Journal articles: 'Acte abstrait'

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Gronewold, Thomas M. A., and Dale Kaiser. "act Operon Control of Developmental Gene Expression in Myxococcus xanthus." Journal of Bacteriology 184, no. 4 (February 15, 2002): 1172–79. http://dx.doi.org/10.1128/jb.184.4.1172-1179.2002.

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ABSTRACT Cell-bound C-signal guides the building of a fruiting body and triggers the differentiation of myxospores. Earlier work has shown that transcription of the csgA gene, which encodes the C-signal, is directed by four genes of the act operon. To see how expression of the genes encoding components of the aggregation and sporulation processes depends on C-signaling, mutants with loss-of-function mutations in each of the act genes were investigated. These mutations were found to have no effect on genes that are normally expressed up to 3 h into development and are C-signal independent. Neither the time of first expression nor the rate of expression increase was changed in actA, actB, actC, or actD mutant strains. Also, there was no effect on A-signal production, which normally starts before 3 h. By contrast, the null act mutants have striking defects in C-signal production. These mutations changed the expression of four gene reporters that are related to aggregation and sporulation and are expressed at 6 h or later in development. The actA and actB null mutations substantially decreased the expression of all these reporters. The other act null mutations caused either premature expression to wild-type levels (actC) or delayed expression (actD), which ultimately rose to wild-type levels. The pattern of effects on these reporters shows how the C-signal differentially regulates the steps that together build a fruiting body and differentiate spores within it.

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Lapointe, Gilles. "Ce tremblement sous la ligne." Études françaises 48, no. 2 (December 17, 2012): 93–109. http://dx.doi.org/10.7202/1013336ar.

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Qu’ont en commun l’art spiritualiste de Hector de Saint-Denys Garneau et le monisme de Paul-Émile Borduas ? Premier poète québécois à faire de la peinture un objet de réflexion esthétique, Saint-Denys Garneau tient pourtant en suspicion la modernité artistique, refusant « l’injure à l’art » que représentent pour lui le cubisme et l’art abstrait. Si l’ekphrasis, chez Saint-Denys Garneau, s’éloigne du « pittoresque » pour s’approcher du « pictural », l’idéalisation du sujet et l’objectivation de la vision qu’il cultive diffèrent cependant fortement de la conception du tableau de Borduas. Aux notions d’ordre, de centre, d’harmonie, d’unité, de transparence et d’élévation autour desquelles le poète et artiste ordonne encore le visible, Borduas oppose celles d’automatisme psychique, d’écriture automatique, de liberté du geste, de « désir-passion », de « grâce surrationnelle », appelant une exploration du chaos du monde intérieur et une plongée dans l’inconscient menant inéluctablement à un contact brutal avec la matière sensible. Prenant acte de l’apparition de Garneau et Borduas au même moment sur la scène publique montréalaise, vers 1937-1938, et cherchant à mesurer le pouvoir de séduction particulier qu’exercent sur eux durant ces années décisives la pensée et l’oeuvre de John Lyman, l’auteur interroge la conception antagoniste que chacun se forge du dessin et de la couleur et examine certains des enjeux essentiels, après la publication du Journal de Saint-Denys Garneau, qui déterminent la posture double et ambiguë de Borduas à l’endroit de l’héritage de l’écrivain.

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Gronewold, Thomas M. A., and Dale Kaiser. "Mutations of the Act Promoter in Myxococcus xanthus." Journal of Bacteriology 189, no. 5 (December 22, 2006): 1836–44. http://dx.doi.org/10.1128/jb.01618-06.

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ABSTRACT Mutations within the −12 and −24 elements provide evidence that the act promoter is recognized by sigma-54 RNA polymerase. Deletion of the −20 base pair, which lies between the two conserved elements of sigma-54 promoters, decreased expression by 90%. In addition, mutation of a potential enhancer sequence, around −120, led to an 80% reduction in act gene expression. actB, the second gene in the act operon, encodes a sigma-54 activator protein that is proposed to be an enhancer-binding protein for the act operon. All act genes, actA to actE, are expressed together and constitute an operon, because an in-frame deletion of actB decreased expression of actA and actE to the same extent. After an initially slow phase of act operon expression, which depends on FruA, there is a rapid phase. The rapid phase is shown to be due to the activation of the operon expression by ActB, which completes a positive feedback loop. That loop appears to be nested within a larger positive loop in which ActB is activated by the C signal via ActA, and the act operon activates transcription of the csgA gene. We propose that, as cells engage in more C signaling, positive feedback raises the number of C-signal molecules per cell and drives the process of fruiting body development forward.

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Haugen, Marius Warholm. "Traduire le Voyage comme acte politique." Revue Romane / Langue et littérature. International Journal of Romance Languages and Literatures 55, no. 2 (August 7, 2019): 191–213. http://dx.doi.org/10.1075/rro.17016.hau.

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Abstract This article studies the discourse in the late eighteenth- and early nineteenth-century French periodical press on the topic of translations of travel writing. It reveals that travel reviews were arenas for discussing the political and ideological value of translating travelogues into French, notably from English. In the context of the Franco-British conflicts at the turn of the century, the French press perceived translations of British travel writing as potential patriotic tools that allowed different ways of countering or subverting British global influence. Paratextual elements of translations, the translator’s prefaces and notes, appeared to be particularly important in this respect. By analysing the periodical discourse on travel book translations, the article shows how travel writing was constructed as a politically invested genre.

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Refojo, Patrícia N., Filipa Calisto, Miguel A. Ribeiro, Miguel Teixeira, and Manuela M. Pereira. "The monoheme cytochrome c subunit of Alternative Complex III is a direct electron donor to caa3 oxygen reductase in Rhodothermus marinus." Biological Chemistry 398, no. 9 (August 28, 2017): 1037–44. http://dx.doi.org/10.1515/hsz-2016-0323.

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Abstract Alternative Complex III (ACIII) is an example of the robustness and flexibility of prokaryotic respiratory chains. It performs quinol:cytochrome c oxidoreductase activity, being functionally equivalent to the bc1 complex but structurally unrelated. In this work we further explored ACIII investigating the role of its monoheme cytochrome c subunit (ActE). We expressed and characterized the individually isolated ActE, which allowed us to suggest that ActE is a lipoprotein and to show its function as a direct electron donor to the caa3 oxygen reductase.

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FUERST, A., G. BRUBACHER, W. MEIER, and A. RUETTIMANN. "ChemInform Abstract: Helvetica Chimica Acta and the Vitamins." ChemInform 24, no. 25 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199325301.

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Hulmani, Manjunath, Asha Bullappa, Shruti Kakar, and Prakash Kengnal. "Knowledge, attitude and practice towards acne vulgaris among acne patients." International Journal of Research in Dermatology 3, no. 1 (February 23, 2017): 107. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20170797.

