Dissertations / Theses: 'Activation of innovation activity'

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Воловик, Ю. Б. "Розробка інноваційної стратегії розвитку підприємств легкої промисловості." Thesis, Чернігів, 2020. http://ir.stu.cn.ua/123456789/20144.

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Воловик, Ю. Б. Розробка інноваційної стратегії розвитку підприємств легкої промисловості: магістерська робота : 072 Фінанси, банківська справа та страхування / Ю. Б. Воловик ; керівник роботи Ільчук В. П. ; Національний університет «Чернігівська політехніка», кафедра фінансів, банківської справи та страхування. – Чернігів, 2020. – 81 с.
Предметом дослідження ВКР є сукупність теоретичних, методологічних та методичних підходів до розробки інноваційної стратегії розвитку підприємств легкої промисловості з метою підвищення їх конкурентоспроможності в сучасних умовах господарювання. Об’єктом дослідження виступає розробка інноваційної стратегії на прикладі ПАТ “Берегиня ”. Мета кваліфікаційної роботи полягає в розробці інноваційної стратегії розвитку підприємств легкої промисловості. Завданнями роботи є розгляд теоретичних аспектів формування стратегії інноваційного розвитку, аналіз та оцінка інвестиційного забезпечення інноваційної діяльності підприємств легкої промисловості. Розглянуті питання активізації інноваційної діяльності на прикладі ПАТ “Берегиня”. За результатами дослідження сформульовані основні проблеми інноваційного розвитку в легкій промисловості та розроблені заходи щодо активізації інноваційної діяльності на прикладі ПАТ “Берегиня ”. Одержані результати можуть бути використані на практиці.

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Тищенко, Олександр Миколайович. "Формування системи Інтернет-комунікацій для активізації інноваційної діяльності підприємства (на прикладі ПАТ «Завод залізобетонних конструкцій ім. С. Ковальської»)." Master's thesis, Київ, 2018. https://ela.kpi.ua/handle/123456789/24980.

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Обсяг дисертації становить 114 сторінок. Основний текст дисертації містить 17 таблиць, 28 рисунків, 10 формул. Список використаних джерел налічує 55 найменувань та викладений на 7 сторінках. Актуальність теми дослідження зумовлена виявленням можливостей формування системи Інтернет-комунікацій, що дозволить підвищити інноваційну активність підприємства. Магістерська дисертація виконувалась відповідно до планів наукових досліджень кафедри менеджменту за темою НДР 0114U001132 «Інноваційні засади розвитку промислових підприємств в рамках інтеграції в світовий економічний простір». Метою роботи є формування системи Інтернет-комунікацій для вдосконалення інноваційної діяльності підприємства. Об'єктом дослідження є система Інтернет-комунікацій підприємства. Предметом дослідження є теоретичні та науково-методичні аспекти формування системи Інтернет-комунікацій для активізації інноваційної діяльнності ПАТ «ЗЗБК ім. Світлани Ковальської». Методи дослідження – у магістерській дисертації застосовувалися сукупність загальних і специфічних наукових методів. У процесі дослідження сучасних поглядів на систему Інтернет-комунікацій підприємства застосовувалися: системний підхід, методи економічного і статистичного аналізу, групування. Наукова новизна дослідження: • Удосконалено інноваційну діяльність ПАТ «ЗЗБК ім. Світлани Ковальської» в контексті виявлення можливостей формування системи Інтернет-комунікацій. Завдяки такому напрямку розвитку, використання Інтернет-комунікацій дає нові особливості і переваги порівняно з маркетингом, заснованому на традиційних технологіях. Дані технології дозволяють підвищити інноваційну активність підприємства, за рахунок комплексного використання всіх елементів запропонованої системи Інтернет-комунікацій підприємства. • Подальший розвиток отримала система Інтернет-комунікацій підприємства, зокрема корпоративний сайт компанії, який дозволить підприємству покращити свої економічні показники, підвищити інноваційну активність за рахунок вдосконалення на основі трьох головних компонентів: банерної реклами, сайту підприємства і інтернет-ресурсу «Веб-контроль бетону». Апробація результатів роботи. Основні положення дисертації доповідались та обговорювались на науково-методологічних семінарах кафедри менеджменту протягом 2017—2018 років, а також на всеукраїнських науково-практичних конференціях, зокрема: VІІІ—ІХ Всеукраїнських науково-практичних конференціях «Сучасні підходи до управління підприємством, (м. Київ, 2017—2018 рр.). Апробація результатів роботи. Основні положення дисертації доповідались та обговорювались на науково-методологічних семінарах кафедри менеджменту протягом 2017—2018 років, а також на всеукраїнських науково-практичних конференціях, зокрема: VІІІ—ІХ Всеукраїнських науково-практичних конференція «Сучасні підходи до управління підприємством», (м. Київ, 2017—2018 рр.), … Публікації. Теоретичні положення та практичні результати дослідження відображені в наступних виданнях: 1) Тищенко О. М. Вплив системи Інтернет-комунікації на активізацію інноваційної діяльності підприємства / О. В. Гук, О. М. Тищенко // Матеріали VІІІ Всеукраїнської науково-практичної конференції «Сучасні підходи до управління підприємством». — Київ, 6 квітня 2017 року. — К.: КПІ ім. Ігоря Сікорського.:URL: http://spu.fmm.kpi.ua/article/view/106870 2) Гук О. В. Інноваційні підходи до застосування Інтернет-комунікацій в маркетинговій діяльності підприємства / О. В. Гук, О. М. Тищенко // Науковий вісник Ужгородського національного університету Серія міжнародні економічні відносини та світове господарство, Випуск 17, частина 1, Ужгород 2018. – С. 87-89. 3) Тищенко О. М. Вплив системи Інтернет-комунікацій на активізацію інноваційної діяльності підприємства / О. М. Тищенко // Сучасні підходи до управління підприємством : Збірник праць учасників VІІІ Всеукраїнської науково-практичної конференції. — Київ, 06 квітня 2017 року. — С. 34.
The volume of the dissertation is 114 pages. The main text of the dissertation contains 17 tables, 28 figures, 10 formulas. The list of sources used includes 61 titles and is set out on 7 pages. Relevance of the topic of research is determined by the identification of the possibilities of forming the system of Internet communications, which will increase the innovative activity of the enterprise. The master's dissertation was carried out in accordance with the research plans of the Department of Management on the topic of research 0114U001132 "Innovative principles of development of industrial enterprises in the framework of integration into the world economic space". The purpose of the work is to create a system of Internet communications to improve the innovation activity of the enterprise. The object of research is the system of Internet communications of the enterprise. The subject of the research is theoretical and methodological aspects of the formation of the Internet communication system for activating the innovation activity of Plant «S. Kovalska RCP Plant». Methods of research - in the master's thesis applied a set of general and specific scientific methods. In the process of studying modern views on the system of Internet communications enterprises used: a systematic approach, methods of economic and statistical analysis, grouping. Scientific novelty of the research: 1. Improved innovation activity of Plant «S. Kovalska RCP Plant» in the context of identifying the possibilities of forming a system of Internet communications. Thanks to this direction of development, the use of Internet communications offers new features and benefits compared to traditional technology based marketing. These technologies allow to increase the innovative activity of the enterprise, due to the complex use of all elements of the proposed system of Internet communications of the enterprise 2. Further development was achieved by the system of Internet communications of the enterprise, in particular the corporate website of the company, which will allow the company to improve its economic performance, increase its innovative activity through improvement on the basis of three main components: banner advertising, site of the company and Internet resource "Web control of concrete » Approval of the results of work. The main provisions of the thesis were reported and discussed at the scientific and methodological seminars of the Department of Management during 2017-2018, as well as at all-Ukrainian scientific-practical conferences, in particular: VІІІ-IX all-Ukrainian scientific and practical conferences "Modern approaches to enterprise management (Kyiv, 2017-2018 gg.). Approval of the results of work. The main provisions of the thesis were reported and discussed at the scientific and methodological seminars of the Department of Management during 2017-2018, as well as at all-Ukrainian scientific and practical conferences, in particular: VІІІ-ІХ All-Ukrainian Scientific and Practical Conference "Modern Approaches to Enterprise Management" (Kyiv) , 2017-2018 gg.), ... Publications Theoretical positions and practical results of the research are reflected in the following editions: 1) Tуshchenko O. Influence of the Internet communication system on activization of innovative activity of the enterprise / O. Guk, O. Tyshchenko // Materials of the VIII All-Ukrainian Scientific and Practical Conference "Modern Approaches to Enterprise Management". - Kyiv, April 6, 2017. - K .: KPI them. Igor Sikorsky - Access mode: URL: http://spu.fmm.kpi.ua/article/view/106870 2) Guk O. Innovative approaches to the use of Internet communications in the marketing activities of the enterprise / O. Guk, O. Tуshchenko // Scientific Bulletin of Uzhhorod National University Series International Economic Relations and World Economy, Issue 17, part 1, Uzhgorod 2018. - P. 87-89. 3) Tуshchenko O. Influence of the Internet communication system on activization of innovative activity of the enterprise / О. Tуshchenko // Modern approaches to enterprise management: Collection of works of participants of the VIII All-Ukrainian Scientific and Practical Conference. - Kyiv, April 06, 2017. - P. 34.

