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Engelsoy, Julius. "Considerations Regarding AdS2 Backreaction and Holography." Thesis, KTH, Fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210245.
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Voronkova, Valentina Vladimirovna. "ADH2 repression : a genetic and biochemical approach /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9221.
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Scaramuzzino, Giuseppe. "Definition and Standardization of ADS2 Ltd Manufacturing Processes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
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L’elaborato realizzato nei sei mesi di tirocinio per tesi svolto presso l’azienda ADS2 Brands Limited con sede a Biggleswade (UK) è il frutto di un lavoro di osservazione, analisi e intervento sui processi produttivi aziendali.
Lo scopo del progetto era quello di definire, ottimizzare e standardizzare i processi produttivi per poi giungere alla stesura di un set di documentazione tecnica da condividere con l’ufficio tecnico, con il project manager e con il plant manager.
L’azienda è specializzata nella realizzazione di componentistica per gli impianti di spillamento delle bevande, quindi si tratta di una produzione fortemente personalizzata.
La principale tecnologia di produzione è quella di stampaggio per iniezione con l’utilizzo di diverse tipologie di materiali termoplastici, ad esempio ABS, PMMA, Polipropilene. A questo processo tecnologico che coinvolge la maggior parte della produzione si affiancano altre tecnologie quali termoformatura, stampa digitale e tradizionale, oltre che alle attività di realizzazione degli stampi.
Sono stati osservati numerosi cicli di fabbricazione, rilevandone tempi, caratteristiche dei materiali, tasso di impiego delle risorse (in termini di operatori, macchinari, attrezzature, materiali) e qualità dei componenti realizzati. Tutti i dati rilevati in fase di analisi sono stati analizzati e confrontati con quelli già presenti sul gestionale Microsoft Dynamics 365.
Di ogni componente, sono state rilevate le criticità in fase di produzione, di altre eventuali lavorazioni o di assemblaggio e si è cercato di fornirne delle soluzioni praticabili.
Molti processi sono stati ottimizzati secondo la filosofia del Lean Manufacturing e si è giunti alla realizzazione del set di documentazione prevista: scheda macchina, scheda di processo e scheda di prodotto.
A margine di ciò sono state proposte delle soluzioni per quanto riguarda l’organizzazione del magazzino, l’identificazione dei tool e l’impiego di risorse per ridurre i lead time.
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Iannone, Lucio. "ADMA metabolism and chronic hypoxia-induced pulmonary hypertenstion." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24911.
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Rationale: Elevated asymmetric dimethylarginine (ADMA) levels contribute to the pathogenesis of hypoxia-induced pulmonary hypertension. Chronic hypoxia decreases the activity of the enzymes metabolising ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) but the mechanisms responsible are not understood. Objective: To elucidate the physiological significance and the mechanism of hypoxia-induced downregulation of ADMA metabolism. Methods and Results: Exposure of human pulmonary artery endothelial cells (HPAECs) to hypoxia inhibited both DDAH1 and DDAH2 gene and protein expression, reduced DDAH activity and increased ADMA levels. In contrast, in human pulmonary artery smooth muscle cells (HPASMCs) only DDAH2 was reduced while ADMA levels remained unchanged. This endothelium-specific regulation of DDAH1 and ADMA resulted from NFκB-dependent, microRNA-21 (miR-21)-mediated degradation of DDAH1 mRNA. Down regulation of DDAH1 activity contributed to hypoxia-induced endothelial barrier dysfunction and HPASMC proliferation and was prevented by overexpression of DDAH1 and miR-21 blockade. Conversely, overexpression of miR-21 mimicked the effects of hypoxia. DDAH1 overexpressing transgenic mice exposed to 2 weeks hypoxia, showed attenuated pulmonary hypertension and vascular remodelling, compared with wildtype controls. Importantly, inhibition of miR21 in vivo prevented the hypoxia-induced reduction in pulmonary DDAH1 expression and attenuated the development of pulmonary hypertension. Lung tissue samples from hypoxic mice and treatment-naïve IPAH patients also showed reduced DDAH1 expression and increased miR-21 levels, compared with controls. Conclusion: Down regulation of DDAH1 expression by miR-21 in the pulmonary vascular endothelium has a key role in the pathogenesis of hypoxia-induced pulmonary hypertension and may be of broader significance in pulmonary hypertension.
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Queen, André Sampaio. "Simulador de reatores anaeróbios com base no ADM1." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/3/3139/tde-04092006-170243/.
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Primeiramente, esse trabalho pretende esclarecer a importância de pesquisas em modelagem, simulação e controle nos processos de tratamento de efluentes e apontar o atraso do Brasil nesta área de pesquisa comparado ao avanço das iniciativas internacionais. O trabalho apresenta o problema específico da modelagem dos processos anaeróbios e propõe uma nova ferramenta de simulação de regime permanente para esses sistemas, desde digestores de lodo a reatores UASB. O simulador se baseia no ADM1 (Anaerobic Digestion Model No 1), modelo proposto pela IWA em 2002, e está implementado em C++. A intenção é disponibilizar livremente um software de simulação com o diferencial de uma metodologia e interface gráfica amigável, capaz de trazer para o dia-a-dia do profissional da área toda a sofisticação de uma modelagem mais completa, tanto do ponto de vista microbiológico como físico-químico. A metodologia proposta se mostrou muito eficiente para a obtenção da condição de regime permanente, fazendo com que a caracterização do afluente se tornasse a etapa limitante do processo de simulação. O método desenvolvido é tão eficaz que permite que sejam realizadas simulações com afluentes e reatores hipotéticos, tornando possível estudos desvinculados da necessidade de análises laboratoriais complexas ou fora do comum.First, this work intends to show the importance of research in modeling, simulation and control of wastewater treatment processes, and to point the delay of our country (Brazil) in this subject, compared to the advance of the international initiatives. This work presents the specific problem of modeling the anaerobic digestion and proposes a new tool to simulate the steady state condition in anaerobic reactors. The simulator is based on the ADM1 (Anaerobic Digestion Model No 1), developed by IWA in 2002, and is implemented in C++. The intention is to give free access to a new simulation software with the advantages of better methodology and friendly graphical interface. This tool should be able to bring to the professionals all the sophistication of a more complete modelling in the microbiological and physical-chemical point of view. The developed methodology revealed itself to be very efficient for the attainment of the steady state condition. Consequently, it makes the characterization of the influent the critic stage of the simulation process. The developed method is so efficient that allows simulation studies to be carried out using hypothetical influents and reactors. Thus, it brings independence for simulation studies with no need of complex or unusual laboratorial analyses.
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Tejkl, Jakub. "Trvanlivost destiček ADMX při frézování materiálů skupiny S." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231383.
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This diploma thesis studies the machining of group S materials. In the theoretical part of this thesis these materials were divided into groups and subsequently analyzed. These materials were also analyzed in terms of their impaired machinability. In the practical part of this thesis experimental tests were conducted to determine tool life, tool wear and in the case of testing titanium alloy surface roughness too.
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Tomlinson, James. "The role of DDAH and ADMA in kidney disease." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24541.
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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis and elevated plasma levels associate with poor cardiovascular and renal outcomes. The dimethylarginine dimethylaminohydrolase enzymes (DDAHs; 1 and 2) metabolise ADMA. A DDAH1 gene variant associates with higher kidney tissue mRNA expression, lower plasma ADMA but counter-intuitively, a steeper rate of eGFR decline. This indicates that renal DDAH1 activity may be deleterious and circulating ADMA does not necessarily reflect the NO-ADMA balance (or severity of disease) within kidney tissue. This study tests the hypothesis that reduced renal DDAH1 activity protects against the progression of kidney function decline, independent of circulating ADMA. Renal DDAH1 expression predominates within the proximal tubule. A novel proximal tubule-specific DDAH1 knock-out (PTD1KO) mouse was developed, which demonstrated tubule-specific dysregulation of ADMA and NO that was not evident systemically. Phenotyping studies in PTD1KO mice did not identify consistent alterations of urinary biochemistry at baseline or after salt loading, however, proteomic analysis revealed significant alterations of urinary peptides at baseline; including down-regulation of uromodulin and collagen. At 12 weeks following folate renal injury, the PTD1KO mouse exhibited less kidney function decline, collagen deposition and pro-fibrotic gene expression (Col12alpha, TGFbeta and ET-1) than controls. Furthermore, ADMA and DDAH1 inhibition reduced tubular sodium and fluid reabsorption in rat microperfusion studies, although studies in PTD1KO mice failed to reproduce this effect. Finally, in vitro studies using a PT cell line and primary PT culture indicated an inhibitory effect of ADMA upon PT cell proliferation. Consistent with recent human genetic studies, these data provide experimental evidence indicating a reduction of renal tubule DDAH1 activity can protect against progressive kidney fibrosis and function decline, independent of plasma ADMA. This work provides novel insights into the role of the NO-ADMA-DDAH axis within the kidney, particularly the tubule.
