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Delahunt, Joan Ziegler, and Lisa A. Mische Lawson. "Relationships between adolescent body mass index, physical activity, and sensory-processing patterns." Canadian Journal of Occupational Therapy 84, no. 3 (June 2017): 189–98. http://dx.doi.org/10.1177/0008417417711459.
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Background. Trends show a significant decline with adolescent physical activity (PA). Knowledge regarding how sensory-processing patterns and body mass index (BMI) relate to adolescents’ PA participation is scarce. Purpose. This study investigated if relationships exist between adolescent BMI, sensory processing, and PA participation. Method. This correlational study collected data from 141 adolescents who completed the Adolescent/Adult Sensory Profile and the Physical Activity Questionnaire–Adolescent. Their BMIs were calculated using self-reported age, height, and weight. The data were analyzed using descriptive statistics and two-tailed Spearman’s rank correlation coefficients. Findings. Adolescents with different sensory-processing patterns reported participation in both similar and distinct PAs. Participation in PA and BMI shared no significant correlation. Sensory sensitivity and BMI total ( rs = –.171, p = .044) and BMI percentile ( rs = –.191, p = .024) demonstrated significant correlations. Analysis revealed a correlation between sensory seeking patterns and PA ( rs = .224, p = .008) as well as correlations among sensory quadrants and participation in specific PAs. Implications. Occupational therapists should consider an adolescent’s sensory preferences when recommending PA interventions.
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van den Boogert, Frank, Bram Sizoo, Pascalle Spaan, Sharon Tolstra, Yvonne H. A. Bouman, Witte J. G. Hoogendijk, and Sabine J. Roza. "Sensory Processing and Aggressive Behavior in Adults with Autism Spectrum Disorder." Brain Sciences 11, no. 1 (January 14, 2021): 95. http://dx.doi.org/10.3390/brainsci11010095.
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Autism spectrum disorder (ASD) may be accompanied by aggressive behavior and is associated with sensory processing difficulties. The present study aims to investigate the direct association between sensory processing and aggressive behavior in adults with ASD. A total of 101 Dutch adult participants with ASD, treated in outpatient or inpatient facilities, completed the Adolescent/Adult Sensory Profile (AASP), the Reactive-Proactive Aggression Questionnaire (RPQ), and the Aggression Questionnaire—Short Form (AQ-SF). Results revealed that sensory processing difficulties are associated with more aggressive behavior (f2=0.25), more proactive (f2=0.19) and reactive aggression (f2=0.27), more physical (f2=0.08) and verbal aggression (f2=0.13), and more anger (f2=0.20) and hostility (f2=0.12). Evidence was found for an interaction of the neurological threshold and behavioral response on total aggression and hostility. Participants with higher scores in comparison to the norm group in sensory sensitivity had the highest risk of aggressive behavior. In conclusion, clinical practice may benefit from applying detailed diagnostics on sensory processing difficulties when treating aggressive behavior in adults with ASD.
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Bijlenga, D., J. Y. M. Tjon-Ka-Jie, F. Schuijers, and J. J. S. Kooij. "Atypical sensory profiles as core features of adult ADHD, irrespective of autistic symptoms." European Psychiatry 43 (June 2017): 51–57. http://dx.doi.org/10.1016/j.eurpsy.2017.02.481.
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AbstractBackground:Abnormal sensory sensitivity is a feature of autism-spectrum disorder (ASD), but is also reported in attention-deficit/hyperactivity disorder (ADHD). In many cases, ADHD and ASD are comorbid. This study investigated the prevalence of sensory hyper- and hyposensitivity among adults with ADHD, controlling for autistic symptoms.Method:One hundred and sixteen adults diagnosed with ADHD completed the Adolescent/Adult Sensory Profile-NL (AASP-NL) and the Autism-spectrum Quotient (AQ) questionnaires. Prevalences of hyper- and hyposensitivity and autism-spectrum symptoms were compared to norm values. Multivariate binary logistic regressions were used to determine the association of autistic symptoms, age, gender, ADHD subtype, self-reported severity of ADHD symptoms, comorbid disorders, and use of medication on the sensory hypo- and hypersensitivity in adults with ADHD.Results:Adults with ADHD had more autistic symptoms, and they had both more hyper- and hyposensitivity compared to norm groups. This was especially apparent in the Activity level and Auditory sensory modalities. Sensory hypo- and hypersensitivity were both related to an increased ADHD score, even showing a dose-response relationship, but not to any autistic symptom or comorbid disorder. As much as 43% of the females with ADHD reported sensory hypo- and/or hypersensitivity, compared to 22% of the men.Conclusions:Sensory hypo- and hypersensitivity may be viewed as key features of adult ADHD, especially in females, regardless of any autistic symptoms. Future research should be directed at the implications of this sensory dysregulation for the understanding of the pathophysiology of (female) ADHD, and on the usefulness of assessment of atypical sensory profiles in the diagnostic procedure of ADHD in adults.
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Metz, Alexia E., Daniella Boling, Ashley DeVore, Holly Holladay, Jo Fu Liao, and Karen Vander Vlutch. "Dunn’s Model of Sensory Processing: An Investigation of the Axes of the Four-Quadrant Model in Healthy Adults." Brain Sciences 9, no. 2 (February 7, 2019): 35. http://dx.doi.org/10.3390/brainsci9020035.
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We examined the behavioral response (BR) and threshold (T) axes of Dunn’s four-quadrant model of sensory processing (1997). We assessed whether they are ordinal ranges and if variation is associated with other similarly described characteristics: Introversion/Extraversion (I/E) of Eysenck’s personality model (Sato, 2005), and somatosensory event related potentials (SERP) and their gating (Davies & Gavin, 2007). From healthy adults (n = 139), we obtained: Adult/Adolescent Profile (A/ASP, Brown & Dunn, 2002) and Eysenck’s Personality Questionnaire, Brief Version (Sato, 2005) scores and peak amplitude and gating factor of SERP P50. We found that BR scores did not differ across normative categories of the A/ASP, but T scores significantly increased along the axis. I/E scores did not vary with BR scores. There were no differences or correlations in P50 amplitudes and gating with T scores. The findings suggest that the BR axis may not reflect a construct with ordinal range, but the T axis may. Dunn’s concept of BR appears to be distinct from Eysenck’s concept of I/E. SERP and its gating may not be directly reflective of sensory processing thresholds in healthy adults. Conclusions are limited by having few participants with passive behavior regulation or low threshold patterns of processing.
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Serafini, G., B. Engel-Yeger, G. H. Vazquez, M. Pompili, and M. Amore. "Sensory processing disorders, duration of current episode, and severity of side effects in major affective and anxiety disorders." European Psychiatry 33, S1 (March 2016): s224—s225. http://dx.doi.org/10.1016/j.eurpsy.2016.01.553.
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IntroductionLonger duration of untreated illness, longer duration of current episode, and severity of medication side effects may negatively influence the psychosocial functioning in major affective and anxiety disorders. Studies also suggested the involvement of sensory perception in emotional and psychopathological processes.ObjectiveThe objective of this study is to investigate the nature of the association between duration of untreated illness, duration of current episode, and severity of medication side effects.AimsThe study is aimed to examine the relationship between sensory processing disorders (SPD), duration of untreated illness, duration of current illness episode, and the severity of side effects related to psychoactive medications.MethodsThe sample included 178 participants with an age ranging from 17 to 85 years (mean = 53.84 ± 15.55); psychiatric diagnoses were as follow: unipolar major depressive disorder (MDD) (50%), bipolar disorder (BD) (33.7%), and anxiety disorders (16.3%). subjects completed a socio-demographic questionnaire, the Udvalg for Kliniske Undersøgelser (UKU), and Adolescent/Adult Sensory Profile (AASP) questionnaire.ResultsLonger duration of current episode correlated with greater registration of sensory input and lower avoidance from sensory input among unipolar patients, lower registration of sensory input, and higher tendency for sensory sensitivity/sensation avoidance among bipolar participants. In addition? longer duration of current episode correlated with lower sensory sensitivity/avoidance among anxiety participants, respectively. Mean UKU total scores were associated with lower sensory sensitivity among bipolar individuals as well.ConclusionsSPD expressed in either hypo-/hypersensitivity may be used to clinically characterize subjects with major affective and anxiety disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Rieke, E. F., and D. Anderson. "Adolescent/Adult Sensory Profile and Obsessive-Compulsive Disorder." American Journal of Occupational Therapy 63, no. 2 (March 1, 2009): 138–45. http://dx.doi.org/10.5014/ajot.63.2.138.
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Chang, Megan, Colleen McNeil, Amanda Lord, Jessica Durand, and Emily Langston. "Concurrent Validity of the Adult Sensory Processing Scale and the Adolescent/Adult Sensory Profile." American Journal of Occupational Therapy 70, no. 4_Supplement_1 (August 1, 2016): 7011500059p1. http://dx.doi.org/10.5014/ajot.2016.70s1-po5107.
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Gándara-Gafo, Berta, Sergio Santos-del Riego, and Javier Muñiz. "Reference Values for the Adolescent/Adult Sensory Profile in Spain." American Journal of Occupational Therapy 73, no. 5 (July 17, 2019): 7305205040p1. http://dx.doi.org/10.5014/ajot.2019.028712.
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Gándara-Gafo, Berta, Sergio Santos-del Riego, Inés Viana-Moldes, and Javier Muñiz. "Cultural Adaptation of the Adolescent/Adult Sensory Profile for Spain." American Journal of Occupational Therapy 73, no. 6 (November 1, 2019): 7306205070p1. http://dx.doi.org/10.5014/ajot.2019.031815.
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Üçgül, Merve Şuay, Sevilay Karahan, and Çiğdem Öksüz. "Reliability and validity study of Turkish version of Adolescent/Adult Sensory Profile." British Journal of Occupational Therapy 80, no. 8 (August 2017): 510–16. http://dx.doi.org/10.1177/0308022617706680.
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Kanda, Michelle, Laura Ruzzano, Emily Cohen, and Sharon Cermak. "The Association Between Two Sensory Processing Measures: The Sensory Over-Responsivity Inventory and the Adolescent/Adult Sensory Profile." American Journal of Occupational Therapy 71, no. 4_Supplement_1 (July 1, 2017): 7111500033p1. http://dx.doi.org/10.5014/ajot.2017.71s1-po3035.
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Chung, Sang Mi, and Bo Kyoung Song. "Evaluation of sensory processing abilities following stroke using the adolescent/adult sensory profile: implications for individualized intervention." Journal of Physical Therapy Science 28, no. 10 (2016): 2852–56. http://dx.doi.org/10.1589/jpts.28.2852.
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Almomani, Fidaa, Ahmad Alghadir, Murad Al-Momani, Sami Alharethy, Alham Al-Sharman, Ro'ya Al Dibi'i, and Shahnawaz Anwer. "Performance of the Arabic Population on the Adolescent-Adult Sensory Profile: An Observational Study." Neuropsychiatric Disease and Treatment Volume 16 (January 2020): 35–42. http://dx.doi.org/10.2147/ndt.s232059.
