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Bahri-Sahloul, Radhia, Radhia Ben Fredj, Naima Boughalleb, Jihène Shriaa, Saâd Saguem, Jean-Louis Hilbert, Francis Trotin, Saida Ammar, Sadok Bouzid, and Fethia Harzallah-Skhiri. "Phenolic Composition and Antioxidant and Antimicrobial Activities of Extracts Obtained from Crataegus azarolus L. var. aronia (Willd.) Batt. Ovaries Calli." Journal of Botany 2014 (January 20, 2014): 1–11. http://dx.doi.org/10.1155/2014/623651.
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Objective. Plant cell culture is an innovative technology to produce a variety of substances. Numerous plants synthesize among their secondary metabolites phenolic compounds which possess antioxidant and antimicrobial effects. Hawthorn (Crataegus) is one of these plants which has long been used in folk medicine and is widely utilized in pharmaceutical preparations mainly in neuro- and cardiosedative actions. Methods and Results. The production of polyphenol by fifty-two-week-old Crataegus azarolus var. aronia calli was studied in relation to growth variation and antioxidant and antimicrobial capacity within a subcultured period. The DPPH and ABTS+ assays were used to characterize the antioxidant actions of the callus cultures. Antimicrobial activity was tested by using disc diffusion and dilution assays for the determination of the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) values of each active extract. High TEACDPPH, TEACABTS, and antimicrobial activity was observed when maximal growth was reached. An optimum of total phenol, proanthocyanidins, flavonoid, (−)-epicatechin, procyanidin B2, chlorogenic acid, and hyperoside was produced during this period. Conclusion. Antioxidant and antimicrobial activities were strongly correlated with total phenols and total flavonoids. Crataegus azarolus var. aronia cells culture represents an important alternative source of natural antioxidants and antimicrobials.
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Loginova, Natalia V., Hleb I. Harbatsevich, Nikolai P. Osipovich, Galina A. Ksendzova, Tatsiana V. Koval’chuk, and Genrikh I. Polozov. "Metal Complexes as Promising Agents for Biomedical Applications." Current Medicinal Chemistry 27, no. 31 (September 11, 2020): 5213–49. http://dx.doi.org/10.2174/0929867326666190417143533.
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Background:: In this review article, a brief overview of novel metallotherapeutic agents (with an emphasis on the complexes of essential biometals) promising for medical application is presented. We have also focused on the recent work carried out by our research team, specifically the development of redox-active antimicrobial complexes of sterically hindered diphenols with some essential biometals (copper, zinc, nickel). Results:: The complexes of essential metals (manganese, iron, cobalt, nickel, copper, zinc) described in the review show diverse in vitro biological activities, ranging from antimicrobial and antiinflammatory to antiproliferative and enzyme inhibitory. It is necessary to emphasize that the type of organic ligands in these metal complexes seems to be responsible for their pharmacological activities. In the last decades, there has been a significant interest in synthesis and biological evaluation of metal complexes with redox-active ligands. A substantial step in the development of these redox-active agents is the study of their physicochemical and biological properties, including investigations in vitro of model enzyme systems, which can provide evidence on a plausible mechanism underlying the pharmacological activity. When considering the peculiarities of the pharmacological activity of the sterically hindered diphenol derivatives and their nickel(II), copper(II) and zinc(II) complexes synthesized, we took into account the following: (i) all these compounds are potential antioxidants and (ii) their antimicrobial activity possibly results from their ability to affect the electron-transport chain. Conclusion:: We obtained novel data demonstrating that the level of antibacterial and antifungal activity in the series of the above-mentioned metal-based antimicrobials depends not only on the nature of the phenolic ligands and complexing metal ions, but also on the lipophilicity and reducing ability of the ligands and metal complexes, specifically regarding the potential biotargets of their antimicrobial action – ferricytochrome c and the superoxide anion radical. The combination of antibacterial, antifungal and antioxidant activity allows one to consider these compounds as promising substances for developing therapeutic agents with a broad spectrum of activities.
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Leitgeb, Maja, Kaja Kupnik, Željko Knez, and Mateja Primožič. "Enzymatic and Antimicrobial Activity of Biologically Active Samples from Aloe arborescens and Aloe barbadensis." Biology 10, no. 8 (August 11, 2021): 765. http://dx.doi.org/10.3390/biology10080765.
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Recently, the use of Aloe species has become very widespread. These are extensively used as a nutraceutical in a variety of health care products and food supplements. In addition, the occurrence of the quickly adaptable microorganisms, particularly bacteria, which can develop resistance to antibiotics, is a major problem for public health, and therefore, it is necessary to search for new antimicrobials. In our study, the content of total phenols, proanthocyanidins, and proteins in fresh and lyophilized samples of A. arborescens and A. barbadensis and their ethanol extracts was investigated. Furthermore, enzymatic and antioxidant activity of samples were studied. Since antimicrobial activity of fresh samples was determined in our latest research, a more detailed study of antimicrobial effectiveness of A. arborescens and A. barbadensis (lyophilized, extracts) was performed. Ethanol extracts in particular contain higher concentrations of bioactive substances and show the topmost antioxidant activity. The novelty of the study refers to the observation of industrially important enzyme activities such as α-amylase, cellulase, lipase, peroxidase, protease, and transglutaminase in the samples as well as the microbial growth inhibition rates determination (MGIR) at different concentrations of added aloe samples. All samples inhibited the growth of all tested microbial cells. MIC90 for A. arborescens and A. barbadensis were also determined in case of B. cereus, P. aeruginosa, P. fluorescens, and S. aureus. The results of our study tend to give credence to the popular use of both aloes in medicine and in the cosmetic, food, and pharmaceutical industries.
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Wolski, Grzegorz J., Beata Sadowska, Marek Fol, Anna Podsędek, Dominika Kajszczak, and Agnieszka Kobylińska. "Cytotoxicity, antimicrobial and antioxidant activities of mosses obtained from open habitats." PLOS ONE 16, no. 9 (September 20, 2021): e0257479. http://dx.doi.org/10.1371/journal.pone.0257479.
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Mosses are mainly the object of ecological and taxonomic research. This group of plants are still underestimated by scientists in other aspects of research. Recent research has shown that these plants contain remarkable and unique substances with high biological activity. Five species of mosses from a large urban ecosystem were identified for present study. In order to determine their biological potential, multifaceted studies were carried out, including: total phenolics content, antioxidant activity, antimicrobial and antifungal study, cytotoxicity evaluation, and scratch assay to assess pro-regenerative effect in the context of their possible use as the ingredients of biologically active cosmetics. Additionally, determination of individual phenolic compounds in selected extracts of the tested mosses was made. Research showed that Ceratodon purpureus and Dryptodon pulvinatus extracts had the greatest potential as antioxidants and antimicrobial activity. The cytotoxicity assessment indicated that the extracts from Dryptodon pulvinatus and Rhytidiadelphus squarossus exerted the strongest negative effect on mouse fibroblast line L929 viability at higher concentrations. While, the extract from Tortulla muralis best stimulated human foreskin fibroblast line HFF-1 proliferation and wound healing. The research on individual phenolic compounds content in the extracts tested indicated over 20 peaks on UPLC chromatograms. The conducted study has shown that mosses, especially so far unexplored species of open ecosystems, and e.g. epilytic habitats, may be a valuable source of biologically active substances and thus may constitute important medical and cosmetic possibilities.
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González-Reza, Ricardo, Claudia García-Betanzos, Liliana Sánchez-Valdes, David Quintanar-Guerrero, María Cornejo-Villegas, and María Zambrano-Zaragoza. "The Functionalization of Nanostructures and Their Potential Applications in Edible Coatings." Coatings 8, no. 5 (April 26, 2018): 160. http://dx.doi.org/10.3390/coatings8050160.
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Nowadays, edible coatings incorporated with nanostructures as systems of controlled release of flavors, colorants and/or antioxidants and antimicrobial substances, also used for thermal and environmental protection of active compounds, represent a gap of opportunity to increase the shelf life of food highly perishable, as well as for the development of new products. These functionalized nanostructures have the benefit of incorporating natural substances obtained from the food industry that are rich in polyphenols, dietary fibers, and antimicrobial substances. In addition, the polymers employed on its preparation, such as polysaccharides, solid lipids and proteins that are low cost and developed through sustainable processes, are friendly to the environment. The objective of this review is to present the materials commonly used in the preparation of nanostructures, the main ingredients with which they can be functionalized and used in the preparation of edible coatings, as well as the advances that these structures have represented when used as controlled release systems, increasing the shelf life and promoting the development of new products that meet the characteristics of functionality for fresh foods ready to eat.
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Rakhimov, K. D., Zh B. Abuova, and A. A. Turgumbaeva. "PROSPECTS FOR THE USE OF SAFFLOWER (CARTHAMUS TINCTORIUS L) IN OPHTHALMOLOGY." REPORTS 2, no. 330 (April 15, 2020): 29–35. http://dx.doi.org/10.32014/10.32014/2020.2518-1483.28.
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Plant materials and preparations based on it continue to play an important role in the pharmacotherapy of many chronic and sluggish human diseases. Over the past two decades, there has been a very high consumer demand for medicines and preventive products obtained from natural plant sources. This is due to the complex effect of biologically active substances, vitamins, antioxidants of plant origin on the human body and the practical absence of side effects. An analysis of the development of phytopharmacology shows that the most promising direction in the field of the development of phytopreparations is the scientifically based use of the experience of traditional and modern medicine. One of the promising types of raw material - medicinal plant safflower (Carthamus tinctorius L). It contains vitamins A, E, unsaturated fatty acids and other biologically active substances in large quantities, that determine antimicrobial, antifungal, anti-inflammatory, antioxidant properties. Thanks to these pharmacological effects, the content of vitamins is promising for the development and introduction of a drug used in the field of ophthalmology. To this end we have searched and analysed scientific publications about safflower – Carthamus tinctorius. All studies used in this review have been found using «Google Scholar» scientific search engine and were selected from publications indexed in Web of science, PubMed, Medline, E–library, and Cyberleninka databases.