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Annergren, Mariette. "Application-Oriented Input Design and Optimization Methods Involving ADMM." Doctoral thesis, KTH, Reglerteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-187890.
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This thesis is divided into two main parts. The first part considers application-oriented input design, specifically for model predictive control (MPC). The second part considers alternating direction method of multipliers (ADMM) for ℓ1 regularized optimization problems and primal-dual interior-point methods. The theory of system identification provides methods for estimating models of dynamical systems from experimental data. This thesis is focused on identifying models used for control, with special attention to MPC. The objective is to minimize the cost of the identification experiment while guaranteeing, with high probability, that the obtained model gives an acceptable control performance. We use application-oriented input design to find such a model. We present a general procedure of implementing application-oriented input design to unknown, possibly nonlinear, systems controlled using MPC. The practical aspects of application-oriented input design are addressed and the method is tested in an experimental study. In addition, a MATLAB-based toolbox for solving application-oriented input design problems is presented. The purpose of the toolbox is threefold: it is used in research; it facilitates communication of research results; it helps an engineer to use application-oriented input design. Several important problems in science can be formulated as convex optimization problems. As such, there exist very efficient algorithms for finding the solutions. We are interested in methods that can handle optimization problems with a very large number of variables. ADMM is a method capable of handling such problems. We derive a scalable and efficient algorithm based on ADMM for two ℓ1 regularized optimization problems: ℓ1 mean and covariance filtering, and ℓ1 regularized MPC. The former occurs in signal processing and the latter is a specific type of model based control. We are also interested in optimization problems with certain structural limitations. These limitations inhibit the use of a central computational unit to solve the problems. We derive a distributed method for solving them instead. The method is a primal-dual interior-point method that uses ADMM to distribute all the calculations necessary to solve the optimization problem at hand.QC 20160602
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Forgey, Cady. "Prevention of Chronic Inflammation by Targeting Macrophage Integrin aDb2." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3849.
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Macrophage integrin aDb2 promotes macrophage retention and accumulation within inflamed tissue, a key event in development of chronic inflammation. Recently, the P5 peptide was identified as a specific inhibitor for integrin aDb2 interaction with 2-(ω-carboxyethyl) pyrole (CEP), a ligand at inflammatory sites. This thesis aims to identify integrin aD I-domain amino acids involved in binding P5 peptide and likewise to CEP. We propose that non-conserved, basic amino acids of the integrin aDb2 I-domain are responsible for binding to P5 peptide and likewise to CEP. Eight amino acids were analyzed by generating six mutant aD I-domains: K180[A], R189[Q], K205[L], HHK223-225[NIT], K233[A], and K246[A]. Mutagenic constructs were created using PCR site-directed mutagenesis, then transformed into E.coli BL21 cells for IPTG-induced protein expression. Of the 6 mutant I-domains analyzed, amino acid K246 was critical in binding to P5 peptide and CEP through ForteBio Protein-Protein Assay, as well as to CEP by cell adhesion assay.
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Abboud, Azary. "Optimisation distribuée dans les grands systèmes interconnectés avec ADMM." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLC004/document.
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Cette thèse porte sur la construction des algorithmes distribués pour l’optimisation de la production et du partage de ressources au sein d’un réseau de large dimension. Notamment, on se concentre sur les réseaux électriques et les réseaux cellulaires 5G. On considère dans le cas des réseaux électriques le problème OPF (Optimal Power Flow) dans lequel on vise à faire la gestion et l’optimisation de la production de l’énergie électrique d’une manière distribuée. On se concentre sur une version linéarisée du problème, la DC-OPF (Direct-Current Optimal Power Flow). Comme le problème d’optimisation est convexe dans ce cas, on vise à minimiser le coût de production de l’énergie tout en respectant les limites des lignes de transmission et les contraintes caractéristiques du système. Dans le cas des réseaux cellulaires, on formule un problème de Caching. On a pour but de réduire l’utilisation du backhaul liant les stations de base et le contrôleur du réseau. Les stations de base sont équipées d’une capacité de stockage limitée. Ils visent à trouver d’une manière optimale les fichiers à stocker dans le but de réduire une certaine fonction de coût sur l’utilisation du backhaul et sur le partage des fichiers avec les autres stations de base. L’approche adoptée dans cette thèse consiste à appliquer l’ADMM (Alternating Direction Method of Multipliers), une méthode d’optimisation de manière itérative, à un problème d’optimisation que l’on a préalablement reformulée de façon adéquate. Ce problème permet à la fois de décrire le DC-OPF et le problème de Caching. On démontre la convergence de cette méthode quand elle est appliquée noeud par noeudd’une manière totalement distribuée. Ainsi que dans le cas où le réseau est divisé en plusieurs zones. Ces zones peuvent se chevaucher mais aussi elles peuvent être séparées ou indépendantes. De plus, dans le contexte d’un réseau à zones, on démontre que l’application de l’ADMM d’une manière aléatoire par une seule zone converge aussi vers la solution optimale du problèmeThis thesis focuses on the construction of distributed algorithms for optimizing resource production in a large interconnected system. In particular, it focuses on power grid and 5G cellular networks. In the case of power grid networks, we consider the OPF (Optimal Power Flow) problem in which one seeks to manage and optimize the production of electrical energy in a distributed manner. We focus on a linearized version of the problem, the DC-OPF (Direct- Current Optimal Power Flow) problem. This optimization problem is convex; the aim is to minimize the cost of energy generation while respecting the limits of the transmission line and the power flow constraints. In the case of 5G cellular networks, we formulate a caching problem. We aim to offload the backhaul link usage connecting the small bases stations (SBSs) to the central scheduler (CS). The SBSs are equipped with a limited storage capacity. We seek to find the optimal way to store files so as to reduce the cost on the use of backhaul and sharing files with other SBSs. The approach adopted in this thesis is to apply the ADMM (Alternating Direction Method of Multipliers), an optimization method that is applied iteratively, to an optimization problem that we adequately formulated previously. This problem can both describe the DC-OPF problem and the Caching problem. We prove the convergence of the method when applied node by node in a fully distributed manner. Additionally, we prove its convergence in the case where the network is divided into multiple areas or nations that may or may not overlap. Furthermore, in the context of a network with multiple areas, we show that the application of ADMM in a random manner by a single randomly chosen area also converges to the optimal solution of the problem
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Carrigan, Matthew A. "The reason we drink alcohol is rooted in our evolution." Revista de Química, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/99743.
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Gracias a la resurrección de varias enzimas de nuestros antepasados primates se han identificado varias mutaciones que ocurrieron hace, aproximadamente, 10 millones de años, las cuales le confirieron a nuestros antepasados una capacidad mucho mayor para metabolizar etanol. Este episodio de evolución enzimática coincidió con un cambio climático global asociado con la reducción de los bosques africanos y la transición de nuestros antepasados de un estilo de vida arbórea a un estilo de vida terrestre en el cual la fruta altamente fermentada era más común. Estos estudios sugieren que la evolución de las enzimas de nuestros antepasados pueden haberles permitido explotar una fuente alternativa de alimento cuando la comida era escasa.We have resurrected ancient enzymes from our primate ancestors and identified several mutations occurring approximately 10 million years ago that endowed our ancestors with an enhanced capacity to metabolize ethanol. This episode of enzyme evolution coincided with a global climate change associated with shrinking African forests and our ancestor’s transition from an arboreal lifestyle to a terrestrial lifestyle where highly fermented fruit is more common. These studies suggest that the evolution of our ancestor’s enzymes may have enabled our ancestors to exploit an alternative source of nourishment during a time when food was scarce.
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Bagli, Maria Chiara. "ll metodo ADMM per la regolarizzazione con Variazione Totale Generalizzata." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20966/.
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La tesi tratta del Metodo dei Moltiplicatori a Direzione Alternata (ADMM) per il problema di ricostruzione di immagini con il funzionale di Variazione Totale Generalizzata (TGV). Tale funzionale è convesso e dipende da due parametri positivi reali il cui valore influenza la qualità dell'immagine ricostruita. Parte del lavoro di tesi è stato dedicato al settaggio dei parametri, in particolare alla scelta del parametro di regolarizzazione, dei due parametri da cui dipende il funzionale TGV e dai parametri specifici del metodo ADMM. Si è compiuta un'analisi comparativa tra il metodo ADMM e il metodo PDAL originariamente proposto per la ricostruzione di immagini mediante TGV. I risultati numerici su diversi problemi test mostrano che il metodo ADMM risulta più performante sia in termini di qualità di ricostruzione che in termini di efficienza computazionale. Infine si è studiato come i parametri specifici per il metodo ADMM influenzino la qualità dell'immagine ricostruita e si è proposto un range nel quale scegliere i valori di tali parametri.
