Dissertations / Theses on the topic 'Adjunctive therapy'
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1
Massicotte, Eric M. "Adjunctive drug therapy for treatment of experimental hydrocephalus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0011/MQ53184.pdf.
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Hatzimanolakis, Penny. "Photodynamics : is this a viable adjunctive periodontal therapy?" Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7585.
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Objective: The aim of this study was to conduct a randomized in vivo clinical trial to assess the efficacy of a one time application of a phoactivated dye, methylene blue (PerioWaveTM) in treating chronic periodontal disease in humans.
Material and Methods: Thirty five periodontally maintained subjects with moderate to severe chronic periodontitis were randomly divided into a control group with nonsurgical periodontal debridement (NSPD) only versus an experimental group with NSPD and antimicrobial photodynamic therapy (APT). All teeth in both groups received periodontal treatment comprising of scaling, root planing, ultrasonics and local anaesthesia. The experimental group had the qualifying sites (pockets depths greater than 4.4 mm and bleeding on probing (BOP)) treated with the PerioWaveTM system and compared to the control group. The primary endpoint was clinical attachment level (CAL) and secondary endpoints were pocket depth (PD) and BOP. The endpoints and plaque were evaluated at baseline, 6 and 12 weeks by a blinded examiner.
Results: This study showed PerioWaveTM as a one time application of a cold diode laser with a wavelength of 670nm; a maximum power of 150mw; an average energy density of 20 J/cm²; a phenothiazine photosensitizer (methylene blue) in a concentration of 0.01% wt/vol; and at an optimal activation time of 60 seconds per mesiodistal surface had no statistical significance in the treated qualifying sites with regards to CAL (p=.69; p=.97) or PD (p=.14; p=.23) at 6 or 12 weeks after treatment over the NSPD group. However BOP did have a statistical significance over the control group at 6 weeks (p=.05) but not at 12 weeks (p=.47).
Conclusions: In patients with advanced chronic periodontitis, CAL and PD did not show improvement with one time application of the PerioWaveTM photodynamic system over conventional NSPD. However, the lack of BOP did have a short time (6 weeks) reduction.
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Kirkman, Danielle Louise. "Exercise as adjunctive therapy in chronic kidney disease." Thesis, Bangor University, 2013. https://research.bangor.ac.uk/portal/en/theses/exercise-as-adjunctive-therapy-in-chronic-kidney-disease(a8f961d2-6026-429c-aa7d-e18a6ffef1bf).html.
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Background. Exercise is a natural medicine that has been prescribed for the prevention and management of chronic diseases, to enhance quality of life, improve health status and promote longevity. Current efforts to implement exercise as routine practice in the conventional renal replacement therapy population have been hampered by a lack of randomised controlled data. The aim of this thesis was to investigate the effect of exercise as an adjunctive therapy to enhance outcomes pertaining to renal transplantation, vascular access, haemodialysis adequacy and muscle wasting in Stage 4 and 5 Chronic Kidney Disease patients. It was hypothesised that randomised controlled trials employing gold standard outcome measures would reveal significant beneficial effects of exercise that are strongly associated with quality of life, hospitalisation and survival in this patient population. Reports. The first report presents a systematic literature review of exercise in the kidney transplant population. The largest positive effects were noted on intermediate outcomes such as aerobic fitness and muscle strength. Presumably these adaptations contributed to the trends observed for improvement in quality of life. Whether exercise impacts on outcomes associated with longevity of life requires further study. The rest of the thesis focused on patients receiving the more popular form of renal replacement therapy, haemodialysis. The first empirical study of the thesis, appertaining to vascular access, investigated the feasibility of implementing a post-operative forearm exercise intervention for arteriovenous fistula maturation. Exercise had no effect on primary outcomes measures of arterial diameter (95% Cl, -0.24 [-1.12; 0.51] mm) and venous diameter (95% Cl, 0.16 [-1.84; 1.24] mm). It was concluded that future randomized controlled trials should investigate a similar protocol implemented before arteriovenous fistula creation to enhance surgery success and maturation. The second randomised controlled trial explored the effect of intradialytic exercise, in comparison to the traditional prescription of increased dialysis time, to enhance dialysis adequacy and solute removal. Increased haemodialysis time, but not exercise, increased equilibrated Kt/V urea compared to control trials (Extra time vs. control: 95% Cl, 0.15 [0.05; 0.26], P < 0.05; exercise vs. control: 95% Cl, 0.03 [-0.05; 0.12], P > 0.05). Exercise, but not increased time, increased phosphate reduction ratio (exercise vs. control: 95% Cl, 8.6 [0.5; 16.7] %,p < 0.05; extra time vs. control: 95% Cl, 5.0 [-1.0; 11.1] %, p > 0.05). Thus intradialytic exercise cannot replace the traditional prescription of increased haemodialysis time for improving dialysis efficacy, but may be a useful adjunctive therapy for serum phosphate control. The third study implemented a randomised controlled trial of intradialytic progressive resistance training for treating muscle wasting. The primary outcome measure of thigh muscle volume, as measured by magnetic resonance imaging, significantly increased following 12 weeks of training compared to a sham exercise control (95% Cl, 193 [63; 324] cm3). Intradialytic resistance exercise elicited an anabolic and strength response in haemodialysis patients. However, a surprising lack of a change in functional capacity despite increased muscle mass warrants further investigation. Conclusion. The findings suggested that exercise had a beneficial effect on factors relating to outcomes in Stages 4 and 5 Chronic Kidney Disease patients. However, to ensure effectiveness of interventions and to maximize programme efficiency, careful consideration of basic exercise and physiological principles is required. Nevertheless, the observed benefits of exercising outweighed its risks, thus supporting the initiative for exercise prescription as an adjunctive therapy for the management of this disease state.
