Dissertations / Theses on the topic 'ADM2'
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Engelsoy, Julius. "Considerations Regarding AdS2 Backreaction and Holography." Thesis, KTH, Fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210245.
Full textVoronkova, Valentina Vladimirovna. "ADH2 repression : a genetic and biochemical approach /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9221.
Full textScaramuzzino, Giuseppe. "Definition and Standardization of ADS2 Ltd Manufacturing Processes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Find full textIannone, Lucio. "ADMA metabolism and chronic hypoxia-induced pulmonary hypertenstion." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24911.
Full textQueen, André Sampaio. "Simulador de reatores anaeróbios com base no ADM1." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/3/3139/tde-04092006-170243/.
Full textFirst, this work intends to show the importance of research in modeling, simulation and control of wastewater treatment processes, and to point the delay of our country (Brazil) in this subject, compared to the advance of the international initiatives. This work presents the specific problem of modeling the anaerobic digestion and proposes a new tool to simulate the steady state condition in anaerobic reactors. The simulator is based on the ADM1 (Anaerobic Digestion Model No 1), developed by IWA in 2002, and is implemented in C++. The intention is to give free access to a new simulation software with the advantages of better methodology and friendly graphical interface. This tool should be able to bring to the professionals all the sophistication of a more complete modelling in the microbiological and physical-chemical point of view. The developed methodology revealed itself to be very efficient for the attainment of the steady state condition. Consequently, it makes the characterization of the influent the critic stage of the simulation process. The developed method is so efficient that allows simulation studies to be carried out using hypothetical influents and reactors. Thus, it brings independence for simulation studies with no need of complex or unusual laboratorial analyses.
Tejkl, Jakub. "Trvanlivost destiček ADMX při frézování materiálů skupiny S." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231383.
Full textTomlinson, James. "The role of DDAH and ADMA in kidney disease." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24541.
Full textAnnergren, Mariette. "Application-Oriented Input Design and Optimization Methods Involving ADMM." Doctoral thesis, KTH, Reglerteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-187890.
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Forgey, Cady. "Prevention of Chronic Inflammation by Targeting Macrophage Integrin aDb2." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3849.
Full textAbboud, Azary. "Optimisation distribuée dans les grands systèmes interconnectés avec ADMM." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLC004/document.
Full textThis thesis focuses on the construction of distributed algorithms for optimizing resource production in a large interconnected system. In particular, it focuses on power grid and 5G cellular networks. In the case of power grid networks, we consider the OPF (Optimal Power Flow) problem in which one seeks to manage and optimize the production of electrical energy in a distributed manner. We focus on a linearized version of the problem, the DC-OPF (Direct- Current Optimal Power Flow) problem. This optimization problem is convex; the aim is to minimize the cost of energy generation while respecting the limits of the transmission line and the power flow constraints. In the case of 5G cellular networks, we formulate a caching problem. We aim to offload the backhaul link usage connecting the small bases stations (SBSs) to the central scheduler (CS). The SBSs are equipped with a limited storage capacity. We seek to find the optimal way to store files so as to reduce the cost on the use of backhaul and sharing files with other SBSs. The approach adopted in this thesis is to apply the ADMM (Alternating Direction Method of Multipliers), an optimization method that is applied iteratively, to an optimization problem that we adequately formulated previously. This problem can both describe the DC-OPF problem and the Caching problem. We prove the convergence of the method when applied node by node in a fully distributed manner. Additionally, we prove its convergence in the case where the network is divided into multiple areas or nations that may or may not overlap. Furthermore, in the context of a network with multiple areas, we show that the application of ADMM in a random manner by a single randomly chosen area also converges to the optimal solution of the problem
Carrigan, Matthew A. "The reason we drink alcohol is rooted in our evolution." Revista de Química, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/99743.