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Piolanti, Simone. "Il formalismo ADM per la metrica FLRW." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
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Il tema centrale di questo elaborato è la cosmologia, affrontata in ambito di relatività generale applicando il formalismo ADM al modello FLRW. Il problema consiste nella risoluzione delle equazioni di Einstein in presenza di materia. Sfruttando quindi il formalismo ADM sono innanzitutto definite le formulazioni lagrangiana ed hamiltoniana di una teoria in ambito di relatività generale. In particolare sono descritte tali formulazioni per le equazioni di Einstein. Segue come applicazione l'esempio della particella libera relativistica interpretata come teoria di campo in una dimensione. È infine trattato il caso di interesse: si considera la metrica FLRW per universo piatto e sono risolte le equazioni di Einstein calcolate a partire da un'azione in cui la materia è descritta da un campo scalare senza massa di minimo accoppiamento.
Il risultato ottenuto descrive due possibili universi: uno in espansione e uno in contrazione. In particolare, l'evoluzione del fattore di scala rispetto al tempo proprio del sistema è descritto dalla relazione α^3 (τ)=α^3 (0)(1±τ/τ_c).
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Wronka, Gerd. "Die Integration adenoviraler DNA in das Genom der Wirtszelle Untersuchung der Verknüpfungsstellen zwischen adenoviraler DNA und Säuger-DNA in einem zellfreien System zur integrativen Rekombination und genomische Lokalisierung von adenoviralen Sequenzen in Ad2- und Ad12-transformierten Zellinien /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965016331.
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jaafar, hussein amez. "AGING AND DECISION MAKING AS MEASURED BY THE SWEDISH VERSION OF THE ADMC BATTERY." Thesis, Umeå universitet, Institutionen för psykologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68356.
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The aim of this study was to examine age-related differences in decision-making competence. The study is a part of the ongoing Betula project (Nilsson et al., 1997; 2004), and the data included test results from (N, 364) corresponding to the questionnaires with complete responses (>80%) to the items addressed. The Swedish version of the Adult Decision-Making Competence (A-DMC) battery was used. An exploratory factor analysis of the A-DMC data yielded a two-component solution: The A-DMC tasks were divided into Factor 1 (Applying Decision Rules, Resistance to Framing and Consistency in Risk Perception tasks), and Factor 2 (Under/Overconfidence, Resistance to Sunk Costs and Recognizing Social Norms). These two factors showed opposite age effects, where Factor 1 (analytic decision making) declined with age, whereas Factor 2 (heuristic decision competence) was not negatively affected by old age.Betula Project
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Hasan, Abdallah Khalil Abdallah. "The role of educational leadership in providing quality culture at ADMC." Thesis, University of Lincoln, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400804.
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Nguyen, Hoa Huu. "Modelling of food waste digestion using ADM1 integrated with Aspen Plus." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/375082/.
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The aim of this research was to produce an integrated modelling platform in which an anaerobic digester could be linked to the other unit operations which serve it, both in maintaining the physical-chemical conditions in the digester and in transforming the digestion products to useful fuel and nutrient sources. Within these system boundaries an accurate mass and energy balance could be determined and further optimised, particularly where the desired energy products are a mix of heat, power, and biomethane. The anaerobic digestion of food waste was choosen as the subject of the research because of its growing popularity and the availability of validation data. Like many other organic substrates, food waste is potentially a good source of renewable energy in the form of biogas through anaerobic digestion. A number of experimental studies have, however, reported difficulties in the digestion of this material which may limit the applicability of the process. These arise from the complexity of the biochemical processes and the interaction between the microbial groups that make up the anaerobic community. When using food waste there is a tendency to accumulate intermediate volatile fatty acid products, and in particular propionic acid, which eventually causes the pH to drop and the digester to fail. Two factors are important in understanding and explaining the changes in the biochemical process that leads to this condition. The first is due to the differential in sensitivity to free ammonia of the two biochemical pathways that lead to methane formation. The acetoclastic methanogenic route is inhibited at a lower concentration than the hydrogenotrophic route, and methane formation therefore occurs almost exclusively via acetate oxidation to CO2 and H2 at high free ammonia concentrations. The accumulation of propionic acid is thought to be because formate, a product of its degradation, cannot be converted to CO2 and H2 as the necessary trace elements to build a formate dehydrogenase enzyme complex are missing. The Anaerobic Digestion Model No. 1 (ADM1) was modified to reflect ammonia inhibition of acertoclastic methanogenesis and an acetate oxidation pathway was added. A further modification was included which allowed a 'metabolic switch' to operate in the model based on the availability of key trace elements. This operated through the H2 feedback inhibition route rather than creating a new set of equations to consider formate oxidation in its own right: the end result is, however, identical in modelling terms. With these two modifications ADM1 could simulate experimental observations from food waste digesters where the total ammoniacal nitrogen(TAN) concentration exceeded 4 gN l-1. Under these conditions acetate accumulation is first seen, followed by proprionate accumulation, but with the subsequent decrease in acetate until a critical pH is reached. The ADM1 model was implemented in MATLAB with these modifications incorporated. The second part of the research developed an energy model which linked ADM1 to the mechanical processes for biogas upgrading, Combined Heat and Power (CHP)production, and the digester mixing system. The energy model components were developed in the framework of the Aspen Plus modelling platform, with sub-units for processes not available in the standard Aspen Package being developed in Fortran, MS Excel or using the Aspen Simulation Workbook (ASW). This integration of the process components allows accurate sizing of the CHP and direct heating units required for an anaerobic digestion plant designed for fuel grade methane production. Based on the established model and its sub-modules, a number of case studies were developed. To this end the modified ADM1 was applied to mesophilic digestion of Sugar Beet Pulp to observe how the modified ADM1 responded to different substrate types. Secondly, to assess the capability of adding further mechanical processes the model was used to integrate and optimise single stage biogas upgrading. Finally, the digestion of food waste in the municipal solid waste stream of urban areas in Vietnam was considered.
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Silva, Flávio Gonzaga Castro Santos. "Modelização dinâmica do processo de digestão anaeróbia utilizando o modelo ADM1." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/548.
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Mestrado em Engenharia do AmbienteO presente trabalho propõe a aplicação de um modelo dinâmico para descrever o processo de tratamento anaeróbio, baseado no modelo ADM1. O estudo de modelização compreendeu a designação de variáveis implicadas no processo biológico, a implementação computacional, em duas plataformas informáticas distintas, das equações cinéticas que o descrevem e ainda a verificação do seu desempenho através de simulações para diferentes cenários, entre os quais um ensaio laboratorial semi-contínuo estudando a degradação anaeróbia de um efluente específico gerado numa indústria de pasta de papel pelo processo ao sulfito. Uma análise de incerteza efectuada ao modelo permitiu identificar os parâmetros que mais influenciam o comportamento das variáveis simuladas: a taxa máxima de degradação de acetato (km_ac), o factor de conversão de acetato em biomassa (Y_ac) e a constante de semi-saturação de degradação do acetato (Ks_ac). Após uma estimação destes parâmetros, o modelo foi validado com base no ajuste das simulações a resultados experimentais resultantes da operação laboratorial de um segundo reactor anaeróbio semi-contínuo, utilizado para o estudo de uma condição alimentada distinta – a degradação anaeróbia do mesmo efluente, com adição suplementar de uma fonte de carbono externa. Conclui-se que o modelo simula relativamente bem a maioria das variáveis implicadas no processo específico de degradação – eficiência de remoção de matéria orgânica, produção de metano, etc. -, apesar destas revelarem alguma sensibilidade a alguns dos parâmetros especificados nas equações do processo anaeróbio. Em geral, nas cargas orgânicas mais elevadas, o modelo desenvolvido tende a desviar-se ligeiramente dos valores de algumas variáveis de estado, subestimando a eficiência de remoção de matéria orgânica. Será necessário proceder a uma calibração mais exacta para tornar possível a aplicação prática das simulações, recorrendo a dados reais. O esforço de modelização constitui assim uma ferramenta que pode ser utilizada na previsão do desempenho de operações de tratamento anaeróbio à escala industrial, quer em condições estacionárias, quer em condições de elevada variação de carga orgânica. Através da simulação é possível desenvolver prognósticos detalhados e estratégias de controlo de reactores anaeróbios que, de outra forma, só poderiam ser determinadas por medições experimentais dispendiosas e demoradas. ABSTRACT: This work presents the application of a dynamic model describing the anaerobic treatment process, based on ADM1 model. The modelling study consisted of setting the biological process variables, the computational implementation of its kinetic equations into two different software applications, as well as model verification by simulating it for different frameworks, one of those was the laboratorial operation of a semi-continuous assay testing the anaerobic degradation of an effluent generated in a sulphite pulp mill. An uncertainty analysis permitted the identification of the most influential parameters on the behaviour of simulated variables: maximum specific acetate uptake rate (km_ac), yield of biomass on acetate (Y_ac) and half-saturation constant for acetate uptake (Ks_ac). After parameter estimation, the model was validated by means of the simulation fitting to experimental data sets from the laboratorial operation of a second semi-continuous reactor, used for studying a different feed condition – the anaerobic degradation of the same effluent using an external carbon source addition. It was concluded that the model simulates quite well some of the variables implied on the specific degradation process – organic matter removal, methane production, etc. -, although they revealed some sensitivity to a large number of parameters embedded on the anaerobic process equations. In general, in the higher organic loads, the implemented model trends to deviate slightly the values for several state variables, underestimating the organic matter removal efficiency. It is then necessary to accurately calibrate the mathematical model on existing real data in order to be possible the application of the simulation results in practice. The modelling efforts can be a valuable tool predicting the performance at fullscale treatment operations, either in steady-state conditions, or in changeable organic load conditions. Through simulation it is then possible to develop detailed prognosis and control strategies for several influent characteristics and operation conditions in the anaerobic reactors, which otherwise could only be determined by time-consuming and expensive measurement phases.
