Dissertations / Theses on the topic 'Administration contrôlée de médicaments'
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Yang, QiaoWen. "Systèmes polymériques à base de dispersion aqueuse administrés par voie orale pour la libération contrôlée du principe actif." Lille 2, 2009. http://www.theses.fr/2009LIL2S045.
Blanchemain, Nicolas. "Etude de la biocompatibilité et du greffage de cyclodextrines sur les prothèses vasculaires en PET pour la réalisation d'une prothèse à libération contrôlée de principe actif." Lille 1, 2005. http://www.theses.fr/2005LIL10146.
Prostheses used in vascular surgery (polyester) present a disadvantage: post-operative infections in up to 6 percent of the clinical cases. Based on the knowledge on inclusion properties and grafting of cyclodextrins (CDs), we established the concept of a vascular prosthesis modified with CDs that should be able to absorb antibiotics (ABs), and release them within a prolonged period. The study of the curing parameters allowed us to settle the optimal fixation temperature and time of curing for each four CD. We observed that the finishing reaction did not provoke any degradation of the mechanical properties of the prosthesis; moreover, it contributed to their blood tightness. Biological evaluation confirmed the non-toxicity of grafted surfaces, but proliferation tests revealed a low adaptation of epithelial and endothelial cells on prostheses. In vitro release assessments revealed the presence of all three ABs up to 30 days in water and up to 48 hours in plasma. Compared to virgin prostheses and on the market existing antibiotic impregnated prosthesis, this new prosthesis functionalised with CDs has a significantly prolonged bactericide effect
Abdul-Nour, Faraj. "Étude et conception des pompes implantables mécaniques pour l'administration de médicaments." Compiègne, 1988. http://www.theses.fr/1988COMPD149.
Vagnair, Virginie. "Les contrôles administratifs sur les médicaments." Bordeaux 4, 2003. http://www.theses.fr/2003BOR40042.
Drugs intended for human medicine are potentially dangerous products to public health and must be placed under the permanent control of public authorities. The main objective of the administration is to guarantee the safety of consumers, who must not be faced with mindless health risks. The controls exerted over that are a particular application of the famous precautionary principle. Two types of controls are distinguished. On the one hand, the controls in the sense of constraints weighing on the medicines are various examinations, verifications and appreciations focused on the pharmaceutical specialities throughout their chain, from their conception to their surveillance on the market, having passed through their manufacture, their authorization and their marketing. On the other hand, there are controls which are related to the various responsibilities incurred in the domain of medicines, those that could be harmful
Mimiague, Madeleine. "Les Drug Master Files type I et type II : application à une unité de fabrication d'injectables." Bordeaux 2, 1999. http://www.theses.fr/1999BOR2P072.
Darres, Céline. "Conservation des formes buvables multidoses pédiatriques." Paris 5, 1998. http://www.theses.fr/1998PA05P239.
Elkhoury, Kamil. "Nanofunctionalization and biofabrication of natural hydrogels for tissue engineering applications." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0020.
