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Dissertations / Theses on the topic 'Adaptive or fitness landscapes'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

SERRELLI, EMANUELE. "Adaptive landscapes: a case study of metaphors, models, and synthesis in evolutionary biology." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19338.

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This dissertation brings a contribution to the philosophical debate on adaptive landscapes, an influent "model" or "metaphor" in evolutionary biology. Some elements of innovation are: the distinction between native and migrant metaphor; a processual and communicational idea on what the Modern Synthesis was, and on what role a metaphor could have played in it; a view (taken by Richard Lewontin) of the disunity and theoretical structure of population genetics; the distinction between “adaptive surfaces” (mainly metaphors) and “combination spaces”, two terms normally conflated in the word “landsc

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2

Thareja, Gaurav. "Mapping the adaptive landscape of cancer cells using a multiomics approach." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL075.

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Le cancer est considéré principalement comme une maladie de la cellule. Certaines cellules cancéreuses acquièrent un avantage adaptatif sous la pression sélective d’un microenvironnement dynamique qui leur permet de surpasser les autres cellules cancéreuses, favorisant leur expansion. Par conséquent, ce travail de thèse vise à cartographier le paysage adaptatif des cellules cancéreuses à l’aide d’une approche multiomique.L’étude d’association pangénomique a montré l’effet des mutations germinales sur les niveaux d’expression 64 protéines cancéreuses listées dans OncoKB et a permis l’identifica

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Meer, Margarita V. 1986. "Exploring fitness landscapes." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/402192.

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Fitness landscape is a concept, which describes the dependence of phenotype on genotype. It was proposed almost a hundred years ago but only recent burst of technologies finally allowed exploring it. We studied different aspects of fitness landscape applying both: computational and experimental approaches. Using mammalian mitochondrial tRNAs we proved that evolution can proceed not only along the ridges of high fitness but also cross the low fitness valleys. Functional analysis of more than 56 000 mutants of green fluorescent protein from Aequorea victoria (avGFP) allowed us to describe

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Di, Pietro Anthony. "Optimising evolutionary strategies for problems with varying noise strength." University of Western Australia. School of Computer Science and Software Engineering, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0210.

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For many real-world applications of evolutionary computation, the fitness function is obscured by random noise. This interferes with the evaluation and selection processes and adversely affects the performance of the algorithm. Noise can be effectively eliminated by averaging a large number of fitness samples for each candidate, but the number of samples used per candidate (the resampling rate) required to achieve this is usually prohibitively large and time-consuming. Hence there is a practical need for algorithms that handle noise without eliminating it. Moreover, the amount of noise (noise

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Karlsen, Ero Stig. "Learning and Evolution in Complex Fitness Landscapes." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-8712.

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<p>The Baldwin effect is the notion that life time adaptation can speed up evolution by 1) identifying good traits and 2) by genetic assimilation inscribing the traits in the population genetically. This thesis investigates the Baldwin effect by giving an introduction to its history, its current status in evolutionary biology and by reviewing some important experiments on the Baldwin effect in artificial life. It is shown that the Baldwin effect is perceived differently in the two fields; in evolutionary biology the phenomenon is surrounded by controversy, while the approach in artificial life

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Herrmann, Sebastian [Verfasser]. "Complex network analysis of fitness landscapes / Sebastian Herrmann." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1122760159/34.

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7

Barnett, Lionel. "Evolutionary search on fitness landscapes with neutral networks." Thesis, University of Sussex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288614.

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Hietpas, Ryan T. "Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/667.

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Evolution is the single cohesive logical framework in which all biological processes may exist simultaneously. Incremental changes in phenotype over imperceptibly large timescales have given rise to the enormous diversity of life we witness on earth both presently and through the natural record. The basic unit of evolution is mutation, and by perturbing biological processes, mutations may alter the fitness of an individual. However, the fitness effect of a mutation is difficult to infer from historical record, and complex to obtain experimentally in an efficient and accurate manner. We have re

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Hietpas, Ryan T. "Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/667.

