Relevant bibliographies by topics / ADH-1

Academic literature on the topic 'ADH-1'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "ADH-1"

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Lin, Guang-Huey, Ming-Chuan Hsieh, and Hung-Yu Shu. "Role of Iron-Containing Alcohol Dehydrogenases in Acinetobacter baumannii ATCC 19606 Stress Resistance and Virulence." International Journal of Molecular Sciences 22, no. 18 (September 14, 2021): 9921. http://dx.doi.org/10.3390/ijms22189921.

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Most bacteria possess alcohol dehydrogenase (ADH) genes (Adh genes) to mitigate alcohol toxicity, but these genes have functions beyond alcohol degradation. Previous research has shown that ADH can modulate quorum sensing in Acinetobacter baumannii, a rising opportunistic pathogen. However, the number and nature of Adh genes in A. baumannii have not yet been fully characterized. We identified seven alcohol dehydrogenases (NAD+-ADHs) from A. baumannii ATCC 19606, and examined the roles of three iron-containing ADHs, ADH3, ADH4, and ADH6. Marker-less mutation was used to generate Adh3, Adh4, and Adh6 single, double, and triple mutants. Disrupted Adh4 mutants failed to grow in ethanol-, 1-butanol-, or 1-propanol-containing mediums, and recombinant ADH4 exhibited strongest activity against ethanol. Stress resistance assays with inorganic and organic hydroperoxides showed that Adh3 and Adh6 were key to oxidative stress resistance. Virulence assays performed on the Galleria mellonella model organism revealed that Adh4 mutants had comparable virulence to wild-type, while Adh3 and Adh6 mutants had reduced virulence. The results suggest that ADH4 is primarily involved in alcohol metabolism, while ADH3 and ADH6 are key to stress resistance and virulence. Further investigation into the roles of other ADHs in A. baumannii is warranted.
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&NA;. "ADH 1." Reactions Weekly &NA;, no. 1389 (February 2012): 7. http://dx.doi.org/10.2165/00128415-201213890-00018.

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van Ooij, C., R. C. Snyder, B. W. Paeper, and G. Duester. "Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein." Molecular and Cellular Biology 12, no. 7 (July 1992): 3023–31. http://dx.doi.org/10.1128/mcb.12.7.3023-3031.1992.

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The human class I alcohol dehydrogenase (ADH) gene family consists of ADH1, ADH2, and ADH3, which are sequentially activated in early fetal, late fetal, and postnatal liver, respectively. Analysis of ADH promoters revealed differential activation by several factors previously shown to control liver transcription. In cotransfection assays, the ADH1 promoter, but not the ADH2 or ADH3 promoter, was shown to respond to hepatocyte nuclear factor 1 (HNF-1), which has previously been shown to regulate transcription in early liver development. The ADH2 promoter, but not the ADH1 or ADH3 promoter, was shown to respond to CCAAT/enhancer-binding protein alpha (C/EBP alpha), a transcription factor particularly active during late fetal liver and early postnatal liver development. The ADH1, ADH2, and ADH3 promoters all responded to the liver transcription factors liver activator protein (LAP) and D-element-binding protein (DBP), which are most active in postnatal liver. For all three promoters, the activation by LAP or DBP was higher than that seen by HNF-1 or C/EBP alpha, and a significant synergism between C/EBP alpha and LAP was noticed for the ADH2 and ADH3 promoters when both factors were simultaneously cotransfected. A hierarchy of ADH promoter responsiveness to C/EBP alpha and LAP homo- and heterodimers is suggested. In all three ADH genes, LAP bound to the same four sites previously reported for C/EBP alpha (i.e., -160, -120, -40, and -20 bp), but DBP bound strongly only to the site located at -40 bp relative to the transcriptional start. Mutational analysis of ADH2 indicated that the -40 bp element accounts for most of the promoter regulation by the bZIP factors analyzed. These studies suggest that HNF-1 and C/EBP alpha help establish ADH gene family transcription in fetal liver and that LAP and DBP help maintain high-level ADH gene family transcription in postnatal liver.
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van Ooij, C., R. C. Snyder, B. W. Paeper, and G. Duester. "Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein." Molecular and Cellular Biology 12, no. 7 (July 1992): 3023–31. http://dx.doi.org/10.1128/mcb.12.7.3023.

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The human class I alcohol dehydrogenase (ADH) gene family consists of ADH1, ADH2, and ADH3, which are sequentially activated in early fetal, late fetal, and postnatal liver, respectively. Analysis of ADH promoters revealed differential activation by several factors previously shown to control liver transcription. In cotransfection assays, the ADH1 promoter, but not the ADH2 or ADH3 promoter, was shown to respond to hepatocyte nuclear factor 1 (HNF-1), which has previously been shown to regulate transcription in early liver development. The ADH2 promoter, but not the ADH1 or ADH3 promoter, was shown to respond to CCAAT/enhancer-binding protein alpha (C/EBP alpha), a transcription factor particularly active during late fetal liver and early postnatal liver development. The ADH1, ADH2, and ADH3 promoters all responded to the liver transcription factors liver activator protein (LAP) and D-element-binding protein (DBP), which are most active in postnatal liver. For all three promoters, the activation by LAP or DBP was higher than that seen by HNF-1 or C/EBP alpha, and a significant synergism between C/EBP alpha and LAP was noticed for the ADH2 and ADH3 promoters when both factors were simultaneously cotransfected. A hierarchy of ADH promoter responsiveness to C/EBP alpha and LAP homo- and heterodimers is suggested. In all three ADH genes, LAP bound to the same four sites previously reported for C/EBP alpha (i.e., -160, -120, -40, and -20 bp), but DBP bound strongly only to the site located at -40 bp relative to the transcriptional start. Mutational analysis of ADH2 indicated that the -40 bp element accounts for most of the promoter regulation by the bZIP factors analyzed. These studies suggest that HNF-1 and C/EBP alpha help establish ADH gene family transcription in fetal liver and that LAP and DBP help maintain high-level ADH gene family transcription in postnatal liver.
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Liu, Xueqian, Yanpeng Dong, Jing Zhang, Aixiang Zhang, Lei Wang, and Lu Feng. "Two novel metal-independent long-chain alkyl alcohol dehydrogenases from Geobacillus thermodenitrificans NG80-2." Microbiology 155, no. 6 (June 1, 2009): 2078–85. http://dx.doi.org/10.1099/mic.0.027201-0.

