Relevant bibliographies by topics / Active Class

Academic literature on the topic 'Active Class'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Active Class"

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Pantoli, L., V. Stornelli, and G. Leuzzi. "Class AB tunable active inductor." Electronics Letters 51, no. 1 (January 2015): 65–67. http://dx.doi.org/10.1049/el.2014.3877.

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Bailey, Raymond C., and Noel C. Eggleston. "Active Learning and the Survey Class." Teaching History: A Journal of Methods 12, no. 2 (May 4, 1987): 3–9. http://dx.doi.org/10.33043/th.12.2.3-9.

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Subowo,, Arif, Triyanto Triyanto,, and Rini Triastuti. "Active Debate Learning Model in Strengthening Critical Thinking Skills for Class IX students." International Journal of Multidisciplinary Research and Analysis 05, no. 11 (November 15, 2022): 3100–3105. http://dx.doi.org/10.47191/ijmra/v5-i11-17.

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The ability to think critically is an important component in the world of education, especially for students as the younger generation should have the ability to think critically as a capital to face the challenges of the world in the future. This study aims to determine the strengthening of critical thinking skills of grade IX students through an active debate learning model on Pancasila and citizenship education subjects at Muhammadiyah Junior High School Special Program Kottabarat Surakarta. This study uses a qualitative approach with data collection through observation, interviews and documentation. The subjects of this study were teachers of Pancasila and citizenship education and grade IX students. The results showed that the application of the ac tive debate learning model in Pancasila and citizenship education subjects was able to strengthen the critical thinking skills of grade IX students, indicated by the students' ability to understand the material, analyze, speak, and conclude a problem.
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Xue, Yanbing, and Milos Hauskrecht. "Active Learning of Multi-Class Classification Models from Ordered Class Sets." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 5589–96. http://dx.doi.org/10.1609/aaai.v33i01.33015589.

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In this paper, we study the problem of learning multi-class classification models from a limited set of labeled examples obtained from human annotator. We propose a new machine learning framework that learns multi-class classification models from ordered class sets the annotator may use to express not only her top class choice but also other competing classes still under consideration. Such ordered sets of competing classes are common, for example, in various diagnostic tasks. In this paper, we first develop strategies for learning multi-class classification models from examples associated with ordered class set information. After that we develop an active learning strategy that considers such a feedback. We evaluate the benefit of the framework on multiple datasets. We show that class-order feedback and active learning can reduce the annotation cost both individually and jointly.
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Lindholm, J. "First Class Ideas: Creating an Atmosphere Conducive To Active Class Participation." Journal of Management Education 12, no. 3 (August 1, 1988): 110–12. http://dx.doi.org/10.1177/105256298801200316.

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Marquette, Christopher J., and Thomas G. E. Williams. "Dual-Class Shares and Active Investment Strategies." Journal of Investing 20, no. 1 (February 28, 2011): 43–51. http://dx.doi.org/10.3905/joi.2011.20.1.043.

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Bratanov, Vasil, Frank Jenko, and Erwin Frey. "New class of turbulence in active fluids." Proceedings of the National Academy of Sciences 112, no. 49 (November 23, 2015): 15048–53. http://dx.doi.org/10.1073/pnas.1509304112.

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Turbulence is a fundamental and ubiquitous phenomenon in nature, occurring from astrophysical to biophysical scales. At the same time, it is widely recognized as one of the key unsolved problems in modern physics, representing a paradigmatic example of nonlinear dynamics far from thermodynamic equilibrium. Whereas in the past, most theoretical work in this area has been devoted to Navier–Stokes flows, there is now a growing awareness of the need to extend the research focus to systems with more general patterns of energy injection and dissipation. These include various types of complex fluids and plasmas, as well as active systems consisting of self-propelled particles, like dense bacterial suspensions. Recently, a continuum model has been proposed for such “living fluids” that is based on the Navier–Stokes equations, but extends them to include some of the most general terms admitted by the symmetry of the problem [Wensink HH, et al. (2012) Proc Natl Acad Sci USA 109:14308–14313]. This introduces a cubic nonlinearity, related to the Toner–Tu theory of flocking, which can interact with the quadratic Navier–Stokes nonlinearity. We show that as a result of the subtle interaction between these two terms, the energy spectra at large spatial scales exhibit power laws that are not universal, but depend on both finite-size effects and physical parameters. Our combined numerical and analytical analysis reveals the origin of this effect and even provides a way to understand it quantitatively. Turbulence in active fluids, characterized by this kind of nonlinear self-organization, defines a new class of turbulent flows.
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TORII, Shuichi, Yasuhiro IMAMURA, Yasutaka OHSHIMA, and Kouji ARIYOSHI. "Active Class Composed with Mechanical Engineering and Environment." Journal of JSEE 60, no. 4 (2012): 4_82–4_84. http://dx.doi.org/10.4307/jsee.60.4_82.

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Yang, Yanping, and Guangzhi Ma. "Ensemble-based active learning for class imbalance problem." Journal of Biomedical Science and Engineering 03, no. 10 (2010): 1022–29. http://dx.doi.org/10.4236/jbise.2010.310133.

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Rochmahwati, Pryla. "INTEGRATING ACTIVE LEARNING IN A COLLEGE SPEAKING CLASS." Journal on English as a Foreign Language 3, no. 1 (December 25, 2015): 31. http://dx.doi.org/10.23971/jefl.v3i1.60.

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Dissertations / Theses on the topic "Active Class"

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Barnabé-Lortie, Vincent. "Active Learning for One-class Classification." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33001.

