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Dissertations / Theses on the topic 'Adrenergic and thyroid signalling'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Olsen, Jessica M. "β-Adrenergic Signalling Through mTOR". Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142169.

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Adrenergic signalling is part of the sympathetic nervous system and is activated upon stimulation by the catecholamines epinephrine and norepinephrine. This regulates heart rate, energy mobilization, digestion and helps to divert blood flow to important organs. Insulin is released to regulate metabolism of carbohydrates, fats and proteins, mainly by taking up glucose from the blood. The insulin and the catecholamine hormone systems are normally working as opposing metabolic regulators and are therefore thought to antagonize each other. One of the major regulators involved in insulin signalling

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2

Öberg, Anette I. "β-adrenergic signalling and novel effects in skeletal muscle". Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87205.

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Skeletal muscles have, due to their large mass, a big impact on the whole body metabolism. There are many signals that can regulate the functions of skeletal muscles and one such signal is activation of α- and β-adrenoceptors (α- and β-ARs) by epinephrine and norepinephrine. This activation leads to several effects which are examined in this thesis. Stimulation of β-AR on muscle cells induces glucose uptake, an event that both provides the muscle with energy and lowers the blood glucose levels. We discovered two key components in the β-ARs signal to glucose uptake: the transporter protein GL

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3

Glass, Rainer. "Purinergic signalling in endocrine organs : testis, thyroid, thymus." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250178.

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4

El, Mansori Ibtessam Mustafa. "Thyrotropin receptor signalling links skin and thyroid disease." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/46110/.

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Thyroid dysfunction is frequently associated with skin and hair diseases; however, the underlying pathogenic mechanisms are poorly understood. Pathological activation of the thyroid stimulating hormone receptor (TSHR) is the key feature of both hyper- and hypo-thyrodism. Expression of the (TSHR) has been reported in several extra-thyroidal locations including adipose tissue, bone and skin fibroblasts. TSHR expression may explain the association between the thyroid and skin disease. The TSHR can also be activated by a newly discovered glycoprotein hormone, known as thyrostimulin. This hormone i

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5

Balthasar, Sonja. "Sphingolipid signalling in normal and malignant thyroid cells /." Turku : Painosalama Oy, 2007. http://catalogue.bnf.fr/ark:/12148/cb41077764x.

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6

Schramm, Moritz Walter Joachim. "Adrenergic signalling in the central nervous system modulates the reconsolidation of alcohol memories." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648515.

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7

Barnard, Joanna Catherine. "The effect of thyroid hormones on fibroblast growth factor signalling in bone." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419226.

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8

Mitchell, Fiona Elizabeth. "Thyroid hormone signalling and action : the role of iodothyronine transporters and metabolites." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510634.

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9

Baragli, Alessandra. "Assembly and function of multimeric adenylyl cyclase signalling complexes." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111888.

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G protein coupled receptors, G proteins and their downstream effectors adenylyl cyclase (ACs) were thought to transiently interact at the plasma membrane by random collisions following agonist stimulation. However a growing number of studies have suggested that a major revision of this paradigm was necessary to account for signal transduction specificity and efficiency. The revised model suggests that signalling proteins are pre-assembled as stable macromolecular complexes together with modulators of their activity prior to receptor activation. How and where these signalling complexes form and

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10

McCormick, Wanda Denise. "Characterisation of calcium-sensing receptor signalling and feedback regulation in endogenous expression systems." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493946.

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11

Shen, Weijian. "Development of a biophysically detailed mathematical model of a mouse atrial cell for the study of cellular proarrhythmic mechanisms." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/development-of-a-biophysically-detailed-mathematical-model-of-a-mouse-atrial-cell-for-the-study-of-cellular-proarrhythmic-mechanisms(6d03f0a2-7c2e-4cb6-a8e7-39791cbe0136).html.

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Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with abnormal intracellular Ca2+ handling. Understanding AF requires comprehensive understanding of ionic currents, Ca2+ handling, phosphorylation regulation and related signalling pathways, but appropriate models are limited. The aim of this thesis is to develop an ionic model of the mouse atrial myocyte to investigate the cellular proarrhythmic mechanisms. We have developed the first mouse atrial myocyte model that incorporates mathematically detailed ion channels, cellular Ca2+ and Na+ handling and their regulatio

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12

Alsalhin, Aisha Khlani Hassan. "The role of the beta3-adrenergic receptor (β3-AR) in cardioprotection". Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97812.