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Background: Acne is a chronic inflammatory disease known to occur in adolescent age group. There are many myths and misconceptions in patients as well as health physicians regarding the causes and treatment of acne. Objective of the study was to assess the knowledge, attitude and practice towards acne vulgaris among acne patients attending skin outpatient department in a private medical college.Methods: This is a cross sectional, questionnaire based study conducted between January - April 2016. 100 patients having acne lesions were included in the study.Results: Majority of the study subjects belonged to the age group 15-24. The study showed that 72% had good knowledge. More than half of the study subjects had wrong belief that eating oily foods, chocolates, spicy food caused acne but more than 40% of the study subjects had good knowledge about the causes and aggravating factors like it worsens by squeezing/picking/rubbing (83%), commonly found in oily skin (67%), has seasonal occurrence (54%), associated with premenstrual flare (42%), aggravated with use of cosmetics (41%). Conclusions: The acne patients had poor practice and unfavorable attitude in spite of good knowledge. Many myths exist among patients. Despite being so common and very well responsive to treatment, it is a major cause of depression among patients.

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Dreno, B., R. Martin, A. Khammari, D. Moyal, J. B. Henley, and S. Seite. "Skin Microbiome and Acne Vulgaris: Staphylococcus, a New Actor in Acne." SKIN The Journal of Cutaneous Medicine 1 (October 27, 2017): s54. http://dx.doi.org/10.25251/skin.1.supp.53.

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Koga, Monji, and Shinichi Imafuku. "Frequency of Acne and Acne Scars in Patients with Neurofibromatosis 1." Acta Dermato-Venereologica 104 (January 10, 2024): adv18621. http://dx.doi.org/10.2340/actadv.v104.18621.

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Tiburcio, Patricia Denise Ballesteros, and Kenneth S. Chen. "Abstract 2689: Targeting the proteasome pathway in dactinomycin resistant Wilms tumors." Cancer Research 83, no. 7_Supplement (April 4, 2023): 2689. http://dx.doi.org/10.1158/1538-7445.am2023-2689.

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Abstract Nephroblastomas or Wilms tumors are the most common pediatric renal cancer. Across all cases, the 5-year overall survival is over 90%. This is largely in part due to brute-force, chemotherapy regimens such as dactinomycin (actD) that have been routinely used to treat Wilms tumors. However, those that do respond to treatment still face a 15% chance of relapse. Patients with anaplastic tumor histology require more toxic therapies, and yet they still face a worse prognosis of only 66% 4-year survival and relapse rate of 43%. Furthermore, recurrence cuts survival rate down to 50%. With the widespread use of actD in Wilms tumors and other childhood malignancies, understanding the mechanism to recalcitrance against this chemotherapy can potentially reveal important vulnerabilities that can be exploited in the clinic. While transcriptomic and genomic analyses have been done in Wilms tumors, no targetable pathways have been identified in actD chemotherapy-resistant and anaplastic tumor cases. To that end, we performed ribosome sequencing of actD-treated anaplastic Wilms tumor cell line WiT49 and uncovered that the proteasome pathway is preferentially translated. Moreover, loss of proteasome subunits in a CRISPR library dropout screen sensitized the cells to actD. Consistent with these findings we found upregulation of proteasome subunit levels and proteasome enzymatic activity in Wilms tumor lines following actD treatment. To interrogate the effect of cotreating bortezomib with dactinomycin in vivo, we subcutaneously implanted anaplastic Wilms tumor patient-derived xenograft (PDX) lines in NOD/SCID Gamma (NSG) mice. Combinatorial treatment was found to be retard tumor growth compared to vehicle and single drug conditions. With further investigation, our findings can provide a foundation for exploring proteasome inhibitors with dactinomycin in clinical trials. Our study has important implications to improving the outcomes for not just for recurrent and anaplastic Wilms tumors, but to other pediatric cancers that use actD as well. Citation Format: Patricia Denise Ballesteros Tiburcio, Kenneth S. Chen. Targeting the proteasome pathway in dactinomycin resistant Wilms tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2689.

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Adeluola, Adeoluwa A., and A. R. M. Ruhul Amin. "Abstract 1837: Low dose actinomycin D preferentially activates p53-p21 pathway in aerodigestive tract cancers: Implication for cyclotherapy." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1837. http://dx.doi.org/10.1158/1538-7445.am2022-1837.

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Abstract Actinomycin D (ActD) was the first anti-cancer antibiotic approved for the management of human cancers. However, the notorious toxicity profile limits its widespread application in cancers including cancers of the aerodigestive tract. Recent studies show that combining low-dose ActD with existing chemotherapies could potentially reduce the toxicity of chemotherapy drugs through p53 mediated cyclotherapy (protection of normal cells while eliminating cancer cells), a recently coined concept. An understanding of ActD’s effect on p53 signaling is critical for meaningful application of ActD in cyclotherapy-based combinations. This study evaluated the antitumor efficacy and mechanism of action of ActD in aerodigestive tract cancers. We found that ActD strongly inhibited the growth of a panel of aerodigestive tract cancer cell lines and induced efficient apoptosis although the sensitivity varies among cell lines. The IC50 values of ActD spanned between 0.021-2.96nM. Mechanistic studies revealed that ActD time- and dose-dependently increased the expression of total and phosphorylated p53 (ser15). Furthermore, ActD-induced apoptosis is dependent on p53 in cells expressing wild-type p53. Further studies demonstrated that ActD induced context-dependent differential expression of downstream targets p21 and PUMA without significant effects on p27. Interestingly, our study revealed that p53-p21 is the predominant pathway activated by low-dose ActD in cells with wild type p53. Therefore, our findings further rationalize the premise for future studies to explore the application of low-dose ActD as a chemoprotectant for cyclotherapy combinations in aerodigestive tract cancers. (Supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence) Citation Format: Adeoluwa A. Adeluola, A. R. M Ruhul Amin. Low dose actinomycin D preferentially activates p53-p21 pathway in aerodigestive tract cancers: Implication for cyclotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1837.

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Chalke, Vidhi, Gourvi Kala, Shruti Kadam, Manasi Tawade, and Ms Vaishali Rane. "Menstrual Period Calendar Application." International Journal for Research in Applied Science and Engineering Technology 10, no. 5 (May 31, 2022): 1057–63. http://dx.doi.org/10.22214/ijraset.2022.42444.

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Abstract: This paper describes about a solution to a woman’s needs during their menstruation. This is a paper on a mobile app created by Vidhi Chalke, Gourvi Kala, Shruti Kadam, Manasi Tawade as our final year project. The name of the app is KNOW YOUR DATE. Anyone who has experienced a period knows that the whole affair can be tricky, which is why finding the best period tracker app is a worthy pursuit. Even if your cycle is regular, it probably comes with a whole of a lot things like mood changes, acne, body ache, and other symptoms. If you're someone who deals with a reproductive issue like endometriosis, fibroids, or polycystic ovary syndrome (PCOS), understanding your cycle as much as possible has major benefits. In short: if you are a menstruating human, a period app can probably make things a little easier. Keywords: menstruation, cycle, periods, calendar, app

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Sajeed, Aneesa, Yogesh Devaraj, Belagola D. Sathyanarayana, Mukunda Ranga Swaroop, and Shruti Bidarkar. "A clinicoepidemiological study of adult acne." International Journal of Research in Dermatology 6, no. 1 (December 23, 2019): 84. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20195679.