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Evolution is the single cohesive logical framework in which all biological processes may exist simultaneously. Incremental changes in phenotype over imperceptibly large timescales have given rise to the enormous diversity of life we witness on earth both presently and through the natural record. The basic unit of evolution is mutation, and by perturbing biological processes, mutations may alter the fitness of an individual. However, the fitness effect of a mutation is difficult to infer from historical record, and complex to obtain experimentally in an efficient and accurate manner. We have re

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10

Lu, Guanzhou. "Characterising fitness landscapes with fitness-probability cloud and its applications to algorithm configuration." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4756/.

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Metaheuristics are approximation optimisation techniques widely applied to solve complex optimisation problems. Despite a large number of developed metaheuristic algorithms, a limited amount of work has been done to understand on which kinds of problems the proposed algorithm will perform well or poorly and why. A useful solution to this dilemma is to use fitness landscape analysis to gain an in-depth understanding of which algorithms, or algorithm variants are best suited for solving which kinds of problem instances, even to dynamically determine the best algorithm configuration during differ

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Manukyan, Narine. "Analysis and Modeling of Quality Improvement on Clinical Fitness Landscapes." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/253.

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Widespread unexplained variations in clinical practices and patient outcomes, together with rapidly growing availability of data, suggest major opportunities for improving the quality of medical care. One way that healthcare practitioners try to do that is by participating in organized healthcare quality improvement collaboratives (QICs). In QICs, teams of practitioners from different hospitals exchange information on clinical practices, with the aim of improving health outcomes at their own institutions. However, what works in one hospital may not work in others with different local contexts,

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Vassilev, Vesselin K. "Fitness landscapes and search in the evolutionary design of digital circuits." Thesis, Edinburgh Napier University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322508.

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Merz, Peter. "Memetic algorithms for combinatorial optimization problems fitness landscapes and effective search strategies /." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960860029.

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14

Franke, Jasper [Verfasser], Joachim [Akademischer Betreuer] Krug, and Heiko [Akademischer Betreuer] Rieger. "Statistical topography of fitness landscapes / Jasper Franke. Gutachter: Joachim Krug ; Heiko Rieger." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038224721/34.

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Atkinson, Simon Reay. "Engineering design adaptation fitness in complex adaptive systems." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648674.

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Mlambo, Nolwazi S. X. "Restoring Curio[City] : An Alternative Adaptive Reuse Approach for the derelict Staatsmuseum building throough Landscape Design." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/78705.

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Urban relics, memories of bygone eras, sit desolate and disregarded on the Northern and Southern fringes of the City of Tshwane’s inner-city, also known as Pretoria. Flaking facades, uninviting margins and deflected gazes have resulted in forgotten city narratives, narratives that are immortalised in these monuments. These compositions of culture, and remnants of the past, have fallen prey to the swift progress of the city and have been left forgotten as they retreat into the shadows of their former grandeur. Dwarfed by the bustle of the city and it’s towering urban fabric, a generation unk

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Melnyk, Anita H. "Adaptive landscapes in evolving populations of Pseudomonas fluorescens in simple environments." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28876.

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The adaptive landscape heuristic can be used to answer the question "how predictable is evolution?" because its topology will impact the repeatability of evolution. In my Masters research I addressed this question in two ways: (1) I reviewed empirical adaptive landscape studies in the fields of directed protein evolution and microbial experimental evolution and (2) I performed a selection experiment to characterize adaptive landscape topology by measuring variance in fitness and metabolic phenotype within and among genetically distinct Pseudomonas fluorescens strains in two environments. Empir

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Keller, George Burleigh. "Modeling and Measuring Affordability as Fitness." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77365.