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Thesis (MScMedSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: It is well-established that transient activation of the β-adrenergic signalling pathway with ligands such as isoproterenol, formoterol and dobutamine, elicits cardioprotection against subsequent long periods of ischaemia. Initially the focus was on the β1- and β2-adrenergic receptors (β1-AR, β2-AR), but recently the β3-AR also emerged as a potential target in the treatment of heart disease. In heart failure, β1- and β2-AR are typically known to be down-regulated while β3-ARs, on the other hand, are up-regulated (Moniotte et

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13

Khoza, Kenneth. "Characterisation of the α2A-adrenoceptor antagonism by mirtazapine and its modifying effects on receptor signalling / Kenneth Khoza". Thesis, North-West University, 2004. http://hdl.handle.net/10394/673.

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Mirtazapine is an atypical antidepressant employed clinically for the treatment of major depression. As a multipotent antagonist it acts at α2a-adrenergic receptors (α2a -ARs). serotonin type-2A receptors (5-HT2a-Rs) and histamine type-I receptors (H1-Rs). Its actions at the α2a-AR have been proposed to play a role in its putative earlier onset of action. However, it is not known whether mirtazapine is a neutral antagonist or inverse agonist at α2a- ARs. The current study aimed to determine the mode of α2a-AR antagonism by mirtazapine, as well as to investigate in vitro the modulatory effects

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14

Bowers, James. "Links between energy homesostasis, thyroid signalling and aging : lessons learnt from WSB/EiJ mice." Paris, Muséum national d'histoire naturelle, 2014. http://www.theses.fr/2014MNHN0002.

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Les hormones thyroïdiennes (HT) contrôlent l’homéostasie énergétique, les taux élevés impactant négativement sur le vieillissement. Notre étude compare des souris contrôles (C57BL/6J) avec la lignée WSB/EiJ (WSB) ayant une longévité exceptionnelle, un taux d’HT faible et une résistance à l’obésité. Nous avons analysé l’effet d’un régime gras sur plusieurs mesures physiologiques (poids, HT, glycémie, insulinémie, calorimétrie indirecte), révélant une grande plasticité métabolique des WSB. Les fonctions mitochondriales ont été suivies comme indicateur des réponses cellulaires. Pour étudier les l

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15

Norman, Ruth Anne Astley. "Remodelling of the cardiac caveolar domain in heart failure and its putative influence on beta adrenergic signalling." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16973/.

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Over 500,000 people in the UK have heart failure (HF). After an initial insult to the heart, sympathetic drive increases which leads to detrimental remodelling of cardiac β-adrenergic receptors (βAR) and further cardiac dysfunction. The main βAR expressed in the heart are the β1AR and β2AR. In heart failure, remodelling is characterised by reduced β1AR density, desensitisation of the remaining β1AR and aberrations of normal βAR signal compartmentalisation. Caveolae, flask-shaped lipid rafts, are present in most cells including cardiac myocytes and are characterised by the presence of caveolin

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16

Hutchinson, Dana Sabine 1976. "Pharmacological characterisation and signalling pathways of recombinant and endogenously expressed mouse β₃-adrenoceptors". Monash University, Dept. of Pharmacology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8516.

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17

Kalofutis, Christos. "The impact of diabetes on cardiac remodelling after myocardial infarction : potential role of thyroid hormone signalling." Thesis, University of Central Lancashire, 2012. http://clok.uclan.ac.uk/6655/.

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Diabetes (DM) increases mortality after myocardial infarction and deteriorates post-ischaemic cardiac remodelling. This study investigated possible implications of thyroid hormone (TH) signalling in either reducing or preventing this response. TH signalling has a regulatory role in metabolism, cardiac function, growth and ischaemic stress. Acute myocardial infarction (AMI) was induced in age–match healthy control rats (AMI-C) and in streptozotocin (STZ)-induced type I diabetic (DM) animals (DM+AMI) using 35 mg/kg body weight while sham operated animals served as controls (SHAM). The results sh

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18

Näsman, Johnny. "Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk." Doctoral thesis, Uppsala University, Department of Physiology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1569.

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<p>The alpha-2 adrenergic receptor (α<sub>2</sub>-AR) subfamily includes three different subtypes, α<sub>2A</sub>-, α<sub>2B</sub>- and α<sub>2C</sub>-AR, all believed to exert their function through heterotrimeric G<sub>i/o</sub>-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α<sub>2</sub>-ARs.</p><p>Evidence is provided for a strong G<sub>s</sub>-protein coupling capability of the α<sub>2B</sub>-AR, leading to stimulation of adenylyl cyclase (AC). The difference between

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19

Näsman, Johnny. "Alpha-2 adrenergic receptors and signal transduction : effector output in relation to G-protein coupling and signalling cross-talk /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5195-0/.

