Relevant bibliographies by topics / Adenoviruses

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Adenoviruses'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "Adenoviruses"

1

Niczyporuk, Jowita Samanta, Elżbieta Samorek-Salamonowicz, and Hanna Czekaj. "Occurrence of Adenovirus Field Strains in Birds Infected with Marek’S Disease Virus." Bulletin of the Veterinary Institute in Pulawy 56, no. 4 (December 1, 2012): 435–40. http://dx.doi.org/10.2478/v10213-012-0077-2.

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Abstract The strains of adenoviruses were isolated from 356 birds with clinical form of Marek’s disease and coinfection with adenoviruses. A hexon gene fragment coding loop L1 of adenovirus strains was sequenced and obtained data were analysed with BLAST, Geneious 5.3, and MEGA5 software by comparison with nucleotide sequences of reference strains of fowl adenoviruses (FAdV-1 - FadV-12), two turkey adenoviruses, and two goose adenovirus strains. On this basis, serotypes of adenovirus strains were determined. Sequences of all adenovirus strains isolated from birds infected with Marek’s disease virus were classified into six serotypes representing four species. Mostly FAdV-7, FAdV2/11, and FAdV-8a serotypes were found.
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Abbink, Peter, Lori F. Maxfield, David Ng'ang'a, Erica N. Borducchi, M. Justin Iampietro, Christine A. Bricault, Jeffrey E. Teigler, et al. "Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors." Journal of Virology 89, no. 3 (November 19, 2014): 1512–22. http://dx.doi.org/10.1128/jvi.02950-14.

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ABSTRACTAdenovirus vectors are widely used as vaccine candidates for a variety of pathogens, including HIV-1. To date, human and chimpanzee adenoviruses have been explored in detail as vaccine vectors. The phylogeny of human and chimpanzee adenoviruses is overlapping, and preexisting humoral and cellular immunity to both are exhibited in human populations worldwide. More distantly related adenoviruses may therefore offer advantages as vaccine vectors. Here we describe the primary isolation and vectorization of three novel adenoviruses from rhesus monkeys. The seroprevalence of these novel rhesus monkey adenovirus vectors was extremely low in sub-Saharan Africa human populations, and these vectors proved to have immunogenicity comparable to that of human and chimpanzee adenovirus vaccine vectors in mice. These rhesus monkey adenoviruses phylogenetically clustered with the poorly described adenovirus species G and robustly stimulated innate immune responses. These novel adenoviruses represent a new class of candidate vaccine vectors.IMPORTANCEAlthough there have been substantial efforts in the development of vaccine vectors from human and chimpanzee adenoviruses, far less is known about rhesus monkey adenoviruses. In this report, we describe the isolation and vectorization of three novel rhesus monkey adenoviruses. These vectors exhibit virologic and immunologic characteristics that make them attractive as potential candidate vaccine vectors for both HIV-1 and other pathogens.
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Moore, P. L., A. D. Steele, and J. J. Alexander. "Relevance of Commercial Diagnostic Tests to Detection of Enteric Adenovirus Infections in South Africa." Journal of Clinical Microbiology 38, no. 4 (2000): 1661–63. http://dx.doi.org/10.1128/jcm.38.4.1661-1663.2000.

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The prevalence of enteric adenoviruses detected by an in-house enzyme-linked immunosorbent assay (the RIVM-ELISA) ranged from 13 to 38%, and subgroup F adenoviruses comprised 86%. All subgroup F adenoviruses reacted with both RIVM anti-adenovirus type 40 (Ad40) and anti-adenovirus type 41 (Ad41) monoclonal antibodies but were not detected by Adenoclone Type 40/41 enzyme immunoassay (EIA). The correlation between the Biotrin EIA and RIVM-ELISA results was low (26%). Immunospecific tests suggest that a significant proportion of enteric adenoviruses, possibly comprising previously unidentified or emerging types, are not detected by commercial diagnostic tests in South Africa.
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Zhang, Wenli, Kemal Mese, Sebastian Schellhorn, Nora Bahlmann, Nicolas Mach, Oskar Bunz, Akshay Dhingra, et al. "High-Throughput Cloning and Characterization of Emerging Adenovirus Types 70, 73, 74, and 75." International Journal of Molecular Sciences 21, no. 17 (September 2, 2020): 6370. http://dx.doi.org/10.3390/ijms21176370.

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Recently an increasing number of new adenovirus types associated with type-dependent pathogenicity have been identified. However, identification of these clinical isolates represents the very first step to characterize novel pathogens. For deeper analyses, these adenoviruses need to be further characterized in basic virology experiments or they could be applied in translational research. To achieve this goal, it is essential to get genetic access and to enable genetic modification of these novel adenovirus genomes (deletion, insertion, and mutation). Here we demonstrate a high-throughput approach to get genetic access to new adenoviruses via homologous recombination. We first defined the cloning conditions regarding homology arm-length and input adenoviral genome amounts. Then we cloned four naturally occurring adenoviruses (Ad70, Ad73, Ad74, and Ad75) into easy-to-manipulate plasmids and genetically modified them by reporter gene insertion. Three recombinant adenoviruses (Ad70, Ad73, and Ad74) containing a reporter cassette were successfully reconstituted. These novel reporter-labeled adenoviruses were further characterized using the inserted luciferase reporter with respect to receptor usage, presence of anti-adenovirus antibodies, and tropism in vitro. The identified receptor usage, the relatively low prevalence of anti-adenovirus antibodies, and the various cancer cell line transduction pattern are important features of these new pathogens providing essential information for their therapeutic application.
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Maluquer de Motes, Carlos, Pilar Clemente-Casares, Ayalkibet Hundesa, Margarita Mart�n, and Rosina Girones. "Detection of Bovine and Porcine Adenoviruses for Tracing the Source of Fecal Contamination." Applied and Environmental Microbiology 70, no. 3 (March 2004): 1448–54. http://dx.doi.org/10.1128/aem.70.3.1448-1454.2004.

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ABSTRACT In this study, a molecular procedure for the detection of adenoviruses of animal origin was developed to evaluate the level of excretion of these viruses by swine and cattle and to design a test to facilitate the tracing of specific sources of environmental viral contamination. Two sets of oligonucleotides were designed, one to detect porcine adenoviruses and the other to detect bovine and ovine adenoviruses. The specificity of the assays was assessed in 31 fecal samples and 12 sewage samples that were collected monthly during a 1-year period. The data also provided information on the environmental prevalence of animal adenoviruses. Porcine adenoviruses were detected in 17 of 24 (70%) pools of swine samples studied, with most isolates being closely related to serotype 3. Bovine adenoviruses were present in 6 of 8 (75%) pools studied, with strains belonging to the genera Mastadenovirus and Atadenovirus and being similar to bovine adenoviruses of types 2, 4, and 7. These sets of primers produced negative results in nested PCR assays when human adenovirus controls and urban-sewage samples were tested. Likewise, the sets of primers previously designed for detection of human adenovirus also produced negative results with animal adenoviruses. These results indicate the importance of further studies to evaluate the usefulness of these tests to trace the source of fecal contamination in water and food and for environmental studies.
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Liu, Minli, Lefang Jiang, Weihua Cao, Jianguo Wu, and Xulin Chen. "Identification of Inhibitors and Drug Targets for Human Adenovirus Infections." Viruses 14, no. 5 (May 4, 2022): 959. http://dx.doi.org/10.3390/v14050959.

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Adenoviruses can cause infections in people of all ages at all seasons of the year. Adenovirus infections cause mild to severe illnesses. Children, immunocompromised patients, or those with existing respiratory or cardiac disease are at higher risk. Unfortunately, there are no commercial drugs or vaccines available on the market for adenovirus infections. Therefore, there is an urgent need to discover new antiviral drugs or drug targets for adenovirus infections. To identify potential antiviral agents for adenovirus infections, we screened a drug library containing 2138 compounds, most of which are drugs with known targets and past phase I clinical trials. On a cell-based assay, we identified 131 hits that inhibit adenoviruses type 3 and 5. A secondary screen confirmed the antiviral effects of 59 inhibitors that inhibit the replication of adenoviruses type 3 or 5. Most of the inhibitors target heat shock protein, protein tyrosine kinase, the mTOR signaling pathway, and other host factors, suggesting that these host factors may be essential for replicating adenoviruses. Through this study, the newly identified adenovirus inhibitors may provide a start point for developing new antiviral drugs to treat adenovirus infections. Further validation of the identified drug targets can help the development of new therapeutics against adenovirus infections.
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Dirven, Clemens M. F., Jacques Grill, Martine L. M. Lamfers, Paul van der Valk, Angelique M. Leonhart, Victor W. van Beusechem, Hidde J. Haisma, et al. "Gene therapy for meningioma: improved gene delivery with targeted adenoviruses." Journal of Neurosurgery 97, no. 2 (August 2002): 441–49. http://dx.doi.org/10.3171/jns.2002.97.2.0441.

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Object. Due to their surgical inaccessibility or aggressive behavior, some meningiomas cannot be cured with current treatment strategies. Gene therapy is an emerging strategy for the treatment of brain tumors, which the authors investigated to determine whether adenoviruses could be used for gene transfer in meningioma cells. Methods. The presence of the high-affinity Coxsackievirus and adenovirus receptor (CAR) for adenovirus type 5, as well as endothelial growth factor receptor (EGFR) and alphav integrins (ITGAVs), were analyzed in primary tumors by using immunohistochemical studies and in primary meningioma cell cultures by using fluorescence-activated cell sorting. Targeting of adenoviruses to EGFR was achieved using bispecific antibodies, whereas targeting of adenoviruses to the ITGAVs was accomplished by insertion of an RGD (arginine-glycine-aspartic acid) motif in the adenovirus fiber HI loop. Gene transfer efficiency of untargeted and targeted vectors was compared in primary cell cultures and in spheroids derived from patients' resected tumor material. The presence of CARs was observed in all tumors and in all but one of the derived primary meningioma cells. The higher expression of EGFRs and ITGAVs indicated that these receptors could be used as alternative targets to redirect the adenoviruses. Redirection of adenoviruses to the EGFRs or integrins enhanced gene transfer threefold (range two—sevenfold) for EGFRs in primary meningioma cells and ninefold (range three—23-fold) for integrins (p = 0.002, analysis of variance). The effect of adenovirus targeting was confirmed in spheroids composed of primary meningioma cells. Conclusions. Gene transfer with adenoviruses targeted to tumor-specific receptors is very effective in primary meningioma cells and spheroids. These vectors are promising agents for gene therapy of meningiomas.
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Segerman, Anna, John P. Atkinson, Marko Marttila, Veronica Dennerquist, Göran Wadell, and Niklas Arnberg. "Adenovirus Type 11 Uses CD46 as a Cellular Receptor." Journal of Virology 77, no. 17 (September 1, 2003): 9183–91. http://dx.doi.org/10.1128/jvi.77.17.9183-9191.2003.

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ABSTRACT The 51 human adenovirus serotypes are divided into six species (A to F). Many adenoviruses use the coxsackie-adenovirus receptor (CAR) for attachment to host cells in vitro. Species B adenoviruses do not compete with CAR-binding serotypes for binding to host cells, and it has been suggested that species B adenoviruses use a receptor other than CAR. Species B adenoviruses mainly cause disease in the respiratory tract, the eyes, and in the urinary tract. Here we demonstrate that adenovirus type 11 (Ad11; of species B) binds to Chinese hamster ovary (CHO) cells transfected with CD46 (membrane cofactor protein)-cDNA at least 10 times more strongly than to CHO cells transfected with cDNAs encoding CAR or CD55 (decay accelerating factor). Nonpermissive CHO cells were rendered permissive to Ad11 infection upon transfection with CD46-cDNA. Soluble Ad11 fiber knob but not Ad7 or Ad5 knob inhibited binding of Ad11 virions to CD46-transfected cells, and anti-CD46 antibodies inhibited both binding of and infection by Ad11. From these results we conclude that CD46 is a cellular receptor for Ad11.
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Hesse, Andrea, Daniela Kosmides, Roland E. Kontermann, and Dirk M. Nettelbeck. "Tropism Modification of Adenovirus Vectors by Peptide Ligand Insertion into Various Positions of the Adenovirus Serotype 41 Short-Fiber Knob Domain." Journal of Virology 81, no. 6 (December 27, 2006): 2688–99. http://dx.doi.org/10.1128/jvi.02722-06.

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ABSTRACT Recombinant adenoviruses have emerged as promising agents in therapeutic gene transfer, genetic vaccination, and viral oncolysis. Therapeutic applications of adenoviruses, however, would benefit substantially from targeted virus cell entry, for example, into cancer or immune cells, as opposed to the broad tropism that adenoviruses naturally possess. Such tropism modification of adenoviruses requires the deletion of their natural cell binding properties and the incorporation of cell binding ligands. The short fibers of subgroup F adenoviruses have recently been suggested as a tool for genetic adenovirus detargeting based on the reduced infectivity of corresponding adenovectors with chimeric fibers in vitro and in vivo. The goal of our study was to determine functional insertion sites for peptide ligands in the adenovirus serotype 41 (Ad41) short fiber knob. With a model peptide, CDCRGDCFC, we could demonstrate that ligand incorporation into three of five analyzed loops of the knob, namely, EG, HI, and IJ, is feasible without a loss of fiber trimerization. The resulting adenovectors showed enhanced infectivity for various cell types, which was superior to that of viruses with the same peptide fused to the fiber C terminus. Strategies to further augment gene transfer efficacy by extension of the fiber shaft, insertion of tandem copies of the ligand peptide, or extension of the ligand-flanking linkers failed, indicating that precise ligand positioning is pivotal. Our study establishes that internal ligand incorporation into a short-shafted adenovirus fiber is feasible and suggests the Ad41 short fiber with ligand insertion into the top (IJ loop) or side (EG and HI loops) of the knob domain as a novel platform for genetic targeting of therapeutic adenoviruses.
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Crenshaw, Brennetta J., Leandra B. Jones, Courtnee’ R. Bell, Sanjay Kumar, and Qiana L. Matthews. "Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy." Biomedicines 7, no. 3 (August 19, 2019): 61. http://dx.doi.org/10.3390/biomedicines7030061.