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Salishcheva, Olesya, and Alexander Prosekov. "Antimicrobial activity of mono- and polynuclear platinum and palladium complexes." Foods and Raw Materials 8, no. 2 (September 30, 2020): 298–311. http://dx.doi.org/10.21603/2308-4057-2020-2-298-311.
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Introduction. Infectious diseases remain a serious threat to humanity worldwide as bacterial pathogens grow more diverse. Bacteria, fungi, and parasites develop resistance to clinically approved antimicrobials, which reduces the efficacy of available drugs and treatment measures. As a result, there is an ever growing demand for new highly effective pharmaceuticals. This review describes mono- and polynuclear platinum and palladium complexes with antimicrobial properties. We compared several groups of antibacterial agents: antibiotics, antioxidant biologically active substances, antimicrobial nanoparticles, nanocomposite materials, biopolymers, micellar systems, and plant extracts.
Study objects and methods. The review covered relevant articles published in Web of Science, Scopus, and Russian Science Citation Index for the last decade. The list of descriptors included such terms as mononuclear and binuclear complexes of platinum, palladium, and antimicrobial activity.
Results and discussion. Chelates of platinum, palladium, silver, iridium, rhodium, ruthenium, cobalt, and nickel are popular therapeutic agents. Their antimicrobial activity against pathogenic microorganisms can be enhanced by increasing their bioavailability. Metalbased drugs facilitate the transport of organic ligands towards the bacterial cell. The nature of the ligand and its coordination change the thermodynamic stability, kinetic lability, and lipophilic properties of the complex, as well as the reactivity of the central atom. Polynuclear platinum and palladium complexes contain two or more bound metal (coordinate) centers. Covalent bonding with bacterial DNA enables them to form a type of DNA adducts, which is completely different from that of mononuclear complexes.
Conclusion. Metal-based drugs with functional monodentate ligands exhibit a greater antimicrobial effect compared to free ligands. Poly- and heteronuclear complexes can increase the number of active centers that block the action of bacterial cells. When combined with other antibacterial agents, they provide a synergistic effect, which makes them a promising subject of further research.
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Pateiro, Mirian, Belén Gómez, Paulo E. S. Munekata, Francisco J. Barba, Predrag Putnik, Danijela Bursać Kovačević, and José M. Lorenzo. "Nanoencapsulation of Promising Bioactive Compounds to Improve Their Absorption, Stability, Functionality and the Appearance of the Final Food Products." Molecules 26, no. 6 (March 11, 2021): 1547. http://dx.doi.org/10.3390/molecules26061547.
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The design of functional foods has grown recently as an answer to rising consumers’ concerns and demands for natural, nutritional and healthy food products. Nanoencapsulation is a technique based on enclosing a bioactive compound (BAC) in liquid, solid or gaseous states within a matrix or inert material for preserving the coated substance (food or flavor molecules/ingredients). Nanoencapsulation can improve stability of BACs, improving the regulation of their release at physiologically active sites. Regarding materials for food and nutraceutical applications, the most used are carbohydrate-, protein- or lipid-based alternatives such as chitosan, peptide–chitosan and β-lactoglobulin nanoparticles (NPs) or emulsion biopolymer complexes. On the other hand, the main BACs used in foods for health promoting, including antioxidants, antimicrobials, vitamins, probiotics and prebiotics and others (minerals, enzymes and flavoring compounds). Nanotechnology can also play notable role in the development of programmable food, an original futuristic concept promising the consumers to obtain high quality food of desired nutritive and sensory characteristics.
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Restrepo, Andrea E., José D. Rojas, Omar R. García, Leidy T. Sánchez, Magda I. Pinzón, and Cristian C. Villa. "Mechanical, barrier, and color properties of banana starch edible films incorporated with nanoemulsions of lemongrass (Cymbopogon citratus) and rosemary (Rosmarinus officinalis) essential oils." Food Science and Technology International 24, no. 8 (July 31, 2018): 705–12. http://dx.doi.org/10.1177/1082013218792133.
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Edible films are among the most promising fields in food science over the last decade due to their versatility (they can be made from a wide array of materials) and because they can be used as carriers of different active substances, like antioxidants, antimicrobial agents, and essential oils from plants. In the case of the essential oils, their inclusion in edible films is limited by their low water solubility. Nanoemulsions are thermodynamically stable and transparent systems that can be used as a way of incorporating essential oils into edible film matrices. In this paper, we developed lemongrass and rosemary essential oil nanoemulsions by using a low-energy method, observing the effect of the surfactant/oil ratio in their physicochemical properties. Then we studied the effect of the nanoemulsions concentration incorporated into banana starch edible films. We observed that essential oils’ nanoemulsions have a plasticizing effect increasing the film’s water vapor permeability, transparency, and elongation at break, while the hydrophobic nature of the essential oils lead to a decrease in their water solubility.
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Lumbiny, Bilkis Jahan, Zhang Hui, and M. Azizul Islam. "Antiaging, antioxidant flavonoids; synthesis, antimicrobial screening as well as 3D QSAR CoMFA models for the prediction of biological activity." Journal of the Asiatic Society of Bangladesh, Science 39, no. 2 (February 3, 2014): 191–99. http://dx.doi.org/10.3329/jasbs.v39i2.17856.
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Flavonoids, polyphenolic heteronuclear compounds which are naturally occurring antioxidants are widely used as antiaging substances. Synthesis of new naturally occuring organic compounds with basic skeleton of chalcones, flavones and oxygenated flavones and their antimicrobial activity were reported by this research group for long. Presently comparative molecular field analysis (CoMFA) implemented in Sybyl 7.3 was conducted on a series of substituted flavones. CoMFA is an effective computer implemented 3D QSAR technique deriving a correlation between set of the biologically active molecules and their 3D shape, electrostatic and hydrogen bonding characteristics employing both interactive graphics and statistical techniques. Evaluation of 38 compounds were served to establish the models with grid spacing (2.0 Å). CoMFA produced best predictive model for compound 1C (2 ? Phenyl ? 1,4 ? benzopyrone) and compound 2C (5 ? Fluoro ? 3?? hydroxy flavone ) among all. Model for compound 2C [r2 conv (no-validation) = 0.956, SEE = 0.211, F value = 111.054) is better than that of compound 1C [r2 conv (no-validation) = 0.955, SEE = 0.212, F value = 110.261) but comparing superimposed model 1C being suggested as the best predictive model. 3D contour maps were generated to correlate the biological activities with the chemical structures of the examined compounds and for further design. DOI: http://dx.doi.org/10.3329/jasbs.v39i2.17856 J. Asiat. Soc. Bangladesh, Sci. 39(2): 191-199, December 2013
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Asyakina, Lyudmila, Svetlana Ivanova, Alexander Prosekov, Lyubov Dyshlyuk, Evgeny Chupakhin, Elena Ulrikh, Olga Babich, and Stanislav Sukhikh. "Determination of the Qualitative Composition of Biologically Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhaponticum carthamoides." Applied Sciences 11, no. 6 (March 12, 2021): 2555. http://dx.doi.org/10.3390/app11062555.
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This work aims to study the qualitative composition of biologically active substance (BAS) extracts in vitro callus, cell suspension, and root cultures of the medicinal plant Rhaponticum carthamoides. The research methodology is based on high-performance liquid chromatography, and 1H nuclear magnetic resonance (NMR) spectra, to study the qualitative and quantitative analysis of BAS. The results of the qualitative composition analysis of the dried biomass extracts of in vitro callus, cell suspension and root cultures showed that the main biologically active substances in the medicinal plant Rhaponticum carthamoides are 2-deoxy-5,20,26-trihydroxyecdyson (7 mg, yield 0.12%), 5,20,26-trihydroxyecdyson 20,22-acetonide (15 mg, yield 0.25%), 2-deoxy-5,20,26-trihydroxyecdyson 20,22-acetonide (6 mg, yield 0.10%), 20,26-dihydroxyecdyson 20,22-acetonidecdyson 20,22-acetonide (5 mg, yield 0.09%), and ecdyson 20,22-acetonide (6 mg, yield 0.10%). In the future, it is planned to study the antimicrobial, antioxidant, and antitumor activity of BAS of extracts of in vitro callus, cell suspension, and root cultures of the medicinal plant Rhaponticum carthamoides, for the production of pharmaceuticals and dietary supplements with antitumor, antimicrobial and antioxidant effects.
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Hou, Huiwen, Juan Wang, Jie Wang, Wen Tang, Abdul Sami Shaikh, Yan Li, Jiaai Fu, et al. "A Review of Bioactive Peptides: Chemical Modification, Structural Characterization and Therapeutic Applications." Journal of Biomedical Nanotechnology 16, no. 12 (December 1, 2020): 1687–718. http://dx.doi.org/10.1166/jbn.2020.3001.
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In recent years, the development and applications of protein drugs have attracted extensive attention from researchers. However, the shortcomings of protein drugs also limit their further development. Therefore, bioactive peptides isolated or simulated from protein polymers have broad application prospects in food, medicine, biotechnology, and other industries. Such peptides have a molecular weight distribution between 180 and 1000 Da. As a small molecule substance, bioactive peptide is usually degraded by various enzymes in the organism and have a short half-life. At the same time, such substances have poor stability and are difficult to produce and store. Therefore, these active peptides may be modified through phosphorylation, glycosylation, and acylation. Compared with other protein drugs, the modified active peptides are more easily absorbed by the body, have longer half-life, stronger targeting, and fewer side effects in addition to higher bioavailability. In the light of their functions, bioactive peptide can be divided into antimicrobial, anti-tumour, anti-angiogenic, antioxidant, anti-fatigue, and anti-hypertensive peptides. This article mainly focuses on the introduction of several promising biologically active peptides functioning as antimicrobial, anti-tumour, antiangiogenic, and antioxidant peptides from the three aspects modification, structural characteristics and mechanism of action.