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Schulze, Karen [Verfasser]. "Prognostische Bedeutung von asymmetrischem Dimethylarginin (ADMA) beim akuten Myokardinfarkt / Karen Schulze." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2011. http://d-nb.info/101391340X/34.
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Canault, Baptiste. "Développement d'une plateforme de prédiction in silico des propriétés ADME-Tox." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2048/document.
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Dans le cadre de la recherche pharmaceutique, les propriétés relatives à l’Absorption, la Distribution, le Métabolisme, l’Elimination (ADME) et la Toxicité (Tox) sont cruciales pour le succès des phases cliniques lors de la conception de nouveaux médicaments. Durant ce processus, la chémoinformatique est régulièrement utilisée afin de prédire le profil ADME-Tox des molécules bioactives et d’améliorer leurs propriétés pharmacocinétiques. Ces modèles de prédiction, basés sur la quantification des relations structure-activité (QSAR), ne sont pas toujours efficaces à cause du faible nombre de données ADME-Tox disponibles et de leur hétérogénéité induite par des différences dans les protocoles expérimentaux, ou encore de certaines erreurs expérimentales. Au cours de cette thèse, nous avons d’abord constitué une base de données contenant 150 000 mesures pour une cinquantaine de propriétés ADME-Tox. Afin de valoriser l’ensemble de ces données, nous avons dans un deuxième temps proposé une plateforme automatique de création de modèles de prédiction QSAR. Cette plateforme, nommée MetaPredict, a été conçue afin d’optimiser chacune des étapes de création d’un modèle statistique, dans le but d’améliorer leur qualité et leur robustesse. Nous avons dans un troisième temps valorisé les modèles obtenus grâce à la plateforme MetaPredict en proposant une application en ligne. Cette application a été développée pour faciliter l’utilisation des modèles, apporter une interprétation simplifiée des résultats et moduler les observations obtenues en fonction des spécificités d’un projet de recherche. Finalement, MetaPredict permet de rendre les modèles ADME-Tox accessibles à l’ensemble des chercheursAbsorption, Distribution, Metabolism, Elimination (ADME) and Toxicity (Tox) properties are crucial for the success of clinical trials of a drug candidate. During this process, chemoinformatics is regularly used to predict the ADME-Tox profile of bioactive compounds and to improve their pharmacokinetic properties. In silico approaches have already been developed to improve poor pharmacokinetics and toxicity of lead compounds. These predictive models, based on the quantification of structure-activity relationships (QSAR), were not always efficient enough due to the low number of accessible biological data and their heterogeneity induced by the differences in experimental assays or the significant experimental error. In this thesis, we first built a database containing 150,000 data points for about 50 ADME-Tox properties. In order to valorize all this data, we then proposed an automatic platform for creating predictive models. This platform, called MetaPredict, has been designed to optimize each step of model development, in order to improve their quality and robustness. Third,, we promoted the statistical models using the online application of MetaPredict platform. This application has been developed to facilitate the use of newly built models, to provide a simplified interpretation of the results and to modulate the obtained observations according to the needs of the researchers. Finally, this platform provides an easy access to the ADME-Tox models for the scientific community
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Claros, Santiago Carlos Eduardo, Portugal Julio Raul Corcuera, Espinoza Maribel Martina Cuenca, Garaycochea Pablo Rafael Cárdenas, Aguila Peralta Irma Del, Frias Bruno Alberto Rivas, Boada Julio Cromwell Ubillús, and Fajardo Soraya Katia Yrigoyen. "Globalización: Enfoque cultural y económico (Adm.) - HU65 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/624404.
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Descripción: El curso promueve un espacio de discusión y diálogo en el que los estudiantes se aproximan, desde
perspectivas relacionadas a los ámbitos de la cultura y la economía, al estudio de las principales características y
manifestaciones del proceso de globalización en los negocios internacionales, tanto en el mundo contemporáneo
como en nuestro país.
Propósito: Contribuir con la formación del pensamiento crítico de los estudiantes, motivándolos a consultar
diversas fuentes de información e interpretaciones sobre el tema, muchas veces confrontadas entre sí, para
explicar los factores que dieron origen a la globalización contemporánea y vislumbrar sus principales
consecuencias hacia el futuro. Al finalizar el semestre se espera que los alumnos hayan asumido una postura
crítica sobre este tema, característica necesaria para poder afrontar con éxito los diferentes retos de cualquier
profesional. El requisito de este curso supone haber aprobado Mundo Contemporáneo HU160.
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Bercevič, Renata. "Antilipideminėmis savybėmis pasižyminčių vaistinių augalų veikliųjų medžiagų palyginamoji apžvalga ir raudonųjų dobilų (Trifolium pratense L.) žolės pritaikymo mažinti cholesterolio kiekį kraujyje pagrindimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110628_151406-22258.
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Darbo tikslas – apžvelgti Lietuvoje augančių antilipideminėmis savybėmis pasižyminčių augalų pritaikymo galimybes mažinti cholesterolio kiekį kraujyje bei pagrįsti raudonųjų dobilų terapinį potencialą.
Tyrimo metodai. Bendrasis flavonoidų kiekis raudonųjų dobilų žolėje nustatytas UV spektrofotometrijos metodu. Raudonųjų dobilų veikliųjų medžiagų ADME savybių prognozė atlikta panaudojant ACD/ADME suite 5.0 programą. Statistinė analizė atlikta naudojant „Microsoft Office Excel 2003“ programą. Apskaičiuotas aritmetinis vidurkis ir standartinis nuokrypis.
Tyrimo rezultatai. Daugiausia flavonoidų raudonųjų dobilų žaliavoje yra birželio mėn. pradžioje ir viduryje (0,46 ± 0,07 proc.). Liepos mėn. pradžioje flavonoidų kiekis sumažėja 2–3 kartus, o vasaros viduryje padidėja iki 0,33 ± 0,05 proc. Rugpjūčio mėnesį flavonoidų kiekis žaliavoje vėl sumažėja iki 0,29 ± 0,03 proc. Remiantis programos prognozėmis raudonųjų dobilų žolės veikliosios medžiagos pasižymi gana palankiomis ADME savybėmis, kurios leistų šio augalo preparatus vartoti per os. Dauguma veikliųjų junginių, ypač flavonoidų aglikonai ir kumarinai turėtų labai gerai absorbuotis pasyviosios absorbcijos būdu, o didžiausias bioprieinamumas per os (> 70 proc.) prognozuojamas biochaninui A, daidzeinui, formononetinui ir kumestroliui. Beveik visoms veikliosioms medžiagoms, kaip ir statinams, prognozuojamas nedidelis pasiskirstymo tūris: nuo 0,7 l/kg iki 1,6 kg/l. Visiems junginiams prognozuojamos labai mažos tikimybės, kad jie... [toliau žr. visą tekstą]Objectives – to overview the possibility to use plants with antilipidemic properties growing in Lithuania to reduce cholesterol in blood and to substantiate therapeutic potential of the red clover. Methods. Total flavonoid amount in red clover was determined by using UV spectroscopy. ADME properties of red clover active substances were predicted by using ACD/ADME suite 5.0 software. Statistical analysis was carried out using “Microsoft Office Excel 2003” software. Arithmetical average and standard deviation were calculated. Results. The biggest amount of flavonoids in red clover raw material is detected in the beginning and middle of June (0.46 ± 0.07 %). The content of flavonoids decreases two-three times in the beginning of July, and increases to 0.33 ± 0.05 % in the middle of the summer. The flavonoid content of raw material decreases to 0.29 ± 0.03 % again in August. Based on program predictions the active substances present in the herb of red clover have beneficial ADME properties affording the preparations of this herb to use per os. Majority of active substances, especially flavonoid aglycones and coumarins should have very good absorption by passive route of absorption, and the highes oral bioavailability (>70 %) is predicted for biochanin A, daidzein, formononetin and coumestrol. Almost all active compounds, the same as statins, were predited to have low volume of distribution: from 0.7 l/kg to 1.6 l/kg. All compounds were prognosed not to be strong inhibitors of CYP... [to full text]
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AGUIAR, F. H. O. "O efeito da memória sobre a percepção de atributos ausentes/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2016. https://doi.org/10.31414/ADM.2016.T.127988.