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Background: Acne vulgaris is a chronic inflammatory dermatosis of pilosebaceous unit. Adult acne is defined as presence of acne after the age of 25 years. Though acne vulgaris has been studied extensively, there is paucity of literature on adult acne.Methods: A total of 150 patients with adult acne were enrolled in the study. A detailed history was taken followed by detailed dermatological examination. Ultrasonography abdomen and pelvis, hormonal evaluation was done in case of women with symptoms and signs of hyperandrogenism.Results: Out of 150 patients studied, majority (61.3%) were in the age group of 26-30 years. The mean age of patients with adult acne was 30.1 years. Females (86%) outnumbered males. Majority of the patients (53.3%) had persistent adult acne and 46.7% had late onset acne. Exposure to sunlight (24%) was the most common aggravating factor followed by use of cosmetics in 19.3%. Menstruation was causing flare up of acne in 72 (55.8%) female patients. Face was involved in all the patients. Cheek was the most common site involved followed by forehead. Post acne scarring was present in 46.6% of the patients. Majority of the patients (67.3%) had grade 2 acne. Symptoms and signs of hyperandrogenism were present in 14 female patients.Conclusions: Adult acne is more common in females. Persistent acne is more common than late onset acne. Patients with persistent adult acne are more prone to develop nodulocystic acne and acne scars.

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Broberg, Morten, and Niels Fenger. "If You Love Somebody Set Them Free: On The Court Of Justice’S Revision Of The Acte Clair Doctrine." Common Market Law Review 59, Issue 3 (June 1, 2022): 711–38. http://dx.doi.org/10.54648/cola2022050.

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In its 2021 ruling in Consorzio, the European Court of Justice adopted a more pragmatic approach to its acte clair doctrine. This article analyses this reform and shows that in important respects the Court has eased the requirements for finding a question of EU law to be acte clair. Simultaneously, the Court has introduced a duty for national courts of last instance to give reasons where they are faced with questions of EU law and decide not to make a preliminary reference. The article also considers the Court’s discreet change of approach regarding the application (rather than the interpretation) of EU law by national courts of last instance as reflected in the Consorzio ruling, and argues that there is acte clair where the abstract interpretation of EU law is clear and leaves no scope for any reasonable doubt, even if the national court of last instance entertains doubts as to the correct application of said EU law to the case at hand.

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Perrin, Bertrand. "L’incrimination du financement du terrorisme en droits canadien et suisse." Revue générale de droit 42, no. 1 (September 22, 2014): 213–65. http://dx.doi.org/10.7202/1026922ar.

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Deux définitions du terrorisme coexistent au Canada, l’une en matière pénale et l’autre dans le domaine de l’immigration. Le droit suisse n’incrimine que le financement du terrorisme. Contrairement au droit canadien, la Suisse a opté pour une norme générale et abstraite inspirée de la Convention internationale pour la répression du financement du terrorisme. La loi suisse n’exige pas que l’acte terroriste soit commis au nom d’un but, d’un objectif ou d’une cause de nature politique, religieuse ou idéologique. Cette solution est préférable. Par contre, le législateur suisse a exclu expressément l’incrimination du dol éventuel. Le droit canadien offre, dans ce cas, une possibilité d’incrimination plus large, davantage favorable à la mise en œuvre effective du droit pénal. En outre, le droit suisse ne sanctionne que le soutien financier à un acte terroriste précis, le droit canadien ayant dans ce cas aussi un champ d’application plus étendu et plus adapté. En droit canadien, l’incrimination du financement du terrorisme pourrait s’inspirer de la formulation suivante : « Est coupable d’un acte criminel passible d’un emprisonnement maximal de dix ans quiconque, directement ou non, fournit ou réunit des fonds, dans l’intention de les voir utiliser ou en sachant qu’ils seront utilisés pour financer un acte — ou une entité dont l’un des objets ou l’une des activités est de se livrer à ce type d’actes — destiné à tuer ou blesser grièvement un civil, ou toute autre personne qui ne participe pas directement aux hostilités dans une situation de conflit armé, lorsque, par sa nature ou son contexte, cet acte vise à intimider une population ou contraindre un gouvernement ou une organisation internationale à accomplir ou à s’abstenir d’accomplir un acte quelconque ».

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Milinis, Albertas, and Kristina Pranevičienė. "Conditions and Circumstances which Lead to Application to the Court of Justice of the European Union and Adoption of a Preliminary Ruling." Baltic Journal of Law & Politics 9, no. 2 (December 1, 2016): 130–49. http://dx.doi.org/10.1515/bjlp-2016-0015.

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Abstract This article deals with the issues concerning the communication between the national courts of the European Union Member States and the Court of Justice of the European Union via the preliminary ruling procedure. The doctrines of acte clair and acte éclairé are described briefly in the article. The authors explicitly investigate the national court’s right to apply to the Court of Justice of the European Union and the obligation to apply to the Court of Justice of the European Union for a preliminary ruling. The recent tendencies in the jurisprudence of the national courts of the Republic of Lithuania while applying for preliminary rulings are revealed.

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Eram, Hafsa, Vinma H. Shetty, Saumya Goel, and Amita Murali Babu. "Quality of life in patients with acne vulgaris in a tertiary care centre: a cross sectional study." International Journal of Research in Dermatology 5, no. 2 (April 26, 2019): 406. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20191770.

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Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous units which has great psychological impact and causes depression, anxiety, and low self-esteem.Methods: It was a hospital-based, cross-sectional, prestructured, questionnaire-based study done in 120 individuals in the age group 12-30 years using two specific HRQoL indices-Cardiff Acne Disability Index (CADI) and Acne-speciﬁc Quality of Life (Acne-QOL) to understand the impact of acne on the quality of life.Results: Male to female ratio was 2:3. The mean age was 19.23±1.7. The mean CADI score was 5.3. Majority of the patients had grade 2 acne. Based on the CADI questionnaire, the number of males (61.7%) and females (60.2%) was maximum in the medium score. Grade 1 acne had maximum number of patients showing low score followed by grade 2 acne. Based on the acne-QoL questionnaire, maximum patients were in the 11-20 score range, followed by the 21-30 score range.Conclusions: Acne is not only a cosmetic problem, but also has significant psychological impact. Hence, impact of acne on QoL must be considered in the management of facial acne.

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Karappally, James Joseph, Razeena Padmam, and George Kurien. "A study on the quality of life and adjustment of adolescents with acne vulgaris." International Journal of Research in Dermatology 4, no. 3 (July 24, 2018): 415. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20183168.