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Fatrcová-Šramková, Katarína, Janka Nôžková, Magda Máriássyová, and Miroslava Kačániová. "Biologically active antimicrobial and antioxidant substances in theHelianthus annuusL. bee pollen." Journal of Environmental Science and Health, Part B 51, no. 3 (December 16, 2015): 176–81. http://dx.doi.org/10.1080/03601234.2015.1108811.
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Figueroa-Lopez, Kelly J., António A. Vicente, Maria A. M. Reis, Sergio Torres-Giner, and Jose M. Lagaron. "Antimicrobial and Antioxidant Performance of Various Essential Oils and Natural Extracts and Their Incorporation into Biowaste Derived Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Layers Made from Electrospun Ultrathin Fibers." Nanomaterials 9, no. 2 (January 23, 2019): 144. http://dx.doi.org/10.3390/nano9020144.
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In this research, the antibacterial and antioxidant properties of oregano essential oil (OEO), rosemary extract (RE), and green tea extract (GTE) were evaluated. These active substances were encapsulated into ultrathin fibers of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from fruit waste using solution electrospinning, and the resultant electrospun mats were annealed to produce continuous films. The incorporation of the active substances resulted in PHBV films with a relatively high contact transparency, but it also induced a slightly yellow appearance and increased the films opacity. Whereas OEO significantly reduced the onset of thermal degradation of PHBV, both the RE and GTE-containing PHBV films showed a thermal stability profile that was similar to the neat PHBV film. In any case, all the active PHBV films were stable up to approximately 200 °C. The incorporation of the active substances also resulted in a significant decrease in hydrophobicity. The antimicrobial and antioxidant activity of the films were finally evaluated in both open and closed systems for up to 15 days in order to anticipate the real packaging conditions. The results showed that the electrospun OEO-containing PHBV films presented the highest antimicrobial activity against two strains of food-borne bacteria, as well as the most significant antioxidant performance, ascribed to the films high content in carvacrol and thymol. Therefore, the PHBV films developed in this study presented high antimicrobial and antioxidant properties, and they can be applied as active layers to prolong the shelf life of the foods in biopackaging applications.
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Sukhikh, Stanislav, Svetlana Noskova, Svetlana Ivanova, Liubov Skrypnik, Artem Pungin, Elena Ulrikh, Evgeny Chupakhin, and Olga Babich. "Study of the Properties of In Vitro Dactylorhiza maculata (L.) Soó (Family Orchidaceae) Extracts." Plants 10, no. 7 (June 29, 2021): 1330. http://dx.doi.org/10.3390/plants10071330.
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The medicinal plant Dactylorhiza maculata (L.) Soó (family Orchidaceae) is used to treat gastritis, colic, gastrointestinal tract, and bladder diseases. This study aimed to investigate the properties and characteristics of the in vitro Dactylorhiza maculata extract. The recommended parameters for producing Dactylorhiza maculata extract were determined: temperature 60 °C, process duration 60 min, hydro module 1:10. It is recommended to carry out the extraction using an aqueous ethyl alcohol solution with a mass fraction of the parent substance of 70%. It was found that such biologically active substances as rutin, quercetin, 3,3′,4′,5,5′,7-hexahydroxyflavonone, 3,3′,4′,5,5′,7-hexahydroxyflavonone-3-O-glycoside, gallic acid, and ferulic acid were dominant in Dactylorhiza maculata. A high phosphorus content was noted (2410.8 mg/kg dry matter). The studied Dactylorhizamaculata samples contained a large number of organic acids and water-soluble vitamins. The tested extracts were safe in terms of the content of heavy metals, pesticides, aflatoxin B1, and radionuclides, as well as pathogenic and opportunistic microorganisms; the content was significantly lower than the threshold limit values. The studied complex of biologically active substances from Dactylorhiza maculata extract samples had antimicrobial properties. It was found that the antioxidant activity of the samples was 217.89 ± 10.89 mg AA/g (AA—ascorbic acid). The high content of bioactive substances and the antimicrobial and antioxidant properties of Dactylorhizamaculata extract samples determine the application potential of this plant as a substitute for growth stimulants and feed antibiotics in the production of feed additives, aiming to increase the physiological and immune status of livestock and poultry.
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Volmajer Valh, Julija, Zdenka Peršin, Bojana Vončina, Kaja Vrezner, Lidija Tušek, and Lidija Fras Zemljič. "Microencapsulation of Cannabidiol in Liposomes as Coating for Cellulose for Potential Advanced Sanitary Material." Coatings 11, no. 1 (December 22, 2020): 3. http://dx.doi.org/10.3390/coatings11010003.
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The microencapsulation of the cannabidiol and its integration into the tampon can eliminate vaginal inflammation, which at the same time lead to relaxation of the abdominal muscles. The tampon, which contains the active substance cannabidiol (CBD), was developed as an advanced fibrous composite for sanitary application. The active substances were microencapsulated, and, as a carrier, liposomes micro/nano capsules were used. The CBD liposome formulation was analyzed by particle size, polydispersity index, zeta potential, and encapsulation efficiency. Particle size of the CBD liposome liquid formulation was increased by 19%, compared to the liposome liquid formulation and the encapsulation efficiency of CBD in liposome particles, which was 90%. The CBD liposome formulation was applied to cellulose material. The composition of the fibrous composite material was evaluated by Fourier transform infrared spectroscopy, the fiber morphology was analyzed by scanning electron spectroscopy, while the bioactive properties were assessed by antioxidant efficiency, antimicrobial properties, and desorption kinetics. CBD liposome functionalized tampons have both antioxidant and antimicrobial properties. Antimicrobial properties were more pronounced against Gram-positive bacteria. The desorption kinetics of the CBD liposome immobilized on the surface of the composite material was studied using antioxidant activity in the desorption bath. The prepared CBD liposome functionalized tampon additionally shows higher biodegradability compared to references. This high-quality, biodegradable sanitary material based on microencapsulated CBD components as a functional coating provides a platform for many different applications besides medical textiles, also for packaging, pharmaceuticals, paper and wood-based materials, etc.
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Bozic, Aleksandra, Nenad Filipovic, Irena Novakovic, Snezana Bjelogrlic, Jasmina Nikolic, Sasa Drmanic, and Aleksandar Marinkovic. "Synthesis, antioxidant and antimicrobial activity of carbohydrazones." Journal of the Serbian Chemical Society 82, no. 5 (2017): 495–508. http://dx.doi.org/10.2298/jsc161220045b.
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Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide?water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone.
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Kishkentayeva, А. S., S. N. Mantler, М. М. Zhakanov, and S. М. Adekenov. "Biologically active substances from Achillea nobilis L." Bulletin of the Karaganda University. "Chemistry" series 100, no. 4 (December 30, 2020): 52–59. http://dx.doi.org/10.31489/2020ch4/52-59.
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The review summarizes data on biologically active compounds of Achillea nobilis L. and methods of their isolation. From Achillea nobilis L., collected in different places of growth, the following have been isolated: essential oil, the main components of which are monoterpene compounds; sesquiterpene lactones estafiatin, hanphyllin, anobin, chrysartemine A, canin, anolide and tanapartin-β-peroxide; the steroid acetyleucanbin; flavonoids: 3,5-dihydroxy-6,7,8-trimethoxyflavone, 5-hydroxy-3,6,7,4’-tetramethoxyflavone and 5,3’-di-hydroxy-3,6,7,4’-tetramethoxyflavone. It has been determined that the component composition of the essen-tial oil of Achillea nobilis L. largely depends on the soil and climatic factors in the places of its growth, the phase of the growing season and the method of its extraction from plant raw materials, and the extractant used (chloroform, ethanol, hot water, diethyl ether). Antibacterial, antimicrobial, antioxidant, antiparasitic activi-ties are characteristic both for the sums of extractive substances from Achillea nobilis L. and for individual compounds isolated from them. Methods for the isolation of biologically active substances from Achillea nobilis L. for the development of new drug substances are described. The main aim of this work was a com-parative analysis of the available research results on the phytochemical study of Achillea nobilis L.
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Protsenko, L., M. Liashenko, A. Vlasenko, T. Hryniuk, and O. Dobrovolny. "Investigation of properties of biologically active substances and their content in cones of ukrainian hop varieties." Agricultural Science and Practice 5, no. 2 (July 15, 2018): 52–63. http://dx.doi.org/10.15407/agrisp5.02.052.
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Introduction. According to the data of foreign studies, prenyl fl avonoids and bitter substances of hop have signifi cant antioxidant, antiviral, antimicrobial, anti-infl ammatory and anti-carcinogenic properties. Methods. A complex of the following methods was used: a monographic method, analysis, synthesis and comparison, mathematical-statistical and modern physical-chemical methods of determining qualitative indices of hop, special and common in hop-growing industry, which allowed obtaining scientifi cally valid results. Results. The modern level of knowledge about biologically active compounds of hop and their properties was analyzed, in particular, bitter substances and xanthohumol. The quantitative and qualitative content of bitter substances, essential oil and xanthohumol in hop varieties of Ukrainian, European and American breeding was studied. Among the Ukrainian varieties, the highest amount of xanthohumol was found in Ruslan and Xanthus varie- ties – 1.16 % and 1.06 % against dry substances respectively, and its minimal amount was detected in the cones of the bitter Alta variety. Among the European varieties, the highest amount of this substance is contained in the German variety HallertauerTaurus – 0.9–1.0 %, up to 1 % in the Czech variety Agnus and the English va- riety Admiral, with the content of 0.95 %–1.09 %. There is a strong correlation between the accumulation of xanthohumol and alpha acids in the formation and ripening of the cones. The maximal amount of xanthohumol is formed in the hop cones in the phase of complete technical ripeness. The content of this substance in hop cones depends on the breeding variety and is a varietal trait, genetically fi xed for each variety. The quantitative amount of xanthohumol may be one of biochemical criteria of identifying the variety. Conclusions. By their characteristics, the Ukrainian hop varieties correspond to the world’s analogues, namely, according to their bio- chemical and technological indices, hop varieties Klon-18 and Zlato Polissia correspond to the characteristics of the hop of the Czech Saaz variety, the biochemical indices of the bitter Alta variety correspond to the Ger- man variety Magnum, and such varieties as Slovianka and Zahrava exceed the world’s analogues considerably in the composition and quality of bitter substances and essential oils and are unique.