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Shih, Chih Hsun. "O efeito das capacidades dinâmicas na relação entre a diversificação relacionada e o desempenho/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2018. https://doi.org/10.31414/ADM.2018.D.130159.
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Roble, G. L. de E. "Responsabilidade social:um estudo comparativo entre teoria e prática em múltiplos casos do setor bancário brasileiro/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2018. https://doi.org/10.31414/ADM.2018.T.130160.
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Chammas, C. B. "Comparação entre o efeito da liderança transformacional e da liderança instrumental sobre o desempenho individual do liderado e sobre a performance financeira de startups/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2018. https://doi.org/10.31414/ADM.2018.D.130161.
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Zeng, Shangzhi. "Algorithm-tailored error bound conditions and the linear convergence rae of ADMM." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/474.
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In the literature, error bound conditions have been widely used for studying the linear convergence rates of various first-order algorithms and the majority of literature focuses on how to sufficiently ensure these error bound conditions, usually posing more assumptions on the model under discussion. In this thesis, we focus on the alternating direction method of multipliers (ADMM), and show that the known error bound conditions for studying ADMM's linear convergence, can indeed be further weakened if the error bound is studied over the specific iterative sequence generated by ADMM. A so-called partial error bound condition, which is tailored for the specific ADMM's iterative scheme and weaker than known error bound conditions in the literature, is thus proposed to derive the linear convergence of ADMM. We further show that this partial error bound condition theoretically justifies the difference if the two primal variables are updated in different orders in implementing ADMM, which had been empirically observed in the literature yet no theory is known so far.
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Franchin, Taísa Busaranho. "Estudo de ADME de compostos derivados do ácido pirazinóico com atividade antimicobacteriana /." Araraquara, 2019. http://hdl.handle.net/11449/181126.
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Orientador: Rosangela Goncalves PeccininiResumo: A tuberculose é uma doença infectocontagiosa provocada pelo Mycobacterium tuberculosis que apesar de reconhecida a muitos anos, ainda tem ocorrência frequente na sociedade, assim como os casos de resistência aos medicamentos, que tem apresentado aumento significativo nos últimos anos. Na busca de novas estratégias para o tratamento, pesquisadores da Unifesp-Diadema desenvolveram novos compostos com potencial atividade antimicobacteriana, denominados pirazinoato de metila (I), pirazinoato de etila (II), pirazinoato de butila (III) e 2-(pirazina-2-carboniloxi)etill pirazina-2-carboxilato (IV), derivados do ácido pirazinóico, principal metabólito da pirazinamida. Ensaios in vitro como a avalição de propriedades físico-químicas e ensaios que avaliam a absorção, distribuição, metabolismo e excreção (ADME), auxiliam na predição das características farmacocinéticas em um estágio inicial do desenvolvimento, permitindo a seleção dos melhores candidatos a novos fármacos. O presente estudo teve como objetivo a realização de screening físico-químico (determinação do coeficiente de partição e da estabilidade química nos pHs de 1,2; 7,4 e 8,8) e ensaios de ADME (cálculo da permeabilidade aparente em monocamada de células Caco-2, a avaliação da estabilidade metabólica em microssoma de ratos e de humanos e avaliação da estabilidade em plasma de rato). Os compostos apresentaram logP de valor negativo, indicando hidrofilicidade e foi observada estabilidade frente os três pHs avaliados. A perme... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis which, although recognized for many years, still occurs frequently in society, as well as cases of drug resistance, which has shown a significant increase in recent years. In the search for new treatment strategies, researchers at Unifesp-Diadema have developed new compounds with potential antimycobacterial activity called methyl pyrazinoate (I), ethyl pyrazinoate (II), butyl pyrazinoate (III) and 2- (pyrazine-2 -carbonyloxy) ethyl] pyrazine-2-carboxylate (IV), derivatives of pyrazinoic acid, pyrazinamide's main metabolite. In vitro assays such as the evaluation of physicochemical properties and assays that evaluate absorption, distribution, metabolism and excretion (ADME), aid in the prediction of pharmacokinetic characteristics at an early stage of development, allowing the selection of the best candidates for new drugs. The objective of the present study was the physical-chemical screening (determination of partition coefficient and chemical stability at pHs of 1.2, 7.4 and 8.8) and ADME tests (calculation of the apparent permeability in monolayer of Caco-2 cells, evaluation of metabolic stability in rat and human microsomes and evaluation of stability in rat plasma). The compounds presented logP negative value, indicating hydrophilicity and stability was observed the three pHs evaluated. The apparent permeability calculated for compounds I, II, III and IV resulted in values of 4.66 x10-6; 4.14 x10-... (Complete abstract click electronic access below)
Mestre
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Dowsett, Laura Bethany. "The role of the NOS-ADMA-DDAH1 pathway in adipocytes and obesity." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24709.
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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS) which is metabolised by two isoforms of the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Inhibition of DDAH has been shown to increase ADMA concentrations both in vitro and in vivo. Clinically, high concentrations of ADMA have been associated with a range of diseases, particularly cardiovascular disease and more recently obesity. The role of the NO-ADMA-DDAH pathway has not yet been studied in adipose tissue. This thesis sets out to investigate the effects of pathological ADMA exposure firstly on adipocytes in vitro and secondly, on whole adipose physiology in vivo. In vitro the existence of the NO-ADMA-DDAH pathway was established in the 3T3-L1 cell line before investigating the effect of chronic ADMA exposure of their biology. ADMA was found to cause adipocyte hypertrophy through mTOR signalling in an NO independent manner. The effect of elevated ADMA on adipocytes in vivo was investigated through an adipocyte specific DDAH1 knockout. These mice developed visceral obesity with adipocyte hypertrophy with an increase in mTOR signalling. On a high fat diet there is a large increase in intracellular adipocyte ADMA in both knockout and control mice. Adipose vasculature is an important regulator of adipose expansion; to investigate the role of ADMA in this process an endothelial specific DDAH1 knockout mouse was developed. Angiogenesis in these mice is reduced restricting adipose growth in obesity. This thesis establishes that the NO-ADMA-DDAH1 pathway to be important in adipose physiology. Elevated ADMA in adipocytes and endothelial cells is detrimental to their function and increases various factors associated with the metabolic syndrome.
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Lanevskij, Kiril. "Vaistinių junginių absorbcija ir pasiskirstymas audiniuose: kiekybinio struktūros ir aktyvumo ryšio analizė." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114225-03220.
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Šiame darbe pristatomi mechanistiniai kiekybinio struktūros ir aktyvumo ryšio modeliai, skirti vaistinių junginių savybių, charakterizuojančių jų absorbciją ir pasiskirstymą organizme prognozavimui. Nagrinėjama keletas parametrų, apibūdinančių paprastos difuzijos per biologines membranas greitį, taip pat termodinaminės konstantos, aprašančios vaistų pasiskirstymą tarp kraujo plazmos ir audinių. Ląstelinių pernašos barjerų pralaidumas buvo modeliuojamas netiesinėmis lygtimis, siejančiomis paprastos difuzijos greitį su vaistų fizikocheminėmis savybėmis, tokiomis kaip lipofiliškumas, jonizacija, vandenilinių ryšių sudarymo potencialas ir molekulių dydis. Nustatyta, kad smegenų endotelyje ir žarnyno epitelyje stebima panašaus pobūdžio difuzijos greičio priklausomybė nuo jonizacijos – katijonai ir anijonai difunduoja atitinkamai 2 ir 3 eilėmis lėčiau už neutralias molekules. Pademonstruota, kad analizuojant vaistų pasiskirstymo tarp audinių ir kraujo duomenis, būtina paversti pradines eksperimentines vertes kitais dydžiais, atspindinčiais vaistų jungimosi prie plazmos ir audinių komponentų stiprumą. Vaistų giminingumas audiniams gali būti aprašytas jų lipofiliškumu, o neigiama jonizacijos įtaka stebima tik rūgštiniams junginiams. Taip pat parodyta, kad vaistų pernašos per hematoencefalinę užtvarą kiekybinių parametrų tiesinė kombinacija leidžia 94% tikslumu klasifikuoti vaistus pagal jų prieinamumą centrinei nervų sistemai.The objective of this work was to develop mechanistic quantitative structure activity relationship models that would facilitate the assessment of drug properties related to their absorption and distribution in the body. The analysis involved several parameters reflecting the rate of passive diffusion across brain endothelium and intestinal epithelium, and thermodynamic constants related to drug distribution between plasma and tissues. Permeation through cellular transport barriers was modeled by nonlinear equations relating the passive diffusion rate to physicochemical properties of drugs: lipophilicity, ionization, hydrogen bonding potential and molecular size. It was demonstrated that brain endothelium and intestinal epithelium exhibit a quantitatively similar pattern of permeability-ionization dependence – ionized species permeate 2-3 orders of magnitude slower than neutral molecules. Analysis of tissue to plasma partitioning data revealed the necessity to split original experimental values into separate terms reflecting plasma and tissue binding strength. Drugs’ affinity to tissues could then be described by their lipophilicity, whereas detrimental effect of ionization was only observed for acidic drugs. Finally, it was shown that a linear combination of quantitative blood-brain barrier transport parameters allows classifying drugs according to their access to central nervous system with 94% overall accuracy.