Full textWe have resurrected ancient enzymes from our primate ancestors and identified several mutations occurring approximately 10 million years ago that endowed our ancestors with an enhanced capacity to metabolize ethanol. This episode of enzyme evolution coincided with a global climate change associated with shrinking African forests and our ancestor’s transition from an arboreal lifestyle to a terrestrial lifestyle where highly fermented fruit is more common. These studies suggest that the evolution of our ancestor’s enzymes may have enabled our ancestors to exploit an alternative source of nourishment during a time when food was scarce.
Bagli, Maria Chiara. "ll metodo ADMM per la regolarizzazione con Variazione Totale Generalizzata." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20966/.
Full textPiolanti, Simone. "Il formalismo ADM per la metrica FLRW." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Find full textWronka, Gerd. "Die Integration adenoviraler DNA in das Genom der Wirtszelle Untersuchung der Verknüpfungsstellen zwischen adenoviraler DNA und Säuger-DNA in einem zellfreien System zur integrativen Rekombination und genomische Lokalisierung von adenoviralen Sequenzen in Ad2- und Ad12-transformierten Zellinien /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965016331.
Full textjaafar, hussein amez. "AGING AND DECISION MAKING AS MEASURED BY THE SWEDISH VERSION OF THE ADMC BATTERY." Thesis, Umeå universitet, Institutionen för psykologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68356.
Full textBetula Project
Hasan, Abdallah Khalil Abdallah. "The role of educational leadership in providing quality culture at ADMC." Thesis, University of Lincoln, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400804.
Full textNguyen, Hoa Huu. "Modelling of food waste digestion using ADM1 integrated with Aspen Plus." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/375082/.
Full textSilva, Flávio Gonzaga Castro Santos. "Modelização dinâmica do processo de digestão anaeróbia utilizando o modelo ADM1." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/548.
Full textO presente trabalho propõe a aplicação de um modelo dinâmico para descrever o processo de tratamento anaeróbio, baseado no modelo ADM1. O estudo de modelização compreendeu a designação de variáveis implicadas no processo biológico, a implementação computacional, em duas plataformas informáticas distintas, das equações cinéticas que o descrevem e ainda a verificação do seu desempenho através de simulações para diferentes cenários, entre os quais um ensaio laboratorial semi-contínuo estudando a degradação anaeróbia de um efluente específico gerado numa indústria de pasta de papel pelo processo ao sulfito. Uma análise de incerteza efectuada ao modelo permitiu identificar os parâmetros que mais influenciam o comportamento das variáveis simuladas: a taxa máxima de degradação de acetato (km_ac), o factor de conversão de acetato em biomassa (Y_ac) e a constante de semi-saturação de degradação do acetato (Ks_ac). Após uma estimação destes parâmetros, o modelo foi validado com base no ajuste das simulações a resultados experimentais resultantes da operação laboratorial de um segundo reactor anaeróbio semi-contínuo, utilizado para o estudo de uma condição alimentada distinta – a degradação anaeróbia do mesmo efluente, com adição suplementar de uma fonte de carbono externa. Conclui-se que o modelo simula relativamente bem a maioria das variáveis implicadas no processo específico de degradação – eficiência de remoção de matéria orgânica, produção de metano, etc. -, apesar destas revelarem alguma sensibilidade a alguns dos parâmetros especificados nas equações do processo anaeróbio. Em geral, nas cargas orgânicas mais elevadas, o modelo desenvolvido tende a desviar-se ligeiramente dos valores de algumas variáveis de estado, subestimando a eficiência de remoção de matéria orgânica. Será necessário proceder a uma calibração mais exacta para tornar possível a aplicação prática das simulações, recorrendo a dados reais. O esforço de modelização constitui assim uma ferramenta que pode ser utilizada na previsão do desempenho de operações de tratamento anaeróbio à escala industrial, quer em condições estacionárias, quer em condições de elevada variação de carga orgânica. Através da simulação é possível desenvolver prognósticos detalhados e estratégias de controlo de reactores anaeróbios que, de outra forma, só poderiam ser determinadas por medições experimentais dispendiosas e demoradas. ABSTRACT: This work presents the application of a dynamic model describing the anaerobic treatment process, based on ADM1 model. The