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Chioibas, Raul, Razvan Susan, Monica Susan, Ovidiu Mederle, Delia Berceanu Vaduva, Matilda Radulescu, Mircea Berceanu, et al. "Antimicrobial Activity Exerted by Total Extracts of Germander." Revista de Chimie 70, no. 9 (October 15, 2019): 3242–44. http://dx.doi.org/10.37358/rc.19.9.7526.
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In the present research, ethanolic and methanolic extracts of Teucrium polium (germander) were studied regarding the content of biologically active substances - in particular polyphenols - antioxidant activity and antibacterial activity. The extracts have been found to be rich in polyphenolic compounds, kaempferol and epichatechin have been found to be present in the highest concentrations. The antioxidant activity evaluated by the method of capturing the free radicals with DPPH revealed values close to those produced by the ascorbic acid. Antimicrobial activity was evaluated by the diffusimetric method and S. aureus and E. coli microorganisms were found to be the most sensitive while P. aeruginosa and fungal species were not sensitive.
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Peighambardoust, Seyed Hadi, Seyedeh Homa Fasihnia, Seyed Jamaleddin Peighambardoust, Mirian Pateiro, Rubén Domínguez, and José M. Lorenzo. "Active Polypropylene-Based Films Incorporating Combined Antioxidants and Antimicrobials: Preparation and Characterization." Foods 10, no. 4 (March 29, 2021): 722. http://dx.doi.org/10.3390/foods10040722.
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Development of polypropylene (PP) films incorporating antioxidant-antimicrobial agents can inhibit microbial growth and reduce undesirable deteriorating reactions and can preserve the quality of food. This study was aimed to use a combination of sorbic acid (SA), butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) to provide a synergistic effect at their reduced concentrations. A Combination of the additives was more effective in enhancing mechanical properties compared to their single state in film composition. The PP-2%SA-3%BHA film (T3) had the highest tensile strength (17.9 MPa) and the lowest elongation at break (7.1%) than other films. The fourier-transform infrared (FTIR) proposed physical mixing of active additives within PP-matrix. Scanning electron microscopy showed uniform dispersion of the additives in PP-2%SA-1%BHT-1%BHA film (T4) compared to others. BHT containing films decreased the storage and loss moduli leading to weakening of film viscoelastic behaviour and reducing film melting point. The prepared active films showed higher antioxidant activity than control PP-film following an order of T4 > T2 > T3 corresponding to DPPH radical scavenging values of 89.1, 83.4 and 79.1%, respectively. All active films inhibited gram-negative and gram-positive bacteria growth. The results of this study indicated that the prepared active films possess desirable mechanical, thermal, antioxidant and antimicrobial properties enabling their use in food packaging.
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Peršin, Zdenka, Matej Ravber, Karin Stana Kleinschek, Željko Knez, Mojca Škerget, and Manja Kurečič. "Bio-nanofibrous mats as potential delivering systems of natural substances." Textile Research Journal 87, no. 4 (July 21, 2016): 444–59. http://dx.doi.org/10.1177/0040517516631323.
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Considering the increasing resistance of numerous bacteria to antibiotics, a novel wound dressing material was developed with naturally acquired olive leaf extract, which shows not only good antimicrobial activity, but also very good antioxidant activity. Besides that, the leaves are treated as waste in agriculture, giving an impact on waste management. An environmentally friendly procedure, electrospinning, was used for the first time to prepare polysaccharide nanofibrous mats with incorporated olive leaf extract, with the unique property of releasing the active phenolic components in a prolonged manner over 24 hours. The developed electrospun mats were characterized using scanning electron microscopy, high-performance liquid chromatography and ultraviolet-visible spectroscopy for determination of free radical scavenging activity by 2,2-diphenyl-1-picrylhydrazyl, antimicrobial testing and release kinetics. Antimicrobial tests have shown that electrospun mats with olive leaf extract achieve reduction towards the tested microorganisms: Staphylococcus aureus (G+), Escherichia coli (G-), Enterococcus faecalis (G+) and Pseudomonas aeruginosa (G-), while the high antioxidant activity of olive leaf extract was preserved during the electrospinning procedure. Release of olive leaf extract from electrospun mats was mathematically modeled, and the release kinetics evaluation indicates the appropriateness of the Korsmeyer–Peppas model for fitting the obtained results of release ability due to erosion of polysaccharide nanofiber mats.
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Chzhu, Olga P., Daredzhan E. Araviashvili, and Irina G. Danilova. "Studying Properties of Prospective Biologically Active Extracts from Marine Hydrobionts." Emerging Science Journal 4, no. 1 (February 1, 2020): 37–43. http://dx.doi.org/10.28991/esj-2020-01208.
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Biologically active substances (BAS) extracted from marine hydrobionts are characterized by high diversity and efficiency. They are represented by carotenoids, phospholipids, saponins and other compounds possessing high antioxidant (AOA), antitumor, immunomodulatory, radioprotective, and hypolipidemic activities. Because of extremely high marine BAS activity, the BAS dose necessary for treatment and prevention of many diseases is very small. The aim of present work was to assess biological properties of BAS complexes extracted from Black Sea marine inverterbrates for their following using in pharmacological preparations including liposomal drug delivery. BAS complexes were extracted from marine invertebrate tissues by two-phase extraction in combination with ultrasonication. Antioxidant activity of BAS extracts was determined with potassium permanganate discoloration method in an aqueous sulfuric acid medium. Antimicrobial activity was investigated by germination of BAS extracts. BAS influence on lymphocyte proliferative activity was studied with help of cytogenetic analysis. In this paper, the assessment of antioxidant, antimicrobial and mitogenic activities of biologically active complexes extracted from marine invertebrate tissues is presented. BAS properties in the oil and alcohol-water phases are compared. For the first time BAS complexes from Black Sea invertebrates are extracted by the resource-light method of two-phase extraction in combination with ultrasonication. Conditions for obtaining BAS extracts with optimal characteristics are proposed.
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Ghorbani, Ehsan, Arasb Dabbagh Moghaddam, Anousheh Sharifan, and Hossein Kiani. "Emergency Food Product Packaging by Pectin-Based Antimicrobial Coatings Functionalized by Pomegranate Peel Extracts." Journal of Food Quality 2021 (January 20, 2021): 1–10. http://dx.doi.org/10.1155/2021/6631021.
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Emergency food products (EFPs) or energy bars are used in critical situations, such as natural disasters, to promote crisis management. EFPs require sophisticated packaging strategies. Edible coatings incorporated with natural antimicrobial agents could be considered as active packaging materials for increasing EFP safety. In this study, pectin-based coatings incorporated with pomegranate peel extracts were used to protect energy bars. Initially, total phenolic contents and antimicrobial and antioxidant properties of aqueous and ethanolic pomegranate peel extracts (PPEs) were determined. Also, PPEs were analyzed by HPLC. In the next step, the extracts were incorporated into the matrix of edible coatings as active substances. The sensory properties and microbial contamination of coated energy bars were investigated during 30 days of storage. Sixteen phenolic substances were detected in the extracts with gallic acid, ellagic acid, caffeic acid, coumaric acid, and quercetin as major ingredients. The ethanolic extract exhibited higher concentrations for all phenolic compounds. The results indicated that the ethanolic extract showed inhibitory effects on S. aureus and E. coli at concentrations of 30 and 50 mg/ml, and the aqueous extract's inhibitory effects were observed at concentrations of 50 and 80 mg/ml, respectively. The antioxidant and antibacterial effects could be attributed to high phenolic content and a combination of different substances. Microbial and sensory tests performed on coated energy bars showed that the active coatings were able to control and reduce the population of microorganisms during storage without adversely affecting sensory properties.
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Sukhikh, Stanislav, Svetlana Noskova, Artem Pungin, Svetlana Ivanova, Liubov Skrypnik, Evgeny Chupakhin, and Olga Babich. "Study of the Biologically Active Properties of Medicinal Plant Cotinus coggygria." Plants 10, no. 6 (June 16, 2021): 1224. http://dx.doi.org/10.3390/plants10061224.
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The results of the studies have shown that to obtain an extract of a complex of biologically active substances of Cotinus coggygria, ethyl alcohol (mass fraction of alcohol 70%) with a hydromodule of 1:5 should be used, and the extraction should be carried out for 60 min at a temperature of 60 °C. The investigated plant extracts with the complex of bioactive substances from the Cotinus coggygria leaves and flowers are safe from the point of view of the content of heavy metals, pesticides, aflatoxin B1, radionuclides, as well as pathogenic and opportunistic microorganisms. It has been established that the Cotinus coggygria extract contains rutin, hyperoside, ferulic acid, quercetin, kaempferol, disulphuretin, sulphurein, sulphurein, gallic acid, methyl gallate, pentagalloyl glucose, 3,3′,4′,5,6,7-hexahydroxyflavonone, 3,3′,4′,5,5′,7-hexahydroxyflavonone, 3-O-α-L-rhamnofuranoside, 3,3′,4′,5,5′,7-hexahydroxyflavulium(1+), 7-O-β-D glucopyranoside, and 3,3′,4′,7-tetrahydroxyflavonone. The tested extracts have anticancer, antigenotoxic, and antimicrobial (against E. coli, S. aureus, P. vulgaris, C. albicans, L. mesenteroides) properties. The high antioxidant status of the tested extracts was established; the antioxidant activity of the samples was 145.09 mg AA/g (AA—ascorbic acid).
