were produced (Chap. VII). As third work, a step forward in terms of mimicking the IVD native tissue was given, where the previously developed SF bioink was combined with elastin (Chap. VIII). Finally, an extrusion-based 3D printing hybrid system comprising a gellan gum/fibrinogen cell-laden bioink and a SF methacrylated bioink was developed to produce cell-laden patient-specific implants (Chap. IX). In summary, the proposed novel 3D printing approaches revealed to be promising alternatives for the production of patient-specific implants for fibrocartilage regeneration.
A escassez de órgãos e a necessidade de transplantação levaram ao congestionamento dos sistemas de saúde, resultando num enorme impacto socioeconómico. Engenharia de Tecidos tem revolucionado a fabricação de tecidos, tornando-se uma ótima alternativa para criar um melhor atendimento ao paciente. Fiibrocartilagem é um tecido avascular e aneural caracterizado pelo reduzido numero de células e pode ser encontrado em diferentes tecidos, como o disco intervertebral (DIV) e o menisco. Estes tecidos possuem fracas propriedades regenerativas, contribuindo para um elevado número de indivíduos afetado pela sua degeneração. Os tratamentos atualmente disponíveis revelam resultados inadequados e nenhum é consensualmente designado como o tratamento padrão. Engenheiros têm tentado superar os desafios encontrados, utilizando diferentes biomateriais para desenvolver novas estratégias para produzir implantes adequados (Cap. I e II). No entanto, a procura por um implante biomimético “perfeito” permanece um grande desafio. A combinação de técnicas de imagem de alta resolução (ressonância magnética e tomografia micro-computadorizada) com a impressão 3D pode ser uma ferramenta poderosa para mimetizar o tecido fibrocartilaginoso. Esta abordagem promove a produção de implantes reprodutiveis e específicos para cada paciente, ajudando a melhorar o tempo de recuperação e o restabelecimento da biofuncionalidade do tecido (Cap. III). O conceito de implantes específicos para cada paciente é explorado nesta tese usando materiais de origem natural, onde a fibroína de seda (SF) desempenha um papel central devido à sua elevada versatilidade de processamento e notáveis propriedades mecânicas. No primeiro trabalho, foram produzidos implantes hierárquicos específicos para cada paciente, impressos indiretamente, combinando SF com fosfatos de β-tricálcio dopados com iões (Cap. V). Para além disso, usando uma tecnologia de impressão 3D, desenvolveu-se uma “bioink” de SF usando um processamento rápido (Cap. VI). Utilizando um sistema de reticulao com base na enzima peroxidase, foram produzidos implantes 3D específicos para cada paciente (Cap. VII). No terceiro trabalho, foi feita uma melhoria em termos de mimetização do DIV cojungando elastina com a “bioink” de SF (Cap. VIII). Finalmente, foi desenvolvido um sistema híbrido de impressão 3D baseado em extrusão usando uma “bioink” de goma gelana/fibrinogénio com células encapsuladas e uma “bioink” de SF metacrilada (Cap. IX). Em resumo, estas novas abordagens de impressão 3D revelaram ser alternativas promissoras para a produção de implantes específicos para cada paciente visando a regeneração de fibrocartilagem.
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Books on the topic "Advanced bioink"

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Ren, Lu Quan, Zhen Dong Dai, and Hao Wang. Advances in Bionic Engineering. Trans Tech Publications, Limited, 2013.

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Ren, Luquan. Advances in Bionic Engineering. Trans Tech Publications, Limited, 2014.

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Advances in Bioinformatics and Computational Biology Lecture Notes in Computer Science Lecture Notes in Bioinfo. Springer, 2012.

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Advances in Computer Vision and Computational Biology: Proceedings from IPCV'20, HIMS'20, BIOCOMP'20, and BIOENG'20. Springer International Publishing AG, 2021.