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Jeong, Sang-Mi, and Dae-Sung Han. "A Study on the Construct Validity of Adolescent/Adult Sensory Profile for Stroke Patients." Joural of the Korea Entertainment Industry Association 6, no. 3 (September 30, 2012): 161. http://dx.doi.org/10.21184/jkeia.2012.09.6.3.161.
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Engel-Yeger, Batya. "Validating the Adolescent/Adult Sensory Profile and Examining its Ability to Screen Sensory Processing Difficulties among Israeli People." British Journal of Occupational Therapy 75, no. 7 (July 2012): 321–29. http://dx.doi.org/10.4276/030802212x13418284515839.
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Purpose: The purpose of this study was to (1) validate the Hebrew version of the Adolescent/Adult Sensory Profile (AASP); (2) screen sensory processing difficulties, as expressed in daily living in a vast range of ages of healthy Israeli adolescents, adults and older people; and (3) examine gender effect on sensory processing in the different age groups. Findings: Good internal consistency was found for each of the AASP quadrants, although factor analysis did not find total similarity between the Hebrew version of the AASP and the original AASP. Sensory processing difficulties were shown by 22–42% of the participants in the different age groups. Older participants had lower tendency for Sensation Seeking. Females were more sensitive than males in the age groups of 11–17 years and 18–64 years. Conclusion: In general, the Hebrew version of the AASP was found to be valid and succeeded in profiling sensory processing difficulties along the life span of typical Israeli adolescents and adults. Further studies should apply the Hebrew version of the AASP to screen sensory processing difficulties among individuals with disabilities and elaborate their impact on people's performance/participation in daily activities.
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Almomani, Fidaa, Ahmad Alghadir, Murad Al-Momani, Sami Alharethy, Alham Al-Sharman, Ro'ya Al Dibi'i, and Shahnawaz Anwer. "Performance of the Arabic Population on the Adolescent-Adult Sensory Profile: An Observational Study [Corrigendum]." Neuropsychiatric Disease and Treatment Volume 16 (March 2020): 837–38. http://dx.doi.org/10.2147/ndt.s254119.
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Royston, R., C. Oliver, P. Howlin, A. Dosse, P. Armitage, J. Moss, and J. Waite. "The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes." Journal of Autism and Developmental Disorders 50, no. 3 (December 4, 2019): 893–903. http://dx.doi.org/10.1007/s10803-019-04317-1.
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AbstractPsychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.
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Borges, José Manuel, José Antonio García del Castillo, Juan Carlos Marzo, and Álvaro García del Castillo-López. "Relationship Between Sensory Processing, Resilience, Attitudes and Drug use in Portuguese Adults." Paidéia (Ribeirão Preto) 27, no. 68 (December 2017): 255–62. http://dx.doi.org/10.1590/1982-43272768201702.
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Abstract: Research suggests that the relationship between resilience and substance use is a non-linear and multifactorial psychological process. Surprisingly, sensory processing is rarely mentioned as a variable associated with this phenomenon. In this study, we investigated the relationship between resilience, sensory processing, attitudes and consumption behaviors for alcohol, tobacco and other psychoactive substances. For this, we used four instruments: Adult / Adolescent Sensory Profile; Resilience Scale; Attitudes scales; Tobacco, Alcohol and Other Drug Use Scale. The sample consisted of 340 healthy adult participants, of whom 261 (76.8%) were women and 79 (23.2%) men. As for chronological age, the youngest person was 18 and the oldest was 76 years (M = 39; DP = 11). Sensory processing was associated with the intake behaviors and attitudes. Sensory imbalances appeared to be implicated in decreased resilience.
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Paladugu, Radha Kumari, Pavan Chand Donipudi, Divya Chimata, and Manasa Jasti. "Adolescent pregnancy and its outcomes: a cross-sectional study." International Journal Of Community Medicine And Public Health 5, no. 10 (September 24, 2018): 4408. http://dx.doi.org/10.18203/2394-6040.ijcmph20183984.
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Background: Teenage or adolescent pregnancy is a major public health problem worldwide. Studies show that teenage mothers are more likely to experience pregnancy-related complications and maternal death compared to adult mothers. Hence, this study was conducted to study the socio-demographic profile and the maternal and fetal outcomes associated with teenage pregnancy and compare it with those of mothers aged 20-30 years.Methods: A cross-sectional comparative study was conducted in Government General Hospital, Guntur from April 2016 to October 2016. 50 adolescent mothers aged <19 years and 50 mothers aged 20-30 years were respectively selected as cases and controls. Data on socio-demographic profile, obstetric complications and fetal outcome was collected using a pre-designed, pre-tested, semi-structured questionnaire by face-to-face interview. Data was analysed by entering it in MS Excel worksheet.Results: Mean age was 18.2 years in adolescent mothers and 23.2 years in controls. Mean age at marriage was 17.3 years in adolescent mothers and 19.9 years in adults. Among teenage mothers 48% were Hindus, 72% upper lower socio-economic class, 88% from rural areas, 32% illiterates, 72% housewives and 32% had consanguineous marriages. Prevalence of under-nutrition (36% vs 14%, p<0.05), PROM (20% vs 4%, p<0.05), PPH (20% vs 4%, p<0.05) was significantly higher in adolescent mothers compared to adults. Prevalence of PIH was significantly lower in adolescent mothers compared to adults (8% vs 28%, p<0.05).Conclusions: Complications like maternal under-nutrition, PROM, PPH, preterm delivery and low birth weight babies were higher in teenage mothers compared to adult mothers. PIH was higher in adult mothers compared to adolescent mothers.
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Almomani, Fidaa M., Catana Brown, Sana Abu Dahab, Murad Almomani, and Mohammad Nadar. "Cross cultural adaptation of the adolescent/adult sensory profile: establishing linguistic equivalency and psychometric properties of the Arabic version." Disability and Rehabilitation 36, no. 9 (July 26, 2013): 765–70. http://dx.doi.org/10.3109/09638288.2013.819386.
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Engel-Yeger, Batya, and Sara Rosenblum. "The relationship between sensory-processing patterns and occupational engagement among older persons." Canadian Journal of Occupational Therapy 84, no. 1 (February 2017): 10–21. http://dx.doi.org/10.1177/0008417417690415.
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Background. Meaningful occupational engagement is essential for successful aging. Sensory-processing abilities that are known to deteriorate with age may reduce occupational engagement. However, the relationship between sensory-processing abilities and occupational engagement among older persons in daily life is unknown. Purpose. This study examined the relationship between sensory-processing patterns and occupational engagement among older persons. Method. Participants were 180 people, ages 50 to 73 years, in good health, who lived in their homes. All participants completed the Adolescent/Adult Sensory Profile and the Activity Card Sort. Findings. Better registration of sensory input and greater sensory seeking were related to greater occupational engagement. Implications. Sensory-processing abilities among older persons and their relation to occupational engagement in various life settings should receive attention in research and practice. Occupational therapists should encourage older people to seek sensory input and provide them with rich sensory environments for enhancing meaningful engagement in real life.
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Ravn, Maiken Bay, Tinna Klingberg, and Kirsten Schultz Petersen. "The Adult Sensory Profile™ in Care Homes Targeting People Diagnosed with Dementia: A Qualitative Study from the Care Provider Perspective." Rehabilitation Research and Practice 2018 (August 5, 2018): 1–7. http://dx.doi.org/10.1155/2018/5091643.
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Introduction. The background of this study is the pilot testing of the Adolescent /Adult Sensory Profile (A/ASP) in dementia units at municipal nursing homes. Based on the results from therapists’ A/ASP assessment, recommendations are made according to individual needs and forwarded to the health care providers. This study looks into the health care providers’ perspective on the usability of these recommendations. Aim. The aim of this qualitative study is to explore the health care providers’ perspective on the usability of recommendations derived from the A/ASP during a pilot testing of the profile in dementia units for people living with severe dementia. Methods. Participant observations and informal and formal interviews with health care providers at five municipal dementia units during the pilot testing of the A/ASP. Results. In the health care provider perspective, the A/ASP is a relevant and useful tool to use when behavioural challenges among residents living with dementia occur. However, in their opinion, it requires time, adjustment, and further education if recommendations are to be fully implemented in everyday practice at the dementia units.
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Serafini, G., B. Engel-Yeger, X. Gonda, M. Pompili, Z. Rihmer, and M. Amore. "Sensory hypersensitivity predicts reduced sleeping quality in patients with major affective disorders." European Psychiatry 33, S1 (March 2016): S110. http://dx.doi.org/10.1016/j.eurpsy.2016.01.102.
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IntroductionMajor affective disorders ranging from subthreshold affective temperaments to severe affective diseases and anxiety, are frequently associated with sleep–wake dysregulation. Interestingly, recent studies suggested an active role of Sensory Processing Disorders (SPD) in the emergence of sleep disturbances.ObjectivesThe objective of this study was to investigate the relationship between SPD and sleep quality in subjects with major affective disorders and specific affective temperaments.AimsThis study aimed to examine the sensory profile (expressed in hypersensitivity or hyposensitivity) of patients with major affective disorders and its relative contribution to the prediction of sleep quality while also considering affective temperaments and depression, known as factors that may impact sleep quality.MethodsWe recruited 176 participants (mean age = 47.3) of which 56.8% have unipolar depression and 43.2% bipolar disorder. Reduced sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) whereas affective temperaments were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS).ResultsSensory hypersensitivity, assessed using Adolescent/Adult Sensory Profile (AASP), significantly distinguished between poor and good sleepers. Sleep quality was mainly predicted by the Beck Depression Inventory-II total score and anxious temperament. Yet, sensory hypersensitivity contributed to this prediction mainly in regard to sleep efficiency and related daytime dysfunctions.ConclusionsThe careful assessment of the unique sensory profile and its behavioral/functional influence on patients’ quality of life may help clinicians and health providers in developing targeted treatment interventions.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Clark, Jacqui R. "Prevalence of Extreme Trait Sensory Profiles and Personality Types in Nonspecific Chronic Low Back Pain with Predominant Central Sensitization: Secondary Analysis of an International Observational Study." Pain Physician 3, no. 22;3 (May 11, 2019): E181—E190. http://dx.doi.org/10.36076/ppj/2019.22.e181.