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Active learning is a common solution for reducing labeling costs and maximizing the impact of human labeling efforts in binary and multi-class classification settings. However, when we are faced with extreme levels of class imbalance, a situation in which it is not safe to assume that we have a representative sample of the minority class, it has been shown effective to replace the binary classifiers with a one-class classifiers. In such a setting, traditional active learning methods, and many previously proposed in the literature for one-class classifiers, prove to be inappropriate, as they rely on assumptions about the data that no longer stand. In this thesis, we propose a novel approach to active learning designed for one-class classification. The proposed method does not rely on many of the inappropriate assumptions of its predecessors and leads to more robust classification performance. The gist of this method consists of labeling, in priority, the instances considered to fit the learned class the least by previous iterations of a one-class classification model. Throughout the thesis, we provide evidence for the merits of our method, then deepen our understanding of these merits by exploring the properties of the method that allow it to outperform the alternatives.
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Scott, Gillian. "The working class women's most active and democratic movement." Thesis, University of Sussex, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236239.

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Lloyd, Ben David, University of Western Sydney, and Faculty of Science and Technology. "Jets in Fanaroff-Riley class I radio galaxies." THESIS_FST_XXX_Lloyd_B.xml, 1997. http://handle.uws.edu.au:8081/1959.7/258.

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Presented here are observations, analysis and interpretation of five Fanaroff-Riley class I radio galaxies. Total intensity and polarised emission was observed in each source at 6 and 3 cm at angular resolutions of 16 to 2 arc seconds. These sources have a flux density greater than 1 Jy at 843 MHz, are 10-30 arc minutes in total angular extent, have redshifts between 0.011 and 0.035, are south of declination –43 degrees and have bright prominent jet structure. Images of the distribution of total intensity, polarised intensity and magnetic field configuration are presented and analysed. Physical properties in the jets and lobe are estimated using a number of different techniques. The observations have revealed a wide variety of structures, which imply many types of physical processes occurring in these sources, and different types of environments the jets travel through. The surface brightness distribution of some FR I radio galaxies with some characteristics of FR II galaxies are found to be consistent with the jets traveling through flat pressure gradients possibly caused by the presence of a cocoon surrounding the source. Analytical model imply jets with Mach numbers of 1-5, and jet velocities of approximately 1,000-20,000 km s-1 along most of the jets but mildly relativistic velocities 0.1-0.5c are indicated by Doppler boosting models at the base of most of the jets
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Dudolevitch, Robert Francis. "A cost comparison between active and naval reserve force FFG-7 class ships." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA272492.

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Thesis (M.S. in Management) Naval Postgraduate School, June 1993.
Thesis advisor(s): David R. Henderson ; Richard D. Milligan. "June 1993." Includes bibliographical references. Also available online.
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Farleigh, Laura Elizabeth. "Development of a new class of antivirals active against pox and measles viruses." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/63804/.

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In this PhD project we show for the first time that novel dideoxy bicyclic pyrimidine nucleoside analogues (ddBCNAs) with L-chirality represent promising antiviral candidates for use against pox and measles viruses. We suggest a mechanism of action based on a cellular target. Our lead compound (Cf2642, with side chain C9H18–O–C5H11) is active against vaccinia virus (a surrogate poxvirus for smallpox) and measles virus, with IC50 concentrations of 0.19 and 7.5 µM, respectively. This is a 60-fold enhancement over cidofovir (viral DNA polymerase inhibitor; IC50 of 11.5 µM against VACV). A structure activity relationship was established, which was similar for both viruses, indicating a common and specific mechanism of action. Cf2642 does not inhibit HSV-1/2, influenza, adeno or yellow fever viruses. The mechanism of action for the ddBCNAs has been investigated and, though not defined, has been narrowed down. Based on our observations of drug activity in cell lines derived from various sources, we have suggested a cellular target for the ddBCNAs, most likely cellular membrane compartments or the proteins located therein. Though inhibition of vaccinia is observed within two hours of infection, we have shown that the ddBCNAs are unlikely to be entry inhibitors. Acidification of the extracellular medium was observed but, whilst it may be linked to the mechanism of action, this is not the cause of the antiviral effects. With a possible cellular target, toxicity was carefully evaluated. We have not observed significant cytotoxicity in any of our cell models. Antivirals active against cellular targets are less subject to viral resistance, which may develop rapidly with virus-targeting drugs. This could be critical since, there are currently no effective measles antiviral drugs available on the market, and resistance to measles RNA polymerase inhibitors and the potential antipoxviral drug cidofovir has already been described.
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Tavasli, Mustafa. "Synthesis of a new class of homochiral amines and novel bio-active tropanes." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4552/.