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Lanevskij, Kiril. "Absorption and Tissue Distribution of Drug-Like Compounds: Quantitative Structure-Activity Relationship Analysis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114235-89858.
Full textAbstract:
The objective of this work was to develop mechanistic quantitative structure activity relationship models that would facilitate the assessment of drug properties related to their absorption and distribution in the body. The analysis involved several parameters reflecting the rate of passive diffusion across brain endothelium and intestinal epithelium, and thermodynamic constants related to drug distribution between plasma and tissues. Permeation through cellular transport barriers was modeled by nonlinear equations relating the passive diffusion rate to physicochemical properties of drugs: lipophilicity, ionization, hydrogen bonding potential and molecular size. It was demonstrated that brain endothelium and intestinal epithelium exhibit a quantitatively similar pattern of permeability-ionization dependence – ionized species permeate 2-3 orders of magnitude slower than neutral molecules. Analysis of tissue to plasma partitioning data revealed the necessity to split original experimental values into separate terms reflecting plasma and tissue binding strength. Drugs’ affinity to tissues could then be described by their lipophilicity, whereas detrimental effect of ionization was only observed for acidic drugs. Finally, it was shown that a linear combination of quantitative blood-brain barrier transport parameters allows classifying drugs according to their access to central nervous system with 94% overall accuracy.Šiame darbe pristatomi mechanistiniai kiekybinio struktūros ir aktyvumo ryšio modeliai, skirti vaistinių junginių savybių, charakterizuojančių jų absorbciją ir pasiskirstymą organizme prognozavimui. Nagrinėjama keletas parametrų, apibūdinančių paprastos difuzijos per biologines membranas greitį, taip pat termodinaminės konstantos, aprašančios vaistų pasiskirstymą tarp kraujo plazmos ir audinių. Ląstelinių pernašos barjerų pralaidumas buvo modeliuojamas netiesinėmis lygtimis, siejančiomis paprastos difuzijos greitį su vaistų fizikocheminėmis savybėmis, tokiomis kaip lipofiliškumas, jonizacija, vandenilinių ryšių sudarymo potencialas ir molekulių dydis. Nustatyta, kad smegenų endotelyje ir žarnyno epitelyje stebima panašaus pobūdžio difuzijos greičio priklausomybė nuo jonizacijos – katijonai ir anijonai difunduoja atitinkamai 2 ir 3 eilėmis lėčiau už neutralias molekules. Pademonstruota, kad analizuojant vaistų pasiskirstymo tarp audinių ir kraujo duomenis, būtina paversti pradines eksperimentines vertes kitais dydžiais, atspindinčiais vaistų jungimosi prie plazmos ir audinių komponentų stiprumą. Vaistų giminingumas audiniams gali būti aprašytas jų lipofiliškumu, o neigiama jonizacijos įtaka stebima tik rūgštiniams junginiams. Taip pat parodyta, kad vaistų pernašos per hematoencefalinę užtvarą kiekybinių parametrų tiesinė kombinacija leidžia 94% tikslumu klasifikuoti vaistus pagal jų prieinamumą centrinei nervų sistemai.
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Li, Shijian. "Scalable User Assignment in Power Grids: A Data Driven Approach." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/1107.
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"The fast pace of global urbanization is drastically changing the population distributions over the world, which leads to significant changes in geographical population densities. Such changes in turn alter the underlying geographical power demand over time, and drive power substations to become over-supplied (demand ≪ capacity) or under-supplied (demand ≈ capacity). In this work, we make the first attempt to investigate the problem of power substation/user assignment by analyzing large scale power grid data. We develop a Scalable Power User Assignment (SPUA) framework, that takes large-scale spatial power user/substation distribution data and temporal user power consumption data as input, and assigns users to substations, in a manner that minimizes the maximum substation utilization among all substations. To evaluate the performance of SPUA framework, we conduct evaluations on real power consumption data and user/substation location data collected from Xinjiang Province in China for 35 days in 2015. The evaluation results demonstrate that our SPUA framework can achieve a 20%–65% reduction on the maximum substation utilization, and 2 to 3.7 times reduction on total transmission loss over other baseline methods."
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HERVE, FRANCOISE. "Pathologie du sein : contribution a l'elaboration du systeme adm." Rennes 1, 1992. http://www.theses.fr/1992REN1M020.
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LE, DOARE KOENIG ANNE-MARIE. "Medicaments et allaitement : contribution a l'etablissement du systeme adm." Rennes 1, 1992. http://www.theses.fr/1992REN1M095.
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Bacchi, Reggiani Giacomo. "Analisi e riorganizzazione dei processi aziendali e dei flussi: il caso ADS2 Limited." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
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Questo lavoro di tesi descrive l'esperienza di tirocinio svolta a completamento del percorso degli studi magistrali nella facoltà di Ingegneria Gestionale presso l’università di Bologna – Alma Mater Studiorum. Esso descrive l’esperienza realizzata tra febbraio e giugno 2019 presso l’azienda ADS2 Limited situata a Biggleswade, in Inghilterra.
Le finalità di questo lavoro sono quelle di analizzare e descrivere un caso di riorganizzazione dei processi e dei sistemi avvenuto all’interno di ADS2 Limited.
Nel primo capitolo viene presentata l’azienda, il contesto societario, la sua struttura interna, le risorse di cui dispone e le motivazioni alla base di questa riorganizzazione. Successivamente vengono esposti gli obiettivi perseguiti dall’azienda e quelli del tirocinio.
Nel secondo è illustrato il business realizzato, il modello teorico che inquadra le logiche industriali di ADS2 Limited. È stato preso come riferimento il modello di Wortmann e illustrato la posizione dell'azienda all’interno dello stesso. Vengono poi presentate le problematiche riscontrate all’avvio. Esse sono fondamentali per intrepretare al meglio il percorso fatto dall’azienda durante l’esperienza di tirocinio.
Nel terzo capitolo si descrive lo strumento che l’azienda ha deciso di adottare per sostenere il processo di trasformazione iniziato. Successivamente sono esaminati nel dettaglio tutti gli interventi migliorativi realizzati e il ruolo che il nuovo strumento ha ricoperto in questi.
Nel quarto capitolo viene analizzato in modo particolare uno di questi, ossia la riorganizzazione dell’area del magazzino.
Nel quinto capitolo invece sono presentati alcuni dati che descrivono gli effetti registrati a seguito degli interventi attuati. Vengono poi fatte delle considerazioni in merito ai risultati e agli obiettivi che erano stati posti all’inizio.
Infine, viene fatta un’analisi sull’esperienza nel suo complesso cercando di evidenziare gli aspetti positivi che hanno contraddistinto questo tirocinio.
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Annergren, Mariette. "ADMM for l1 Regularized Optimization Problems and Applications Oriented Input Design for MPC." Licentiate thesis, KTH, Reglerteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103618.
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This licentiate thesis is divided into two main parts. The first part considers alternating direction method of multipliers (ADMM) for ℓ1 regularized optimization problems and the second part considers applications oriented input design for model predictive control (MPC). Many important problems in science and engineering can be formulated as convex optimization problems. As such, they have a unique solution and there exist very efficient algorithms for finding the solution. We are interested in methods that can handle big, in terms of the number of variables, optimization problems in an efficient way. Large optimization problems are common in many fields of research, for example, the problem of feature selection from huge medical data sets. ADMM is a method capable of handling such problems. We derive a scalable and efficient algorithm based on ADMM for two ℓ1 regularized optimization problems: ℓ1 mean and covariance filtering that occur in signal processing, and ℓ1 regularized MPC that is a specific type of model based control. System identification provides tools for estimating models of dynamical systems from experimental data. The application of such models can be divided into three main categories: prediction, simulation and control. We focus on identifying models used for control, with special attention to MPC. The objective is to minimize a cost related to the identification experiment while guaranteeing, with high probability, that the obtained model gives an acceptable control performance. We use applications oriented input design to find such a model. We present a general procedure of implementing applications oriented input design to unknown, and possibly nonlinear, systems controlled using MPC. In addition, we show that the input design problem obtained for output-error systems has the same simple structure as for finite impulse response systems.QC 20121017
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Blackwell, Scott. "The measurement, biological variation and response to acute inflammation of asymmetric dimethylarginine (ADMA)." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4912/.