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Koudoro, Alain Y., Christian Tetede Rodrigue Konfo, Philippe Sessou, and Dominique C. K. Sohounhloue. "Status of research results in chemistry of biologically active substances in Benin." International Journal of Phytomedicine 10, no. 3 (November 19, 2018): 125. http://dx.doi.org/10.5138/09750185.2251.
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Research on biologically active chemicals extracted from medicinal plants and essential oils from aromatic plants in the West African subregion is booming. Recognition of the clinical, pharmaceutical and economic value of herbal medicines continues to grow despite the growth of the pharmaceutical industry and the continued development of new, more effective synthetic and biological medical products. On the other hand, despite the improvement in food preservation technics, food preservatives nature remains one of the most important issues for public health. Indeed, several synthetic preservatives have been banned in some countries because of their long-term adverse toxicological effects. The current trend of consumers to seek for a more natural diet has prompted the research, development and application of new natural products with antimicrobial and antioxidant activities in order to use them as alternatives to synthetic preservatives. This review aims to do an inventory of the results of research in chemistry of biologically active substances in Benin.
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Mrđan, Gorana, Borko Matijević, Sanja Vlaisavljević, Đenđi Vaštag, and Suzana Apostolov. "Study of antioxidant activity of selected monocarbohydrazone derivatives." Zastita materijala 62, no. 1 (2021): 5–8. http://dx.doi.org/10.5937/zasmat2101005m.
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Many of carbohydrazone derivatives have shown a wide range of biological activities. In previous studies, these compounds have proven to be excellent anti-cancer, antitumor, antibacterial, antimicrobial and antioxidant agents. Monocarbohydrazones, as one of the carbohydrazone derivatives, have been slightly explored. Due to that reason, in this study, eight newly synthesized monocarbohydrazones were subjected to examinations by the use of three antioxidant tests. To determine the effectiveness of monocarbohydrazone as potential radical scavengers, DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (Ferric Reducing Antioxidant Power) assays were used. The obtained results could open the door for further studies of these compounds as biologically active substances.
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Rodrigo, Dolores, and Alfredo Palop. "Applications of Natural Antimicrobials in Food Packaging and Preservation." Foods 10, no. 3 (March 9, 2021): 568. http://dx.doi.org/10.3390/foods10030568.
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In the food science field, the term “antimicrobial” basically refers to active substances of synthetic or natural origin, that are directly or indirectly present in a specific food, packaging material or food contact surface that affect the viability or the growth of microorganisms in that matrix [...]
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Goulas, Vlasios, Loukas Hadjivasileiou, Alexandra Primikyri, Christodoulos Michael, George Botsaris, Andreas G. Tzakos, and Ioannis P. Gerothanassis. "Valorization of Carob Fruit Residues for the Preparation of Novel Bi-Functional Polyphenolic Coating for Food Packaging Applications." Molecules 24, no. 17 (August 30, 2019): 3162. http://dx.doi.org/10.3390/molecules24173162.
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The food industry has become interested in the development of innovative biomaterials with antioxidant and antimicrobial properties. Although several biopolymers have been evaluated for food packaging, the use of polyphenolic coatings has been unexplored. The purpose of this work was to develop an antioxidant and antimicrobial coating for food packaging through the polymerization of carob phenolics. At first, the polyphenolic coatings were deposited in glass surfaces polymerizing different concentrations of carob extracts (2 and 4 mg mL−1) at three pH values (7, 8 and 9). Results demonstrated that the coating produced at pH 8 and at a concentration of 4 mg mL−1 had the most potent antioxidant and antimicrobial potential. Then, the coating was applied directly on the salmon fillet (coating) and on the plastic container (active packaging). Peroxide and thiobarbituric acid-reactive substances (TBARS) methods were used to measure the potency to inhibit lipid oxidation in salmon fillets. Furthermore, the anti-Listeria activity of coatings was also assessed. Results showed a significant decrease of lipid oxidation during cold storage of salmon fillets for both treatments; the superiority of applied coating directly on the salmon fillets was also highlighted. Regarding the antimicrobial potency, the polyphenolic coating depleted the growth of Listeria monocytogenes after 10 days storage; while the active packaging had no effect on Listeria monocytogenes. Overall, we describe the use of low-cost carob polyphenols as precursors for the formation of bifunctional coatings with promising applications in food packaging.
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JITĂREANU, Alexandra, Gabriela TĂTĂRÎNGĂ, Ana-Maria ZBANCIOC, and Ursula STĂNESCU. "Toxicity of Some Cinnamic Acid Derivatives to Common Bean (Phaseolus vulgaris)." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 39, no. 2 (November 21, 2011): 130. http://dx.doi.org/10.15835/nbha3927183.
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Cinnamic acid derivatives are an important class of biologically active compounds, playing an important role in the plants’ development, but may also present a wide range of actions: antimicrobial, antioxidant, antiinflamatory, antitumoral. The present study investigated the toxicity of ten cinnamic acid derivatives on Phaseolus vulgaris, this being the first step in evaluating their pharmacotoxicological potential (usually, plant toxicity tests are used for ecotoxicity assessment, but they can also provide some useful general information about the toxic potential of a pharmaceutical substance to living organisms). The bean seeds were exposed to three different concentrations of each substance (28.6 μg/cm2, 57.3 μg/cm2, 114.6 μg/cm2). All the tests were conducted in Petri dishes, using an artificial substrate (Whatman filter paper) impregnated with the investigated compounds. The analyzed elements were seedling length, root length, percentage of seeds that developed into seedlings, fresh seedling weight and the total polyphenols content. The tested compounds showed phytotoxic effects, inhibiting the growth of the plants and the biosynthesis of polyphenols as compared to the control. The substances with high logP values showed greater phytotoxic potential, but to establish an exact correlation between hydrophobicity and toxicity of the molecules a QSAR analysis must be further done.
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Tong, Hoa Tieu, Phuong Thi Bach Vu, Kien Cong Duong, and Phuong Ngo Diem Quach. "Biologicalactivities of Gynostemma pentaphyllum (Thunb.) Makino." Science and Technology Development Journal - Natural Sciences 1, no. 6 (December 7, 2018): 49–57. http://dx.doi.org/10.32508/stdjns.v1i6.615.
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Gynostemma pentaphyllum Thunb. Makino is a common folk herb used in the treatment of diabetes, hyperlipidemia, cardiovascular, cancer… [1]. This research was conducted to evaluate some bioactivities of the plant such as antioxidant, antimicrobial activity, α-glucosidase and lipase inhibition. Results showed that the ethanol extract of G. pentaphyllum is more active than the folk medicine-aqueous extract. The antimicrobial activity by measuring the zone of inhibition, showed strongest inhibition to Pseudomonas (d = 6,670 mm); the antioxidant activity of ethanol extract tested by DPPH method showed IC50 = 0.317 mg/mL; the ethanol extract also showed outstanding α-glucosidase inhibition activities with IC50 = 0.181 mg/mL and lipase inhibition activity with IC50 = 2.968 mg/mL. The ethanol extract of G. pentaphyll contained active substance groups such as phenols, flavonoids, alkaloids and saponins. This research has proved the potential of G. pentaphyllum ethanol extract as a source of valuable medicine in the treatment of common diseases nowadays.
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Vargas Romero, Emeli, Loong-Tak Lim, Héctor Suárez Mahecha, and Benjamin M. Bohrer. "The Effect of Electrospun Polycaprolactone Nonwovens Containing Chitosan and Propolis Extracts on Fresh Pork Packaged in Linear Low-Density Polyethylene Films." Foods 10, no. 5 (May 17, 2021): 1110. http://dx.doi.org/10.3390/foods10051110.
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Fresh meat products are highly perishable and require optimal packaging conditions to maintain and potentially extend shelf-life. Recently, researchers have developed functional, active packaging systems that are capable of interacting with food products, package headspace, and/or the environment to enhance product shelf-life. Among these systems, antimicrobial/antioxidant active packaging has gained considerable interest for delaying/preventing microbial growth and deteriorative oxidation reactions. This study evaluated the effectiveness of active linear low-density polyethylene (LLDPE) films coated with a polycaprolactone/chitosan nonwoven (Film 1) or LLDPE films coated with a polycaprolactone/chitosan nonwoven fortified with Colombian propolis extract (Film 2). The active LLDPE films were evaluated for the preservation of fresh pork loin (longissimus dorsi) chops during refrigerated storage at 4 °C for up to 20 d. The meat samples were analyzed for pH, instrumental color, purge loss, thiobarbituric acid reactive substances (TBARS), and microbial stability (aerobic mesophilic and psychrophilic bacteria). The incorporation of the propolis-containing nonwoven layer provided antioxidant and antimicrobial properties to LLDPE film, as evidenced by improved color stability, no differences in lipid oxidation, and a delay of 4 d for the onset of bacteria growth of pork chops during the refrigerated storage period.
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Dyomshina, O. O., G. O. Ushakova, and L. M. Stepchenko. "The effect of biologically active feed additives of humilid substances on the antioxidant system in liver mitochondria of gerbils." Regulatory Mechanisms in Biosystems 8, no. 2 (April 28, 2017): 185–90. http://dx.doi.org/10.15421/021729.
