Journal articles: 'Acoustic drug delivery'

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Pawar, Pankaj P., and Dipti G. Phadtare. "Acoustic Mediated Drug Delivery System." Research Journal of Pharmaceutical Dosage Forms and Technology 8, no. 1 (2016): 55. http://dx.doi.org/10.5958/0975-4377.2016.00008.2.

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Pourmehran, Oveis, Maziar Arjomandi, Benjamin Cazzolato, Zhao Tian, Sarah Vreugde, Shari Javadiyan, Alkis J. Psaltis, and Peter-John Wormald. "Acoustic drug delivery to the maxillary sinus." International Journal of Pharmaceutics 606 (September 2021): 120927. http://dx.doi.org/10.1016/j.ijpharm.2021.120927.

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Lewis, George, William Olbricht, and George Lewis. "Acoustic targeted drug delivery in neurological tissue." Journal of the Acoustical Society of America 122, no. 5 (2007): 3007. http://dx.doi.org/10.1121/1.2942740.

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Masterson, Jack, Brett Kluge, Aaron Burdette, and George Lewis Sr. "Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis." Therapeutic Delivery 11, no. 6 (June 2020): 363–72. http://dx.doi.org/10.4155/tde-2020-0009.

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Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Materials & methods: A commercially available, sustained acoustic medicine (sam®) ultrasound device providing 4 h, 1.3 W, 132 mW/cm2, 3 MHz ultrasound treatment was evaluated for increasing the drug delivery of diclofenac gel through a human skin model and was compared with standard of care topical control diclofenac gel. Results: Sonophoresis of the diclofenac gel for 4 h increases diclofenac delivery by 3.8× (p < 0.01), and penetration by 32% (p < 0.01). Conclusion: Sustained acoustic medicine can be used as a transdermal drug-delivery device for nonsteroidal anti-inflammatory drugs.

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Hu, Mengyi, Xuemei Ge, Xuan Chen, Wenwei Mao, Xiuping Qian, and Wei-En Yuan. "Micro/Nanorobot: A Promising Targeted Drug Delivery System." Pharmaceutics 12, no. 7 (July 15, 2020): 665. http://dx.doi.org/10.3390/pharmaceutics12070665.

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Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reach the target, the designed micro/nanorobots can move autonomously, which makes it possible to deliver drugs to the hard-to-reach areas. Micro/nanorobots were driven by exogenous power (magnetic fields, light energy, acoustic fields, electric fields, etc.) or endogenous power (chemical reaction energy). Cell-based micro/nanorobots and DNA origami without autonomous movement ability were also introduced in this article. Although micro/nanorobots have excellent prospects, the current research is mainly based on in vitro experiments; in vivo research is still in its infancy. Further biological experiments are required to verify in vivo drug delivery effects of micro/nanorobots. This paper mainly discusses the research status, challenges, and future development of micro/nanorobots.

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Allen, John S. "Acoustic fields and forces in drug delivery applications." Journal of the Acoustical Society of America 144, no. 3 (September 2018): 1750. http://dx.doi.org/10.1121/1.5067755.

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Nie, Luzhen, Sevan Harput, James R. McLaughlan, David Cowell, Thomas Carpenter, and Steven Freear. "Acoustic microbubble trapping for enhanced targeted drug delivery." Journal of the Acoustical Society of America 141, no. 5 (May 2017): 4012. http://dx.doi.org/10.1121/1.4989218.

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Anosov, A. A., O. Yu Nemchenko, Yu A. Less, A. S. Kazanskii, and A. D. Mansfel’d. "Possibilities of acoustic thermometry for controlling targeted drug delivery." Acoustical Physics 61, no. 4 (July 2015): 488–93. http://dx.doi.org/10.1134/s1063771015040028.

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Park, E. J., K. I. Jung, and S. W. Yoon. "Acoustic mechanisms as an enhancer for transdermal drug delivery." Journal of the Acoustical Society of America 107, no. 5 (May 2000): 2788. http://dx.doi.org/10.1121/1.428968.

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Kooiman, Klazina, Hendrik J. Vos, Michel Versluis, and Nico de Jong. "Acoustic behavior of microbubbles and implications for drug delivery." Advanced Drug Delivery Reviews 72 (June 2014): 28–48. http://dx.doi.org/10.1016/j.addr.2014.03.003.

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Raina, Deepika, Siddharth Singh, Rohit Singh Negi, and Bunty Sharma. "An Approach for Drug Delivery to the Brain Via External Acoustic Meatus." ECS Transactions 107, no. 1 (April 24, 2022): 3609–18. http://dx.doi.org/10.1149/10701.3609ecst.