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Малюта, Людмила Ярославівна, Людмила Ярославовна Малюта, and L. Y. Malyuta. "Економічний механізм активізації інноваційної діяльності підприємств сільськогосподарського машинобудування." Thesis, Тернопільський національний технічний університет ім. Івана Пулюя, 2011. http://elartu.tntu.edu.ua/handle/123456789/731.

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Дисертаційну роботу присвячено вирішенню проблеми розроблення теоретичних положень та прикладних рекомендацій щодо формування механізму активізації інноваційної діяльності підприємств сільськогосподарського машинобудування. У роботі висвітлено теоретико-методичні підходи до визначення сутності й значення інновацій в умовах розвитку конкурентного середовища. Проаналізовано сучасний стан і тенденції розвитку інноваційної діяльності підприємств сільськогосподарського машинобудування, визначено фактори впливу на її активізацію, доведено першочергову необхідність оновлення виробничого потенціалу та продукції. Удосконалено інструментарій щодо формування економічного механізму активізації інноваційної діяльності, розроблено алгоритм побудови інтеґрованої моделі активізації інноваційної діяльності в контексті ланцюга “держава–освіта і наука–підприємництво” та обґрунтовано необхідність удосконалення засобів інформаційного і маркетингового забезпечення в інноваційній інфраструктурі.
Диссертация посвящена вопросам разработки теоретических положений и практических рекомендаций по формированию механизма активизации инновационной деятельности предприятий сельскохозяйственного машиностроения. В первом разделе “Теоретические и практические аспекты активизации инновационной деятельности промышленных предприятий” раскрыто теоретико-методические подходы к определению сущности и значения инноваций в условиях развития конкурентной среды, углублено понимание терминов “инновация”, “инновационный процесс”, “инновационная деятельность”, “активизация инновационной деятельности”, показаны особенности моделирования, структуризации и организации инновационного процесса, осуществлена классификация факторов, влияющих на активизацию инновационной деятельности предприятий, исследован характер взаимосвязей инновационной политики государства и экономических механизмов содействия инновационной активности, а также развития новых инновационных структур. Во втором разделе “Характеристика состояния развития и активизации инновационной деятельности предприятий сельско¬хозяйственного машиностроения” проанализировано современное состояние и тенденции развития инновационной деятельности предприятий сельскохозяйственного машиностроения; определено, что инновационная активность не соответствует требованиям времени, поскольку большинство из них не проводят работ, направленных на освоение новой продукции и новых технологий. Выделены десять главных факторов, которые имеют решающее влияние на активизацию инновационной деятельности. Доказано первоочередную необходимость обновления продукции и производственного потенциала предприятий, обосновано внедрение современных подходов к организации подготовки производства. В третьем разделе “Формирование экономического механизма активизации инновационной деятельности предприятий сельскохозяйственного машиностроения” очерчены концептуальные основы государственной политики содействия инновационному развитию и внедрению комплексной инновационной стратегии, в которой выделены главные стратегические направления развития: освоение новых видов конкурентоспособной техники, усовершенствование структуры производства, развитие мощностей, развитие внутреннего и внешнего рынков и их инфраструктуры; усовершенствование нормативно-правового обеспечения. Для оптимального распределения средств по направлениям использована модель оптимизации процесса финансирования с учетом фактора времени; с помощью инструментария линейного программирования удалось найти такой неотъемлемый план распределения финансовых ресурсов, который удовлетворяет определенные ограничения и при этом функция цели (ожидаемая прибыль) получает максимальное значение. Разработан алгоритм построения интегрированной модели активизации инновационной деятельности отечественных предприятий в контексте цепи: “государство–наука и образование–предпринимательство”. Обоснована необходимость усовершенствования средств информационного и маркетингового обеспечения в инновационной инфраструктуре, создания территориальных отраслевых центров инновационного развития для активизации инновационных процессов и формирования благоприятной конкурентной среды.
The thesis is devoted to solving of the problem develop theoretical and applied recommendations dealing with the formation of mechanism of promotion of innovational activity of agricultural engineering enterprises. The work touches upon the theoretical and methodological approaches to determination of the nature and importance of innovations in competitive environment conditions. The current state and trends of the development of innovative activity of agricultural machinery enterprises, the factors of influence on its activation are analysed, the paramount need to upgrade the manufacturing capacity and production is shown. Methods for the formation of the economic mechanism of innovative activity promotion, the algorithm of building an integrated model of innovative activities promotion in the context of the chain: the state–science and education–business and the necessity of improving information and marketing support in the innovation infrastructure are developed. Key words: innovation, innovational process, activation of innovational activity, innovational infrastructure, economic mechanism, management.

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Абрютіна, Анастасія Вікторівна, Анастасия Викторовна Абрютина, and Anastasiia Viktorivna Abriutina. "Financial providing of enterprises' innovation activity." Thesis, Сумський державний університет, 2012. http://essuir.sumdu.edu.ua/handle/123456789/28678.

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Abryutina, A. V. "Financial management of firm's innovation activity." Thesis, Sumy State University, 2014. http://essuir.sumdu.edu.ua/handle/123456789/45226.

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In modern informational society and dynamic business environment innovation is the only factor which can sustain long-run growth of certain country under the influence of global development gap, rapidly changing customer needs, high level of market competition. Besides it not only governments but more and more firms are realizing the importance of innovation to gain competitive advantage. Obviously, they are engaging themselves in various innovative activities, ranging from manufacturing processes, product improvement, and brand building initiatives. Firms are creating new products, solutions and services that provide a radically better experience for the consumers.

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Herashchenko, Iryna. "Motivation and stimulation of innovation activity." Thesis, Національний технічний університет "Харківський політехнічний інститут", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/45714.

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Thomas, Dafydd Huw. "Regulation of Syk activity in GPVI-mediated platelet activation." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/92028.

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Pharmacology
Ph.D.
Activation of platelets is essential for hemostasis. Following damage to the vascular endothelium collagen is exposed, to which platelets stably adhere. After adhesion on collagen, a signaling cascade is initiated, mediated by Glycoprotein VI (GPVI), which results in platelet activation. A major signaling protein in GPVI signaling is Spleen tyrosine kinase (Syk). It undergoes phosphorylation and activation following GPVI stimulation. Syk's central role in this physiological process suggests regulation of its activity is required to maintain the platelets response to collagen within physiological limits. The regulation of Syk activation is the focus of this work. Previously published reports implicate the phosphatases SHP-1, SHP-2 and TULA-2 in the negative regulation of Syk. Therefore, we tested these phosphatases possible role in platelets. We show that SHP-1 can dephosphorylate Syk in vitro, but is unable to bind Syk. Also, Syk is hypophosphorylated in GPVI-stimulated SHP-1 deficient platelets and platelet functional responses are minimally affected compared to wild-type platelets. SHP-2 is unable to bind Syk and Syk is not a good substrate for SHP-2 in vitro. TULA-2 dephosphorylated Syk in vitro and associated with Syk in platelets. In TULA-2 deficient platelets, Syk and PLCγ2 were hyperphosphorylated compared to wild-type platelets. Deletion of TULA-2 resulted in enhanced GPVI-dependent platelet functional responses and a prothrombotic phenotype. c-Cbl has been shown to be a negative regulator of GPVI signaling, possibly by regulating Syk phosphorylation. Thus, SHP-1, SHP-2 and TULA-2’s role in c-Cbl regulation of GPVI was also investigated. We show that TULA-2 is able to bind c-Cbl in platelets. SHP-1 and SHP-2 do not. Furthermore, we show a striking similarity between the phenotype of TULA-2 and c-Cbl deficient platelets. However, in vitro binding studies show TULA-2 is able to bind Syk independently of c-Cbl. Thus, the exact role of c-Cbl in regulating Syk dephosphorylation is unclear. In conclusion, we show SHP-1 and SHP-2 are probably not involved in the negative regulation of Syk. However, TULA-2 is the major phosphatase responsible for the negative regulation of Syk in GPVI signaling. This serves to negatively regulate GPVI-mediated platelet function and prevent uncontrolled platelet activation that could lead to thrombosis.
Temple University--Theses

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Kuhakarn, Ravinda. "Open Innovation Activity for Product Development in SMEs." Thesis, KTH, Affärsutveckling och Entreprenörskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-97928.

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Open innovation opens up organizational boundaries so that a company can use and combine internal and external knowledge to develop and commercialize its own innovations, and can take its internal knowledge to market through external channels to generate additional value. There are many studies on large companies that use open innovation in order to develop their products, and keep up with rapid economic changes which affect their businesses. However there are not many studies on small- and medium-sized enterprises (SMEs) in terms of open innovation. SMEs are crucially important in global economy and innovation. They account for a large proportion in the global economy and create a large number of employment opportunities. They are more innovative than larger companies due to their flexibility and ability to quickly and efficiently integrate inventions created by their development activities. Nonetheless they lack of resources and appropriate structures. Accordingly innovation processes and strategies used for product development by large companies may not be appropriate for them. This study examines if SMEs should adopt open innovation activities for their product development and suggests that SMEs should adopt open innovation activities as complementary approaches to their internal R&D for their product development.

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Strauch, Kerry Elizabeth, and Ks_kes@ozemail com au. "Capturing innovation : entrepreneurial activity within an education organisation." RMIT University. Industry, Professional and Adult Training, 2005. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091028.095450.