The main objective of this thesis is to develop a new natural material based on methacrylated gelatin (GelMA) nanofunctionalized by the incorporation of nanoliposomes or soft hybrid exosome-liposome nanoparticles. The physicochemical and biological properties of these hydrogel matrices were characterized in order to evaluate their potential use for tissue engineering applications. GelMA is prepared by the chemical modification of gelatin when methacrylate groups are attached to side groups containing amine functions. In a first part of this work, the influence of the gelatin source (pork or fish) and the degree of methacrylation on the physicochemical and biological properties of hydrogels was studied. In a second part of this work, the GelMA matrix was nanofunctionalized by the incorporation of nanoliposomes, which are soft and natural nanoparticles with remarkable self-assembly properties. These well-established drug delivery systems are formed of lipid bilayers and can transport and release hydrophobic, hydrophilic, and amphiphilic molecules. In this study, naringin, an active molecule that can guide the differentiation process of stem cells to the osteoblastic lineage, was encapsulated in nanoliposomes before their incorporation into the GelMA polymeric matrix in order to develop a system of interest for bone regeneration applications. This nanocomposite material was physicochemically and biologically characterized and the release profile of naringin was investigated. In a third and final part of this work, the GelMA matrix was nanofunctionalized by the incorporation of exosome-liposome soft hybrid nanoparticles. Exosomes, natural nanovesicles secreted by cells, are of increasing interest for targeted drug delivery applications due to the presence of cell specific receptors on their surface. The hybrid GelMA hydrogels were physicochemically and biologically characterized for applications in cardiac reprogramming and was successfully bioprinted and microfabricated. Biofabricated GelMA hydrogels nanofunctionalized with nanoliposomes or hybrid exosome-liposome nanoparticles are promising platforms for the controlled release of bioactive molecules and for tissue engineering applications
Padula, Cristina. "Patch-non-patch® : film polymérique pour la délivrance contrôlée des médicaments." Lyon 1, 2005. http://www.theses.fr/2005LYO10036.
Ongkasin, Kanjana. "Elaboration de dispositifs médicaux ophtalmiques à libération contrôlée de médicaments par imprégnation supercritique." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0536.
Supercritical CO2 technologies are arisen as green and eco-responsible alternatives for drug formulation and medical device processing. The present PhD work aims to develop innovative ocular therapeutic medical devices to mitigate two post-operative complications of cataract surgery, endophthalmitis and posterior capsule opacification. Among other processes, supercritical impregnation was selected to load commercially available intraocular lenses (IOLs) commonly used in cataract surgery with ophthalmic drug components. A targeted action of drug molecules can be therefore achieved through a sustained release directly at the potential affected zones without requiring subsequent medical interventions. Supercritical impregnation of foldable hydrophobic acrylic IOLs was studied by varying the operating conditions of pressure (8 to 25 MPa), temperature (308 to 328 K) and impregnation duration (30 to 240 min). The influence of using ethanol as a co-solvent was also evaluated. In vitro drug release kinetics were studied and used to determine the impregnation yields. In order to rationalize the influence of the concomitant phenomena governing impregnation, thermodynamic behaviors of the involved systems, polymer/CO2 and drug/CO2 were studied. {Ex vivo} implantation of methotrexate impregnated IOLs on human donor capsular bags shown fibrosis reduction by inhibiting epithelial-mesenchymal transformation highlighting the potential of the innovative sustained-release drug-delivery IOLs to become of clinical relevance
Veaux, Adeline. "Zones à atmosphère contrôlée et eau purifiée dans l'application de la maîtrise de la contamination." Paris 5, 1998. http://www.theses.fr/1998PA05P021.
Ades, Emmanuelle. "Administration pernasale des médicaments à effet systémique." Paris 5, 1993. http://www.theses.fr/1993PA05P234.
Delplace, Céline. "Microparticules à libération contrôlée : nouveaux polymères et importance des conditions de libération." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S007.
