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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

Langilotti, Frank T. Adjunctive therapy. Glen Head, N.Y: New York Chiropractic College, 1985.

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2

L, Ziffer Robert, ed. Adjunctive techniques in family therapy. Orlando: Grune & Stratton, 1985.

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3

R, Bates Eric, ed. Thrombolysis and adjunctive therapy for acute myocardial infarction. New York: Dekker, 1993.

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4

Michael, Lerner. Integral cancer therapy: A work in progress and adjunctive cancer therapies with a primary emphasis on intelligent and informed personal choice in the integration of conventional adjunctive and alternative treatment systems. Bolinas, Calif: Commonweal, 1985.

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5

Langilotti, Frank T. Adjunctive Therapy: 1985 Edition. New York Chiropractic College, 1985.

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6

Reffelmann, Thorsten, and Robert Kloner. Adjunctive Reperfusion Therapy Post-AMI. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199544769.003.0009.

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• Reperfusion of the occluded coronary artery in an ST-segment-elevation myocardial infarction is the most effective approach for reducing infarct size, preserving left ventricular ejection fraction, lowering the incidence and severity of congestive heart failure and improving prognosis• Hence, several pharmacologic agents intended to improve target vessel patency as an adjunct to thrombolysis or primary percutaneous coronary intervention have been shown to be beneficial in patients with reperfusion therapy for acute myocardial infarction, namely antiplatelet and anticoagulation agents• Animal investigations have suggested that coronary reperfusion may also result in undesirable cardiac alterations, termed ‘reperfusion injury’, such as reversible contractile dysfunction (‘stunning’), microvascular obstruction (‘no-reflow’), and in several studies the progression of myocardial necrosis (‘lethal reperfusion injury’)• Clinical investigations of various pharmacologic interventions as an adjunctive therapy to reperfusion to reduce final infarct size, the amount of contractile dysfunction and to improve prognosis have been mostly inconsistent; only a few interventions, e.g. adenosine and atrial natriuretic peptide seem to show promise at least in certain subgroups.
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7

Nortier, J. W. R. Nortier : adjunctive medical therapy pb Crs 2: Adjunctive medical therapy pb Crs 2. De Gruyter, Inc., 2019.

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8

Cummings, Nicholas A., and William O'Donohue. Evidence-Based Adjunctive Treatments. Elsevier Science & Technology Books, 2011.

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9

Woolf, Eric C., and Adrienne C. Scheck. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0013.

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Malignant brain tumors are devastating, and increased survival requires new therapeutic modalities. Metabolic dysregulation results in an increased need for glucose in tumor cells, suggesting that reduced tumor growth could be achieved with decreased glucose availability either through pharmacological means or use of a high-fat, low-carbohydrate ketogenic diet (KD). KD provides increased blood ketones to support energy needs of normal tissues and has been shown to reduce tumor growth, angiogenesis, inflammation, peritumoral edema, migration, and invasion. Furthermore, this diet can enhance the activity of radiation and chemotherapy in a mouse model of glioma, thus increasing survival. In vitro studies indicate that increasing ketones in the absence of glucose reduction can also inhibit cell growth and potentiate the effects of radiation. Thus, emerging data provide strong support for the use of KD in the treatment of malignant gliomas and thus far has led to a limited number of clinical trials.
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10

E, Sobel Burton, and Collen D, eds. Coronary thrombolysis in perspective: Principles underlying conjunctive and adjunctive therapy. New York: M.Dekker, 1993.

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11

David, Hailey, and Canadian Agency for Drugs and Technologies in Health., eds. Adjunctive hyperbaric oxygen therapy for diabetic foot ulcer: An economic analysis. Ottawa: Canadian Agency for Drugs and Technologies in Health, 2007.

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12

J, Beuth, Moss Ralph W, and Abel Ulrich 1952-, eds. Complementary oncology: Adjunctive methods in the treatment of cancer. Stuttgart: Thieme, 2006.

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13

Baar, Bruce. Electrical Immune Therapy and Multiple Sclerosis: An Adjunctive Therapy Using the Baar Wet Cell Battery and Vibradex Solutions. Independently Published, 2019.

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14

Bates, Eric R. Thrombolysis and Adjunctive Therapy for Acute Myocardial Infarction (Fundamental and Clinical Cardiology, Vol 10). Informa Healthcare, 1992.

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15

(Editor), William O'Donohue, and Nicholas A. Cummings (Editor), eds. Evidence-Based Adjunctive Treatments (Practical Resources for the Mental Health Professional). Academic Press, 2008.