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Two alkyl alcohol dehydrogenase (ADH) genes from the long-chain alkane-degrading strain Geobacillus thermodenitrificans NG80-2 were characterized in vitro. ADH1 and ADH2 were prepared heterologously in Escherichia coli as a homooctameric and a homodimeric protein, respectively. Both ADHs can oxidize a broad range of alkyl alcohols up to at least C30, as well as 1,3-propanediol and acetaldehyde. ADH1 also oxidizes glycerol, and ADH2 oxidizes isopropyl alcohol, isoamylol, acetone, octanal and decanal. The best substrate is ethanol for ADH1 and 1-octanol for ADH2. For both ADHs, the optimum assay condition is at 60 °C and pH 8.0, and both NAD and NADP can be used as the cofactor. Sequence analysis reveals that ADH1 and ADH2 belong to the Fe-containing/activated long-chain ADHs. However, the two enzymes contain neither Fe nor other metals, and Fe is not required for the activity, suggesting a new type of ADH. The ADHs characterized here are potentially useful in crude oil bioremediation and other bioconversion processes.
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Mangum, Paul D., and Ellen B. Peffley. "INHERITANCE OF PGM-1, ADH-1, AND 6-PGDH-1 in ALLIUM FISTULOSUM L." HortScience 27, no. 6 (June 1992): 644d—644. http://dx.doi.org/10.21273/hortsci.27.6.644d.

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The inheritance and linkage relationships among PGM-1, ADH-1, and 6-PGDH-1 were determined for Allium fistulosum (Japanese bunching onion) individuals. Individuals expressing Pgm-11/Pgm-12, Adh-13/Adh-14, Adh-13/Adh-15, or 6-Pgdh-11/6-Pgdh-12 were selfed seperately. These backcrosses and their reciprocals were made: Pgm-11/Pgm-12 to Pgm-11/Pgm-11 or Pgm-12/Pgm-12; Adh-13/Adh-14 to Adh-13/Adh-13 or Adh-14/Adh-14, 6-Pgdh-11/6-Pgdh-12 to 6-Pgdh-11/6-Pgdh-11 or 6-Pgdh-12/6-Pgdh-12. Progeny segregations were tested for Mendelian inheritance using a chi-square goodness of fit test. Expression of 6-Pgdh has not been previously reported in onion. Two zones of activity were detected and were designated as 6-PGDH-1 and 6-PGDH-2. 6-PGDH-2 was monomorphic for all individuals tested. Progeny segregation of 6-PGDH-1 fit a model for a dimeric enzyme encoded by one disomic locus with two alleles, expressed as fast (1) and slow (2), in a dimeric enzyme pattern in heterozygous individuals.
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Haseba, Takeshi, Kouji Kameyama, Keiko Mashimo, and Youkichi Ohno. "Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse." International Journal of Hepatology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/408190.

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ADH 1 and ADH 3 are major two ADH isozymes in the liver, which participate in systemic alcohol metabolism, mainly distributing in parenchymal and in sinusoidal endothelial cells of the liver, respectively. We investigated how these two ADHs contribute to the elimination kinetics of blood ethanol by administering ethanol to mice at various doses, and by measuring liver ADH activity and liver contents of both ADHs. The normalized AUC (AUC/dose) showed a concave increase with an increase in ethanol dose, inversely correlating with β.CLT(dose/AUC) linearly correlated with liver ADH activity and also with both the ADH-1 and -3 contents (mg/kg B.W.). When ADH-1 activity was calculated by multiplying ADH-1 content by itsVmax⁡/mg (4.0) and normalized by the ratio of liver ADH activity of each ethanol dose to that of the control, the theoretical ADH-1 activity decreased dose-dependently, correlating with β. On the other hand, the theoretical ADH-3 activity, which was calculated by subtracting ADH-1 activity from liver ADH activity and normalized, increased dose-dependently, correlating with the normalized AUC. These results suggested that the elimination kinetics of blood ethanol in mice was dose-dependently changed, accompanied by a shift of the dominant metabolizing enzyme from ADH 1 to ADH 3.
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Haseba, Takeshi, Takahisa Okuda, Motoyo Maruyama, Toshio Akimoto, Gregg Duester, and Youkichi Ohno. "Roles of Two Major Alcohol Dehydrogenases, ADH1 (Class I) and ADH3 (Class III), in the Adaptive Enhancement of Alcohol Metabolism Induced by Chronic Alcohol Consumption in Mice." Alcohol and Alcoholism 55, no. 1 (December 11, 2019): 11–19. http://dx.doi.org/10.1093/alcalc/agz091.

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Abstract Aims It is still unclear which enzymes contribute to the adaptive enhancement of alcohol metabolism by chronic alcohol consumption (CAC). ADH1 (Class I) has the lowest Km for ethanol and the highest sensitivity for 4-methylpyrazole (4MP) among ADH isozymes, while ADH3 (Class III) has the highest Km and the lowest sensitivity. We investigated how these two major ADHs relate to the adaptive enhancement of alcohol metabolism. Methods Male mice with different ADH genotypes (WT, Adh1−/− and Adh3−/−) were subjected to CAC experiment using a 10% ethanol solution for 1 month. Alcohol elimination rate (AER) was measured after ethanol injection at a 4.0 g/kg dose. 4MP-sensitive and -insensitive AERs were measured by the simultaneous administration of 4MP at a dose of 0.5 mmol/kg in order to estimate ADH1 and non-ADH1 pathways. Results AER was enhanced by CAC in all ADH genotypes, especially more than twofold in Adh1−/− mice, with increasing ADH1 and/or ADH3 liver contents, but not CYP2E1 content. 4MP-sensitive AER was also increased by CAC in WT and Adh3−/− strains, which was greater in Adh3−/− than in WT mice. The sensitive AER was increased even in Adh1−/− mice probably due to the increase in ADH3, which is semi-sensitive for 4MP. 4MP-insensitive AER was also increased in WT and Adh1−/− by CAC, but not in Adh3−/− mice. Conclusion ADH1 contributes to the enhancement of alcohol metabolism by CAC, particularly in the absence of ADH3. ADH3 also contributes to the enhancement as a non-ADH1 pathway, especially in the absence of ADH1.
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Mitchell, L. E., E. S. Dennis, and W. J. Peacock. "Molecular analysis of an alcohol dehydrogenase (Adh) gene from chromosome 1 of wheat." Genome 32, no. 3 (June 1, 1989): 349–58. http://dx.doi.org/10.1139/g89-454.