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Parrish, A. G. "Cost-effectiveness of nebulised ipratropium as adjunctive therapy in acute asthma." Master's thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/24972.
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Aim: To determine whether the addition of nebulised ipratropium to the therapy of acute asthma leads to a cost-effective reduction in the mean duration of admission and time to maximum peak expiratory flow rate (PEFR). Method: Patients with an admission diagnosis of acute asthma were studied in a double-blind, placebo-controlled trial in which they received a standard therapeutic regimen of continuous intravenous aminophylline, 4-hourly fenoterol nebulisation, intravenous methylprednisolone 125mg 12-hourly, and, every four hours, either nebulised saline placebo or ipratropium bromide 500mcg in 3ml saline. Data on age, gender, initial and maximum PEFR, time to maximum PEFR, and duration of hospital stay was collected from the hospital record after discharge. Statistical techniques: 2-way contingency tables for categorical variables, 1-way ANOVA for treatment effects, and life-table analysis of the time till discharge. Results: Records of 279 of the 400 patients entered in the study were suitable for analysis after excluding re-admissions, non-asthmatics and incomplete records. Baseline comparisons of age and severity on presentation showed no significant differences. The trial group did not differ significantly from the control group with respect to either time to PEFR (respectively 21.11 hours (SD 14.3) versus 22.89 (SD 15.82)) or duration of admission (5.02 (SD 3.65) versus 5.38 (SD 3.13) 6-hour units). In a sub-group of patients (n=155) demonstrating more than 100% improvement in PEFR, the time to maximum PEFR was significantly shorter in the ipratropium group (20.35 hours SD 12.4) versus 25.20 hours (SD 17.0); p= 0.045). Conclusion: The addition of ipratropium bromide to a standard treatment regimen for acute asthma reduced the time to achieve maximum PEFR in a sub-group of patients with markedly reversible airflow limitation. Overall, however, the addition did not prove cost-effective.
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Bodnar, Sallyjane E. "Family therapy and creative visualisation : an adjunctive treatment for allergies in children." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29188.
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The purpose of the study was to explore the use of Creative Visualization in the context of Family Therapy for treatment of a family of a child with allergies. Based on a single-case research design, the study included pre- and posttest measures; baseline, continuous, and follow-up self-report of symptoms; plus examination of physician's clinical records to determine the efficacy of the intervention. A further purpose of the study was to explore the possible usefulness of a test being developed on the basis of the Psychosomatic Family Model, the Leuven Family Assessment, as an outcome measure.
The subject family was an intact family with one adolescent daughter whose most important allergic symptom was poorly controlled asthma, at least partially due to noncompliance
with medical advice.
The measures included the Leuven Family Assessment, a measure based on the Psychosomatic Family Model, which has been developed for use with families of children with eating disorders; the Family Adaptability and Cohesion Scale (FACES III), a measure based on the Circumplex Family Model, which is a well-accepted measure of family functioning; symptom self-report; and consultation with the child's physician to report hospital admissions and emergency room visits.
The baseline period was two weeks, the intervention consisted of two weeks of Relaxation Training and eight weekly meetings for combined Family Therapy and Creative Visualization, and the follow-up consisted of telephone contact with the symptomatic adolescent beginning fourteen weeks after the last family therapy session and continuing for eight weeks.
Post-therapy results show a trend toward expected changes in family structure and functioning and marked improvement in the asthmatic symptoms of the adolescent.