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Introduction and methods Asymmetric dimethylarginine (ADMA) is a potent endogenous competitive inhibitor of nitric oxide synthases, which has attracted considerable attention as a marker and mediator of atherosclerotic disease and as a potential mediator of multiple organ failure in critical illness due to endothelial dysfunction. However, data regarding basic aspects of its biology such as biological variation and its response to acute inflammation are lacking. Moreover, significant methodological variability has been a barrier to collating the burgeoning data available. Therefore, this thesis describes the development and validation of a reliable assay for measurement of ADMA and related compounds in plasma, urine and other biological fluids based on isocratic reverse phase high performance liquid chromatography (HPLC). This method was used to determine the biological variation of ADMA in human plasma, and its response to acute inflammation using a model of elective knee arthroplasty. Further HPLC methods for measurement of dimethylamine (DMA), the main metabolite of ADMA, and nitrate were developed and used to determine excretion of these compounds in acute inflammation to complement the observed changes in plasma ADMA concentration. Results Complete chromatographic separation of arginine, homoarginine, monomethyl-arginine, ADMA and its structural isomer SDMA was achieved, permitting their accurate quantification using a novel, non-endogenous, internal standard. The intra-individual biological variation of ADMA was found to be low at 7.4%, imposing a tight imprecision goal for analytical methods. Plasma ADMA concentration decreases rapidly during the acute inflammatory response, with a median decrease of around 30%, and a significant change already evident as little as 12 hours following the onset of inflammation. No similar change was seen in the concentration of the closely related compound SDMA. No significant increase in the urine excretion of DMA was noted during the early phase of the response, with a significant increase seen 5 days following the insult by which point the plasma ADMA concentration had returned to baseline levels. A small, but significant, decrease in nitrate excretion during the inflammatory response was seen, mirroring the observed changes in plasma ADMA. Conclusion The low biological variation of ADMA suggests physiological regulation. The rapid and significant decrease in plasma concentration during inflammation does not appear due to increased catabolism, but rather is more likely to represent increased cellular partitioning. This may be associated with an impairment in NOS activity. It is unclear whether this is of pathological significance, or represents a physiological response to regulate NO production in inflammation. Further study is warranted in relevant models, particularly with attention to intracellular concentrations.
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Piechota, Przemyslaw. "Development of in silico models for the prediction of toxicity incorporating ADME information." Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4554/.
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Drug discovery is a process that requires a significant investment in both time and resources. Although recent developments have reduced the number of drugs failing at the later stages of development due to poor pharmacokinetic and/or toxicokinetic profiles, late stage attrition of drug candidates remains a problem. Additionally, there is a need to reduce animal testing for toxicological risk assessment for ethical and financial reasons. In silico methods offer an alternative that can address these challenges. A variety of computational approaches have been developed in the last two decades, these must be evaluated to ensure confidence in their use. The research presented in this thesis has assessed a range of existing tools for the prediction of toxicity and absorption, distribution, metabolism and elimination (ADME) parameters with an emphasis on absorption and xenobiotic metabolism. These two ADME properties largely determine bioavailability of a drug and, in turn, also influence toxicity. In vitro (Caco-2 cells and the parallel artificial membrane permeation assay) and in silico approaches, such as various druglikeness filters, can be used to estimate human intestinal absorption; a comparison between different methods was performed to identify relative strengths and weaknesses of the approaches. In terms of xenobiotic metabolism it is not only important to predict metabolites correctly, but it is also crucial to identify those compounds that can be biotransformed into species that can covalently bind to biomolecules. Structural alerts are routinely used to screen for such potential reactive metabolites. The balance between sensitivity and specificity of such reactive metabolite alerts has been discussed in the context of correctly predicting reactive metabolites of pharmaceuticals (using data available from DrugBank). Off-target toxicity, exemplified by human Ether-à-go-go-Related Gene (hERG) channel inhibition, was also explored. A number of novel structural alerts for hERG toxicity were developed based on groups of structurally similar compounds. Finally, the importance of predicting potential ecotoxicological effects of drugs was also considered. The utility of zebrafish embryos to distinguish between baseline and excess toxicity was investigated. In evaluating this selection of existing tools, improvements to the methods have been proposed where possible.
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Bareha, Younès. "Modélisation des processus de transformation de l'azote en digestion anaérobie : application à l'optimisation de la valorisation des digestats." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B067/document.
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La valorisation des déchets par digestion anaérobie conduit à la production d’un résidu, appelé digestat, qui est composé de la matière organique non biodégradée et présente une forte teneur en azote ammoniacal et organique. De par cette richesse en azote, les digestats présentent un intérêt grandissant pour la substitution aux engrais minéraux. L’objectif de cette thèse est de comprendre les transformations de l’azote en digestion anaérobie afin de prédire la qualité azotée des digestats. Cette compréhension des processus de transformation de l’azote ouvrira la possibilité de dimensionner et piloter le procédé de digestion anaérobie pour une substitution optimisée des engrais minéraux par les digestats. Pour cela, deux approches ont été développées: (i) une approche compréhensive centrée sur la compréhension de la bioaccessibilité de l’azote organique en lien avec sa biodégradabilité, et la compréhension des transformations de l’azote en digestion anaérobie en conditions de laboratoire et pilote; et ; (ii) une approche numérique où les processus identifiés ont été intégrés à des outils de modélisation à bases statistiques et biocinétiques permettant de prédire les propriétés azotées des digestats en fonction des cocktails de substrats et du temps de séjour dans le digesteurEnergetic recovery of waste by anaerobic digestion leads to the production of a residue called digestate, which is composed of non-biodegraded organic matter and has a high content of ammoniacal and organic nitrogen. Due to this high nitrogen content, digestates are growing interest for the substitution of mineral fertilizers. The objective of this thesis is to understand the transformations of nitrogen that occur during anaerobic digestion in order to predict the nitrogen quality of digestates. This understanding of nitrogen transformation processes will allows the design and management of anaerobic digestion plants aiming at the optimization of the substitution of mineral fertilizers by digestates. To this end, two approaches were used in this work: (i) an experiment approach focused on the understanding of the bioaccessibility of organic nitrogen in relation to its biodegradability, and the understanding of the transformations of nitrogen in anaerobic digestion under laboratory and pilot conditions; and; (ii) a numerical approach where previously developed knowledge has been integrated in statistical and biokinetic modeling tools to predict the nitrogen properties of digestates according to substrate cocktails and residence time in the digester
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Moda, Tiago Luiz. "Desenvolvimento de modelos in silico de propriedades de ADME para a triagem de novos candidatos a fármacos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22032007-112055/.
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As ferramentas de modelagem molecular e de estudos das relações quantitativas entre a estrutura e atividade (QSAR) ou estrutura e propriedade (QSPR) estão integradas ao processo de planejamento de fármacos, sendo de extremo valor na busca por novas moléculas bioativas com propriedades farmacocinéticas e farmacodinâmicas otimizadas. O trabalho em Química Medicinal realizado nesta dissertação de mestrado teve como objetivo estudar as relações quantitativas entre a estrutura e as propriedades farmacocinéticas biodisponibilidade oral e ligação às proteínas plasmáticas. Para a realização deste trabalho, conjuntos padrões de dados foram organizados para as propriedades biodisponibilidade e ligação às proteínas plasmáticas contendo a informação qualificada sobre a estrutura química e a propriedade alvo correspondente. Os conjuntos de dados criados formaram as bases científicas para o desenvolvimento dos modelos preditivos empregando os métodos holograma QSAR e VolSurf. Os modelos finais de HQSAR e VolSurf gerados neste trabalho possuem elevada consistência interna e externa, apresentando bom poder de correlação e predição das propriedades alvo. Devido à simplicidade, robustez e consistência, estes modelos são guias úteis em Química Medicinal nos estágios iniciais do processo de descoberta e desenvolvimento de fármacos.Molecular modeling tools and quantitative structure-activity relantionships (QSAR) or structure-property (QSPR) are integrated into the drug design process in the search for new bioactive molecules with good pharmacokinetic and pharmacodynamic properties. The Medicinal Chemistry work carried out in this Masters dissertation concerned studies of the quantitative relationshisps between chemical structure and the pharmacokinetic properties oral bioavailability and plasma protein binding. In the present work, standard data sets for bioavailability and plasma protein binding were organized encompassing the structural information and corresponding pharmacokinetic data. The created data sets established the scientific basis for the development of predictive models using the hologram QSAR and VolSurf methods. The final HQSAR and VolSurf models posses high internal and external consistency with good correlative and predictive power. Due to the simplicity, robustness and effectivess, these models are useful guides in Medicinal Chemistry in the early stages of the drug discovery and development process.