Poly(lactic-co-glycolic) acid (PLGA)-based microparticles represent an attractive choice to sustain drug release over periods ranging from a few days up to several months, while ensuring good biocompatibility and complete biodegradability. Recently, tremendous efforts have been devoted to improve the properties of these copolymers by introducing functional groups along the polymeric chain, with the aim of modulating the drug release.On the one hand, the main objective of this work was to investigate the potential application of new functionalized copolymers bearing pendant carboxyl groups (PLA-co-PBED), as controlled drug delivery device. In this study, apomorphine was encapsulated as a model drug. Its therapeutic effect is limited due to its very short half-life and its strong emetic effect. Consequently, biodegradable microparticles would offer the advantage of improving therapeutic efficiency and compliance, by reducing administration frequency and minimizing systemic side effects. Apomorphine-loaded, PLA-co-PBED-based microparticles were prepared using an emulsion method. Microparticles based on PLGA 50:50 of different molecular weights were used as a reference. The obtained microparticles were characterized using various techniques. The residual content of dichloromethane (used as organic phase during microparticle preparation) was quantified and the in vitro release of apomorphine was studied. Interestingly, the functionalized polymers bearing free-carboxylic groups led to higher drug encapsulation efficiencies, lower residual contents of dichloromethane and different drug release patterns. These results suggest a promising application of these functionalized polymers to control drug release. Furthermore, the impact of the formulation parameters on the resulting physico-chemical properties of microparticles was studied. The main objective was to optimize the encapsulation efficiency, while minimizing initial burst release, to avoid toxic concentration peaks, and thus potential side effects. In this matter, some formulation parameters were varied during the preparation of microparticles based on PLGA 50:50 of 10 kDa. Optimal parameters were selected to achieve a zero-order apomorphine release over 10 days.On the other hand, it is well known that the in vitro drug release studies are crucial for the development of PLGA-based microparticles. However, as no standardized method has yet been established by authority agencies, very different methods are used in practice and their consequences on the resulting drug release kinetics are not well understood. Consequently, this work was intended to evaluate the impact of the experimental conditions on the resulting drug release kinetics from PLGA-based microparticles. Frequently applied setups were used. Different model drugs were encapsulated at different initial drug loadings. Various techniques were used to characterize the resulting formulations. Mathematical modeling was applied to better understand the observed phenomena. These results showed that the impact of the experimental conditions can be negligible or significant, depending on the type of formulation and the experimental setup. The observed differences could partially be explained by differences in the underlying drug release mechanisms. It can be concluded that great care must be taken when drawing conclusions from in vitro drug release measurements
Moussa, Iskandar. "Diffusion dans les matrices hydrophiles à base d'amylose réticulé, caractérisation et application à la libération contrôlée de médicaments." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0007/NQ39769.pdf.
Nicoli, Sara. "Administration dermique et transdermique des médicaments : deux cas d'étude." Paris 11, 2002. http://www.theses.fr/2002PA114804.
Jordao, Eduardo. "L'adaptation de l'intensité du contrôle juridictionnel aux caractéristiques de l'action administrative contrôlée." Thesis, Paris 1, 2014. http://www.theses.fr/2014PA010310.
No English summary available
Ducharme, Claire. "Impact d'un programme d'auto-administration des médicaments en gériatrie active." Mémoire, Université de Sherbrooke, 2000. http://savoirs.usherbrooke.ca/handle/11143/2248.
Estebe, Jean-Pierre. "Évaluation pré-clinique de systèmes thérapeutiques microparticulaires à libération contrôlée de bupivacaine dans les techniques d'anesthésie loco-régionale périphérique." Rennes 1, 2001. http://www.theses.fr/2001REN1BA55.
Dufès, Christine. "Vectorisation centrale du peptide vasoactif intestinal (VIP) : étude par administration nasale et par administration systémique de niosomes ciblés." Poitiers, 2002. http://www.theses.fr/2002POIT2332.
Illel, Brigitte. "Contribution à l'étude de la pénétration cutanée des particules : mise au point de deux méthodes d'étude quantitative des voies de pénétration transépidermiques et transfolliculaires." Paris 11, 1990. http://www.theses.fr/1990PA114804.
Paul, Alexis. "Validation d'une caisse isotherme pour le transport d'un produit de biotechnolgie en température contrôlée entre +2 et +8oC." Paris 5, 2001. http://www.theses.fr/2001PA05P013.
Blanchon, Sylvène. "Méthodologie d'étude pharmacotéchnique pour l'élaboration de systèmes transdermiques : application à la progestérone et à un progestatif de synthèse." Paris 11, 1991. http://www.theses.fr/1991PA114801.
Khalid, Mohamed Nabil. "Synthèse, caractérisation, stérilisation et étude des propriétés de réseaux à base de chitosane : application à la libération contrôlée pour l'administration orale et comme enrobage pour des prothèses endovasculaires." Paris 11, 2002. http://www.theses.fr/2002PA114812.