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We have cloned and determined the nucleotide sequence of a gene encoding alcohol dehydrogenase (Adh) from Triticum aestivum cv. Millewa. Southern analysis using cv. Chinese Spring nullisomic–tetrasomic and ditelosomic lines established that the cloned gene mapped to the long arm of chromosome 1A and does not correspond to any previously identified wheat Adh locus. Southern analysis also provided evidence for triplicate copies of this Adh gene on the homoeologous group 1 chromosomes, while Northern blots indicated that the homoeologous group 1 Adh genes, like several other plant Adh genes, are transcribed under anaerobic conditions. Sequence analysis indicates that the cloned gene has a structure similar to both monocot and dicot Adh genes with an open reading frame encoding a polypeptide of 379 amino acids. Sequences important for eucaryotic gene expression such as the TATA box, polyadenylation signal, and intron splice sites were found in the expected positions. The open reading frame is interrupted by 8 introns which are in identical positions with 8 of the 9 introns in maize and pea Adh genes, suggesting that during evolution there are processes occurring that result in the loss of introns. Sequence analysis also revealed that the cloned wheat Adh gene shared extensive homology with the barley Adh3 gene not only in the coding region but also in the noncoding regions. However, this homology is discontinuous as a result of a 1.8-kbp insertion (TLM), which is present in the cloned wheat Adh gene and absent in the barley Adh3 gene. Sequence analysis of this insertion reveals features characteristic of the short terminal inverted repeat class of eucaryotic transposable elements. We have no evidence for the transposition of the TLM element. However, Southern blots reveal multiple copies of sequences related to TLM in the wheat genome and in other closely related species, suggesting that transposition may once have played an important role in the evolution of the Gramineae family.Key words: Triticum aestivum, alcohol dehydrogenase, Adh, chromosome 1, anaerobic induction, insertion element, transposable element.
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Ayer, S., and C. Benyajati. "Conserved enhancer and silencer elements responsible for differential Adh transcription in Drosophila cell lines." Molecular and Cellular Biology 10, no. 7 (July 1990): 3512–23. http://dx.doi.org/10.1128/mcb.10.7.3512-3523.1990.

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The distal promoter of Adh is differentially expressed in Drosophila tissue culture cell lines. After transfection with an exogenous Adh gene, there was a specific increase in distal alcohol dehydrogenase (ADH) transcripts in ADH-expressing (ADH+) cells above the levels observed in transfected ADH-nonexpressing (ADH-) cells. We used deletion mutations and a comparative transient-expression assay to identify the cis-acting elements responsible for enhanced Adh distal transcription in ADH+ cells. DNA sequences controlling high levels of distal transcription were localized to a 15-base-pair (bp) region nearly 500 bp upstream of the distal RNA start site. In addition, a 61-bp negative cis-acting element was found upstream from and adjacent to the enhancer. When this silencer element was deleted, distal transcription increased only in the ADH+ cell line. These distant upstream elements must interact with the promoter elements, the Adf-1-binding site and the TATA box, as they only influenced transcription when at least one of these two positive distal promoter elements was present. Internal deletions targeted to the Adf-1-binding site or the TATA box reduced transcription in both cell types but did not affect the transcription initiation site. Distal transcription in transfected ADH- cells appears to be controlled primarily through these promoter elements and does not involve the upstream regulatory elements. Evolutionary conservation in distantly related Drosophila species suggests the importance of these upstream elements in correct developmental and tissue-specific expression of ADH.
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Dissertations / Theses on the topic "ADH-1"

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Meyer, Arnd. "Programmbeschreibung SPC-PM3-AdH-XX - Teil 1." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-136749.

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Beschreibung der Finite Elemente Software-Familie SPC-PM3-AdH-XX für: (S)cientific (P)arallel (C)omputing - (P)rogramm-(M)odul (3)D (ad)aptiv (H)exaederelemente. Für XX stehen die einzelnen Spezialvarianten, die in Teil 2 detailliert geschildert werden. Stand: Ende 2013
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Turcinelli, Silvia Regina. "Caracterização molecular de um mutante para o gene Adh - 1 identificado em um variante somacional de milho." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316405.

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Orientador: Adilson Leite
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-07-21T19:39:01Z (GMT). No. of bitstreams: 1 Turcinelli_SilviaRegina_M.pdf: 5122448 bytes, checksum: f181f23e777e96ab7baab2729be3de58 (MD5) Previous issue date: 1996
Mestrado
Genetica
Mestre em Ciências Biológicas
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Berelov, Ilya. "Occupation and abandonment of Middle Bronze Age Zahrat adh-Dhra' 1, Jordan the behavioural implications of quantitative ceramic analyses /." Oxford (England) : Archaeopress, 2006. http://catalogue.bnf.fr/ark:/12148/cb40157593k.

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Quaresma, Ana Cristina de Azevedo. "Isolamento e modificação de xilanas da pasta branca." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13274.

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Mestrado em Engenharia Química
A remoção de xilanas na pasta branca kraft pode ser uma prática convencional para a produção de materiais celulósicos para uso não papeleiros, tais como derivados de celulose, celulose microfibrilada, entre outros. As xilanas têm uma ampla gama de aplicações nas indústrias farmacêuticas, papeleiras e alimentares. Na indústria da pasta e papel, a xilana pode ser utilizada como revestimento dos papéis substituindo polissacarídeos utilizados normalmente, como o amido. Para a aplicação das xilanas nesta área, a sua massa molecular tem de ser muito superior à das xilanas existentes na pasta celulósica, pelo menos 50 𝑘𝐷𝑎. O objetivo deste trabalho consiste no estudo da possibilidade de extração e isolamento de xilanas de pasta branca kraft de eucalipto, elucidar a possibilidade de aumento do peso molecular das mesmas para posterior utilização na indústria papeleira. A xilana foi extraída com soluções aquosas de NaOH a 10% durante 1 hora, sendo posteriormente acidificada e isolada sob a forma de precipitado. Aditivamente, as xilanas foram purificadas por diálise contra água destilada. As xilanas obtidas foram caracterizadas por teor de cinzas, composição de açúcares, estrutura e peso molecular. O teor de cinzas foi avaliado recorrendo ao método termogravimetrico, a análise de açúcares por cromatografia gasosa com alditol-acetato, a estrutura da xilana foi elucidada recorrendo às técnicas de 1H RMN e 13C RMN em estado sólido e o peso molecular foi utilizada a técnica de cromatografia por permeação de gel. Os resultados obtidos demonstraram que as xilanas não purificadas apresentam teor de cinzas elevado (55−81%), o peso molecular médio ponderal das xilanas extraídas estavam compreendidos no intervalo dos 26,3 – 28,2 kDa. Pela análise dos monossacarídeos e 1H RMN podemos concluir que as xilanas isoladas são 2−𝑂−metil−𝛼−𝐷− glucurono − 𝐷− xilanas. A modificação das xilanas foi efetuada utilizando os métodos de bioconjugação em soluções aquosas num sistema acidificado de ADH na presença de EDC e através de derivados de metilol em dimetilsulfóxido. Os produtos derivatizados foram caracterizados por teor de cinzas, estrutura e peso molecular. O teor de cinzas foi avaliado recorrendo ao método termogravimetrico, a estrutura da xilana foi elucidada recorrendo às técnicas de FTIR, 1H RMN e 13C RMN em estado sólido e a massa molecular foi utilizada a técnica de cromatografia por permeação de gel. O peso molecular médio ponderal através do método de bioconjugação chegou quase aos valores desejados para este tipo de compostos.
The removal of xylan in kraft bleached pulp can be a conventional practice for the production of non-cellulosic materials papermakers use, such as cellulose derivatives, microfibrillated cellulose, among others. The xylan have a wide range of applications in the pharmaceutical, paper and food industries. In the pulp and paper industry, the xylan can be used to coat papers replacing normally used polysaccharides such as starch. For the application of xylan in this area, its molecular weight must be much higher than the existing xylan in pulp, at least 50 kDa. The objective of this work is to study the possibility of extraction and isolation of xylan from kraft bleached eucalyptus pulp, to elucidate the possibility of increasing the molecular weight of these for later use in the paper industry. Xylan was extracted with aqueous solution of NaOH 10% for 1 hour and subsequently acidified and isolated in the form of precipitate. Additively, the xylan were purified by dialysis against distilled water. The xylan obtained were characterized by ash content, sugar composition, structure and molecular weight. The ash content was evaluated using the thermogravimetric method, the analysis of sugars by gas chromatography with alditol acetate, the structure of xylan was elucidated using techniques 1H NMR and solid state 13C NMR and for molecular mass was used chromatography technique. The results showed that the non-purified xylan show a high ash content (55-81%), the weight average molecular weight of the extracted xylan were in the range of 26.3 to 28.2 kDa. Form the analysis of monosaccharides and 1H NMR we can conclude that isolated xylans are 2-O-methyl-α-D-glucurono - D-xylan. The modification of xylan was carried out using the methods of bioconjugation in aqueous solutions in a acidified system with ADH in the presence of EDC and via methylol derivatives in dimethylsulphoxide solutions. The derivatized products were characterized by ash content, structure and molecular weight. The ash content was evaluated using the thermogravimetric method, the xylan structure was elucidated using FTIR techniques, 1H NMR and 13C NMR in solid form and the technique of molecular weight by gel permeation chromatography was employed. The average molecular weight of the compounds obtained by the method of bioconjugation reached almost the desired values.
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Calvert, Charlene. "Arabidopsis poly (ADP-ribose) polymerase-1 (AtPARP-1) and resistance to genotoxic stress." Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426681.