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20

Crumbie, Hayley Elizabeth. "Beta-adrenergic receptor signalling and excitation-contraction coupling in the heart : impact of circadian rhythms and beta-3 receptors." Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/37500.

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A time-of-day variation in myocardial contraction and its response to sympathetic stimulation of β-adrenoceptors (b-ADR) exists, which is reflected by time-of-day variations in intracellular calcium [Ca2+]i regulation and electrical activity. There are three isoforms of β-ADR (β1/β2/β3) and the functional outcome of each receptor differs. β1/β2-ADRs result in positive inotropism, whereas β3-ADR induces a negative inotropic effect, associated with nitric oxide (NO) signalling. The aims of this thesis were to determine the role of the β3-ADR in the time-of-day variation in the response to sympat

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21

Schmohl, Kathrin Alexandra [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Targeting the tumour microenvironment : from thyroid hormone signalling to gene therapy / Kathrin Alexandra Schmohl ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1204005524/34.

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22

Johansson, Catarina. "Physiological changes in mice deficient in different subtypes of thyroid hormone receptors : a focus on studies of heart and muscle /." Stockholm, 1999. http://diss.kib.ki.se/1999/19990429joha/.

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23

Silva, Marcos Vinicius da. "Avaliação da interação do hormônio tiroideano com o sistema nervoso simpático, via receptor α2A adrenérgico, na regulação da maturação e crescimento ósseos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-09112016-100055/.

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Sabe-se que o hormônio tireoideano (HT) regula o desenvolvimento e crescimento dos ossos. No estudo, investigamos se o HT interage com o sistema nervoso simpático (SNS) controlando o crescimento longitudinal ósseo (CLO), e se essa possível interação depende do α2A-AR. Para tanto, avaliamos o efeito de 30 dias de hipotireoidismo (HIPO) e hipertireoidismo (HIPER) e α2A-AR-/- de 21 dias de idade. Vimos que os animais α2A-AR-/- apresentam menor comprimento no fêmur, tíbia, rádio, úmero e L4 quando comparados aos animais Selv. Como esperado, o HIPO e HIPER prejudicaram o CLO desses o

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24

Russo, Giulia. "Novel computational strategies for the identification of new therapeutic targets in melanoma and thyroid cancer." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/4157.

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Cancer signaling pathways have been extensively investigated. However, how cross-talk processes and integrates pathway responses in cancer is still far from being completely elucidated. Genetic and epigenetic alterations lead cells to aberrant proliferation and escapement from physiological mechanism controlling cell growth, survival and migration. In this context, specific mutations transform cellular proto-oncogenes to oncogenes, triggering hyperactivation of signaling pathways, whereas inactivation of tumor suppressors removes critical negative regulators of signaling. MAPK and PI3K/AKT pat

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25

Teixeira, Marilia Bianca Cruz Grecco. "Avaliação do efeito do hormônio tireodiano na estrutura e fisiologia óssea de camundongos com inativação do gene do adrenoceptor α2C." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-07122015-153223/.

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Dados mostram que a estimulação do Sistema Nervoso Simpático (SNS) induz osteopenia via receptor β2-adrenérgico, que é expresso no osso. Porém, um estudo recente demonstrou que camundongos knockouts (KO) para os receptores adrenérgicos α2A e α2C (α2A/α2C-AR-/-) apresentam alta massa óssea, mesmo com hiperatividade simpática. Além disso, esses camundongos são resistentes à osteopenia induzida pelo excesso de hormônio tireoidiano. Esses achados sugerem que o α2A e/ou α2C-AR também possam mediar as ações do SNS no esqueleto e que esses receptores estão env

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Papi, Bianca Neofiti. "Avaliação da interação do hormônio tireoidiano com o sistema nervoso simpático, via receptor Beta2-adrenérgico, na regulação da massa e metabolismo ósseos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-28092018-090735/.

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O hormônio tireoidiano (HT) é essencial para o desenvolvimento, maturação e metabolismo ósseos, enquanto que o sistema nervoso simpático (SNS) é, também, um potente regulador do remodelamento ósseo. Demonstrou-se que SNS regula negativamente a massa óssea, agindo via receptores ?2-adrenérgicos (?2-AR), expressos em osteoblastos. O nosso grupo demonstrou que os receptores ?2 adrenérgicos (?2-AR) também medeiam ações do SNS no esqueleto e que são expressos em osteoblastos, osteócitos, condrócitos e osteoclastos. Considerando-se que o HT interage com o SNS para regular uma série de processos fisi

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27

Martins, Gisele Miyamura. "Avaliação do efeito do hormônio tireoideano na estrutura e fisiologia óssea de camundongos com inativação do Gene do adrenoceptor a2A." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-12062013-083322/.