modelling study consisted of setting the biological process variables, the computational implementation of its kinetic equations into two different software applications, as well as model verification by simulating it for different frameworks, one of those was the laboratorial operation of a semi-continuous assay testing the anaerobic degradation of an effluent generated in a sulphite pulp mill. An uncertainty analysis permitted the identification of the most influential parameters on the behaviour of simulated variables: maximum specific acetate uptake rate (km_ac), yield of biomass on acetate (Y_ac) and half-saturation constant for acetate uptake (Ks_ac). After parameter estimation, the model was validated by means of the simulation fitting to experimental data sets from the laboratorial operation of a second semi-continuous reactor, used for studying a different feed condition – the anaerobic degradation of the same effluent using an external carbon source addition. It was concluded that the model simulates quite well some of the variables implied on the specific degradation process – organic matter removal, methane production, etc. -, although they revealed some sensitivity to a large number of parameters embedded on the anaerobic process equations. In general, in the higher organic loads, the implemented model trends to deviate slightly the values for several state variables, underestimating the organic matter removal efficiency. It is then necessary to accurately calibrate the mathematical model on existing real data in order to be possible the application of the simulation results in practice. The modelling efforts can be a valuable tool predicting the performance at fullscale treatment operations, either in steady-state conditions, or in changeable organic load conditions. Through simulation it is then possible to develop detailed prognosis and control strategies for several influent characteristics and operation conditions in the anaerobic reactors, which otherwise could only be determined by time-consuming and expensive measurement phases.
Schulze, Karen [Verfasser]. "Prognostische Bedeutung von asymmetrischem Dimethylarginin (ADMA) beim akuten Myokardinfarkt / Karen Schulze." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2011. http://d-nb.info/101391340X/34.
Full textCanault, Baptiste. "Développement d'une plateforme de prédiction in silico des propriétés ADME-Tox." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2048/document.
Full textAbsorption, Distribution, Metabolism, Elimination (ADME) and Toxicity (Tox) properties are crucial for the success of clinical trials of a drug candidate. During this process, chemoinformatics is regularly used to predict the ADME-Tox profile of bioactive compounds and to improve their pharmacokinetic properties. In silico approaches have already been developed to improve poor pharmacokinetics and toxicity of lead compounds. These predictive models, based on the quantification of structure-activity relationships (QSAR), were not always efficient enough due to the low number of accessible biological data and their heterogeneity induced by the differences in experimental assays or the significant experimental error. In this thesis, we first built a database containing 150,000 data points for about 50 ADME-Tox properties. In order to valorize all this data, we then proposed an automatic platform for creating predictive models. This platform, called MetaPredict, has been designed to optimize each step of model development, in order to improve their quality and robustness. Third,, we promoted the statistical models using the online application of MetaPredict platform. This application has been developed to facilitate the use of newly built models, to provide a simplified interpretation of the results and to modulate the obtained observations according to the needs of the researchers. Finally, this platform provides an easy access to the ADME-Tox models for the scientific community
Claros, Santiago Carlos Eduardo, Portugal Julio Raul Corcuera, Espinoza Maribel Martina Cuenca, Garaycochea Pablo Rafael Cárdenas, Aguila Peralta Irma Del, Frias Bruno Alberto Rivas, Boada Julio Cromwell Ubillús, and Fajardo Soraya Katia Yrigoyen. "Globalización: Enfoque cultural y económico (Adm.) - HU65 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/624404.
Full textBercevič, Renata. "Antilipideminėmis savybėmis pasižyminčių vaistinių augalų veikliųjų medžiagų palyginamoji apžvalga ir raudonųjų dobilų (Trifolium pratense L.) žolės pritaikymo mažinti cholesterolio kiekį kraujyje pagrindimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110628_151406-22258.