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Scarinci, Carlos. "The phase space of 2+1 AdS gravity." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12814/.

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We describe what can be called the “universal” phase space of 2+1 AdS gravity, in which the moduli spaces of globally hyperbolic AdS spacetimes with compact Cauchy surface, as well as the moduli spaces of multi black hole spacetimes are realized as submanifolds. Importantly our phase space also includes all Brown-Henneaux excitations on the conformal boundary of asymptotically AdS spacetimes, with Diff+(S1)/SL(2,R)xDiff+(S1)/SL(2,R) contained as a submanifold. Our description of the universal phase space is obtained from results on the correspondence between maximal surfaces in AdS3 and quasi-symmetric homeomorphisms of the unit circle. We find that the phase space can be parametrized by two copies of the universal Teichmuller space T(D), or equivalently by the cotangent bundle over T(D). This yields a symplectic map from T*T(D) to T(D)xT(D) generalizing the well-known Mess map in the compact spatial surface setting. We also relate our parametrization to the Chern-Simons formulation of 2+1 gravity and, infinitesimally, to the holographic (Fefferman-Graham) description. In particular, we relate the charges arising in the holographic description (such as the mass and angular momentum of asymptotically AdS spacetimes) to the periods of holomorphic quadratic differentials arising via the Bers embedding of T(D)xT(D).
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Kandan-Kulangara, Febitha. "Poly(ADP-ribose) polymerase-1 (PARP-1) and RNA interference (RNAI) during cell death." Doctoral thesis, Université Laval, 2013. http://hdl.handle.net/20.500.11794/25972.

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L’activation de la poly(ADP-ribose) polymérase-1 (PARP-1) en réponse aux dommages à l’ADN est impliquée dans diverses réponses cellulaires, de la réparation de l’ADN à la mort cellulaire. Dans l'annexe I, nous avons décrit différentes techniques indispensables pour détecter le métabolisme de PARP-1 en réponse aux dommages à l’ADN in vitro et in vivo. Les travaux de cette thèse se concentrent sur le rôle de PARP-1 dans la mort cellulaire. PARP-1 est clivée et inactivée par des caspases pendant l’apoptose ; j’ai donc utilisé une PARP-1 non-clivable pour étudier le rôle de l’activation et de la fragmentation de PARP-1 dans la mort cellulaire induite par les UVB. Nous avons observé que, contrairement aux fibroblastes de peau humaine exprimant la PARP-1, les fibroblastes avec un "knockdown" de PARP-1 sont résistants à l’apoptose induite par les UVB, phénotype pouvant être totalement inversé par ré-expression de PARP-1 sauvage mais pas de PARP-1 non-clivable par les caspases, suggérant un rôle significatif du clivage de PARP-1 en réponse à la mort cellulaire induite par les UVB (chapitre 2). Dans ce contexte, nous avons récemment passé en revue comment les substrats non clivables par des caspases peuvent être utilisés comme outil important pour démystifier le rôle de ce clivage pour la mort comme pour la vie, avec l’exemple spécifique de PARP-1 non-clivable par les caspases (chapitre 3). Curieusement, en utilisant l’ARNi comme outil d’étude du rôle de PARP-1 dans la mort cellulaire, nous avons observé que l’ARNi stable (shRNA) de nombreux gènes, incluant PARP-1, échoue lors de l’apoptose, en raison de l’inactivation catalytique par clivage par une caspase de l’endoribonucléase Dicer-1, indispensable pour la régulation de l’ARNi et des miARN (chapitre 4). Cependant, nous avons découvert que l’ARNi transitoire persiste plusieurs jours même après induction de l’apoptose, soulignant des différences entre les ARNi stable et transitoire dans la dynamique de "knockdown" génétique et dans la dépendance de la fonction de Dicer-1 (chapitre 5). En résumé, mon travail a permis la découverte des avantages et des limites de l’ARNi durant l’apoptose et le rôle de PARP-1 dans la mort cellulaire induite par les UVB.
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Miszura, Alexandre Arantes. "Efeito do crescimento compensatório sobre a puberdade de novilhas Nelore." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-18042017-142425/.