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Um dos mais importantes achados dos últimos anos foi o de que o remodelamento ósseo está sujeito ao controle do SNC, com o SNS agindo como efetor periférico. Um estudo do nosso grupo demonstrou que camundongos <font face=\"Symbol\">a2A/<font face=\"Symbol\">a2C-AR-/- apresentam um fenótipo de alta massa óssea, como também são resistentes à osteopenia induzida pelo excesso de hormônio HT. Com o intuito de verificar a participação do <font face=\"Symbol\">a2A-AR-/- nestes processos, tivemos como objetivos: caracterizar o fenótipo ósseo de camundongos <font face=\"Symbol\">a2A-AR-/- e avaliar o e

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28

Fonseca, Tatiana de Lourdes. "Interação do sistema nervoso simpático com o hormônio tireoideano na regulação da massa e metabolismo ósseos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-25092009-162113/.

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Sabe-se que a ativação do Sistema Nervoso Simpático (SNS) induz osteopenia via adrenoceptores b2 (b2-AR). Para investigar se o hormônio tireoideano (HT) interage com o SNS para regular a massa óssea, estudamos o efeito do HT em associação com isoproterenol ou propranolol (agonista e antagonista b-adrenérgicos) e avaliamos o efeito do HT em camundongos com elevado tônus simpático, devido à dupla inativação gênica do a2A-AR e a2C-AR (a2A/a2C-AR-/-), autorreceptores que inibem a liberação de noradrenalina. Vimos que esses animais apresentam um fenótipo de alta massa óssea, apesar do elevado tônus

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29

Tibenská, Veronika. "Vliv chladové adaptace na aktivaci adrenergních a tyroidních signálních drah v myokardu potkana." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-446153.

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Despite advances in research and therapy, cardiovascular diseases are still the leading cause of death worldwide. A closer understanding of the endogenous protective mechanism may improve pharmacological interventions for the treatment of heart diseases. Cold acclimation or hardening has strong potential for reducing cardiovascular risk and the literature shows that it stimulates the β-adrenergic and thyroid systems in tissues. At the same time, the adrenergic system in the heart is one of the main regulators of cardiac activity. However, these signaling pathways have surprisingly not been stu

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30

Li, Jiao. "Regulation of cardiac calcium release channels during acute beta-adrenergic stimulation." Thesis, 2013. http://hdl.handle.net/1959.13/1036949.

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Research Doctorate - Doctor of Philosophy (PhD)<br>During β-adrenergic stimulation of the heart, ryanodine receptors (RyRs) Ca²⁺ release channels in the SR can be phosphorylated at residues S2808, S2814 and S2030 causing an increase in RyR activity. The project is to investigate how acute β-adrenergic stimulation of the heart alters regulation of RyRs by intracellular Ca00B²⁺ and Mg²⁺ and the role of these changes in SR Ca²⁺ release and pacemaking. RyRs were isolated from rat hearts, perfused in a Langendorff apparatus for 5 minute and subject to 1 minute perfusion with 1 µM isoproterenol or w

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31

Holland, Patrick. "DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS." Thesis, 2012. http://hdl.handle.net/10222/15245.

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GPCRs are known to form dimeric structures, and this affects their pharmacological properties. The ?2AR and AT1aR are GPCRs that are involved the regulation of the adrenergic and renin-angiotensin systems. The ?2AR is polymorphic at position 164, affecting its responsiveness to adrenergic ligands. Both receptors have been shown to form dimers, but little is known on how dimerization affects their trafficking and signalling following ligand treatments. Plasma membrane localization, arrestin-2 recruitment, and G-protein interactions were determined between receptor dimers using molecular biologi

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32

Huang, Ya-Hui, and 黃雅慧. "Suppression of Thyroid Hormone Receptor Signalling by Orphan Receptor TR4 in Hepatoma Cells." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/37024140913038342487.

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博士<br>長庚大學<br>基礎醫學研究所<br>94<br>Thyroid hormones (T3) regulate growth, development, differentiation, and metabolic processes by interacting with and activating thyroid hormone receptors or associated pathways. Both thyroid hormone receptor (TR) and testicular orphan receptor 4 (TR4) belong to the nuclear hormone receptor superfamily and are ligand-dependent transcription factors. Because of TR4 and TR sharing similar response element configurations, known as a direct repeat with four nucleotide spacings, this study investigated the possibility of cross-talk between the two ligand-dependent sign

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Bi, Yi Jia. "Alterations in cardiac responses to adrenergic agonists and in circulating thyroid hormones in alloxan induced diabetic rats." Thesis, 1994. http://hdl.handle.net/2429/5119.

