Relevant bibliographies by topics / Adenosine-signalling

Contents

  1. Journal articles

Academic literature on the topic 'Adenosine-signalling'

Author: Grafiati
Published: 14 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Adenosine-signalling.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Adenosine-signalling"

1

Fredholm, Bertil B., Giulia Arslan, Bj�rn Kull, Ewa Kontny, and Per Svenningsson. "Adenosine (P1) receptor signalling." Drug Development Research 39, no. 3-4 (1996): 262–68. http://dx.doi.org/10.1002/(sici)1098-2299(199611/12)39:3/4<262::aid-ddr5>3.0.co;2-p.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

CARUSO, M., S. HOLGATE, and R. POLOSA. "Adenosine signalling in airways." Current Opinion in Pharmacology 6, no. 3 (2006): 251–56. http://dx.doi.org/10.1016/j.coph.2006.02.002.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Silva, Luis, Mario Subiabre, Joaquín Araos, et al. "Insulin/adenosine axis linked signalling." Molecular Aspects of Medicine 55 (June 2017): 45–61. http://dx.doi.org/10.1016/j.mam.2016.11.002.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Burnstock, Geoffrey. "Purine and purinergic receptors." Brain and Neuroscience Advances 2 (January 2018): 239821281881749. http://dx.doi.org/10.1177/2398212818817494.

Full text
Abstract:
Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ectonucleotidases. Four subtypes are recognised, A1, A2A, A2B and A3 receptors. P2 receptors are activated by purine and by pyrimidine nucleotides. P2X receptors are ligand-gated ion channel receptors (seven subunits (P2X1-7)), which form trimers as both homomultimers and heteromultimers. P2Y receptors are G protein-coupled receptors (eight subtypes (P2Y1/2/4/6/11/12/13/14)). There is both purinergic short-term signalling and long-term (trophic) signalling. The cloning of P2X-like receptors in primitive invertebrates suggests that adenosine 5′-triphosphate is an early evolutionary extracellular signalling molecule. Selective purinoceptor agonists and antagonists with therapeutic potential have been developed for a wide range of diseases, including thrombosis and stroke, dry eye, atherosclerosis, kidney failure, osteoporosis, bladder incontinence, colitis, neurodegenerative diseases and cancer.
APA, Harvard, Vancouver, ISO, and other styles
5

Liang, Bruce T., Tomasz A. Swierkosz, Howard C. Herrmann, Stephen Kimmel, and Kenneth A. Jacobson. "Adenosine and Ischemic Preconditioning." Current Pharmaceutical Design 5, no. 12 (1999): 1029–41. http://dx.doi.org/10.2174/1381612805666230112212126.

Full text
Abstract:
Adenosine is released in large amounts during myocardial ischemia and is capable of exerting potent cardioprotective effects in the heart. Although these observations on adenosine have been known for a long time, how adenosine acts to achieve its anti-ischemic effect remains incompletely understood. However, recent advances on the chemistry and pharmacology of adenosine receptor ligands have provided important and novel information on the function of adenosine receptor subtypes in the cardiovascular system. The development of model systems for the cardiac actions of adenosine has yielded important insights into its mechanism of action and have begun to elucidate the sequence of signalling events from receptor activation to the actual exertion of its cardioprotective effect. The present review will focus on the adenosine receptors that mediate the potent anti-ischemic effect of adenosine, new ligands at the receptors, potential molecular signalling mechanisms downstream of the receptor, mediators for cardioprotection, and possible clinical applications in cardiovascular disorders.
APA, Harvard, Vancouver, ISO, and other styles
6

Vlajkovic, Srdjan M., and Peter R. Thorne. "Purinergic Signalling in the Cochlea." International Journal of Molecular Sciences 23, no. 23 (2022): 14874. http://dx.doi.org/10.3390/ijms232314874.

Full text
Abstract:
The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues. Two families of P2 receptors, ATP-gated ion channels (P2X receptors) and G protein-coupled P2Y receptors, activate intracellular signalling pathways that regulate cochlear development, homeostasis, sensory transduction, auditory neurotransmission and response to stress. Of particular interest is a purinergic hearing adaptation, which reflects the critical role of the P2X2 receptor in adaptive cochlear response to elevated sound levels. Other P2 receptors are involved in the maturation of neural processes and frequency selectivity refinement in the developing cochlea. Extracellular ATP signalling is regulated by a family of surface-located enzymes collectively known as “ectonucleotidases” that hydrolyse ATP to adenosine. Adenosine is a constitutive cell metabolite with an established role in tissue protection and regeneration. The differential activation of A1 and A2A adenosine receptors defines the cochlear response to injury caused by oxidative stress, inflammation, and activation of apoptotic pathways. A1 receptor agonism, A2A receptor antagonism, and increasing adenosine levels in cochlear fluids all represent promising therapeutic tools for cochlear rescue from injury and prevention of hearing loss.
APA, Harvard, Vancouver, ISO, and other styles
7

Razak, Azlina A., Lopa Leach, and Vera Ralevic. "Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes." Diabetes and Vascular Disease Research 15, no. 6 (2018): 528–40. http://dx.doi.org/10.1177/1479164118790904.