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Affordability of products and services is an economic benefit that should accrue to consumers, whether they are corporations, government agencies or individuals. This concept of affordability goes beyond conventional wisdom that considers affordability as the ability to pay the price of a product or service. This dissertation defines and explores a broader concept of affordability – one of fitness to perform at the level of quality required by the consumer, to perform at that level whenever the product or service is used, and to do so with minimum consumption of resources. This concept of affo

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Neidhart, Johannes [Verfasser], Joachim [Akademischer Betreuer] Krug, and Anton [Akademischer Betreuer] Bovier. "Fitness Landscapes, Adaptation and Sex on the Hypercube / Johannes Neidhart. Gutachter: Joachim Krug ; Anton Bovier." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1064693423/34.

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Kousathanas, Athanasios. "Fitness effects of new mutations and adaptive evolution in house mice." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8250.

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Knowledge of the distribution of fitness effects of new mutations (DFE) can enable us to quantify the amount of genetic change between species that is driven by natural selection and contributes to adaptive evolution. The primary focus of this thesis is the study of methods to infer the DFE and the study of adaptive evolution in the house mouse subspecies Mus musculus castaneus. Firstly, I extended previous methodology to model the DFE based on polymorphism data. Methods that have previously been used to infer the DFE from polymorphism data have relied on the assumption of a unimodal distribut

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Rendel, Mark D. "The evolutionary dynamics of neutral networks : lessons from RNA." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:85107ca7-fada-4582-95e7-17b5bbb038cd.

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The evolutionary options of a population are strongly influenced by the avail- ability of adaptive mutants. In this thesis, I use the concept of neutral networks to show that neutral drift can actually increase the accessibility of adaptive mu- tants, and therefore facilitate adaptive evolutionary change. Neutral networks are groups of unique genotypes which all code for the same phenotype, and are connected by simple point mutations. I calculate the size and shape of the networks in a small but exhaustively enumerated space of RNA genotypes by mapping the sequences to RNA secondary structure

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Gifford, Danna R. "Scaling fitness optima-Studying adaptive evolution with multiple genotypes of Aspergillus nidulans." Thesis, University of Ottawa (Canada), 2011. http://hdl.handle.net/10393/28888.

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Adaptation involves the successive substitution of beneficial mutations by selection, a process known as an adaptive walk. Theoretical models of adaptation have made predictions regarding the properties of adaptive walks, but we know little empirically about how adaptation differs between different genotypes faced with the same environment, knowledge that is critical to a broad understanding of natural adaptation. Furthermore, as the body of theoretical knowledge continues to grow, it is becoming apparent that the conventional model systems used to study adaptation, chiefly single-celled organ

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23

Posani, Lorenzo. "Inference and modeling of biological networks : a statistical-physics approach to neural attractors and protein fitness landscapes." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEE043/document.

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L'avènement récent des procédures expérimentales à haut débit a ouvert une nouvelle ère pour l'étude quantitative des systèmes biologiques. De nos jours, les enregistrements d'électrophysiologie et l'imagerie du calcium permettent l'enregistrement simultané in vivo de centaines à des milliers de neurones. Parallèlement, grâce à des procédures de séquençage automatisées, les bibliothèques de protéines fonctionnelles connues ont été étendues de milliers à des millions en quelques années seulement. L'abondance actuelle de données biologiques ouvre une nouvelle série de défis aux théoriciens. Des

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Kinkaid, Eden. "The architecture of ecology: Systems design for sustainable agricultural landscapes." Ohio University Honors Tutorial College / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1366983104.

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SNYDER, GREGORY HOWARD. "SUSTAINABILITY THROUGH ADAPTIVE REUSE: THE CONVERSION OF INDUSTRIAL BUILDINGS." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1115644591.

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Stultz, Bailey E. "Mnemonic Futures: Exploring the future of place-based memory in post-industrial landscapes." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522340029293925.

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Toubiana, William. "Towards an adaptive and genomic understanding of an exaggerated secondary sexual trait in water striders." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEN058/document.