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16

De Aquino, João Paulo, and Robert Beech. Mood Stabilizer Monotherapy versus Adjunctive Antidepressant for Bipolar Depression. Edited by Ish P. Bhalla, Rajesh R. Tampi, Vinod H. Srihari, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190625085.003.0004.

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This chapter provides a summary of a landmark study on bipolar disorder, which aims to address the following question: In patients with bipolar disorder receiving mood-stabilizing agents, does adjunctive antidepressant therapy reduce the symptoms of bipolar depression without increasing the risk for mania? Starting with that question, the chapter describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints and results, in addition criticisms and limitations. Subsequently, other relevant studies are briefly reviewed and their clinical implications are discussed. Finally, a relevant clinical exemplifies the application of the current evidence behind the clinical question addressed by the study.
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17

Sobel, Burton E. Coronary Thrombosis in Perspective: Principles Underlying Conjunctive and Adjunctive Therapy (Fundamental and Clinical Cardiology, Vol 16). Marcel Dekker, 1993.

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18

Reinares, María. Psychotherapeutic interventions for bipolar disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0012.

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The recurrent nature of bipolar disorder (BD), and the high morbidity and mortality associated with the illness advocate for an integrative treatment in which medication is complemented with psychological approaches. This chapter explores the role of adjunctive psychotherapy in BD. The most commonly tested psychological treatments have been cognitive-behavioural therapy, psychoeducation, interpersonal and social rhythm therapy, and family intervention. Functional remediation represents a new option for patients with functional impairment. Most findings indicate the benefits of adjunctive psychological treatments to improve the outcomes of BD. Controversial results have also been found, highlighting the need for a better identification of treatment moderators and mediators to design interventions tailored to the target population. Recently, cognitive remediation, mindfulness-based cognitive therapy, dialectical behaviour therapy, and eye movement desensitization and reprocessing have begun to be tested, as well as Internet-based psychological interventions, but it is too early to draw conclusions about their efficacy.
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19

Covert, Bryan, and Marc A. Huntoon. Neuromodulation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190217518.003.0010.

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This chapter addresses the indications for and complications related to surgical, pharmacologic, and adjunctive neuromodulation therapy. Many forms of neuromodulation therapy find their inspiration from the landmark work by Melzack and Wall in 1965 that described the gate theory of pain. Fifty years later, technological and pharmaceutical progress leads the charge on this exciting field within pain medicine. As understanding of the generation, transmission, and interpretation of pain signaling expands, the options for interventional and medical therapy will surely follow suit. These advancements are a welcome addition as the aging population meets a medical community seeking to curb chronic opioid therapy. The questions in this chapter serve as a guide to the salient neuromodulation techniques, but an emphasis should be placed on the suggested readings in this chapter to develop a more thorough understanding of the topic and variety of techniques and pharmacotherapy not covered.
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20

Feldman, Talya, Cristin D. Runfola, and James Lock. Feeding and Eating Disorders. Edited by Thomas H. Ollendick, Susan W. White, and Bradley A. White. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190634841.013.23.

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Eating disorders are severe, life-threatening psychological disorders that frequently manifest in children and adolescents. This chapter provides an overview of the prevalence, epidemiology, assessment, and treatment of the six child and adolescent feeding and eating disorders covered by the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders: pica, rumination disorder, avoidant/restrictive food intake disorder, anorexia nervosa, bulimia nervosa, binge-eating disorder, and other specified feeding or eating disorder. Existing research is limited, but the most evidenced treatments, depending on disorder, are applied behavioral analysis; individualized behavior plans; family-based therapy; cognitive behavioral therapy; and self-help. Given the limited number of randomized controlled studies and the moderate (at best) recovery rates, future research should investigate possible adjunctive treatments (i.e., cognitive remediation therapy, dialectical behavior therapy); adaptations for specific populations; and dissemination and implementation improvements (i.e., phone or Internet delivered interventions).
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21

Muralidharan, Anjana, David J. Miklowitz, and W. Edward Craighead. Psychosocial Treatments for Bipolar Disorder. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0010.

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Pharmacological interventions remain the primary treatment for bipolar disorder. However, adjunctive psychosocial interventions have the potential to increase adherence to medication regimens, decrease hospitalizations and relapses, decrease severity of symptoms, improve quality of life, and enhance mechanisms for coping with stress. Group psychoeducation, designed to provide information to bipolar patients about the disorder and its treatment, leads to lower rates of recurrence and greater adherence to medication among remitted bipolar patients at both short- and long-term follow-up. Cognitive-behavioral therapy as an ancillary treatment has found mixed results but generally supportive evidence indicating that it is useful in preventing relapse to depression in remitted patients. Family-based intervention, such as Family-Focused Therapy (FFT), may be combined with pharmacotherapy to reduce recurrences and hospitalization rates in adult patients.
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22

Kittel-Schneider, Sarah. The treatment of bipolar mixed states. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0005.