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Background: Individuals with nonspecific chronic low back pain (NSCLBP) and central sensitization (CS) exhibit sensory hypersensitivity that may be related to pre-existing trait characteristics. Sensory profiles and trait anxiety-related characteristics have sensory sensitivity in common with CS. Objectives: The objectives of this study were 1) to observe the prevalence of 4 personality types and extreme scores of 4 trait sensory profiles in people with NSCLBP and predominant CS; and 2) to compare these between 2 subgroups based on high and low self-reported CS symptoms. Study Design: An international cross-sectional observational study was undertaken. Setting: Adults (n = 165; mean age = 45 ± 12 standard deviation) were recruited from physiotherapy clinics across 3 countries and 2 continents. Methods: The inclusion criteria were: NSCLBP, aged 18-64 years, with clinically identified predominant CS pain, without specific pathology. The outcome measures were: Central Sensitization Inventory (CSI), Adolescent/Adult Sensory Profile, State/Trait Anxiety Inventory, and Marlowe Crowne Social Desirability Scale. Descriptive and comparative statistics were used. Results: CSI scores ranged from 19-79 (mean = 50). There was a high prevalence of extreme 1) trait sensory hyper- and, unexpectedly, hyposensitivity profile scores (P < 0.001) and Defensive High Anxious personality type (P < 0.01) in the high-CSI (CSI ≥ 40; 78%) subgroup, and 2) trait sensory hyposensitivity profile scores (P < 0.01) and Repressor personality type (P < 0.01) in the low-CSI subgroup (CSI < 40; 22%). Limitations: Self-report measures only were used; limited demographics. Conclusions: To our knowledge, these results are the first to demonstrate extreme trait sensory profiles and personality types in people with NSCLBP and predominant CS. A subgroup who reports low levels of CS symptoms may have a hyposensitive sensory profile and Repressor personality type. Further study is required to investigate the extent to which these trait characteristics may predict CS symptoms in people with NSCLBP. Key words: Central sensitization, nonspecific chronic low back pain, prevalence of extreme trait characteristics, sensory profiles, trait anxiety-related personality types
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Engel-Yeger, Batya, Sari Hus, and Sara Rosenblum. "Age effects on sensory-processing abilities and their impact on handwriting." Canadian Journal of Occupational Therapy 79, no. 5 (December 2012): 264–74. http://dx.doi.org/10.2182/cjot.2012.79.5.2.
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Background. Sensory-processing abilities are known to deteriorate in the elderly. As a result, daily activities such as handwriting may be impaired. Yet, knowledge about sensory-processing involvement in handwriting characteristics among older persons is limited. Purpose To examine how age influences sensory-processing abilities and the impact on handwriting as a daily performance. Method. The study participants were 118 healthy, independently functioning adults divided into four age groups: 31–45, 46–60, 61–75 and 76+ years. All participants completed the Adolescent/Adult Sensory Profile (AASP). Handwriting process was documented using the Computerized Handwriting Penmanship Evaluation Tool (ComPET). Findings. Age significantly affects sensory processing and handwriting pressure as well as temporal and spatial measures. Both handwriting time and spatial organization of the written product were predicted by sensory seeking. When examining age contribution to the prediction of handwriting by sensory processing, sensory seeking showed a tendency for predicting handwriting pressure (p = .06), while sensory sensitivity significantly predicted handwriting velocity. Implications. Age appears to influence sensory-processing abilities and affect daily performance tasks, such as handwriting, for which sensitivity and seeking for sensations are essential. Awareness of clinicians to sensory-processing deficits among older adults and examining their impact on broader daily activities are essential to improve daily performance and quality of life.
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Pi Davanzo, Macarena, Marcela Larraguibel Quiroz, Rodrigo Rojas-Andrade, and Consuelo Aldunate. "Comparative study of adolescents with and without ADHD." Salud mental 41, no. 6 (December 21, 2018): 287–96. http://dx.doi.org/10.17711/sm.0185-3325.2018.041.
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Introduction. Although an association between attention deficit hyperactivity disorder (ADHD) and personality disorders has been observed in adult population, no descriptions in Chilean adolescents have been reported. Objective. To explore personality profiles in Chilean adolescent patients diagnosed with ADHD. Method. Non-experimental, comparative design, convenience sample with 61 adolescent patients (13-19 years old) diagnosed with ADHD who completed the Millon Adolescent Clinical Inventory (MACI) questionnaire. Results compared parameters for the Chilean adolescent population and patients in the study. Attending psychiatrists completed a medical history file (comorbidities, pharmacological treatment and factors associated with mental health). Multivariate statistics, cluster analyses, and means comparison analyses were performed. This project was approved by the Ethics Committee of the University of Chile. Results. The personality profile of female adolescent patients with ADHD resembles that of the general female population, while the profile of the male patients is similar to that of the patient’s parameter group. Cluster analysis identified two personality sub-profiles: 25% of the subjects belonged to cluster 1, which was characterized by higher scores for different personality traits, expressed concerns, and clinical syndromes, compared with subjects from cluster 2. There were no differences regarding gender, ADHD clinical presentation, use of medication, adverse childhood experiences (ACEs), type of school, grade retention, or, applicable only to the female group, comorbidities in belonging to cluster 1. Only the presence of comorbidity in male subjects was associated with cluster 1 membership. Discussion and conclusion. Adolescent patients diagnosed with ADHD differed significantly in some personality traits when compared to Chilean parameters for the MACI. Of the adolescents studied, 25% have maladaptive personality characteristics.
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Colbeck, Melissa. "Sensory processing, cognitive fatigue, and quality of life in multiple sclerosis." Canadian Journal of Occupational Therapy 85, no. 2 (February 26, 2018): 169–75. http://dx.doi.org/10.1177/0008417417727298.
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Background. Quality of life for persons living with multiple sclerosis (MS) is significantly lower than population norms. Fatigue, both physical and cognitive, is one of the most prevalent and debilitating symptoms of MS that decrease quality of life. Cognitive fatigue presents similarly to sensory overresponsiveness, but the connection has not been explored. Purpose. This study aims to describe how sensory-processing preferences and cognitive fatigue relate to variances in quality of life for people with MS. Method. A cross-sectional design was used with 30 people living with MS to complete the Adolescent/Adult Sensory Profile (AASP), Modified Fatigue Impact Scale, and RAND-36. Spearman’s coefficient measured nonparametric correlations between variables. Findings. People with MS who have high scores in low registration, sensory sensitivity, and sensation avoidant quadrants of the AASP also have higher levels of cognitive fatigue and poorer quality of life. Those with high scores in sensory seeking experience greater quality of life and less cognitive fatigue. Implications. The findings shape clinical practice by supporting the assessment of sensory processing alongside fatigue, offering individualized intervention planning to shape fatigue management, and fostering hope and quality of life for persons living with MS.
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Pohl, Patricia S., Winnie Dunn, and Catana Brown. "The Role of Sensory Processing in the Everyday Lives of Older Adults." OTJR: Occupation, Participation and Health 23, no. 3 (July 2003): 99–106. http://dx.doi.org/10.1177/153944920302300303.
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This study investigated whether there are age-related differences in sensory processing within daily life. Participants included 404 community-dwelling adults divided into three age groups: 19 to 34 years old (127 individuals), 35 to 64 years old (126 individuals), and 65 years and older (151 individuals). Each participant completed the Adolescent/Adult Sensory Profile. There was a difference in sensory processing between the three groups (p = .000), with the older adults noticing sensory input less than the young and middle aged adults (p = .002 for both groups). Both middle aged and older adults engaged in less sensory seeking behaviors than did young adults (p = .012 and p = .000, respectively). In an additional analysis, the older group was subdivided into four age groups (65 to 69 years, 70 to 74 years, 75 to 79 years, and 80 years and older). There was an age-related difference between the four groups (p = .000). Those 75 to 79 years old and those 80 years and older noticed sensory input less than did those younger than 70 years (p = .002 and p = .001, respectively). Those 80 years and older were also less apt to seek sensory experiences than were those younger than 70 years (p = .011). The authors propose hypotheses about the meaning of these findings and provide recommendations for the application of this knowledge to support older adults to age in place successfully.
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Engel-Yeger, B., G. Serafini, X. Gonda, M. Pompili, and M. Amore. "Sensory processing patterns, coping strategies, and quality of life among patients with major affective disorders." European Psychiatry 33, S1 (March 2016): S126. http://dx.doi.org/10.1016/j.eurpsy.2016.01.172.
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IntroductionSeveral studies suggested the involvement of sensory perception in emotional processes and major affective disorders. Similarly, cognitive capacities and coping strategies are reported to influence quality of life of patients with unipolar and bipolar disorders.ObjectivesThe main objective of this study was to investigate the nature of the association between sensory processing patterns, coping strategies, and quality of life among patients with major affective disorders.AimsThe study aimed to compare unipolar/bipolar patients concerning sensory processing, coping strategies and quality of life (QOL); examine correlations between sensory processing and QOL; investigate the relative contribution of socio-demographic characteristics, sensory processing, and coping strategies to the prediction of QOL.MethodsTwo hundred and sixty-seven participants, aged 16–85 years (mean = 53.6 ± 15.7), 157 diagnosed with unipolar major depressive disorder and 110 with bipolar disorder type I and type II completed the Adolescent/Adult Sensory Profile, Coping Orientations to Problems Experienced, and Short Form 12 Health Survey 2.ResultsThe unipolar and bipolar groups did not differ concerning sensory processing, coping strategies, and QOL. Sensory processing patterns correlated with QOL independently of the mediation by coping strategies. Correlations between low registration, sensory sensitivity, sensation avoidance, and reduced QOL were found more frequently in unipolar patients than bipolar patients. Elevated physical QOL was mainly predicted by lower age and lower sensory sensitivity whereas elevated mental QOL was mainly predicted by coping strategies.ConclusionsFuture studies should further investigate the impact of sensory processing and coping strategies on patients’ QOL to enhance adaptive and functional behaviors related to affective disturbances.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Oliveira, Leila Souza, Raquell Alves de Araújo, Candice Abdon Miranda, Elisabeth Silveira Nascimento, Elizandra Cássia de Oliveira, Fátima Maria da Silva Abrão, and Ivson Souza Catunda. "Profile of adolescent victims of violence due to external causes receiving intensive care." Revista de Enfermagem UFPE on line 5, no. 5 (June 25, 2011): 1121. http://dx.doi.org/10.5205/reuol.1302-9310-2-le.0505201106.