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O crescimento compensatório pode ser uma ferramenta interessante em sistemas de criação de bovinos de corte, uma vez que os animais que passam por crescimento compensatório são mais eficientes, diminuindo o custo com alimentação. É bem aceito que a nutrição é capaz de influenciar a idade à puberdade de novilhas, no entanto, pouco se sabe sobre o efeito do crescimento compensatório na puberdade de novilhas Nelore. O objetivo deste trabalho foi avaliar o efeito de ritmos de crescimento e crescimento compensatório sobre a idade e peso à puberdade de novilhas Nelore. Para isso, foram utilizadas 120 novilhas da raça Nelore, desmamadas com oito meses de idade e filhas de 6 touros que foram alocadas em quatro tratamentos de acordo com o peso inicial de 180 ± 8,6 kg. O período experimental foi dos 8 aos 18 meses de idade. Tratamentos: 1) GMD elevado (CMS d libitum), cerca de 1kg/dia, durante todo o período experimental (ALTO). 2) GMD médio (0,6kg/dia) durante o período experimental (MÉDIO). 3) Restrição alimentar por 4 meses (0,2kg/dia), seguido de CMS ad libitum com crescimento compensatório (RESTRITO). 4) CMS ad libitum (GMD elevado) por dois meses, alternando com restrição alimentar (0,2kg/dia), durante um período total de 10 meses (ALTERNADO). A restrição alimentar foi realizada através da restrição quantitativa do CMS, e o crescimento compensatório e o GMD alto foram obtidos através do CMS ad libitum. As novilhas passaram por exame ginecológico semanalmente e a manifestação da puberdade foi acompanhada por meio de US (presença de CL) e colheita de sangue (determinação de P4). Também foi determinada a concentração de IGF-1 (8, 10, 12, 14, 16 e 18 meses de idade e no momento da puberdade) e leptina (8, 11 e 18 meses de idade e no momento da puberdade). Ao final do experimento, as novilhas que não entraram em puberdade foram submetidas a um protocolo de indução de puberdade com P4. O delineamento utilizado foi em blocos casualizados incompletos (touro), sendo as variáveis contínuas analisadas pelo procedimento MIXED e as variáveis binomiais avaliadas pelos procedimentos GLIMMIX ou LIFETEST quando avaliadas as curvas de sobrevivência, todos procedimentos procedimento do SAS 9,3. Não houve diferença na porcentagem de novilhas púberes aos 18 meses de idade entre os tratamentos. O peso a puberdade e a idade a puberdade também não diferiram entre os tratamentos. Entretanto, o GMD ao longo do experimento (P<0,01) e até a puberdade (P<0,01) foi maior nas novilhas submetidas ao tratamento ALTO diferindo dos demais. Ainda, as novilhas submetidas ao tratamento ALTO apresentaram maior CMS (P<0,01) que o RESTRITO, e a magnitude dessa diferença foi de 20%. Em relação as análises de IGF-1, houve interação entre tratamento e idade (P=0,02), no qual as novilhas submetidas ao tratamento ALTERNADO apresentaram maior concentração de IGF-1 aos 12 e aos 16 meses de idade quando comparado com os outros tratamentos. A concentração de leptina foi maior (P=0,04) nas novilhas submetidas ao tratamento ALTO quando comparado com as novilhas submetidas aos tratamentos MÉDIO. Em relação a porcentagem de novilhas que responderam a indução, não houve diferença entre os tratamentos, sendo que cerca de 80% das novilhas responderam à indução. Novilhas passando por um período de restrição, seguido por um suporte nutricional eficiente, foram capazes de alcançar a puberdade em idade e peso semelhantes daquelas que não passaram por restrição. Ainda, as novilhas submetidas à restrição alimentar apresentaram menor CMS. Assim, o crescimento compensatório foi uma estratégia nutricional eficiente em reduzir o CMS, melhorando a eficiência alimentar e não prejudicou a idade à puberdade.
The aim of this study was to evaluate the effect of growth rates and compensatory growth on the age and weight at puberty of heifers. For that, 120 Nellore heifers, weaned at eight months of age, daughters of 6 bulls, with initial body weight of 180±8.6 kg were used. The experimental design was randomized blocks (sires). The experimental period was from 8 to 18 months of age. Treatments were: 1) High ADG (ad libitum DMI) throughout the experimental period (HIGH), 2) Mid ADG (0.6kg/d) throughout the experimental period (MID), 3) Feed restriction for 4 months (0.2kg/d), followed by ad libitum DMI with compensatory growth (RESTRICT), 4) ad libitum DMI (High ADG) for 2 months, alternating with feed restriction (0.2kg/d), throughout a period of 10 months (ALTERNATE). The diet was composed of ground corn (70%), sugarcane bagasse (12%), soybean meal (16%), mineral mixture (1%) and urea (1%). Weekly gynecological examination was performed, whereas the manifestation of puberty was monitored by means of ultrasonography. Additional blood samples were collected for determination of IGF-1 and leptin. At the end of the experimental period, the heifers that did not reach puberty were submitted to a puberty induction protocol with progesterone. The continuous variables were analyzed by the MIXED procedure and the binomial variables evaluated by the procedures GLIMMIX (SAS 9.3). There was no difference in the percentage of pubertal heifers at 18 months of age, weight and age at puberty between treatments. However, the ADG throughout the experiment (P<0.01) and until puberty (P<0.01) was greater in heifers submitted to HIGH, compared to the other treatments. Moreover, heifers submitted to HIGH had greater DMI (P<0.01) than the RESTRICT, with the magnitude of this difference of 20%. The feed efficiency (P<0.01) were 0.128, 0.120, 0.146 and 0.113 for HIGH, MID, RESTRICT and ALTERNATE respectively. There was treatment x age interaction (P=0.02) for IGF-1, in which the ALTERNATE had greater concentration of IGF-1 at 12 and 16 months of age when compared to the other treatments. The leptin concentration was greater (P=0.03) in HIGH when compared to the MID. In relation to the percentage of heifers that responded to the induction, there was no difference between treatments and about 80% of the heifers responded to induction. Heifers submitted to feed restriction had a reduced DMI, hence, the compensatory growth was an efficient nutritional strategy to feed efficiency and did not differ age at puberty.
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Pottier, Aurore Hénichart Jean-Pierre. "Conception, synthèse et évaluation pharmacologique de pyrrolo[3,4-b]quinoléines condensées, ligands potentiels de l'ADN." [S.l.] : [s.n.], 2003. http://www.univ-lille1.fr/bustl-grisemine/pdf/extheses/50376-2003-83-84.pdf.

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Lyonnais, Sébastien. "VIH-1, protéine de nucléocapside, ADN, Flap central et quartets de guanine : assemblages et modelages in vitro." Paris 6, 2002. http://www.theses.fr/2002PA066234.

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Books on the topic "ADH-1"

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Singh, Gurdial. Adh Chanani Raat / (Night of the Half Moon). London: Macmillan Education UK, 1996. http://dx.doi.org/10.1007/978-1-349-15103-5.

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Greg, Anderson-Clift, ed. Add, subtract, multiply, divide: Grades K-1. Westminster, CA: Teacher Created Resources, 2008.

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Occupation and Abandonment of Middle Bronze Age Zahrat Adh-Dhra' 1, Jordan: The Behavioural Implications of Quantitative Ceramic Analyses (Bar International). Archaeopress, 2006.