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This thesis describes two main programmes: the synthesis of a new class of homochiral amines and the synthesis of ketone analogues of 3a-esterified tropane alkaloids. In chapter one, a scaled-up synthesis of (5)-a-(diphenylmethyl)pyrrolidine 1 is described. The key hydrogenation step of the oxazolidinone intermediate 2 was extended to the synthesis of the other chiral amines 70, 73, 76, 79 and 82. Hydrogenation of the oxazolidinones proceeded in good yields (71 - 87 %) and was not susceptible to racemisation. Thus, a convenient route from amino acid ester hydrochlorides (S)-valine 65, (S)-phenylalanine 66, (S)-alanine 67, (S)-isoleucine 68 and (S)-leucine 69 allowed a range of novel chiral amines to be prepared. In chapters two and three, a new route to ketone analogues of tropane esters is described. In chapter two, results of an attempt to prepare ketone 110 are outlined. Ketone 110 is an analogue of the tropane alkaloid littorine 101, where the bridging ester O atom is replaced by a CH2 group. The first approach to ketone 110 involved the Wittig reaction of acetylmethylenephosphorane 118 and the Homer-Wadsworth- Emmons reaction of diethylbenzoylmethanephosphonate 122 with tropinone 116. Tropinone 116 was found to be particularly unreactive in both cases. The second approach to ketone 110 involved the coupling reactions of both N-troc-3a- tosyloxymethyltropane 170 and N-troc-3 a-iodomethyltropane 185 with 2-phenylacetyl- 1,3-dithiane 147 and 1,3-ditihiane 142. These were also unreactive and as a result the synthesis of ketone 110 remains unresolved. In chapter three, the synthesis of other ketone analogues of naturally occurring 3 a- esterified tropane alkaloids is described. A six-step route to the ketones was devised and in this route the Grignard reactions of tropan-3 -ylacetaldehyde 227 emerged as the key to the success of the strategy. Three ketone analogues 218, 219 and 220 of tropate esters were successfully prepared. Ketone 220, the analogue of apoatropine 201, was found to be a muscarinic acetylcholine receptor antagonist (EC(_50) 1.9x10(^-7) M) in guinea-pigileum, showing a 500-fold less activity than atropine 202. However the activity is still within the clinical range.
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Imaeda, Yasuhiro. "Studies on Sulfonylalkylamides as a New Class of Orally Active Factor Xa Inhibitors." Kyoto University, 2009. http://hdl.handle.net/2433/124028.

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Englhardt, Adrian [Verfasser], and K. [Akademischer Betreuer] Böhm. "Cost-Quality Trade-Offs in One-Class Active Learning / Adrian Englhardt ; Betreuer: K. Böhm." Karlsruhe : KIT-Bibliothek, 2021. http://d-nb.info/1239180578/34.

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Saluke, Jessica Mary. "The Comparative Effects of Independent and Whole Class Active Student Response on Students’ Vocabulary Achievement in a High School Social Studies Class." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531220368893987.

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Huwiler, Simona G. [Verfasser], and Matthias [Akademischer Betreuer] Boll. "Structure and function of the tungsten-containing active site of class II benzoyl-CoA reductases." Freiburg : Universität, 2015. http://d-nb.info/1140735284/34.

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Books on the topic "Active Class"

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Blaser, Mark, Ted Clark, Liana Lamont, and Jaclyn J. Stewart, eds. Active Learning in General Chemistry: Whole-Class Solutions. Washington, DC: American Chemical Society, 2019. http://dx.doi.org/10.1021/bk-2019-1322.

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L, Silberman Melvin, ed. Active Jewish learning: 57 strategies to enliven your class. Los Angeles: Torah Aura, 2009.

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Campbell, Garry. Who's in charge?: Collaborating for class management in an active learning classroom. Mississauga, Ont: Peel Board of Education, 1991.

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Joshi, S. M. Robust stabilization of a class of passive nonlinear systems. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1996.

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Brossard, Michel. Les statuts de travail: Une analyse socio-institutionnelle de la population active québécoise. [Québec]: Gouvernement du Québec, Commission consultative sur le travail, 1986.

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Action learning in action: Transforming problems and people for world-class organizational learning. Palo Alto, Calif: Davies-Black Pub., 1999.

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Kushida, Michelle Mayumi. Identification of CIS-active targets of MHC class 1 transcritional downregulaton in tumour cells. Ottawa: National Library of Canada, 1996.

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E, Robichaux Paul, ed. Using MFC and ATL. Indianapolis, IN: QUE, 1997.

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The remedy: Class, race, and affirmative action. New York: BasicBooks, 1996.

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Class matters: Cross-class alliance building for middle-class activists. Gabriola Island, BC: New Society Publishers, 2005.

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Book chapters on the topic "Active Class"

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Attenberg, Josh, and Şeyda Ertekin. "Class Imbalance and Active Learning." In Imbalanced Learning, 101–49. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118646106.ch6.

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Vater, J. "Lipopeptides, an Interesting Class of Microbial Secondary Metabolites." In Biologically Active Molecules, 27–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74582-9_3.

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Tan, Ying, Hong Luo, and Shou-Li Peng. "Distribution of Node Characteristics in Complex Networks of Tree Class." In Active Media Technology, 451–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-35236-2_45.

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Körner, Christine, and Stefan Wrobel. "Multi-class Ensemble-Based Active Learning." In Lecture Notes in Computer Science, 687–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11871842_68.

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Wu, Dongrui, and Thomas D. Parsons. "Active Class Selection for Arousal Classification." In Affective Computing and Intelligent Interaction, 132–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24571-8_14.

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Chen, Jianhua. "A Scalable Boosting Learner for Multi-class Classification Using Adaptive Sampling." In Active Media Technology, 61–72. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-09912-5_6.

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Donovan, Deborah A., and Georgianne L. Connell. "Evolution of a Student-Centered Biology Class: How Systematically Testing Aspects of Class Structure Has Informed Our Teaching." In Active Learning in College Science, 307–23. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33600-4_20.

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Wang, Anran, Hongyuan Zhu, Jianfei Cai, and Jianxin Wu. "Multi-class Cosegmentation with Pairwise Active Learning." In Lecture Notes in Computer Science, 69–78. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-03731-8_7.

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Belouadah, Eden, Adrian Popescu, Umang Aggarwal, and Léo Saci. "Active Class Incremental Learning for Imbalanced Datasets." In Computer Vision – ECCV 2020 Workshops, 146–62. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-65414-6_12.