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Background: Acne vulgaris is a seemingly harmless disease affecting majority of adolescents. It is actually a psycho-dermatological disorder associated with psychological trauma. The impact of acne on the quality of life of Indian patients remains undocumented. A study is undertaken to assess the impact of acne on health, family, emotional and social wellbeing of acne patients.Methods: 100 patients between age group of 13 to 19 years with acne vulgaris, attending St. Antony’s Skin Clinic, Pala, Kerala, between April 2010 and March 2012 were selected for study. The control group consisted of 100 adolescents without acne. Both groups had no other dermatological or systemic disease. Acne cases were graded using global acne grading system. Quality of life was assessed using WHO QOL BREF.Four domains were derived from this, physical and psychological health, social relationship and environment. Adjustment levels were assessed using adapted version of bell adjustment inventory.Results: The parameters assessed were quality of life, family, social, emotional, health related and overall adjustments in those with and without acne and severity of acne in relation to quality of life and all values were significantly in favour of those without acne.Conclusions: Acne affects personality, self-esteem and self-image of patients. It affects social interaction. Adolescents with acne report low quality of life and resultant poor psychosocial adjustment. There is an inverse relation between severity of acne and quality of life. The severity levels and adjustment also has an inverse relationship.

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Asghar, Aneela, Qurrat-ul-ain Minhas, and Muhammad Asghar Butt. "MANAGEMENT OF ACNE." Professional Medical Journal 23, no. 02 (February 10, 2016): 228–32. http://dx.doi.org/10.29309/tpmj/2016.23.02.1462.

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ABSTRACT…Objective: To highlight the errors in the management of acne by GPs, qualifieddermatologists having minor degrees or fellowship and those who do not have any qualificationand practicing as dermatologists. Study design: Observational case series study. Setting:Dermatology department, Allied and D.H.Q hospitals, Faisalabad and at private setup.Period: From September 2012 to September 2013. Material & Methods: 100 patients withacne were divided in four groups. Those treated by general practitioners, those treated bydermatologists with minor degrees and diplomas, those with fellowship and those who practiceas dermatologists but they don’t have any qualifications. Results: None of the patients wasassessed properly for severity of acne and none of them was being treated according to thecurrent recommendations. Conclusion: General practitioners and dermatologists still needextensive education regarding the treatment of this common skin disease.

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Abedzadeh-Anaraki, Sanaz, Chitharanjan Duvoor, Mauricio Moreno, and Elena Ambrogini. "Abstract #710: Always Acted as Paraganglioma; Always Read as Schwannoma." Endocrine Practice 23 (April 2017): 136–37. http://dx.doi.org/10.1016/s1530-891x(20)44505-7.

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BUERGI, H. B., and J. D. DUNITZ. "ChemInform Abstract: Structural Chemistry in Helvetica Chimica Acta, 1917-1992." ChemInform 24, no. 33 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199333340.

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ZOLLINGER, H. "ChemInform Abstract: Color Chemistry as Reflected in Helvetica Chimica Acta." ChemInform 24, no. 2 (August 21, 2010): no. http://dx.doi.org/10.1002/chin.199302320.

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Adel, Shereen, Talal A. Abd-El-Raheem, Ghada Ezzat, and Nermeen M. Ismail. "Role of insulin-like growth factor 1 in pathogenesis of acne vulgaris: relation to acne severity and body mass index." International Journal of Research in Dermatology 6, no. 2 (February 24, 2020): 147. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20200593.

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<div class="Section1">Background: Acne vulgaris is a multifactorial skin disease. A potential role for insulin-like growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1 correlate with overproduction of sebum and acne. Objective: Measurement of the serum level of IGF-1 in acne patients in comparison to normal controls and evaluating the relationship of these levels to severity of acne and body mass index (BMI), in order to investigate the role of this factor in the pathogenesis of acne.Methods: Fifty-four patients with acne vulagaris and 42 healthy controls were included. History taking, dermatological examination, clinical assessments of acne severity, calculation of BMI were performed for patients. Blood samples were collected from all participants for estimation of serum IGF-1 level using enzyme linked immunosorbant assay.Results: There was a significantly higher serum IGF-1 level in acne patients (p<0.05) than controls. Authors didn’t find a relation of significance between elevated serum IGF-1 level and degree of acne severity and BMI (p>0.05). There was a significant positive correlation between serum IGF-1 level and age of the patients.Conclusions: There is a significantly higher serum IGF-1 in acne patients than controls not related to acne severity and BMI. That is adding to the scientific evidence of IGF-1 role in pathogenesis of acne vulgaris.</div>

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Kundale, Darshana R., Anil P. Gosavi, Ravindranath B. Chavan, and Neelamkumari Bhatt. "Dermatology life quality index in patients of acne vulgaris presenting to a tertiary care hospital: an observational study." International Journal of Research in Dermatology 7, no. 5 (August 23, 2021): 692. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20213345.

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Background: Acne vulgaris is a common, chronic disorder resulting from the inflammation of pilosebaceous unit, present with clinically various forms. It is usually prevalent in adolescent may persist in adulthood. This study was conducted to evaluate the quality of life (QoL) in patients suffering from acne vulgaris.Methods: Hospital based cross sectional study was conducted in 60 patients. Dermatology life quality index (DLQI) questionnaire was used to observe the effect of acne among patients.Results: Total numbers of patients enrolled were 60 (43 females,17 males). The mean age was 24.85±5.63 years. Maximum patients were of the age group 26-30 years (22 patients; 36%) and least were of 31-36 age group. Out of 60 patients, 29 patients had grade II acne followed by 20 with grade I acne, grade III acne was present in 11 patients. Most of the patients 31 (52%) were having “moderate impact” on quality of life followed by 23 (38%) with “small impact” on QOL. There was a significant positive correlation between grade of acne and DLQI (Pearson correlation=0.753, p=0.00).Conclusions: Our study showed significant impairment of QoL in acne patients. DLQI increases with increase in severity of acne. Treatment of acne should not be guided only by the clinical grade of acne, but take into consideration the psychosocial impact the condition has on the patient. Adequate counselling along with early treatment of acne vulgaris is essential in order to reduce the disease related psychosocial sequelae and increase treatment efficacy.

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Thomas, Jacob. "Role of zinc in acne: a study of 77 patients." International Journal of Research in Dermatology 4, no. 3 (July 24, 2018): 301. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20182980.

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Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit occurring in adolescent age group. Though not life threatening it can cause physical and psychological scars which can produce social problems in house, school and office. It is a multifactorial disease. Many treatment options are available, but not optimal. Zinc was found to be effective in pustular acne in a patient with acrodermatitis enteropathica. Hence a study on the level serum zinc in acne patients and the effect of zinc on acne is worthwhile. The aim was estimation of serum zinc level in acne patients and correlation of serum zinc level and improvement of acne.Methods: Pre-treatment serum zinc level was estimated in acne and non-acne patients. Acne patients were given oral zinc 220 mg two times a day and control group was given placebo. Post treatment serum zinc levels were estimated and the serum zinc level and improvement of acne was correlated.Results: Study subjects attained average serum zinc level of 5.829 µg/ml from 1.33 µg/ml. 59.5% patients on zinc therapy showed more than 50% improvement in acne severity. 10.6% showed >75%, 48.9% showed 50-75%, 36.1% showed 25-50% and 4.25% patients showed less than 25% improvement.Conclusions: Statistically significant low levels of zinc were not observed in acne. Oral zinc sulphate 220 mg two times a day raised serum level to 5.82 µg/ml Exponential response in acne was noticed as serum zinc level was raised. Inflammatory lesions showed better response than comedo. Oral zinc has definite role in treatment of acne.