Creative Visualization is an intervention tool well worth further exploration in the context of family therapy; and the Leuven Family Assessment merits further investigation and development as an outcome measure.Education, Faculty of
Educational and Counselling Psychology, and Special Education (ECPS), Department of
Graduate
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Yeung, Wing-kwan Rosa. "Adjunctive effect on hormone replacement therapy on periodontal treatment responses in postmenopausal women." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3765195X.
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Yeung, Wing-kwan Rosa, and 楊穎筠. "Adjunctive effect on hormone replacement therapy on periodontal treatment responses in postmenopausal women." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B3765195X.
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Puligheddu, Monica Maria Francesca <1969>. "Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy (NFLE)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7057/.
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Nocturnal Frontal Lobe Epilepsy (NFLE) is characterized by onset during infancy or childhood with persistence in adulthood, family history of similar nocturnal episodes simulating non-REM parasomnias (sleep terrors or sleepwalking), general absence of morphological substrates, often by normal interictal electroencephalographical recordings (EEGs) during wakefulness. A family history of epilepsy may be present with Mendelian autosomal dominant inheritance has been described in some families. Recent studies indicate the involvement of neuronal nicotinic acetylcholine receptors (nAChRs) in the molecular mechanisms of NFLE. Mutations in the genes encoding for the α4 (CHRNA4) and ß2 (CHRNB2) subunits of the nAChR induce changes in the biophysical properties of nAChR, resulting generally in a “gain of function”. Preclinical studies report that activation of a nuclear receptor called type peroxisome proliferator-activated receptor (PPAR-α) by endogenous molecules or by medications (e.g. fenofibrate) reduces the activity of the nAChR and, therefore, may decrease the frequency of seizures. Thus, we hypothesize that negative modulation of nAChRs might represent a therapeutic strategy to be explored for pharmacological treatment of this form of epilepsy, which only partially responds to conventional antiepileptic drugs. In fact, carbamazepine, the current medication for NFLE, abolishes the seizures only in one third of the patients.
The aim of the project is:
1)_to verify the clinical efficacy of adjunctive therapy with fenofibrate in pharmacoresistant NFLE and ADNFLE patients; focousing on the analysis of the polysomnographic action of the PPAR- agonist (fenofibrate).
2)_to demonstrate the subtended mechanism of efficacy by means of electrophysiological and behavioral experiments in an animal model of the disease: particularly, transgenic mice carrying the mutation in the nAChR 4 subunit (Chrna4S252F) homologous to that found in the humans. Given that a PPAR-α agonist, FENOFIBRATE, already clinically utilized for lipid metabolism disorders, provides a promising therapeutic avenue in the treatment of NFLE\ADNFLE.
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Ruiz, Magaz Vanessa. "Efficacy of adjunctive Er,Cr:YSGG laser application following scaling and root planing in periodontally diseased patients." Doctoral thesis, Universitat Internacional de Catalunya, 2015. http://hdl.handle.net/10803/310948.
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Scientific rationale for study
The literature about lasers in the field of periodontology is contradictory. The present study aimed at evaluating benefits of Er, Cr: YSGG laser irradiation following deep scaling compared to scaling alone in a randomized controlled clinical trial based on an appropriate sample size.
Principal Findings
The present study demonstrated that laser irradiation combined with conventional Sc/RP did not improve the clinical outcomes regarding probing pocket depth reduction and attachment level gain compared to Sc/RP alone.
Practical implications
Taken into account that lasers are expensive devices and no superior results can be expected by using them, their recommendation for clinical application is still questionable.Justificació de l´estudi La literatura sobre l´ús de làser en el camp de la periodòncia és contradictori. Aquest estudi té com objectiu evaluar els beneficits de la irradiació amb làser d´Er,Cr:YSGG després de realitzar un raspat de les arrels comparat amb el raspat sense aplicar làser en un estudi clínic randomitzat amb un tamany mostral adequat. Resultats principals Aquest estudi ha demostrat que la irradiació de láser Er,Cr:YSGG combinada amb el tractament convencional de raspat I allisat radicular no millora les variables clíniques en la disminució de la profunditat de bossa i del augment del nivell d´inserció clínica. Implicacions pràctiques Tenint en compte que els aparells de làsers son costosos i que els resultats obtinguts no son superiors al tractament convencional, la recomanació d´aplicació clínica és a data d´avui encara qüestionable.
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Qian, Cheng. "The effect of angiotensin (1-7) on bone marrow stem cells adjunctive pharmacological therapy for cell transplantation in heart failure /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
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Armour, Erin Nicole. "Animal-Assisted Therapy: An Adjunctive Intervention for Reducing Depression and Anxiety in Female College Students with Physical Disabilities and Guidelines for Implementation into Psychotherapy Practice and Research." Wright State University Professional Psychology Program / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wsupsych1312224111.