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Alex Ada 1. Image Comics, 2014.

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Headquarters Department of the Army. Army (ADP 1). Lulu Press, Inc., 2019.

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Akdag, Güldogan. Adi Konulmadik 1. Kibele Yayinlari, 2009.

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Monnerie-Goarin, A. Ado - Level 1. Cle International, 1999.

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2 Mahalle 1 Ada Bozcaada - Ada Monografisi. Literatür Yayinlari, 2021.

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Bennett, Jim. ADI Part 1 Examination. Jim Bennett Training Systems, 1995.

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Bennett, Jim. ADI Part 1 Examination. 2nd ed. Jim Bennett Training Systems, 2000.

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Book chapters on the topic "ADH-1"

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Colao, Annamaria, Claudia Pivonello, and Mariarosaria Negri. "Antidiuretic Hormone (ADH)." In Encyclopedia of Pathology, 1–2. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-28845-1_5100-1.

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van Delden, Wilke, and M. Hani Soliman. "Alcohol, Adh and ageing." In Drosophila as a Model Organism for Ageing Studies, 230–40. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2683-8_18.

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Kannan, C. R. "Syndrome of Inappropriate ADH Secretion." In Essential Endocrinology, 105–13. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4899-1692-1_11.

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Kannan, C. R. "Syndrome of Inappropriate Secretion of ADH." In The Pituitary Gland, 565–83. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1849-1_21.

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Reuss, Luis, and Calvin U. Cotton. "Water Transport across ADH-Sensitive Epithelia." In Contemporary Nephrology, 1–33. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0829-4_1.

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Singh, Gurdial. "Night of the Half Moon /ADH Chanani Raat." In Adh Chanani Raat / (Night of the Half Moon), 1–159. London: Macmillan Education UK, 1996. http://dx.doi.org/10.1007/978-1-349-15103-5_1.

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Beenackers, Maura, and Fiona Kat. "1 Kenmerken van ADHD." In Een patiënt met ADHD, 10–22. Houten: Bohn Stafleu van Loghum, 2011. http://dx.doi.org/10.1007/978-90-313-8255-2_1.

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Jeon, Jinsung, Jing Liu, Jayoung Kim, Jaehoon Lee, Noseong Park, Jamie Jooyeon Lee, Ozlem Uzuner, and Sushil Jajodia. "Scalable Graph Synthesis with Adj and 1 — Adj." In Proceedings of the 2021 SIAM International Conference on Data Mining (SDM), 307–15. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2021. http://dx.doi.org/10.1137/1.9781611976700.35.

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Vink, Sanne E. "Sessie 1: Uitleg ADHD-model en kernsymptomen van ADHD." In Cognitieve gedragstherapie bij volwassenen met AD(H)D, 1–13. Houten: Bohn Stafleu van Loghum, 2021. http://dx.doi.org/10.1007/978-90-368-2481-1_1.

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Sullivan, David T., Peter W. Atkinson, Cynthia A. Bayer, and Marilyn A. Menotti-Raymond. "The Evolution of Adh Expression in the Repleta Group of Drosophila." In Ecological and Evolutionary Genetics of Drosophila, 407–18. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-8768-8_26.

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Conference papers on the topic "ADH-1"

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Buchanan, M. R., E. Bastida, J. Aznar-Salatti, and P. de Groot. "IS THE ENDOTHELIAL EXTRACELLULAR MATRIX THROMBOGENIC OR THROMBORESISTANT? EFFECT OF PREPARATION AND 13-HODE LEVELS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643562.

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It is generally thought that the extracellular matrix (ECM) is thrombogenic.However,one of us (MRB) has reported that the ECM is thromboresistant,and postulated that this was due to the release of endothelial cell (EC) 13-hydroxyoctadecadienoic acid (13-HODE) into the ECM. To test this possibility, we measured platelet adhesion (PLT ADH) onto cultured ECs and their ECMs exposed by 3 methods. We also extracted the ECMs for HPLC analysis of 13-HODE.PLT ADH was expressed as i)adhesion of 3H-adenine labelled platelets/mm2 of ECs or ECMs under static conditions, and ii) % surface^ area coverage measured morphometrically following 5"perfusion with citrated whole blood at 1300 sec-1 in the flat chamber.ECMs were prepared by removing the EC monolayers by freeze thawing , cellulose acetate stripping or NH4OH treatment. PLT ADH to ECs under static and flow conditions were 4700±240/mm2 and 0.1%, respectively, and were associated with 12,6± 1 pg of 13-HODE/mm2 of EC surface (M+SEM). Removal of the ECs by freeze thawing or stripping, resulted in a 18% and 25% increase in PLT ADH to the ECM,under static and flow conditions respectively, and a 80% decrease in ECM associated 13-HODE level. Removal of the EC by NH4OH resulted in a 380% and 770% increase in PLT ADH to the ECM in static and flow conditions. 13-HODE was undetectable.These data support the hypothesis that 13-HODE released from ECs influences the ECM thrombogenecity, and indicate that the residual amounts of components present in the ECMs following EC removal is influenced by the method of ECM preparation.
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Lazko, Alexey, Larisa Udochkina, and Nina Losovskaya. "Histochemical changes of the lung tissue in experimental chronic alcoholic intoxication." In Innovations in Medical Science and Education. Dela Press Publishing House, 2022. http://dx.doi.org/10.56199/dpcsms.nrjc3772.

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Among organ systems in the human body affected by alcohol abuse, the lungs are particularly vulnerable to infections and injury. Chronic alcoholism causesalterations in host defence of the upper and lower airways, disruption of alveolar epithelial barrier integrity, alcohol-induced ciliary lesions and alveolar macrophages dysfunction. Currently with a spread of SARS-COV 2 infections which instantly destroys the lung tissue, the alcohol-induced lung damage issues acquire vital importance, as they might further increase severity of lesions of lung tissue in the infected alcohol abusers.Recent investigations suggest that the effect of the chronic excessive alcohol consumption and SARS-COV 2 infection on the lungs might have similar and thus synergizing mechanisms. Therefore the mechanism of the lung tissue lesions in chronic alcohol intoxication need to be scrutinized, including the time-line of their development, to be able to develop more effective preventive measures. The objective of the study is to assess histochemical changes in the lung tissue of laboratory animals with chronic alcohol intoxication of different duration. Total of 48 outbred male white mice weighing 18-22 g were enrolled in the study. The experimental animals were exposed to alcohol for 1, 2 and 3 months by the semi-voluntary intake, using 20% alcohol as the only source of fluid, while control animals were getting drinking water. At the end of experiment the lung tissue of the mice was processed histologically and histochemically for alcoholic dehydrogenase (ADH), glucose-6-phasphate-dehydrogenae (G6PDH), alkaline (ALP) and acidic (AP) phosphatases, nonspecific esterase (NE) and succinate dehydrogenase (SDH). Image analysis of the histological slides was performed using Image Pro Plus software. Statistical differences were assessed using paired t-test. Chronic alcohol consumption causes metabolic lesions in the alveolar epithelium and endothelium of alveolar capillaries revealed by an increase in the activity of ADH, G6PD and NE paralleled with a decrease in the total SDH activity of the respiratory portion of the lungs in a time-related pattern. High activity of alkaline phosphatase was noted in endothelial cells of lung capillaries. Thus, under conditions of chronic intoxication, ethanol disturbs cell metabolism, as evidenced by the changes of the enzymatic activity in the lung tissue which leads to inhibition of oxygen-dependent metabolic processes and activation of reserve mechanisms for compensating of energy deficits.
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Danesh, Mohammadhadi, and Arindam Sanyal. "Fully Digital 1-1 MASH VCO-Based ADC Architecture." In 2019 IEEE 62nd International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2019. http://dx.doi.org/10.1109/mwscas.2019.8884925.