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The 1990's in Victoria saw a political and economical shift away from the social justice themes of previous years to an economic rationalist approach to public sector services. Like other countries, educational reform initiatives focused on the introduction of market-oriented commercial practices. These were characterised by increased accountability for expenditure, pressure to supplement publicly funded income with commercial ventures, rationalisation of staff, privatisation of some services and a business-oriented approach to service provision. As part of this shift TAFE Institutes in Victoria were actively encouraged to embark on a business-based, entrepreneurial approach to training delivery in a competitive, user-choice market. This changing external environment is the context for this 'practitioner research' investigative project - the development of a motorsports program as a case study of innovation and entrepreneurship at Wodonga Institute of TAFE. A participant-observer research approach was applied to examine the perceptions of the stakeholders about the development of the program. Data was collected through semi-formal interviews with stakeholders, maintaining a reflective research journal and reviewing related literature. Analysis of the data identified emergent themes (enabling factors and barriers), reflecting at a micro level, similar themes and issues from current research and debate at national level. The themes are similarly reflected in literature on innovation, organisational change and entrepreneurship. The products generated from the investigative research project are:  Capturing Innovation: Entrepreneurial Activity Within a Publicly Funded Educational Organisation, an exegesis examining innovation and entrepreneurship at Wodonga Institute of TAFE through a case study (the motorsports program)  What a Great Idea! Where to From Here?, a set of guidelines for Wodonga Institute of TAFE practitioners about what is required in presenting their ideas to Senior Management (Appendix 1 and Appendix 2), and  a Professional development workshop agenda to support promotion of the guidelines (Appendix 2)  recommendations to Wodonga Institute of TAFE Directorate (Director/CEO and two Deputy Directors) for supporting the development of innovative ideas (Chapter 6). These outcomes aim to increase the success rate of innovative ideas being captured and developed into training programs and products at Wodonga Institute of TAFE.

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To, Chester Kin-man. "Modelling innovation activity processes for global fashion marketplaces." Thesis, De Montfort University, 2001. http://hdl.handle.net/2086/4254.

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Abryutina, A. V. "Optimization of financial providing of enterprises' innovation activity." Thesis, Sumy State University, 2014. http://essuir.sumdu.edu.ua/handle/123456789/45225.

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The recent financial instability in Ukraine and modern global tendencies in world economy have caused the necessity to find new financial recourses for innovation and investment activity of every competitive enterprise. Furthermore, the possibilities of self-financing and attraction of budgetary means, internal and external investments, banking credits, venture capital etc. are limited. This process is not only problematic, but expensive, risky and demanding highly experienced personnel. Besides it, every enterprise wants to receive maximum profit on the assumption of minimum costs. Thus the necessity to optimize the financial providing of enterprises’ innovation activity is obvious, and chosen direction of scientific research is topical enough.

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12

Pierrakis, Ioannis. "Investments and innovation : regional venture capital activity, business innovation and an ecology of interactions." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/23852/.

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This research adds to the growing literature from recent years on innovation finance, innovation systems, and regional economic and innovation policy. Although the role of business has been seen as critical within the regional innovation system, the role of business financing intermediaries has received considerably less attention despite its recognised role as a central actor of the system. This research focuses on an innovation player that seems to have been neglected by scholars to date, namely the venture capital industry. The research examines the role of different types of venture capital, public and private, in fostering innovation at the regional level. In examining this relationship, this thesis empirically analyses the characteristics of 4117 investments deals made to 2359 companies, the innovation outputs of these businesses and the responses to a survey of 50 venture capital professionals. The contribution of this thesis is threefold: First, this thesis investigates whether and how the supply of private sector venture capital and supportive public interventions has changed the availability of venture capital at the regional level. It examines the combination of venture capital in the UK regions by providing a detailed analysis of the extent of venture capital public dependency in each UK region. It also elaborates on the potential implications of the public sectors’s domination in venture capital provision in several UK regions. The regional dimension of the analysis is of special interest as it is the first comprehensive analysis of the source of VC investments (public or private) for each UK region. From a regional perspective, the UK now appears to have two venture capital markets. In London, the South East and, to a lesser extent, the East of England, private sector investors dominate investment activity. This contrasts with the remainder of the UK where the venture capital market is underpinned by extensive public sector involvement. Second, this thesis also investigates the role of venture capital in innovation using patents as a proxy variable for business innovation. In this way, it contributes to the literature by analysing the relation between patenting practices of venture capital backed firms, paying particular attention to two aspects: first, the company’s acquisition of venture finance and progress through the venture capital journey and second, the relationship between patent practices and source of venture capital finance (public or private) in UK regions. The analysis shows a clear relationship between venture capital and patents. Companies with patents are more likely to secure follow up venture capital finance compared with companies without patents. The econometric analysis results also suggest that UK companies with moderate public venture capital support are positively associated with patents while companies with extensive public venture capital support are negatively associated with patents, compared to companies with solely private venture capital support. The final part of the thesis investigates whether the environment in which funds operate may explain observed differences in the ability of these funds to invest in companies with the potential to innovate. It does this by examining the ecology of interaction between venture capital and regional innovation systems. This is the first detailed empirical investigation of the relationship between different types of venture capital (private or public) and other players of the innovation system such as universities incubators, research institutes, and regional authorities. Three important findings emerge from this analysis. First, venture capital public dependence is strongly and significantly associated with higher volumes of interactions with the outside world. The more publicly dependent a fund is, the more it interacts with other players of the innovation system. Second, the role of proximity is still important within the VC industry. Venture capitalists from both the private and the public sector, are more likely to interact with their counterparts from the same region. Third, there is evidence to suggest that operators of publicly backed funds are lacking close connections with their counterparts from the private sectors. This may have implications for their ability to approach and attract private heavy weighted venture capital funds and limited partners that can provide follow on investments or raise further funding for the fund. Although publicly backed venture capitalists interact to a greater extent than the private counterparts, they experience less success (measured as financial performance of the fund or performance of their portfolio companies). It is widely acknowledged that interactions between venture capitalists and other players promotes tacit knowledge, but the results of this thesis suggests that interaction on its own is not enough to provoke success. Overall, the findings of this research suggests that the distinction between the two venture capital markets in the UK, publicly or privately driven, is not limited to the volume or type of venture capital activity but also relates to the ecology of interactions between venture capitalists and other players of the regional innovation system. Since publicly backed funds do not promote innovation to the same extent that private funds do when they invest alone, UK regions that are heavily dependent on public investments may not be able to receive the benefits of a functional venture capital industry. However, regions in which public venture capital funds work closely with private funds, demonstrate a relatively higher volume of venture capital backed companies with the potential to innovate. From a policy perspective, this finding suggests that from an innovation point of view, free public standing investments should be minimised while co-investments between publicly backed and private venture capital funds should be further encouraged.

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Nilsen, Kristian Bernhard. "Autonomic activation and muscle activity in relation to musculoskeletal pain." Doctoral thesis, Norwegian University of Science and Technology, Department of Neuroscience, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1746.

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Background and objectives:

Musculoskeletal pain is frequent and the most common cause of sick leave in Norway. Although chronic musculoskeletal pain is conceived to be related to social or mental stress, the mechanism for such a relation is not known. The overall objective of the present thesis was to elucidate whether stress-associated musculoskeletal pain and stress-induced muscle activity may be related to activation of the autonomic nervous system.

Methods:

The present work is carried out in the laboratory where subjects performed a complex two-choice reaction time test designed to mimic mental load in a work place, resembling stressful and repetitive office work. Subjects were investigated while performing this stressful task for one hour, as well as during a baseline period immediately before and during a recovery period. We measured muscle activity and different parameters indicative of activity in the autonomic nervous system, as well as subjective variables as pain, tension and fatigue. We included patients with generalised (fibromyalgia) and patients with regionalised (shoulder/neck) musculoskeletal pain, as well as healthy controls. A group of patients with musculoskeletal pain were also subject to a block of peripheral sympathetic nerves with a unilaterally anaesthetic block of the lower cervical sympathetic ganglion before the stressful task.

Results:

We found the vascular response to the stressful task to be more protracted than other bodily responses (paper I). We found the muscular responses to the stressful task to be an unlikely explanation for the simultaneously developing pain response for all subjects, irrespective of diagnostic group (paper II). We found delayed pain recovery in both patients groups, but not in the healthy controls (paper II). We found an attenuated cardiovascular response to the stressful task in the fibromyalgia group compared to the healthy controls, with the shoulder/neck pain patients in an intermediate position (paper III). We also found an inverse relation between the heart rate response and the pain response for the fibromyalgia group (paper III). Lastly, we found that a block of peripheral sympathetic fibres did not affect neither pain nor muscle responses to the stressful task for patients with musculoskeletal pain.

Conclusions:

From the studies presented in the present thesis one may conclude that stress-associated musculoskeletal pain is probably not directly related to muscle activity or autonomic activation at a peripheral level. We found indications of central sensitisation of pain in both patient groups. In patients with generalised musculoskeletal pain (fibromyalgia), the pain may be related to a reduced physiological ability to respond adequately to stress.

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Sherstobitova, T. I. "An innovation as a result of joint creative activity." Thesis, ТОВ Друкарський дім "Папірус", 2012. http://essuir.sumdu.edu.ua/handle/123456789/29136.

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15

Fantino, Davide. "Innovation activity, R&D incentives, competition and market value." Thesis, London School of Economics and Political Science (University of London), 2010. http://etheses.lse.ac.uk/166/.