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Yasunaga, Satoru. "Class Design Based on High Student Engagement Through Cooperation: Toward Classes that Bring About Profound Development." In Deep Active Learning, 111–36. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5660-4_7.

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Conference papers on the topic "Active Class"

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Cao, Hong, Chunyu Bao, Xiao-Li Li, and Yew-Kwong Woon. "Class Augmented Active Learning." In Proceedings of the 2014 SIAM International Conference on Data Mining. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2014. http://dx.doi.org/10.1137/1.9781611973440.1.

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Pantoli, Leonardo, Vincenzo Stornelli, and Giorgio Leuzzi. "Class AB gyrator-based active inductor." In 2015 Integrated Nonlinear Microwave and Millimetre-wave Circuits Workshop (INMMiC). IEEE, 2015. http://dx.doi.org/10.1109/inmmic.2015.7330365.

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Barnabe-Lortie, Vincent, Colin Bellinger, and Nathalie Japkowicz. "Active Learning for One-Class Classification." In 2015 IEEE 14th International Conference on Machine Learning and Applications (ICMLA). IEEE, 2015. http://dx.doi.org/10.1109/icmla.2015.167.

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Ertekin, Seyda, Jian Huang, and C. Lee Giles. "Active learning for class imbalance problem." In the 30th annual international ACM SIGIR conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1277741.1277927.

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Schlachter, Patrick, and Bin Yang. "Active Learning for One-Class Classification Using Two One-Class Classifiers." In 2018 26th European Signal Processing Conference (EUSIPCO). IEEE, 2018. http://dx.doi.org/10.23919/eusipco.2018.8552958.

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Joshi, A. J., F. Porikli, and N. Papanikolopoulos. "Multi-class active learning for image classification." In 2009 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2009. http://dx.doi.org/10.1109/cvprw.2009.5206627.

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Jain, P., and A. Kapoor. "Active learning for large multi-class problems." In 2009 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2009. http://dx.doi.org/10.1109/cvprw.2009.5206651.

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Pantoli, L., V. Stornelli, and G. Leuzzi. "A wideband class-AB tunable active filter." In 2015 European Microwave Conference (EuMC 2015). IEEE, 2015. http://dx.doi.org/10.1109/eumc.2015.7346002.

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Pantoli, L., V. Stornelli, and G. Leuzzi. "A wideband class-AB tunable active filter." In 2015 10th European Microwave Integrated Circuits Conference (EuMIC). IEEE, 2015. http://dx.doi.org/10.1109/eumic.2015.7345159.

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Yankov, Dragomir, Suju Rajan, and Adwait Ratnaparkhi. "Integer Programming for Multi-class Active Learning." In 2010 IEEE International Conference on Data Mining Workshops (ICDMW). IEEE, 2010. http://dx.doi.org/10.1109/icdmw.2010.148.

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Reports on the topic "Active Class"

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Bhattacharjea, Suman, Sehar Saeed, Rajib Timalsina, and Syeed Ahamed. Citizen-led Assessments: A Model for Evidence-based Advocacy and Action to Improve Learning. Australian Council for Educational Research, June 2021. http://dx.doi.org/10.37517/978-1-74286-636-9.

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Designed as household-based assessments, citizen-led assessments (CLAs) are implemented by local organizations who assess children in their homes, thus reaching the most marginalized children, families, and communities, often in remote areas. CLAs add an essential piece of information for truly monitoring progress and help realistically represent the learning levels of all children – at national, regional, and global levels. By using simple tools and easy-to-understand reports, CLAs engage parents and community members in discussions about learning and help foster understanding of the importance of ensuring quality education through civil action. In this publication, members from organizations conducting CLAs in India, Pakistan, Nepal and Bangladesh provide an overview of the CLA model and illustrate a range of ways in which the model has been implemented in the four South Asian countries to monitor and improve learning. In all four countries, the initiative is known as the Annual Status of Education Report, or ASER – a word that means ‘impact’ in three of these four countries. By design, ASER assesses foundational reading and numeracy skills.
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Tucker-Blackmon, Angelicque. Engagement in Engineering Pathways “E-PATH” An Initiative to Retain Non-Traditional Students in Engineering Year Three Summative External Evaluation Report. Innovative Learning Center, LLC, July 2020. http://dx.doi.org/10.52012/tyob9090.

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The summative external evaluation report described the program's impact on faculty and students participating in recitation sessions and active teaching professional development sessions over two years. Student persistence and retention in engineering courses continue to be a challenge in undergraduate education, especially for students underrepresented in engineering disciplines. The program's goal was to use peer-facilitated instruction in core engineering courses known to have high attrition rates to retain underrepresented students, especially women, in engineering to diversify and broaden engineering participation. Knowledge generated around using peer-facilitated instruction at two-year colleges can improve underrepresented students' success and participation in engineering across a broad range of institutions. Students in the program participated in peer-facilitated recitation sessions linked to fundamental engineering courses, such as engineering analysis, statics, and dynamics. These courses have the highest failure rate among women and underrepresented minority students. As a mixed-methods evaluation study, student engagement was measured as students' comfort with asking questions, collaboration with peers, and applying mathematics concepts. SPSS was used to analyze pre-and post-surveys for statistical significance. Qualitative data were collected through classroom observations and focus group sessions with recitation leaders. Semi-structured interviews were conducted with faculty members and students to understand their experiences in the program. Findings revealed that women students had marginalization and intimidation perceptions primarily from courses with significantly more men than women. However, they shared numerous strategies that could support them towards success through the engineering pathway. Women and underrepresented students perceived that they did not have a network of peers and faculty as role models to identify within engineering disciplines. The recitation sessions had a positive social impact on Hispanic women. As opportunities to collaborate increased, Hispanic womens' social engagement was expected to increase. This social engagement level has already been predicted to increase women students' persistence and retention in engineering and result in them not leaving the engineering pathway. An analysis of quantitative survey data from students in the three engineering courses revealed a significant effect of race and ethnicity for comfort in asking questions in class, collaborating with peers outside the classroom, and applying mathematical concepts. Further examination of this effect for comfort with asking questions in class revealed that comfort asking questions was driven by one or two extreme post-test scores of Asian students. A follow-up ANOVA for this item revealed that Asian women reported feeling excluded in the classroom. However, it was difficult to determine whether these differences are stable given the small sample size for students identifying as Asian. Furthermore, gender differences were significant for comfort in communicating with professors and peers. Overall, women reported less comfort communicating with their professors than men. Results from student metrics will inform faculty professional development efforts to increase faculty support and maximize student engagement, persistence, and retention in engineering courses at community colleges. Summative results from this project could inform the national STEM community about recitation support to further improve undergraduate engineering learning and educational research.
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Lazonick, William, Philip Moss, and Joshua Weitz. The Unmaking of the Black Blue-Collar Middle Class. Institute for New Economic Thinking Working Paper Series, May 2021. http://dx.doi.org/10.36687/inetwp159.