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Talbott-Green, Marlene. "A comparative study of feminist group psychotherapy and poetry therapy as an adjunctive treatment to increase self-actualization on the personal orientation inventory." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1346941533.
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Talbott-Green, Marlene Ann. "A comparative study of feminist group psychotherapy and poetry therapy as an adjunctive treatment to increase self-actualization on the Personal Orientation Inventory /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487590702991324.
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Ralph, Anna. "Pulmonary Tuberculosis: towards improved adjunctive therapies." Phd thesis, 2010. http://hdl.handle.net/1885/7336.
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The potential to improve pulmonary tuberculosis (PTB) treatment outcomes with adjunctive immunotherapies requires investigation. L-arginine and vitamin D have antimycobacterial properties which render them suitable candidates. Therefore the Arginine and Vitamin D Adjunctive therapy in Pulmonary TB (AVDAPT) trial evaluates these supplements in PTB. This trial commenced in June 2008 in Timika, Papua Province, Indonesia, through a collaboration between the International Health Division, Menzies School of Health Research (Darwin, Australia), the National Institute for Health Research and Development (Ministry of Health, Indonesia), and the Australian National University (Canberra)...This thesis provides the basis for continuation of the AVDAPT study, produces original findings relating to clinico-immunological aspects of PTB, and provides information of major local importance to help guide TB service provision in Timika.National Health and Medical Research Council for providing a Postgraduate scholarship and a 2009 research grant, and the Australian Respiratory Council and the Royal Australasian College of Physicians (Covance award) which generously provided funds for the project.
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Cameron, Shelley J. L. "Art therapy : a viable adjunctive intervention for adults diagnosed with cancer." Thesis, 1996. http://spectrum.library.concordia.ca/2571/1/MM18459.pdf.
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Lee, Yuan-Wen, and 李元文. "Traditional Chinese Medicine as Adjunctive Therapy for Patients with Advanced Breast Cancer." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/37gmmr.
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博士臺北醫學大學
藥學系(碩博士班)
102
Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines employed in the treatment of breast cancer patients. However, the clinical evidences of TCM in large scale studies on survival, which is the major concern for breast cancer patients are still lacking. This study used the Taiwan National Health Insurance Research Database (NHIRD) to conduct a retrospective population-based cohort study of advanced breast cancer patients between 2001 and 2010. The patients were separated into TCM user and nonuser groups, and Cox regression models were applied to determine the association between the use of TCM and patient survival. In addition, this study investigated the effects on systemic infection, severe complications, analgesic usage, and health care utilization when using TCM in this specific population. Total of 729 advanced breast cancer patients receiving taxanes were included in this study, 115 TCM users and 614 TCM nonusers with the mean age of 52.0 years. The mean time of follow-up was 2.8 years, with 277 deaths during the 10-year period. Multivariate analysis demonstrated that, compared with nonusers, the use of TCM was associated with a significantly decreased risk of all-cause mortality (adjusted hazard ratio [HR], 0.55 [95% CI, 0.33–0.90] for TCM use for 30-180 days; adjusted HR, 0.46 [95% CI, 0.27–0.78] for use more than 180 days). Further analysis in 115 TCM users, the most frequent TCMs used by breast cancer patients were Jia Wei Xiao Yao San, Pu Gong Ying, and Bai Hua She She Cao. In addition, the results showed that the use of TCM would reduce systemic infection, analgesic usage, and the length of hospitalization for these cancer patients. Adjunctive TCM therapy with taxanes may lower the risk of death and systemic infection in advanced breast cancer patients. It could also reduce analgesic usage and the length of hospitalization among these patients. Future randomized controlled trials are still needed to validate these findings.
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Chang, Hsiao-Wei, and 張曉維. "Outcomes of adjunctive aerosolized aminoglycosides in intravenous antibiotics therapy for Pseudomonas aeruginosa pneumonia." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/te654w.