Brochart, Hervé. "Étude de la diffusion d'un principe actif à travers une membrane polymérique poreuse constituée de non-tissé : application au développement d'un système réservoir à libération contrôlée destiné à un usage vétérinaire." Paris 11, 1994. http://www.theses.fr/1994PA114807.
Bravo, Anaya Lourdes Mónica. "Étude du comportement d'ADN en solution et aux interfaces et le rôle de la dynamique micellaire et la rhéologie dans la libération contrôlée de médicaments." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAI112/document.
Nowadays, the target for reaching a greater efficiency in DNA compaction processes, the innovation ofDNA sensors development and the study of changes in the interfacial properties generated between metalsurfaces and DNA molecules has become an area of great interest in bioengineering. This section of thethesis proposes the coupling of rheological, electrochemical and optical techniques to perform a detailedstudy of DNA molecules behavior in the bulk state of the solution and at the interface with two differentmetallic surfaces, as a function of parameters such as temperature, DNA concentration and electricpotential. Firstly, the rheological behavior of DNA/buffer solutions, as well as the evidence of the criticalconcentrations (C★ and Ce) is discussed from simple steady state and oscillatory dynamic shearexperiments. After studying DNA solutions properties, electrochemical and optical techniques are used toidentify structural changes in Au/DNA and Pt/DNA interfaces and to describe the arrangement of DNAchains in the electrochemical double-layer as a function of concentration and within each characteristicregime, i.e. dilute and semi-dilute regimes. The obtained response trough Electrochemical ImpedanceSpectroscospy (EIS), Modulation Interfacial of the Capacitance (MIC) and Surface Plasmon Resonance(SPR) techniques reflects an adsorption process of DNA molecules taking place onto the metal surfaces.Finally, by selecting DNA concentrations in the dilute regime, we studied the formation of chitosan-DNAnanoparticles with defined stoichiometry for gene transfer.The specific delivery of active ingredients, known as vectorization, has actually become a greatchallenge in therapeutic research. This process has been used to control the distribution of activeingredients such as proteins, genes for gene therapy and drugs, to a target by associating it with avector. Molecules for chemotherapy are frequently hydrophobic and require vectorization to betransported to the target cell. In this section of the thesis, we look up to understand the collectiveexchange dynamics (fusion and fission) between amphiphilic block copolymer micelles at the equilibriumand out of the equilibrium, and the exchange dynamics between these micelles (representing vectors)and the simplest model of cells (liposomes). We used a fluorescent technique with hydrophobic pyrenederivative to probe the fusion and fission of micelles at equilibrium. After characterizing amphiphilicblock copolymers structure and studying their dynamics in and out of equilibrium, we proposed a timescan fluorescence technique to quantify the collective vectorization dynamics between amphiphilic blockcopolymer micelles and liposomes. The effect of the variation of several parameters such as liposomeconcentration and a chitosan adsorption were investigated in order to control the vectorizationdynamics between these vectors and cells models
Beesh, Mustafa. "Mise au point de nouvelles formulations pharmaceutiques orales à délivrance ciblée de principes actifs au niveau du côlon." Strasbourg, 2010. https://publication-theses.unistra.fr/public/theses_doctorat/2010/BEESH_Mustafa_2010.pdf.
The work described in this manuscript deals with the synthesis, the enzymatic degradation and the physicalchemistry characterization of new excipients based on a natural polysaccharide, dextran. These excipients can serve coating or agent matrix for the realization of oral pharmaceutical forms at colon-specifie release of the active ingredients. To this end, two main strategies for syntheses were performed on dextran to make it hydrophobie. The first is based on the esterification of hydroxyl groups of dextran to prepare three families of dextran esters (acetate, propionate and butyrate) with three Degree of substitution (1 , 2 and 3). The second strategy allows to obtain three types of dextran block copolymers (di, tri and tetra-block copolymers) by freeradical emulsion polymerization of one or more acrylic monomers (MA, MMA and MAA) on the block of dextrans. The beneficial results of in vitro release of theophyllin from tablets coated individually with different types of dextran block copolymers were allowed to determine the potential uses of dextran block copolymers to deliver oral dosage forms in the colon
Cirany, Muriel. "Dispensation informatisée des médicaments : essai de l'automate de dispensation Sure-Med de la société Baxter." Paris 5, 1999. http://www.theses.fr/1999PA05P066.
