Relevant bibliographies by topics / Adaptive radiotherapy (ART)

Academic literature on the topic 'Adaptive radiotherapy (ART)'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Adaptive radiotherapy (ART)"

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LEE, Victor Shing-Cheung, Giuseppe SchettIno, and Andrew Nisbet. "UK adaptive radiotherapy practices for head and neck cancer patients." BJR|Open 2, no. 1 (November 2020): 20200051. http://dx.doi.org/10.1259/bjro.20200051.

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Objective: To provide evidence on the extent and manner in which adaptive practices have been employed in the UK and identify the main barriers for the clinical implementation of adaptive radiotherapy (ART) in head and neck (HN) cancer cases. Methods: In December 2019, a Supplementary Material 1, of 23 questions, was sent to all UK radiotherapy centres (67). This covered general information to current ART practices and perceived barriers to implementation. Results: 31 centres responded (46%). 56% responding centres employed ART for between 10 and 20 patients/annum. 96% of respondents were using CBCT either alone or with other modalities for assessing “weight loss” and “shell gap,” which were the main reasons for ART. Adaptation usually occurs at week three or four during the radiotherapy treatment. 25 responding centres used an online image-guided radiotherapy (IGRT) approach and 20 used an offline ad hoc ART approach, either with or without protocol level. Nearly 70% of respondents required 2 to 3 days to create an adaptive plan and 95% used 3–5 mm adaptive planning target volume margins. All centres performed pre-treatment QA. “Limited staff resources” and “lack of clinical relevance” were identified as the two main barriers for ART implementation. Conclusion: There is no consensus in adaptive practice for HN cancer patients across the UK. For those centres not employing ART, similar clinical implementation barriers were identified. Advances in knowledge: An insight into contemporary UK practices of ART for HN cancer patients indicating national guidance for ART implementation for HN cancer patients may be required
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Sonke, J. J. "SP-0436: The concept of adaptive radiotherapy (ART)." Radiotherapy and Oncology 111 (2014): S173. http://dx.doi.org/10.1016/s0167-8140(15)30541-7.

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Bak, Bartosz, Agnieszka Skrobala, Anna Adamska, Joanna Kazmierska, Natalia Jozefacka, Tomasz Piotrowski, and Julian Malicki. "Criteria for Verification and Replanning Based on the Adaptive Radiotherapy Protocol “Best for Adaptive Radiotherapy” in Head and Neck Cancer." Life 12, no. 5 (May 12, 2022): 722. http://dx.doi.org/10.3390/life12050722.

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No clear criteria have yet been established to guide decision-making for patient selection and the optimal timing of adaptive radiotherapy (ART) based on image-guided radiotherapy (IGRT). We have developed a novel protocol—the Best for Adaptive Radiotherapy (B-ART) protocol—to guide patient selection for ART. The aim of the present study is to describe this protocol, to evaluate its validity in patients with head and neck (HN) cancer, and to identify the anatomical and clinical predictors of the need for replanning. We retrospectively evaluated 82 patients with HN cancer who underwent helical tomotherapy (HT) and subsequently required replanning due to soft tissue changes upon daily MVCT. Under the proposed criteria, patients with anatomical changes >3 mm on three to four consecutive scans are candidates for ART. We compared the volumes on the initial CT scan (iCT) and the replanning CT (rCT) scan for the clinical target volumes (CTV1, referring to primary tumor or tumor bed and CTV2, metastatic lymph nodes) and for the parotid glands (PG) and body contour (B-body). The patients were stratified by primary tumor localization, clinical stage, and treatment scheme. The main reasons for replanning were: (1) a planning target volume (PTV) outside the body contour (n = 70; 85.4%), (2) PG shrinkage (n = 69; 84.1%), (3) B-body deviations (n = 69; 84.1%), and (4) setup deviations (n = 40; 48.8%). The replanning decision was made, on average, during the fourth week of treatment (n = 47; 57.3%). The mean reductions in the size of the right and left PG volumes were 6.31 cc (20.9%) and 5.98 cc (20.5%), respectively (p < 0.001). The reduction in PG volume was ≥30% in 30 patients (36.6%). The volume reduction in all of the anatomical structures was statistically significant. Four variables—advanced stage disease (T3–T4), chemoradiation, increased weight loss, and oropharyngeal localization—were significantly associated with the need for ART. The B-ART protocol provides clear criteria to eliminate random errors, and to allow for an early response to relevant changes in target volumes.
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Sale, CA, T. ffrench, and R. Voss. "Personalising margins for bladder radiotherapy." Journal of Radiotherapy in Practice 10, no. 2 (November 12, 2010): 137–40. http://dx.doi.org/10.1017/s1460396910000269.