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ABSTRACTObjective: to report the epidemiological and clinical characteristics of adolescent victims of violence due to external causes hospitalized in the Intensive Care Units (ICUs) of a hospital in the city of Recife, Pernambuco, Brazil. Method: this is an exploratory and descriptive study, with a prospective design and a quantitative approach. The population was patients admitted to the adult, pediatric, and burn injury ICUs, being the sample composed of 31 victims of violence due to external causes who are between 10 and 19 years old. The data collection technique was a structured interview, and the tool used for this was a questionnaire filled in by the researcher after the approval by the Ethics Committee of the Hospital da Restauracão (Sisnep Protocol - CAAE 0005.0.102.000-09). The data were analyzed through the software Epi-Info 3.5 and presented in figures. Results: thermal burn was the most found external cause, with 38.14%; cranioencephalic trauma, with 23.53%, was the most common secondary diagnosis; and the electrolyte disorders represented 37.04% of the complications found. Conclusion: the profile observed was similar to Brazilian studies that show that external causes constitute an important cause of morbidity among adolescents. Descriptors: violence; adolescents; intensive care unit; external causes; epidemiology.RESUMOObjetivo: relatar as características clínicas e epidemiológicas de adolescentes vítimas de violência por causas externas internados nas Unidades de Terapia Intensiva (UTIs) de um hospital na cidade do Recife-PE. Método: estudo exploratório, descritivo, de caráter prospectivo com abordagem quantitativa. A população foi de pacientes admitidos nas UTIs adulta, pediátrica e de queimados, sendo que a amostra foi de 31 vitimas de violência por causas externas com idades entre 10 e 19 anos. A técnica de coleta dos dados foi uma entrevista estruturada, e o instrumento utilizado foi um questionário preenchido pelo pesquisador após aprovação pelo Comitê de Ética do Hospital da Restauração (Protocolo do Sisnep= CAAE 0005.0.102.000-09). Os dados foram analisados por meio do software Epi-Info 3.5 e apresentados em figuras. Resultados: a queimadura térmica foi a causa externa mais encontrada, com 38,14%; o trauma cranioencefálico, com 23,53%, foi o diagnóstico secundário mais encontrado; e os distúrbios hidroeletrolíticos representaram 37,04% das ocorrências de complicações. Conclusão: o perfil encontrado foi semelhante a estudos brasileiros que comprovam que as causas externas se constituem em importante causa de morbidade entre adolescentes. Descritores: violência; adolescentes; unidade de terapia intensiva; causas externas; epidemiologia.RESUMENObjetivo: presentar los estudios epidemiológicos y clínicos de adolescentes víctimas de la violencia por causas externas internados en las Unidades de Cuidados Intensivos (UCIs) de un hospital en la ciudad de Recife, Pernambuco, Brasil. Método: estudio exploratorio, descriptivo, de carácter prospectivo con abordaje cuantitativa. La población fue de pacientes ingresados en las UCIs adulta, pediátrica y de quemaduras y la muestra estuvo conformada por 31 víctimas de la violencia por causas externas con edades entre 10 y 19 años. La técnica de recolección de datos fue una entrevista estructurada, y el instrumento utilizado fue un cuestionario rellenado por el investigador después de su aprobación por el Comité de Ética del Hospital da Restauração (Protocolo del Sisnep = CAAE 0005.0.102.000-09). Los datos fueron analizados usando el software Epi-Info 3.5 y presentados en figuras. Resultados: la quemadura térmica fue la causa externa más encontrada, con 38,14%; el traumatismo craneoencefálico, con 23.53%, fue el diagnóstico secundario más encontrado; y los trastornos electrolíticos representan 37,04% de las ocurrencias de complicaciones. Conclusión: el perfil fue similar a los estudios de Brasil que muestran que las causas externas constituyen una importante causa de morbilidad entre los adolescentes. Descriptores: violencia; adolescentes; unidad de cuidados intensivos; causas externas; epidemiología.
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Poudel, Pragya G., Hailey E. Bauer, D. Kumar Srivastava, Kevin R. Krull, Melissa M. Hudson, Leslie L. Robison, Zhaoming Wang, and I.-Chan Huang. "Online Platform to Assess Complex Social Relationships and Patient-Reported Outcomes Among Adolescent and Young Adult Cancer Survivors." JCO Clinical Cancer Informatics, no. 5 (August 2021): 859–71. http://dx.doi.org/10.1200/cci.21.00044.
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PURPOSE Social integration and relationship issues have been understudied among adolescent and young adult (AYA) cancer survivors. This study compared social relationships (social networks, support, and isolation) between AYA cancer survivors and noncancer controls, and identified social integration mechanisms through which the cancer experience influences patient-reported outcomes (PROs). MATERIALS AND METHODS One hundred two AYA cancer survivors and 102 age, sex, and race-matched noncancer controls from a national Internet panel completed an online survey to identify up to 25 of closest friends and relatives whom they have contacted within the past 2 years. Participants' interpersonal connections were used to create a social network index. The Duke-UNC Functional Social Support Questionnaire, UCLA Loneliness Scale, and PROMIS-29 Profile were used to measure social support, perceived isolation or loneliness, and PROs (physical functioning, pain interference, fatigue, anxiety, and depression domains), respectively. Path analysis tested effects of cancer experience on PROs using serial social relationship variables as mediators. RESULTS Compared with controls, survivors of lymphoma, leukemia, and solid tumor had better social networks; however, survivors of solid tumor and central nervous system malignancies had higher perceived loneliness (all P values < .05). Cancer experience was directly associated with poor PROs ( P values < .05 for all domains except fatigue) and indirectly associated through the social network-support-loneliness pathway (all P values < .05). Survivors with higher loneliness had lower physical functioning and higher pain interference, fatigue, anxiety, and depression versus controls with lower loneliness (all P values < .05). CONCLUSION Compared with controls, survivors were more socially connected but experienced greater loneliness, which was associated with poorer PROs. Screening social integration issues during follow-up care and providing appropriate interventions are warranted.
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Lee, Oan Na, and Gyeong-A. Park. "The Mediating Effects of Attachment Styles on the Relationship between Sensory Processing Styles and Interpersonal Problems in Healthy University Students." Occupational Therapy International 2020 (May 11, 2020): 1–6. http://dx.doi.org/10.1155/2020/6204120.
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Purpose. Difficulties with sensory processing are known to have negative effects on individuals’ attachment styles and the interpersonal domain. We investigated the relationships among sensory processing styles, attachment styles, and interpersonal problems to better understand the role of attachment styles on the relationship between sensory processing styles and interpersonal problems. Participants. One-hundred and eighty-four university students (aged 18-28 years) completed a set of self-reported measures. Methods. Sensory processing styles, attachment styles, and interpersonal problems were assessed with the Adolescent/Adult Sensory Profile, Experiences in Close Relationships-Revised, and Inventory of Interpersonal Problems-Short Circumplex Form, respectively. Results. Low registration (r=0.587, p<0.001) and sensory avoidance (r=0.501, p<0.001) were positively correlated with interpersonal problems. Regression analyses indicated that low registration (β=0.301, p<0.001) and anxious attachment (β=0.640, p<0.001) were predictors of interpersonal problems (R2=0.672, p<0.001), and sensation avoidance (β=0.386, p<0.001) and avoidant attachment (β=0.233, p<0.001) were predictors of interpersonal problems (R2=0.286, p<0.001). Participants with higher levels of low registration reported higher levels of interpersonal problems, and this relationship was partially mediated by anxious attachment. Participants with higher levels of sensory avoidance reported higher levels of interpersonal problems, and this relationship was partially mediated by avoidant attachment. Conclusions. This study clarifies the relationships between sensory processing styles and interpersonal problems and the mediating effects of attachment styles. The results were discussed in light of the related literature.
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Huang, I.-Chan, Conor Jones, Deo Kumar Srivastava, Melissa M. Hudson, Leslie L. Robison, and Kevin R. Krull. "Association between health status and social integration/loneliness in survivors of adolescent and young adult (AYA) cancers." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e21563-e21563. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21563.
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e21563 Background: AYA cancer survivors are at risk of various adverse health outcomes, but the relation between health status, social integration (i.e., social network and support) and loneliness is understudied. Methods: 102 AYA survivors (mean age = 25 years; diagnoses = leukemia 27%; lymphoma 24%; brain tumors 9%; solid tumors 41%) and 102 age-sex-matched controls were recruited from a community-based online panel. Participants reported social network information (e.g., contact frequency, resources for health counseling) for up to 25 of closest friends/relatives, which was used to create a functional social network index. UCLA Loneliness Scale, Duke-UNC Functional Social Support Questionnaire and PROMIS Health Profile were used to measure loneliness, social support and health-related outcomes (physical functioning, depression, anxiety, fatigue and pain), respectively. Multiple linear regression was used to compare functional social network, social support and loneliness between survivors and controls, and to assess the relation between health outcomes and perceived loneliness. Results: Compared to controls, survivors of lymphoma (b = 1.98; p = 0.005), leukemia (b = 1.67; p = 0.012) and solid tumors (b = 1.22; p = 0.030) had a higher functional social network index. However, social support did not differ between survivors and controls (p’s > 0.05). Brain tumor survivors (b = 15.65; p = 0.006) and solid tumor survivors (b = 10.83; p < 0.001) had more loneliness than controls. Compared to low loneliness controls, high loneliness survivors had significantly lower physical functioning (b = -7.72; p < 0.001) and higher anxiety (b = 8.35; p < 0.001), depression (b = 10.57; p < 0.001), fatigue (b = 5.52; p = 0.011) and pain (b = 6.37; p < 0.001) after adjusting for age, sex, education, social integration, and number of self-reported chronic health conditions. Conclusions: Loneliness is significantly associated with poor health-related outcomes in AYA survivors, which is independent of the influence of social integration. Future research is warranted to understand the relation between health status and social interactions among AYA survivors to inform intervention-based strategies.
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Singh, Swaran, Christine Wright, Eileen Joyce, Tom Barnes, and Thomas Burns. "Developing early intervention services in the NHS: a survey to guide workforce and training needs." Psychiatric Bulletin 27, no. 07 (July 2003): 254–58. http://dx.doi.org/10.1017/s0955603600002531.
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Aims and Method We conducted a questionnaire study to establish the incidence, specialist staff availability, treatment provision and socio-demographic profile of patients with first-episode psychosis referred to all adult and child and adolescent community mental health teams in south and west London. Results All 39 teams completed the questionnaire, identifying 295 cases of first-episode psychosis (annual incidence 21/100 000/year) referred in the year 2000. Teams manage to engage most patients with first-episode psychosis. A total of 73% of cases of first-episode psychosis were on some form of Care Programme Approach. However, many teams did not have adequately trained staff to provide psychosocial interventions. Even where such staff were available, care was focused mainly on monitoring medication and risk assessment, with only half the teams providing psycho-educational programmes and only a quarter offering individual cognitive–behavioural therapy to those with first-episode psychosis. Clinical Implications Establishing early intervention services nationwide will require significant new resources, including specialist trained staff, which could prove difficult to provide in inner-city areas. Rather than a single, uniform service model, several models of early intervention services based on locally determined need might be more realistic and appropriate, and also allow research into their relative efficacy.
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Singh, Swaran, Christine Wright, Eileen Joyce, Tom Barnes, and Thomas Burns. "Developing early intervention services in the NHS: a survey to guide workforce and training needs." Psychiatric Bulletin 27, no. 7 (June 2003): 254–58. http://dx.doi.org/10.1192/pb.27.7.254.