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In the decade after the Civil Rights Act of 1964, African Americans made historic gains in accessing employment opportunities in racially integrated workplaces in U.S. business firms and government agencies. In the previous working papers in this series, we have shown that in the 1960s and 1970s, Blacks without college degrees were gaining access to the American middle class by moving into well-paid unionized jobs in capital-intensive mass production industries. At that time, major U.S. companies paid these blue-collar workers middle-class wages, offered stable employment, and provided employees with health and retirement benefits. Of particular importance to Blacks was the opening up to them of unionized semiskilled operative and skilled craft jobs, for which in a number of industries, and particularly those in the automobile and electronic manufacturing sectors, there was strong demand. In addition, by the end of the 1970s, buoyed by affirmative action and the growth of public-service employment, Blacks were experiencing upward mobility through employment in government agencies at local, state, and federal levels as well as in civil-society organizations, largely funded by government, to operate social and community development programs aimed at urban areas where Blacks lived. By the end of the 1970s, there was an emergent blue-collar Black middle class in the United States. Most of these workers had no more than high-school educations but had sufficient earnings and benefits to provide their families with economic security, including realistic expectations that their children would have the opportunity to move up the economic ladder to join the ranks of the college-educated white-collar middle class. That is what had happened for whites in the post-World War II decades, and given the momentum provided by the dominant position of the United States in global manufacturing and the nation’s equal employment opportunity legislation, there was every reason to believe that Blacks would experience intergenerational upward mobility along a similar education-and-employment career path. That did not happen. Overall, the 1980s and 1990s were decades of economic growth in the United States. For the emerging blue-collar Black middle class, however, the experience was of job loss, economic insecurity, and downward mobility. As the twentieth century ended and the twenty-first century began, moreover, it became apparent that this downward spiral was not confined to Blacks. Whites with only high-school educations also saw their blue-collar employment opportunities disappear, accompanied by lower wages, fewer benefits, and less security for those who continued to find employment in these jobs. The distress experienced by white Americans with the decline of the blue-collar middle class follows the downward trajectory that has adversely affected the socioeconomic positions of the much more vulnerable blue-collar Black middle class from the early 1980s. In this paper, we document when, how, and why the unmaking of the blue-collar Black middle class occurred and intergenerational upward mobility of Blacks to the college-educated middle class was stifled. We focus on blue-collar layoffs and manufacturing-plant closings in an important sector for Black employment, the automobile industry from the early 1980s. We then document the adverse impact on Blacks that has occurred in government-sector employment in a financialized economy in which the dominant ideology is that concentration of income among the richest households promotes productive investment, with government spending only impeding that objective. Reduction of taxes primarily on the wealthy and the corporate sector, the ascendancy of political and economic beliefs that celebrate the efficiency and dynamism of “free market” business enterprise, and the denigration of the idea that government can solve social problems all combined to shrink government budgets, diminish regulatory enforcement, and scuttle initiatives that previously provided greater opportunity for African Americans in the government and civil-society sectors.
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4

Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mutant receptors, cell lines and pheromone glands (at tissue and organism levels) against selected, designed compounds to confirm if compounds are agonists or antagonists. (2) The elucidation ofthemolecular regulationmechanisms of PBAN-R by:(a) age-dependence of gene expression; (b) the effect of hormones and; (c) PBAN-R characterization in male hair-pencil complexes. Background to the topic Insects have several closely related G protein-coupled receptors (GPCRs) belonging to the pyrokinin/PBAN family, one with the ligand pheromone biosynthesis activating neuropeptide or pyrokinin-2 and another with diapause hormone or pyrokinin-1 as a ligand. We were unable to identify the diapause hormone receptor from Helicoverpa zea despite considerable effort. A third, related receptor is activated by a product of the capa gene, periviscerokinins. The pyrokinin/PBAN family of GPCRs and their ligands has been identified in various insects, such as Drosophila, several moth species, mosquitoes, Triboliumcastaneum, Apis mellifera, Nasoniavitripennis, and Acyrthosiphon pisum. Physiological functions of pyrokinin peptides include muscle contraction, whereas PBAN regulates pheromone production in moths plus other functions indicating the pleiotropic nature of these ligands. Based on the alignment of annotated genomic sequences, the primary and secondary structures of the pyrokinin/PBAN family of receptors have similarity with the corresponding structures of the capa or periviscerokinin receptors of insects and the neuromedin U receptors found in vertebrates. Major conclusions, solutions, achievements Evolutionary trace analysisof receptor extracellular domains exhibited several class-specific amino acid residues, which could indicate putative domains for activation of these receptors by ligand recognition and binding. Through site-directed point mutations, the 3rd extracellular domain of PBAN-R was shown to be critical for ligand selection. We identified three receptors that belong to the PBAN family of GPCRs and a partial sequence for the periviscerokinin receptor from the European corn borer, Ostrinianubilalis. Functional expression studies confirmed that only the C-variant of the PBAN-R is active. We identified a non-peptide agonist that will activate the PBAN-receptor from H. zea. We determined that there is transcriptional control of the PBAN-R in two moth species during the development of the pupa to adult, and we demonstrated that this transcriptional regulation is independent of juvenile hormone biosynthesis. This transcriptional control also occurs in male hair-pencil gland complexes of both moth species indicating a regulatory role for PBAN in males. Ultimate confirmation for PBAN's function in the male tissue was revealed through knockdown of the PBAN-R using RNAi-mediated gene-silencing. Implications, both scientific and agricultural The identification of a non-peptide agonist can be exploited in the future for the design of additional compounds that will activate the receptor and to elucidate the binding properties of this receptor. The increase in expression levels of the PBAN-R transcript was delineated to occur at a critical period of 5 hours post-eclosion and its regulation can now be studied. The mysterious role of PBAN in the males was elucidated by using a combination of physiological, biochemical and molecular genetics techniques.
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5

Zarrieß, Benjamin, and Jens Claßen. Decidable Verification of Golog Programs over Non-Local Effect Actions. Technische Universität Dresden, 2015. http://dx.doi.org/10.25368/2022.224.

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The Golog action programming language is a powerful means to express high-level behaviours in terms of programs over actions defined in a Situation Calculus theory. In particular for physical systems, verifying that the program satisfies certain desired temporal properties is often crucial, but undecidable in general, the latter being due to the language’s high expressiveness in terms of first-order quantification and program constructs. So far, approaches to achieve decidability involved restrictions where action effects either had to be contextfree (i.e. not depend on the current state), local (i.e. only affect objects mentioned in the action’s parameters), or at least bounded (i.e. only affect a finite number of objects). In this paper, we present a new, more general class of action theories (called acyclic) that allows for context-sensitive, non-local, unbounded effects, i.e. actions that may affect an unbounded number of possibly unnamed objects in a state-dependent fashion. We contribute to the further exploration of the boundary between decidability and undecidability for Golog, showing that for acyclic theories in the two-variable fragment of first-order logic, verification of CTL properties of programs over ground actions is decidable
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6

Adegoke, Damilola, Natasha Chilambo, Adeoti Dipeolu, Ibrahim Machina, Ade Obafemi-Olopade, and Dolapo Yusuf. Public discourses and Engagement on Governance of Covid-19 in Ekiti State, Nigeria. African Leadership Center, King's College London, December 2021. http://dx.doi.org/10.47697/lab.202101.

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Numerous studies have emerged so far on Covid-19 (SARS-CoV-2) across different disciplines. There is virtually no facet of human experience and relationships that have not been studied. In Nigeria, these studies include knowledge and attitude, risk perception, public perception of Covid-19 management, e-learning, palliatives, precautionary behaviours etc.,, Studies have also been carried out on public framing of Covid-19 discourses in Nigeria; these have explored both offline and online messaging and issues from the perspectives of citizens towards government’s policy responses such as palliative distributions, social distancing and lockdown. The investigators of these thematic concerns deployed different methodological tools in their studies. These tools include policy evaluations, content analysis, sentiment analysis, discourse analysis, survey questionnaires, focus group discussions, in depth-interviews as well as machine learning., These studies nearly always focus on the national government policy response, with little or no focus on the constituent states. In many of the studies, the researchers work with newspaper articles for analysis of public opinions while others use social media generated contents such as tweets) as sources for analysis of sentiments and opinions. Although there are others who rely on the use of survey questionnaires and other tools outlined above; the limitations of these approaches necessitated the research plan adopted by this study. Most of the social media users in Nigeria are domiciled in cities and their demography comprises the middle class (socio-economic) who are more likely to be literate with access to internet technologies. Hence, the opinions of a majority of the population who are most likely rural dwellers with limited access to internet technologies are very often excluded. This is not in any way to disparage social media content analysis findings; because the opinions expressed by opinion leaders usually represent the larger subset of opinions prevalent in the society. Analysing public perception using questionnaires is also fraught with its challenges, as well as reliance on newspaper articles. A lot of the newspapers and news media organisations in Nigeria are politically hinged; some of them have active politicians and their associates as their proprietors. Getting unbiased opinions from these sources might be difficult. The news articles are also most likely to reflect and amplify official positions through press releases and interviews which usually privilege elite actors. These gaps motivated this collaboration between Ekiti State Government and the African Leadership Centre at King’s College London to embark on research that will primarily assess public perceptions of government leadership response to Covid-19 in Ekiti State. The timeframe of the study covers the first phase of the pandemic in Ekiti State (March/April to August 2020).
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7

Dawson, William O., and Moshe Bar-Joseph. Creating an Ally from an Adversary: Genetic Manipulation of Citrus Tristeza. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7586540.bard.