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Gardell, Fredrik. "Holography of SYK model." Thesis, Uppsala universitet, Teoretisk fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-365188.
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The aim of the thesis is to study the AdS/CFT correspondence and the AdS2/SYK connection as a very special example of the duality. While the first part of the thesis contains a review of AdS/CFT correspondence in arbitrary dimensions, the later parts focus on an interesting and speculative connection between the gravitational physics in two dimensional nearly AdS2 spacetime and one dimensional SYK model. More specifically, the connection is realized in terms of certain features of the SYK model in strong coupling limit, which resembles those of nearly AdS2 Jackiw-Teitelboim theory.
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Chen, Chi-Yuan. "Ab Initio Molecular Dynamics Simulation of Proton Transfer in Imidazole: An Atom-Centered Density Matrix Propagation (ADMP) Approach." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1141281810.
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Thesis (M.S.)--University of Cincinnati, 2006.Title from electronic thesis title page (viewed Apr. 24, 2006). Includes abstract. Keywords: ADMP, proton, ONIOM, imidazole. Includes bibliographical references.
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BOCHET, FLORENCE. "Pathologie des glandes salivaires : contribution a l'etablissement du systeme adm." Rennes 1, 1992. http://www.theses.fr/1992REN1M108.
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SOUZA, S. P. "Poder, saber e subjetividades: constituição e formação do sujeito ADM." Universidade Federal do Espírito Santo, 2011. http://repositorio.ufes.br/handle/10/2141.
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Previous issue date: 2011-11-28O estudo analisa a constituição e a formação dos sujeitos adm. Os materiais e a análise foram organizados em torno de três eixos: eixo das subjetividades, eixo dos poderes e eixo dos saberes. A seleção dos materiais, o modo de construir a análise e o texto, assim como os conceitos usados para pensar a formação em administração, foram possíveis a partir dos estudos de Michel Foucault sobre os códigos que regulam modos de se conduzir e sobre a produção de verdades que servem como justificativa. Os eixos são produções teórico-empíricas, pois neles estão as análises das entrevistas e as teorias, além das análises da formação em administração que ocorriam a partir de documentos, legislação e elementos históricos. As entrevistas, realizadas com professores que lecionam no curso de administração, alunos em vias de formação e administradores recém-egressos, serviram como disparadores das análises. Não se pretendeu produzir uma nova verdade sobre a formação em administração, mas, sim, mapear as condições de emergência dos sujeitos adm e de sua formação. Dentre as condições mapeadas estão os modos pelos quais somos governados, ou seja, os modelos de conduta que estão pautados nos modos de ação empresariais, a profissionalização, a sistematização do ensino e a constituição de um campo de conhecimento. Em suma, a pesquisa deparou-se com um processo de formação, via ensino superior, que pode levar tanto à reprodução de formas predominantes quanto à produção de rupturas com tais formas
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Casadio, Alessandro. "Analisi delle linee di produzione e miglioramento dei processi aziendali: il caso ADS2 LTD." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
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Tirocinio di sei mesi svolto in una delle sedi inglesi del gruppo Celli, leader nel mondo del beverage industry. Dopo una riorganizzazione strutturale e una serie di acquisizioni nasceva la necessità di riorganizzare tutti i processi interni ed esterni al sito. Allo stesso momento si registrava la scelta di gruppo di implementare un nuovo sistema gestionale Dynamics 365. Il mio ruolo ha avuto il compito di rianalizzare tutte le linee di produzioni presenti al fine di controllare e estendere la base dati presente già presente sul sistema e di proseguire il lavoro di registrazione delle informazioni a supporto della pianificazione della produzione, con l'obiettivo ultimo di ottenere una base dati che permettesse di far girare l'MPR e generare di rimando informazioni più precise e realistiche. Con i dati ricavati nei primi mesi poi, nell'ultima parte del periodo ci si è dedicati a piccoli progetti di miglioramento sempre in orbita delle attività di produzione. In particolare si riportano le attività svolte per migliorare la registrazione dei materiali utilizzati e degli scarti da produzione, attività svolte finalizzate a migliorare l'efficienza nello specifico nelle attività di impacchettamento dei prodotti e, l'ultimo, una piccola analisi e determinazione degli standard di qualità per una specifica linea produttiva rivelatasi particolarmente critica nei mesi.
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Szoltys, Kryštof. "Parametrické CAD systémy a databáze součástí." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217957.
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Autodesk Inventor is a full 3D CAD system. This system includes tools for working environment tool, component design tool including information data management and technical support. The target of the first part is to describe the most important new features brought by Autodesk Inventoru 2009 version. In of next chapters the work describes creation common iPart, which is basically different variants set (proportions, material …) of one entity, and preparation before correct publication to the content center, which is a virtual database of all iPart. Also there is presented how to create the content center, how to work with it and adjust data. The aim of work is then the creation database a stator and a rotor packet for the firm ATAS electromotor Náchod Inc. In the thesis there is described creation of the lamination as an iPart and their publication to the new content center.
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CLERET, MIREILLE. "Apports des techniques informatiques en medecine : un exemple de systeme d'aide au diagnostic medical a partir de la base de connaissances adm." Rennes 1, 1994. http://www.theses.fr/1994REN1M064.
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GUERY, OLIVIER. "Evaluation de la base de connaissances adm a partir de donnees cliniques tirees de la litterature." Rennes 1, 1994. http://www.theses.fr/1994REN1M037.
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Povey, Adam Charles. "The application of optimal estimation retrieval to lidar observations." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:eb94de02-ad92-4eeb-b15c-094b05fa11c6.
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Optimal estimation retrieval is a nonlinear regression scheme to determine the conditions statistically most-likely to produce a given measurement, weighted against any a priori knowledge. The technique is applied to three problems within the field of lidar data analysis. A retrieval of the aerosol backscatter and either the extinction or lidar ratio from two-channel Raman lidar data is developed using the lidar equations as a forward model. It produces profiles consistent with existing techniques at a resolution of 10-1000 m and uncertainty of 5-20%, dependent on the quality of data. It is effective even when applied to noisy, daytime data but performs poorly in the presence of cloud. Two of the most significant sources of uncertainty in that retrieval are the nonlinearity of the detectors and the instrument's calibration (known as the dead time and overlap function). Attempts to retrieve a nonlinear correction from a pair of lidar profiles, one attenuated by a neutral density filter, are not successful as uncertainties in the forward model eliminate any information content in the measurements. The technique of Whiteman et al. [1992] is found to be the most accurate. More successful is a retrieval of the overlap function of a Raman channel using a forward model combining an idealised extinction profile and an adaptation of the equations presented in Halldórsson and Langerholc [1978]. After refinement, the retrieval is shown to be at least as accurate, and often superior to, existing methods of calibration from routine measurements, presenting uncertainties of 5-15%. These techniques are then applied to observations of ash over southern England from the Eyjafjallajökull eruption of April 2010. Lidar ratios of 50-60 sr were observed when the plume first appeared, which reduced to 20-30 sr after several days within the planetary boundary layer, indicating an alteration of the particles over time.
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Cubukgil, Evren. "Uncertainty and firm investment." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:c3fb67f9-adf2-41ac-98b9-cb2878e2b2d6.
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This thesis explores effects of uncertainty on firm investment that are described in estimates of firm level investment specifications which include proxies for uncertainty over expected future firm profitability. A panel data set of UK firms covering the period 1987-2000 is used to estimate firm level investment specifications. Within year volatility in stock returns - a common proxy for firm specific uncertainty in previous literature - is compared with covariance measures between stock returns and market returns representing un-diversifiable risk from the CAPM; and with alternative uncertainty proxies based on volatility in I/B/E/S securities analysts' forecasts of earnings per share. Within estimates of firm level investment specifications, the thesis investigates the sensitivity of coefficients on uncertainty terms to the choice of underlying investment specification: error correction model between the natural logarithms of capital and sales; or the Hayashi (1982) Q model of investment. Coefficients on stock return volatility measures of uncertainty terms are found to vary significantly between estimates of error correction and average q specifications. Differences between coefficients estimated on uncertainty terms across estimates of these two investment specifications are supported with simulated data. Uncertainty measures based on volatility in I/B/E/S securities analysts' forecasts of earnings per share are found to be much more informative of investment behaviour than within year stock return volatility in estimates of both error correction and average q specifications. Coefficients on I/B/E/S uncertainty proxies imply more consistent investment-uncertainty relationships across estimates of error correction and average q specifications for the UK panel data set.