Bounoure, Frédéric. "Formulation d'un médicament à base de métopimazine." Rouen, 2006. http://www.theses.fr/2006ROUENR06.
Metopimazine is an antiemetic drug with many galenic forms which are not adapted to treat nauseas/ vomiting associated to a diarrhéa in thechildren. Two ways were followed in this study to admnistrate this drug : the cutaneous route and the nasal one. The study of percutaneous absoption was led on pig skin using Franz cell and showed a flow of 0,176 µg/h/cm². The absoption enhancers (ethanol, propylene glycol, isopropyl myristate) have a factor 32. Iontophoresis contitutes however a much better solution with percutaneous flow of 4. 72 µg/h/cm². The study of the nasal route was led in rabbit and demonstrated an important absoption of metopimazine with a bioavailabilitu of 50%. Cyclodextrin was tested lihke an absorption enhancer and its addition increased the maximum plasmatic concentration of metopimazine. In conclusion, the nasal route is most interesting with an important absorption allowed a therapeutic use and a quick effect
Aubert, L'Huillier Carole. "Evaluation du pouvoir bioadhésif de gels à base de techniques "in vitro" : étude de l'influence des facteurs de formulation - choix de la méthode." Paris 5, 1997. http://www.theses.fr/1997PA05P142.
Gontard, Gwenaëlle. "Synthèse de nanoconjugués PEG-PLA pour des applications biomédicales : libération contrôlée et Imagerie." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30279.
This PhD thesis is based on a joint between Sanofi in Vitry-sur-Seine and LHFA. This work consists in the development of new nanovectors based on biodegradable and biocompatible polymerics conjugate that enable to encapsulate, transport and deliver therapeutic agents. Previous works in the laboratory have shown that the release of hydrophobic drugs, such as Cabazitaxel, a taxane derivative, could be controlled by the architecture of the conjugated PEG-PLA. In the first chapter, a study was realized to improve the release kinetics of the drug, taking advantage of the difference of pH between healthy and cancerous tissue. Different linkers (linking the drug to the copolymer) having a pH dependent behavior have been studied, such as hydrazone, acetal and β-thiopropionate. The boronic ester bonding, dynamic function of pH, was also studied in order to destroy the NP and indirectly improve the release of drug. The synthesis and the evaluation of various conjugates have shown that the amphiphilic polymeric structure of the conjugates significantly inhibited the expected pH-dependent behavior. In the second chapter, several technologies such as targeting or imaging were studied. The influence of the Y and L-shape on the recognition and imaging properties was analyzed. The Y-shape offers advantages like the amount of ligand required for optimal active targeting and better visualization, in comparison with the results obtained with the L conjugates. The method of co-nanoformulation allowed to adjust the ligand amount or imaging probe within the NPs. In the third chapter, the synthesis and efficiency of (bi)pyridinium salts as catalysts for the ROP of ε-caprolactone are presented. A collaborative behavior with dication bipyridiniums is bearing two hydrogen bonds (IHBD) was demonstrated for the activation of the ε-caprolactone, with greater ROP activities compared to systems involving the participation of only one H bond. The best systems were evaluated in more details and allowed access to polymers with a molecular weight of up to 13 000 g / mol
Aubin, Christel. "Dispositifs transdermiques : actualisation." Paris 5, 1998. http://www.theses.fr/1998PA05P109.
Eouani, Adam César. "Etude comparative du potentiel mucoadhésif de films de polymère à effet matriciel." Aix-Marseille 2, 2001. http://theses.univ-amu.fr.lama.univ-amu.fr/2001AIX22953.pdf.