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AbstractThis patient case study represents the introduction of adaptive radiotherapy (ART) at the Andrew Love Cancer Centre (ALCC) with non-uniform margins for invasive bladder cancer treatment. Invasive bladder cancer has historically had poor local control with radiotherapy treatment; however, with the introduction of cone-beam computer tomography (CBCT) and adaptive treatment, there is potential for improvements in disease control and reduced toxicities.
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Buciuman, Nikolett, and Loredana G. Marcu. "Adaptive Radiotherapy in Head and Neck Cancer Using Volumetric Modulated Arc Therapy." Journal of Personalized Medicine 12, no. 5 (April 21, 2022): 668. http://dx.doi.org/10.3390/jpm12050668.

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A dosimetric study was performed to show the importance of adaptive radiotherapy (ART) for head and neck cancer (HNC) patients using volumetric modulated arc therapy (VMAT). A total of 13 patients with HNC who required replanning during radiotherapy were included in this study. All plans succeeded to achieve the set objectives regarding target volume coverage and organ sparing. All target volumes presented a significant decrease with an average of 76.44 cm3 (p = 0.007) for PTVlow risk, 102.81 cm3 (p = 0.021) for PTVintermediate risk, and 47.10 cm3 (p = 0.003) for PTVhigh risk. Additionally, a positive correlation was found between PTV shrinkage and the number of fractions completed before replanning. Significant volume decrease was also observed for the parotid glands. The ipsilateral parotid decreased in volume by a mean of 3.75 cm3 (14.43%) (p = 0.067), while the contralateral decreased by 4.23 cm3 (13.23%) (p = 0.033). For all analyzed organs, a reduction in the final dose received after replanning was found. Our study showed that ART via rescanning, recontouring, and replanning using VMAT is essential whenever anatomical and positional variations occur. Furthermore, comparison with the literature has confirmed that ART using VMAT offers similar results to ART with intensity modulated radiotherapy.
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Glide-Hurst, C., and I. J. Chetty. "SP-0004 IMAGE-GUIDED ADAPTIVE RADIOTHERAPY (IGART): STATE OF THE ART." Radiotherapy and Oncology 103 (May 2012): S2. http://dx.doi.org/10.1016/s0167-8140(12)70343-2.

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Meldolesi, E., D. Lockman, D. Yan, and A. Martinez. "Geometric Evaluation of Image Guided Adaptive Radiotherapy (ART) for Prostate Cancer." International Journal of Radiation Oncology*Biology*Physics 63 (October 2005): S90—S91. http://dx.doi.org/10.1016/j.ijrobp.2005.07.157.

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Murthy, V. "Bladder preservation with helical tomotherapy-based, image-guided radiotherapy: A clinical study using “plan of the day” adaptive radiotherapy." Journal of Clinical Oncology 29, no. 7_suppl (March 1, 2011): 289. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.289.

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289 Background: This clinical study assessed the potential of helical tomotherapy-based, image-guided radiotherapy (IGRT) to increase the accuracy of bladder irradiation using a plan of the day adaptive radiotherapy (ART) technique. Methods: Ten patients with stage T2b-T4- N0 M0, histologically proven bladder transitional cell carcinoma, who underwent bladder preservation with trimodality therapy in an ongoing trial, are reported. All patients received a dose of 64Gy/32# to the whole bladder. Seven of these also received a simultaneous integrated boost of 68Gy/32 fractions to tumor bed. The ART technique entailed the generation of six planning PTVs and thus six separate IMRT plans for each patient. All patients underwent daily pre and post treatment MVCT imaging to correct for positioning errors, choose the plan of the day, depending on deformation of the bladder, and verify intrafraction filling at the end of treatment. Margins needed to encompass the bladder wall in each direction during radiotherapy was determined in the following three scenarios: (a) centers with availability of daily IGRT and performing ART, (b) centers with IGRT not doing ART, and (c) centers without IGRT using electronic portal imaging for setup. Results: At a median follow-up of 12.2 months, all patients had a complete response in the bladder and one patient had a pelvic nodal recurrence. No patient developed treatment related grade 3 toxicity. Post treatment MVCT scans (n=315) were used to generate margins for centers with varying resources. Overall, the margin needed to encompass the anterior and superior walls 85 to 95% of the time was more than the other walls (Table, margins for six walls in cm). Maximum geographical miss in spite of IGRT was noted for the superior (13.8%) and anterior walls (10.3%). Conclusions: Plan of the day ART is a feasible and promising technique for optimal treatment and dose escalation in bladder cancer. [Table: see text] No significant financial relationships to disclose.
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Schwartz, David L., and Lei Dong. "Adaptive Radiation Therapy for Head and Neck Cancer—Can an Old Goal Evolve into a New Standard?" Journal of Oncology 2011 (2011): 1–13. http://dx.doi.org/10.1155/2011/690595.