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Saxena, Kshitij, Yogesh M. Shah, K. K. Singh, Shobhit Dutt, Meenal Agrawal, and Nishant Singh. "Clinical profile of acne vulgaris in semiurban patients." International Journal of Research in Dermatology 4, no. 1 (January 23, 2018): 23. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20180120.

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Background: Acne is a chronic inflammatory disease of the pilosebaceous unit, mainly affecting face and frequently followed by scarring. It is the most common skin disease in an urban dermatology clinic in India. Adult acne is more common in women and may be a marker of hyperandrogenism.The present study was carried out to study the clinical profile of acne vulgaris in semiurban patients.Methods: The study was conducted for 1 year on all eligible patients of acne vulgaris attending dermatology OPD of a hospital catering to semiurban patients. Data including grade of acne, markers of androgenicity and post-acne scarring was collected. Statistical analysis was done using SPSS 15 software.Results: Frequency of acne vulgaris patients in the dermatology OPD was 2.8% with 429 acne patients out of 15,322 new patients. Female to male ratio was 1.44:1. The mean age of onset in males was 16.24 and in females, 14.84 years. Grade 2 acne (66%) was commonest followed by grade 3 (5.1%) and grade 4 (3.7%). Associated conditions seen were seborrhea (60.8%), alopecia (18.9%), acanthosis (4.9%) and PCOD (2.3%). Markers of androgenicity were more frequently seen in grade 2 acne which was statistically significant. Atrophic scars were commonest including icepick scars (80.2%), rolling scars (67.4%) and box scars (57.8%). Conclusions: In our study females had an earlier onset and closed comedones were the most common acne lesion. Grade 2 acne vulgaris formed majority of patients. Grade 4 acne vulgaris was more common in males.

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Peretti, Pascale. "Renaître du coma comme expérience exilaire de « seconde mort »." Études sur la mort 158, no. 2 (July 18, 2023): 105–23. http://dx.doi.org/10.3917/eslm.158.0105.

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À partir d’un référentiel psychanalytique, et sur la base d’un cas clinique, l’article interroge l’expérience subjective du coma comme épreuve exilaire, de « seconde mort », d’où le sujet, arraché à ses fondements symboliques, pourrait « renaître » à son ex-istence sur la base d’un choix ou assentiment intérieurs, d’une détermination qui vaut comme acte décisionnaire. Lequel acte souligne au fond la ligne de partage entre « vie nue » et existence, aussi bien qu’entre mort réelle et mort symbolique, tout en impliquant une véritable « traversée », migration ou transmutation subjective. Ligne de partage qui dessine peut-être également le seuil à partir duquel le sujet peut exercer sa dignité, notion morale abstraite qu’il s’agit aussi de questionner ici, à travers différents motifs, du point de vue notamment de ses enjeux psychiques.

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Sivaramakrishnan, Sangaiah, and Thomas Jayakar. "A study on the dermatology life quality index in patients with acne vulgaris." International Journal of Research in Dermatology 5, no. 4 (October 21, 2019): 774. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20194667.

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Background: Acne vulgaris is a common, chronic disorder, involving inflammation of the pilosebaceous units that can be varied in presentation and difficult to treat. Most adolescents experience some acne; however, it may linger into adulthood. This study was done to evaluate the dermatology life quality index in patients with acne vulgaris.Methods: A cross sectional study was done with pretested Dermatology life quality index (DLQI) questionnaire on 100 acne patients 15 years and above, in a tertiary care hospital. Interpretation of score and impact on quality of life (QoL) was done and graded as no effect, small effect, moderate effect, and very large effect.Results: In our study, females outnumbered males (M: F ratio=1: 1.22). The age group most affected was within 15 and 20 years of age. The mean DLQI score was 5.59±4.07. Most of them had a ‘small impact’ on the QoL. QoL was worse in females. The most common grade of acne overall was grade 2 acne. Grade 3 acne was more common in men. Most of the patients (84%) experienced some degree of embarrassment or increased self-consciousness due to their acne.Conclusions: Our study showed significant impairment of QoL in acne patients. Treatment of acne should not be guided only by the clinical grade of acne, but take into consideration the psychosocial impact the condition has on the patient. Adequate counselling along with early treatment of acne vulgaris is essential in order to reduce the disease-related psychosocial sequelae and increase treatment efficacy.

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KALVODA, J. "ChemInform Abstract: 60 Years of Steroid Chemistry in Helvetica Chimica Acta." ChemInform 24, no. 14 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199314312.

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HEIMGARTNER, H., and H. J. HANSEN. "ChemInform Abstract: Organic Photochemistry in the Mirror of Helvetica Chimica Acta." ChemInform 24, no. 33 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199333309.

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Tsukii, Rika, Yuka Kasuya, and Shinji Makino. "Acute anterior uveitis following severe acute respiratory syndrome coronavirus 2 infection." International Journal of Case Reports and Images 13, no. 2 (September 23, 2022): 152–53. http://dx.doi.org/10.5348/101348z01rt2022cr.

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Tsukii, Rika, Yuka Kasuya, and Shinji Makino. "Acute anterior uveitis following severe acute respiratory syndrome coronavirus 2 infection." International Journal of Case Reports and Images 13, no. 2 (September 24, 2022): 151–52. http://dx.doi.org/10.5348/101348z01rt2022ci.

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Lawal, Qudus, Kasimu Umar Adoke, Jummai Jimeta Tuko, Aminu Magashi Garba, and Ishak K. Lawal. "Abstract 53: Implementing Equitable Cancer Support Program: Lessons From Cervical Cancer Chemotherapy Access Program (C3AP)." Cancer Epidemiology, Biomarkers & Prevention 32, no. 6_Supplement (June 1, 2023): 53. http://dx.doi.org/10.1158/1538-7755.asgcr23-abstract-53.

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Abstract Purpose: There is an inverse relationship between diagnosis to initiation of treatment interval and outcome of cancer treatment. A significant number of diagnosed cervical cancer patients don’t receive timely treatment in low resource settings. The Cervical Cancer Chemotherapy Access Program (C3AP) is one of End Cervical Cancer Nigeria Initiative’s interventions to IMProve Access to Cervical Cancer Treatment (IMPACT) in low resource settings. This report provides documentary evidence of the evolution of the implementation of the C3AP and highlights best practices that can be scaled up. Methods: The C3AP was conceptualized to increase the proportion of diagnosed cervical cancer patients that receive timely treatment by exploring adjuvant and neoadjuvant role of chemotherapy in the management of cervical cancer patients in settings where access to radiotherapy services can not be guaranteed. We instituted Plan Do Study and Act (PDSA) quality improvement cycle for the C3AP and used RE-AIM framework to study the implementation processes to be acted upon as part of the PDSA quality improvement process towards improving reach of the program. Results: The C3AP supported treatment of only 4 patients over the reporting period of 5months. Poor referral to the program is a major hurdle the program is battling. Only 2(17%) of the 12 confirmed cases of cervical cancer diagnosed in the facility within the 5month study period were able to access chemoradiation, suggesting a missed opportunity for 6/10(60%) that couldn’t afford chemoradiation. The program evolved over a PDSA cycle to eliminate social eligibility in the criteria to access the support thereby able to shorten application -support interval to same day with potential positive impact on prognosis. Conclusion: Providing equitable support for indigent cancer patients should be beyond the emotion to help humanity. We recommend the use of structured quality improvement for all programs providing support to indigent cancer patients to ensure implementation fidelity. Citation Format: Qudus Lawal, Kasimu Umar Adoke, Jummai Jimeta Tuko, Aminu Magashi Garba, Ishak K. Lawal. Implementing Equitable Cancer Support Program: Lessons From Cervical Cancer Chemotherapy Access Program (C3AP) [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 53.