Muschert, Susanne. "Polymeric coatings for solid dosage forms : characterization and optimization." Lille 2, 2008. http://www.theses.fr/2008LIL2S023.
Martinet, Frédéric. "Qualification d'un appareil pour essai de dissolution des formes orales solides." Paris 5, 1999. http://www.theses.fr/1999PA05P023.
Hoarau, Didier. "Etude de la potentialité d'héparines hydrophobisées pour la microencapsulation moléculaire et la promotion de l'absorbtion intestinale de principes actifs récalcitrants." Montpellier 1, 2003. http://www.theses.fr/2003MON13517.
Plasson, François. "Aide à la prescription et à l'administration des médicaments en gériatrie." Paris 5, 1996. http://www.theses.fr/1996PA05P087.
Correia, José. "Synthèse, caractérisation et propriétés de copolymères dérivés du poly(chlorure de vinyle) analogues a l'héparine." Paris 13, 1995. http://www.theses.fr/1995PA132035.
Collaveri, Jean-Pierre. "Etude des timbres transdermiques : évaluation d'une formulation adaptée à un principe actif x." Paris 5, 1990. http://www.theses.fr/1990PA05P051.
Ben, Azzouz Seifeddine. "Libération contrôlée d'un neuroleptique par voie orale en utilisant des capsules hybrides PLGA-PEG / Alginate/." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC116.
Currently therapeutic treatments for schizophrenia, intravenously or orally, are only partially effective and generally associated with extrapyramidal effects often dangerous and very troublesome for patients. In order, to increase the treatment efficiency by neutralizing any side effects the aim of this work was to design composite capsules (PLGA-PEG / alginate) intended to be administered by way oral and able to release locally, in a specific and controlled way, the neuroleptic “haloperidol” in the brain. The optimization of the protocol of synthesis allowed to obtain in a reproducible way of the nanocapsules of monodisperse and not very aggregate porous PLGA, having an average hydrodynamic diameter lower than 80 Nm and a good stability in aqueous solution. Once functionalized with Poly (ethylene glycol) diamine, in vitro studies showed the low toxicity of these furtive nanoparticles as well as their ability to encapsulate a satisfactory amount of haloperidol and release this active principle over a period of one month with a low burst effect. The incorporation of the PEGylated nanoparticles in matrices prepared with a high concentration of alginate and 100% CaCl2 made it possible to obtain nanocomposite beads having a better stability at the exit from the simulated gastric medium and persist approximately 30 minutes in simulated intestinal medium. Finally, preliminary in vivo studies on adult mice using injected nanoparticles and ingested nanocomposite balls showed the effectiveness of these systems to deliver haloperidol in the brain
Quellec, Patricia. "Nanosphères "furtives" à base de copolymères biodégradables pour la libération contrôlée de principes actifs hydrophobes et de protéines." Vandoeuvre-les-Nancy, INPL, 1997. http://www.theses.fr/1997INPL133N.
Paineau, Virginie. "Prescription et utilisation de médicaments dans un service de long séjour de gériatrie." Paris 5, 1997. http://www.theses.fr/1997PA05P104.
Cauchetier, Emmanuelle. "Systèmes vectorisés pour une administration parentérale de l'atovaquone : application au modèle murin de leishmaniose viscérale." Paris 11, 2002. http://www.theses.fr/2002PA114808.
Greib, Nicolas. "Administration par voie péritonéale de médicaments au cours de la coeliochirurgie : intérêt de la nébulisation d'anesthésique local." Strasbourg, 2010. http://www.theses.fr/2010STRA6174.