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Definition of mixed episodes has changed in the Diagnostic and Statistical Manual of Mental Disorders (5th edition) (DSM-5). A mixed feature specifier can be added not only to major depressive episodes and manic episodes in bipolar patients but also to hypomanic episodes in bipolar II patients and major depressive episode in major depressive disorder. Atypical antipsychotics seem to be effective in acute treatment as well as valproate and carbamazepine. Regarding prophylaxis of mixed states, monotherapy with valproate, olanzapine and quetiapine seems to prevent mixed episodes. Adjunctive therapy with valproate or lithium to quetiapine has also proven to be effective in prophylaxis of mixed episodes. In patients who suffer from pharmacotherapy-resistant mixed episodes electroconvulsive therapy can lead to response/remission. There is a lack of randomized controlled clinical trials investigating pharmacological and non-pharmacological treatments with focus on mixed states of bipolar patients, especially according to the DSM-5 definition.
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23

Kahn, S. Lowell. Balloon-Assisted Thrombin Injection for Pseudoaneurysms with Wide or Short Neck Morphology. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0021.

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Pseudoaneurysms after cardiac catheterizations are not uncommon. Although most commonly they occur superficial to the common femoral artery, they are reported to occur at any location intentionally or unintentionally accessed. Ultrasound-assisted thrombin injection is a mainstay of therapy in appropriate patients. Although variations exist regarding the optimal location and amount of thrombin injection, the superior outcomes, low complication rate, and low cost associated with this method render great appeal to its utilization. This chapter describes an adjunctive technique (as well as a simple modification) to prevent the entrance of thrombin to the vasculature using a balloon to isolate the pseudoaneurysm. Although typically not necessary, this technique is valuable in the treatment of high-risk pseudoaneurysms and is well described in the literature.
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24

Patel, Mayur B., and Pratik P. Pandharipande. Analgesics in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0043.

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Analgesia is a critical component of intensive care unit (ICU) care. Accordingly, understanding the mechanism, physiological consequences, and assessment of pain is important when caring for the ICU patient. Non-pharmacological approaches should be attempted before supplementing analgesia with pharmacological agents. Pharmacologically-based therapies are divided into regional and systemic therapies. Regional analgesic therapies target specific areas of the body while limiting the systemic effects of intravenous analgesics, but at the risk of invasiveness, local anaesthetic toxicity, and infection of in-dwelling catheters. Systemic analgesic therapy is comprised of two main categories—non-opioids and opioids. Typically, non-opioid analgesics are used as adjunctive therapies and consist of agents such as non-steroidal anti-inflammatory drugs, gabapentinoids, ketamine, or α‎2 agonists. Opioid analgesia in the ICU is commonly infusion-based using fentanyl, hydromorphone, morphine, or recently, remifentanil.
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25

Karpova, Nina N. Pharmacological Adjuncts and Evidence-Supported Treatments for Trauma. Edited by Sara Maltzman. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199739134.013.32.

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A large proportion of humans experienced a traumatic event in their lifetime, with more than 10% developing posttraumatic stress disorder (PTSD), panic disorder, phobias, and other fear/anxiety disorders. The neural circuitry of fear responses is highly conserved in humans as well as rodents, and this allows for translational research using animal models of fear. Fear/anxiety disorders in humans are most efficiently treated by exposure-based psychotherapy (i.e., cognitive behavioral therapy; CBT), the main aspects of which are closely modeled by extinction training in Pavlovian fear conditioning and extinction paradigms in rodents. To improve the efficacy of psychotherapy, pharmacological agents potent for enhancing learning and memory consolidation processing should be developed to combine with exposure-based therapy. The purpose of these adjunctive pharmacological agents is to promote fear memory erasure and the consolidation of extinction memories, thus providing a combined treatment of increased effectiveness. This review discusses established pharmacological adjuncts to behavioral therapeutic interventions for fear/anxiety disorders. The mechanisms of action of these adjuncts, as well as the evidence for and against the pharmacological treatment strategies and their limitations are discussed.
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26

Morrison, Mary F., Karen Lin, and Susan Gersh. Addictions: Evidence for Integrative Treatment. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0021.

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Legal and illicit substance use disorders are common conditions associated with substantial impairment in health as well as social and occupational functioning. Integrative medicine proposes modalities that offer promise for increasing the likelihood of undertaking treatment for substance use as well as retaining individuals in treatment. Of the integrative therapies discussed, mindfulness-based therapies have both the greatest number of and most rigorous studies for substance use disorders. Mindfulness-based therapies can significantly reduce the consumption of tobacco, alcohol, and other substances compared to control conditions. Complementary therapies reviewed include acupuncture, mindfulness-based practices, exercise, yoga, biofeedback and neurofeedback, art and music therapy, as well as diet and dietary supplements, both herbal and vitamin. Given the high acceptability and low cost of integrative medicine interventions, studies employing these techniques as adjunctive therapies to conventional treatments should be more vigorously supported if they are well-designed and include adequate numbers of subjects.
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27

Cooper, Mark S. Hormone therapies in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0049.

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A range of hormonal manipulations have been proposed as adjunctive therapy during critical care. These therapies might be used to treat a pre-existing or acquired hormonal disorder. Additionally, hormonal manipulation has been suggested to alter the long-term outcome of critical illness, even in patients without structural abnormalities of endocrine glands. Currently, the effectiveness of these anabolic therapies has not been established and they might be harmful in some patient groups. Recently, it has been recognized that many critically-ill patients have low levels of vitamin D and this is associated with an adverse outcome. It is still unclear whether replacement of vitamin D will be effective in improving outcome. This chapter will also highlight the importance of recognizing and addressing hormonal deficiency in patients with known pituitary disease and with traumatic brain injury (TBI). TBI is associated with a high prevalence of acute and long-term pituitary dysfunction. The management of the rare, but important thyroid disorders requiring critical care, thyroid storm, and myxoedema coma, will also be discussed.
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28

Ohkawa, Reiko. Psycho-oncology: the sexuality of women and cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198749547.003.0011.

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Female patients undergoing treatment for cancer often experience significant changes in their sexuality due to the disease and its treatment. Sexuality relates to the sexual habits and desires of each individual. It varies according to age-related sexual needs. Many women with cancer consider their sexuality an important aspect of their lives. Yet, they may refrain from sex or enjoy it less following treatment, whether it be surgical or by irradiation, and accompanied by adjunctive chemotherapy or hormonal therapy. Chapter 11 discusses these issues, with a vignette illustrating the impact of an unexpected diagnosis of cancer. Multiple studies have examined sexual dysfunction following treatment of gynaecological cancers, including breast cancer, and several proposed solutions are available. However, the information has not been implemented by many health providers, and patients often experience anxiety and embarrassment when planning to discuss sexuality. The patients may be concerned that their sexual habits might interfere with the treatment outcome, and cause a recurrence of cancer. Reproductive dysfunction is only one of the manifold problems in the female undergoing cancer therapy. It can lead to infertility but certain treatment methods could help retain fertility. Ethical concerns pertaining to the preservation, and use of germ cells, need to be addressed. Ideally, a team of healthcare providers should handle sexual rehabilitation of the cancer survivor based on the patient's history. Unfamiliarity with such matters makes many medical professionals hesitant in discussing their patients' sexuality. The PLISSIT model can help initiate the assessment of sexual dysfunction in these patients.
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29

Mesquita, Emersom C., and Fernando A. Bozza. Diagnosis and management of viral haemorrhagic fevers in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0293.

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In a globalized scenario where widespread international travel allows viral agents to migrate from endemic to non-endemic areas, health care providers and critical care specialists must be able to readily recognize a suspected case of viral haemorrhagic fever (VHF). Early suspicion is pivotal for improving patient outcome and to ensure that appropriate biosafety measures be applied. VHFs are acute febrile illnesses marked by coagulation disorders and organ specific syndromes. VHFs represent a great medical challenge because diseases are associated with a high mortality rate and many VHFs have the potential for person-to-person transmission (Filoviruses, Arenavioruses, and Bunyaviroses). Dengue is the most frequent haemorrhagic viral disease and re-emergent infection in the world and, due to its public health relevance, severe dengue will receive special attention in this chapter. The diagnosis of VHFs is made by detecting specific antibodies, viral antigens (ELISA) and viral nucleic acid (RT-PCR) on blood samples. Supportive care is the cornerstone in the treatment of VHFs. Ribavirin should be started as soon as a case of VHF is suspected and discontinued if a diagnosis of Filovirus or Flavivirus infection is established. Adjunctive antimicrobial therapy is usually implemented to treat co-existing or secondary infections. Antimalarial treatment should also be initiated if a malaria test (thick blood films) is not quickly available and/or reliable and patients travel history is compatible. It is always recommended to apply appropriate biosafety measures and notify local infection control unit and state and national authorities.
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