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Vasishta, Sudhanva, K. R. Raghunandan, and Ananth Dodabalapur. "A Sawtooth Relaxation ICO based 1-1 MASH ADC." In 2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2020. http://dx.doi.org/10.1109/mwscas48704.2020.9184696.

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Agarwal, Kailash C. "NEW INSIGHTS INTO THE ANTIPLATELET ACTIVITY OF FORSKOLIN: ROLE OF PLASMA ADENOSINE AND SPECIES DIFFERENCES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643584.

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Forskolin stimulates adenylate cyclase by interacting with the catalytic subunit and inhibits platelet aggregation. This inhibition is greatly potentiated by adenosine (Ado) which stimulates adenylate cyclase through membrane-bound Ado receptors. Forskolin is 2-4 fold more potent as an inhibitor of collagen-induced rat platelet aggregation as compared to human platelets (IC50 values, in rat PRP, 0.5-0.8 μM; in human PRP, 1.5-2 μM). However, if the blood is pretreated with adenosine deaminase (ADA), an enzyme that degrades Ado to inosine, the inhibitory action of forskolin is greatly reduced producing similar effects both in human and rat PRPs (IC50, 2-3 μM) and whole blood (IC50, 4.6 μM). Both 5’-methylthioadenosine (MTA, 50-100 μM), an antagonist of Ado receptors, and 2’,5’-dideoxyadenosine (DDA, 100 μM), an inhibitor of adenylate cyclase, reverse the inhibition of platelet aggregation in rat PRP, whereas, no reversal is seen in human PRP. When Ado in the rat plasma is degraded by ADA pretreatment, DDA or MTA shows no reversal as seen in human PRP. The inhibitory action of forskolin (1-2 μM), which is only weakly inhibitory alone (<20%) in human whole blood, can be greatly potentiated (100% inhibition) by the inhibitors of nucleoside transport, dipyridamole (10 μM) or dilazep (2 μM). Only slight potentiation is seen in rat whole blood suggesting that rat plasma Ado levels are not affected significantly perhaps due to weakly active erythrocytic nucleoside transport system. Sato and Ui (In: Physiology and Pharmacology of Adenosine, Daly et al, Eds. Raven Press, 1983, 1-11), have shown that rat plasma contains much higher Ado levels (7.55 ± 0.51 pM) than human plasma (0.29 ± 0.08 μM). These studies demonstrate that plasma adenosine plays an important role in the forskolin antiplatelet activity which can be greatly potentiated in human whole blood by the clinically used drugs, dipyridamole and dilazep. (Supported by US PHS Grant CA 07340).
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Koneti Rao, A., and Maria A. Kowalska. "ADP-INDUCED CYTOPLASMIC CALCIUM MOBILIZATION AND SHAPE CHANGE IN PLATELETS ARE MEDIATED BY DIFFERENT BINDING SITES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644466.

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Platelet stimulation with ADP results in a number of responses including increase in cytoplasmic ionized calcium concentration [Ca2+]i, shape change, aggregation, secretion, and inhibition of cAMP accumulation caused by PGI2.5'-Fluorosulphonylbenzoyladenosine (FSBA), which covalently labels ADP binding site on platelets, blocks platelet shape change but not inhibition of cyclic AMP levels by ADP, while p-chloromercuribenzenesulfonate (pCMBS), a non-penetrating thiol reagent, blocks ADP-induced inhibition of adenylate cyclase but not shape change. We examined the effect of FSBA and pCMBS on ADP-induced increase in [Ca2+]i to determine whether it is linked to the binding site mediating shape change or that for inhibition of adenylate cyclase. In platelets loaded with Ca2+ indicators, quin 2 or fura 2, and in presence of adenosine deaminase (AD), FSBA (50-200 μM) induced a dose-dependent, rapid rise in [Ca2+]i. from basal levels of 70-90 nM to peak levels of 300-500 nM in the presence of 1 mM external Ca2+ providing direct evidence that FSBA is a platelet agonist. The [Ca2+ ]i. returned to near basal levels over 30 min. The effect of FSBA on [Ca2+]i. was inhibited by ZK 36,374 (40 nM), a stable PGI2 analog. AdP concentrations eliciting similar responses were about 10-fold less than those for FSBA. Platelet incubation with FSBA (50-100 μM) in the presence of AD for 30 min (to ensure optimal covalent labelling of the ADP binding sites) abolished shape change but jjid not inhibit ADP (5, 25 μM)-induced increase in [Ca2+]i. or block the inhibitory effect of ADP on cAMP accumulation in1platelets exposed to ZK 36,374 (50 nM) in.presence of theophylline (7 mM). Incubation with pCMBS (5-100 pM, 2 min) abolished the effect of ADP on [Ca2+]. and on the inhibition of cAMP levels; shape change was not 1 inhabited even at 1 mM. pCMBS (0.5-1 mM) inhibited the rise in [Ca2+ ]. by FSBA alone. These observations suggest that ADP-induced Ca mobilization is mediated by platelet binding sites which are distinct from those mediating shape change but probably the same as those modulating adenylate cyclase.
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Chandrasekaran, Sanjeev Tannirkulam, Sumukh P. Bhanushali, Stefano Pietri, and Arindam Sanyal. "OTA-free 1-1 MASH ADC using Fully Passive Noise Shaping SAR & VCO ADC." In 2021 Symposium on VLSI Circuits. IEEE, 2021. http://dx.doi.org/10.23919/vlsicircuits52068.2021.9492344.

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Tsoumanis, Kostas, Kiamal Pekmestzi, and Constantinos Efstathiou. "Fused modulo 2n + 1 Add-Multiply unit for diminished-1 operands." In 2016 5th International Conference on Modern Circuits and Systems Technologies (MOCAST). IEEE, 2016. http://dx.doi.org/10.1109/mocast.2016.7495110.