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Current head and neck intensity-modulated radiotherapy (IMRT) techniques cause significant toxicity. This may be explained in part by the fact that IMRT cannot compensate for changes in the location of disease and normal anatomy during treatment, leading to exposure of at-risk bystander tissues to higher-than-anticipated doses. Adaptive radiotherapy (ART) is a novel approach to correct for daily tumor and normal tissue variations through online or offline modification of original IMRT target volumes and plans. ART has been discussed on a conceptual level for many years, but technical limitations have hampered its integration into routine care. In this paper, we review the key anatomic, dosimetric, and treatment delivery issues at play in current investigational development of head and neck ART. We also describe pilot findings from initial clinical deployment of head and neck ART, as well as emerging pathways of future research.
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Mulder, Samuel L., Jolien Heukelom, Brigid A. McDonald, Lisanne Van Dijk, Kareem A. Wahid, Keith Sanders, Travis C. Salzillo, Mehdi Hemmati, Andrew Schaefer, and Clifton D. Fuller. "MR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers." Cancers 14, no. 8 (April 10, 2022): 1909. http://dx.doi.org/10.3390/cancers14081909.

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MR-linac devices offer the potential for advancements in radiotherapy (RT) treatment of head and neck cancer (HNC) by using daily MR imaging performed at the time and setup of treatment delivery. This article aims to present a review of current adaptive RT (ART) methods on MR-Linac devices directed towards the sparing of organs at risk (OAR) and a view of future adaptive techniques seeking to improve the therapeutic ratio. This ratio expresses the relationship between the probability of tumor control and the probability of normal tissue damage and is thus an important conceptual metric of success in the sparing of OARs. Increasing spatial conformity of dose distributions to target volume and OARs is an initial step in achieving therapeutic improvements, followed by the use of imaging and clinical biomarkers to inform the clinical decision-making process in an ART paradigm. Pre-clinical and clinical findings support the incorporation of biomarkers into ART protocols and investment into further research to explore imaging biomarkers by taking advantage of the daily MR imaging workflow. A coherent understanding of this road map for RT in HNC is critical for directing future research efforts related to sparing OARs using image-guided radiotherapy (IGRT).
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Books on the topic "Adaptive radiotherapy (ART)"

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Dattoli, Michael. Dynamic Adaptive Radiotherapy for Prostate Cancer: A Primer on DART, the Most Effective State-Of-the-Art Treatment Solution for Select Patients. Independently Published, 2019.

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Book chapters on the topic "Adaptive radiotherapy (ART)"

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Jena, Rajesh, and Peter Harper. "Systemic treatment and radiotherapy." In Oxford Textbook of Medicine, edited by Tim Eisen, 497–504. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0050.

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Cancer therapy is underpinned by a detailed understanding of cancer biology and the complex interaction of tumour and host. Systemic therapies and radiation therapy are being used in many early stage cancers, with a ‘risk adaptive’ approach to maximize the likelihood of uncomplicated tumour cure, both as primary treatment and in the postoperative setting. Targeted therapies have changed the course of many common cancers. Patients with early stage disease benefit through enhanced cure rates, while rational treatment approaches to metastatic disease improve outlook for many patients. Where cancer therapies are given with curative intent, care must be taken to consider long-term toxicities. Systemic therapies may be associated with organ-specific late effects such as dose-dependent cardiac toxicity from anthracycline chemotherapy, lung fibrosis from bleomycin, and sensorineural hearing loss from vincristine. Radiation therapy also carries a risk of tissue damage, dependent on the dose and volume of tissue that is irradiated.
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Lavender, Frances. "Imaging for treatment delivery: Image-guided radiotherapy." In Physics for Clinical Oncology, 163—C10.F5. 2nd ed. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/med/9780198862864.003.0010.