Full text
Abstract:
Background: There is clinical and experimental evidence for altered adenosine signalling in the fetoplacental circulation in pregnancies complicated by diabetes, leading to adenosine accumulation in the placenta. However, the consequence for fetoplacental vasocontractility is unclear. This study examined contractility to adenosine of chorionic vessels from type 1 diabetes mellitus, gestational diabetes mellitus and normal pregnancies. Methods: Chorionic arteries and veins were isolated from human placenta from normal, gestational diabetes mellitus and type 1 diabetes mellitus pregnancies. Isometric tension recording measured responses to adenosine and the thromboxane A2 analogue U46619 (thromboxane A2 mediates fetoplacental vasoconstriction to adenosine). Adenosine and thromboxane prostanoid receptor protein expression was determined by immunoblotting. Results: Adenosine elicited contractions in chorionic arteries and veins which were impaired in both gestational diabetes mellitus and type 1 diabetes mellitus. Contractions to potassium chloride were unchanged. Adenosine A2A and A2B receptor protein levels were not different in gestational diabetes mellitus and normal pregnancies. Contractions to U46619 were unaltered in gestational diabetes mellitus arteries and increased in type 1 diabetes mellitus arteries. Overnight storage of vessels restored contractility to adenosine in gestational diabetes mellitus arteries and normalized contraction to U46619 in type 1 diabetes mellitus arteries. Conclusion: These data are consistent with the concept of aberrant adenosine signalling in diabetes; they show for the first time that this involves impaired adenosine contractility of the fetoplacental vasculature.
APA, Harvard, Vancouver, ISO, and other styles
8

DARCY, P. K., and P. R. FISHER. "Pharmacological evidence for a role for cyclic AMP signalling in Dictyostelium discoideum slug behaviour." Journal of Cell Science 96, no. 4 (1990): 661–67. http://dx.doi.org/10.1242/jcs.96.4.661.

Full text
Abstract:
Phototaxis and thermotaxis by Dictyostelium discoideum slugs on water agar were impaired by the presence in the agar of adenosine, which is a cyclic AMP receptor antagonist in aggregating amoebae. Caffeine, and presumably its analogue theophylline, inhibit cyclic AMP signalling in aggregating amoebae of D. discoideum. Both compounds perturbed slug behaviour in a similar manner to adenosine, as did both ammonium and sulphate ions. (NH4)3SO4 is known to perturb cyclic AMP binding to its receptor, and ammonia is an inhibitor of cyclic AMP signalling in aggregating amoebae. The receptor agonist, cyclic AMPS, disrupted slug organization and impaired phototaxis when present at concentrations high enough to saturate cyclic AMP receptors and compete effectively with endogenous cyclic AMP signals of similar magnitude to those observed during aggregation. Taken together with the considerable circumstantial evidence for cyclic AMP signalling in slugs, these results support a role for cyclic AMP signalling in slug behaviour.
APA, Harvard, Vancouver, ISO, and other styles
9

Przybyła, Tomasz, Monika Sakowicz-Burkiewicz, and Tadeusz Pawełczyk. "Purinergic signalling in B cells." Acta Biochimica Polonica 65, no. 1 (2018): 1–7. http://dx.doi.org/10.18388/abp.2017_1588.

Full text
Abstract:
Adenosine and adenosine triphosphate are involved in purinergic signalling which plays important role in control of immune system. Much data have been obtained regarding impact of purinergic signalling on dendritic cells, macrophages, monocytes and T lymphocytes, however less attention has been paid to purinergic regulation of B cells. This review summarizes present knowledge about ATP- and Ado-dependant signalling in B lymphocytes. Human B cells have been shown to express A2A­-R and A­3-R and each subtype of P2 receptors. Surface of B cells exhibits two antagonistic ectoenzymatic pathways, one relays on constitutive secretion and resynthesis of ATP while the second one depends on degradation of adenosine nucleotides to nucleosides and their subsequent degradation. Inactivated B cells remain under suppressive impact of autocrine and paracrine Ado however activated B lymphocytes increase ATP release and production. ATP protects B cells from suppressive impact of Ado and exerts pro-inflammatory impact on target tissues, it is also involved in IgM release. Ado synthesis however is related with optimal development, implantation and maintenance of plasmocyte population in bone marrow during primary immune response. Moreover Ado plays important role in immunoglobulin class switching which is a key mechanism of humoral immune response. Disruption of purinergic signalling is related with severe clinical implications. Impairment of Ado production in environment of B cells is one of the factors responsible for common variable immunodeficiency. List of evidence suggests also that dysfunction of immune system observed during diabetes may in part depend on disrupted ATP and Ado metabolism in B cells.
APA, Harvard, Vancouver, ISO, and other styles
10

Gracia, Eduard, Kamil Pérez-Capote, Estefanía Moreno, et al. "A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase." Biochemical Journal 435, no. 3 (2011): 701–9. http://dx.doi.org/10.1042/bj20101749.

Full text
Abstract:
A2ARs (adenosine A2A receptors) are highly enriched in the striatum, which is the main motor control CNS (central nervous system) area. BRET (bioluminescence resonance energy transfer) assays showed that A2AR homomers may act as cell-surface ADA (adenosine deaminase; EC 3.5.4.4)-binding proteins. ADA binding affected the quaternary structure of A2ARs present on the cell surface. ADA binding to adenosine A2ARs increased both agonist and antagonist affinity on ligand binding to striatal membranes where these proteins are co-expressed. ADA also increased receptor-mediated ERK1/2 (extracellular-signal-regulated kinase 1/2) phosphorylation. Collectively, the results of the present study show that ADA, apart from regulating the concentration of extracellular adenosine, may behave as an allosteric modulator that markedly enhances ligand affinity and receptor function. This powerful regulation may have implications for the physiology and pharmacology of neuronal A2ARs.
APA, Harvard, Vancouver, ISO, and other styles
More sources
You might also be interested in the extended bibliographies on the topic 'Adenosine-signalling' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography