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Coetzee, Liezel. "Adamantane copolymers." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52075.
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Thesis (PhD)--Stellenbosch University, 2001.ENGLISH ABSTRACT: This study concerns the incorporation of adamantane containing monomers 3-(1-adamantyl)-1-propene and 1-(1-adamantyl)-4-vinylbenzene into ethene, propene and higher a-olefins using different catalytic systems. The effect of the incorporation of the adamantane monomer on the physical and thermal properties of the polymers was investigated. A thorough study on the background of adamantane in general, as well as polymerization reactions involving the above-mentioned monomers and a-olefins was done. 3-(1-Adamantyl)-1-propene as well as 1,.(1-adamantyl)-4-vinylbenzene was sucessfully synthesized. The homo polymers of each monomer were made. The above-mentioned monomers were also polymerized: • . 3-( 1-adamantyl)-1-propene with ethene, propene and higher a-olefins, • 1-(1-adamantyl)-4-vinylbenzene with ethene and styrene. The copolymers of 3-(1-adamantyl)-propene as well as 1-(1-adamantyl)- 4-vinylbenzene were characterized as far as possible to show the influence of the incorporation of the adamantane group on the physical and chemical properties of the polymers. A series of 3-phenyl-1-propene copolymers with higher a-olefins were synthesized to compare the influence of the phenyl group to the adamantyl group on the relevant properties of the polymers.
AFRIKAANSE OPSOMMING: Hierdie studie behels die inkorporasie van adamantaan-bevattende monomere, 3-( 1-adamantiel)-1-propeen en 1-(1-adamantiel)-4-vinielbenseen in eteen, propeen en hoër a-olefiene met behulp van verskillende katalitiese sisteme. Die effek wat die inkorporasie van die adamantaan monomeer op die fisiese en chemiese eienskappe van die polimere het, is ondersoek. 'n Deeglike studie van die agtergrond van adamantaan in die geheel, sowel as die polimerisasie reaksies van die bogenoemde monomere met a-olefiene, is gedoen. 3-( 1-Adamantiel)-1-propeen sowel as 1-(1-adamantiel)-4-vinielbenseen is suksesvol berei. Die homopolimere van bogenoemde monomere is gesintetiseer. Bogenoemde monomere is gepolimeriseer: • 3-(1-adamantiel)-1-propeen met eteen, propeen en hoër a-olefiene, • 1-(1-adamantiel)-4-vinielbenseen met eteen en stireen. Die kopolimere van 3-(1-adamantiel)-1-propeen en 1-(1-adamantiel)- 4-vinielbenseen is sover moontlik gekarakteriseer om die invloed van die adamantaan groep op die fisiese en chemiese eienskappe van die polimeer te toon. 'n Reeks kopolimere van 3-(1-feniel)-1-propeen met hoër a-olefiene is gesintetiseer om die verwantskap tussen die invloed van die fenielgroep en die adamantielgroep op die relevante eienskappe van die polimere te toon.
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Floure, Joëlle. "Phospha-adamantane ligands for carbonylation catalysis." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412842.
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Hopewell, Jonathan Paul. "New directions in phospha-adamantane chemistry." Thesis, University of Bristol, 2009. http://hdl.handle.net/1983/b5776f2c-0ac3-4212-8580-3821389bf3d5.
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Makal, Nergis. "1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1321533696.
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Grillaud, Maxime. "Design and synthesis of multifunctional adamantane-based dendrons for biological applications." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF021.
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Les polymères synthétiques tels que les dendrons ou les dendrimères possèdent des propriétés structurales intéressantes. Leur monodispersité et leur synthèse étape par étape permet de contrôler et de caractériser totalement leur structure. De plus, la multivalence offre aux vecteurs une meilleure affinité d’interactions entre plusieurs copies d’un ligand lié au dendron/dendrimère et le récepteur désiré en comparaison au ligand seul. L’adamantane est une molécule rigide et stable dont plusieurs dérivés ont été commercialisés pour des applications thérapeutiques, principalement comme agents antiviraux. De plus, il est possible de le fonctionnaliser sur 4 positions symétriques via des synthèses organiques. Sa conformation 3D permet d’amoindrir les encombrements stériques entre les groupements fonctionnels. Nous avons alors choisi de combiner les propriétés de l’adamantane et des dendrons afin de construire de nouveaux vecteurs synthétiques. Leurs synthèses s’effectuent avec de hauts rendements et chaque nouveau composé a été totalement caractérisé par les différentes techniques d’analyses chimiques et structurales. Les dendrons à base d’adamantane polycationiques non cytotoxiques ont révélé une forte pénétration cellulaire permettant de mieux comprendre les mécanismes d’internalisation des dendrons. Ils ont également été évalués pour la formation de complexes avec un plasmide d’ADN. Des modifications sur leurs structures ont amélioré leur capacité à interagir avec l’acide nucléique grâce à la modification du point focal. Enfin, un peptide thérapeutique aux propriétés protectrices dans le lupus érythémateux disséminé, P140, a été couplé à un dendron à base d’adamantane à 3 branches et nous avons analysé les effets biologiques du trimère en comparaison avec le monomèreDendrons (wedge-shaped dendrimer sections) have been investigated as ideal nanoscale carrier molecules for the delivery of bioactive materials into the cells. Molecular engineering of these hyperbranched, monodisperse, well-defined structures can be easily performed using simple organic synthesis. Multivalency constituted by the multiple surface groups at the periphery of a dendron promotes higher binding affinity for ligand/receptor interactions. Adamantane molecule is a rigid structure consisting of four cyclohexane rings fused in chair conformation. The well-defined 3D conformation, the hydrophobicity and the lipophilicity provide to adamantane-based compounds favorable properties for their transport through biological membranes. In this context, the first part of this work was focused on the design and the synthesis of a novel type of polycationic dendrons based on adamantane, which are able to penetrate into cells without triggering cytotoxic effects. The next study of this Thesis concerned the investigation of our polycationic adamantane-based dendrons for gene delivery. We evaluated the capacity of the dendrons to complex a plasmid DNA. Hydrophobic compounds (biotin and cholesterol) were covalently bound to the focal point of the dendrons via “click” chemistry and the effects of the dendron generation, the peripheral cationic groups, and the hydrophobic modifications on the formation and stability of the complexes were studied. Finally, the dendrons constituted of an adamantane core, a focal point and three arms, were synthetized starting from a multifunctional adamantane derivative. We have coupled P140, a therapeutic peptide with protective properties in systemic lupus erythematosus, to an adamantane-based dendron and we have analyzed the biological effects of the resulting trimer compared to the monomer
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RaviJayaKumar, K., University of Western Sydney, and Faculty of Science and Technology. "Selective oxidation of adamantane by metal complexes." THESIS_FST_XXX_RaviJayaKumar_ K.xml, 1997. http://handle.uws.edu.au:8081/1959.7/369.
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A series of tri-substituted iron and cobalt complexes of the form [M(A)3]n+ were synthesized, and were characterised by UV/Visible absorption and 1H-NMR spectroscopy. The complexes [Co(phen)2(en)]3+ and [Co(bipy)2(en)]3+ have been reported in the literature but 1H-NMR spectroscopy showed that the material produced in both syntheses is [Co(en)3]3+. Spectroscopy further showed that these species cannot be prepared by the literature methods. The complexes were tested in the oxidation of adamantane in the solvents, acetic acid and trifluoroacetic acid and they all oxidised adamantane to a mixture of 1-adamantanol, 1-adamantanol and 2-adamantanone both in the presence and the absence of the oxidant, O2. In all the reactions, however, the yield of conversion was very low. The mechanism for this oxidation was different depending on the presence or absence of O2. In the presence of O2 a catalytic cycle was produced for the oxidation of adamantine. In the oxidation in the presence and absence of O2 there was little variation in activity between the tri-substituted iron and cobalt complexes of 1,10-phenanthroline when compared with the analgous 2,2’-bipyridine complexes. However, the substitution of an ethylenediamine ligand into the co-ordination sphere of cobalt produced significant increase in the activity, although the change was not constant.Master of Science (Hons)
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Ridyard, C. H. "The biotransformation of adamantane and its derivatives." Thesis, University of Exeter, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308344.
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Kadernani, Yakub Esmail Y. E. "Novel adamantane derivatives as multifunctional neuroprotective agents." University of the Western Cape, 2013. http://hdl.handle.net/11394/4256.
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>Magister Scientiae - MScThe pathology of neurodegenerative disorders involves multiple steps, and it is probably for this reason that targeting one particular step in a multi-step process has only yielded limited results. Nitric oxide (NO) is synthesised from L-Arginine by an enzyme known as nitric oxide synthase (NOS). Three isoforms of NOS exist, including endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). In the central nervous system (CNS), nNOS is involved in the synthesis of NO, which is involved in various neurological functions. NO is a free radical and this probably explains why an excess amount of it has been implicated in the development of neurodegenerative disorders. In the CNS, the Nmethyl- D-aspartate (NMDA) receptor in its active state allows the influx of calcium ions which activate nNOS thus increasing the amount of NO and other detrimental reactive nitrogen species within neuronal cells. Calcium entry through voltage-gated calcium channels (VGCC) may also contribute to this. Although calcium ions are important for physiological functioning, an excess is responsible for excitotoxicity, which can ultimately lead to neurodegeneration. Our aim was to synthesise a series of adamantane-derived compounds that act at multiple target sites in the neurodegenerative pathway. By conjugating benzyl and phenylethyl moieties with different functional groups (-H, -NO2, -NH2, -NHC(NH)NH2, -OCH3) to the amantadine structure, we aimed to synthesise compounds that display calcium channel and NMDA receptor (NMDAR) channel inhibition, as well as selective inhibition of nNOS. A series of compounds (-H, -NO2, -NH2, -OCH3) were obtained in yields that varied between 16.5 % and 90.25 %. These novel compounds were tested for calcium influx through VGCC and NMDAR inhibition using synaptoneurosomes isolated from rat brain homogenate against the reference compounds MK-801, NGP1-01, amantadine, memantine and nimodipine. A lack of success with the synthesis of the guanidine compounds prevented the use of the oxyhemoglobin capture assay for the determination of nNOS inhibitory activity of these compounds. The novel synthesised compounds display inhibitory activity towards VGCC and the NMDAR in the micromolar range. Further tests are recommended on compounds SE-1, SE-4, SE-11 and SE-12 as they displayed good inhibitory activity against both NMDAR- as well as ii KCl-mediated calcium influx. These novel compounds may be better therapeutic options than amantadine and memantine as they inhibit both NMDAR and VGCC-mediated calcium influx, whereas amantadine and memantine only inhibit NMDA-mediated calcium influx. These novel adamantane derived compounds may possibly serve as novel leads or potential therapeutic agents for the treatment of neurodegenerative disorders.
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Horkel, Ondřej. "Modifikace polyethylenu reaktivním kompaundováním." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-438897.
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This Master’s thesis deals with the problematics of radically initiated compounding of polyethylene by 1-vinyladamantane. Theoretical part focuses on the theory of grafting processes and how they are influenced by chosen process parameters, as well as the properties of used monomer. In experimental part, two sets of experiments were designed, in both cases the chemicals used were polyethylene LITEN MB 87, (2,5-dimethyl-2,5-bis(tert-butylperoxy) hexane), also called Trigonox 101, as the initiator, and chemicals called Ionol and Irgafos 168 as stabilizers. The experiments were carried out in a Brabender batch mixer, the temperature was 180 – 185 °C, the reaction time was 5 minutes. The analytic methods used to evaluate the prepared samples’ properties were the tensile testing, the Charpy notch test, measuring of the melt flow index, analyzing the torque during kneading and the analysis of infrared spectra of the samples. By carrying out of these experiments it was found that excessive crosslinking was present with mass fraction of initiator being as low as 2 %. It was also concluded that under these conditions the modification does not improve tensile properties of the material, but it does improve the impact strength, albeit slightly. The influence of the modification on flow properties needs to be investigated further. A presence of vinyl groups was observed in infrared spectra, suggesting the presence of ungrafted vinyladamantane.
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Aloisi, Adriano. "Nanoparticles based on different generation adamantane dendrons : design, synthesis and self-assembly studies." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF062.
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L’adamantane est un hydrocarbure polycyclique, rigide et assez encombrant. En médecine, plusieurs dérivés à base d’adamantane ont été développés notamment comme agent antiviraux. Facilement fonctionnalisés, sa conformation 3D permet d’amoindrir les encombrements stériques entre les différents groupements fonctionnels. Nous avons décidé d’utiliser ses propriétés pour concevoir des structures plus complexes, à savoir, des dendrons et des foldamers. Les dendrons sont des polymères synthétiques possédant des propriétés intéressantes. De par leurs tailles, ils sont considérés comme des nanoparticules et possèdent un ciblage passif des cellules cancéreuses. De plus, facilement fonctionnalisés ils peuvent être utilisés comme molécule cargo dans la vectorisation de principes actifs. Outre la vectorisation, les dendrons permettent d’améliorer les propriétés physico-chimiques d’un médicament (absorption, distribution, métabolisme, élimination et toxicité). Nous avons alors choisi de concevoir des dendrons à base d’adamantane. Ces derniers ont la particularité de ne pas posséder d’espaceur entre les molécules d'adamantane se qui les rend hautement rigides. L’analyse par microscopie électronique à transmission de différents dendrons a permis d’étudier leurs morphologies selon leurs fonctionnalisations ainsi que l’effet du solvant, de la concentration et du support sur leurs auto-assemblages. Dans un second temps, nous avons conçu un acide aminé basé sur l’adamantane. Cet acide g-aminé a ensuite été incorporé dans des séquences peptidiques et les effets de l’adamantane sur la structure secondaire des peptides ont été étudiés par dichroïsme circulaireAdamantane is a polycyclic hydrocarbon, rigid and quite bulky. In medicine, several adamantane-based derivatives have been developed especially as antiviral agents. Easily functionalized, its 3D well-defined structure considerably decrease the sterical hindrance between its different functional groups. In this context, we decided to use adamantane to build more complex structures such as dendrons and foldamers. Dendrons are synthetic polymers with interesting properties. Because of their size, they are considered as nanoparticles and possess a passive cancer cell targeting. In addition,they are easily functionalized and can be use as vector of drugs. Indeed, the dendrons improve the physochemical properties of a drug (absorption, distribution, metabolism, elimination and toxicity). We decided to combine adamantane and dendrons to build adamantane-based dendrons. However, these dendrons have the particularity of not having spacer between the adamantane moieties, thus, they are highly rigid. Transmission electron microscopy analysis of the different functionalized dendrons allowed to study their self-assembly capacity and their morphology according to their functional groups,the solvent, the concentration and the support. In a second step, we designed an amino acid based on adamantane. This g-amino acid has been introduced in a peptide backbone using solid phase peptide synthesis. Then, the effects of adamantane onto peptide secondary structures have been studied by circular dichroism
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Yoba-N'goma, Richard Habib Patrick. "The use of adamantane-containing compounds in polymer chemistry /." Link to the online version, 2005. http://hdl.handle.net/10019/1323.
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Yoba, Ngoma Richard Habib Patrick. "The use of adamantane-containing compounds in polymer chemistry." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/1788.
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Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2005.The primary focus of the research was the use of adamantane-containing molecules in polymer science. The research is divided into 2 parts, the first involving the syntheses of a new ligand for use in a metallocene catalyst system. The second part involved the synthesis of new monomers for the use in free radical polymerization systems, In the first part of the research, the synthesis of the ligand, 2-dimethyladamantylethylcyclopentadiene was attempted. This was done via the starting materials adamantylethylbromide and dimethylfulvene. In the first step the adamantylethylbromide was prepared via the tosylation reaction of admantaneethanol. Further, the use of either a Grignard or Barbier reaction to insert the 6,6 dimethylfulvene to yield the final product was attempted. The isolation of the final product could not successfully be completed, even though spectroscopic evidence suggested that the synthesis had been partially succssful. In the second part of the reasearch, the monomers 4-(1-adamantyl)phenolmethacrylate, adamantylmethylacrylate and admantylethylacrylate were synthesized. These monomers were homo-and copolymerized using a controlled radical reaction mechanism (RAFT).
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Moine, Laurence. "Complexes d'inclusion entre un polyélectrolyte dégradable portant des groupes adamantane et un polymère de β-cyclodextrine." Paris 12, 1998. http://www.theses.fr/1998PA120031.
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Un nouveau systeme associatif a ete synthetise a partir du melange de deux polymeres en milieu aqueux : - un copolyester amphiphile derive du poly(acide -malique) contenant une faible proportion de groupes adamantane (substituant hydrophobe possedant une forte constante d'association avec le -cyclodextrine), -un copolymere de -cyclodextrine hydrosoluble obtenu par polycondensation en presence d'epichlorhydrine. La synthese des copolyesters degradables amphiphiles derives du poly(acide -malique), polymere reconnu comme degradable par simple hydrolyse des fonctions esters de la chaine principale, a constitue la premiere etape de cette etude. Ces copolyesters, les poly(acide -malique-co--malate d'adamantyle), ont ete prepares par copolymerisation anionique par ouverture de cycle de deux -lactones--substituees : le malolactonate de benzyle (qui va donner la partie hydrophile du polymere apres deprotection des fonctions benzyliques) et le malolactonate d'adamantyle (partie hydrophobe). Il est important de noter que, malgre l'encombrement sterique du groupe adamantane, le malolactonate d'adamantyle a pu etre, d'une part synthetise et d'autre part polymerise. La formation de complexes d'inclusion entre les groupes adamantane des copolyesters et les cavites du polymere de -cyclodextrine est a l'origine de la compatibilite et de l'association de ces deux copolymeres. De part le caractere polyelectrolyte du poly(acide -malique), les proprietes rheologiques resultantes de cette association dependent fortement du ph : a ph acide(<3), aucune association n'est observee independemment de la concentration, alors qu'une faible augmentation de ph(4) suffit pour accroitre considerablement la viscosite du milieu. Les etudes effectuees en diffusion de la lumiere montrent la formation d'agregats dont les tailles dependent des conditions de ph et de concentration confirmant les etudes viscosimetriques.
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Yvette, Mofenge Opute. "Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance." University of the Western Cape, 2017. http://hdl.handle.net/11394/5930.
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Magister Scientiae - MSc (Pharmaceutical Chemistry)Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to available antimalarial drugs, especially chloroquine (CQ), which was the drug of choice for many years against the blood stage of malaria.
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Foulon, Michel. "Les phases cristallines des adamantanes 1-substitués (plastiques, ordonnées, vitreuses) : thermodynamique, structures, mouvements moléculaires." Lille 1, 1987. http://www.theses.fr/1987LIL10216.
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Etude réalisée plus particulièrement, sur les compos2s fluoro-, chloro-, bromo-, iodo- et cyano-1 adamantane. Mise en évidence par analyse enthalpique différentielle d'une phase "cristal vitreux" pour le cyano-1 adamantane et ses mélanges avec le chloro-1 adamantane. Analyse des mouvements monomoléculaires par relaxation diélectrique, RMN et diffusion incohérente quasi-élastique des neutrons. Mise en évidence du gel du mouvement de basculement moléculaire dans les phases vitreuses par les expériences de relaxation diélectrique
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Matta, Christine Martin Jean-Michel. "Lubrification des couches minces de carbone adamantin non hydrogéné Supraglissement avec les alcools /." [S.l.] : [s.n.], 2009. http://bibli.ec-lyon.fr/exl-doc/cmatta.pdf.
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Zambrano, Damaris E. "Synthesis, coordination chemistry and hydroformylation catalysis with new trioxa-phospha-adamantane ligands." Thesis, University of Bristol, 2003. http://hdl.handle.net/1983/6f36172a-46df-49af-b24b-be7ffe439b77.
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Hayton, Lynda Julie. "Matrix ESR studies of metal atoms with silicon substituted alkenes and related compounds." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325887.
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Denicourt, Thomas. "Études spectroscopique de systèmes désordonnés profondément sous-refroidis." Lille 1, 2002. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2002/50376-2002-357.pdf.
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L'étude des cristaux vitreux et en particulier certains adamantanes substitués comme le Cyanoadamantane (CNa) ou les mélanges CNx-Cl(1-x)ADN, sont susceptibles de nous renseigner sur la nature de la frustration à l'origine de l'état vitreux. Ce travail explique les évolutions structurales et dynamiques observables sur ces composés pendant différentes transformations isothermes de la phase plastique sous-refroidie, montrant clairement que ces systèmes adoptent une succession d'états transitoires métastables avant d'aboutir à l'état ultimement stable. Le second système étudié est un liquide moléculaire vitrifiable très fragile (Triphenyl Phosphite). Il a été récemment découvert l'existence d'une phase apparemment amorphe, distinct du liquide métastable et du verre, et nommé phase glaciale faisant de TPP un exemple de polyamorphisme. Ce travail est une contribution à l'explication de la formation de cet état.
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Nwogu, Nwanyinnaya Akuagwu. "Calix(4)arene, Resorcarene and triaza-adamantane receptors, synthesis, characterisation and cation binding properties." Thesis, University of Surrey, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502677.
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Ennen, Franka. "Protein-Glycopolymer Biohybrid Structures Based on Molecular Recognition Processes for Biomedical Applications." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-158789.
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The design of versatile biohybrid nanosized materials has revealed itself as a promising avenue towards biomedical applications in today´s life sciences. In this regard the combination of components of synthetic and natural origin facilitates an applicability which is supposed to be far beyond the sum of their single components. These biohybrid structures (BHS) can be built by a huge variety of building blocks including solid or soft nanoparticles, peptides/proteins, polynucleotides or low molecular weight drugs. Along with the latter the attachment of biologically active entities or imaging moieties, e. g. enzymes, fluorescence markers or targeting motifs display thereby a key step towards the development of carrier systems for drug delivery purposes.
Among the soft nanoparticles especially dendritic polymers such as perfectly branched dendrimers or hyperbranched polymers are considered as ideal building blocks, since they allow an easy tailoring of crucial properties such as solubility, biocompatibility or bioactivity by means of surface functionalization. Especially in the field of targeted drug delivery the crucial role of sizes and size distributions of carriers has been highlighted recently, since it critically influences important factors such as circulation time or biodistribution within the body.
The ability of avidin to form high molecular weight associates with biotinylated macromolecules as well as its inherent properties makes it a suitable candidate for passive and active targeting in combination with biotinylated (bio-)polymers. Furthermore, along with the covalent attachment of bioactive moieties, non-covalent attachment is a frequently used approach, because it is assumed to only require stoichiometric mixing. In context of the latter molecular recognition processes such as the avidin-biotin, β-cyclodextrin-adamantane or Ni(II)-NTA-histidine-tag interactions have shown to be fruitful strategies for the attachment of bioactive entities.
The overall aim of this work was to fabricate BHS based on dendritic glycopolymers with varied sizes in the nano- and micrometer range as models for biomedical applications e. g. carriers for drug delivery. Therefore the molecular recognition of avidin with biotin derivatives and β-cyclodextrin with adamantane derivatives was utilized in order to tailor final sizes, functionality or catalytic activity of those BHS.
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Veselý, Dominik. "Syntéza pokročilých intermediátov na báze para-bis (2-thienyl) fenylenu so zabudovaným adamantanovým skeletom. Vplyv intramolekulárnych vodíkových väzieb na fotoizomerizáciu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444541.
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This diploma thesis describes study and onward synthesis of advanced organic structures with potential application in the field of organic electronics and, in particular, molecular photoswitches. In the theoretical part of the thesis are closely described most commonly used conventional molecular photoswitches with special attention to the influence of the structural modifications on properties and applications of the given derivatives. Next passage is dedicated to study of donor-acceptor systems, as fundamental building blocks for synthesis of advanced derivatives. The possibilities of derivatization with a goal of improving the physicochemical properties of these compounds are also discussed. In the final chapter are proposed modern synthetic methods for preparation of novel materials for organic electronics. This section is connected with an experimental part, where are designed and consequently synthesised 4 novel imine derivatives with dodecyl and adamantyl-ethyl side chain.
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Magnier, Dominique. "Structure et thermodynamique de cristaux mixtes de cyano et chloroadamantane." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37599329s.
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Garcia, Adriana. "Complexos de ouro(I) derivados do adamantano: síntese, atividade citotóxica e potencial de inibição da tiorredoxina redutase." Universidade Federal de Juiz de Fora, 2015. https://repositorio.ufjf.br/jspui/handle/ufjf/313.
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Este trabalho descreve a síntese, caracterização, atividade citotóxica e potencial de inibição da enzima tiorredoxina redutase (TrxR) de quatro novos complexos de ouro(I) derivados do adamantano com 1,3,4-oxadiazol ou 1,3-tiazolidina-2-tiona e alquil ou aril fosfinas. Os compostos foram avaliados quanto à citotoxicidade em três linhagens de células tumorais e uma linhagem normal, sendo determinada a concentração inibitória de cinquenta por cento da viabilidade celular (CI50) e o índice de seletividade (IS). Uma das mais importantes aplicações de complexos metálicos na clínica médica é no tratamento do câncer como é o caso da Cisplatina [(cis-diamindicloroplatina(II)] e seus derivados. Entretanto, existem problemas associados ao seu uso, especialmente a resistência celular desenvolvida por alguns tipos de tumor e os graves efeitos colaterais, que geram uma demanda por compostos mais ativos contra o câncer e menos tóxicos para o paciente. Dentro deste contexto, a busca por complexos contendo diferentes metais que possibilitem novos alvos celulares surgiu como forma de contornar tais problemas. A ação de complexos com platina ocorre preferencialmente sobre o DNA enquanto a ação do ouro está relacionada à inibição da enzima TrxR que participa do balanço redox intracelular. Com o intuito de potencializar a ação dos complexos de ouro(I) selecionamos os ligantes derivados do adamantano com anel heterocíclico oxadiazol ou tiazolidina e fosfinas (alifáticas ou aromáticas) que estão presentes em substâncias bioativas. Os compostos sintetizados foram caracterizados por CHN, RMN 1H e 13C, IV, Raman, TG além de difração de raios X por monocristal no caso dos ligantes e do complexo 1 {trifenilfosfino[5-adamantil-1,3,4-oxadiazol-2-tiolato(κS)]ouro(I)}. Todos os complexos foram mais ativos sobre as células tumorais que os ligantes livres e foram mais eficientes e seletivos do que a Cisplatina para a linhagem de células de melanoma (B16-F10). O complexo 4 {Cloreto de trietilfosfino[(metil-1-adamantano)1,3-tiazolidina-2- tiona(κS)]ouro(I)} apresentou valores de CI50 próximos a Auranofina [2,3,4,6-tetra-o-acetil-1- tio-β-D-glicopiranosato-trietilfosfinouro(I)] e maior seletividade. Quanto a capacidade de inibição da enzima TrxR, os complexos com trietilfosfina foram mais eficientes, alcançando porcentagem de inibição próxima a da Auranofina. Notamos uma relação entre a capacidade de inibição da TrxR e a citotoxicidade, o que sugere o mecanismo de ação destes compostos de ouro via inativação da enzima. Dessa forma, o presente trabalho apresenta uma importante contribuição para a química de coordenação dos complexos de ouro(I).
This work describes the synthesis, characterization, cytotoxic activity and potential inhibition of thioredoxin reductase (TrxR) of four new gold (I) complexes with novel ligands derived from adamantine, 1,3,4-oxadiazole or 1,3-thiazolidine-2-thionering and alkyl or aryl phosphines. The cytotoxicity of compounds was investigated in three tumor cell lines and one normal cell to determine the inhibitory concentration of fifty percent of cell viability (IC50) and selectivity index (SI). One of the most important applications for metal complexes such as Cisplatin [cis-diamindichloroplatinum(II)] and derivatives is in cancer treatment. However, there are several problems associated with their use, especially cellular resistance, developed by some tumor cells, and serious side effects. Those problems create a demand for new compounds more active against cancer and less toxic to patient. In this context, the search for complexes with other metals that present different cellular targets appeared to circumvent such problems. The action of platinum complexes occurs preferentially on DNA while the gold action is related to the inhibition of the enzyme TrxR which participates in intracellular redox balance. To enhance biological activity of gold complexes we prepared ligands containing adamantane with heterocyclic ring oxadiazole or thiazolidine and phosphines (trimethyl or triphenyl) which are present in bioactive substances. The synthesized compounds were characterized by CHN, 1H and 13C NMR, IR, Raman, TG and X-ray diffraction for ligands and complex 1 {triphenylphosphin[5-adamantyl-1,3,4-oxadiazole-2- thiolate(κS)]gold(I)}. All complexes were more active against tumor cells compared to the free ligands and more efficient and selective than cisplatin for melanoma cell line (B16-F10). The complex 4 {Triethylphosphine chloride[(metyl-1-adamantane)1,3-thiazolidine-2- thione(κS)]gold(I)} showed IC50 values near Auranofin [2,3,4,6-tetra-o-acetyl-1-thio-β-Dglycopyranosate- trietylphosphingold(I)] and higher selectivity. The ability to inhibit TrxR was most relevant for the complexes with ethyl phosphine reaching the inhibition promoted by Auranofin. We have observed a relationship among the capacity to inhibit TrxR, structure and cytotoxicity which contributes to confirm the mechanism of action for gold compounds. Thus, this study is an important contribution to the coordination chemistry of gold(I) complexes.
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Barbosa, Gisele. "Síntese de derivados adamantóides diaminados e amino álcoois, potenciais agentes farmacológicos." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/600.
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CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Compostos adamantóides têm sido alvo de interesse desde a virada do século 20, devido a sua analogia com a estrutura do diamante. A estrutura única do adamantano é refletida em suas propriedades físicas e químicas altamente diferenciadas, que podem ter muitas aplicações, incluindo a concepção de medicamentos e carreação de fármacos. Estes estão presentes numa grande variedade de compostos bioativos, mostrando atividade contra alguns agentes infecciosos e em muitos distúrbios fisiológicos. Juntamente com as aminas e, principalmente, as poliaminas que são substâncias que ocorrem amplamente em materiais biológicos podendo estar envolvidas em muitos aspectos como crescimento, divisão e diferenciação celular, os compostos adamantóides são considerados um alvo potencial para a quimioterapia de várias doenças, principalmente as infecciosas. Nesse contexto, esse trabalho tem como proposta a preparação de novos derivados adamantóides diaminados e amino álcoois, que sejam potenciais agentes farmacológicos. Para obtenção dos compostos almejados, o 1- adamantano metanol teve o grupo hidroxila transformado em um melhor grupo abandonador e em seguida substituído por diferentes aminas e amino álcoois. E, para a síntese dos derivados da 2-adamantanona foi realizada a aminação redutiva da mesma com as diaminas e amino álcoois utilizados. Obteve-se 19 compostos, sendo 12 inéditos, os quais foram caracterizados por espectroscopia na região do Infravermelho e Ressonância magnética nuclear de 1H e 13C. Foram realizados diferentes ensaios biológicos e o composto 7 apresentou maior destaque nos testes realizados.
Adamantoids compounds have been the subject of interest since the turn of the 20th century due to its analogy with the diamond structure. The unique structure of adamantane is reflected in their highly differing physical and chemical properties, which can have many applications, including drug design and drug delivery, and is present in a variety of bioactive compounds showing activity against several infectious agents, and in many physiological disorders. Along with amines and especially polyamines which are substances that widely occur in biological material may be involved in many aspects such as growth, cell division and differentiation been considered a potential target for chemotherapy for several, especially infectious diseases. In this context, this paper aims at the preparation of new diamines and amino alcohols adamantoids derivatives, which are potential pharmacological agents. To obtain the desired compounds, 1-adamantane methanol has the hydroxyl group converted into a better leaving group, and then replaced by different amines and amino alcohols. For the synthesis of the 2- adamantanone derivatives it was employed reductive amination with diamines and amino alcohols followed by the reduction with NaBH3CN. It was prepared in this work 19 compounds, including 12 previously unpublished, which were characterized by infrared spectroscopy and 1H and 13C nuclear magnetic resonance. Preliminary biological evaluations were performed and compound 7 showed the best activity on the realized biological assays.
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Jančík, Ján. "Syntéza a charakterizace pokročilých molekul s implementovaným adamantanovým skeletem." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-376807.
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This diploma thesis describes synthetic approach and characterization of advanced molecules with implemented adamantane skeleton and perspective use in attractive field of organic electronics. Three of four prepared molecules based on para-bis(2-thienyl)phenylene are original and totally new, and there were performed different synthetic approaches with comparison of yield, ecological and financial impact. Study of microwave synthetic approach was provided for cross-coupling reactions on para-bis(2-thienyl)phenylene skeleton. For all molecules were used ethyladamantyl and methyladamantyl substituents. Also, two completely new molecules based on 2,2':5',2''-terthiophene with ethyladamantyl and methyladamantyl substituents were prepared. In the next part were prepared new dimer structures of adamantane with possible application on field of polymers as bridge molecules. In the thesis were also made series of experiments for preparation of tetrasubstituted adamantane molecules, and for optimisation of preparation of spiroadamantane systems.
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Karakasyan, Carole. "Fonctionnalisation de surfaces par l'intermédiaire du couple adamantane/β-cyclodextrine : application du procédé pour l'élaboration d'un immunocapteur." Paris 12, 2005. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990002281480204611&vid=upec.
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Le phénomène d’association aux interfaces par formation de complexes d’inclusion entre des molécules de β-cyclodextrine (β-CD) et des polymères amphiphiles modifiés par des groupements adamantyle a été mis en jeu pour la fonctionnalisation de surfaces. Ce procédé a ensuite été appliqué à l’élaboration d’un immunocapteur. Dans la première partie de ce travail, des études théoriques menées par électrophorèse capillaire d’affinité (ACE) et par chromatographie liquide à haute performance (CLHP) ont permis de déterminer les constantes d’affinité en solution entre des molécules de β-CD et des polymères modèles de poly(éthylène glycol)s modifiés par des groupements hydrophobes adamantyle. D’autre part, l’utilisation d’un support chromatographique à base de β-CD a permis d’accéder aux constantes aux interfaces. Dans une seconde partie, la faisabilité d’un procédé de fonctionnalisation d’une surface par l’intermédiaire de complexes d’inclusion a été démontrée par CLHP par l’élaboration de supports chromatographiques de fonctionnalités variables. Pour cela, un polymère de β-CD a été greffé sur de la silice diol puis la fixation sur le support de dextranes modifiés par des groupements adamantyle et des groupements de fonctionnalités diverses (ioniques, hydrophobes ou molécules biologiques) a été étudiée. Les propriétés de surface des supports ainsi obtenus ont été révélées par l’étude de la rétention de protéines en fonction de la composition de la phase mobile ou par la capture d’un antigène dans le cas particulier de la phase stationnaire modifiée par des anticorps. Enfin, la formation de complexes d’inclusion aux interfaces a été mise à profit pour la réalisation d’immunocapteurs. L’élaboration de ces systèmes analytiques a été suivie en temps réel par résonance des plasmons de surface (RPS). .The association between molecules of β-cyclodextrin (β-CD) and amphiphilic adamantyl-modified polymers by formation of inclusion complexes at solid/liquid interfaces was used for the functionalization of surfaces and the elaboration of an immunosensor. At first, theoretical studies led to the determination of affinity constants in solution and at interfaces between molecules of β-CD and model polymers bearing adamantyl groups. Then, the method used for the functionalization of surfaces by formation of inclusion complexes was validated by the modification of surface properties of silica particles and by the elaboration of chromatographic supports of various functionalities. At least, the formation of inclusion complexes at interfaces was used for the elaboration of β-lactoglobulin-coated immunosensors. The sensors prepared following this procedure permitted the specific and reproducible detection of the corresponding antibodies
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Decressain, Régis. "Les relaxations dipolaires croisées dans les cristaux plastiques : application au fluoroadamantane." Lille 1, 1986. http://www.theses.fr/1986LIL10014.
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Etude par RMN des mouvements moléculaires par utilisation simultanée des temps de relaxation des spins différents. Calcul des fonctions d'autocorrélation, en relation avec la structure, dans le cas de réorientations cubiques et de rotations uniaxiales simultanées
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Hu, Wenting. "Stimuli responsive cyclodextrin-based supramolecular polymers." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS133.
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Les travaux précédents du laboratoire ont mis au point un dérivé ponté de β-cyclodextrine capable de former un polymère supramoléculaire. Il a été montré que le système possédait de bonnes performances en compaction de l'ADN et pour la transfection de siARN. L'obtention d’un degré de polymérisation plus élevé du polymère supramoléculaire, qui permettrai une plus grande capacité dans le domaine de la condensation et de la délivrance de gènes, est le sujet de ce travail. Pour atteindre cet objectif, sur la base de la méthode de polyfonctionnalisation des cyclodextrines mise au point au laboratoire et de la stratégie visant à éviter le phénomène d’auto-inclusion, un système β-cyclodextrine/adamantane est conçu: (1) l’introduction du groupe adamantyle situé au centre de la cavité pour inclusion un meilleur assemblage; (2) l'introdution d'un groupement cationique portant plusieurs charges positives pour l'interaction avec les acides nucléiques. Une molécule de sucre est également utilisée pour la construction d'un système supramoléculaire, qui devrait lui conférer des fonctions plus complexes pour imiter les macromolécules biologiques. Les comportements d’autoassemblage des trois composés ont été caractérisés par RMN-1H, RMN-ROESY, RMN-DOSY, ITC, viscosité et DLS. Nous devons maintenant mener une étude d'interaction avec les acides nucléiques. De façon surprenante l’auto-inclusion est toujours obtenue malgré le pontage. Une série d'expériences sur l'effet du temps, de la concentration, de la température et du pH sont effectuées par RMN-1H afin d'examiner les facteurs influant l'auto-inclusion et l'agrégation par rapport à la formation de polymères supramoléculairesPrevious work developed bridged β-cyclodextrin derivative which are capable of formation supramolecular polymer. Significantly, it showed a good performance in DNA compaction and cooperative interaction with siRNA. Obtaining higher degree of polymerization of supramolecular polymer, allowing further capability in the gene condensation and gene delivery field, is the subject of thesis work. To achieve this target, using polyfunctionalisation of cyclodextrins developed in the laboratory and the previous strategy to avoid the self-inclusion phenomenon, the β-cyclodextrin/adamantane system is designed: (1) to introduce an adamantyl group located in the center of the cavity to trigger a higher level of the assembly; (2) to introduce cationic groups carrying several positive charge for the interaction with the gene. In addition, small sugar molecule is also employed to construct supramolecular dynamic system, which is expected to endow more complex functions to mimic biological macromolecules. These three β-cyclodextrin derivatives overcome the problem of the formation of self-inclusion in aqueous solution. The self-assembly of these compounds have been characterized by 1H-NMR, NMR-ROESY, NMR-DOSY, ITC, viscosity and DLS. We now have to operate the transfection study to confirm the ability of our designed molecules to act as transfecting agents. Surprisingly, the self-inclusion compound is still obtained even with bridging. A series of experiments: time effect, concentration effect, temperature effect, and pH effect were studied by 1H-NMR, in order to examine the influence of these factors on self-inclusion and aggregation versus supramolecular polymer formation
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Cigánek, Martin. "Modifikace organických vysoce výkonných pigmentů pro aplikace v organické elektronice." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-433285.
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Dizertační práce pojednává o studiu, syntéze a chemické derivatizaci molekul spadajících do skupiny organických vysoce výkonných pigmentů a jejich potenciálním uplatnění v oblastech organické elektroniky. Teoretická část práce je zaměřena na nejnovější trendy v dané oblasti, a to jak z aplikačního potenciálu konkrétních derivátů, tak z pohledu syntetických možností a jejich strukturálních derivatizací. V experimentální části je pak podrobně popsána příprava pestré škály intermediátů a výsledných produktů, zahrnujících deriváty diketopyrrolopyrrolů (DPP), benzodifuranonu (BDF), epindolidionu (EP), naphthyridinedionu (NTD) a polymeru na bázi thiofenu (PT). Celkově bylo nasyntetizováno 103 molekul, přičemž 49 tvořily výsledné produkty, z nichž 27 bylo zcela nových, dosud nepublikovaných. Hlavním motivem derivatizace molekul pigmentů je zde inkorporace derivátů adamantanu do finálních struktur. V další části práce jsou blíže diskutovány jednotlivé chemické modifikace vedoucí k výsledným produktům. Na sérii N,N'-; N,O'- a O,O'-substituovaných derivátů DPP je popsána komplexní studie vlivu charakteru alkylových řetězců a také pozice jejich navázání v molekule DPP, a to nejen na selektivitu reakce, ale rovněž na optické i termické vlastnosti syntetizovaných produktů.
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Laamyem, Abdessadeq. "Chloroadamantane-bromoadamantane : deux exemples de transitions de phase ordre-désordre." Lille 1, 1986. http://www.theses.fr/1986LIL10077.
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La mesure des intensités intégrées des raies Raman dues aux vibrations internes dans la phase plastique du chloroadamantane permet de confirmer la valeur du coefficient A(4)(11) donnée par diffraction Ax. Mise en évidence de la phase IV du bromoadamentane par spectrométrie Raman. Les phases III et II ordonnée et semi-ordonnée sont étudiées par diffraction Rx et spectrométrie Raman et la transition III-II à 279 K est de type ordre-désordre
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Wiacek, Kevin John. "SYNTHESIS AND ELECTRICAL PROPERTIES OF FLUORENYL POLYESTERS INCORPORATING DIAMOND FRAGMENTS." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1183079024.
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Matta, Christine. "Lubrification des couches minces de carbone adamantin non hydrogéné : Supraglissement avec les alcools." Ecully, Ecole centrale de Lyon, 2008. http://www.theses.fr/2008ECDL0006.
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Ben, Hassine Bacem. "Polymorphisme, dynamique et transitions de phases dans les dérivés de l'adamantane." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0056/document.
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Ce travail concerne l'étude du polymorphisme, de la dynamique et des transitions de phases de cinq dérivés de l' adamantane : 1-fluoroadamantane, 1-adamantaneméthanol, 1,3-diméthyladamantane, 1,3-dibromoadamantane et 1,3-adamantanediol.Les diagrammes pression -température ont été établis pour la majorité de ces dérivés. Ces matériaux peuvent présenter une, voire plusieurs, transitions de phases. Le 1-fluoroadamantane, le 1,3-diméthyladamantane et le 1,3-adamantanediol possèdent une phase plastique avant fusion.Les structures de toutes les phases non plastiques ont été résolues principalement à partir de diagrammes de diffraction des rayons X sur poudre. Celles du 1,3-dibromoadamantane, et du 1,3-diméthyladamantane sont ordonnées. L'existence d'un désordre statistique concernant l'occupation du site d'un atome a été montrée pour les autres phases. L'atome de fluor du 1-fluoroadamantane peut occuper 4 (phases III et II) ou 8 sites (phase I). Dans le cas de la phase I du 1-adamantaneméthanol et de la phase II du 1,3-adamantanediol, la symétrie du réseau implique que l'atome d'hydrogène lié à l'oxygène se partage sur deux sites.Deux mécanismes de transition ordre-désordre par une relation de groupe à sous-groupe ont été montrés pour le cas du 1-fluoroadamantane et du 1-adamantaneméthanol en utilisant des techniques expérimentales complémentaires (DSC, DRX, RAMAN, GSH...). Le paramètre d'ordre de la transition résulte de la variation continue en fonction de la température de l'inclinaison du dipôle C-F pour le premier et, de la diminution de l'angle beta de la phase monoclinique jusqu'à 90°, pour le second.La dynamique moléculaire dans le cas du 1-fluoroadamantane a été étudiée par spectroscopie diélectrique. L'existence d'une double relaxation associée à deux mouvements de réorientations compatibles avec le réseau et la symétrie a été révéléeThis work deals with the study of the polymorphism, dynamics and phases transitions of five adamantane derivatives : 1-fluoroadamantane, 1-adamantanemethanol, 1,3-dimethyladamantane, 1,3-dibromoadamantane and 1,3-adamantanediol.Pressure-Temperature phase diagrams have been established for the majority of these derivatives. These materials may have one or more phase transitions. Plastic phases are observed before melting for 1-fluoroadamantane, 1,3-dimethyladamantane and 1,3-adamantanediol.The structures of all the non plastic phases have been solved, mainly from powder X-ray diffraction patterns. It is shown that 1,3-dibromoadamantane and 1,3-dimethyladamantane structures are ordered. Statistical disorder concerning the occupation of the site of one atom has been revealed in the other structures. The fluorine atom in 1-fluoroadamantane has four (phase III and II) or eight (phase I) possible equivalent sites. Due to the crystal symmetry of 1-adamantanemethanol (phase I ) and 1,3-adamantanediol (phase II), the hydrogen atom related to the oxygen atom is spitted on two sites.Two mechanisms of continuous order-disorder transitions through a group-subgroup relationship have been shown for the case of 1-fluoroadamantane and 1-adamantanemethanol using complementary experimental techniques (DSC, XRD, RAMAN, SHG ...). The order parameter of the transition results, by a continuous variation of the orientation of the C-F dipole for the first and, for the second, the continuous variation of the beta monoclinic angle down to 90°.Molecular dynamics in the case of 1-fluoroadamantane has been studied using dielectric spectroscopy. We have highlighted the existence of a double relaxation associated with two movements of reorientations compatible with the network and the symmetry
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Svítil, Jan. "Modifikace polypropylenu reaktivním kompaundováním." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-438898.
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Knowledge of radical initiated grafting was summarized in theoretical part. It also contains a part about adamantane, its derivatives and a study of their use in polymer chemistry. In experimental part radical grafted polypropylene was prepared in batch mixer Brabender at 185 and 195 °C, 40 RPM and reaction time 5 min. Initiator 2,5-dimethyl-2,5-bis(tert-buthylperoxy)hexane (Trigonox 101) in concentrations between 0,2 – 4 wt % was used. 1-vinyladamantane was chosen as a monomer and its concetration ranged from 0,75 to 2,24 wt %. Mechanical properties of prepared samples were tested. Sample with content of initiator 0,2 wt % and monomer 1,4 wt % showed increase in notch toughness by 56,3 %, strength by 8,7 %, ductility by 11,5 % and decrease in MFR (230 °C; 2,16 kg) by 29,7 %. Values of torque indicated grafting reactions which couldn’t be proven by use of FTIR method so more suitable methods have been proposed.
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Pugh, Robert Ian. "Phospha-adamantanes : a new class of bulky alkyl phosphine ligands." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/45a5eb1f-2213-49d6-a041-f5e597fa3469.
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Ngilirabanga, Jean Baptiste. "A supramolecular derivatised study of BIS(Adamantan-1- Aminium) carbonate." University of the Western Cape, 2014. http://hdl.handle.net/11394/4188.
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Magister Pharmaceuticae - MPharmIn this study, new solid supramolecular derivatised forms of bis(adamantine-1-aminium) carbonate (ADTCO3) were prepared. ADTCO3 is a derivative of amantadine used for Parkinson’s disease and has antiviral properties against influenza-A, dengue fever and pharmacological activity towards Parkinson’s disease. The new forms prepared were polymorphic and co-crystal forms of ADTCO3. Polymorphism is a phenomenon where the ability of a substance to exist in two or more crystalline forms occurs when crystallised under different conditions and co-crystallization is the process of formation of multicomponent crystals of a drug substance. New solid forms often display different mechanical, physicochemical and thermal properties that can remarkably influence the bioavailability, hygroscopicity and stability of active pharmaceutical ingredients (APIs). For the formation of polymorphs of ADTCO3, techniques such as dry grinding, solvent-drop grinding, co-precipitation, sublimation and vapour diffusion were applied. For the development of co-crystals and/or complex formation, ADTCO3 was treated in combination with ten selected co-formers viz; benzoic acid, 4-hydroxybenzoic acid, cinnamic acid, 4-hydroxycinnamic acid, succinic acid, tartaric acid, salicylic acid, L-glutamic acid, citric acid monohydrate and L-glutaric acid using similar techniques as applied in the polymorphism study. The first four co-formers were selected for their potential biological activity and the latter six were selected for their generally regarded as safe (GRAS) status. All products were isolated and characterized using different analytical techniques to assess the thermal behaviour of the products by hot stage microscopy (HSM), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). FTIR spectroscopy and proton-nuclear magnetic resonance (1HNMR) were used to identify and determine the purity of the parent compounds and the modified forms. X-ray powder diffraction was used to determine the formation of a new phase and single crystal X-ray diffraction was applied at the initial stages to identify ADTCO3 by its unit cell parameters. Furthermore, the Cambridge Structural Database (CSD) and other resources were used to generate information on the molecular structures of all elucidated parent compounds, their polymorphs and reported co-crystals. Four different polymorphic forms of ADTCO3 were identified (viz. ADTCO3 Forms I to IV) and sixteen co-crystals (viz. ADTCO3BA1 to ADTCO3BA5, ADTCO3HBA, ADTCO3CIN, ADTCO3HCIN, ADTCO3SUC, ADTCO3LTTA, ADTCO3SA, ADTCO3CA, ADTCO3GLA, ADTCO3GA) were synthesised. Of the sixteen co-crystals 5 were identified as ADTCO3BA “salt” co-crystal polymorphic forms and 2 as ADTCO3SUC co-crystal polymorphic forms. Two solvated “salt” co-crystal forms were also identified, namely; ADTCO3GLA and ADTCO3LTTA. ADTCO3GLA had a mass loss of 10.3% (n = 2.4) and ADTCO3LTTA had a mass loss of 5.25% (n = 0.86). Finally, the rest of the co-crystals ADTCO3HBA, ADTCO3CIN, ADTCO3HCIN, ADTCO3SA, ADTCO3CA and ADTCO3GA all crystallised as “salt” co-crystals.
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Omar, Mustafa Saeed. "Crystal growth and characterization of I-IV2-V3 semiconductor compounds and alloys based thereon." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353400.
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The existence of various ternary adamantine compounds is discussed. Normal and defect ternary adamantine compounds have been a subject of discussion, particularly from a structural point of view. Rules for the formation of adamantine compounds are explained and related to each other. A home-made DTA apparatus was operated to detect the melting point and phase change from room temperature up to 1300°C for the materials investigated. The group I-IV2-V3 compounds were the main subject of this research. CuGe2Ps and CuSi2P3 were the only compounds found to grow in this family. The first was chosen for study in more detail, mainly because of its lower melting point. CuGe2P3 was compared to other compounds, particularly structural aspects, and solid solutions were tried for twenty-two different materials. This investigation shows similarity with group I2-IV-V3 compounds, such as Cu2GeS3, and new alloys were found with Cu2GeS3. Stoichiometric Cu2GeS3 does not form good material, but alloys containing 10% CuGe2P3 produced good material with a zincblend structure. As well as alloys with ternary compounds, about 33% Ge per mole could be dissolved in CuGe2P3. This result showed similarity with the compounds Cu2GeSe3 and ZnGeAs2, which also dissolve a considerable quantity of Ge. In this investigation, only a maximum of 33% Si per mole in CuSi2P3 was prepared, although it is likely that even more Si can be dissolved. Attention was also given to AqGe2P3. Chemical analysis of single crystals grown from AgGe2P3 composition showed the existence of only the Ag6Ge10P12 compound. Single crystals were grown for all single phase materials. A new modification of the directional freeze technique was employed, which was capable of controlling the pressure and having a steep temperature gradient. This method improved the growth to produce large single crystals of cm dimensions. The CuGe2P3 crystals doped with Zn, S, Sn, Se and ZnIn were prepared. Single crystals of CuGe2P3 were also annealed with Cu-P and CuGe2P3 powder. Room temperature lattice parameters were determined for all the compounds and alloys, while variations of the lattice parameters with temperatures up to the melting point of CuGe2P3 were studied using a high temperature X-ray camera. Measurements of optical properties were not successful in this investigation, although electrical properties were successfully measured. These measurements were carried out for all materials in a single crystal form. Hall mobility and conductivity measurements were carried out from liquid nitrogen to 450 °K. Carrier concentration was very high for phosphide compounds and alloys, whilst it was lower for sulphides. Flash evaporation was used for preparing thin films of compounds CuGe2P3 and Ag6Ge10P12. Single phase films were the result for Ag6Ge10P12, whilst a particular treatment was employed for producing films of CuGe2P3 after evaporation. A final investigation of the compound CuGe2P3 was made into its lattice matching with other compounds. The p-n junctions were produced with n-type GaP, using epitaxial growth, while results were negative with CdS and Si.
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Valverde, Murillo Elena. "Exploring adamantine-like scaffolds for a wide range of therapeutic targets." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/317952.
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For over eighty years, adamantane ring has interested organic chemists for its simplicity and symmetry. The rigid tricyclo[3.3.1.13,7]decane skeleton has provided a unique structural template for evaluating important theoretical concepts in chemistry.
The physical and chemical properties of the adamantane nucleus have largely overshadowed the structure’s contribution to the discovery of human therapeutics. Nevertheless its application in medicinal chemistry has become more and more significant in the last decades, where the adamantane ring was identified as a key structural subunit in several synthetic drugs for multiple targets. Adamantane is often considered as providing just the critical lipophilicity readily available as an add-on for known pharmacophoric units. Although its valuable contribution to medicinal sciences, adamantane ring can lead to solubility and stability problems which compromise the pharmacokinetic profile of the potential drug. Hence many research teams have worked out alternatives on adamantyl-based compounds in order to avert these issues, especially by attaching polar groups at key positions.
In the last few years, the research group of Dr. Santiago Vázquez from University of Barcelona has developed new polycyclic scaffolds as surrogates of the adamantane group with encouraging results in multiple targets. So far, we have synthesized ring-contracted, ring-expanded and oxa analogues of the drugs amantadine, rimantadine and memantine with anti-influenza, NMDA receptor antagonist and trypanocidal activities, proving the capacity of these polycycles to substitute the adamantane ring.
As described previously, the replacement of the adamantane ring with other polycyclic scaffolds can lead to compounds with better pharmacodynamic and pharmacokinetic profiles. In particular, my Ph.D. research has focused mainly on the substitution of the adamantane moiety in inhibitors of different targets.
1) NMDA receptor antagonists: design, synthesis, pharmacological evaluation and electrophysiological studies of new compounds.
2) 11β-HSD1: design, synthesis, pharmacological evaluation and computational studies of new compounds.
3) Soluble epoxide hydrolase inhibitors: design, synthesis, pharmacological evaluation and in vitro cellular studies of new compounds.
From the results of this dissertation, we have confirmed the ability of the new scaffolds to replace the adamantane nucleus with successful outcomes. The work derived from this thesis have been published in peer scientific journals, as well as in two different patent applications.La recerca duta a terme durant la meva tesi doctoral ha estat centrada principalment en la substitució de l’anell d’adamantà en inhibidors de diferents dianes. Fins al moment, durant la present tesi, he sintetitzat estructures policícliques de diferent mida i forma com anàlegs de l’adamantà per la seva substitució en múltiples dianes farmacològiques. Concretament, he preparat famílies de compostos que tenen com a diana el receptor NMDA del glutamat per la malaltia d’Alzheimer, l’enzim 11β-HSD1 pel tractament de la diabetis mellitus tipus 2 i malalties cardiovasculars, i l’enzim sEH pel tractament del síndrome metabòlic i estats de dolor i inflamació. El nostre objectiu és proporcionar nous compostos amb propietats fisicoquímiques millorades, mentre mantenen la seva potència biològica. Amb la seva avaluació en assajos in vitro, hem demostrat la capacitat d’aquest policicles de substituir l’anell d’adamantà. Cal destacar que la meva recerca ha inclòs el disseny, la síntesi i la caracterització completa dels compostos finals, així com l’avaluació farmacològica i els assajos in vitro d’una de les famílies de compostos.
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Gurierrez, Angélica Souza. "Modelo hidrogeoquímico do Aqüífero Adamantina em Urânia - SP." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/44/44133/tde-12082015-152939/.
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O objetivo desta pesquisa é estabelecer a evolução hidrogeoquímica do Aqüífero Adamantina na cidade de Urânia, noroeste do Estado de São Paulo, definindo as relações químicas entre a água subterrânea e a rocha hospedeira desde a zona de recarga até a descarga. Durante a realização deste trabalho foram coletadas amostras de água em 14 poços cacimbas (PC), 10 poços tubulares particulares (PT) e 7 poços profundos da SABESP (PP), distribuídos na área de estudo, por um período de três anos, para análises físico-químicas de metais, pH, Eh, condutividade elétrica e alcalinidade. Sedimentos da Formação Adamantina de dois poços tubulares também foram amostrados para análise mineralógica (microscopia óptica, difração de raio-X e microscopia eletrônica de varredura), granulométrica (peneiramento e pipetagem) e química (ICP/AES-Plasma). Os resultados obtidos indicaram que a água subterrânea encontra-se em contato com sedimentos arenosos compostos principalmente por quartzo, feldspato (K-feldspato, albita e anortita), anfibólio e piroxênios cálcicos magnesianos, granada, calcita, goetita, hematita, montmorilonita cálcica e caulinita. Quimicamente o sedimento é composto por SiO2 (76% a 78% da massa), seguido pelo ferro e alumínio (4% a 10%), CaO (3,4%) MgO (1,5%), K2O (1%) e Na2O (0,3%). As águas subterrâneas do Aqüífero Adamantina na área de estudo foram divididas em três zonas hidroquímicas dominantes. A zona rasa e de recarga (profundidades de 2,0 a 16,0 m) é caracterizadapor águas cloretadas sódicas devido à presença de contaminação por fossas sépticas e negras, vazamentos da rede de esgoto e/ou fertilizantes nitrogenados. Na zona intermediária (profundidades de 8,0 a 100,0 m) predominam águas bicarbonatada cálcica, causada pela dissolução de minerais carbonáticos e aluminossilicáticos, porém ainda observa-se influência da contaminação. A zona profunda (profundidade de 60,0 a 160,0 m) e de descarga é caracterizada por ) água bicarbonatadas cálcicas, porém foi observada a presença de sódio em poços próximos à zona de descarga, indicando uma possível troca deste cátion com o cálcio.The objective of this study is that of establishing the hydrogeochemical evolution of the Adamantina Aquifer in the city of Urânia, located in the northwest of the state of São Paulo, defining chemical relationships between groundwater and the rock holding this water, from the recharge zone to the discharge zone. During this work, water samples were collected over a period of three years from 14 hand-dug wells (PC), 10 private deep groundwater wells (PT) and 7 SABESP deep groundwater wells (PP), distributed throughout the area under study, with a view to conducting physical-chemical analyses of metals, pH, Eh, electrical conductivity and alkalinity. Adamantina Formation sediments in two of the deep groundwater wells were also sampled for mineralogical analysis (optical microscope, X-ray diffraction and scanning electron microscope), granulometric analysis (sieving and pipeting) and chemical analysis (lCP/AES-Plasma). The results obtained showed that groundwater is to be found in contact with sandy sediments principal|y composed of quartz, feldspar (K-feldspar, albite and anortite), calcium-magnesium amphibole and pyroxenes, garnet, calcite, goethite, hematite, calcium montmorilonite and caulinite. ln chemical terms, this sediment is composed of SiO2 (76% to 78% by mass), followed by iron and aluminum (4% to 10%), CaO (3,4%), MgO (1.5%), K2O (1%) and Na2O (0.3%). The groundwater of the Adamantina Aquifer in the area under study was divided into three predominant hydrochemical zones. The shallow recharge zone (depths ranging from 2.0 to 16.0 cm) is characterized by sodium-chlroride waters, due to the presence of contamination from septic tanks and cesspits, leaks from the sewage collection network and/or nitrogenated fertilizers. ln the intermediate zone (depths ranging from 8.0 to 100.0 m) there is a predominance of calcium-bicarbonate waters, brought about by dissolved carbonate and aluminosilicate minerals, although the influence of contamination can still be seen. The deep discharge zone (depths ranging from 60.0 to 160 m) is characterized by calcium-bicarbonate waters, however, the presence of sodium was detected in wells located close to the discharge zone, indicating the possible exchange of this cation with calcium.
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Braitstein, Lara 1971. "Saraha's Adamantine Songs : texts, contexts, translations and traditions of the Great Seal." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85132.
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My dissertation is focused on a cycle of Saraha's Adamantine Songs and their relationship to the Great Seal. Belonging to a genre known as 'Adamantine Songs'---Vajra Giti in Sanskrit, or rDo rje 'i gLu in Tibetan---their titles are: "A Body Treasury called the Immortal Adamantine Song"; "A Speech Treasury called the Manjughosa Adamantine Song" and "A Mind Treasury called the Unborn Adamantine Song". The dissertation is divided into two parts: the first is the contextualization of a Great Seal (Sanskrit: mahamudra; Tibetan: phyag rgya chenpo) root text by the adept Saraha; and the second is a critical edition of the Tibetan text along with the first full translation of the text into English. The critical edition of the Tibetan is based on versions of the poems drawn from five different Tibetan sources---four scriptural (the sDe dge, Co ne, sNar thang and 'Peking' bsTan 'gyurs) and one literary (Mipham Rinpoche's 19th century collection 'phags yul grub dbang dam pa rnams kyi zab mo'i do ha rnams las kho la byung mu tig phreng ba or "Pearl Garland of the Profound Dohas of the Noble Great Siddhas of India").The first chapters of the dissertation explore the contexts of this song cycle, its author and traditions that relate to it, in particular the Karma Kagyu (karma bka' brgyud) school of Tibetan Buddhism. The first chapter is a discussion of the author, Saraha, the tales of whose many 'lives' pervade Tibetan Buddhist traditions to this day. Chapter 2 explores the broader context of South Asian siddha traditions, while Chapters 3 and 4 provide an analysis of the Great Seal both as it emerges through Saraba's work and as it exists as a living tradition in the Tibetan Buddhist context. As mentioned above, particular emphasis is given to the Karma Kagyu school. Finally, Chapter 5 provides an introduction to Tibetan poetics and the Sanskrit traditions that influence it.
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Santana, Josias Valentim. "Propriedades estruturais, mecânicas, eletrônicas e vibracionais de novas nanoestruturas baseadas em adamantano." reponame:Repositório Institucional da UFC, 2011. http://www.repositorio.ufc.br/handle/riufc/19893.
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SANTANA, J. V. Propriedades estruturais, mecânicas, eletrônicas e vibracionais de novas nanoestruturas baseadas em adamantano. 2011. 219 f. Dissertação (Mestrado em Física) – Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2011.Submitted by Giordana Silva (giordana.nascimento@gmail.com) on 2016-09-30T21:45:33Z No. of bitstreams: 1 2011_dis_jvsantana.pdf: 16163022 bytes, checksum: fd5bbbe526f3a2e3f5edc5833f0b0c9a (MD5)
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This dissertation presents a study of structural, mechanical, electronic and vibrational properties of nanowires, nanoplans and nanotubes based on adamantane. For these structures, geometry optimizations were performed using two different methods: density functional theory in generalized gradient approximation (GGA) with exchange-correlation functional of Perdew, Burke and Ernzerhof (PBE) [1, 2] and the local density approximation (LDA) with exchange-correlation functional of Perdew-Wang (PWC) [1]. From the optimization of these structures, it was possible to calculate properties such as total energy, formation energy, energy gap, band structure and density of states, using the programs Dmol3, Castep and DFTB+. The results show that different symmetries can be obtained for each nanostructure and they preserve the bond lengths of adamantane’s molecule (in the case of nanotubes as we increase the radius). We also observed that the longitudinal Young’s modulus is always larger than the cross. For the thermodynamic stability, we have that the first results show that all structures can exist at room temperature. For the electronic properties, we have that gap from semiconductor to insulating. With respect to the vibrational properties so that each one of them has a particular signature in the IR and Raman spectra, and thus can be differentiated from each other, however, they also carry in your signature characteristic’s peaks corresponding to the adamantane.
Nesta dissertação é apresentado um estudo das propriedades estruturais, mecânicas, eletrônicas e vibracionais de nanofios, nanoplanos e nanotubos baseadas em adamantano. Para essas estruturas foram efetuadas otimizações da geometria usando dois métodos diferentes: Teoria do funcional da densidade na aproximação do gradiente generalizado (GGA) com o funcional de troca e correlação de Perdew, Burke e Ernzerhof (PBE) e a aproximação da densidade local (LDA) com o funcional de troca e correlação de Perdew-Wang (PWC). A partir da otimização dessas estruturas, foi possível calcular propriedades como a energia total, energia de formação, Gap de energia, estrutura de bandas e Densidade de estados, utilizando os programas Dmol3, Castep e DFTB+. Os resultados mostram que diferentes simetrias podem ser obtidas para cada nanoestrutura e que elas preservam os comprimentos de ligação da molécula do adamantano (para o caso dos nanotubos a medida que aumentamos o raio). Observamos também que o módulo de Young longitudinal é sempre maior que o transversal. Quanto à estabilidade termodinâmica, temos que os primeiros resultados mostram que todas as estruturas podem existir a temperatura ambiente. Para as propriedades eletrônicas, temos que são desde semicondutoras de gap largo até isolantes. Com respeito às propriedades vibracionais, temos que cada uma delas apresenta uma assinatura particular no espectro Raman e IR, podendo assim ser diferenciadas umas das outras, contudo, elas também carregam em sua assinatura picos característicos correspondentes ao adamantano.
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Curi, Viviane. "Alterações no periodonto de proteção e ligamento periodontal em molares de ratos ubmetidos ao etanol durante a lactação: estudo Histopatológico e Histométrico." Faculdade de Medicina de São José do Rio Preto, 2010. http://bdtd.famerp.br/handle/tede/94.
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Previous issue date: 2010-11-29Alcoholism is a public health problem worldwide, involving thousands of men and women, bringing serious consequences as a disease in all organs of the human body, especially the stomach, liver, heart and brain. The consumption of alcoholic beverages for infants and mothers have attracted the attention of researchers in recent decades, with significant. Objective: This study aimed to evaluate the effects of ethanol in the junctional epithelium, adamantine epithelium, epithelium of attached gingiva and periodontal ligament of the upper first molar of the rat, during lactation. Materials and Methods: To this end, we used mice with a day of postnatal life, whose mothers received 20% ethanol in drinking water and rats whose mothers do not received ethanol during the entire lactation. After 21 days, the chicks were sacrificed with anesthetic overdose (Hypnol 3%). The heads were separated and fixed in a solution of "alfac" (alcohol 80% -85 ml, 10 ml of formalin and acetic acid 5-ml), embedded in paraffin and frontal serial sections were stained with hematoxylin and eosin. The cuts were focused light microscope (100x) fitted with a camera lucida. The nuclei of cells from tissue fragments were designed on paper with increased end of 1000x. and 50 nuclei of each structure were outlined with black pencil for later measurement of larger (D) and smaller (d)diameters. Once determined the diameters were estimated karyometric following parameters: geometric mean diameter ratio D / d, perimeter, area, volume, relationship between volume and area, eccentricity, shape coefficient and contour índex. This work also was done using a grid printed on paper. The images were drawn on the grid. In order to assess the volumes and cell cytoplasm, the nucleus / xxiv cytoplasm ratio, the numerical cell density, relation to the external surface / basal layer, the thickness of epithelial layers and the density of the surface was sometimes used the count of the points and sometimes the number of intersections and applied to stereological equations appropriate for each of these variables. All data collected were submitted to non-parametric statistics (Wilcoxon-Mann-Whitney). Results: Histologically, the superior maxillar molar tooth of the rat treated with ethanol was not erupted or partially eruído; the junctional epithelium was reduced and the adamant epithelium was in full function and consists of high palisade cells. The epithelium of attached gingiva was more slender and composed of smaller cells. In the Periodontal ligament was possible to observe bigger and disorganizedfibers. The nuclei of the epithelia studies have shown decreased values after Karyometry, for larger and smaller medium diameters, volume, area, perimeter, and the relation V / A. Stereologically could be observed in the junctional epithelium, adamantine and the attached gingiva, less voluminous cell with scarce cytoplasm leading to a greater number of cells per mm3 of tissue. The disorganized periodontal ligament showed larger fibers with smaller number per mm3. Conclusion: In this study, ethanol resulted in a framework of epithelial hypotrophy, indicating a direct action on the junctional and adamantineepithelium, epithelium of attached gingiva and periodontal ligament.
O alcoolismo é um problema de saúde pública mundial, envolvendo milhares de homens e mulheres, trazendo conseqüências graves como doença em todos os órgãos do corpo do humano, em especial o estômago, o fígado, o coração e o cérebro. O consumo de bebidas alcoólicas por lactantes e lactentes vem despertando a atenção dos pesquisadores, nas últimas décadas, com achados significantes. Objetivo: Este trabalho teve como objetivo avaliar os efeitos do etanol no epitélio juncional, epitélio adamantino, epitélio da gengiva inserida e ligamento periodontal do primeiro molar superior do rato, durante a lactação. Materiais e Métodos: Para tal, foram utilizados ratos com um dia de vida pós-natal, cujas mães receberam etanol a 20% na água do bebedouro e ratos cujas mães não receberam o etanol, durante toda a lactação. Ao final de 21 dias, os filhotes foram sacrificados com sobredosagem anestésica (Hypnol a 3%). As cabeças foram separadas e fixadas em solução de alfac (álcool 80%-85 ml, formalina-10 ml e ácido acético-5 ml), incluídas em parafina e os cortes frontais seriados foram corados com hematoxilina e eosina. Os cortes foram focalizados ao microscópio de luz (100x) munido de uma câmara clara. Os núcleos das células dos tecidos estudados foram projetados sobre papel com aumento final de 1000x. e 50 núcleos de cada estrutura foram contornados com lápis preto para posterior medição dos diâmetros maior (D) e menor (d). Uma vez determinados os diâmetros, foram estimados os seguintes parâmetros cariométricos: diâmetro geométrico médio, relação entre D/d, perímetro, área, volume, relação entre volume e área, xxi excentricidade, coeficiente de forma e índice de contorno. Neste trabalho também, foi utilizada uma grade impressa sobre papel. As imagens obtidas foram desenhadas sobre a grade. Com a finalidade de se avaliar os volumes citoplasmáticos e celular, a relação núcleo/citoplasma, a densidade numérica celular, a relação superfície externa/ camada basal, a espessura das camadas epiteliais e a densidade da superfície, foi utilizada ora a contagem de pontos ora o número de intersecções e aplicadas às equações estereológicas apropriadas para cada uma dessas variáveis. Todos os dados colhidos foram submetidos à estatística não-paramétrica (teste de Wilcoxon-Mann-Whitney). Resultados: Histologicamente, o dente molar do maxilar superior do rato tratado com etanol não estava erupcionado ou então, parcialmente erupcionado; o epitélio juncional estava reduzido e o epitélio adamantino presente estava em plena função e constituído de células altas em paliçada. O epitélio da gengiva inserida era mais delgado e constituído de células menores. No ligamento periodontal foi possível observar fibras desorganizadas e maiores. Os núcleos dos epitélios estudados mostraram valores diminuídos, após cariometria, para os diâmetros maior, menor e médio; volume, área, perímetro e relação V/A. Estereologicamente foi possível observar, nos epitélios juncional, adamantino e da gengiva inserida, células menos volumosas com citoplasma mais escasso levando a um maior número de células por mm3 de tecido. O ligamento periodontal desorganizado mostrou fibras mais volumosas e com menor número por mm3. Conclusões: Neste estudo, o etanol ocasionou um quadro de hipotrofia epitelial, indicando uma xxii ação direta nos epitélios juncional e adamantino, epitélio de gengiva inserida bem como no ligamento periodontal.
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Lauenstein, Oliver. "Selektive Halogenierungen unter Phasentransferbedingungen mechanistische Untersuchungen und synthetische Anwendungen /." Doctoral thesis, [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963021443.
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Foulon, Michel. "Les Phases cristallines des adamantanes 1 substitués (plastiques, ordonnées, vitreuses) thermodynamique, structures, mouvements moléculaires /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376051794.
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Claes, Dorith [Verfasser], and Wolfgang [Akademischer Betreuer] Maison. "Boronolektine auf Basis von Adamantan zur Erkennung von Kohlenhydraten / Dorith Claes. Betreuer: Wolfgang Maison." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1045730432/34.
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Fleck, Carsten [Verfasser], and Wolfgang [Akademischer Betreuer] Maison. "Synthese und Evaluierung von Glycokonjugaten auf Basis von Adamantan / Carsten Fleck. Betreuer: Wolfgang Maison." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1071948261/34.
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Claes, Dorith Verfasser], and Wolfgang [Akademischer Betreuer] [Maison. "Boronolektine auf Basis von Adamantan zur Erkennung von Kohlenhydraten / Dorith Claes. Betreuer: Wolfgang Maison." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://nbn-resolving.de/urn:nbn:de:gbv:18-65225.
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Le, ho Khanh hy. "Synthèse par « Click Chemistry » de matériaux hybrides et éudes de leurs assemblages supramoléculaires." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112285/document.
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L’approche « bottum-up » via l’auto-assemblage moléculaire est considéré comme une voie prometteuse pour contrôler la fabrication de nouveaux matériaux et leur intégration dans des dispositifs hybrides présentant de propriétés nouvelles. Dans ce travail, nous avons synthétisé plusieurs hybrides à base de molécules organiques (fullerène, porphyrines, phtalocyanine), d’oligonucléotides ou de nanotubes de carbone.Dans un premier temps, nous nous sommes intéressés à la synthèse d’une nouvelle famille de produits constituée d’une unité C60 lié à deux chromophores positionnés face à face et permettant la formation de complexes hôte-invités. Nous avons montré que ces composés s’assemblent pour donner des structures supramoléculaires en solution et sur surface. Les interactions électroniques et la compléxation entre le fullerène et les deux chromophores (porphyrines et phtalocyanines) ont été étudiées par spectroscopie optique et RMN ainsi que par voltammétrie cyclique.Parmi les outils de l’approche « bottom-up », l’ADN a montré son extraordinaire potentiel pour la fabrication d’assemblages bio-dirigés. En effet, la synthèse de matériaux hybrides à base d’ADN permet un contrôle précis (théoriquement à l’échelle d’une base, ~3,4Å) du positionnement des groupements fonctionnels dans un matériau. Dans le but de former des réseaux bi- et tridimensionnels à base d’ADN permettant le positionnement de nano-objets, nous avons synthétisé des hybrides à base d’oligonucléotides et de porphyrines (molécule 2D) ou d’adamantane (molécule 3D). Des édifices supramoléculaires simples ont été réalisés et le travail se poursuit en vue de la réalisation de réseaux fonctionnels.Enfin, dans une dernière partie, nous nous sommes intéressés à la fonctionnalisation des nanotubes de carbone monoparoi (SWNT) avec des chromophores de type porphyrines et phtalocyanines. Alors que les porphyrines présentent une absorption intense presque exclusivement dans le bleu, les phtalocyanines absorbent principalement dans le rouge. Combiner ces deux chromophores à la surface des nanotubes de carbone présente donc un intérêt particulier pour la collecte de lumière car les deux composés absorbent des régions complémentaires du spectre visible. Ce travail ouvre la voie vers l'étude des propriétés optoélectroniques des hybrides à base de nanotubes et en particulier leur utilisation pour la conversion d’énergie lumineuse en énergie électrique (application photovoltaïque)An Approach "bottum-up" via molecular self-assembly is considered as a promising way to control the manufacture of new materials and their integration into hybrid devices with novel properties. In this work, we have synthesized several hybrids based on organic molecules (fullerene, porphyrin, phthalocyanine), oligonucleotides or carbon nanotubes.At first, we were interested in the synthesis of a new family of products consisting of a unit C60 linked to two chromophores positioned face to face and allowing the formation of host-guest complexes. We have shown that these compounds are combined to give supramolecular structures in solution and on the surface. Electronic interactions and complexation between fullerene and the two chromophores (porphyrins and phthalocyanines) were studied by NMR and optical spectroscopy as well as cyclic voltammetry.Among the tools of the "bottom-up", DNA showed its tremendous potential for the production of bio-directed assembly. Indeed, the synthesis of hybrid materials based DNA allows precise control (theoretically on the scale of a base, ~ 3.4 Å) of the positioning of the functional groups in a material. In order to form networks and bi-dimensional DNA-based for positioning nano-objects, we have synthesized hybrid oligonucleotide-based and porphyrin molecule (2D) or adamantane molecule (3D). Supramolecular structures have been made and this work is ongoing to achieve functional networks.Finally, in a last part, we are interested in the functionalization of single-walled carbon nanotubes (SWNTs) with chromophores like porphyrins and phthalocyanines. While porphyrins exhibit almost exclusively an intense absorption in the blue (around 420-440 nm), phtalocyanines absorb mainly in the red spectral region. Taken together these two chromophores have interesting light harvesting, photophysical and redox properties; the two components will participate independently to increase the overall absorption in the visible range of the solar spectrum. This work opens the route to study the optoelectronic properties of hybrid nanotube and in particular their use for the conversion of light energy into electrical energy (photovoltaic application)
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Beji, Mohamed. "Heterocumulenes alpha -sulfonyles et leurs applications a la synthese de nouvelles structures heterocycliques : alkylation des esters sulfamiques en catalyse par transfert de phase." Paris 7, 1987. http://www.theses.fr/1987PA077183.
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