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Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenoviral infections.
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Dissertations / Theses on the topic "Adenoviruses"

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Al, Qurashi Yasir Mohammed A. "Molecular typing of adenoviruses." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506268.

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Rodríguez, Eduardo. "Virion- and VAP-receptor recognition in the human adenovirus type 2 system." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945080.html.

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Mamadatokhonova, Guldasta. "Detection of adenoviruses in cattle /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/10573858.pdf.

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Marttila, Marko. "Cellular receptors for species B adenoviruses." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1351.

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Hamdan, Salehhuddin. "Studies on the use of adenoviruses and adenovirus structural proteins in gene transfer to human cells." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414283.

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Alissa, Alkhalaf Moustafa. "Molecular analysis of adenoviruses from clinical samples." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/molecular-analysis-of-adenoviruses-from-clinical-samples(4b2e8cca-da89-4c8f-a4cc-8dffc489fa49).html.

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At present, 56 types of human adenovirus (HAdVs) have been identified and found to be associated with a variety of clinical features in the respiratory tract, eye, gastrointestinal tract, and other organs. In additions, HAdVs are able to establish persistent and latent infections in humans. Most of the work which has been carried out recently is related to adenovirus vectors and little has been done in other areas such as the nature and mechanisms of adenovirus persistence and latency in human tissues. Another area needing more investigation is the stability of the adenovirus genome which is useful for the development of adenovirus vectors and vaccines and for better understanding of adenovirus evolution especially with conflicting views about this issue.Recombination between two types of adenovirus can happen when the hexon epitope from one type and the fibre epitope from another type are found (intermediate strains). These recombinants can be detected by the conflicting results for serum neutralization (SN) and haemagglutination inhibition (HI) tests or by sequencing and phylogenetic analysis of the hexon and fibre regions of the adenovirus genome. The first part of this study is related to the stability and evolution of different adenovirus species. A total of 31 clinical isolates from AIDS patients previously typed in the hexon L2 region and the fibre knob region were analysed. These isolates were found to be from species D adenovirus (HAdV-D) and 28 of them had contradictory typing results in these two regions so they are clearly intermediate strains. Two isolates appear to be completely new and one isolate (Aids32) was typed as HAdV-D23 variant in both hexon L2 and fibre knob regions. Sequencing and phylogenetic analysis of the hexon L1, fibre shaft and penton regions of these adenoviruses revealed that no intragene recombination events occurred between the hexon L1 and L2 regions or between the fibre knob and fibre shaft regions. Sequencing and phylogenetic analysis of the penton showed that some of the intermediate strains had sequences from a third type of adenovirus in these regions. The penton analysis showed also that intragene recombination between penton HVR and RGD loop regions was common. New types of adenovirus were detected and sequential infection with different adenovirus variants was observed in some patients which indicates that the genome of HAdV-D from AIDS patients are not stable. Full genome sequencing and analysis was carried out for three isolates, two of them appeared to be new types of HAdV-D and the result of multi-recombination events and the third isolate appeared to be a variant of HAdV-D23.The stability of species B adenovirus (HAdV-B) was also analysed. A total of 96 isolates collected from the Manchester area typed previously by serum neutralization (SN) were analysed in five genome regions. Most of these isolates were HAdV-B3 and HAdV-B7 collected during a 15 months outbreak. The rest of the isolates were HAdV-B types 3 and 7 collected in different years following the outbreak in addition to other adenovirus types isolated from different years. The phylogenetic analysis results of all the isolates in the structural regions: hexon L2, penton and fibre knob were found to be consistent and no mismatches (hexon from one type and fiber from another type) were observed. Most of the isolates in the DNA polymerase and E1A regions had the same clustering patterns as the structural regions. However, one HAdV-B7 and one HAdV-B11 isolate changed their clustering patterns in the DNA polymerase region. In addition, HAdV-B16 isolates changed their clustering patterns in both DNA polymerase and E1A regions. The changes of the clustering patterns of some isolates is more likely related to natural variations rather than recombination which indicate that species B adenovirus genome is stable in general. The last part of this study is investigating adenovirus persistence and latency in human tissues. Tonsils and adenoids (106 right and left tonsils and 10 adenoids) were obtained from 57 patients who underwent routine tonsillectomies and/or adenoidectomies. Eighty four (72.41%) tonsils and adenoids samples were positive for HAdV by real-time PCR. The viral load was not the same in the right and left tonsils in most of the cases and ranged from 280 to more than 2.6 x 106 copies/107 cells. Seventy eight of 84 positive samples could be typed by sequencing of the hexon L1 region. Species C types were detected in 82% of the samples followed by species B (7.7%), HAdV-E4 (7.7%) and HAdV-F41 (2.56%). No DNA methylation was detected in the major late promoter (MLP) and E1A promoter regions of six tonsils and adenoids samples and two clinical isolates.
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Farrera, Sal Martí. "Enhanced hyaluronidase and tumor neoepitope expression by oncolytic adenoviruses." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671748.