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Temiz-Arpaci, Ozlem, Mustafa Arisoy, Duygu Sac, Fatima Doganc, Meryem Tasci, Fatma Sezer Senol, and Ilkay Erdogan Orhan. "Biological evaluation and docking studies of some benzoxazole derivatives as inhibitors of acetylcholinesterase and butyrylcholinesterase." Zeitschrift für Naturforschung C 71, no. 11-12 (November 1, 2016): 409–13. http://dx.doi.org/10.1515/znc-2016-0087.

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Abstract A series of 2,5-disubstituted-benzoxazole derivatives (1–13) were evaluated as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results demonstrated that the compounds exhibited a broad spectrum of AChE and BChE inhibitory activity ranging between 6.80% and 90.21% except one compound which showed no activity against AChE at the specified molar concentration. Another derivative displayed a similar activity to that of reference drug (galanthamine) for inhibition of AChE and BChE. In addition, molecular docking of the compounds into active site of AChE was performed using recombinant human AChE (PDB ID: 4ey6) in order to understand ligand–protein interactions.

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Raikar, Dayanand R., and Nagendra S. Manthale. "A cross sectional study of self-medication for acne among undergraduate medical students." International Journal of Research in Dermatology 4, no. 2 (April 25, 2018): 211. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20181821.

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Background: Acne is one of the most common inflammatory chronic skin diseases that affect teenagers and continues into adulthood. Self-medication is common among medical students. Hence this present study was undertaken to study the knowledge, attitude and practice of self-medication for acne among medical students.Methods: This cross-sectional study included medical students of the second phase and final phase (Part I and Part II). A pretested questionnaire was given to them which included questions on knowledge, attitude and practice about self-medication for acne.Results: Self-medication for acne was seen in 240 (77.4%) students out of 310 students. Mild nature of illness was the most common reason for self-medication for acne followed by privacy. Most common source of information was seniors/friends/family members. Most of the students felt that self-medication is part of self-care (48%). Clindamycin was the most common drug self-medicated for acne.Conclusions: Self-medication for acne is quite high among medical students. Self-medication is part of self-care so it should be encouraged for minor illness. But should be based on thorough knowledge and restricted to over the counter drugs.

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Shah, Nidhi, Faaria Ali, Aswathy Radhakrishnan, Parag Chaudhari, Anant Patil, and Sharmila Patil. "Clinical and epidemiological characteristics and hormonal profile of adult females with acne vulgaris: a cross-sectional study from a tertiary care hospital." International Journal of Research in Dermatology 7, no. 3 (April 27, 2021): 440. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20211706.

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Background: To study clinical and epidemiological characteristics and hormonal profile of adult females with acneMethods: Adult female patients of >25 years of age with acne were enrolled. Demographic profile, habits, location of acne lesions, associated disease and acne flare association with menstrual cycle were noted. Prevalence of abnormalities in testosterone, dihydroepiandrosterone-sulfate (DHEAS), prolactin, luteinizing hormone (LH), follicle stimulating hormone (FSH), LH:FSH ratio, anti-mullerian hormone (AMH), and serum insulin were noted. Ultrasound (abdomen and pelvis) was performed for screening the presence of any abnormality.Results: Fifty one patients [mean (SD) age 30.96 (4.93) years] were included in the study. Thirty six (70.59%) patients had persistent type of acne. Grade 2 acne was present in 40 (78.43%) patients. Oily skin was seen in 27 (52.94%) patients. Hirsuitism and menstrual irregularity was present in 24 (47.06%) and 13 (25.49%) patients respectively. Pigmentation and scarring was present in 27 (52.94%) and 35 (68.63%) patients respectively. Acne lesions were seen on cheeks in 36 (70.59%) patients. Eight (15.69%) patients had elevated testosterone. DHEAS and prolactin levels were normal in all patients. Elevation of LH and decreased FSH levels were seen in five (9.80%) and three (5.88%) patients respectively. Five (9.80%) patients had elevated LH:FSH level. Raised insulin level was seen in 8 (15.69%) patients.Conclusions: Derangement of hormonal profile is not very common among adult female patients with acne. However, in some patients laboratory markers of hyperandrogenism are seen.

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Raghavan, Jisy S., Sharim Fathima, Suhaiba Ameera, and Kunnummal Muhammed. "Clinical profile of acne vulgaris: an observational study from a tertiary care institution in Northern Kerala, India." International Journal of Research in Dermatology 5, no. 3 (July 24, 2019): 476. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20192135.

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Background: Acne is one of the most common disease affecting adolescence. Although prior studies have evaluated epidemiologic patterns of acne in different ethnicities and regions, literature is lacking from this part of the country. The objectives of the study were to delineate the clinical and epidemiological profile of acne vulgaris in a population from northern Kerala in South India.Methods: The study was carried out for 6 months and it included 100 patients. Epidemiology including pattern, aggravating factors, seasonal variation, diet, smoking, markers of androgenecity and associations were evaluated in all newly diagnosed cases of acne vulgaris who attended the outpatient department in Kannur Medical College, Kannur, Kerala, India from January 2018 to June 2018.Results: Out of 100 patients females (74%) outnumbered males (26%) and although the majority affected belonged to the age group of 21-25 years (38%), adult acne was observed in 28%. Grade 3 acne was the commonest (44%), followed by grade 2 (30%) and grade 4 (18%). Face was affected in all patients with cheeks (91%), followed by forehead (72%), mandible (36%) and chin (28%) and trunk (23%). Scarring was found in 34% and pigmentation in 40%. Family history of acne was observed in 33%.Conclusions: This study brings out the clinical profile of acne in a tertiary care hospital in South India.

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Anaba, Ehiaghe L., and O. O. Adebola. "Quality of life of adolescents with facial acne vulgaris before and after treatment in Ibadan, Nigeria." International Journal of Research in Dermatology 5, no. 1 (January 25, 2019): 155. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20190230.