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The effects of adrenergic agonists in the heart were investigated in isolated cardiac tissues and in the whole heart in 8 week diabetic and age-matched control rats by measuring contractile force following administration of PE in presence of timolol, or ISO. Plasma thyroid hormones as well as insulin, glucose and triglyceride was measured. The contractile force of the isolated cardiac tissues was measured in tissue baths under physiological conditions and results expressed by construction of concentration response curves to adrenoceptors agonists, 10⁻⁹ to 10⁻⁴ M for ISO and 10⁻⁷ to 10⁻³

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RICHARDSON, DOUGLAS. "Subcellular localization and trafficking of the RET receptor tyrosine kinase: implications for signalling and disease." Thesis, 2009. http://hdl.handle.net/1974/7478.

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The RET proto-oncogene encodes a receptor tyrosine kinase (RTK) that is widely expressed in neuroendocrine tissues and is essential for embryonic development of the kidney and enteric nervous system. Mutations leading to constitutive activation of the RET protein underlie various tumours of endocrine tissues. Conversely, loss-of-function mutations of RET lead to Hirschsprung disease, a congenital disorder characterized by a loss of enteric neurons throughout the colon and small intestine. Intracellular trafficking of RTKs through multiple cellular compartments has been shown to impact on d

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Brito, Denise Silva. "Crosstalk between NF-kB and PI3K-Akt-mTOR signalling in thyroid cancer: the pursuit of novel therapeutic options." Master's thesis, 2018. http://hdl.handle.net/10451/36459.

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Tese de mestrado em Biologia Molecular e Genética, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, em 2018<br>As células cancerígenas são o resultado de um processo gradual e complexo chamado oncogénese. Durante este processo, as células normais transformam-se progressivamente em células cancerígenas através da acumulação de diversas alterações genéticas, que eventualmente culminam numa ou mais características definidas como ‘’hallmarks of cancer’’. Estas características foram definidas como propriedades essenciais ao desenvolvimento cancerígeno por Hanahan and Weinberg

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Koide, Emily. "The chilling tail of temperature’s influence on thyroid hormone signalling in the post-embryonic developmental response of Rana catesbeiana cultured tail fin." Thesis, 2021. http://hdl.handle.net/1828/13390.

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Thyroid hormone (TH) is a critical signalling molecule for all vertebrate organisms, playing an especially crucial role in postembryonic development. Given its importance, many studies have focused on further elucidating the initial TH signal response and its method of transduction. Although the primary mechanism of TH response is genomic signalling, alternative mechanisms of early TH signal transduction have been relatively poorly studied. The North American bullfrog, Rana catesbeiana, is a useful model to study these early responses as tadpole post-embryonic development, or metamorphosis, ca

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Abu-Khudir, Rasha. "Molecular determinants of congenital hypothyroidism due to thyroid dysgenesis." Thèse, 2014. http://hdl.handle.net/1866/11176.

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L’hypothyroïdie congénitale par dysgénésie thyroïdienne (HCDT) est la condition endocrinienne néonatale la plus fréquemment rencontrée, avec une incidence d’un cas sur 4000 naissances vivantes. L’HCDT comprend toutes les anomalies du développement de la thyroïde. Parmi ces anomalies, le diagnostic le plus fréquent est l’ectopie thyroïdienne (~ 50% des cas). L’HCDT est fréquemment associée à un déficit sévère en hormones thyroïdiennes (hypothyroïdisme) pouvant conduire à un retard mental sévère si non traitée. Le programme de dépistage néonatal assure un diagnostic et un traitement précoce par

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Stallaert, Wayne. "Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors." Thèse, 2013. http://hdl.handle.net/1866/11055.

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Les récepteurs couplés aux protéines G (RCPGs) représentent la plus grande famille de cibles thérapeutiques pour le traitement d’une panoplie de pathologies humaines. Bien que plusieurs décennies de recherche aient permis de façonner nos connaissances sur ces protéines membranaires, notre compréhension des déterminants moléculaires de leur activité signalétique reste encore limitée. De ces domaines de recherche, une avancée récente a mis à jour un nouveau phénomène, appelé sélectivité fonctionnelle des ligands, qui a bouleversé les paradigmes décrivant leu fonctionnement de ces récepteurs. Ce

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