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碩士高雄醫學大學
藥學系碩士在職專班
103
Background: It is common that pneumonia of the ICU in Taiwan is caused by Pseudomonas aeruginosa. Due to the abuse of antibiotic prescription, the resistance of Pseudomonas aeruginosa is increasing. The previous study shows that when treating pulmonary infection, inhaled antibiotics yields higher pulmonary concentrations than intravenous administration. Whether the follow up efficacy also increased with the higher pulmonary antibiotic concentration is yet to be proven by evidence. Study design, location and subjects: This study was conducted south of a regional teaching hospital for the single-center, retrospective study of medical records. The study objects are those age between 20 and 99 years old, infected with Pseudomonas aeruginosa pneumonia in ICU and confirmed by bacterial culture from January 1st 2010 to December 31th 2013. Based on treatment methods, patients are divided into two groups, one is given antibiotics by intravenous route only and the other group is given intravenous and inhaled antibiotics in combination. Methods: All patients’ basic information and clinical data are collected by chart review. Clinical data are divided by timeline and recorded days of patients’ ICU stay, days of ventilation patient use, improvement of clinical symptoms of pneumonia and the incidence of drug-resistant bacteria, etc. Use Acute Physiology and Chronic Health Evaluation Score and Clinical Pulmonary Infection Score as assessment tool. The endpoint is mortality of 30 days after infection and all data undergo statistical analysis and comparison. Statistical analysis includes chi-square test (χ2 test), T test (t-test), and Fisher exact test (Fisher''s exact test). Results: During the study period from January 1st 2010 to December 31th 2013, a total of 67 patients were included, 44 of them used monotherapy (intravenous antibiotics alone) and 23 of then used combination therapy(intravenous and inhaled antibiotics). The patients information showed that the average age was 76.5 years old(standard deviation 13.9), male to female ratio was 71.6% to 28.4%. In comparison between the two group, other than male percentage in monotherapy group (p-0.047), there were no significant differences between the two group before treatment in age, Acute Physiology and Chronic Health Evaluation score, Clinical Pulmonary Infection Score, renal function, other infection site. More than 80 percent of patients'' age in both groups were over 60. After treatment, there were no significant difference in days of ICU stays (p= 0.452), days or ventilator use (p= 0.061), days of intravenous injection of antibiotics(p= 0.066), Acute Physiology and Chronic Health Evaluation score (p= 0.589), difference of Clinical Pulmonary Infection Scale before and after treatment (p= 0.078), ratio of elevated creatinine value more than 1(p= 0.523), re-cultured Pseudomonas aeruginosa (p= 0.46), cultured drug-resistance Pseudomonas aeruginosa(p= 0.603), or 30-day mortality(p= 0.308). Conclusions: In comparison of monotherapy with combination therapy, the latter posed no effect on renal function but yielded not significantly difference regarding symptoms of pneumonia, days of intravenous injection, days of ICU stays, Acute Physiology and Chronic Health Evaluation score when leaving ICU, re-infected rate of Pseudomonas aeruginosa, or drug resistance strains. Due to our study was a chart review retrospective one, there were more limitation comparing to prospective study with respect to strict protocol. Therefore our study was not representative of the entire patient populations. To clear all predictive variables, the best method was still prospective trials available to control various of confounding factors.
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TSAI, CHIA-LING, and 蔡佳玲. "The Empirical Study of Yoga Adjunctive Therapy to Improve Positive and Negative Symptoms of Schizophrenia." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/e792m3.
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碩士中臺科技大學
護理系碩士班
107
Drug therapy is the major treatment for schizophrenia, and adjunctive therapy has been widely recognized for improving drug side effects and soothing symptoms. The purpose of this study was to investigate the effect of yoga adjunctive therapy on the improvement of positive and negative symptoms of schizophrenic disorders. In the systematic reviews examine the training prescriptions and meta-analysis of yoga adjunctive therapy in schizophrenic patient to compare the effects of yoga, exercise, and conventional treatment on positive and negative symptoms of schizophrenia. According to empirical research, we process from the formation of problems, literature search, screening of literature, literature quality evaluation, extraction integration and evaluation of results. And search for related literatures in The Cochrane Library, PubMed, CINAHL, Medline and Taiwan Master's Thesis System, Taiwan Journal Paper Index System, Airiti Library Huayi Online Library, etc. before May 2018. Search for keywords: Schizophrenia or schizoaffective or psychosis or psychotic, yoga or yogic or yogi, also search for literature published in Chinese and English journals at home and abroad, to find out that it is relevant for the purpose of this study. The article was included in the review for analysis. A total of 12 research samples were included for systematic reviews. The yoga training was guided by a yoga professional or coach. The short-term intervention was 4-8 weeks. The frequency of yoga was 3 to 7 days per week and each session no more than 60min. Seven of the study samples entered the meta-analysis and found that 8-week yoga adjunctive therapy had a significant effect on improving positive symptoms compared with conventional therapy (p = .05), but did not achieve significant effect on improving negative symptoms (p = .40). Compared with conventional treatment, the 12-week comparison of yoga adjunctive therapy had a significant effect on improving the PANSS total score (p < .00001). There was no significant difference between the improvement of positive symptoms (p = .08) and negative symptoms (p = .55) between the yoga group and the exercise group at 16 weeks. The comprehensive conclusion is that yoga adjunctive therapy is still superior to conventional treatment in reducing the severity of positive symptoms and negative symptoms, so it can be used as a reference for clinical practice and research.