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Tran, Quoc-Nam, Hamid R. Arabnia, Leonidas Deligiannidis, Fernando G. Tinetti, and Hayaru Shouno. Advances in Computer Vision and Computational Biology: Proceedings from IPCV'20, HIMS'20, BIOCOMP'20, and BIOENG'20. Springer International Publishing AG, 2022.

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Book chapters on the topic "Advanced bioink"

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Nam, Seung Yun, and Sang-Hyug Park. "ECM Based Bioink for Tissue Mimetic 3D Bioprinting." In Advances in Experimental Medicine and Biology, 335–53. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0445-3_20.

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Chen, Quansheng, Hao Lin, and Jiewen Zhao. "Bionic Sensors Technologies in Food." In Advanced Nondestructive Detection Technologies in Food, 59–90. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-3360-7_3.

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Vurat, Murat Taner, Can Ergun, Ayşe Eser Elçin, and Yaşar Murat Elçin. "3D Bioprinting of Tissue Models with Customized Bioinks." In Advances in Experimental Medicine and Biology, 67–84. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3258-0_5.

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Moss, Joel, and M. Daniel Lane. "The Biotin-Dependent Enzymes." In Advances in Enzymology - and Related Areas of Molecular Biology, 321–442. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122808.ch7.

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Gupta, Shweta, and Adesh Kumar. "Bionic Functionality of Prosthetic Hand." In Advances in Intelligent Systems and Computing, 1177–90. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-5903-2_123.

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Ge, Huilin, Kai Li, Zhenyang Zhu, and Xuehai Lian. "Design of Turtle Bionic Submersible." In Advances in Intelligent Automation and Soft Computing, 767–72. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81007-8_87.

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González, Eduardo, Yusely Ruiz, and Guang Li. "Novel Bionic Model for Pattern Recognition." In Advances in Cognitive Neurodynamics (II), 537–41. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9695-1_82.

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Shen, Jiaqi, Kaiwei Lian, and Qiuling Yang. "Research on Underwater Bionic Covert Communication." In Advances in Intelligent Systems and Computing, 223–28. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-62746-1_33.

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Zhou, Zude, Shane Xie, and Dejun Chen. "Science of Bionic Manufacturing in Digital Manufacturing Science." In Springer Series in Advanced Manufacturing, 211–45. London: Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-564-4_6.

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Kim, Soon Hee, Do Yeon Kim, Tae Hyeon Lim, and Chan Hum Park. "Silk Fibroin Bioinks for Digital Light Processing (DLP) 3D Bioprinting." In Advances in Experimental Medicine and Biology, 53–66. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3258-0_4.

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Conference papers on the topic "Advanced bioink"

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Radvanyi, Mihaly, Balazs Varga, and Kristof Karacs. "Advanced crosswalk detection for the Bionic Eyeglass." In 2010 12th International Workshop on Cellular Nanoscale Networks and their Applications (CNNA 2010). IEEE, 2010. http://dx.doi.org/10.1109/cnna.2010.5430281.

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Zhang, Daibing, K. H. Low, Haibin Xie, and Lincheng Shen. "Advances and Trends of Bionic Underwater Propulsors." In 2009 WRI Global Congress on Intelligent Systems. IEEE, 2009. http://dx.doi.org/10.1109/gcis.2009.458.

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Quaratesi, Ilaria, Filip Ion-Angi, Cristina Carșote, Sebastian-Bogdan Tutunaru, Mihaela-Doina Niculescu, and Elena Badea. "Synthesis and Characterization of Alginate-Gelatin Hydrogels with Potential Use in Biomedical Field." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.ii.21.