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The oncolytic viruses (OVs) preferentially infect tumor and selectively replicate in cancer cells without harming normal tissues. OVs have been tested in clinical trials as monotherapy or combined with chemotherapy, radiotherapy, and immunotherapy. Nonetheless, the intratumoral spreading and the immune response hamper the treatment efficacy. In this thesis, these two challenges have been addressed in three separate chapters. First, VCN-01, a hyaluronidase-expressing oncolytic adenovirus, was tested in a clinical trial in pancreatic cancer patients. We assessed the immune response triggered by VCN-01 as monotherapy or in combination with chemotherapy. We reported an early anti-viral immune response induction of IL-6, IL-10, IFNγ, IDO1, IP-10, and sLAG-3 in serum, independently of chemotherapy. We found a correlation between treatment toxicity and the IL-6 and IL-10. Furthermore, the triggered anti-viral immune response such as IFNγ, sLAG-3, and neutralizing antibodies anti-Ad5 was associated with better antitumor activity in patients. The neoepitope vaccines have been tested in patients with limited clinical responses. We hypothesized that an oncolytic adenovirus (OAd) encoding for stroma.
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Kallioinen, Susanna. "Modification of the E1-pIX region of the adenovirus 5 genome for use in cancer gene therapy /." St Andrews, 2008. http://hdl.handle.net/10023/442.

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Ganly, Ian. "E1B attenuated adenoviruses in genetic therapy for cancer." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266588.

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Fajardo, Calderón Carlos Alberto. "Arming oncolytic adenoviruses with bi-specific T-cell engagers to improve antitumor efficacy." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/403492.

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Oncolytic adenoviruses that selectively replicate in cancer cells while sparing normal tissue have gained considerable attention as novel anticancer drugs. However, clinical trials with these viruses have identified the immune system as a major hurdle for their success in cancer patients. Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently cleared by virus-specific infiltrating cytotoxic T lymphocytes without compromising tumor burden. We hypothesize that arming oncolytic adenoviruses with bi-specific T-cell engagers (BiTEs), a new class of antibodies that re-direct T-cells to cancer cells, might favor antitumor rather than anti-viral immune responses. We have engineered the oncolytic adenovirus ICOVIR-15K to express EGFR-targeting BiTEs under the control of the major late promoter. ICOVIR-15K armed with a BiTE targeting human CD3 and EGFR (ICOVIR-15K-cBiTE) was successfully rescued and it showed similar oncolytic properties as the parental virus. cBiTE expression and secretion was detected in supernatants from ICOVIR-15K-cBiTE-infected cells, and the secreted BiTEs bound specifically to both CD3+ and EGFR+ cells. In cell co-culture assays, ICOVIR-15K-cBiTE-mediated oncolysis resulted in robust T-cell activation, proliferation, and bystander cell-mediated cytotoxicity. Notably, intratumoral injection of this cBiTE-expressing adenovirus increased the persistence and accumulation of tumor-infiltrating T cells in vivo. Moreover, in two distinct tumor xenograft models, combined delivery of ICOVIR-15K-cBiTE with peripheral blood mononuclear cells or T cells enhanced the antitumor efficacy achieved by the parental counterpart. We also demonstrate that another oncolytic adenovirus expressing a chimeric BiTE targeting human EGFR and mouse CD3 (ICOVIR-15K-mcBiTE) induce robust mouse T-cell activation, proliferation, and cell-mediated cytotoxicity of cancer cells in vitro. Thus, ICOVIR-15K-mcBiTE is a promising surrogate of ICOVIR-15K-cBiTE that will aid in future pharmacological and toxicological preclinical studies of BiTE-armed oncolytic adenoviruses. Finally, we show that the combination of ICOVIR-15K-cBiTE with chimeric antigen receptor T-cell therapy can overcome some of the limitations encountered by both agents as monotherapies. The results described in this thesis demonstrate that BiTE-armed oncolytic adenoviruses hold properties with the potential of solving key limitations in oncolytic virotherapy, and encourage their further evaluation and development.
Los virus oncolitos, capaces de infectar selectivamente células cancerosas sin afectar aquellas sanas, han despertado interés en los últimos años como nueva terapia contra el cáncer. Sin embargo, los ensayos clínicos con estos virus han demostrado que el sistema inmune supone un obstáculo para el éxito de los mismos en pacientes con cáncer. A pesar de la inmunosupresión que se observa en el ambiente tumoral, las células cancerosas infectadas por el adenovirus pueden ser eliminadas eficientemente por los linfocitos T anti-adenovirales sin comprometer la carga tumoral. La hipótesis de esta tesis es que adenovirus oncoliticos expresando bi-specific T-cell engagers (BiTEs por sus siglas en inglés) capaces de redirgirir los linfocitos T para atacar las células cancerosas, puede favorecer la respuesta inmune antitumoral sobre la antiviral. El genoma del adenovirus oncolitico ICOVIR-15K fue modificado genéticamente para expresar BiTEs contra el receptor del factor de crecimiento epidérmico (EGFR por sus siglas en inglés) bajo el control del promotor mayor tardío. El virus ICOVIR-15K expresando un BiTE que reconoce el EGFR y el CD3 humanos (ICOVIR-15K-cBiTE) fue generado y retuvo propiedades oncoliticas similares a la del virus parental in vitro. La expresión y secreción del cBiTE fue detectada en los sobrenadantes de células infectadas ICOVIR-15K-cBiTE, y sus propiedades de unión a células CD3+ o EGFR+ fueron confirmadas in vitro. En experimentos de cocultivos, la oncolisis generada por ICOVIR-15K-cBiTE indujo la activación y proliferación de los linfocitos T, y aumentó la citotoxicidad de células cancerosas. La inyección de este adenovirus aumentó la persistencia y la acumulación de linfocitos infiltrantes de tumor in vivo. Adicionalmente, experimentos en modelos murinos de cáncer basados en la administración combinada de ICOVIR-15K-cBiTE y linfocitos humanos demostraron un aumento en la eficacia antitumoral comparado con el virus parental. Por último, hemos demostrado que la combinación de ICOVIR-15K-cBiTE y linfocitos T con receptores de antígeno quiméricos (CAR por sus siglas en inglés) pueden superar muchas de las carencias que tienen ambas terapias. Los resultados de esta tesis demuestran que los adenovirus oncoliticos expresando BiTEs tienen propiedades que puede superar muchas de las limitaciones de la viroterapia del cáncer, y alienta a continuar su evaluación y desarrollo a nivel clínico.
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Books on the topic "Adenoviruses"