The boom in laparoscopic surgery means that new anesthetic strategies must be found, especially with respect to post-operative analgesia. Topical administration of local anesthetics is part of multimodal analgesia and many studies seeking to establish its interest in laparoscopic surgery provide contradictory results. Our aim is to contribute to an optimum way of administrating local anesthetics topically, with a view to: 1)homogeneous spreading on the peritoneum, 2)simultaneous humidification of insufflation gas, in order to prevent hypothermia. Hypothermia is due to evaporation of the peritoneum’s surface by contact with dry insufflation gas. Humidification could prevent this thermal energy loss. We performed several in vitro and in vivo (animal-) studies. Firstly, we evaluated the efficiency of hot versus cold humidification in hypothermia prevention. Secondly, we evaluated several humidification devices in order to assess their efficiency in delivering ropivacaine in the insufflation gas flow. Finally, we performed a pharmacokinetic study of intraperitoneal ropivacaine nebulization, by comparison with standard instillation. Our results open new prospects for intraperitoneal topical administration of local anesthetics: in the animal setting, we showed that hot humidification of insufflated gas did not provide any benefit in hypothermia prevention, in comparison with cold humidification, we established the potential value of a nebulizer, able to humidify and deliver local anesthetics along with CO2 insufflation during laparoscopy, we performed the first pharmacokinetic study of intraperitoneal ropivacaine nebulization, validating the safety of the technique. These results enable us to follow our research with a clinical trial to evaluate the effects of nebulized ropivacaïne and humidified insufflation gas in laparoscopic surgery
Glówka, Eliza. "Encapsulation des sondes fluorogéniques et de molécules pharmacologiquement actives dans des nanoparticules pour augmenter la capture cellulaire." Thesis, Nancy 1, 2009. http://www.theses.fr/2009NAN10065/document.
Polymeric nanoparticles have been considered to have the potential to improve drug delivery to the desired site of action and to enable delivery of poorly soluble, poorly absorbed or unstable drugs. In this work, two types of active substances have been chosen for encapsulation in polymeric nanoparticles: fluorogenic probes for intracellular targeting of the reduced glutathione (GSH), namely ortho-phthaldialdehyde (OPA) and naphthalene-2,3-dicarboxaldehyde (NDA), as well as salmon calcitonin (sCT) which is a polypeptide hormone. The probe or sCT-loaded nanoparticles were obtained using a simple or double emulsion solvent evaporation method, respectively. The obtained nanoparticles were thoroughly characterized, e.g. in terms of the size, zeta potential, encapsulation efficiency, drug (probe) release, cytotoxicity or microscopic morphology and thermal properties. NDA-loaded nanoparticles were incubated with yeast cells and intracellular NDA-GSH adduct levels increased by about 9-times in comparison with the free probe. In the case of sCT, the in vivo study was conducted in rats, and it was demonstrated that after subcutaneous injection of sCT-loaded nanoparticles, elevated serum sCT levels could be sustained for 3 days. In conclusion, the active molecules incorporated in polymeric nanoparticles achieved the better cellular uptake (NDA) and bioavailability (sCT) that the non encapsulated ones
Bou, Haidar Naila. "Développement d’un pansement à libération contrôlée d’une protéine spécifique anti-biofilm bactérien. Application aux plaies chroniques." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR087.
Bacterial biofilms are a major obstacle to the wound healing process. In addition, they are responsible for the emergence of resistance and tolerance to antibiotics. Hence, the development of controlled drug delivery systems targeting the bacterial biofilm appears as an urgent and essential alternative therapeutic approach for the effective management of chronic wound. In this work, we developed wound dressings in which a protein, dispersin B (DB), is released capable of selectively targeting the biofilm matrix, creating a deleterious microenvironment for the bacterial biofilm. To this end, we were interested in asymmetric membranes (AMs) from biodegradable polyesters such as the poly(3-hydroxybutyrate-co-4-hydroxybutyrate), the poly (butylene succinate-co-butylene adipate) (PBSA) and the polylactic acid. By the incorporation of hydrophilic porogen agents (PA), we were able to obtain AMs with a high level of porosity, exhibiting a porous interconnected network and oxygen and water vapor permeability. Using bovine serum albumin as a model protein, we demonstrated that protein loading and release from the PBSA AMs were affected by the membrane structure and the presence of residual PA. In vitro studies showed highest antibiofilm efficiency both in inhibition and dispersion (up to 80%). Normalized in vitro cytotoxicity standard assays revealed that unloaded and DB-loaded PBSA membranes met cytocompatibility criteria required for wound dressing applications
Carvalho, Bouton Malua de. "Modélisation de l'absorption percutanée ex vivo de l'œstradiol." Lyon 1, 1995. http://www.theses.fr/1995LYO1T094.