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This thesis examines some characteristics of the interaction between innovation activity of firms, in particular R&D, and economic system. The first main chapter analyses a mechanism of interaction between R&D and market structure, in a horizontally differentiated market where firms invest to increase differentiation among varieties. R&D activity declines over time; prices, output and short-run profits of firms producing the differentiated product move towards the higher steadystate values, production of the non-differentiated good falls. The increasing specialization improves the overall utility of consumers. The comparison with the socially optimal solution shows that firms underinvest in R&D. The second main chapter evaluates the effectiveness of the incentives to development of innovations provided by the Italian Ministry for Economic Development through the Fund for Technological Innovation. We analyse the subsidies to firms supplied by the general and the special sections of this Fund, using a difference-in-differences framework and a regression discontinuity one. We find no hints of effect on investments, dimension, labour productivity, labour costs, financial structure and profitability. For the general section, the effect on assets is positive, suggesting that firms used the subsidy to finance current expenditures. The third main chapter examines the relationship between R&D and market value of firms. We find high heterogeneity in the coefficients of different US manufacturing sectors between 1975 and 1995; sometimes the effects of current R&D on market value are very small or negative. We develop a model with uncertain R&D, where we decompose market value in two components, due to the already concretized assets and to work-in-progress R&D. Risk aversion may cause different evaluations of these components: when investors are risk-averse and managers maximize the long-run firm value, the risk associated with work-in-progress R&D reduces the short-run firm value even if its expected long-run value grows.

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Drev, Matej. "Essays on Firm Performance, Innovation, and Cross-Border Economic Activity." Research Showcase @ CMU, 2013. http://repository.cmu.edu/dissertations/321.

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This thesis is composed of three essays that explore different facets of firm performance, innovation, and cross-border economic activity. The first essay documents a systematic shift in the nature of innovation in information technology (IT) towards increasing dependence on software. Using a broad panel of US and Japanese publicly listed IT firms in the period 1983-2004, it shows this change in the nature of IT innovation had differential effects on the performance of the IT industries in the United States and Japan, resulting in US firms increasingly outperforming their Japanese counterparts, particularly in more software-intensive sectors. It also provides suggestive evidence that human resource constraints played a role in preventing Japanese firms from adapting to the documented shift in IT innovation. The second essay asks whether the United States have a comparative advantage in applications-related software research. It classifies software patents into downstream and upstream software inventions based on a unique classification algorithm, then offers empirical evidence that downstream software research is disproportionally concentrated in the United States, and that U.S. firms are significantly less likely to locate downstream software research projects offshore than upstream research projects. It also explores self-citation and co-invention patterns of software patents and provides suggestive evidence that U.S. firms may use intra-firm knowledge flows to mitigate challenges of conducting downstream software research remotely. Finally, it explores the sources for the observed U.S. advantage in downstream software research and provides initial empirical evidence supporting the hypothesis that it is at least partially due to the relative abundance of lead users of software within the United States. The final essay uses a rich panel dataset of Slovenian firms in the period 1994-2010 to examine how receiving foreign investment impacts the subsequent performance and behavior of local firms. Using a variety of propensity score based estimation techniques, it shows that foreign investment leads recipient firms to subsequently significantly expand the scale and scope of their activities. In addition, the essay explores how heterogeneity in investor origin modulates the effects of foreign investment, and it shows that investor origin heterogeneity is indeed important for understanding local firms’ ex post performance, the scale of their operations, the scope of their product mix and their geographical presence in export markets. It finds, for instance, that firms receiving investment from advanced country investors subsequently broaden the scope of their product mix and the number of export destinations they serve, while those receiving investment from developing country investors decrease their scope in terms of product space and geographical coverage. The empirical analysis is motivated with a theoretical model in which local firms endogenously chose their product mix and export destinations. The model details how receiving foreign investment affects the way firms alter their ex-post behavior, and then shows that predictions of the model align closely with the empirical results. The findings in this essay suggest that incorporating investor heterogeneity and the multi-product and multi-destination nature of firms yields important insights for furthering our understanding of how foreign investment impacts recipient firms.

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Pererva, P. G. "Balanced scorecard in the system of monitoring of innovation activity." Thesis, Кременчуцький національний університет імені Михайла Остроградського, 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/26286.

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18

Lambert, Jeffrey David. "Improving interventions for physical activity and depression." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/32585.

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Background: There is increasing evidence supporting the potential use of physical activity as an intervention for depression. However, effective behavioural interventions which focus on encouraging physical activity in people with depression are needed. Aim: This thesis reports on the development and pilot evaluation of a web-based intervention based on behavioural activation (BA) and physical activity promotion for people with depression (eMotion). There is also a specific focus on intervention fidelity. Method: A systematic review was conducted to identify how fidelity is assessed in behavioural interventions promoting physical activity in adults. Findings from the systematic review and the Centre for eHealth and Disease Management (CeHReS) Roadmap informed the development of eMotion. A novel “design fidelity” methodology was devised, which involved using an independent coder to systematically verify the presence or absence of intended and non-intended behaviour change techniques (BCTs). A pilot RCT of eMotion was conducted to provide evidence on the feasibility and acceptability of eMotion, and exploratory data on outcomes. A mixed methods process evaluation of the understanding, feasibility and enactment of the main BCTs used in eMotion, and participant’s perceptions of eMotion was conducted. Results: The systematic review presents a critical appraisal of the wide range of methods and measures used to assess intervention fidelity. The eMotion intervention consisted of weekly modules designed to re-engage people in routine, pleasurable, necessary or physical activities. Design fidelity of the intervention was excellent with discrepancies between intervention materials and the intended design for 12 out of 221 (AC1 =0.91) and 14 out of 221 (AC1 = 0.88) BCTs relating to BA and physical activity respectively. In the pilot trial, 62 people (≥10 on the PHQ-8) were randomised, and the two-month attrition rate was 19% (95% CI: 11 to 30%). Study completers in the eMotion group (n=25) had a significantly larger reduction in depressive symptoms than the waiting list control group (n=25) (Adj Mean Diff -3.6, 95% CI: -6.1 to -1.1). Participants using eMotion also reported significantly higher levels of understanding, ability and enactment of most BCTs compared with controls. Interviews with participants revealed a number of possible mechanisms by which eMotion may have changed behaviour (e.g. increased awareness of the link between mood and activity) and reduced depression (e.g. through distraction). Conclusion: This thesis has reported on the development and pilot evaluation of a behavioural intervention promoting physical activity for depression while focussing on fidelity. Further insight into a number of methodological and clinical implications for the conduct of future RCTs in this area has also been provided.

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19

Kong, Yazhuo. "Identification and modelling of haemodynamic response to neural activity during brain activation." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422130.

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20

Navarro-Fernandez, Oscar. "Synthesis, Activation and Catalytic Activity of N-Heterocyclic Carbene Bearing Palladium Catalysts." ScholarWorks@UNO, 2006. http://scholarworks.uno.edu/td/330.

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The syntheses and characterization of a series of (NHC)Pd(II) complexes (NHC = N-heterocyclic carbene) are described. A variety of architectures and precursors have been employed to lead to numerous air- and moisture-stable complexes. The use of those complexes as pre-catalysts in cross-coupling (Suzuki- Miyaura, Buchwald-Hartwig) and related (catalytic dehalogenation, £-ketone arylation) reactions is also discussed. A comparison of the activity of a variety of (NHC)Pd complexes as pre-catalysts for cross-coupling reactions was carried out. The results indicate that the activation of those pre-catalysts, leading to the catalytically active [(NHC)Pd(0)] species, was key in assuring high catalytic performance under mild reaction conditions. For the first series of complexes described, (NHC)Pd(allyl)Cl complexes, a better understanding of the process leading to the catalytically active species has permitted us to introduce simple modifications (alkyl or aryl groups at the allyl moiety) that dramatically alter the performance of the complexes by facilitating their activation, decreasing reaction times, catalyst loadings and even allowing reactions to be conducted at room temperature. Catalyst loadings as low as 0.05 mol% can be used for the Suzuki-Miyaura crosscoupling of aryl chlorides and aryl boronic acids at room temperature, leading to the synthesis of poly-ortho-substituted biaryls in excellent yields. This catalyst loading is the lowest ever used for this purpose. The system also allows for the first examples of coupling between aryl chlorides and alkenyl boronic acids at room temperature. When the temperature is raised to 80 ¢ XC for these reactions, a catalyst loading as low as 50 ppm can be used to effectively carry out Suzuki-Miyaura cross-couplings in remarkably short reaction times. As an added advantage, these complexes are air- and moisture-stable and can be prepared in a facile one-pot, multigram scale synthesis from commercially available starting materials in very high yields. The second series of complexes described revolves around the (NHC)Pd(acac)n framework. These complexes are also air- and moisture-stable and can be prepared in a one-step synthesis in high yields from commercially available materials. These complexes were tested forƒn £-ketone arylation and Buchwald-Hartwig amination reactions affording high yields of the desired products, in short reaction times and mild reaction conditions.

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21

Al-Kazemi, Saad A. "Patenting Activity, Firm Innovation Characteristics, and Financial Performance: An Empirical Investigation." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1249013130.

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Thesis (Ph.D.)--Case Western Reserve University, 2009
Title from PDF (viewed on 19 August 2009) Department of Accounting Includes abstract Includes bibliographical references Available online via the OhioLINK ETD Center

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Nagy, Szabolcs, and P. G. Pererva. "Monitoring of innovation and investment potential of industrial enterprises." Thesis, Харківський національний автомобільно-дорожній університет, 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/36517.