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Background: Adolescent facial acne vulgaris impairs their quality of life (QOL). This impairment of QOL in has been documented to improve with treatment. In Nigerian adolescents who have facial acne vulgaris, it is not known if QOL improves with treatment. The aim was to assess QOL improvement with in adolescents who have facial acne vulgaris. To identify the socio-demographic, CADI QOL items and clinical characteristics related to this QOL improvement.Methods: This was a cross-sectional comparative study. One hundred and nine adolescents aged 15-20 years clinically examined for facial acne vulgaris. Quality of life before and after 6 weeks of treatment with 10% benzoyl peroxide was assessed using the Cardiff acne disability index. Data was analyzed using SPSS 16. The differences in quality of life scores were tested using non-parametric tests. Level of significance of all tests was p<0.05.Results: Post-treatment, the median CADI score improved to 2 from a pre-interventional score of 4, p<0.001. Improvement was observed in all the components of the CADI especially with the question, “how bad do you think your acne is now” with a percentage reduction from 81.4% to 54.6% and this improvement was in more males with improvement from 92% to 65%. Also, post-treatment, moderate to severe clinical severity of acne improved from 49.1% to 10.3%, p<0.001.Conclusions: Treatment of adolescent facial acne leads to improvement of QOL especially in the perception of facial skin appearance and the severity of acne.

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Munichandrappa, Prathima, Manjunath K. G., Kiran C., and Anirudh Variyar. "A comparative study of insulin resistance in acne vulgaris." International Journal of Research in Dermatology 3, no. 3 (August 24, 2017): 403. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20172545.

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Background: Acne is common skin problem among adolescents and young adults. Recently the role of insulin resistance in acne is being widely researched.The objectives of the study were to evaluate insulin resistance in acne, to compare the insulin resistance among cases and controls using homeostasis model assessment of insulin resistanceMethods: 45 cases and 45 controls were recruited. Acne severity was graded using the global acne grading system(GAGS). Fasting glucose, fasting insulin levels were done and insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR).Results: We did not find any statistically significant difference in fasting insulin levels between cases and controls. However, a weak positive correlation between acne severity and fasting insulin levels (r =0.3, p=0.04) were observed. Fasting glucose levels and HOMA-IR values observed between cases and controls were not statistically significant (p=0.05, p=0.59 respectively). Conclusions: Our study did not suggest a major role of insulin resistance in acne.

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Ballanger, Fabienne, Nicole Auffret, Marie-Thérèse Leccia, Jean Paul Claudel, and Brigitte Dréno. "Acneiform Lesions but not Acne after Treatment with Janus Kinase Inhibitors: Diagnosis and Management of Janus Kinase-acne." Acta Dermato-Venereologica 103 (June 22, 2023): adv11657. http://dx.doi.org/10.2340/actadv.v103.11657.

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Yang, Jieqiong, and Panzhu Luo. "Study on the spatial correlation network structure of agricultural carbon emission efficiency in China." Electronic Research Archive 31, no. 12 (2023): 7256–83. http://dx.doi.org/10.3934/era.2023368.

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<abstract> Achieving carbon neutrality requires high efficiency in agricultural carbon emissions. This study employs a super efficiency Slack Based Measure-Data Envelopment Analysis (SBM-DEA) model to measure the Agricultural Carbon Emission Efficiency (ACEE) of 31 provinces, cities, and autonomous regions within the Chinese Mainland from 2001 to 2021. Additionally, it utilizes the modified gravity model and a social network analysis to establish the spatial correlation relationship of ACEE, and extensively investigates the characteristics and transmission mechanism of China's spatial correlation network structure regarding ACEE. The findings reveal the following: 1) The spatial correlation relationship of China's ACEE from 2001 to 2021 exhibits a complex network structure; 2) in terms of the overall network structure characteristics of the spatial correlation, the ACEE network demonstrates a high degree of correlation and displays a stable temporal evolution trend; 3) concerning the centrality network structure characteristics of the spatial correlation, most provinces in China experience a continuous decline in point centrality and near centrality, while the interdependence of the ACEE between provinces increases; and 4) regarding the clustering characteristics of the spatial correlation, variations exist in the correlation among the four plates of the ACEE. However, they mostly assume a mediating role, and in 2021, the ACEE network sectors witnessed a robust interoperability. </abstract>

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Geng, Ryan, and R. Gary Sibbald. "Acne Vulgaris: Clinical Aspects and Treatments." Advances in Skin & Wound Care 37, no. 2 (February 2024): 67–75. http://dx.doi.org/10.1097/asw.0000000000000089.

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ABSTRACT Acne vulgaris is a common chronic skin condition characterized by variable combinations of papules, pustules, cysts, and nodules that invariably arise from comedones. This article focuses on the clinical presentation of acne vulgaris subtypes and treatment options. Other related topics discussed include epidemiology and differential diagnoses. GENERAL PURPOSE To review the clinical presentation and treatment of acne vulgaris. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant will: 1. Identify a differential diagnosis of acne vulgaris. 2. Recognize clinical feature of various acne vulgaris subtypes. 3. Specify epidemiologic characteristics of acne vulgaris. 4. Select topical, systemic, and nonpharmaceutical treatment options for a patient with acne vulgaris.

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Ogorelica, Dejan, Zorica Gajinov, Ljubinka Matović, Branislava Gajić, Zoran Golušin, and Sanja Jakovljević. "Acne Keloidalis Nuchae – Case Report." Serbian Journal of Dermatology and Venereology 11, no. 3 (September 1, 2019): 85–88. http://dx.doi.org/10.2478/sjdv-2019-0012.

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Abstract Acne keloidalis nuchae (AKN) / folliculitis keloidalis nuchae (FKN) is a chronic inflammatory condition which involves hair follicles localized predominantly in occipital scalp and posterior neck area leading to hypertrophic scarring alopecia. We present a 59-year-old factory worker, Caucasian male with a whitish alopecic oval plaque about 10 cm in diameter in the occipital region. The peripheral part of plaque was mildly inflammated, with groups of tufted terminal hairs, while the central part showed cicatricial alopecia and discrete non-adherent dry scales. Skin changes firstly occurred 6 years earlier, as itchy papules and pustules that sometimes healed with scarring. The applied relevant diagnostic and therapeutical measures are discussed in this report.

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Subotić, Milica, and Verica Đuran. "Treatment of acne vulgaris: a literature review / Lečenje običnih akni (acne vulgaris) – pregled literature." Serbian Journal of Dermatology and Venerology 2, no. 1 (January 1, 2010): 13–20. http://dx.doi.org/10.2478/v10249-011-0018-8.

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Abstract Acne vulgaris is a common skin disease, which affects individuals of all races and ages. In Caucasians, almost 85% of individuals between 12 and 25 years, as well as 25% of adults, are affected with some forms of acne. The pathophysiology of acne is multifactorial, and thus, the treatment must cover all the possible causes of acne. For this reason, acne therapy is mostly a combination therapy, with the main goal to achieve clinical improvement, without scarring and residuals, as much as possible. The treatment should be planned individually, depending on the clinical appearance, severity and psychological profile of the patient. The treatment usually takes time and requires dedication and patience of both the patient and the physician.

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Numata, Takahiro, Kenji Sugita, Arifa Ahamed Rahman, and Abidur Rahman. "Actin isovariant ACT7 controls root meristem development in Arabidopsis through modulating auxin and ethylene responses." Journal of Experimental Botany, June 24, 2022. http://dx.doi.org/10.1093/jxb/erac280.