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Mitochondria are organelles that are most sensitive to the action of stressors on any cell of the entire organism and exposure to chemicals which can cause its dysfunction and cell death in general. Especially sensitive to adverse conditions are liver mitochondria, where the processes of biotransformation of endogenous and exogenous metabolites are formed, not only in the liver, but also in other organs and tissues. Mitochondrial dysfunction can cause instant hepatic cytolysis and steatosis. Therefore, early detection of mitochondrial toxicity is important during preclinical studies of new pharmacological agents, as this will help avoid remote negative effects. The biologically active feed additive Humilid, a complex of humic acids known for their antidiarrheal, analgesic, immune-stimulating, and antimicrobial properties; shows a corrective effect on the activity of the lysosomal cathepsin; enhances the positive effect of hematopoiesis on hemoglobin and its quality indicators consisting of red blood cells; and activates the synthesis and accumulation of fibronectin expression that takes part in the formation of immunological protection of animals. The objective of our experiment was to determine the effect of complex biologically active feed additives based on humic substances on the biochemical indicators of the liver mitochondrial antioxidant system of Mongolian gerbils (Meriones unguiculatus Milne-Edwards, 1867). The experiment was conducted on mature (6 months) Mongolian gerbils. The data obtained showing the influence of the biologically active feed additives Humilid, alone or in combination with ascorbate and Eco-impulse Animal, on the antioxidant defense system of liver mitochondria of gerbils are presented in this article. The proven antioxidant effect of humic substances in the mitochondrial fraction of the liver which inhibits the accumulation of oxidized products in the cells is shown, confirmed by the decrease in the number of TBA-active products, catalase activation, and an increase in the concentration of cytochrome C. Also, an increase in the amount of cytochrome C, which is a direct participant in the mitochondrial respiratory chain and provides efficient electron transport, indicates the acceleration of energy supply processes. The functional activity of mitochondria was accompanied by increased activity of aspartate aminotransferase involved in the shuttle of malate-aspartate transport of electrons through the mitochondrial membrane. The results obtained indicate the positive reaction of gerbil liver mitochondria under the influence of the biologically active feed additives of humic substance.
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Srisuruthi, M. D., and R. Balasasirekha. "Shelf Life of Meat Using Edible Active Packaging Enriched Films." Indian Journal of Nutrition and Dietetics 57, no. 1 (January 3, 2020): 25. http://dx.doi.org/10.21048/ijnd.2020.57.1.24556.
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Packaging is one of the most important processes to preserve the quality of food. Edible polymer is an effective alternative to synthetic polymers. Active packaging is incorporating antimicrobials and/or antioxidants in packaging material. Application of these technologies can improve safety of foods. In this study active edible film was formulated and standardised with concentration of 2.25% of sodium alginate, 1% glycerol, 2% CaCl2. Meat was chosen as it is a widely used perishable food. Garlic, atibala and betel leaf were chosen as the sources of active compounds. Betel leaf extract infused films were found to be more acceptable over garlic and atibala infused films. Edible Films (EF) with varying concentrations of betel leaf extract was formulated namely EFS, EF10, EF20, EF30 and EF40. The impact of the extract infused films was studied for its physical and physico-chemical properties, sensory attributes, nutrient content and shelf life extension ability. Varying concentrations of betel leaf extract didn't influence the thickness of the film whereas the film with P.betel leaf extract showed higher grammature values than that of the film without antioxidants. There was a gradual increase in solubility and antioxidant activity as the concentration of P.betel leaf extract increased. The antioxidant activity of EF10, EF20, EF30 and EF40 are 37.12%, 38.48%, 42.37% and 42.89% respectively. Sensory evaluation indicated that EF20 and EF10 had good overall acceptability. Nutrient quality of EF40 was highest followed by the other three formulations EF30, EF20 and EF10 in decreasing fashion. EF20 had acceptable sensory attributes and also possessed better nutrient content with carotene 1.67 mg, iron 4.23 mg and calcium 0.29 g. The seven days total plate count study of meat packed with EF20 revealed higher bacterial count of 5.88±0.087 log CFU g-1 in control than the EF20 i.e., 3.32±0.081 log CFU g-1. The study concludes that the usage of plant based antioxidants and antimicrobials can be effective alternative replacing chemicals used as food packaging material for increasing the shelf life of a food product
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Odrobińska, Justyna, Magdalena Skonieczna, and Dorota Neugebauer. "PEG Graft Polymer Carriers of Antioxidants: In Vitro Evaluation for Transdermal Delivery." Pharmaceutics 12, no. 12 (December 3, 2020): 1178. http://dx.doi.org/10.3390/pharmaceutics12121178.
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The in vitro biochemical evaluation of the applicability of polymers carrying active substances (micelles and conjugates) was carried out. Previously designed amphiphilic graft copolymers with retinol or 4-n-butylresorcinol functionalized polymethacrylate backbone and poly(ethylene glycol) (PEG) side chains that included Janus-type heterografted copolymers containing both PEG and poly(ε-caprolactone) (PCL) side chains were applied as micellar carriers. The polymer self-assemblies were convenient to encapsulate arbutin (ARB) as the selected active substances. Moreover, the conjugates of PEG graft copolymers with ferulic acid (FA) or lipoic acid (LA) were also investigated. The permeability of released active substances through a membrane mimicking skin was evaluated by conducting transdermal tests in Franz diffusion cells. The biological response to new carriers with active substances was tested across cell lines, including normal human dermal fibroblasts (NHDF), human epidermal keratinocyte (HaCaT), as well as cancer melanoma (Me45) and metastatic human melanoma (451-Lu), for comparison. These polymer systems were safe and non-cytotoxic at the tested concentrations for healthy skin cell lines according to the MTT test. Cytometric evaluation of cell cycles as well as cell death defined by Annexin-V apoptosis assays and senescence tests showed no significant changes under action of the delivery systems, as compared to the control cells. In vitro tests confirmed the biochemical potential of these antioxidant carriers as beneficial components in cosmetic products, especially applied in the form of masks and eye pads.
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Motelica, Ludmila, Denisa Ficai, Anton Ficai, Ovidiu Cristian Oprea, Durmuş Alpaslan Kaya, and Ecaterina Andronescu. "Biodegradable Antimicrobial Food Packaging: Trends and Perspectives." Foods 9, no. 10 (October 11, 2020): 1438. http://dx.doi.org/10.3390/foods9101438.
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This review presents a perspective on the research trends and solutions from recent years in the domain of antimicrobial packaging materials. The antibacterial, antifungal, and antioxidant activities can be induced by the main polymer used for packaging or by addition of various components from natural agents (bacteriocins, essential oils, natural extracts, etc.) to synthetic agents, both organic and inorganic (Ag, ZnO, TiO2 nanoparticles, synthetic antibiotics etc.). The general trend for the packaging evolution is from the inert and polluting plastic waste to the antimicrobial active, biodegradable or edible, biopolymer film packaging. Like in many domains this transition is an evolution rather than a revolution, and changes are coming in small steps. Changing the public perception and industry focus on the antimicrobial packaging solutions will enhance the shelf life and provide healthier food, thus diminishing the waste of agricultural resources, but will also reduce the plastic pollution generated by humankind as most new polymers used for packaging are from renewable sources and are biodegradable. Polysaccharides (like chitosan, cellulose and derivatives, starch etc.), lipids and proteins (from vegetal or animal origin), and some other specific biopolymers (like polylactic acid or polyvinyl alcohol) have been used as single component or in blends to obtain antimicrobial packaging materials. Where the package’s antimicrobial and antioxidant activities need a larger spectrum or a boost, certain active substances are embedded, encapsulated, coated, grafted into or onto the polymeric film. This review tries to cover the latest updates on the antimicrobial packaging, edible or not, using as support traditional and new polymers, with emphasis on natural compounds.
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Grajek, Włodzimierz, Anna Olejnik, and Anna Sip. "Probiotics, prebiotics and antioxidants as functional foods." Acta Biochimica Polonica 52, no. 3 (August 5, 2005): 665–71. http://dx.doi.org/10.18388/abp.2005_3428.
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The term "functional foods" comprises some bacterial strains and products of plant and animal origin containing physiologically active compounds beneficial for human health and reducing the risk of chronic diseases. Among the best known functional compounds probiotics, prebiotics and natural antioxidants should be given as examples. These substances can be obtained by biotechnological methods and by extraction from plant or animal tissues.
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Shevchuk, O. M., S. P. Lukashuk, S. A. Feskov, S. L. Adzhiakhmetova, N. M. Chervonnaya, and I. A. Fedotova. "Biologically active substances of Helichrysum italicum (Roth) G.Don." Bulletin of the State Nikitsky Botanical Gardens, no. 133 (December 18, 2019): 70–79. http://dx.doi.org/10.36305/0513-1634-2019-133-70-79.
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The article provides data on a comparative study of the content and component composition of essential oil, the total content of antioxidants and flavonoids of two cultivars and two promising cultivar samples of Italian strawflower ( Helichrysum italicum (Roth) G. Don) grown on the Southern Coast of the Crimea in the collection of aromatic and medicinal plants of the Nikitsky Botanical Gardens. It has been found that the content of essential oil in the green weight of top of H. italicum varies from 0.1% of the wet weight (‘Crystal’ cultivar) to 0.2 (cultivar No. 5). The main components of ‘VIM’ cultivar essential oil are α-pinene and D-limonene, of ‘Crystal’ cultivar is neril acetate, of the sample No. 5 is α-pinene and rosiforiol, of the sample No. 158 is neryl acetate and γ-turmeric. A significant relative content of β-diketones (38%) in the essential oil of ‘Crystal’ cultivar was noted. The greatest amount of antioxidants (2.59 mg / g (in conversion to quercetin) and flavonoids (0.366%) in the inflorescences of Italian strawflower ‘VIM’ cultivar is contained in the budding phase. The results of chromatographic analysis prove the presence of 4 phenolic substances in the inflorescences of Italian strawflower. UV-spectra of alcohol solutions of the studied raw materials had a maximum absorption at a wavelength of 418 ± 2nm. Quantitative determination of flavonoids by differential spectroscopy calculated as isosalipurposide showed that the content of flavonoids in inflorescences varies from 0.262% to 0.366% depending on a cultivar and a phase of vegetation.
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Pepper, Amber N., Panida Sriaroon, and Mark C. Glaum. "Additives and preservatives: Role in food allergy." Journal of Food Allergy 2, no. 1 (September 1, 2020): 119–23. http://dx.doi.org/10.2500/jfa.2020.2.200014.
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Food additives are natural or synthetic substances added to foods at any stage of production to enhance flavor, texture, appearance, preservation, safety, or other qualities. Common categories include preservatives and antimicrobials, colorings and dyes, flavorings, antioxidants, stabilizers, and emulsifiers. Natural substances rather than synthetics are more likely to cause hypersensitivity. Although rare, food additive hypersensitivity should be suspected in patients with immunoglobulin E (IgE)-mediated reactions to multiple, unrelated foods, especially if the foods are prepared outside of the home or when using commercial products. A complete and thorough history is vital. Skin prick testing and/or specific IgE blood testing to food additives, if available, additive avoidance diets, and blind oral challenges can help establish the diagnosis. Once an allergy to a food additive is confirmed, management involves avoidance and, if necessary, carrying self-injectable epinephrine.
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Gacheva, Gergana, and Liliana Gigova. "Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance." Open Life Sciences 9, no. 12 (December 1, 2014): 1168–81. http://dx.doi.org/10.2478/s11535-014-0350-x.
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AbstractThe escalating levels of antibiotic resistance among pathogenic bacteria and the side effects of chemotherapeutic drugs in use forced the efforts of scientists to search for natural antimicrobial and anticancer substances with novel structures and unique mechanism of action. Focusing on bioproducts, recent trends in drug research have shown that microalgae (including the cyanobacteria) are promising organisms to furnish novel and safer biologically active compounds. Many microalgal metabolites have been found to possess potent antibacterial, antifungal, antiviral, anticancer and antiinflammatory activities, as well as antioxidant, enzyme inhibiting and immunostimulating properties. In this paper, the studies on the biological activity of microalgae associated with potential medical and pharmaceutical applications are briefly presented. Attention is focused on the impact of cultivation temperature, irradiance and growth stage on the biomass accumulation, activity and pathways of cell metabolism and the possibilities of using these variable factors to increase the diversity and quantity of biologically active substances synthesized by microalgae.
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Khramova, Yelena Petrovna, Yelena Vasil'yevna Bogolyubova, Tat'yana Ablulhailovna Kukushkina, Tat'yana Mihajlovna Shaldaeva, and Galina Kimovna Zvereva. "PHYTOCHEMICAL STUDY OF TRIFOLIUM PANNONICUM JACQ. IN THE FOREST-STEPPE OF WESTERN SIBERIA." chemistry of plant raw material, no. 2 (June 10, 2020): 149–58. http://dx.doi.org/10.14258/jcprm.2020026023.
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The article presents data on the content of biologically active compounds and the total activity of phenolic antioxidants in the leaves and inflorescences of the valuable forage plant Trifolium pannonicum Premier cultivar grown in different agroclimatic subareas of the Novosibirsk region – moderately warm, moist and moderately warm, not sufficiently moist. It is shown that, depending on the plant growth, biologically active substances are synthesized in differently: the content of flavonols, catechins, carotenoids and pectin substances is 1.1–1.6 times higher in plants from a more humid area. Tannins maximally (up to 17.43%) accumulate in the leaves of T. pannonicum, grown in an area with insufficient moisture. All samples of T. pannonicum variety Premier are characterized by high antioxidant activity of ethanol extracts from leaves and inflorescences (1.50–2.20 mg/g). The maximum of the total activity of antioxidants was found in the inflorescences of T. pannonicum from an area with insufficient moisture. Plant material T. pannonicum variety Premier is characterized by a fairly high content of biologically active substances.
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Farkhutdinova, A. R., and M. T. Sabitov. "Feed additive based on biologically active substances for fattening steers." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 7 (July 1, 2021): 58–65. http://dx.doi.org/10.33920/sel-05-2107-06.
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The modern agricultural market offers a wide range of products designed for a highly effective and most importantly safe increase in growth indicators, the level of development and the degree of productivity of domestic animals. The leading role in achieving the highest quality result is played by a competent choice of feed additives. The purpose of the research was to study the use of a feed additive based on biologically active substances (BAS) in the fattening of steers. The effect of the feed additive based on a natural, balanced, natural complex of biologically active substances such as vitamins B, C, PP, tryptophan (with oral administration bioavailability reaches 90 %), antioxidants, essential and free amino acids, enzymes and trace element salts on the growth and development of young cattle of Black-and-White breed has been studied. The steers of the control group received the main diet, and the animals of the experimental group in addition to the main diet received the feed additive consisting of vitamins, amino acids, antioxidants, enzymes and trace element salts. It has been found by the studies that the use of the test feed additive based on BAS provides an improvement in the digestibility and assimilation of nutrients in the diet, which contributed to the increase in the average daily live weight gain in the experimental group by 263 g or 25 %, the decrease in feed consumption for 1 kg of gain and the improvement in blood biochemical parameters, such as inorganic phosphorus, AST, ALT, alkaline phosphatase within physiological norms. In order to balance the diets of 9-monthold steers by biologically active substances and improve the physiological and biochemical status, the digestibility of nutrients that contribute to the increase in the average daily weight gain, it is recommended to use the feed additive based on BAS with drinking water.
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Maslennikov, Pavel, Mikhail Zorin, and Anna Seregina. "Analysis of the bioavailability of tea species." E3S Web of Conferences 291 (2021): 02005. http://dx.doi.org/10.1051/e3sconf/202129102005.
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In samples of different tea brands the content of biologically active substances (total water-soluble antioxidants content, ascorbic acid, rutin, polyphenols, anthocyanins) was determined. The water-soluble antioxidant biological availability of the studied tea samples was evaluated. Green Tea with Lemon and Ceylon Baikhovi Black Spiced Tea is characterized by similar levels of antioxidant bioavailability. After the consumption of both beverages, there was a definite increase in the content of antioxidants in saliva of individuals with an initially low content of antioxidants. Amaranth Phytotea antioxidants were characterized by low level of bioavailability. The consumption of this beverage did not change the level of antioxidants in saliva, regardless of their initial content.
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Hricovíniová, Zuzana, Šárka Mascaretti, Jana Hricovíniová, Alois Čížek, and Josef Jampílek. "New Unnatural Gallotannins: A Way toward Green Antioxidants, Antimicrobials and Antibiofilm Agents." Antioxidants 10, no. 8 (August 13, 2021): 1288. http://dx.doi.org/10.3390/antiox10081288.
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Nature has been a source of inspiration for the development of new pharmaceutically active agents. A series of new unnatural gallotannins (GTs), derived from d-lyxose, d-ribose, l-rhamnose, d-mannose, and d-fructose have been designed and synthesized in order to study the protective and antimicrobial effects of synthetic polyphenols that are structurally related to plant-derived products. The structures of the new compounds were confirmed by various spectroscopic methods. Apart from spectral analysis, the antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging and iron reducing power (FRAP) assays. Antibacterial activity of compounds was tested in vitro against Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 (reference and control strains), three methicillin-resistant isolates of S. aureus, and three isolates of vancomycin-resistant E. faecalis. For screening of antimycobacterial effect, a virulent isolate of Mycobacterium tuberculosis and two non-tuberculous mycobacteria were used. Furthermore, antibiofilm activity of structurally different GTs against S. aureus, and their ability to inhibit sortase A, were inspected. Experimental data revealed that the studied GTs are excellent antioxidants and radical-scavenging agents. The compounds exhibited only a moderate antibacterial effect against Gram-positive pathogens S. aureus and E. faecalis and were practically inactive against mycobacteria. However, they were efficient inhibitors and disruptors of S. aureus biofilms in sub-MIC concentrations, and interacted with the quorum-sensing system in Chromobacteriumviolaceum. Overall, these findings suggest that synthetic GTs could be considered as promising candidates for pharmacological, biomedical, consumer products, and for food industry applications.
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Uzakov, Yasin, Madina Kaldarbekova, and Olga Kuznetsova. "Improved technology for new-generation Kazakh national meat products." Foods and Raw Materials 8, no. 1 (February 26, 2020): 76–83. http://dx.doi.org/10.21603/2308-4057-2020-1-76-83.
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Introduction. Extract of goji berries (Lycium Barbarum L.) and buckwheat flour (Fagopýrum esculéntum L.) possess antioxidant and antimicrobial properties. As a result, they can be used to improve traditional Kazakh horse-meat formulations to obtain functional cooked and smoked meat products. These natural biologically active substances can improve the oxidative stability of pigments, lipids, and proteins of finished products. The research objective was to assess the potential of goji extract and buckwheat flour as additives that can improve the oxidative stability and general quality of Kanagat, a national Kazakh cooked and smoked horse-meat product. Goji extract and buckwheat flour were used in two concentrations – 0.5% and 1.0%.
Study objects and methods. The research featured sensory evaluation of taste, smell, color, determination of color parameters (L*, a*, b*), pH, free amine nitrogen, total carbonyl proteins, acid value, peroxide value and thiobarbituric acid reactive substances (TBARS), as well as a histological analysis.