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Les nombreuses différences qui existent entre les organismes illustrent que le processus de variation est un phénomène universel en biologie. Ces variations sont particulièrement observables chez les espèces sexuées, entre mâles et femelles. Comprendre les différents facteurs biologiques, environnementaux et génétiques, à l'origine de ce dimorphisme sexuel est le cœur de mon sujet de thèse. Pour cela, j’ai établi un nouveau modèle d'étude, l’insecte semi-aquatique Microvelia longipes. Ces insectes ont évolué un dimorphisme sexuel spectaculaire où les mâles présentent une croissance extrême et

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Price, Brian. "The application of modified adaptive landscapes to heuristic modelling of engine concept designs using sparse data." Thesis, Aston University, 2017. http://publications.aston.ac.uk/37624/.

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The automotive internal combustion engine industry operates in a sector that relies on high production volumes for economies of scale, and dedicated production equipment for efficiency of operations and control of quality, yet is subject to the vagaries of a dynamic marketplace, with the need for constant change. These circumstances place pressure on engine designs to be optimised at launch to be competitive and meet market needs, yet be adaptable to uncertain requirements for change over their production life. Engine designers therefore need concept configuration evaluation tools that can ass

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Schinn, Song Min. "Cell-Free Synthesis of Proteins with Unnatural Amino Acids: Exploring Fitness Landscapes, Engineering Membrane Proteins and Expanding the Genetic Code." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6496.

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Unnatural amino acids (uAA) expand the structural and functional possibilities of proteins. Numerous previous studies have demonstrated uAA as a powerful tool for protein engineering, but challenges also remain. Three notable such challenges include: (1) the fitness of uAA-incorporated proteins are difficult to predict and time-consuming to screen with conventional methods, (2) uAA incorporation in difficult-to-express proteins (e.g. membrane proteins such as G-protein coupled receptors) remain challenging, and (3) the incorporation of multiple types of uAA are still limited. In response, we p

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Tierney, Lauren. "An Agent-Based Model of Wildlife Migratory Patterns in Human-Disturbed Landscapes." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19266.

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In recent years, human decision-making has led to significant landscape impacts in the western United States. Specifically, migratory wildlife populations have increasingly been impacted by rural urban development and energy resource development. This research presents the application of agent-based modeling to explore how such impacts influence the characteristics of migratory animal movement, focusing on mule deer (Odocoileus hemionus) in Western Wyoming. This study utilizes complex adaptive systems and agent-based modeling frameworks to increase understanding of migratory patterns in a chan

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Oba, Takuji. "Mathematical foundation of invasion exponents associated with adaptive dynamics." Kyoto University, 2019. http://hdl.handle.net/2433/242439.

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Horstkotte, Tim. "Contested Landscapes : social-ecological interactions between forestry and reindeer husbandry." Doctoral thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66386.

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Throughout northern Fennoscandia, reindeer husbandry is a central part in the cultural heritage of the Sámi people. In its history, Sámi culture and reindeer husbandry have undergone significant adaptations to environmental, social and political challenges. Landscape changes on the winter grazing grounds were mainly driven by resource exploitation, especially by industrialized forestry. Important grazing resources were lost, i.e. terrestrial and arboreal lichens that constitute essential key elements in the herding year. In my thesis, I explore the consequences of these transformations in Swed

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Gaunersdorfer, Andrea, and Cars H. Hommes. "Nonlinear adaptive beliefs and the dynamics of financial markets. The role of the evolutionary fitness measure." SFB Adaptive Information Systems and Modelling in Economics and Management Science, WU Vienna University of Economics and Business, 2001. http://epub.wu.ac.at/434/1/document.pdf.

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We introduce a simple asset pricing model with two types of adaptively learning traders, fundamentalists and technical traders. Traders update their beliefs according to past performance and to market conditions. The model generates endogenous price fluctuations and captures some stylized facts observed in real returns data, such as excess volatility, fat tails of returns distributions, volatility clustering, and long memory. We show that the results are quite robust w.r.t. to different choices for the performance measure. (author's abstract)<br>Series: Report Series SFB "Adaptive Information

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34

Leandersson, Dennis. "The role of copulatory wound infliction on fitness in Drosophila melanogaster." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-84494.