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Abstract Meristem is the most functionally dynamic part in a plant body. The shaping of the meristem requires constant cell division and cell elongation, which are influenced by hormones and cell cytoskeletal component, actin. Although the roles of hormones in modulating meristem development have been extensively studied, the role of actin in this process is still elusive. Using the single and double mutants of the vegetative class actin, we demonstrate that actin isovariant ACT7 plays an important role in root meristem development. In absence of ACT7, but not ACT8 and ACT2, depolymerization of actin was observed. Consistently, act7 mutant showed reduced cell division, cell elongation, and meristem length. Intracellular distribution and trafficking of auxin transport proteins in the actin mutants revealed that ACT7 specifically functions in root meristem to facilitate the trafficking of auxin efflux carriers PIN1 and PIN2, and consequently the transport of auxin. Compared with act7, act7act8 double mutant shows slightly enhanced phenotypic response and altered intracellular trafficking. The altered distribution of auxin in act7 and act7act8 affects the response of the roots to ethylene but not to cytokinin. Collectively, our results suggest that ACT7 dependent auxin-ethylene response plays a key role in controlling Arabidopsis root meristem development.

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Quintero, Wendy Lorena, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko, and Liliana Torcoroma García. "Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)." BMC Complementary Medicine and Therapies 21, no. 1 (July 2, 2021). http://dx.doi.org/10.1186/s12906-021-03347-6.

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Abstract Background Parasite persistence, exacerbated and sustained immune response, and continuous oxidative stress have been described to contribute to the development of the cardiac manifestations in Chronic Chagas Disease. Nevertheless, there are no efficient therapies to resolve the Trypanosoma cruzi infection and prevent the disease progression. Interestingly, trypanocide, antioxidant, and immunodulatory properties have been reported separately for some major terpenes, as citral (neral plus geranial), limonene, and caryophyllene oxide, presents in essential oils (EO) extracted from two chemotypes (Citral and Carvone) of Lippia alba. The aim of this study was to obtain L. alba essential oil fractions enriched with the aforementioned bioactive terpenes and to evaluate the impact of these therapies on trypanocide, oxidative stress, mitochondrial bioenergetics, genotoxicity, and inflammatory markers on T. cruzi-infected macrophages. Methods T. cruzi-infected J774A.1 macrophage were treated with limonene-enriched (ACT1) and citral/caryophyllene oxide-enriched (ACT2) essential oils fractions derived from Carvone and Citral-L. alba chemotypes, respectively. Results ACT1 (IC50 = 45 ± 1.7 μg/mL) and ACT2 (IC50 = 80 ± 1.9 μg/mL) exhibit similar trypanocidal effects to Benznidazole (BZN) (IC50 = 48 ± 2.5 μg/mL), against amastigotes. Synergistic antiparasitic activity was observed when ACT1 was combined with BZN (∑FIC = 0.52 ± 0.13 μg/mL) or ACT2 (∑FIC = 0.46 ± 1.7 μg/mL). ACT1 also decreased the oxidative stress, mitochondrial metabolism, and genotoxicity of the therapies. The ACT1 + ACT2 and ACT1 + BZN experimental treatments reduced the pro-inflammatory cytokines (IFN-γ, IL-2, and TNF-α) and increased the anti-inflammatory cytokines (IL-4 and IL-10). Conclusion Due to its highly trypanocidal and immunomodulatory properties, ACT1 (whether alone or in combination with BZN or ACT2) represents a promising L. alba essential oil fraction for further studies in drug development towards the Chagas disease control.

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Ledoux, Emily A., Alana Gudelsky, Claire C. Tseng, Jasbir Seehra, and Jennifer L. Lachey. "Abstract P321: <RKER-012, A Novel Activin Receptor Type Ilb (actrllb) Ligand Trap, Inhibited Mediators Of Dysregulated Vascular Remodeling In Pulmonary Arterial Endothelial And Smooth Muscle Cells>." Hypertension 80, Suppl_1 (September 2023). http://dx.doi.org/10.1161/hyp.80.suppl_1.p321.

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Rationale: Imbalance in TGF-β signaling molecules SMAD2/3 and SMAD1/5/9 is a key driver of vascular dysfunction and pulmonary arterial hypertension (PAH) pathophysiology. KER-012, a novel ActRIIB ligand trap, designed to bind activin (Act) A and ActB to inhibit SMAD2/3: thereby permitting bone morphogenic protein (BMP) ligand signaling via SMAD1/5/9 to potentially rebalance TGF-β signaling and restore vascular homeostasis in PAH and associated disorders. Methods: Using hypoxia (1% O2) to mimic the pulmonary cell environment of PAH, we evaluated the effect of KER-012 or RKER -012 (a research form of KER-012) on TGF-β signaling in human pulmonary arterial endothelial cells (HPAECs) and smooth muscle cells (HPASMCs), two key cell types involved in the vascular remodeling in PAH. Gene expression of hypoxia/normoxia cultured cells was assessed by qPCR, phosphorylation of SMAD2 (pSMAD2) by alphaLISA, and ActA protein levels by ELISA. Results: HPAECs and HPASMCs both responded to TGF-β ligands implicated in PAH. ActA and Growth Differentiation Factor (GDF)11 increased SMAD2 phosphorylation and BMP9 increased SMAD1 phosphorylation (pSMAD1), confirming activation of the respective signaling pathways. KER-012 inhibited ActA and GDF11 induced pSMAD2, but not BMP9 induced pSMAD1. In hypoxic HPAECs, ActA gene expression increased >3-fold and BMPR2 expression decreased >2-fold relative to normoxia. ActA protein levels from hypoxic HPAEC supernatant also increased 10-fold, which was associated with an observed increase in pSMAD2 activation. While RKER-012 did not affect ActA gene expression, it did reduce ActA protein levels in supernatant to normoxic levels. This reduction in ActA may represent the fraction not bound to RKER-012, and potentially demonstrates a reduction in ActA availability for SMAD2/3 activation. Conclusions: ActA inhibition by RKER-012 restored homeostatic SMAD2 signaling in HPAECs and HPASMCs in an in vitr o PAH hypoxia model. RKER012 has also shown not to effect BMP signaling in these cells. These studies suggest that RKER-012 can potentially correct imbalanced SMAD signaling in PAH, partially via binding and inhibition of ActA protein.

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48

"Abstracts: XV Acta Endocrinologica Congress." Acta Endocrinologica 110, no. 3_Suppl (August 1985): S11—S201. http://dx.doi.org/10.1530/acta.0.109s0011.

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49

Collard, Damien. "De la procédure in abstracto à la procédure « en acte »." Activites 07, no. 1 (April 15, 2010). http://dx.doi.org/10.4000/activites.2334.

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50

"Abstract of Acta Geologica Sinica (Chinese Edition)." Acta Geologica Sinica - English Edition 72, no. 4 (September 7, 2010): 466–69. http://dx.doi.org/10.1111/j.1755-6724.1998.tb00424.x.

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Journal articles on the topic 'Acte abstrait'

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