1

1933-, Doerfler Walter, and Böhm P, eds. The Molecular repertoire of adenoviruses. Berlin: Springer-Verlag, 1995.

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1933-, Doerfler Walter, and Böhm Petra, eds. The molecular repertoire of adenoviruses II: Molecular biology of virus-cell interactions. Berlin: Springer-Verlag, 1995.

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S, Di͡a︡chenko N., Smirnov V. V, Instytut mikrobiolohiï i virusolohiï im. D.K. Zabolotnoho., and Semmelweis Orvostudományi Egyetem. Mikrobiológiai Intézet., eds. Adenovirus, kletka, organizm. Kiev: Nauk. dumka, 1988.

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István, Nász. Az adenovírusok pathológiai jelentősége és molekuláris szerkezete: Akadémiai székfoglaló, 1986. február 20. Budapest: Akadémiai Kiadó, 1988.

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E, Tollefson Ann, ed. Adenovirus Methods and Protocols: Volume 1: Adenoviruses, Ad Vectors, Quantitation, and Animal Models. Totowa, NJ: Humana Press, 2007.

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Doerfler, Walter, and Petra Böhm, eds. The Molecular Repertoire of Adenoviruses I. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79496-4.

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Doerfler, Walter, and Petra Böhm, eds. The Molecular Repertoire of Adenoviruses II. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79499-5.

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Doerfler, Walter, and Petra Böhm, eds. The Molecular Repertoire of Adenoviruses III. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79586-2.

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Prem, Seth, ed. Adenoviruses: Basic biology to gene therapy. Austin, TX: R.G. Landes Co., 1999.

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Doerfler, Walter, and Petra Böhm, eds. Adenoviruses: Model and Vectors in Virus-Host Interactions. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05597-7.

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Book chapters on the topic "Adenoviruses"

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Friedman, Allan D., and Sean O. McKenna. "Adenoviruses." In The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes, 127–33. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-391-2_7.

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Coia, John, and Heather Cubie. "Adenoviruses." In The Immunoassay Kit Directory, 629–43. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-009-0359-3_1.

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Lu, Xiaoyan, Amita Joshi, and Phyllis Flomenberg. "Adenoviruses." In Viral Infections of Humans, 99–121. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-1-4899-7448-8_6.

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Andiman, Warren A., and Marie F. Robert. "Adenoviruses." In Virus-Induced Immunosuppression, 59–72. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5583-0_4.

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Foy, Hjordis M. "Adenoviruses." In Viral Infections of Humans, 77–94. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0705-1_3.

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Madeley, Dick, Malik Peiris, and Joyce McQuillin. "Adenoviruses." In Viral and Other Infections of the Human Respiratory Tract, 169–90. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-7930-0_10.

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Foy, Hjordis M. "Adenoviruses." In Viral Infections of Humans, 77–94. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-8138-3_3.

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Foy, Hjordis M. "Adenoviruses." In Viral Infections of Humans, 119–38. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-0036-4_4.

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Ruuskanen, Olli, Jordan P. Metcalf, Matti Waris, and Göran Akusjärvi. "Adenoviruses." In Clinical Virology, 575–97. Washington, DC, USA: ASM Press, 2016. http://dx.doi.org/10.1128/9781555819439.ch27.

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Malanoski, Anthony P., and Baochuan Lin. "Adenoviruses." In Laboratory Models for Foodborne Infections, 13–28. Boca Raton : CRC Press/Taylor & Francis, 2017. | Series: Food microbiology series: CRC Press, 2017. http://dx.doi.org/10.1201/9781315120089-2.

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Conference papers on the topic "Adenoviruses"

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Demina, D. S., S. B. Berdieva, I. D. Osipov, D. E. Maslov, T. V. Komissarova, V. V. Makukha, Yu E. Tomilova, E. F. Agletdinov, and S. V. Netesov. "GENETIC DIVERSITY OF ADENOVIRUSES AMONG ARI PATIENTS OF THE NOVOSIBIRSK CCCH № 3." In OpenBio-2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-242.

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The monitoring of circulating adenoviruses is important for the control of ARI outbreaks and the development of vectors for gene delivery for disease prophylaxis and treatment. However, the diversity of adenoviruses in the Novosibirsk region remained poorly understood. We developed a scheme for genotyping of adenoviruses and analyzed their occurrence among patients of Children’s City Clinical Hospital No. 3. Adenovirus serotypes 1, 2, 3 and 7 were found in 80 % of patients with confirmed adenovirus infection.
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Grigoryan, D. A., I. F. Stetsenko, A. D. Matsvai, and G. A. Shipulin. "DETERMINATION OF THE ANALYTICAL SENSITIVITY OF RESEARCH WITH MULTIPLEX PRIMER PANEL FOR THE DETECTION OF NUCLEIC ACIDS OF RESPIRATORY VIRAL PATHOGENS BY USING HIGH-THROUGHPUT SEQUENCING." In OpenBio-2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-241.

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The research determined the analytical sensitivity of the multiplex primer panel for targeted enrichment of nucleic acids of pathogens of acute respiratory viral diseases. The limit of detection was determined for 23 types of viruses, including influenza viruses, parainfluenza viruses, coronaviruses, adenoviruses, enteroviruses, respiratory syncytial viruses.
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Klein, Sarah R., Hong Jiang, Sujan Piya, Zhimin Lu, Candelaria Gomez-Manzano, and Juan Fueyo. "Abstract B97: The role of JNK isoforms in adenovirus-induced autophagy: Implications for cancer immunotherapy using oncolytic adenoviruses." In Abstracts: AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012; Miami, FL. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tumimm2012-b97.

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Zimmermann, Julia L., Tetsuji Shimizu, Gregor E. Morfill, Veronika Boxhammer, Jurgen Schlegel, Katja Dumler, Anja Wolf, Bernd Gansbacher, and Martina Anton. "Effects of cold atmospheric plasmas on adenoviruses in solution." In 2012 IEEE 39th International Conference on Plasma Sciences (ICOPS). IEEE, 2012. http://dx.doi.org/10.1109/plasma.2012.6383555.

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Leung, Elaine YL, Melanie Weigert, Josephine Walton, Darren Ennis, Dimitris Athineos, Suzanne Dowson, Chris Hansell, Karen Blyth, Gerard Graham, and Iain McNeish. "Abstract A28: Adenoviruses up-regulate IL17F, but not IL17A, and activate NK cells, with potential impact on oncolytic adenovirus efficacy." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 20-23, 2016; Boston, MA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/2326-6074.tumimm16-a28.

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Hoffman, Robert M., Hiroyuki Kishimoto, and Toshiyoshi Fujiwara. "Specific in vivo labeling with GFP retroviruses, lentiviruses, and adenoviruses for imaging." In Biomedical Optics (BiOS) 2008, edited by Alexander P. Savitsky, Robert E. Campbell, and Robert M. Hoffman. SPIE, 2008. http://dx.doi.org/10.1117/12.773308.

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Piya, Sujan, Hong Jiang, Sarah Klein, W. K. Alfred Yung, Raymond Sawaya, Candelaria Gomez-Manzano, and Juan Fueyo. "Abstract 726: Oncolytic adenoviruses modulate autophagy in cancer cells via sumoylation of LC3." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-726.

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Havunen, Riikka, Suvi Parviainen, Mikko Siurala, and Akseli Hemminki. "Abstract B07: Characterization of T-cell therapy enhancing oncolytic adenoviruses with human cytokine expression." In Abstracts: AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/2326-6074.tumimm14-b07.

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Shiina, Marisa, Neda Bagheri, Douglas Lauffenburger, and Wolfgang Michael Korn. "Abstract 3494: Experimentally validated modeling for optimizing therapeutic combinations of oncolytic adenoviruses and MEK inhibitor." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3494.

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Ali, Mehreen, and Donald Seto. "Phylogenetic analysis of hexon and DNA polymerase genes from selected serotypes of human adenoviruses, using bioinformatics tools." In 2011 IEEE 14th International Multitopic Conference (INMIC). IEEE, 2011. http://dx.doi.org/10.1109/inmic.2011.6151453.

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Reports on the topic "Adenoviruses"

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Curiel, David T. Infectivity-Enhanced Adenoviruses for Improved Replicative Oncolysis. Fort Belvoir, VA: Defense Technical Information Center, March 2002. http://dx.doi.org/10.21236/ada405416.

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Curiel, David T. Infectivity-Enhanced Adenoviruses for Improved Replicative Oncolysis. Fort Belvoir, VA: Defense Technical Information Center, March 2003. http://dx.doi.org/10.21236/ada415721.

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Metzgar, David, Miguel Osuna, Samuel Yingst, Magda Rakha, and Kenneth Earhart. Serotype Distribution of Respiratory Adenoviruses in Egypt Determined By Serial Multiplex PCR. Fort Belvoir, VA: Defense Technical Information Center, December 2004. http://dx.doi.org/10.21236/ada430294.

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Pai, Menaka, Benjamin Chan, Nathan M. Stall, Allan Grill, Noah Ivers, Antonina Maltsev, Katherine J. Miller, et al. Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Following Adenovirus Vector COVID-19 Vaccination: Lay Summary. Ontario COVID-19 Science Advisory Table, May 2021. http://dx.doi.org/10.47326/ocsat.2021.02.16.2.0.

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Curiel, David T. Conditionally Replicative Adenovirus for Prostate Cancer Therapy. Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada395216.

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Malasig, Marietta D., Pulak R. Goswami, Leta K. Crawford-Mkisza, David P. Schnurr, and Gregory C. Gray. Simplified Microneutralization Test for Serotyping Adenovirus Isolates. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada408858.

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Balliram, Niranjan. Adenovirus Vaccine Shortfall: Impact on Readiness and Deployability. Fort Belvoir, VA: Defense Technical Information Center, December 2001. http://dx.doi.org/10.21236/ada403017.

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Kaliberov, Sergey A. Therapy of Breast Cancers Using Conditionally Replicating Adenovirus. Fort Belvoir, VA: Defense Technical Information Center, August 2005. http://dx.doi.org/10.21236/ada447528.

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Grubman, Marvin J., Yehuda Stram, Peter W. Mason, and Hagai Yadin. Development of an Empty Viral Capsid Vaccine against Foot and Mouth Disease. United States Department of Agriculture, August 1995. http://dx.doi.org/10.32747/1995.7570568.bard.

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Foot-and-mouth disease (FMD), a highly infectious viral disease of cloven-hoofed animals, is economically the most important disease of domestic animals. Although inactivated FMD vaccines have been succesfully used as part of comprehensive eradication programs in Western Europe, there are a number of concerns about their safety. In this proposal, we have attempted to develop a new generation of FMD vaccines that addresses these concerns. Specifically we have cloned the region of the viral genome coding for the structural proteins and the proteinase responsible for processing of the structural protein precursor into both a DNA vector and a replication-deficient human adenovirus. We have demonstrated the induction of an FMDV-specific immune response and a neutralizing antibody response with the DNA vectors in mice, but preliminary potency and efficacy studies in swine are variable. However, the adenovirus vector induces a significant and long-lived neutralizing antibody response in mice and most importantly a neutralizing and protective response in swine. These results suggest that the empty capsid approach is a potential alternative to the current vaccination strategy.
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Dewhurst, Stephen. New Conditionally Replicating Adenovirus Vectors for Breast Cancer Therapy. Fort Belvoir, VA: Defense Technical Information Center, September 2008. http://dx.doi.org/10.21236/ada502798.

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