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This work concerns with obtaining and characterization of new hydrogels based on sodium alginate and gelatin in the form of cross-linked polymer networks, aimed at medical applications, for example controlled release of bioactive agents (pharmaceutical industry) and bioinks (regenerative medicine). Our synthesis strategy was based on the use of mild, ecological reaction conditions in the absence of crosslinking agents and organic oxidants. Only industrially available sodium alginate and gelatin from leather wastes, produced at micro-pilot level at INCDTP-ICPI, were used, without the presence of any additional crosslinking agents, to test their ability to form strong 3D gels. Tunable physical-chemical and mechanical properties of the hydrogels have were obtained by varying the ratio sodium alginate: gelatin. Newly synthesized hydrogels were characterized by both analytical methods, such as ATR-FTIR, TG-DTG and SEM, and standard tests for mechanical resistance.
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Koeppe, Ralf, and Gerd Hirzinger. "From Human Arms to a New Generation of Manipulators: Control and Design Principles." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/dsc-24636.

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Abstract With the knowledge of the biological design of the human arm, we lay out the mechatronic design of a new generation of advanced light-weight robot manipulators with human-like dynamic characteristics. To achieve this property, the manipulator does not have to revert to a human-like, bionic design. A serial link manipulator, control technology, and sensorized joint actuators can generate a kinesthesis enabling high fidelity interaction of the robot with its environment. The design and control of the DLR light-weight robot is based on these principles. Based on generic properties governing the dynamic behavior of any arm, we discuss the difference between the human and the advanced robot arm. The mechatronic design of the advanced robot has to make use of these properties in a very different way than its biological counterpart to achieve a similar dynamic behavior.
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Wu, Dazhong, Changxue Xu, and Srikumar Krishnamoorthy. "Predictive Modeling of Droplet Velocity and Size in Inkjet-Based Bioprinting." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6513.

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Additive manufacturing is driving major innovations in many areas such as biomedical engineering. Recent advances have enabled 3D printing of biocompatible materials and cells into complex 3D functional living tissues and organs using bioink. Inkjet-based bioprinting fabricates the tissue and organ constructs by ejecting droplets onto a substrate. Compared with microextrusion-based and laser-assisted bioprinting, it is very difficult to predict and control the droplet formation process (e.g., droplet velocity and size). To address this issue, this paper presents a new data-driven approach to predict droplet velocity and size in the inkjet-based bioprinting process. An imaging system was used to monitor the droplet formation process. To investigate the effects of excitation voltage, dwell time, and rise time on droplet velocity and droplet size, a full factorial design of experiments was conducted. Two predictive models were developed to predict droplet velocity and droplet size using random forests. The accuracy of the two predictive models was evaluated using the relative error. Experimental results have shown that the predictive models are capable of predicting droplet velocity and size with sufficient accuracy.
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Cheng, Lei, Hongyu Chen, Qiuyue Yu, Meng Wu, Qin Liu, and Xin Wang. "Research on bionic olfactory temperature compensation mechanism." In 2017 2nd International Conference on Advanced Robotics and Mechatronics (ICARM). IEEE, 2017. http://dx.doi.org/10.1109/icarm.2017.8273181.

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Wu, Qiuxuan, Zhijun Zhou, and Ke Yang. "Research on bipedal locomotion of bionic octopus." In 2018 3rd International Conference on Advanced Robotics and Mechatronics (ICARM). IEEE, 2018. http://dx.doi.org/10.1109/icarm.2018.8610736.

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Liu, Dexin, Mingming Sun, and Dianwei Qian. "Structural Design and Gait Simulation of Bionic Quadruped Robot." In 2018 International Conference on Advanced Mechatronic Systems (ICAMechS). IEEE, 2018. http://dx.doi.org/10.1109/icamechs.2018.8507037.

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Mateos, Luis A. "Bionic Sea Urchin Robot with Foldable Telescopic Actuator." In 2020 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM). IEEE, 2020. http://dx.doi.org/10.1109/aim43001.2020.9158806.

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Yu, Qiuyue, Lei Cheng, Xin Wang, Yang Chen, and Huaiyu Wu. "Research on bionic rotorcraft robot based olfactory detection." In 2017 2nd International Conference on Advanced Robotics and Mechatronics (ICARM). IEEE, 2017. http://dx.doi.org/10.1109/icarm.2017.8273176.

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