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Schulte, April L. "Using traditional Chinese medicine as adjunctive therapy in the treatment of non-insulin dependent diabetes mellitus." 2004. http://www.ocomlibrary.org/images/PDF/studentpapers/aprilschulte.pdf.
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TSAI, WEN-PING, and 蔡文萍. "The Impacts of Participating Day Care Adjunctive Therapy on the Mild Dementia Elderly Caregivers’ Caregiving Load." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/vzctht.
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碩士國立暨南國際大學
社會政策與社會工作學系
105
The increase of the elderly population has been a global phenomenon. As the population ages quickly, there are more and more people with dementia. Most elderly with dementia are cared for by family members and the biggest issue for caregivers is the behaviors and mental health of the elderly with dementia. Their behaviors and mental health not only makes caregiving much more difficult but also increases the caregiving load. However, such elderly’s regular participation in activities can help delay the loss of cognitive abilities, increase involvement in the society and relieve caregiving load from caregivers. Therefore, this thesis is to research the impact of the elderly with mild dementia receiving day care adjuvant therapy on caregivers’ caregiving load. This research focuses on quantitative research and the data is gathered from interviews. Interview participants are caregivers for the elderly with dementia who receive day care adjuvant therapy and are located across four cities in central Taiwan, including Miaoli, Taichung, Changhua and Nantou. 109 questionnaires in total were received and qualitative interviews were conducted to supplement quantitative data. In-depth interviews were conducted with 4 caregivers for the elderly with mild dementia. The following are findings from organizing and analyzing the data: 1.The major factors on the caregiving load of caregivers for the elderly with dementia include caregiving work, the relationship with the elderly after dementia took place and the frequency of memory and behavior problems from the elderly with dementia. These are highly related to caregivers’ caregiving load. The whole model’s explanatory power is 38.2%. 2.The qualitative interviews show that behavioral issues from the elderly with dementia are different from those from the elderly without dementia. These behavioral issues impact the relationship between the caregiver and the one receiving care, roles and responsibilities, psychological and mental stress, family relationships, daily life and etc. If multiple family members share caregiving responsibilities or support each other, caregivers can find ways to reduce the stress, which help reduce caregiving load. 3.The caregiving load of the primary caregivers is heavy in the Taiwanese society. When evaluating the factors to caregivers’ caregiving load, one should also evaluate the intertwined impact of the elderly’s background, the primary caregiver’s background, memory and behavior issues and day care adjuvant therapy.
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"In vivo tests of resistance to chloroquine by malaria parasites using adjunctive primaquine therapy and prophylaxis." Tulane University, 1994.
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Resistance to the blood schizonticidal drug chloroquine by malaria parasites causes severe problems where malaria is endemic. A better means of testing for resistance to chloroquine by malaria parasites may improve the efficacy of public health strategies for controlling morbidity and mortality caused by this disease. Resistance to chloroquine by Plasmodium vivax may be an important emerging problem, but there is no established procedure for detecting resistant strains. One possible approach is a primaquine adjunct to a standard in vivo test of resistance. Primaquine is a tissue schizonticidal drug with little blood schizonticidal activity. Thus, primaquine may prevent the emergence of liver stage parasites without effecting the outcome of blood schizonticidal therapy. This strategy was evaluated by first demonstrating the prophylactic efficacy of primaquine, and then by examining its effect on 28 day in vivo tests of resistance to chloroquine by P. falciparum and P. vivax. Although primaquine appeared efficacious and tolerated for prophylaxis, trials of the adjunct showed that primaquine inhibited recrudescences following chloroquine therapy. The primaquine adjunct caused underestimation of the frequency of resistance to chloroquine by P. vivax and cannot be used as an adjunct to in vivo tests of resistanceacase@tulane.edu
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"Compound formula of danshen (salvia miltiorrhiza) and gegen (pueraria lobata) as adjunctive secondary preventive therapy in coronary patients." 2004. http://library.cuhk.edu.hk/record=b5891956.
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Tam Wing Yin.Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.
Includes bibliographical references (leaves 82-100).
Abstracts in English and Chinese.