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23

Eichler, Anja. "Investigations of self-sufficient P450cam monooxygenases for activity and enantioselectivity." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/investigations-of-selfsufficient-p450cam-monooxygenases-for-activity-and-enantioselectivity(27df0fa8-b671-4593-8ec0-f993a31e120c).html.

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Catalytic, selective C-H bond activation for the oxidative hydroxylation RH → ROH of simple or complex compounds is of significant interest in synthetic organic chemistry. One of the major classes of enzymes used for C-H bond activation are cytochrome P450 monooxygenases (EC 1.14.X.X), which can promote chemo-, regio- and stereoselective oxidations under mild reaction conditions. For the current study, catalytically self-sufficient forms of biocatalyst P450cam-RhFRed were investigated. These self-sufficient P450 systems were previously created by fusing the reductase domain of P450 RhF (CYP116B2, RhFRed from Rhodococcus sp.) with the catalytic domain of P450cam (CYP101A1, Pseudomonas putida), thus mimicking the natural fusion of P450 RhF. The generation of 93 P450cam-RhFRed variants has expanded the synthetic toolbox to serve as a basis for exploring the substrate scope towards ethylbenzenes, substituted alkylbenzenes, 4-ethylphenol and (+)-pleuromutilin. To select for active mutants from this library of 93, high throughput screening methods were developed. A pooling approach was applied in order to express P450s and analyse them against a panel of non-natural substrates, such as ethylbenzene, 4-ethylphenol and (+)-pleuromutilin in whole cell biotransformation reactions. The concentration of P450 enzymes was determined using CO difference spectroscopy in whole cells. The assay was significantly improved both in terms of speed and safety by using carbon monoxide releasing molecules as a source of CO rather than the gas CO itself. These screening studies served as starting point to identify P450cam-RhFRed mutants for specific reactions. In particular, a systematic investigation of this library showed mutants that generated chiral benzyl alcohols with good enantioselectivities. To interpret these results on a structural basis, molecular dynamics simulations were used to estimate enantioselectivity of selected mutants for the regio-isomers of methylated ethylbenzene derivatives. The results from the molecular dynamics simulations were broadly consistent with experimentally determined data and identified the importance of conformational changes and flexibility of mutant-substrate complexes to enforce enantioselectivity.

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Powell, Ashley Ann. "Bile acid biological activity in colon cancer cells: From hydrophobicity to gene activation." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280045.

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Bile acids, known for millennia to play a role in health and disease, are currently being studied for their pivotal contribution to the development and possible prevention of colon cancer. Some bile acids have long been suspected to play a role in the development of colon cancer. Particularly, highly hydrophobic bile acids, such as deoxycholic acid (DCA), are known to promote the formation of colon tumors in animal models. However, one moderately hydrophobic bile acid, ursodeoxycholic acid (UDCA), has been shown to be a colon cancer chemopreventive agent, although its mechanism of action is unknown. Originally, it was believed that increased hydrophobicity caused high levels of cell membrane perturbation and digestion, thus resulting in cell death. In addition, it was believed that bile acids could cross membranes to a level related to their hydrophobicity and interact with intracellular molecules to induce biological responses. My studies have shown that while bile acid biological activity is related to hydrophobicity, bile acids do not have the innate ability to cross colon cell membranes. While highly hydrophobic bile acids cause a rapid induction of apoptosis and moderately hydrophobic bile acids cause growth arrest in colon cells, no evidence could be found to show that bile acids could enter colon cells. In fact, my data indicate that bile acids activate signaling cascades through transmembrane receptors on the plasma membrane. It is the activation of these signaling pathways, which result in DCA-induced apoptosis or UDCA-induced growth arrest. My studies have shown that DCA has the ability to activate GADDI53, FADD, and caspase 8 and that activation of these molecules is necessary to produce apoptosis. Additionally, I discovered that UDCA activates Rb and GADD153 and has the ability to induce GI growth arrest and protect cells from DCA induced apoptosis. Interestingly, I found that while DCA and UDCA cause drastically different cellular responses, my data suggest that they signal through shared pathways. I show that UDCA could abrogate DCA activity. These studies also show two possible by which UDCA acts as a chemo-preventive agent: by causing growth arrest and by preventing DCA-induced apoptosis.

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Мирошниченко, Юлія Олександрівна, Юлия Александровна Мирошниченко, Yuliia Oleksandrivna Myroshnychenko, Юлiя Тагiбекiвна Матвєєва, Юлия Тагибековна Матвеева, and Yuliia Tahibekivna Matvieieva. "Innovation activity as a factor of ensuring the economic security in Ukraine." Thesis, Le Mans University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/66813.

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The problem of ensuring the economic security of the country occupies the significant place in the macroeconomic policy of the developed countries of the world. To date, the level of economic security of the country depends on the innovation, activation of innovative activities and modernization in the innovation field. That is why special attention should be paid to the issues related to the research of the country’s innovation activity as one of the main factors of ensuring the economic security in Ukraine.
This work was supported by the Ministry of Education and Science of Ukraine (Project No. 0117U003922 «Innovative drivers of national economic security: structural modeling and forecasting»). Ця робота була підтримана Міністерством освіти і науки України (Проект № 0117U003922 «Інноваційні дравери національної економічної безпеки: структурне моделювання та прогнозування»).

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Zhou, Yan. "Regulation of Aurora A activity during checkpoint recovery." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181746.

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Cell division requires accurate DNA replication and cells develop checkpoint mechanisms toensure the correct passage of the genetic material. Cells arrest by a checkpoint when DNAdamage is found. After the checkpoint is silenced, the cell cycle can be resumed. Polo-likekinase 1 (Plk1) and Aurora A kinase (AurA) are both important regulators for checkpointrecovery. The question how AurA is activated was studied by many researchers, but the exactmechanism stays unclear.We developed a new setup to study AurA activation during checkpoint recovery. Quantitativeimmunofluorescence of fixed cells as well as a FRET probe that monitors Plk1 activity intime-lapse filming were applied in this study as indirect readouts of Aurora A activation. Theresult suggests that a Plk1-AurA feedback loop exists during checkpoint recovery. It can alsobe concluded that the inhibition of Cdk1 reduces Plk1 and AurA activity during checkpointrecovery. We also investigated the effect of calcium interfering drugs on AurA activation butno conclusive result was obtained.

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27

Sharif, Rubina Qasour. "Macrophage activating factor (MAF) in rainbow trout (Oncorhynchus mykiss) : biological activity and molecular source." Thesis, University of Stirling, 2003. http://hdl.handle.net/1893/26687.

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This study investigated the biological activity of a macrophage activating factor (MAF) produced by activated lymphocytes from the rainbow trout (Oncorhynchus mykiss) and attempts to discover its molecular source. Peripheral blood lymphocytes were shown to release factors with MAF activity following incubation with a variety of stimulants and were subsequently shown to activate macrophages using at least two different methods, the nitroblue tetrazolium (NBT) colourimetric assay and the luminol-dependent chemiluminescent assay. The latter technique detected an immediate response which decayed over a 40 minute period on the addition of cell-free supernatants from activated lymphocytes to macrophages. A number of molecular approaches, including degenerate PCR primer amplification, DNA cross-hybridisation and cDNA library screening were used in this study to try to isolate any cytokine genes from Oncorhynchus mykiss. As a control β-actin cDNA was successfully amplified from Oncorhynchus mykiss using primers based on the salmon sequence. The Oncorhynchus mykiss orthologue of IFN-y was initially targeted. However, although a PCR product of the appropriate size was amplified using degenerate primers based on mammalian and avian IFN-y sequences, the sequence was not related to IFN-y or any other known Oncorhynchus mykiss sequence. A similar strategy was used to try and amplify the Oncorhynchus mykiss orthologue of mammalian IL-15. Again despite amplification of a DNA fragment of approximately the correct size there appeared to be no relationship between it and the known IL-15 sequences. As an alternative strategy a cDNA library from stimulated peripheral blood lymphocytes (PBLs) was constructed and screened using cDNA probes derived from stimulated and non-stimulated PBLs in order to detect mRNAs which might have been upregulated as a result of in vitro stimulation. A number of positive clones were obtained from the differential screening of the library including cDNAs showing similarity to other unidentified fish sequences as well as to a number of proteins predicted to be involved in regulation of cell proliferation, neocorticogenesis and embryo development. Additionally. the library was also screened using ovine cytokine cDNA probes. although no positively hybridising clones were obtained. The ovine IFN-y gene was also used to probe genomic DNA from Oncorhynchus mykiss. but unlike previous studies with human IFN-y gene no hybridisation between the ovine IFN-y gene and Oncorhynchus mykiss DNA was observed. This investigation highlights the potential difficulties of using various molecular strategies such as DNA cross-hybridisation or PCR techniques for the cloning of fish cytokine sequences. Consequently, future strategies for cloning fish cytokine genes may require targeting the biological activity through expression libraries.

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Fredriksson, Cecilia, and Christina Ramberg. "Palaestra : Outdoor activity for seniors." Thesis, Karlstads universitet, Fakulteten för teknik- och naturvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-7929.