Full textObjectives – to overview the possibility to use plants with antilipidemic properties growing in Lithuania to reduce cholesterol in blood and to substantiate therapeutic potential of the red clover. Methods. Total flavonoid amount in red clover was determined by using UV spectroscopy. ADME properties of red clover active substances were predicted by using ACD/ADME suite 5.0 software. Statistical analysis was carried out using “Microsoft Office Excel 2003” software. Arithmetical average and standard deviation were calculated. Results. The biggest amount of flavonoids in red clover raw material is detected in the beginning and middle of June (0.46 ± 0.07 %). The content of flavonoids decreases two-three times in the beginning of July, and increases to 0.33 ± 0.05 % in the middle of the summer. The flavonoid content of raw material decreases to 0.29 ± 0.03 % again in August. Based on program predictions the active substances present in the herb of red clover have beneficial ADME properties affording the preparations of this herb to use per os. Majority of active substances, especially flavonoid aglycones and coumarins should have very good absorption by passive route of absorption, and the highes oral bioavailability (>70 %) is predicted for biochanin A, daidzein, formononetin and coumestrol. Almost all active compounds, the same as statins, were predited to have low volume of distribution: from 0.7 l/kg to 1.6 l/kg. All compounds were prognosed not to be strong inhibitors of CYP... [to full text]
AGUIAR, F. H. O. "O efeito da memória sobre a percepção de atributos ausentes/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2016. https://doi.org/10.31414/ADM.2016.T.127988.
Full textShih, Chih Hsun. "O efeito das capacidades dinâmicas na relação entre a diversificação relacionada e o desempenho/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2018. https://doi.org/10.31414/ADM.2018.D.130159.
Full textRoble, G. L. de E. "Responsabilidade social:um estudo comparativo entre teoria e prática em múltiplos casos do setor bancário brasileiro/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2018. https://doi.org/10.31414/ADM.2018.T.130160.
Full textChammas, C. B. "Comparação entre o efeito da liderança transformacional e da liderança instrumental sobre o desempenho individual do liderado e sobre a performance financeira de startups/." reponame:Biblioteca Digital de Teses e Dissertações da FEI, 2018. https://doi.org/10.31414/ADM.2018.D.130161.
Full textZeng, Shangzhi. "Algorithm-tailored error bound conditions and the linear convergence rae of ADMM." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/474.
Full textFranchin, Taísa Busaranho. "Estudo de ADME de compostos derivados do ácido pirazinóico com atividade antimicobacteriana /." Araraquara, 2019. http://hdl.handle.net/11449/181126.
Full textResumo: A tuberculose é uma doença infectocontagiosa provocada pelo Mycobacterium tuberculosis que apesar de reconhecida a muitos anos, ainda tem ocorrência frequente na sociedade, assim como os casos de resistência aos medicamentos, que tem apresentado aumento significativo nos últimos anos. Na busca de novas estratégias para o tratamento, pesquisadores da Unifesp-Diadema desenvolveram novos compostos com potencial atividade antimicobacteriana, denominados pirazinoato de metila (I), pirazinoato de etila (II), pirazinoato de butila (III) e 2-(pirazina-2-carboniloxi)etill pirazina-2-carboxilato (IV), derivados do ácido pirazinóico, principal metabólito da pirazinamida. Ensaios in vitro como a avalição de propriedades físico-químicas e ensaios que avaliam a absorção, distribuição, metabolismo e excreção (ADME), auxiliam na predição das características farmacocinéticas em um estágio inicial do desenvolvimento, permitindo a seleção dos melhores candidatos a novos fármacos. O presente estudo teve como objetivo a realização de screening físico-químico (determinação do coeficiente de partição e da estabilidade química nos pHs de 1,2; 7,4 e 8,8) e ensaios de ADME (cálculo da permeabilidade aparente em monocamada de células Caco-2, a avaliação da estabilidade metabólica em microssoma de ratos e de humanos e avaliação da estabilidade em plasma de rato). Os compostos apresentaram logP de valor negativo, indicando hidrofilicidade e foi observada estabilidade frente os três pHs avaliados. A perme... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis which, although recognized for many years, still occurs frequently in society, as well as cases of drug resistance, which has shown a significant increase in recent years. In the search for new treatment strategies, researchers at Unifesp-Diadema have developed new compounds with potential antimycobacterial activity called methyl pyrazinoate (I), ethyl pyrazinoate (II), butyl pyrazinoate (III) and 2- (pyrazine-2 -carbonyloxy) ethyl] pyrazine-2-carboxylate (IV), derivatives of pyrazinoic acid, pyrazinamide's main metabolite. In vitro assays such as the evaluation of physicochemical properties and assays that evaluate absorption, distribution, metabolism and excretion (ADME), aid in the prediction of pharmacokinetic characteristics at an early stage of development, allowing the selection of the best candidates for new drugs. The objective of the present study was the physical-chemical screening (determination of partition coefficient and chemical stability at pHs of 1.2, 7.4 and 8.8) and ADME tests (calculation of the apparent permeability in monolayer of Caco-2 cells, evaluation of metabolic stability in rat and human microsomes and evaluation of stability in rat plasma). The compounds presented logP negative value, indicating hydrophilicity and stability was observed the three pHs evaluated. The apparent permeability calculated for compounds I, II, III and IV resulted in values of 4.66 x10-6; 4.14 x10-... (Complete abstract click electronic access below)
Mestre
Dowsett, Laura Bethany. "The role of the NOS-ADMA-DDAH1 pathway in adipocytes and obesity." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24709.
Full textLanevskij, Kiril. "Vaistinių junginių absorbcija ir pasiskirstymas audiniuose: kiekybinio struktūros ir aktyvumo ryšio analizė." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114225-03220.
Full textThe objective of this work was to develop mechanistic quantitative structure activity relationship models that would facilitate the assessment of drug properties related to their absorption and distribution in the body. The analysis involved several parameters reflecting the rate of passive diffusion across brain endothelium and intestinal epithelium, and thermodynamic constants related to drug distribution between plasma and tissues. Permeation through cellular transport barriers was modeled by nonlinear equations relating the passive diffusion rate to physicochemical properties of drugs: lipophilicity, ionization, hydrogen bonding potential and molecular size. It was demonstrated that brain endothelium and intestinal epithelium exhibit a quantitatively similar pattern of permeability-ionization dependence – ionized species permeate 2-3 orders of magnitude slower than neutral molecules. Analysis of tissue to plasma partitioning data revealed the necessity to split original experimental values into separate terms reflecting plasma and tissue binding strength. Drugs’ affinity to tissues could then be described by their lipophilicity, whereas detrimental effect of ionization was only observed for acidic drugs. Finally, it was shown that a linear combination of quantitative blood-brain barrier transport parameters allows classifying drugs according to their access to central nervous system with 94% overall accuracy.
Lanevskij, Kiril. "Absorption and Tissue Distribution of Drug-Like Compounds: Quantitative Structure-Activity Relationship Analysis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114235-89858.