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One of the more fascinating Darwinian puzzles in sexual selection is that of copulatory wounding. For those taxa displaying this behavior, and that does not engage in traumatic insemination, the function of wound infliction during copulation remains unknown. In this study, the intention was to evaluate the purpose of copulatory wounding in Drosophila melanogaster and the consequences it might have for male and female fecundity. The present study measured the size and number of wounds that males from different stocks of Darwinian fitness imposed on females, as well as the copulation duration an

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Nowak, Stefan [Verfasser], Joachim [Akademischer Betreuer] Krug, and Anton [Akademischer Betreuer] Bovier. "Properties of Random Fitness Landscapes and Their Influence on Evolutionary Dynamics. A Journey through the Hypercube / Stefan Nowak. Gutachter: Joachim Krug ; Anton Bovier." Köln : Universitäts- und Stadtbibliothek Köln, 2015. http://d-nb.info/1084169762/34.

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Chan, Yvonne H. "The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins." eScholarship@UMMS, 2011. http://escholarship.umassmed.edu/gsbs_diss/934.

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Sequence divergence of orthologous proteins enables adaptation to a plethora of environmental stresses and promotes evolution of novel functions. As one of the most common motifs in biology capable of diverse enzymatic functions, the TIM barrel represents an ideal model system for mapping the phenotypic manifestations of protein sequence. Limits on evolution imposed by constraints on sequence and structure were investigated using a model TIM barrel protein, indole-3-glycerol phosphate synthase (IGPS). Exploration of fitness landscapes of phylogenetically distant orthologs provides a strategy f

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Chan, Yvonne H. "The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/934.

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Sequence divergence of orthologous proteins enables adaptation to a plethora of environmental stresses and promotes evolution of novel functions. As one of the most common motifs in biology capable of diverse enzymatic functions, the TIM barrel represents an ideal model system for mapping the phenotypic manifestations of protein sequence. Limits on evolution imposed by constraints on sequence and structure were investigated using a model TIM barrel protein, indole-3-glycerol phosphate synthase (IGPS). Exploration of fitness landscapes of phylogenetically distant orthologs provides a strategy f

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Peterson, Michael Ray. "Evolutionary Methodology for Optimization of Image Transforms Subject to Quantization Noise." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1214303970.

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Wenger, Jacob A. "The Adaptive Evolution and Control of Biotypic Virulence in North American SoybeanAphids (Aphis glycines)." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437564434.

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Pace, Bruno. "Rhythms and Evolution: Effects of Timing on Survival." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213241.

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The evolution of metabolism regulation is an intertwined process, where different strategies are constantly being developed towards a cognitive ability to perceive and respond to an environment. Organisms depend on an orchestration of a complex set of chemical reactions: maintaining homeostasis with a changing environment, while simultaneously sending material and energetic resources to where they are needed. The success of an organism requires efficient metabolic regulation, highlighting the connection between evolution, population dynamics and the underlying biochemistry. In this work, I r

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Fritsch, Coralie. "Approches probabilistes et numériques de modèles individus-centrés du chemostat." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20062/document.

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Dans une première partie, nous proposons un nouveau modèle de chemostat dans lequel la population bactérienne est représentée de manière individu-centrée, structurée en masse, et la dynamique du substrat est modélisée par une équation différentielle ordinaire. Nous obtenons un processus markovien que nous décrivons à l'aide de mesures aléatoires. Nous déterminons, sous une certaine renormalisation du processus, un résultat de convergence en loi de ce modèle individu-centré hybride vers la solution d'un système d'équations intégro-différentielles. Dans une seconde partie, nous nous intéressons

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Torrents, Pau. "Farmers' participation in conservation of rural landscapes : A case study of the Menorca Biosphere Reserve (Spain)." Thesis, Stockholms universitet, Stockholm Resilience Centre, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-99774.