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Maghami, Hamidreza, Pedram Payandehnia, Hossein Mirzaie, Kartikeya Mayaram, Ramin Zanbaghi, and Terri Fiez. "A highly linear OTA-free VCO-based 1-1 MASH ΔΣ ADC." In 2017 IEEE International Symposium on Circuits and Systems (ISCAS). IEEE, 2017. http://dx.doi.org/10.1109/iscas.2017.8050625.

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Shen, Gangxiang. "Service Provisioning and Performance in 1+1/1:1 Survivable Optical Networks with Limited Add/Drop Ports and Transmitter Tunability." In 2007 the Joint International Conference on Optical Internet (COIN) and Australian Conference on Optical Fibre Technology (ACOFT). IEEE, 2007. http://dx.doi.org/10.1109/coinacoft.2007.4519115.

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Reports on the topic "ADH-1"

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Bell, Gary, David Abraham, Nathan Clifton, and Lamkin Kenneth. Wabash and Ohio River confluence hydraulic and sediment transport model investigation : a report for US Army Corps of Engineers, Louisville District. Engineer Research and Development Center (U.S.), March 2022. http://dx.doi.org/10.21079/11681/43441.

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Avulsions of the Wabash River in 2008 through 2011 at its confluence with the Ohio River resulted in significant shoaling in the Ohio River. This caused a re-alignment of the navigation channel and the need for frequent dredging. A two-dimensional numerical hydrodynamic model, Adaptive Hydraulics (AdH), was developed to simulate base (existing) conditions and then altered to simulate multiple alternative scenarios to address these sediment issues. The study was conducted in two phases, Phase 1 in 2013 – 2015 and Phase 2 in 2018 – 2020. Field data were collected and consisted of multi-beam bathymetric elevations, bed sediment samples, suspended sediment samples, and discharge and velocity measurements. The model hydrodynamic and sediment transport computations adequately replicated the water surface slope, flow splits, bed sediment gradations, and suspended sediment concentrations when compared with field data. Thus, it was shown to be dependable as a predictive tool. The alternative that produced the most desirable results included a combination of three level-crested emergent dikes on Wabash Island and four submerged dikes on the Illinois shore with a level crest from the bank to the tip of the dike. The selected alternative produced an improved sailing line while maintaining authorized channel depths.
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Pesis, Edna, and Mikal Saltveit. Postharvest Delay of Fruit Ripening by Metabolites of Anaerobic Respiration: Acetaldehyde and Ethanol. United States Department of Agriculture, October 1995. http://dx.doi.org/10.32747/1995.7604923.bard.

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The use of pretreatments for 24 h prior to storage, under anaerobic condtions, or in the presence of the natural metabolic products, acetaldehyde (AA) and ethanol, to delay fruit ripening, was found to be effective with several climacteric fruits, among them avocado, mango, peach and tomato. The delay in ripening of avocado, peach and tomato was accompanied by inhibition of ethylene production and of fruit softening. The maintenance of fruit firmness was associated with a decrease in the activities of cell-wall-degrading enzymes, including endoglucanases (Cx), polygalacturonases (PG) and b-galactosidases. In peaches the AA- and N2-treated fruits were firmer after 3 weeks storage and contained higher amount of insoluble pectin than untreated controls. We showed that AA vapors are able to inhibit ripening, ethylene production and ethylene induction in the presence of 1-amino-cyclopropane-1-carboxylic acid (ADD) in avocado and mango tissue. Ethylene induced by ACC is taken as an indicator of ACC oxidase activity. ACC oxidase activity in AA-treated avocado fruit was much lower than in the untreated fruit. In carnation flowers very little ethylene was produced by ethanol-treated flowers, and the normal increases in ACC content and ACC oxidase activity were also suppressed. Using kinetic studies and inhibitors of alcohol dehydrogenase (ADH), we showed that AA, not ethanol, was the active molecule in inhibiting ripening of tomato fruit. Application of anaerobiosis or anaerobic metabolites was effective in reduction of chilling injury (CI) in various plant tissues. Pretreatment with a low-O2 atmosphere reduced CI symptoms in avocado; this effect was associated with higher content of the free sylfhydryl (SH) group, and induction of the detoxification enzymes, catalase and peroxidase. Application of AA maintained firmer and brighter pulp tissue (non-oxidative), which was associated with higher free SH content, lower ethylene and ACC oxidase activities, and higher activities of catalase and peroxidase. Ethanol was found to reduce CI in other plant tissue. In roots of 24-h-old germinated cucumber seeds, exposure to 0.4-M ethanol shock for 4 h reduced chilling-induced ion leakage. In cucumber cotyledons it appears that alcohols may reduce CI by inducing stomata closure. In cotyledon discs held in N2 at 10C for 1 day, there accumulated sufficient endogenously synthesized ethanol to confer tolerance to chilling at 2.5C for 5 days.
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Ardoin, Cy, Paul Baker, Robert Dewar, Doug Dunlop, and Paul Hilfinger. Ada 9X Project Report: Ada 9X Revision Issues. Release 1. Fort Belvoir, VA: Defense Technical Information Center, April 1990. http://dx.doi.org/10.21236/ada222331.

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Hobbs, Reginald L., Joseph J. Nealon, and Richard Wassmuth. Ada Transition Research Project (Phase 1). Fort Belvoir, VA: Defense Technical Information Center, December 1990. http://dx.doi.org/10.21236/ada268439.

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Ramsey, Norman. Penelope: An Ada Verification Environment, Developing Formally Verified Ada Programs. Volume 1. Fort Belvoir, VA: Defense Technical Information Center, November 1991. http://dx.doi.org/10.21236/ada249417.

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Ausnit, C. N., E. R. Ansarov, and N. H. Cohen. Program Office Guide to Ada. Edition 1. Fort Belvoir, VA: Defense Technical Information Center, September 1986. http://dx.doi.org/10.21236/ada183226.

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Johnston, B. L. Addendum, automatic data processing (ADP) security plan, Revision 1. ADP facility number: PNL-63. Office of Scientific and Technical Information (OSTI), June 1989. http://dx.doi.org/10.2172/10118490.

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8

Dodds, Philip, and Scott Lewis. The ADL Registry and CORDRA. Volume 1: General Overview. Fort Belvoir, VA: Defense Technical Information Center, August 2008. http://dx.doi.org/10.21236/ada488058.

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9

Shiltsev, V. The first colliders: AdA, VEP-1 and Princeton-Stanford. Office of Scientific and Technical Information (OSTI), July 2013. http://dx.doi.org/10.2172/1128065.

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Marceau, Carla. Penelope Reference Manual, Version 3-3 (COO 1), includes Larch/Ada Specification Manual for Sequential Ada (C002). Fort Belvoir, VA: Defense Technical Information Center, September 1994. http://dx.doi.org/10.21236/ada289828.

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