Full textŠiame darbe pristatomi mechanistiniai kiekybinio struktūros ir aktyvumo ryšio modeliai, skirti vaistinių junginių savybių, charakterizuojančių jų absorbciją ir pasiskirstymą organizme prognozavimui. Nagrinėjama keletas parametrų, apibūdinančių paprastos difuzijos per biologines membranas greitį, taip pat termodinaminės konstantos, aprašančios vaistų pasiskirstymą tarp kraujo plazmos ir audinių. Ląstelinių pernašos barjerų pralaidumas buvo modeliuojamas netiesinėmis lygtimis, siejančiomis paprastos difuzijos greitį su vaistų fizikocheminėmis savybėmis, tokiomis kaip lipofiliškumas, jonizacija, vandenilinių ryšių sudarymo potencialas ir molekulių dydis. Nustatyta, kad smegenų endotelyje ir žarnyno epitelyje stebima panašaus pobūdžio difuzijos greičio priklausomybė nuo jonizacijos – katijonai ir anijonai difunduoja atitinkamai 2 ir 3 eilėmis lėčiau už neutralias molekules. Pademonstruota, kad analizuojant vaistų pasiskirstymo tarp audinių ir kraujo duomenis, būtina paversti pradines eksperimentines vertes kitais dydžiais, atspindinčiais vaistų jungimosi prie plazmos ir audinių komponentų stiprumą. Vaistų giminingumas audiniams gali būti aprašytas jų lipofiliškumu, o neigiama jonizacijos įtaka stebima tik rūgštiniams junginiams. Taip pat parodyta, kad vaistų pernašos per hematoencefalinę užtvarą kiekybinių parametrų tiesinė kombinacija leidžia 94% tikslumu klasifikuoti vaistus pagal jų prieinamumą centrinei nervų sistemai.
Li, Shijian. "Scalable User Assignment in Power Grids: A Data Driven Approach." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/1107.
Full textHERVE, FRANCOISE. "Pathologie du sein : contribution a l'elaboration du systeme adm." Rennes 1, 1992. http://www.theses.fr/1992REN1M020.
Full textLE, DOARE KOENIG ANNE-MARIE. "Medicaments et allaitement : contribution a l'etablissement du systeme adm." Rennes 1, 1992. http://www.theses.fr/1992REN1M095.
Full textBacchi, Reggiani Giacomo. "Analisi e riorganizzazione dei processi aziendali e dei flussi: il caso ADS2 Limited." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textAnnergren, Mariette. "ADMM for l1 Regularized Optimization Problems and Applications Oriented Input Design for MPC." Licentiate thesis, KTH, Reglerteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103618.
Full textQC 20121017
Blackwell, Scott. "The measurement, biological variation and response to acute inflammation of asymmetric dimethylarginine (ADMA)." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4912/.
Full textPiechota, Przemyslaw. "Development of in silico models for the prediction of toxicity incorporating ADME information." Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4554/.
Full textBareha, Younès. "Modélisation des processus de transformation de l'azote en digestion anaérobie : application à l'optimisation de la valorisation des digestats." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B067/document.
Full textEnergetic recovery of waste by anaerobic digestion leads to the production of a residue called digestate, which is composed of non-biodegraded organic matter and has a high content of ammoniacal and organic nitrogen. Due to this high nitrogen content, digestates are growing interest for the substitution of mineral fertilizers. The objective of this thesis is to understand the transformations of nitrogen that occur during anaerobic digestion in order to predict the nitrogen quality of digestates. This understanding of nitrogen transformation processes will allows the design and management of anaerobic digestion plants aiming at the optimization of the substitution of mineral fertilizers by digestates. To this end, two approaches were used in this work: (i) an experiment approach focused on the understanding of the bioaccessibility of organic nitrogen in relation to its biodegradability, and the understanding of the transformations of nitrogen in anaerobic digestion under laboratory and pilot conditions; and; (ii) a numerical approach where previously developed knowledge has been integrated in statistical and biokinetic modeling tools to predict the nitrogen properties of digestates according to substrate cocktails and residence time in the digester
Moda, Tiago Luiz. "Desenvolvimento de modelos in silico de propriedades de ADME para a triagem de novos candidatos a fármacos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22032007-112055/.