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The assignment from Slottsbro AB was to construct an outdoor activity in modular form, without electronics, mechanics or weights as resistance, targeting seniors. To gain better understanding of what kind of activities seniors need and what problem areas they have, interviews were made with physiotherapists’, researchers and training instructors. Seniors were interviewed and answered questionnaires and observations of various kinds were made to gain further knowledge and inspiration. A literature study was made to gain knowledge of seniors’ health and physiology, fitness and movement exercises and fall prevention. Exercise is a great way for preventing falls, especially functional training, meaning training to manage everyday life. It is particularly balance, leg strength, explosive arm strength and mobility that need to be trained. During the construction phase sketches of various suggestions on equipment or motion exercises were made and were consulted with Slottsbro AB. CAD-models were constructed based on the previous decisions. From these CAD-models prototypes at scale of 1:10 were made in the University workshop. The models were later used to take product pictures outdoors, in order to give an idea of how a full-scale design would look like. Scale models were also used in the compulsory thesis exhibition. To show how the park should be used a stop film was made. It was meant as an illustrative element during the exhibition and final presentation. The modules that were developed were:  A bench with three different seat heights  A balance board  A staircase combined with an inclined plane  Bars in different heights to stand by and do different types of exercises,  Rings attach to rubber bands with different resistance  Windlass, curved pipe and spinning wheels The activity park was named Palaestra which means “training” in Latin.
Projektet från Slottsbro AB gick ut på att konstruera en utomhusaktivitet i modulform utan elektronik, mekanik eller tyngder som motstånd som riktar sig till seniorer. För att få ökad förståelse gällande vad seniorer behöver för aktiviteter och vilka problemområden som finns gjordes intervjuer med sjukgymnaster, forskare och träningsinstruktörer. Seniorer intervjuades samt svarade på enkäter och observationer av olika slag gjordes för att få ytterligare kunskap och inspiration. En litteraturstudie gjordes kring äldres hälsa och fysiologi, träning och rörelseövningar samt fallprevention. Träning är ett bra sätt att förebygga fallolyckor på, och då speciellt funktionell träning, med andra ord träning för att klara vardagen. Det är framförallt balans, benstyrka, explosiv armstyrka och rörlighet som behöver tränas. Under konstruktionsarbetet skissades olika förslag på utrustning eller rörelseövningar upp och konsulterades med uppdragsgivaren. CAD-modeller gjordes på de delar som valts att jobba vidare med. Utifrån dessa togs prototyper i skala 1:10 fram i universitetets verkstad. Modellerna användes senare för att ta produktbilder utomhus, detta för att ge en bild av hur en fullskalig konstruktion skulle se ut. Skalmodellen användes även i den obligatoriska exjobbsutställningen. För att visa hur parken skall användas gjordes en stop motion film. Den användes som ett illustrativt inslag under redovisning och utställning. De moduler som togs fram var:  En bänk med tre olika sitthöjder  En balansbräda  En trappa kombinerad med ett lutande plan  Barrar i olika höjd att stå vid och utföra olika typer av övningar  Ringar fästa i gummiband med olika motstånd  Vindspel, krullrör samt snurrhjul Aktivitetsparken döptes till Palaestra som på latin betyder träning.

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Смоленніков, Денис Олегович, Денис Олегович Смоленников, Denys Olehovych Smolennikov, Людмила Сергіївна Захаркіна, Людмила Сергеевна Захаркина, Liudmyla Serhiivna Zakharkina, Юлія Олександрівна Мирошниченко, et al. "Efficiency of innovation activity funding as the driver of the state's national economic security (case of Ukraine)." Thesis, Economic Laboratory for Transition Research, 2018. http://essuir.sumdu.edu.ua/handle/123456789/67683.

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The issue of economic security does not cease to be one of the priorities in forming macroeconomic policy of developing countries. This issue is particularly topical in the context of current challenges at the regional, European and global levels. One of the effective ways to increase economic security can be the innovative vector of economic development and the maximum application of scientific and innovative potential in all sectors of national economy. The study is devoted to the analysis of impact of innovative activity of enterprises on the level of economic security in the context of sustainable socio-economic development of the country.

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Beyer, Hans [Verfasser]. "Activation of nitrogen oxides by supported noble metal catalysts: Structure-activity relationships / Hans Beyer." München : Verlag Dr. Hut, 2010. http://d-nb.info/1009095641/34.

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Luthfa, Karim Sabrina. "The Uncertainty-Embedded Innovation Process : A study of how uncertainty emerges in the innovation process and of how firms address that to create novelty." Doctoral thesis, Högskolan i Halmstad, Centrum för innovations-, entreprenörskaps- och lärandeforskning (CIEL), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-33850.

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Despite much discussion in the literature of uncertainties in relation to the innovation process, there is little knowledge of how they emerge in this process. This thesis accordingly aims to understand how uncertainty emerges in the innovation process and how firms address that uncertainty to create novelty from the process. Uncertainty is embedded in the innovation process (Jalonen, 2012), which implies that it is not only a factor affecting the innovation process but also an outcome of the process itself. To fulfil the purpose of this study, it is important to understand how the innovation process unfolds over time. It is well established that innovation is a process of recombining resources (Schumpeter, 1934) through the performing and linking of certain activities in sequence (Richardson, 1972; Dubois, 1994; Bankvall, 2011) by various actors (i.e., firms and organizations) in a network context (Håkansson and Olsen, 2012; Lampela, 2012; Love and Roper, 2001; Pittaway et al., 2004; Powell et al., 1996). To fulfil the purpose of this study, the following research question has been asked: How and why do actors undertake and link resource recombination activities in a network context, thereby managing uncertainties in the innovation process? The thesis investigates the innovation process in two companies. One of the companies had completed its innovation journey and the other had almost done so. The discussion gives a detailed account of: the activities these companies performed alone and jointly with their partners in a network context; the resources they exchanged with each other and recombined to bring new solutions to the market; the uncertainties created in the process of recombining the resources; and the activities they undertook in response to address these uncertainties. The innovation process in the case companies is analysed in light of a conceptual model developed here based on Dubois’ (1994) “end product related activity structure model”, Håkansson’s (1987) “ARA model/network model”, and Goldratt’s (1997) “critical chain concept”. This study identifies the conditions under which uncertainties emerged in the innovation process in the studied companies. One of the significant conditions was resource unavailability, which was caused by actors’ reluctance to share resources, prohibition by government policy, and the resources’ own conflicting conditions and internal resistance (Håkansson and Snehota, 1995; Håkansson and Waluszewski, 2002; Waluszewski, 2004). Resource unavailability caused inertial and repetitive activities and delayed the process of producing an outcome, having such an impact on the activities under the condition of path dependency (Arthur, 1994; David, 2000). Another observed condition was the actors’ lack of knowledge of resource combination (Jalonen, 2011). A type of uncertainty that seriously affects the outcome of the innovation process is the activity void, a situation in which no activity is taking place. Activity voids are created from resource unavailability either by an actor’s reluctance to share resources or by the outcome of combining conflicting resource properties. The outcome of the innovation process is therefore affected by the key actor’s attempt to reduce the activity void by making compromises at the three levels, interplay among which construct the process, i.e., actors, resources, and activities. To manage uncertainties, managers make many compromises when they perform and link various activities. Although the underlying motivation for making compromises is rational, it is boundedly rational (Simon, 1957) because by making compromises, managers forego expectations of having all the properties or of being able to plan, undertake, and link activities as intended. This study also reveals that sometimes actors prefer not to make compromises despite knowing that this might cost a great deal. Accordingly, the findings suggest that compromises made within a working relationship allow actors to produce novelty without deviating from the desired path by ensuring access to resources and partners’ abilities. On the contrary, compromises not made in the relationship can threaten actors’ ability to produce the desired novelty, as the exchange of partners’ resources and abilities is hindered in a poor relationship. Compromises made in resource configuration and activities threaten actors’ ability to produce the desired novelty by limiting their choices, while compromises not made in resource configuration and activities allow actors to produce the desired novelty without deviation.

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Lidén, Martin. "Molecular aspects of retinol uptake and activation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-556-9/.

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Scuicciarini, Mariagrazia. "Do science and technology parks encourage innovation? : evidence from the tenants' patenting activity." Thesis, University of Essex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413246.

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Farias, Fabriana Helena Geraldo. "11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissue." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4909.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on January 3, 2008) Includes bibliographical references.

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Cheng, Crystal. "Quinone reductase activity and the activation of mitomycin C cytotoxicity in the lens epithelial cells." Connect to resource, 2006. http://hdl.handle.net/1811/22004.

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Thesis (Honors)--Ohio State University, 2006.
Title from first page of PDF file. Document formatted into pages: contains v, 21 p.; also includes graphics. Includes bibliographical references (p. 18-21). Available online via Ohio State University's Knowledge Bank.

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Cullen, Stephen Ronald. "An investigation of the activity and activation of clayzic and clayfec as Friedel-Crafts catalysts." Thesis, University of York, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261090.

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Brown, Rachel Anne. "The effects of heparin and related molecules upon neutrophil activation and mediator activity in vitro." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407973.

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Зянько, В. В., and Сіньїн Дун. "Критерії оцінювання ефективності інноваційної діяльності підприємств." Thesis, ВНТУ, 2019. http://ir.lib.vntu.edu.ua//handle/123456789/24395.

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Проаналізовано основні критерії ефективності інноваційної діяльності підприємств, здійснено їх узагальнення та запропоновано систему показників, які забезпечують об’єктивну оцінку якості інноваційних проектів
There has been analyzed main criterions of the innovation activity efficiency of enterprises; carried out their generalization; a system of indicators that provide an objective assessment of the quality of innovative projects was provided

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Khan, Zareen A. "The role of integrins in the activation of fibroblasts from skin, lung and breast tissue." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25902.