Results and discussion. When 1.0% of goji extract and 1.0% of buckwheat flour were added to the traditional formulation, it improved the oxidative stability and quality of the modified horse-meat product while preserving its sensory properties and colour parameters. A set of microstructural studies showed that the processing of meat products with 1.0% of goji extract and 1.0% of buckwheat flour had a destructive effect on most fibers. The affected fibers showed multiple decays of myofibrillar substance, which turned into a finegrained protein mass. The abovementioned concentration caused effective inhibition of hydrolytic changes, as well as oxidation of proteins and lipids.
Conclusion. The new technology made it possible to produce a new national horse-meat product fortified with 1.0% of goji extract and 1.0% of buckwheat flour. The specified amount of biologically active additives improved the oxidative stability and quality of the product, while maintaining its sensory and color characteristics.
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Ushakova, O. V., A. V. Molchanova, and L. L. Bondareva. "Content of biologically active substances in seedlings of cabbage of the genus Brassica L." Vegetable crops of Russia, no. 1 (March 5, 2021): 96–104. http://dx.doi.org/10.18619/2072-9146-2021-1-96-104.
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Relevance. Photosynthetic seedlings, as a model object, are interesting both in the study of nutritional value and the species response of a plant organism to the cultivation.Material and methods. The study was carried out on the basis of the laboratory analytical department of the FSBSI FSVC. The material of the research was sprouts of Brassica chinensis L., cv. Vesnyanka; Brassica oleraceae L. var. italica Plenck, cv. Tonus; Brassica oleracea L. convar. acephala DC., cv. Malinovka; Brassica oleracea var. gongylodes L., hybrid F1 Sonata and cv. Venskaya Belaya 1350; Brassica oleracea L. convar. capitata (L.) Alef. var. capitata L. f. rubra (L.) Thell., cv. Gako 741. The seeds of the 2018 harvest were germinated in filter paper cassettes using distilled water. The cassettes with seeds were placed in a thermostat under constant illumination and a temperature of 25°C. They have been germinated for 8 days, after which a biochemical analysis of the samples was carried out.Results. It was found out that the total content of water-soluble antioxidants in the studied of cabbage crops was in the range of concentrations from 3.58-4.57 mg-eq HA/g (wet weight). According to this indicator of 8-day-old seedlings, red cabbage variety Gako 741 was distinguished by the maximum values. The total content of antioxidants in the alcoholic extract ranged from 21.24 to 28.23 mg-eq HA/g (dry weight). The content of polyphenols – in the concentration range of 16.39-24.94 mg-eq of HA/g (dry weight). As a result of the research, direct correlations of the studied characteristics were revealed. A high correlation was shown between the content of water-soluble antioxidants and dry matter (r=0.72...0.98) and between the content of carotenoids and chlorophylls (r=0.98...0. 99).
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Petrova, Svetlana N., Anastasiya D. Kantan, and Yuliya V. Yargunova. "PREPARATION AND PROPERTIES OF RED CURRANT LEAVES EXTRACTS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 7 (August 24, 2017): 66. http://dx.doi.org/10.6060/tcct.2017607.5444.
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The work is devoted to biological active substances in plants and their antioxidant activity. The study of biologically active substance, especially natural antioxidants is very important task. After several studies on the importance of antioxidants in biological systems by counteracting of oxidative stress that causes several human diseases such as atherosclerosis, diabetes mellitus, chronic inflammation, neurodegenerative disorders, and certain types of cancer have been conducted. There is a great interest of quantification of antioxidants and determination of antioxidant capacities of a number of specific food compounds. The main theme of work includes three subthemes. The first subtheme is the preparation of the extract; the second subtheme is the study of the composition of biologically active substances contained in the extract; and the third subtheme is the study of the properties of the extract. The primary objective of the investigation is to research properties of thick extracts of red currant leaves which were extracted with such organic solvents as acetone, hexane and ethyl alcohol. The tasks are qualitative and quantitative investigation of the thick extracts and determination of their inhibiting action on the process of free radicals formation in hydrophilic systems. For the qualitative analysis of thick extracts the method of optical spectroscopy is employed. Calculation method is used for the quantitative analysis. The most important stage of analyzing dense extracts is the verification of their antioxidant properties. This model of the oxidation reaction of adrenaline with air oxygen is used. The theoretical importance is application of the natural vegetable materials as the source of antioxidants for food stuffs. In comparison with synthetic materials they are less toxic. To sum it up, red currant leaves extracts contain a set of biological active substances (phenolic compounds, bioflavonoids, carotinoids, chlorophyll) capable of exerting an antioxidant effect, and they can be recommended in the food, cosmetic and pharmaceutical industries.Forcitation:Petrova S.N., Kantan A.D., Yargunova Yu.V. Preparation and properties of red currant leaves extracts. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 7. P. 66-71.
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Yang, Yong, Lyudmila Asyakina, Olga Babich, Lyubov Dyshluk, Stanislav Sukhikh, Alexander Popov, and Nina Kostyushina. "Physicochemical properties and biological activity of extracts of dried biomass of callus and suspension cells and in vitro root cultures." Food Processing: Techniques and Technology 50, no. 3 (October 12, 2020): 480–92. http://dx.doi.org/10.21603/2074-9414-2020-3-480-492.
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Introduction. One of the urgent problems of medicine and biology is the use of plant objects as industrial producers of target metabolites in vitro. In vitro cells can be used as pharmaceutical preparations.
Study objects and methods. The present research featured medicinal plants that grow in the Siberian Federal district and are a popular source of medicinal raw materials. The physicochemical properties, e.g. total ash content in extracts, the content of heavy metals, the content of organic solvents in the extracts, and the mass loss upon drying was determined by standard methods. The antimicrobial properties of in vitro extracts were determined by the diffusion method and the method based on optical density measurement. The list of opportunistic and pathogenic test strains included the following microorganisms: E. coli ATCC 25922, S. aureus ATCC 25923, P. vulgaris ATCC 63, P. aeruginosa ATCC 9027, and C. albicans EMTC 34. The number of viable cancer cells was determined using the MTT colorimetric method.
Results and discussion. The paper describes the physicochemical properties, safety indicators, antioxidant activity, antimicrobial activity, and antitumor properties of extracts of a complex of biologically active substances obtained in vitro from the dried biomass of callus and suspension cell cultures and root cultures. The root extracts proved to have the maximum antimicrobial and cytotoxic properties. They could reduce the survival rate of cancer cells to 24.8–36.8 %.
Conclusion. The research featured extracts obtained from the dried biomass of callus and suspension cell cultures and root cultures in vitro of safflower leuzea (Leuzea carthamoides L.), Rhodiola rosea (Rhodiola rosea L.), various sorts of skullcap (Scutellaria baicalensis L., Scutellaria andrachnoides L., Scutellaria galericulata L.), Potentilla alba (Potentilla alba L.) and ginseng (Panax L.). The results showed that the extracts can be used for the production of pharmaceuticals and biologically active additives with antitumor, antimicrobial, and antioxidant properties.
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MÁRQUEZ FERNÁNDEZ, Diana Margarita. "Nanoencapsulation of bioactive ingredients: trends in pharmaceutical industry and functional foods." Vitae 26, no. 2 (November 7, 2019): 66–67. http://dx.doi.org/10.17533/udea.vitae.v26n2a01.
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Multiple researches have allowed the development of nanoencapsulation techniques that ease the controlled or targeted release of bioactive components and favor their incorporation in different foods and medication formulations to improve their bioavailability. Recent studies have facilitated the development of nanoencapsulation systems of different active ingredients for functional foods, comprising phenolic compounds, antioxidants, essential oils, minerals, flavors, fish oils, essential fatty acids, vitamins, antimicrobials, soluble fiber, peptides, lycopene, lutein, β-carotene, phytosterols, iron, calcium, among others, as well as bioactive compounds for therapeutic applications as polyphenols, curcumin, quercetin, resveratrol and epigallocatechin-3-gallate.
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Averyanova, Elena Vital'yevna, Marina Nikolayevna Shkolnikova, Evgeniy Dmitriyevich Rozhnov, Denis Viktorovich Minakov, Evgeniy Sergeyevich Batashov, and Bakyt Kaliaskarovna Shaikhova. "INVESTIGATION OF THE BIOLOGICAL ACTIVITY OF SEA BUCKTHORN MEAL FLAVONOIDS USING SPECIFIC BIOTEST SYSTEMS." chemistry of plant raw material, no. 4 (December 21, 2020): 235–41. http://dx.doi.org/10.14258/jcprm.2020048859.
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The need to expand the raw material base for obtaining flavonoids is due to the wide spectrum of their biological activity. The purpose of this work is to study the biological activity of a complex of bioflavonoids, quercetin and rutin on specific enzyme biotest systems in vitro. The objects of the study were: a complex of bioflavonoids from fat-free sea buckthorn meal Hippophae rhamnoides L. and individual flavonoids rutin and quercetin isolated from it. The study was carried out by methods of detecting the biological activity of substances using specific enzyme biotest systems in vitro. It was revealed that rutin and a complex of bioflavonoids have antioxidant properties – the rate of glutathione reductase reaction increased by 64 and 51% of control, respectively, and catalase – by 15%. Quercetin exhibits antimicrobial activity and also reduces the rate of the enzymatic iNOS reaction by 24% of the control, which indicates the anti-inflammatory properties of this sample. Rutin and a complex of bioflavonoids from sea buckthorn meal increased the iNOS reaction rate by 14 and 28%, respectively, which indicates the immunostimulating properties of these samples. In the course of a microbiological study, it was found that all samples have weak bacteriostatic activity against gram-positive and gram-negative bacteria Staphylococcus aureus ATCC 6538 (209-P) and Pseudomonas aeruginosa ATCC 9027. Fungistatic activity was confirmed against the yeast-like fungi Candida albicans ATCC 10231 of quercetin and the complex. The results obtained make it possible to consider a complex of bioflavonoids, quercetin and rutin as promising active substances in antioxidant, antimicrobial, fungistatic and anti-inflammatory drugs.