English abstrac --- p.I
中文摘要 --- p.VI
Glossary --- p.X
Chapter Chapter 1. --- Background:
Chapter 1.1. --- Coronary heart disease in Hong Kong --- p.1
Chapter 1.2. --- Coronary heart disease and atherosclerosis --- p.2
Chapter 1.3. --- Pathogenesis of atherosclerosis --- p.2
Chapter 1.4. --- Risk factors for atherosclerosis --- p.5
Chapter 1.5. --- Homocysteine --- p.6
Chapter 1.6. --- Folate --- p.10
Chapter 1.7. --- Vitamin B12 --- p.13
Chapter 1.8. --- Adhesion Molecules --- p.14
Chapter 1.9. --- Phytoestrogen --- p.17
Chapter 1.10. --- Secondary prevention of coronary artery disease --- p.20
Chapter Chapter 2. --- "Heart disease, Danshen and Gegen in Chinese medicine"
Chapter 2.1. --- The record of Cardiac symptoms in Chinese Medicine --- p.24
Chapter 2.2. --- Danshen (Salvia Miltriorrhiza) --- p.25
Chapter 2.3. --- Gegen (Radix Pueraria) --- p.28
Chapter Chapter 3. --- Surrogate atherosclerotic markers
Chapter 3.1. --- Flow-mediated dilatation of brachial artery (FMD) --- p.31
Chapter 3.2. --- Carotid intima media thickness (IMT) --- p.32
Chapter Chapter 4. --- Method
Chapter 4.1. --- Rational of the study --- p.33
Chapter 4.2. --- Clinical protocol --- p.35
Chapter 4.3. --- Measurement of plasma homocysteine --- p.38
Chapter 4.4. --- Measurement of folate and vitamin B12 --- p.40
Chapter 4.5. --- Measurement of soluble cellular adhesion molecules (CAMs) --- p.41
Chapter 4.6. --- Measurement of plasma enterolactone --- p.43
Chapter 4.7. --- Measurement of plasma hs-C-reactive protein --- p.44
Chapter 4.8. --- Other laboratory tests --- p.45
Chapter 4.9. --- High resolution ultrasound imaging --- p.46
Chapter 4.10. --- Statistical analysis --- p.49
Chapter 4.11. --- My contribution to this joint project --- p.49
Chapter Chapter 5. --- Results
Chapter 5.1. --- Recruitment and outcomes of subjects --- p.51
Chapter 5.2. --- Baseline characteristics --- p.53
Chapter 5.3. --- Medical history and treatment received in the study subjects --- p.54
Chapter 5.4. --- Safety profiles --- p.55
Chapter 5.5. --- Severe adverse events --- p.56
Chapter 5.6. --- Lipid profiles --- p.57
Chapter 5.7. --- Secondary endpoints --- p.58
Chapter 5.8. --- Primary endopoints --- p.59
Chapter 5.9. --- The effect of statin usage on the primary endpoints
Chapter 5.10. --- The major determinant of the change in FMD by multivariate logistic regression
Chapter 5.11. --- Progress of lipid profiles and primary endpoints in the open label phase
Chapter Chapter 6. --- Discussion
Chapter 6.1. --- Brachial FMD --- p.66
Chapter 6.2. --- Carotid IMT --- p.69
Chapter 6.3. --- Brachial GTN --- p.70
Chapter 6.4. --- Lipid-lowering effect --- p.72
Chapter 6.5. --- Phytoestrogen --- p.72
Chapter 6.6. --- Folate --- p.73
Chapter 6.7. --- Vitamin B12 and glucose --- p.76
Chapter 6.8. --- Summary of possible anti-atherogenic mechanism of D&G --- p.76
Chapter 6.9. --- Placebo effect --- p.77
Chapter 6.10. --- Safety profile --- p.77
Chapter 6.11. --- Limitation of the study and suggestion of solution --- p.77
Chapter 6.12. --- Suggestions and ummary of the future work --- p.79
Chapter Chapter 7. --- Conclusions --- p.81
References --- p.82
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Huang, Xian-Wen, and 黃獻文. "Using Cancer Registry Database to Investigate the Influences of Adjunctive Traditional Chinese Medicine Therapy on Survival in Breast Cancer Patients." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/w552m5.
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Chen, Ya-Wen, and 陳雅雯. "The Adjunctive Effect of Multiple Antimicrobial Photodynamic Therapy in The Non-surgical Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61656867662252873517.