Tedajo, Gilberte-Muriel. "Emulsions multiples de type H/L/H : des véhicules prometteurs pour l'administration d'antiseptiques par voie vaginale." Paris 11, 2002. http://www.theses.fr/2002PA114811.
Schlotterbeck, Hervé. "Conditionnement du CO2 insufflé lors des cœlioscopies : Intérêt de l'humidification sans réchauffement." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13122.
Machet, Laurent. "Utilisation des ultrasons pour augmenter l'absorption percutanée : la phonophorèse." Tours, 1997. http://www.theses.fr/1997TOUR3308.
Czuba, Elodie. "Développement de nouveaux systèmes nanoparticulaires pour l'administration de bio-médicaments par voie orale." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ072/document.
Biologics are administrated by parenteral route due to their degradation in the gastrointestinal tract. This administration mode leads to lowadherence, showed by the low adherence for chronic diseases treatment. In order to increase adherence by reducing pain and adverse effects associated with treatment we developed a double encapsulation system to protect and increase biologic absorption for a future oral administration. Our system consists in encapsulated biologics inside PLGA nanoparticles (NPs), themselves encapsulated inside a gastroresistant vehicle. The aim of this work was to improve the system efficiency with insulin by NPs charges modification and intestinal release reduction and to transfer the technology to another molecule: the heparin. Negative charges improved the intestinal nanoparticle crossing as shown by the insulinopenic rat model with a decrease of glycaemia. To stabilize the NPs system in intestinal medium, a hyaluronic acid coating was tested and validated in vitro. When transferred to another biologics, we showed similar NPs chacacteristics with heparin than with insulin, revealing the transposition of our technic
Reix, Nathalie. "Administration orale d'insuline : validation in vitro et in vivo d'un système basé sur une double encapsulation de l'insuline." Strasbourg, 2009. http://www.theses.fr/2009STRA2495.
The purpose of this study was to develop a new formulation of oral insulin. Normally, peptide hormones like insulin are given by parenteral injections routes because they are destroyed by the acid and proteolytic enzymes in stomach and intestine. Our project focuses on insulin double encapsulation for oral administration. The first system of encapsulation of insulin is based on Poly(Lactide-co-Glycolide) Acid (PLGA) nanoparticles. This should allow the uptake and the transport across mucosal intestinal barrier. These nanoparticles are put in a gastroresistant capsule made of Eudragit® L100-55. After synthesis, the size of nanoparticles is 165 ±4 nm and the rate of encapsulation is around 95%. In vitro, the absorption has been quantify by flow cytometry and visualized by confocal microscopy. A clathrin dependant endocytosis pathway mechanism has been demonstrated. In vivo, the biofunctionnality of the nanoparticles was evaluated after subcutaneous injections. After nanoparticles gastric force feeding no effect was seen on the glycemia because nanoparticles are not gastroresistant. We measured the kinetic of the glycemia and the biofunctionnality of NP in streptozotocin-induced diabetic rats after intra-duodenal injections of insulin nanoparticles and intraperitoneal injections of insulin. The bioavaibility was evaluated after quantification of the C-peptidemia after intra-peritoneal injections of C-peptide and after intraduodenal injections of the same quantity of encapsulated C-peptide. Intraduodenal injections of insulin nanoparticles induce a significant decrease of glycemia 8h after injection. In comparison with intra-peritoneal injections, results showed that nanoparticles’ biofunctionnality is at less 20% and the biodisponibility is 6,3%. PLGA insulin-loaded nanoparticles are efficient and the biological effect of insulin is preserved. These polymeric particles allow the absorption of insulin through intestinal mucosa into the bloodstream. Thus this new delivery insulin formulation seems to be an interesting approach