Full textMolecular modeling tools and quantitative structure-activity relantionships (QSAR) or structure-property (QSPR) are integrated into the drug design process in the search for new bioactive molecules with good pharmacokinetic and pharmacodynamic properties. The Medicinal Chemistry work carried out in this Masters dissertation concerned studies of the quantitative relationshisps between chemical structure and the pharmacokinetic properties oral bioavailability and plasma protein binding. In the present work, standard data sets for bioavailability and plasma protein binding were organized encompassing the structural information and corresponding pharmacokinetic data. The created data sets established the scientific basis for the development of predictive models using the hologram QSAR and VolSurf methods. The final HQSAR and VolSurf models posses high internal and external consistency with good correlative and predictive power. Due to the simplicity, robustness and effectivess, these models are useful guides in Medicinal Chemistry in the early stages of the drug discovery and development process.
Gardell, Fredrik. "Holography of SYK model." Thesis, Uppsala universitet, Teoretisk fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-365188.
Full textChen, Chi-Yuan. "Ab Initio Molecular Dynamics Simulation of Proton Transfer in Imidazole: An Atom-Centered Density Matrix Propagation (ADMP) Approach." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1141281810.
Full textTitle from electronic thesis title page (viewed Apr. 24, 2006). Includes abstract. Keywords: ADMP, proton, ONIOM, imidazole. Includes bibliographical references.
BOCHET, FLORENCE. "Pathologie des glandes salivaires : contribution a l'etablissement du systeme adm." Rennes 1, 1992. http://www.theses.fr/1992REN1M108.
Full textSOUZA, S. P. "Poder, saber e subjetividades: constituição e formação do sujeito ADM." Universidade Federal do Espírito Santo, 2011. http://repositorio.ufes.br/handle/10/2141.
Full textO estudo analisa a constituição e a formação dos sujeitos adm. Os materiais e a análise foram organizados em torno de três eixos: eixo das subjetividades, eixo dos poderes e eixo dos saberes. A seleção dos materiais, o modo de construir a análise e o texto, assim como os conceitos usados para pensar a formação em administração, foram possíveis a partir dos estudos de Michel Foucault sobre os códigos que regulam modos de se conduzir e sobre a produção de verdades que servem como justificativa. Os eixos são produções teórico-empíricas, pois neles estão as análises das entrevistas e as teorias, além das análises da formação em administração que ocorriam a partir de documentos, legislação e elementos históricos. As entrevistas, realizadas com professores que lecionam no curso de administração, alunos em vias de formação e administradores recém-egressos, serviram como disparadores das análises. Não se pretendeu produzir uma nova verdade sobre a formação em administração, mas, sim, mapear as condições de emergência dos sujeitos adm e de sua formação. Dentre as condições mapeadas estão os modos pelos quais somos governados, ou seja, os modelos de conduta que estão pautados nos modos de ação empresariais, a profissionalização, a sistematização do ensino e a constituição de um campo de conhecimento. Em suma, a pesquisa deparou-se com um processo de formação, via ensino superior, que pode levar tanto à reprodução de formas predominantes quanto à produção de rupturas com tais formas
Casadio, Alessandro. "Analisi delle linee di produzione e miglioramento dei processi aziendali: il caso ADS2 LTD." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Find full textSzoltys, Kryštof. "Parametrické CAD systémy a databáze součástí." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217957.
Full textCLERET, MIREILLE. "Apports des techniques informatiques en medecine : un exemple de systeme d'aide au diagnostic medical a partir de la base de connaissances adm." Rennes 1, 1994. http://www.theses.fr/1994REN1M064.
Full textGUERY, OLIVIER. "Evaluation de la base de connaissances adm a partir de donnees cliniques tirees de la litterature." Rennes 1, 1994. http://www.theses.fr/1994REN1M037.
Full textPovey, Adam Charles. "The application of optimal estimation retrieval to lidar observations." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:eb94de02-ad92-4eeb-b15c-094b05fa11c6.
Full textCubukgil, Evren. "Uncertainty and firm investment." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:c3fb67f9-adf2-41ac-98b9-cb2878e2b2d6.
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