Full textAbstract:
碩士國立臺灣大學
公共衛生碩士學位學程
103
Periodontitis is the most common chronic oral disease. Periodontitis involves the periodontal tissue including gingiva, alveolar bone and periodontal ligament. Gingivitis and chronic periodontitis are frequently in clinical examination. The symptom and sign of gingivitis mostly confined to gingival tissue, gingival redness, swelling, pain, and gingival bleeding while brushing. Periodontitis the symptoms and signs of gingivitis, but the alveolar bone beneath the gingiva and periodontal ligament. There are 500-600 species of bacteria in the oral environment, existing on the tooth surface, mucosa and saliva. The bacteria species alter in different oral ecological environments. Different bacteria together a biofilm. The bacteria extracted from the periodontal pockets were mainly Gram''s negative anaerobic bacteria. Based on current literture, the periodontal disease pathogenic mechanism is caused by toxins released by the pathogenic bacteria. The toxins would evoke the gingival tissue and the host would the immune response to react. Cytokines and histodialysis enzymes are released during the process, causing alveolar bone and tissue destruction. The degree and extent of destruction depends on the defensive system function, leukocyte ability, genetic variances or environment differences, for example, inadequate oral hygiene, smoking habits, and systemic condition factors. There are 1 hundred million bacteria in 1 milligram of plaque. Inadequate oral hygiene environment increases the amount of bacteria accumulated on the tooth surface or gingival sulcus by 2 to 10 folds. Periodontal disease treatment focuses on supragingival and subgingival plaque and calculus removal. This experiment examined the adjunctive effect of photodynamic therapy on nonsurgically-treated chronic periodontitis patients. During the course of treatment, periodontal curette was applied to remove the subgingival calculus and inflammation tissue. Correct and effective oral hygiene care instructions and tooth-brushing techniques were given to the patients to reduce the amount of plaque. Clinical trial 36 patients aged between 35 to 70 years old with chronic periodontitis. At least 16 teeth in the oral cavity. Incisor, canine, or premolar teeth in the same arch on different sides were selected in pairs, and there were at least two sites with periodontal probing depth than 5mm, periodontal attachment level than 4mm as the experimental group and control group. Patients not under antibiotic medication or periodontal treatment in six month. The course of this clinical trial was arranged into two steps. In the first step, participants were all treated with scaling and root planing as full mouth periodontal nonsurgical treatment. Split mouth, the participants were into two groups experimental group then photodynamic therapy as adjunctive treatment for the nonsurgically-treated chronic periodontitis patients. And the control group injection saline as placebo for adjunctive treatment. After the photodynamic therapy and nonsurgical periodontal treatment, periodontal pocket depth, tooth mobility, and keratinized degree of gingiva were. Also, the amount of periodontal pathogenic bacteria and the amount of sulfide compound in the oral cavity were .
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Chen, Su-Jing, and 陳素靜. "The Effects of Traditional Chinese Medicine as adjunctive Therapy on Survival Rate of Cancer Patients: Breast Cancer, Lung Cancer and Colorectal Cancer for example." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/88pc65.
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Yuan, Tzu-Chieh, and 袁梓捷. "Application of Computer Tomography Image for 3-D Recon-struction in Children Tracheal Stenosis as Adjunctive Therapy and Build the Normal Children Trachea Length Model." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/36322452710368808292.
Full textAbstract:
碩士國立臺灣科技大學
自動化及控制研究所
102
This research applied image processing techniques to children tracheal stenosis. Children with tracheal stenosis have a direct impact on their daily lives. Through medication or surgery, we must keep track of their conditions to prevent possible subsequent restenosis. The tracheal cross-sectional area and volume were important references for clinicians on the diagnosis. This research used a computerized to-mography scan of tracheal stenosis to execute a three-dimensional re-construction, and accurately calculate the cross-sectional area and volume as a clinical diagnosis of the assistant system. This research could be divided into two parts. The first part was using image processing techniques to analysis computer tomography image and data calculation. This research developed a newly improved median filter, which could effectively eliminate noises and keep the texture of the image. A tracheal-capturing process was designed. First, applied region growing method to the first image and gain its edge coordinates. Then the center of the coordinate was used to replace the growing seed for the next image. The edge of the coordinate calculation was used to calculate the shrink reference array. Then the shrink ref-erence array was used as a starting contour for distance regularized level set evolution and iteratively grown to sectional area. Finally, through iso-surface extraction technology the Three-dimensional re-construction image was built with combination of Cotton law after calculating cross-sectional area and volume. This research proposed a domestic children tracheal stenosis treatment standard, with 100% accuracy from clinician’s actual sample verification of Taipei Mackay Memorial Hospital. The result verified the effectiveness of our pro-posed three dimensional reconstruction. By using tracheal stenosis computer tomography image and calculation of sectional area and volume, our proposed system could be effectively assisting clinical diagnosis for doctors. The second part was to predict the normal trachea length in the normal children's BMI values. In this research, curve fitting was used to make a children normal trachea length prediction model with 155 groups of bronchoscopy data. In verification experiment, the model’s confidence interval is 95%, RMSE is 6.382. It proved that this new reference model could be provided for subsequent clinical studies and medical science. Keyword: tracheal stenosis, distance regularized level set evolution, iso-surfaces extraction technique, children normal trachea length model