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Fibroblasts are abundant mesenchymal cells present in all tissues in a quiescent state, which contribute to wound healing when activated. Cytokine transforming growth factor-β1 (TGF-β1) stimulates fibroblast-myofibroblast differentiation, which induces extracellular matrix secretion, tissue contraction and promotes cancer cell migration. Hence, chronic activity of stromal myofibroblasts correlates with a poor prognosis for cancer and organ fibrosis patients. Therefore, modulating myofibroblast activity may reduce the severity of these diseases. Previous research suggests blockade of transmembrane integrin receptors expressed by fibroblasts prevents TGF-β1- induced differentiation, indicating integrins are attractive therapeutic targets. However, fibroblasts derived from different organs exhibit heterogeneity, although their integrin expression and integrin-regulated differentiation has not been directly compared. The aim of my research was 1) to understand and compare how integrins regulate TGF-β1-induced activation of fibroblasts derived from normal skin, lung and breast tissue; 2) to examine the global gene expression of TGF-β1-treated lung fibroblasts; 3) to identify novel therapeutic targets that modulate TGF-β1-induced activation of lung fibroblasts using a drug library. qPCR showed skin, lung and breast fibroblasts differentially expressed TGF-β1- induced activation markers, including ACTA2, FN1, TIMP3, CTGF and SERPINE1, in addition to integrin genes for α1, α4, α11 and β3. Small-molecule inhibitors of αv integrins only reduced the invasion of TGF-β1-exposed skin fibroblasts, but not lung or breast fibroblasts. siRNA against α11, β3 and β5 decreased TGF-β1-induced collagen contraction and activation marker expression in skin and lung fibroblasts, while α1 siRNA prevented collagen contraction by breast fibroblasts only. RNA sequencing of TGF-β1-treated lung fibroblasts revealed pro-inflammatory and profibrotic pathways were significantly enriched, while screening TGF-β1-treated lung fibroblasts with a FDA-approved drug library identified 46 hits that significantly reduced α-smooth muscle actin and fibronectin expression. Overall, genes are differentially expressed in TGF-β1-treated skin, lung and breast fibroblasts, while different integrins in each fibroblast appear to regulate invasion, TGF-β1-induced collagen contraction and gene expression. RNA sequencing revealed TGF-β1 promotes the expression of a pro-tumour signature in lung fibroblasts and several novel therapeutic targets that modulate the activation of lung fibroblasts have been identified. Understanding these integrin-dependent and independent mechanisms will facilitate the generation of myofibroblast-targeted treatments for cancer and organ fibrosis.

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Bell, Catherine M. "RHEB DYNAMICS ON LYSOSOMAL MEMBRANES DETERMINES MTORC1 ACTIVITY AFTER LOSS OF P53 OR ACTIVATION OF AMPK." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4036.

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The tumor suppressor TP53 is the most frequently altered gene in human cancers. The growth-promoting complex, mTORC1 plays a part of the oncogenic profile caused by dysfunctional p53. mTORC1 sits downstream of AMPK and other crucial tumor suppressors/oncogenes, PTEN, LKB1, and Akt. The antifolate pemetrexed was found by this laboratory to activate AMPK via the inhibition of the enzyme AICART in de novo purine synthesis. This work presents a mechanism of mTORC1 activation with p53 loss, as well as of mTORC1 inhibition by pemetrexed-induced AMPK. We have found that mTORC1 activity was substantially upregulated by the loss or mutation of p53. This activation involves the loss of TSC2 from lysosomal membranes, the site of mTORC1 activation by Rheb. We demonstrate that loss of lysosomal TSC2 increased the levels of lysosomal Rheb. Control of mTORC1 was restored by overexpression of TSC2, which correlated with decreased lysosomal Rheb. Surprisingly, pemetrexed-activated AMPK did not phosphorylate TSC2 because of an accumulation of nonfunctional p53, and a subsequent decrease in TSC2 mRNA. Accordingly, lysosomal TSC2 decreased, however, the levels of lysosomal Rheb decreased. Future studies will question whether the robust Raptor phosphorylation by pemetrexed is involved in this decrease in lysosomal Rheb. AMPK activation by pemetrexed also significantly increased the translocation of AMPK to the nucleus, and we will explore the function of this nuclear AMPK. Overall, these findings present a mechanism involved in the oncogenic signaling of mTORC1 with loss of p53 and offer insight into how pemetrexed reinstates control.

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Smith, Andrew J. J. "Effects of Age on Knee Activation Characteristics during Weight Bearing and Directional Loading." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22718.

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We developed a novel approach that requires subjects to produce and finely tune ground reaction forces (GRFs) while standing. Using this method we were able to identify specific contributions of individual muscles and how these contributions change with the effects of age. One of the aims of this investigation was to determine whether electromyographic data in our findings was due to random muscle activation or representative of a neuromuscular control strategy. Ten healthy young adults (5 male, 5 female) with their dominant foot fixed within a boot mounted to a force platform participated twice in a target matching protocol, requiring subjects to control both the direction and magnitude of GRF along the horizontal plane while maintaining constant inferior-superior loads of 50% body-weight. Subjects were asked to manoeuvre a cursor with their dominant leg to match a series of targets projected on a screen. Targets appeared at random one at-a-time, separated by 30o around a circular trajectory. Subjects applied loads to the force platform in various horizontal directions to move the cursor while also controlling body weight. A successful target match required subjects to maintain 50% body weight and 30% of their peak horizontal load for one second. Electromyography (EMG) of eight muscles that cross the knee joint, ground reaction forces, and kinematic data were recorded for each successful match. EMG was normalized to percent maximum voluntary isometric contractions collected on an isokinetic dynamometer. Each target matching session was separated by two-three days. A random model, single measures intra-class correlation analysed the reliability for both test-retest and intra-day results, in addition to intersubject reliability. We observed moderate to high ICC values (0.60 – 0.993) for most muscles in most directions, indicating low within-subject variance. In addition, moderate to high between-subject reliability was observed in all eight muscle activation profiles, indicating subjects used similar neuromuscular control strategies to achieve the desired GRFs. Our findings support that groups who have undergone the same number of testing sessions can be compared, and that a single testing session is all that is required to compare neuromuscular control strategies used by a group to achieve target locations. The second aim of this investigation was to evaluate age related differences in neuromuscular control about the knee joint using our target match protocol. Thirty-three healthy adults (17 younger 24 years ±2, 16 older 59 years ±5), completed the same protocol evaluated above. The mean magnitude of muscle activity, specificity index, and mean direction of muscle activity were calculated in each target direction. Older adults presented with significantly lower strength in knee flexion and extension, hip abduction, and ankle plantar flexion. Significantly (p<0.25) higher mean activation magnitudes in the rectus femoris, vastus lateralis, vastus medialis, biceps femoris, semitendinosus, medial gastrocnemius, and tensor facia lata were also observed. Intraclass correlations (ICC) magnitudes indicate the percentage of global variance that can be explained by within subject and between trial variability. Muscle activation patterns were found to be similar in all muscles (ICC≤0.82). Similar patterns are supported by non-significant differences in mean direction of activation and muscle activation specificity. These results indicated that healthy older adults utilise different activation magnitudes for stabilising the knee while maintain similar muscle activation synergies in all muscles to younger adults.

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Karkehabadi, Saeid. "Structure-function studies of ribulose-1,5-bisphosphate carboxylase/oxygenase : activation, thermostability, and CO2/O2 specificity /." Uppsala : Dept. of Molecular Biology, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200528.pdf.

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Богуш, Андрій Олександрович. "Удосконалення системи інноваційного менеджменту у діяльності підприємства (на прикладі ТОВ "Делятинська деревообробна фабрика")." Master's thesis, ТНТУ імені Іванав Пулюя, 2018. http://elartu.tntu.edu.ua/handle/lib/24137.

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Метою магістерської роботи є визначення та удосконалення системи інноваційного менеджменту ТОВ “Делятинська деревообробна фабрика”, що дасть змогу провести реальне оцінювання управління інноваціями, виробничо-господарської, фінансової, кадрової діяльності деревообробного підприємства, а також розроблення теоретичних положень та практичних рекомендацій щодо покращення системи управління інноваційного менеджменту у діяльності підприємства. Об’єкт дослідження – сукупність виробничих, фінансово-економічних управлінських відносин, що формуються у процесі функціонування ТОВ “Делятинська деревообробна фабрика”, яке знаходиться у смт. Делятин, Надвірнянського р-ну, Івано-Франківської обл. Предметом дослідження є визначення та удосконалення системи інноваційного менеджменту у діяльності ТОВ “Делятинська деревообробна фабрика”, а також теоретичні, правові та практичні засади виробничої, фінансово-господарської та інноваційної діяльності деревообробного підприємства. Структура магістерської роботи. Робота складається з вступу, п’яти розділів, висновків, списку використаної літератури та додатків.
The aim of the master’s thesis is to identify and improve the system of innovative management of LTD “Delyatynka woodworking factory”, which will enable real assessment of management of innovations, production, economic, financial, personnel activities of the woodworking enterprise, as well as the development of theoretical provisions and practical recommendations for improving the management system of innovation management in the activity of the enterprise. The object of investigation is the totality of production, financial and economic management relations that are formed during the operation of LTD “Delyatynka woodworking factory”, which is located in the village Delyatyn, Nadvirna district, Ivano-Frankivsk region. The aim of the work is to identify and improve the system of innovative management in the activity of LTD “Delyatyansky woodworking factory”, as well as the theoretical, legal and practical principles of the production, financial, economic and innovation activity of the wood-processing enterprise. The structure of the master’s work. The work consists of an introduction, five sections, conclusions, list of used literature and applications.