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In an European context of agricultural land abandonment, the role of the farming community as landscape stewards is crucial for maintaining the rural landscape as well as the ecosystem services provided by this landscape. Such stewardship is studied here by assessing the participation of the farming community in the management of Menorca Biosphere Reserve, a small Mediterranean island with very well conserved and rich rural landscape which is not escaping this tendency of land abandonment. A survey of 41 farms and interviews with 15 stakeholders were performed in order to assess the role of th

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Köhler, Alexander [Verfasser], and Stephan [Akademischer Betreuer] Becker. "The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness / Alexander Köhler ; Betreuer: Stephan Becker." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1135385483/34.

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Köhler, Alexander Verfasser], and Stephan [Akademischer Betreuer] [Becker. "The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness / Alexander Köhler ; Betreuer: Stephan Becker." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1135385483/34.

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Duncan, Kayleigh E. "Islands of Fitness Compact Genetic Algorithm for Rapid In-Flight Control Learning in a Flapping-Wing Micro Air Vehicle: A Search Space Reduction Approach." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578065644405701.

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Kemble, Henry. "The genotype-phenotype relationship across different scales." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC178/document.

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Avec la révolution moléculaire en biologie, une compréhension des mécanismes de la relation génotype-phénotype est devenue possible. Récemment, les progrès réalisés dans la synthèse et le séquençage de l’ADN ont permis le développement d’expériences de deep-mutational scanning capable de quantifier divers phénotypes pour un ensemble de génotypes sur toute la longueur d’un gène. Ces ensembles de données sont non seulement intéressants en eux-mêmes, mais permettent également de tester de manière rigoureuse des modèles phénotypiques quantitatifs. Nous avons utilisé cette technologie pour caractér

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Matysek, K. "Resilience and Social-Ecological Systems: The UNESCO Biosphere Reserve Program in Australia and Canada." Thesis, Royal Society of Tasmania, University of Tasmania Library Special and Rare Materials Collection, 2009. https://eprints.utas.edu.au/11207/1/01front.pdf.

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United Nations Educational, Scientific and Cultural Organisation (UNESCO) Biosphere Reserves (BRs) provide an example of an integrated sustainability framework that allows for connection between international, national, state / provincial and local levels of conservation and capacitybuilding. The three major functions of a BR are conservation of biodiversity, sustainable development and support for logistics. As coupled social-ecological systems, BRs explicitly acknowledge that human systems and ecological systems are inextricably linked, and have the potential to bridge ecological and s

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Mangueira, Julia Raquel de Sá Abilio. "A regeneração natural como indicadora de conservação, de sustentabilidade e como base do manejo adaptativo de fragmentos florestais remanescentes inseridos em diferentes matrizes agrícolas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/11/11150/tde-04072012-102118/.

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O cenário atual do estado de São Paulo reflete o cenário de degradação observado na Floresta Atlântica do país, onde os remanescentes florestais estão muito fragmentados, degradados e imersos em uma paisagem agrícola, dominada predominantemente por matrizes de cana de açúcar e pastagens. Neste contexto, objetivamos investigar se a regeneração natural da borda de fragmentos florestais tem características distintas nessas duas matrizes agrícolas dominantes. Nossa hipótese foi que de a regeneração natural em fragmentos inseridos em matrizes de cana de açúcar e pastagem são distintas, porque essas

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Notice, Joaquim [UNESP]. "Sistemas socioecológicos, resiliência e as comunidades locais de Cateme: os impactos da mineração do carvão em Moatize, Moçambique, no período de 2010-2014." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152358.

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Cote-Hammarlof, Pamela. "Investigating Evolutionary Innovation in Yeast Heat Shock Protein 90." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1103.

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The Heat Shock Protein 90 (Hsp90) is an essential and highly conserved chaperone that facilitates the maturation of a wide array of client proteins, including many kinases. These clients in turn regulate a wide array of cellular processes, such as signal transduction, and transcriptional reprogramming. As a result, the activity of Hsp90 has the potential to influence physiology, which in turn may influence the ability to adapt to new environments. Previous studies using a deep mutational scanning approach, (EMPIRIC) identified multiple substitutions within a 9 amino acid substrate-binding loop

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