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Abstract This chapter, ‘Imaging for treatment delivery: Image-guided radiotherapy’, discusses the technology and workflows used to verify the geometric accuracy of treatment delivery. A review of the relevant photon interaction processes (photoelectric effect and Compton scattering) precedes a discussion on cone beam CT imaging (CBCT), how this differs from fan-beam CT imaging and how it is used in clinical practice. The importance of patient positioning is highlighted. Other techniques used to improve treatment accuracy, such as gating and tracking are described. The use of adaptive radiotherapy is outlined and the chapter closes with a brief introduction to the possibilities presented by MR-linac technology.
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Conference papers on the topic "Adaptive radiotherapy (ART)"

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Mirestean, Camil Ciprian, Alexandru Dumitru Zara, Roxana Irina Iancu, and Dragos Petru Teodor Iancu. "CT Re-Simulation Based Delta-Radiomics – New Perspectives Beyond Adaptive Radiotherapy (ART)." In 2021 International Conference on e-Health and Bioengineering (EHB). IEEE, 2021. http://dx.doi.org/10.1109/ehb52898.2021.9657643.

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Diniz, João Otávio Bandeira, Aristófanes Corrêa Silva, and Anselmo Cardoso de Paiva. "Methods for segmentation of spinal cord and esophagus in radiotherapy planning computed tomography." In Anais Estendidos da Conference on Graphics, Patterns and Images. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/sibgrapi.est.2021.20009.

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Organs at Risk (OARs) are healthy tissues around cancer that must be preserved in radiotherapy (RT). The spinal cord and esophagus are crucial OARs. In this work, we proposed methods for the segmentation of these OARs from the CT using image processing techniques and deep convolutional neural network (CNN). For spinal cord segmentation, two methods are proposed, the first using techniques such as template matching, superpixel, and CNN. The second method, use adaptive template matching and CNN. In the esophagus segmentation, we proposed a method composed of registration techniques, atlas, pre-processing, U-Net, and post-processing. The methods were applied to 36 planning CT images provided by The Cancer Imaging Archive. The first method for spinal cord segmentation obtained 78.20% Dice. The second method for spinal cord segmentation obtained 81.69% Dice. The esophagus segmentation method obtained an accuracy of 82.15% Dice.
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Lara, Édipo Giovani França, Selene Elifio Esposito, and José Claudio Casali da Rocha. "IMPACT OF PHYSICAL ACTIVITY ON PHYSICAL FITNESS AND BODY COMPOSITION OF WOMEN AFTER BREAST CANCER TREATMENT." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2013.

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Introduction: Much has been discussed about benefits of physical exercise in women who have ended breast cancer treatment, which includes not only the improvement of their quality of life but also a remarkable decreased risk of recurrence. To achieve these benefits, it is important that the parameters for prescribing and monitoring physical activity for this population are well defined, as well as the evaluation of factors that may interfere with the results and the adherence to physical exercises. Objectives: To assess the impact of physical exercise on physical fitness and body composition in women who have ended breast cancer curative treatment and to evaluate the impact of physical exercise on women with binge eating disorder. Methods: This prospective study included 107 women between 18 and 60 years of age shortly after the end of their curative treatment for breast cancer (surgery and/or chemotherapy and/or radiotherapy). The participants, after signing the informed consent form, were motivated to do aerobic exercises, localized muscular strength/resistance, and flexibility exercises. Intervention consisted of sets of physical exercises prescribed to all participants by a physical educator in progressive intensities and volumes over the months, according to their adaptive responses, considering individual capabilities and limitations. All participants were evaluated at entrance for cardiovascular morbidities and oriented how to exercise by their own at their homes. Evaluations including body composition, VO2max, and localized muscle resistance were performed at pre-intervention (basal), after 6 and 9 months of intervention. Results: A total of 78 (72.8%) women adhered to the training program, and 29 (27.2%) chose not to adhere. After 9 months of regular and individualized intervention, adherent women showed significantly better results in all variables of body composition and physical fitness: body mass (-4.38±3.67 kg; p0.05), as well as it was not influenced by breast cancer characteristics (e.g., histology, stage, and molecular subtypes) or treatment (i.e., mastectomy, axillary surgery, chemotherapy, or radiotherapy; p>0.05). Conclusion: Our study shows that individualized programs of self-training sets of physical exercises, remotely guided by a physical education professional, could improve the body composition and physical fitness of women in surveillance after breast cancer, regardless of the history of breast cancer or treatment, showing that it is possible to reduce risk factors associated with breast cancer recurrence and to contribute to a better quality of life for these women.
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