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Aims and MethodWe conducted a questionnaire study to establish the incidence, specialist staff availability, treatment provision and socio-demographic profile of patients with first-episode psychosis referred to all adult and child and adolescent community mental health teams in south and west London.ResultsAll 39 teams completed the questionnaire, identifying 295 cases of first-episode psychosis (annual incidence 21/100 000/year) referred in the year 2000. Teams manage to engage most patients with first-episode psychosis. A total of 73% of cases of first-episode psychosis were on some form of Care Programme Approach. However, many teams did not have adequately trained staff to provide psychosocial interventions. Even where such staff were available, care was focused mainly on monitoring medication and risk assessment, with only half the teams providing psycho-educational programmes and only a quarter offering individual cognitive–behavioural therapy to those with first-episode psychosis.Clinical ImplicationsEstablishing early intervention services nationwide will require significant new resources, including specialist trained staff, which could prove difficult to provide in inner-city areas. Rather than a single, uniform service model, several models of early intervention services based on locally determined need might be more realistic and appropriate, and also allow research into their relative efficacy.
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Machingura, Tawanda, Gurjeet Kaur, Chris Lloyd, Sharon Mickan, David Shum, Evelyne Rathbone, and Heather Green. "An exploration of sensory processing patterns and their association with demographic factors in healthy adults." Irish Journal of Occupational Therapy 48, no. 1 (July 29, 2019): 3–16. http://dx.doi.org/10.1108/ijot-12-2018-0025.
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Purpose Previous research has provided limited evidence on whether and how demographic factors associate with sensory processing patterns (SPP) in adults. This paper aims to examine relationships between SPPs and sociodemographic factors of age, sex, education and ethnicity in healthy adults. Design/methodology/approach A cross-sectional study design was used. A total of 71 adult participants was recruited from the community, using convenience sampling. Each participant completed the Adolescent/Adult Sensory Profile (AASP) and the Depression Anxiety Stress Scales – short version (DASS-21). Demographic information on age, sex, education and ethnicity was collected. Results were analysed using descriptive statistics and multivariate analyses of covariance (MANCOVA). Findings SPPs, as measured by the AASP, were significantly correlated to demographic factors of age and education after controlling for emotional distress using the DASS-21. A statistically significant multivariate effect was found across the four dependent variables (low registration, seeking, sensitivity and avoiding) for the age category, F = 6.922, p = 0.009, ηp2 = 0.145, in the presence of a covariate DASS. The education category showed significance only in the seeking domain (p = 0.008, ηp2 = 0.10) after controlling for DASS. There was no significant correlation between SPPs and gender or ethnicity. Results also indicated that mean scores of participants in this study were “similar to most people” as standardised in the AASP. Research limitations/implications This was a cross-sectional study with limitations including that the study used a relatively small sample and was based on self-reported healthy participants. Practical implications SPPs may correlate with healthy adults’ age and to a lesser extent education. This suggests that it might be helpful to consider such demographic factors when interpreting SPPs in clinical populations, although further research in larger samples is needed to reach firmer conclusions about possible implications of demographic variables. Originality/value The findings in this paper add to the growing evidence that suggest that SPPs vary with sociodemographic factors.
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Matsuoka, Kiwamu, Manabu Makinodan, Soichiro Kitamura, Masato Takahashi, Hiroaki Yoshikawa, Fumihiko Yasuno, Rio Ishida, et al. "Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder." Cerebral Cortex 30, no. 11 (June 9, 2020): 5617–25. http://dx.doi.org/10.1093/cercor/bhaa121.
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Abstract In autism spectrum disorder (ASD), the complexity-specific hypothesis explains that atypical visual processing is attributable to selective functional changes in visual pathways. We investigated dendritic microstructures and their associations with functional connectivity (FC). Participants included 28 individuals with ASD and 29 typically developed persons. We explored changes in neurite orientation dispersion and density imaging (NODDI) and brain areas whose FC was significantly correlated with NODDI parameters in the explored regions of interests. Individuals with ASD showed significantly higher orientation dispersion index (ODI) values in the left occipital gyrus (OG) corresponding to the secondary visual cortex (V2). FC values between the left OG and the left middle temporal gyrus (MTG) were significantly negatively correlated with mean ODI values. The mean ODI values in the left OG were significantly positively associated with low registration of the visual quadrants of the Adolescent/Adult Sensory Profile (AASP), resulting in a significant positive correlation with passive behavioral responses of the AASP visual quadrants; additionally, the FC values between the left OG and the left MTG were significantly negatively associated with reciprocal social interaction. Our results suggest that abnormal V2 dendritic arborization is associated with atypical visual processing by altered intermediation in the ventral visual pathway.
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McCarthy, Linda, Judith Fuller, Georgina Davidson, Alicia Crump, Sandro Positano, and Chris Alderman. "Assessment of yoga as an adjuvant treatment for combat-related posttraumatic stress disorder." Australasian Psychiatry 25, no. 4 (March 1, 2017): 354–57. http://dx.doi.org/10.1177/1039856217695870.
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Objectives: This study assessed yoga as an adjuvant strategy for symptoms of combat-related posttraumatic stress disorder (PTSD). Methods: Subjects had significant, combat-related PTSD. Control data were collected during an eight-week waiting period. Trauma-sensitive yoga sessions of 90 minutes duration were provided every seven days for eight weeks. Assessments included the PTSD checklist (PCL); the Depression, Anxiety and Stress Scale (DASS); the Pittsburgh Sleep Quality Index (PSQI); the Adult/Adolescent Sensory Profile (AASP); the SF36 Quality of Life instrument; and a brief, structured pre-enrolment assessment of attitudes towards yoga. Biomarkers were also assessed. Results: Thirty participants were recruited, with 28 completing the protocol ( Mage=63.5 years). For most variables, there was no significant change in results after the waiting period. Comparing measurements obtained immediately prior to the commencement of the intervention to those taken after completion of eight yoga sessions, significant changes included an increase in the serum dehydroepiandrosterone concentration, decreased total PCL score (and all PCL sub-scales), decreases in all DASS sub-scale scores and significant improvements in PSQI and SF36 scores. No adverse events were reported. Conclusions: A range of benefits were observed after yoga, consistent with the theoretical construct for the long history of yoga as a strategy to reduce stress and promote well-being.
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Goedegebuure, Wesley Jim, Manouk van der Steen, Justine Lenneke de With, and Anita Hokken-Koelega. "Cognition, Health-Related Quality of Life, and Psychosocial Functioning After GH/GnRHa Treatment in Young Adults Born SGA." Journal of Clinical Endocrinology & Metabolism 103, no. 11 (September 20, 2018): 3931–38. http://dx.doi.org/10.1210/jc.2018-01463.
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Abstract Background Children born small for gestational age (SGA) with a poor adult height (AH) expectation benefit from treatment with GH and additional gonadotropin-releasing hormone analog (GnRHa). Because both SGA birth and GnRHa treatment might negatively influence cognition, health-related quality of life (HRQoL), and psychosocial functioning, we assessed these outcomes at AH. Methods A randomized, dose-response GH study until AH involving 99 adolescents born SGA, of whom 61 children received 2 additional years of GnRHa treatment. At AH, the Wechsler Adult Intelligence Scale and TNO-AZL Adults Quality of Life questionnaire were administered to the study group. Additionally, the study group and 67 adolescents born SGA (19 GnRHa) from a second study group completed the Self-Perception Profile of Adolescents and Child/Adolescent Behavior Checklist at AH. Scores in GH-treated young adults with GnRHa treatment (GH/GnRHa group) were compared with GH-treated adolescents without GnRHa treatment (GH group) and a reference population. Results Mean age (SD) at AH was 17.5 (1.2) and 17.4 (1.4) years in the GH/GnRHa and GH group, respectively. Intelligence quotient scores were similar in GH/GnRHa and GH groups (96.33 vs 92.47). HRQoL was similar between both groups and also when compared with the reference population, but the GH/GnRHa group had a significantly lower perception of cognitive functioning. Self-perception and problem behavior were similar in the GH/GnRHa and GH groups. AH did not correlate with HRQoL, self-perception, or problem behavior. Conclusion Combined GH/GnRHa treatment has no long-term negative effects on cognition, HRQoL, self-perception, and behavior in early adulthood, compared with GH treatment only.
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Neufeld, Janina, Lisa Hederos Eriksson, Richard Hammarsten, Karl Lundin Remnélius, Julian Tillmann, Johan Isaksson, and Sven Bölte. "The impact of atypical sensory processing on adaptive functioning within and beyond autism: The role of familial factors." Autism 25, no. 8 (August 2, 2021): 2341–55. http://dx.doi.org/10.1177/13623613211019852.
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Atypical sensory processing is prevalent across neurodevelopmental conditions and a key diagnostic criterion of autism spectrum disorder. It may have cascading effects on the development of adaptive functions. However, its unique contribution to adaptive functioning and the genetic/environmental influences on this link are unclear. In a clinically enriched twin sample ( n = 289, 60 diagnosed with autism spectrum disorder), we investigated the associations between the quadrants of the Adult/Adolescent Sensory Profile (low registration, sensory sensitivity, sensation seeking, and sensation avoiding) and adaptive functioning. Associations were modeled across the cohort accounting for the effects of clinical diagnosis, IQ, sex and age, and within-twin pairs, additionally implicitly adjusting for familial factors. Furthermore, we explored interaction effects between atypical sensory processing and autism spectrum disorder diagnosis. Sensory sensitivity and sensation avoiding were associated with reduced adaptive functioning across individuals, but not within-twin pairs. An interaction effect was found between sensation seeking and autism spectrum disorder diagnosis, showing a negative association between sensation seeking and adaptive functioning only in individuals diagnosed with autism spectrum disorder. The results suggest that atypical sensory processing is associated with reduced adaptive functioning and that familial factors influence this link. In addition, sensation seeking behaviors might interfere with adaptive functioning specifically in individuals with autism spectrum disorder. Lay abstract Individuals diagnosed with autism tend to process sensory information differently than individuals without autism, resulting for instance in increased sensitivity to sounds or smells. This leads to challenges in everyday life and may restrict the individual’s daily functioning. How direct this link is, however, is currently unclear. We investigated this question in 289 twins of whom 60 were diagnosed with autism and further 61 were diagnosed with other neurodevelopmental disorders. We looked at the association between unusual sensory processing and adaptive skills, both across individuals and within-twin pairs, testing whether individuals with higher levels of atypical sensory processing showed reduced adaptive skills compared to their twins. Since twins share 50%–100% of their genes and part of their environment (e.g. family background), associations within-twin pairs are free from effects of these familial factors. We found that an increased sensitivity to, as well as the avoiding of, sensory input (hyper-responsiveness) was linked to reduced adaptive skills across individuals—but not within-twin pairs. We also found an association between the degree to which individuals seek for sensory input (sensation seeking) and reduced adaptive skills, but only in individuals diagnosed with autism. The results suggest that sensory hyper-responsiveness has negative effects on individuals’ general ability to function, but that this link is influenced by familial factors and hence not direct. In addition, sensation seeking behaviors might have a negative impact on adaptive skills specifically in autistic individuals.
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Habib, Rumana, Md Saifuddin, Rashedul Islam, Aminur Rahman, Nirmalendu Bikash Bhowmik, and Md Amirul Haque. "Clinical Profile of Guillain Barre Syndrome-Observations from a Tertiary Care Hospital of Bangladesh." BIRDEM Medical Journal 7, no. 1 (January 24, 2017): 38–42. http://dx.doi.org/10.3329/birdem.v7i1.31270.
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Background: Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%. The aims of this study were to evaluate the demographic and clinical presentation, hospital care and outcome with different modalities of treatment in adult patients suffering from GBSadmittedina tertiary care hospital in Dhaka.Methods: This observational study was done in the Neurology department of a tertiary care hospital in Dhaka.The studystarted in July-2011 and the first fiftypatients suffering from GBSwereenrolledconsecutively. Subjects included in this study were>18years of age.All the patients were interviewed and clinically examined. Relevant data were documented in a structured questionnaire. Nerve conduction Study (NCS) and Cerebrospinal fluid (CSF) study results were also documented. All of patients were watched for respiratory insufficiency and those who developed respiratory paralysis were transferred to ICU for respiratory assistance. According to clinical and electrophysiological criteria, the patients were classified into different variants of GBS. Patients were treated with intravenous immunoglobulin (IVIg), plasmapheresis, supportive care and outcome was observed. The patient who recovered and were discharged were later followed up on out patientbasis for one month Results: The commonest age group affected was 31-50 yrs with male preponderance .The mean age of study subjects was 46years. In most of the patient their weakness progressed for 3-5 days. Clinical evidence of a preceding infection was present inforty-six percent of the patientsbutcausative organism was not identified.Clinical presentations were quadriparesis in 84 % of patients, cranial nerve palsy in 48% of patients. Severe respiratory involvement requiring mechanical ventilation developed in 10% of patientsafter admission. CSF study was done and only10 subjects displayed typical findings of albumino cytological dissociation. NCS wasabnormal in all study subjects and revealed Acute Motor Sensory Axonal Neuropathy (AMSAN) in58%of study population. Among the fifty patients 23received plasmapheresis and another 9 receivedstandard IVIg therapy. Of these patients 20(88%) and 7 (77.6%) patients made significant recovery, respectively. Residual neurodeficit persisted in 6 of the remaining patients who received treatment in the form of only physiotherapy at the end of one month follow-up.Conclusion: Rapidly progressive quadriparesis with cranial nerve involvement was the commonest presentation. In this group of patients NCS proved to be a sensitive study for early diagnosis of patients with GBS in both diabetic and non-diabetic population. The axonal variety of GBS was more common than the demyelinating type. Although not statistically significant, the better response to plasmapheresis seemedencouraging. Again the patients who received IVIg or plasmapheresis early in the course of disease had faster recovery as compared to patients who received only supportive line of treatment.Birdem Med J 2017; 7(1): 38-42
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Brethon, Benoit, Laetitia Morel, Arnaud Petit, Etienne Lengliné, Aurelie Cuinet, Genevieve Vaudre, Thierry Leblanc, et al. "Nelarabine Alone or in Combination in High Risk Childhood / Adolescent and Young Adults (AYA) T- Cell Acute Lymphoblastic Leukemia." Blood 124, no. 21 (December 6, 2014): 3723. http://dx.doi.org/10.1182/blood.v124.21.3723.3723.
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Abstract Introduction: T-cell acute lymphoblastic leukemia (T-ALL) represent 15-20% of childhood/adolescent young adults (AYA) ALL. An intensive chemotherapy is generally needed to obtain the same results than in B-lineage ALL. Day 8 Poor Prednisone Response (PPR) and early resistant disease (refractoriness after induction course or MRD level >10-3 at time point 1 (TP1) and/or TP2) remain particularly challenging as relapses are very difficult to treat especially if they occur early. Nelarabine is a water-soluble prodrug of araG (9-B-arabinofuranosylguanine) which is cytotoxic to T lymphoblasts due to the accumulation of araG nucleotides, especially araGTP, which result in inhibition of ribonucleotide reductase and inhibition of DNA synthesis. Nelarabine was shown to be effective and safe in phase II-III adult and pediatric ALL trials. We describe here a 7 consecutive years experience of nelarabine in “real life” in 3 pediatric / AYA centers. Methods: All children and AYA who received nelarabine in first line therapy or after relapse between 2006 and 2013 were reviewed retrospectively. Classical initial prognostic factors were collected: age, leucocytosis, CNS status, day 8 prednisone response, complete remission (CR) or not, minimum residual disease (MRD) level at TP1 and TP2. Eighty two % of the patients (pts) followed the French FRALLE 2000-T recommendations. Nelarabine, alone or in combination, was used in two groups of pts: group 1: pts in whom nelarabine is given in first line therapy because of high MRD level >10-3 at TP1 and/or TP2 (whatever the level at time of nelarabine infusion) and pts refractory to induction course, and group 2: pts in relapse. Group 1 and 2 are compared for MRD level after nelarabine, number of patients able to go to allogeneic HSCT and overall survival. Finally the safety profile was assessed. Results: 33 T-ALL patients received nelarabine alone (n= 22) or in combination (n= 11, most often with cyclophosphamide and etoposide) from 2006 to 2013. At initial diagnosis, median age was 11.6 y old [3-24], sex ratio 4.5 (M/F 27/6) and median leukocytosis 184.7.109/L [0.1-914]. These patients shared poor risk factors: CNS3 (n=8, 24.1%), D8 PPR (n=23, 69.7%), day 21 M3 bone marrow (n=13, 36.4%), no CR after one induction course (n=6, 18.2%) and MRD level > 10-3 at CR1 (n=15, 42.4%). Regarding group 1 (high MRD level at TP1 and/or TP2 n= 11, refractoriness to induction course n= 5), the status just before nelarabine was: 6 in CR1 with finally MRD <10-3, 5 in CR1 but MRD >10-3 and 5 refractory. Nelarabine was given alone in 12 patients and in combination in 4 patients. MRD level after nelarabine was <10-3 in 12/16 patients. Overall, 11 pts received an allogeneic HSCT and 13/16 (81%) are alive in CR1 at the time of the analysis with a median FU from first nelarabine infusion of 13.7 months [0.8-58.3]. Overall survival is 79.8%+/-10.5 at 5 years. Regarding group 2 (relapsed patients, n= 17), nelarabine was infused at the time of first relapse in 4 patients and in refractory first relapse or more than first relapse in 13 patients. Among these heavily pretreated patients, only 6 obtained a MRD level <10-3 leading to allogeneic HSCT but none of 6 survived. Only one patient survived in CR3 after a success of nelarabine alone and received other chemotherapy without allogeneic HSCT. Regarding toxicities, the only WHO grade III-IV observed side effects are cytopenias (n= 25, 75.8%). Others reported side effects are limited (grade I-II): fever of undetermined origin or infections (n= 7, 21.2%), neurological (n= 6 pts, 18.2%; some of them with more than one side effect: sensory neuropathy in 4, motor neuropathy in 2, headaches in 2, motor-facial neuropathy in 1, ataxia in 1) or muscular (n= 4, 12.1%; 2 myalgia, 1 myositis, 1 amyotrophia), liver toxicities (n= 4, 12.1%; 3 transaminase increases, 1 hyperbilirubinemia). Conclusions: In a non selected population of childhood / AYA high-risk T-ALL, nelarabine was very useful for poor risk patients in first line therapy. The majority of patients received nelarabine as a monotherapy. By contrast nelarabine mostly failed to improve the survival in heavily pretreated relapsed patients. Overall, this study conforts the use of nelarabine in first line T-ALL and high-risk features with acceptable tolerance. The evaluation of nelarabine in selected high-risk patients in a first line setting should be evaluated prospectively to confirm these results. Disclosures Baruchel: JAZZ: Membership on an entity's Board of Directors or advisory committees; ARIAD: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees; Onyx: Membership on an entity's Board of Directors or advisory committees.
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Temmingh, H., D. J. Stein, F. M. Howells, U. A. Botha, L. Koen, M. Mazinu, E. Jordaan, et al. "Biological Psychiatry Congress 2015." South African Journal of Psychiatry 21, no. 3 (August 1, 2015): 24. http://dx.doi.org/10.4102/sajpsychiatry.v21i3.893.
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<p><strong>List of Abstract Titles and authors:<br /></strong></p><p><strong>1. Psychosis: A matter of mental effort?</strong></p><p>M Borg, Y Y van der Zee, J H Hsieh, H Temmingh, D J Stein, F M Howells</p><p><strong>2.In search of an affordable, effective post-discharge intervention: A randomised control trial assessing the influence of a telephone-based intervention on readmissions for patients with severe mental illness in a developing country</strong></p><p><strong></strong>U A Botha, L Koen, M Mazinu, E Jordaan, D J H Niehaus</p><p><strong>3. The effect of early abstinence from long-term methamphetamine use on brain metabolism using 1H-magnetic resonance spectro-scopy (1H-MRS)</strong></p><p>A Burger, S Brooks, D J Stein, F M Howells</p><p><strong>4. The effect of <em>in utero exposure </em>to methamphetamine on brain metabolism in childhood using 1H-magnetic resonance spectroscopy (1H-MRS)</strong></p><p>A Burger, A Roos, M Kwiatkowski, D J Stein, K A Donald, F M Howells</p><p><strong>5. A prospective study of clinical, biological and functional aspects of outcome in first-episode psychosis: The EONKCS Study</strong></p><p><strong></strong>B Chiliza, L Asmal, R Emsley</p><p><strong>6. Stimulants as cognitive enhancers - perceptions v. evidence in a very real world</strong></p><p><strong></strong>H M Clark</p><p><strong>7. Pharmacogenomics in antipsychotic drugs</strong></p><p><strong></strong>Ilse du Plessis</p><p><strong>8. Serotonin in anxiety disorders and beyond</strong></p><p><strong></strong>Ilse du Plessis</p><p><strong>9. HIV infection results in ventral-striatal reward system hypo-activation during cue processing</strong></p><p><strong></strong>S du Plessis, M Vink, J A Joska, E Koutsilieri, A Bagadia, D J Stein, R Emsley</p><p><strong>10. Disease progression in schizophrenia: Is the illness or the treatment to blame?</strong></p><p>R Emsley, M J Sian</p><p><strong>11. Serotonin transporter variants play a role in anxiety sensitivity in South African adolescents</strong></p><p> S M J Hemmings, L I Martin, L van der Merwe, R Benecke, K Domschke, S Seedat</p><p><strong>12. Iron deficiency in two children diagnosed with multiple sclerosis: Report on whole exom sequencing</strong></p><p><strong></strong>S Janse van Rensburg, R van Toorn, J F Schoeman, A Peeters, L R Fisher, K Moremi, M J Kotze</p><p><strong>13. Benzodiazepines: Practical pharmacokinetics</strong></p><p><strong></strong>P Joubert</p><p><strong>14. What to consider when prescribing psychotropic medications</strong></p><p><strong></strong>G Lippi</p><p><strong>15. Current prescribing practices for obsessive-compulsive disorder in South Africa: Controversies and consensus</strong></p><p><strong></strong>C Lochner, L Taljaard, D J Stein</p><p><strong>16. Correlates of emotional and behavioural problems in children with preinatally acquired HIV in Cape Town, South Africa</strong></p><p><strong></strong>K-A Louw, N Phillips, JIpser, J Hoare</p><p><strong>17. The role of non-coding RNAs in fear extinction</strong></p><p><strong></strong>S Malan-Muller, L Fairbairn, W M U Daniels, M J S Dashti, E J Oakleley, M Altorfer, J Harvey, S Seedat, J Gamieldien, S M J Hemmings</p><p><strong>18. An analysis of the management og HIV-mental illness comorbidity at the psychiatric unit of the Dr George Mukhari Academic Hospital</strong></p><p><strong></strong>M L Maodi, S T Rataemane, T Kyaw</p><p><strong>19. The identification of novel genes in anxiety disorders: A gene X environment correlation and interaction study</strong></p><p><strong></strong>N W McGregor, J Dimatelis, S M J Hemmings, C J Kinnear, D J Stein, V Russel, C Lochner</p><p><strong>20. Collaborations between conventional medicine and traditional healers: Obstacles and possibilities</strong></p><p><strong></strong>G Nortje, S Seedat, O Gureje</p><p><strong>21. Thought disorder and form perception: Relationships with symptoms and cognitive function in first-episode schizophrenia</strong></p><p>M R Olivier, R Emsley</p><p><strong>22. Investigating the functional significance of genome-wide variants associated with antipsychotic treatment response</strong></p><p><strong></strong>E Ovenden, B Drogemoller, L van der Merwe, R Emsley, L Warnich</p><p><strong>23. The moral and bioethical determinants of "futility" in psychiatry</strong></p><p><strong></strong>W P Pienaar</p><p><strong>24. Single voxel proton magnetic resonance spectroscopy (1H-MRS) and volumetry of the amylgdala in social anxiety disorder in the context of early developmental trauma</strong></p><p>D Rosenstein, A T Hess, J Zwart, F Ahmed-Leitao, E Meintjies, S Seedat</p><p><strong>25. Schizoaffective disorder in an acute psychiatric unit: Profile of users and agreement with Operational Criteria (OPCRIT)</strong></p><p><strong></strong>R R Singh, U Subramaney</p><p><strong>26. The right to privacy and confidentiality: The ethics of expert diagnosis in the public media and the Oscar Pistorius trial</strong></p><p><strong></strong>C Smith</p><p><strong>27. A birth cohort study in South Africa: A psychiatric perspective</strong></p><p>D J Stein</p><p><strong>28. 'Womb Raiders': Women referred for observation in terms of the Criminal Procedures Act (CPA) charged with fetal abduction and murder</strong></p><p><strong></strong>U Subramaney</p><p><strong>29. Psycho-pharmacology of sleep wake disorders: An update</strong></p><p>R Sykes</p><p><strong>30. Refugee post-settlement in South Africa: Role of adjustment challenges and family in mental health outcomes</strong></p><p><strong></strong>L Thela, A Tomita, V Maharaj, M Mhlongo, K Jonathan</p><p><strong>31. Dstinguishing ADHD symptoms in psychotic disorders: A new insight in the adult ADHD questionnaire</strong></p><p>Y van der Zee, M Borg, J H Hsieh, H Temmingh, D J Stein, F M Howells</p><p><strong>32. Oscar Pistorius ethical dilemmas in a trial by media: Does this include psychiatric evaluation by media?</strong></p><p>M Vorster</p><p><strong>33. Genetic investigation of apetite aggression in South African former young offenders: The involvement of serotonin transporter gene</strong></p><p>K Xulu, J Somer, M Hinsberger, R Weierstall, T Elbert, S Seedat, S Hemmings</p><p><strong>34. Effects of HIV and childhood trauma on brain morphemtry and neurocognitive function</strong></p><p>G Spies, F Ahmed-Leitao, C Fennema-Notestine, M Cherner, S Seedat</p><p><strong>35. Measuring intentional behaviour normative data of a newly developed motor task battery</strong></p><p><strong></strong>S Bakelaar, J Blampain, S Seedat, J van Hoof, Y Delevoye-Turrel</p><p><strong>36. Resilience in social anxiety disorder and post-traumatic stress disorder in the context of childhood trauma</strong></p><p>M Bship, S Bakelaar, D Rosenstein, S Seedat</p><p><strong>37. The ethical dilemma of seclusion practices in psychiatry</strong></p><p>G Chiba, U Subramaney</p><p><strong>38. Physical activity and neurological soft signs in patients with schizophrenia</strong></p><p>O Esan, C Osunbote, I Oladele, S Fakunle, C Ehindero</p><p><strong>39. A retrospective study of completed suicides in the Nelson Mandela Bay Metropolitan Area from 2008 to 2013 - preliminary results</strong></p><p><strong></strong>C Grobler, J Strumpher, R Jacobs</p><p><strong>40. Serotonin transporter variants play a role in anxiety sensitivity in South African adolescents</strong></p><p><strong></strong>S M J Hemmings, L I Martin, L van der Merwe, R Benecke, K Domschke, S Seedat</p><p><strong>41. Investigation of variants within antipsychotic candidate pharmacogenes associated with treatment outcome</strong></p><p>F Higgins, B Drogmoller, G Wright, L van der Merwe, N McGregor, B Chiliza, L Asmal, L Koen, D Niehaus, R Emsley, L Warnich</p><p><strong>42. Effects of diet, smoking and alcohol consumption on disability (EDSS) in people diagnosed with multiple sclerosis</strong></p><p>S Janse van Rensburg, W Davis, D Geiger, F J Cronje, L Whati, M Kidd, M J Kotze</p><p><strong>43. The clinical utility of neuroimaging in an acute adolescnet psychiatric inpatient population</strong></p><p><strong></strong>Z Khan, A Lachman, J Harvey</p><p><strong>44. Relationships between childhood trauma (CT) and premorbid adjustment (PA) in a highly traumatised sample of patients with first-episode schizophrenia (FES</strong>)</p><p>S Kilian, J Burns, S Seedat, L Asmal, B Chiliza, S du Plessis, R Olivier, R Emsley</p><p><strong>45. Functional and cognitive outcomes using an mTOR inhibitor in an adolescent with TSC</strong></p><p>A Lachman, C van der Merwe, P Boyes, P de Vries</p><p><strong>46. Perceptions about adolescent body image and eating behaviour</strong></p><p><strong></strong>K Laxton, A B R Janse van Rensburg</p><p><strong>47. Clinical relevance of FTO rs9939609 as a determinant of cardio-metabolic risk in South African patients with major depressive disorder</strong></p><p>H K Luckhoff, M J Kotze</p><p><strong>48. Childhood abuse and neglect as predictors of deficits in verbal auditory memory in non-clinical adolescents with low anxiety proneness</strong></p><p>L Martin, K Martin, S Seedat</p><p><strong>49. The changes of pro-inflammatory cytokines in a prenatally stressed febrile seizure animal model and whether <em>Rhus chirindensis</em> may attenuate these changes</strong></p><p><strong></strong>A Mohamed, M V Mabandla, L Qulu</p><p><strong>50. Influence of TMPRSS6 A736v and HFE C282y on serum iron parameters and age of onset in patients with multiple sclerosis</strong></p><p><strong></strong>K E Moremi, M J Kotze, H K Luckhoff, L R Fisher, M Kidd, R van Toorn, S Janse van Rensburg</p><p><strong>51. Polypharmacy in pregnant women with serious mental illness</strong></p><p>E Thomas, E du Toit, L Koen, D Niehaus</p><p><strong>52. Infant attachment and maternal depression as predictors of neurodevelopmental and behavioural outcomes at follow-up</strong></p><p>J Nothling, B Laughton, S Seedat</p><p><strong>53. Differences in abuse, neglect and exposure to community violence in adolescents with and without PTSD</strong></p><p><strong></strong>J Nothling, S Suliman, L Martin, C Simmons, S Seedat</p><p><strong>54. Assessment of oxidative stress markers in children with autistic spectrum disorders in Lagos, Nigeria</strong></p><p><strong></strong>Y Oshodi, O Ojewunmi, T A Oshodi, T Ijarogbe, O F Aina, J Okpuzor, O C F E A Lesi</p><p><strong>55. Change in diagnosis and management of 'gender identity disorder' in pre-adolescent children</strong></p><p>S Pickstone-Taylor</p><p><strong>56. Brain network connectivity in women exposed to intimate partner violence</strong></p><p>A Roos, J-P Fouche, B Vythilingum, D J Stein</p><p><strong>57. Prolonged exposure treatment for PTSD in a Third-World, task-shifting, community-based environment</strong></p><p>J Rossouw, E Yadin, I Mbanga, T Jacobs, W Rossouw, D Alexander, S Seedat</p><p><strong>58. Contrasting effects of early0life stress on mitochondrial energy-related proteins in striatum and hippocampus of a rat model of attention-deficit/ hyperactivity disorder</strong></p><p><strong></strong>V Russell, J Dimatelis, J Womersley, T-L Sterley</p><p><strong>59. Attention-deficit hyperactivity disorder in adults: A South African perspective</strong></p><p>R Schoeman, M de Klerk, M Kidd</p><p><strong>60. Cognitive function in women with HIV infection and early-life stress</strong></p><p>G Spies, C Fennema-Notestine, M Cherner, S Seedat</p><p><strong>61. Changes in functional connectivity networks in bipolar disorder patients after mindfulness-based cognitic therapy</strong></p><p>J A Starke, C F Beckmann, N Horn</p><p><strong>62. Post-traumatic stress disorder, overweight and obesity: A systematic review and meta-analysis</strong></p><p><strong></strong>S Suliman, L Anthonissen, J Carr, S du Plessis, R Emsley, S M J Hemmings, C Lochner, N McGregor L van den Heuvel, S Seedat</p><p><strong>63. The brain and behaviour in a third-trimester equivalent animal model of fetal alcohol spectrum disorders</strong></p><p>P C Swart, C B Currin, J J Dimatelis, V A Russell</p><p><strong>64. Irritability Assessment Model (IAM) to monitor irritability in child and adolescent psychiatric disorders.</strong></p><p>D van der Westhuizen</p><p><strong>65. Outcome of parent-adolescent training in chilhood victimisation: Adaptive functioning, psychosocial and physiological variables</strong></p><p>D van der Westhuizen</p><p><strong>66. The effect of ketamine in the Wistar-Kyoto and Sprague Dawley rat models of depression</strong></p><p>P J van Zyl, J J Dimatelis, V A Russell</p><p><strong>67. Investigating COMT variants in anxiety sensitivity in South African adolescents</strong></p><p>L J Zass, L Martin, S Seedat, S M J Hemmings</p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p><strong><br /></strong></p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p>
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Engel-Yeger, Batya, and Sara Rosenblum. "Executive dysfunctions mediate between altered sensory processing and daily activity performance in older adults." BMC Geriatrics 21, no. 1 (February 22, 2021). http://dx.doi.org/10.1186/s12877-021-02032-0.