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Citrus is one of the major agricultural crops common to Israel and the United States, important in terms of nutrition, foreign exchange, and employment. The economy of both citrus industries have been chronically plagued by diseases caused by Citrus tristeza virus (CTV). The short term solution until virus-resistant plants can be used is the use of mild strain cross-protection. We are custom designing "ideal" protecting viruses to immunize trees against severe isolates of CTV by purposely inoculating existing endangered trees and new plantings to be propagated as infected (protected) citrus budwood. We crossed the substantial technological hurdles necessary to accomplish this task which included developing an infectious cDNA clone which allows in vitro manipulation of the virus and methods to then infect citrus plants. We created a series of hybrids between decline-inducing and mild CTV strains, tested them in protoplasts, and are amplifying them to inoculate citrus trees for evaluation and mapping of disease determinants. We also extended this developed technology to begin engineering transient expression vectors based on CTV as tools for genetic improvement of tree crops, in this case citrus. Because of the long periods between genetic transformation and the ultimate assay of mature tree characteristics, there is a great need for an effective system that allows the expression or suppression of target genes in fruiting plants. Virus-based vectors will greatly expedite progress in citrus genetic improvement. We characterized several components of the virus that provides necessary information for designing virus-based vectors. We characterized the requirements of the 3 ’-nontranslated replication promoter and two 3 ’-ORF subgenomic (sg) mRNA controller elements. We discovered a novel type of 5’-terminal sgRNAs and characterized the cis-acting control element that also functions as a strong promoter of a 3 ’-sgRNA. We showed that the p23 gene controls negative-stranded RNA synthesis and expression of 3 ’ genes. We identified which genes are required for infection of plants, which are host range determinants, and which are not needed for plant infection. We continued the characterization of native dRNA populations and showed the presence of five different classes including class III dRNAs that consists of infectious and self-replicating molecules and class V dRNAs that contain all of the 3 ’ ORFs, along with class IV dRNAs that retain non-contiguous internal sequences. We have constructed and tested in protoplasts a series of expression vectors that will be described in this proposal.
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8

Kellett, D. A., and A. Zagorevski. Overlap assemblages: Laberge Group of the Whitehorse Trough, northern Canadian Cordillera. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/326064.

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The Laberge Group was deposited during the Early to Middle Jurassic in a marginal marine environment, in the northern Canadian Cordillera. It occurs as a narrow, elongated siliciclastic unit along more than 600 km of strike length, overlapping the Intermontane terranes of southern Yukon and northwestern British Columbia. The Laberge Group was deposited on the Late Triassic Stuhini and Lewes River groups, a volcano-plutonic complex of the Stikine terrane (Stikinia), and, locally, the Kutcho Arc. It is overlain by Middle Jurassic to Cretaceous clastic units. The variations in clast composition and detrital zircon populations among these units indicate major changes in depositional environment, basin extent, and sources during the latest Triassic to Middle Jurassic. Detrital zircon populations are dominated by near contemporary Stuhini-Lewes River arc grains, consistent with dissection of an active arc. Detrital rutile and muscovite data show rapid cooling and exhumation of metamorphic rocks during the Early Jurassic. Thermochronological data indicate that basin thermal evolution was domainal, with at least five regional temperature-time histories.
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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, August 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist biophores (ii) to develop an arsenal of amphiphilic topically active PK/PBAN antagonists with an array of different time-release profiles based on the previously developed prototype analog; (iii) to develop rationally designed non-peptide SMLs based on the antagonist biophore determined in (i) and evaluate them in cloned receptor microplate binding assays and by pheromonotropic, melanotropic and pupariation in vivo assays. (iv) to clone PK/PBAN receptors (PK/PBAN-Rs) for further understanding of receptor-ligand interactions; (v) to develop microplate binding assays for screening the above SMLs. In the course of the granting period A series of amphiphilic PK/PBAN analogs based on a linear lead antagonist from the previous BARD grant was synthesized that incorporated a diverse array of hydrophobic groups (HR-Suc-A[dF]PRLa). Others were synthesized via the attachment of polyethylene glycol (PEG) polymers. A hydrophobic, biostablePK/PBAN/DH analog DH-2Abf-K prevented the onset of the protective state of diapause in H. zea pupae [EC50=7 pmol/larva] following injection into the preceding larval stage. It effectively induces the crop pest to commit a form of ‘ecological suicide’. Evaluation of a set of amphiphilic PK analogs with a diverse array of hydrophobic groups of the formula HR-Suc-FTPRLa led to the identification of analog T-63 (HR=Decyl) that increased the extent of diapause termination by a factor of 70% when applied topically to newly emerged pupae. Another biostablePK analog PK-Oic-1 featured anti-feedant and aphicidal properties that matched the potency of some commercial aphicides. Native PK showed no significant activity. The aphicidal effects were blocked by a new PEGylated PK antagonist analog PK-dF-PEG4, suggesting that the activity is mediated by a PK/PBAN receptor and therefore indicative of a novel and selective mode-of-action. Using a novel transPro mimetic motif (dihydroimidazole; ‘Jones’) developed in previous BARD-sponsored work, the first antagonist for the diapause hormone (DH), DH-Jo, was developed and shown to block over 50% of H. zea pupal diapause termination activity of native DH. This novel antagonist development strategy may be applicable to other invertebrate and vertebrate hormones that feature a transPro in the active core. The research identifies a critical component of the antagonist biophore for this PK/PBAN receptor subtype, i.e. a trans-oriented Pro. Additional work led to the molecular cloning and functional characterization of the DH receptor from H. zea, allowing for the discovery of three other DH antagonist analogs: Drosophila ETH, a β-AA analog, and a dF analog. The receptor experiments identified an agonist (DH-2Abf-dA) with a maximal response greater than native DH. ‘Deconvolution’ of a rationally-designed nonpeptide heterocyclic combinatorial library with a cyclic bis-guanidino (BG) scaffold led to discovery of several members that elicited activity in a pupariation acceleration assay, and one that also showed activity in an H. zea diapause termination assay, eliciting a maximal response of 90%. Molecular cloning and functional characterization of a CAP2b antidiuretic receptor from the kissing bug (R. prolixus) as well as the first CAP2b and PK receptors from a tick was also achieved. Notably, the PK/PBAN-like receptor from the cattle fever tick is unique among known PK/PBAN and CAP2b receptors in that it can interact with both ligand types, providing further evidence for an evolutionary relationship between these two NP families. In the course of the granting period we also managed to clone the PK/PBAN-R of H. peltigera, to express it and the S. littoralis-R Sf-9 cells and to evaluate their interaction with a variety of PK/PBAN ligands. In addition, three functional microplate assays in a HTS format have been developed: a cell-membrane competitive ligand binding assay; a Ca flux assay and a whole cell cAMP ELISA. The Ca flux assay has been used for receptor characterization due to its extremely high sensitivity. Computer homology studies were carried out to predict both receptor’s SAR and based on this analysis 8 mutants have been generated. The bioavailability of small linear antagonistic peptides has been evaluated and was found to be highly effective as sex pheromone biosynthesis inhibitors. The activity of 11 new amphiphilic analogs has also been evaluated. Unfortunately, due to a problem with the Heliothis moth colony we were unable to select those with pheromonotropic antagonistic activity and further check their bioavailability. Six peptides exhibited some melanotropic antagonistic activity but due to the low inhibitory effect the peptides were not further tested for bioavailability in S. littoralis larvae. Despite the fact that no new antagonistic peptides were discovered in the course of this granting period the results contribute to a better understanding of the interaction of the PK/PBAN family of Nps with their receptors, provided several HT assays for screening of libraries of various origin for presence of PK/PBAN-Ragonists and antagonists and provided important practical information for the further design of new, peptide-based insecticide prototypes aimed at the disruption of key neuroendocrine physiological functions in pest insects.
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10