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Neagu, Dan. "Does Heightened M&A Activity Benefit Innovation and Consumers? Evidence from the Pharmaceuticals Industry." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104216.

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Thesis advisor: Michael D. Grubb
The aim of this paper is two-fold: 1) to explore the ex-ante relatedness of merging pharmaceutical companies and 2) to study the ex-post effects of mergers on R&D innovation and drug prices, where innovation is quantified by the number of patents granted. Annual firm-specific financial and patent data in this study were obtained for years between 1987 and 2014, while quarterly drug price data spanned from 2006 Q1 to 2015 Q1. The empirical results suggest that on average, heightened M&A activity leads to diminished R&D output and higher drug prices. These results are confirmed using time series models and by comparing post-merger performance of merged firms to that of their respective control groups through a propensity score matching method
Thesis (BS) — Boston College, 2015
Submitted to: Boston College. Carroll School of Management
Discipline: Departmental Honors
Discipline: Economics

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Duchane, Christine Marie. "Synthesis, antimicrobial activity, and catalytic activity of rhodium and iridium piano stool complexes: Teaching an old dog new tricks." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/101016.

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This dissertation describes the synthesis, antimicrobial properties, and catalytic activity of a variety of eta5-ligand rhodium and iridium complexes. Cp*RM(beta-diketonato)Cl (Cp*R = R-substituted tetramethylcyclopentadienyl ligand) complexes were found to have selective activity against Mycobacterium smegmatis, with activity highly dependent upon the substituents on the Cp*R ligand as well as on the beta-diketonato ligand. These complexes were synthesized in good yield from the reaction of the chloro bridged dimers ([Cp*RMCl2]2) with the desired beta-diketonato ligand under basic conditions. All complexes were fully characterized by 1H and 13C NMR. Twenty single crystal X-ray structures were solved. The success of these syntheses led to investigation of another beta-diketonato ligand: 1,1,1,5,5,5-hexafluoroacetylacetonate (hfac). Though many metal complexes of this ligand are known, reaction with [Cp*MCl2]2 did not yield the desired Cp*M(hfac)Cl complexes. Instead, a variety of products were obtained, three of which were characterized crystallographically. The most interesting structure featured a non-coordinating trifluoroacetate (TFA) anion and a [Cp*Ir]3Na1O4 cubane structure, which is an unprecedented and highly unusual arrangement for iridium. Attempts to synthesize this cluster rationally through reactions of [Cp*IrCl2]2 with TFA yielded instead a chloro bridged [Cp*IrCl(TFA)] dimer. Reaction of [Cp*MCl2]2 with 1,1,1-trifluoroacetylacetonate (tfac) yielded the expected Cp*M(tfac)Cl complex, indicating that the problem lies with using hfac as a ligand for Cp*M(III) complexes. Finally, the indenyl effect was investigated for the oxidative annulation of 2-phenylimidazole with 1-phenyl-1-propyne catalyzed by a series of methyl-substituted [(indenyl)RhCl2] dimers. [(Ind*)RhCl2]2 was found to have significantly greater activity than [Cp*RhCl2]2 (100% vs. 51%). Two plausible catalytic cycles were proposed, one of which invokes a ring slip transition state. Though it is unclear if the "indenyl effect" is responsible for this differing activity, it is certainly apparent that using an indenyl ligand has a notable effect in this catalytic reaction. Cyclometalation was also investigated stoichiometrically for 2-phenyl-1H-imidazole and 1-phenylpyrazole and found to proceed readily for [(Ind*)RhCl2]2. Additionally, the crystallographic structure of a Rh+ /Rh– ionic pair was solved. Ionic pairs such as this are rarely found in the literature.
Doctor of Philosophy

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Xu, Feng, Satoko Ito, Michinari Hamaguchi, and Takeshi Senga. "Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/14175.

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Dunn, Timothy Alan. "The link between neuronal activity and activation of the cAMP/PKA cascade in developing retinal ganglion cells." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3311360.

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Thesis (Ph. D.)--University of California, San Diego, 2008.
Title from first page of PDF file (viewed July 30, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Phillips, Karen P. "Bicarbonate/chloride anion exchanger activity is cell cycle dependent during mouse oocyte meiotic maturation and egg activation." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9189.

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In the sea urchin, some other marine invertebrates, and the frog, Xenopus, egg activation at fertilization is accompanied by an increase in intracellular pH (pHi) resulting from activation of a pH i regulatory transporter. As pHi regulation had not been studied in a mammalian model, I investigated pHi regulation in the mouse egg during meiotic maturation and egg activation. Steady-state pH i was measured using the pHi sensitive fluorophore SNARF-1-AM in germinal vesicle (GV) oocytes, ovulated eggs, and zygotes. No sustained changes in pHi occurred after germinal vesicle breakdown (GVBD), fertilization or during parthenogenetic egg activation. HCO3-/Cl- exchanger activity was measured in unfertilized eggs and zygotes. Zygotes exhibited a marked intracellular alkalinization and Cl- efflux upon external Cl- removal, which is indicative of active HCO3-/Cl- exchangers, in contrast to the very small response observed in eggs. Furthermore, while zygotes quickly recovered from an induced alkalosis, eggs exhibited only a slow, incomplete recovery. HCO3-/Cl - exchanger activity was upregulated following in vitro fertilization (IVF) becoming maximal after 79 h. Activation of HCO3- /Cl- exchanger activity appeared to occur by activation of existing, inactive exchangers upregulation of activity was unaffected by inhibition of protein synthesis or by disruption of the Golgi apparatus or the cytoskeleton. HCO3-/Cl- exchanger upregulation was also independent of PKC and cAMP-dependent pathways. Using cycloheximide-activated eggs, HCO3- /Cl- exchanger activation was independent of the repetitive Ca2+i transients. HCO3-/Cl- exchanger activity, measured during the cell cycle, was robust in GV eggs, becoming downregulated during meiotic maturation. Low HCO3- /Cl- exchanger activity was a feature of meiotic metaphase only, as activity was not downregulated during metaphase of the first cell cycle. HCO3-/Cl- exchanger upregulation was dependent on an intact metaphase II spindle and could be blocked by the phosphatase inhibitor okadaic acid following Sr 2+ activation. Finally, HCO3-/Cl - exchanger activity could be activated in unfertilized eggs by the MEK inhibitor U0126. This suggests that HCO3- /Cl- exchanger activity is upregulated at fertilization in the mouse by a cell cycle-dependent mechanism that may involve the MAPK pathway.

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Fan, Wen-Lin. "Protein Kinase C Activation in Hyperglycemic Bovine Lens Epithelial Cells." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc500774/.

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This study demonstrates the presence of protein kinase C activity in both cytosolic and membrane fractions of bovine lens epithelial cells in culture. Protein kinase C activity is similar in normal and hyperglycemic cells. Furthermore, the ability of the enzyme to translocate from the cytosol to the membrane following phorbol ester treatment is unimpeded by hyperglycemic conditions. Moreover, protein kinase C activation had no effect on myoinositol uptake either in normal cells or in cells exposed to hyperglycemic conditions.

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Nkosi, Tumishang. "Aquaculture in South Africa : using the triple helix model to explore innovation activity in institutional spheres." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/52277.

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The quest for economic growth across the globe and the focus on Africa as an emerging economic giant are resulting in the need for appropriate structures aimed at nurturing the growth of regions in Africa. The decentralisation of globalisation in favor of regionalisation is accompanied by the requirement for regional competitiveness that is underpinned by innovation. The rapid pace of change as a characteristic of the modern day business environment highlights a paradigm shift of the generation and commercialisation of innovative new ideas. Collaboration in innovation introduces brand new ways of realising the benefits of recreating the roles and responsibilities of the three pillars of any given economy : the government, the academia and the industry. The main purpose of this study was to use the triple helix model of innovation to explore the model in practice within the context of an industry that has high growth potential but that was experiencing slugging growth, with the aim of identifying the structure of the triple helix system and the elements thereof that may be inhibiting the sector. Secondary data collection and primary data collection phases were used during the study, the latter of which was in the form of a qualitative data collection methodology. The first phase of secondary data collection was used to gain insights into an underdeveloped industry that was deficient of comprehensive industry information sources as a result of its development status. The output of the first phase of data collection was used as input to design a questionnaire to be to collect primary data. A sample of ten respondents was interviewed during the primary data collection process. The sample consisted of two respondents from the government, two respondents from academia and six respondents from industry. The outcome of the study revealed that the presence of a well-structured and well-functioning triple helix system did not guarantee collaborative innovation success. The absence legislation in a triple helix system seemed to weaken the benefits sought from a triple helix approach to innovation in a sector. The key finding of the study was that the rules of the game within a triple helix system should precede the efforts of managing the elements of the triple helix system. By setting the rules of the game upfront, the individual institutional spheres would be in a position to willingly adopt the roles of the other institutional spheres from a position of positive collaboration instead of frustration.
Mini Dissertation (MBA)--University of Pretoria, 2015.
ms2016
Gordon Institute of Business Science (GIBS)
MBA
Unrestricted

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