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AbstractBackgroundSensory processing is essential for the interaction with the environment and for adequate daily function. Sensory processing may deteriorate with aging and restrict daily activity performance. Aging may also affect Executive functions (EFs) which are critical for daily activity performance. Yet, most studies refer separately to the impacts of sensory processing or EFs and use clinical evaluations that do not necessarily reflect functional restrictions in real life. This study aims to describe the prevalence of altered sensory processing in the elderly as expressed in daily life scenarios and explore whether EFs mediate between altered sensory processing and daily activity performance in older adults.MethodsThis cross-sectional study included 167 healthy independently functioning people aged 65 and above who were living in the community, had sufficient cognitive status and no symptoms of depression (based on the GDS and the MMSE). All participants completed a socio-demographic-health questionnaire, the Adolescent/Adult Sensory Profile, the Behavior Rating Inventory of Executive Function–Adult Version and the Daily Living Questionnaire.ResultsAltered sensory processing, and mainly by the reduced ability to register and modulate sensory input from daily environment, were prevalent in older adults. Their impacts on daily activity performance were mediated by executive dysfunctions.ConclusionsExecutive dysfunctions may worsen the negative effects of altered sensory processing on daily activity performance in older adults. The interaction between EFs and sensory processing should receive growing attention in intervention and prevention programs for older adults, with the emphasis on their expressions and implications on peoples’ function in real life context.
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Gafni-Lachter, Liat, Joanna Kailkian, Vered Korngold-Dvir, Gil Dahan, and Ayelett Ben-Sasson. "The association between sensory traits and daily parenting challenges of typical mothers and their children." British Journal of Occupational Therapy, July 17, 2021, 030802262110318. http://dx.doi.org/10.1177/03080226211031800.
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Introduction Sensory modulation impacts daily family life; however, parents’ sensory traits are rarely considered and analysed together with their child’s. This study aimed to: (1) determine the association between healthy child and mother sensory modulation traits and (2) examine how these traits interact in predicting daily parenting challenges. Method Seventy-three healthy mothers of typically developing 3–6-year-old children completed the Short Sensory Profile, Adult/Adolescent Sensory Profile and Parenting Daily Hassles questionnaires. Mother and child sensory over-responsivity (SOR), under-responsivity (SUR) and seeking traits were entered as predictors of frequency of daily hassles. Results Mother and child’s SOR and SUR traits were significantly associated ( r = .33 and .25, respectively). The frequency of parenting challenges was significantly associated with both mother and child’s sensory seeking ( r = .25 and .26, respectively). A mediation model demonstrated a significant indirect effect of mother SOR on the frequency of daily hassles ( β = .26, p < .05), with the child’s SOR ( β = .33, p < .01), and seeking behaviours ( β = .48, p < .001) mediating this effect. Conclusion Mothers with elevated sensory traits of children with elevated sensory traits are likely to experience higher frequencies of daily parenting burden, even within the typical population. Therapists who wish to practice a developmental and family-centred approach should assess how the mother–child sensory traits interact and how this interaction can influence the family’s well-being.
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Zaree, Masoome, Afsoon Hassani Mehraban, Laleh Lajevardi, SeyedHassan Saneii, Zahra Pashazadeh Azari, and Fatemeh Mohammadian Rasnani. "Translation, reliability and validity of Persian version of Adolescent/Adult Sensory Profile in dementia." Applied Neuropsychology: Adult, April 19, 2021, 1–7. http://dx.doi.org/10.1080/23279095.2021.1904927.
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Stern, Brocha Z., Lauren B. Strober, and Yael Goverover. "Relationship between sensory processing patterns, trait anxiety, and health-related quality of life in multiple sclerosis." Journal of Health Psychology, January 29, 2020, 135910531990131. http://dx.doi.org/10.1177/1359105319901316.
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Sensory processing patterns may predict health-related quality of life. This study examined this relationship in persons with multiple sclerosis considering trait anxiety as a potential mediator. Participants ( n = 94) completed the Adolescent/Adult Sensory Profile and other self-report measures at one time point. Sensory processing patterns were significantly associated with trait anxiety and health-related quality of life. Direct and indirect effects of sensory processing patterns were identified on physical health-related quality of life, and indirect effects were identified on mental health-related quality of life. Facilitating adaptive behavioral responses to sensory information may promote health-related quality of life in this population.
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Bahadir, Zeynep, Orkun Aran, and Sedef Şahin. "Cross-cultural adaptation, reliability, and validity of the Turkish Adult Sensory Processing Scale." British Journal of Occupational Therapy, September 7, 2021, 030802262110344. http://dx.doi.org/10.1177/03080226211034413.
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Introduction Sensory processing is crucial to adaptive behavioural responses in occupational therapy. Nevertheless, information on sensory processing in adults is limited. The Adult Sensory Processing Scale (ASPS) measures behavioural responses indicative of sensory processing in different sensory systems. The study aimed to examine the cultural adaptation, reliability and validity of the ASPS-Turkish (ASPS-T). Methods The ASPS-T was administered to 405 individuals, who were aged 18 to 64 (38.5 ± 11.4) years. The cross-cultural adaptation and translation procedures were conducted following Beaton’s guidelines. Internal consistency was examined by Cronbach’s alpha. Criterion-related validity of the ASPS was determined by the Adolescent/Adult Sensory Profile using Construct validity and was examined by confirmatory factor analysis using AMOS. Results The study included 405 participants (271 female and 134 male). Exploratory factor analysis with varimax rotation determined 11 factors with 55.15% total variance. In confirmatory factor analysis (CFA), model fit indices showed an acceptable fit. The reliability of the scale was 0.834, and test–retest reliability changed from 0.94 to 0.99, illustrating high internal consistency and excellent reliability of the scale. Conclusions The ASPS-T is reliable and valid for analysing sensory processing patterns of adults in the Turkish population.
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Ohta, Haruhisa, Yuta Y. Aoki, Takashi Itahashi, Chieko Kanai, Junya Fujino, Motoaki Nakamura, Nobumasa Kato, and Ryu-ichiro Hashimoto. "White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile." Molecular Autism 11, no. 1 (October 19, 2020). http://dx.doi.org/10.1186/s13229-020-00379-6.
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Abstract Background Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether and how white matter alterations are observed in adult populations with developmental disorders (DD) and to determine how brain–sensory relationships are either shared between or distinct to ASD and ADHD. Methods We collected DTI data from adult population with DD (a primary diagnosis of ASD: n = 105, ADHD: n = 55) as well as age- and sex-matched typically developing (TD) participants (n = 58). Voxel-wise fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD) were analyzed using tract-based spatial statistics. The severities of sensory symptoms were assessed using the Adolescent/Adult Sensory Profile (AASP). Results Categorical analyses identified voxel clusters showing significant effects of DD on FA and RD in the posterior portion of the corpus callosum and its extension in the right hemisphere. Furthermore, regression analyses using the AASP scores revealed that slopes in relationships of FA or RD with the degree of sensory symptoms were parallel between the two DDs in large parts of the affected corpus callosum regions. A small but significant cluster did exist showing difference in association between an AASP subscale score and RD across ASD and ADHD. Limitations Wide age range of the participants may be oversimplified. Conclusions These results indicate that white matter alteration and their relationships to sensory symptoms are largely shared between ASD and ADHD, with localized abnormalities showing significant between-diagnosis differences within DD.
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Neufeld, Janina, Mark J. Taylor, Karl Lundin Remnélius, Johan Isaksson, Paul Lichtenstein, and Sven Bölte. "A co-twin-control study of altered sensory processing in autism." Autism, March 1, 2021, 136236132199125. http://dx.doi.org/10.1177/1362361321991255.
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Autism spectrum disorder is associated with sensory processing alterations, such as sensory hyper- and hypo-responsiveness. Twin studies are scarce in this field, but they are necessary in order to disentangle the genetic and environmental contributions to this association. Furthermore, it is unclear how different neurodevelopmental/psychiatric conditions contribute to altering sensory processing. We investigated the association between autistic traits/autism spectrum disorder diagnosis and sensory processing alterations in twins ( N = 269), using the adult/adolescent sensory profile, which differentiates four sub-domains: Low Registration, Sensation Seeking, Sensory Sensitivity, and Sensation Avoiding. While the associations between autistic traits and Low Registration and Sensation Avoiding persisted within monozygotic (genetically identical) twins, Sensory Sensitivity was only associated with autistic traits within dizygotic twins. In multivariate analyses with different neurodevelopmental/psychiatric diagnoses as predictor variables, autism spectrum disorder and attention deficit hyperactivity disorder were the strongest predictors for two adult/adolescent sensory profile sub-domains each. The results suggest that the association between autistic traits and Sensory Sensitivity is influenced by genetics while non-shared environmental factors influence the associations between autistic traits and Low Registration and Sensation Avoiding. They further indicate that altered sensory processing is not specific to autism spectrum disorder, while autism spectrum disorder is a strong predictor of certain sensory processing alterations, even when controlling for other (comorbid) neurodevelopmental/psychiatric conditions. Lay abstract Individuals diagnosed with autism often describe that they process sensory information differently from others, and many experience sensory issues as problematic. For instance, an increased sensitivity to smells or sounds can make participating in social settings challenging. While sensory issues are now part of the diagnostic criteria for autism, they also co-occur with other psychiatric diagnoses such as attention deficit hyperactivity disorder and anxiety disorders. It is unclear to what extent the relationship between autism and alterations in sensory processing are due to genetics or environment. In addition, more research is needed on how autism, as compared to other diagnoses, is associated with sensory issues. Using a twin study, we found that genetic factors influenced self-reported reactivity to sensory stimuli in autism while environmental factors influenced other sensory issues (e.g. difficulties in detecting or differentiating sensory input). Hence, sensory hyper-reactivity might be an early onset core feature of autism, while other domains of alterations in sensory processing might develop later, influenced by the environment. Moreover, autism was more strongly associated with sensory issues related to increased sensitivity/reactivity as compared to other psychiatric diagnoses. However, attention deficit hyperactivity disorder was more strongly related to deficits in detecting/differentiating sensory stimuli and with an increased drive to seek sensory input. Our results indicate that sensory issues are not specific to autism, but that some aspects of altered sensory processing are more relevant for autism than for other diagnoses.