Lers, Amnon, and Pamela J. Green. LX Senescence-Induced Ribonuclease in Tomato: Function and Regulation. United States Department of Agriculture, September 2003. http://dx.doi.org/10.32747/2003.7586455.bard.

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Natural leaf senescence, which occurs even when growth conditions are near optimal, has a negative influence on yield. Postharvest induced senescence contributes to the losses of quality in flowers, foliage, and vegetables. Strategies designed to control the senescence process in crop plants could therefore have great applied significance. However, the successful design of such strategies requires a better insight into the senescence machinery and control in higher plants. A main feature of senescence is the hydrolysis of macromolecules by hydrolases of various types such as ribonucleases (RNases) and proteases. Previously we had identified and characterized the tomato LX RNase gene demonstrating its transcript to be highly and specifically induced during senescence. This reported study was focused on LX but also had broadened our research to other senescence-associated nucleic acids degrading enzymes to learn about their function and the regulation of their encoding genes. Beside tomato we used parsley and Arabidopsis for the study of: the bi-functional nuclease which has a role in senescence. The study of different senescence- associated nucleases in few plant systems will allow a more general view on function and regulation of these enzymes in senescence. The specific original proposed objectives included: 1. Study the consequences of alterations in LX RNase level on tomato leaf senescence and general development; 2. Analyze stimuli which may participate in senescence-specific activation of the LX gene; 3. Clone the senescence-associated BFNI nuclease gene homologue from tomato. 4. Further characterize the sequences required for senescence-specific gene expression. Homozygous transgenic plants in which LX gene was either inhibited or over-expressed were generated. In both of these LX mutated plants no major phenotypic consequences were observed, which may suggests that LX is not essential for plant growth under optimal growth conditions. Lack of any abnormalities in the LX over-expressing lines suggests that special system exist to allow function of the RNase only when needed. Detailed analyses of growth under stress and consequences to RNA metabolism are underway. We have analyzed LX expression on the protein level demonstrating that it is involved also in petal senescing. Our results suggest that LX is responding to complex regulation involving developmental, organ dependent factors and responds differently to hormonal or environmental stimuli in the different plant organs. The cloned 1.4 kb promoter was cloned and its analysis revealed that probably not all required elements for senescence induction are included. Biochemical analysis of senescence-associated be-functional nucleases in the different plants, tomato, parsley and Arabidopsis, suggests they belong to a sub-class within the type I plant nucleases. The parsley PcNUC1/2 nuclease protein was purified from senescing leaves its and activity was studied in vitro revealing endo-, double strand, nucleolytic activity and exo-nucleolytic activity. Its encoding gene was cloned and found to be induced on the mRNA level. The promoter of the related Arabidopsis BFNI nuclease was shown in both tomato and Arabidopsis to be able and direct senescence-specific expression suggesting that, at least part, the gene is regulated on the transcriptional level and that the mechanism for this senescence-specific regulation is conserved between different plants. Few plants in which the BFNI gene is mutated were identified which are subjected now to detailed analysis. Our results suggest that the senescence-related nucleic acid degrading enzymes share similarities in both function and regulation between different plants and possibly have important functions in processes un-related to senescence. Still, the function of these enzymes, at least in some cases is not essential to plant development under optimal growth conditions. We are now at the stage which permits in depth investigation of the specific functions and mode of molecular regulation of senescence-associated nucleases with the aid of the research tools developed. The isolated senescence-specific promoter, shown to be active in heterologous plant system, could be utilized in agricultural-related biotechnological applications for retardation of senescence.
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