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Depression is momentous mood chaos marked by a mixture of symptoms that interfere with a person’s daily activities. The oral administration serves dose dumping issues of therapeutic molecules in specially targeted delivery. So, the external auditory canal pathway was explored to deliver the API and it help to bypass the above-mentioned problem. Sonication bath method was used to prepare bio-nanosuspension loaded with escitalopram and biopolymer extracted from Tagetes patula. Different ratios of drug and biopolymer were considered and 10 formulations were formulated followed by evaluation parameters like SEM, FTIR for biopolymer and ex-vivo, stability, drug release studies, etc., for the final formulation was performed. Formulations were examined through many evaluation parameters, such as content uniformity, pH, in-vitro drug release, and many more. It was found that STP 1 (1:0.5) was the best formulation. From pharmacokinetic data and in-vitro studies revealed and concluded that acoustic meatus is a feasible pathway for molecules delivery to the brain for depression treatment.

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Cho, Jung-Ah, Bong Jik Kim, Yu-Jung Hwang, Shin-Wook Woo, Tae-Soo Noh, and Myung-Whan Suh. "Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-co-glycolide Microcapsule Vehicle in Intratympanic Drug Delivery for Treating Acute Acoustic Trauma." International Journal of Molecular Sciences 22, no. 11 (May 27, 2021): 5720. http://dx.doi.org/10.3390/ijms22115720.

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The treatment of acute hearing loss is clinically challenging due to the low efficacy of drug delivery into the inner ear. Local intratympanic administration of dexamethasone (D) and insulin-like growth factor 1 (IGF1) has been proposed for treatment, but they do not persist in the middle ear because they are typically delivered in fluid form. We developed a dual-vehicle drug delivery system consisting of cross-linked hyaluronic acid and polylactide-co-glycolide microcapsules. The effect and biocompatibility of the dual vehicle in delivering D and IGF1 were evaluated using an animal model of acute acoustic trauma. The dual vehicle persisted 10.9 times longer (8.7 days) in the middle ear compared with the control (standard-of-care vehicle, 0.8 days). The dual vehicle was able to sustain drug release over up to 1 to 2 months when indocyanine green was loaded as the drug. One-third of the animals experienced an inflammatory adverse reaction. However, it was transient with no sequelae, which was validated by micro CT findings, endoscopic examination, and histological assessment. Hearing restoration after acoustic trauma was satisfactory in both groups, which was further supported by comparable numbers of viable hair cells. Overall, the use of a dual vehicle for intratympanic D and IGF1 delivery may maximize the effect of drug delivery to the target organ because the residence time of the vehicle is prolonged.

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Omeh, Romanus Chijioke, Mercy Ebere Ugwueze, Raymond Ogbonna Offiah, Chukwuemeka Christian Mbah, Audu Mumuni Momoh, Ikechukwu Virgilus Onyishi, Godswill Chukwuemeka Onunkwo, and Jacob Okechukwu Onyechi. "Oral drug delivery: Gastrointestinal tract adaptations, barriers and strategies for delivery enhancement - a review." Bio-Research 20, no. 3 (October 16, 2022): 1685–98. http://dx.doi.org/10.4314/br.v20i3.6.

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The mouth is a vital route of drug administration with over 84 % of all medicines reportedly administered through it. The gastrointestinal system is equally imbued with a lot of adaptive features that make the oral route even more conducive for systemic drug delivery. The usefulness of the oral route is, however challenged by the existence of numerous absorption barriers which limit the effective absorption and delivery of drugs to their target sites in the body systems. Understanding these adaptive attributes, systemic barriers and available strategies for overcoming such barriers will not only be helpful in drug development and design but also useful to the formulation scientists desirous of optimizing drug delivery. The objective of this work was to review the gastrointestinal route of drug administration with respect to some biochemical and physio-anatomic features that impede or enhance drug absorption and to highlight current strategies that have been deployed to achieve optimum per oral drug delivery. The current review reveals the emerging roles of nanocarriers in oral drug delivery. Polymeric nanocarriers enhance the solubility, targeting and safety profiles of many important pharmacological agents. Novel systems that offer protection against gastro enzymes and as such, promote oral administration of biologicals are being widely investigated. Mechanical, magnetic, and acoustic energy – induced membrane perturbation are other delivery options receiving research attentions. It may be concluded that, with the avalanche of research efforts in the area, the oral route will maintain its prominence among other routes of drug administration.

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Omeh, Romanus Chijioke, Mercy Ebere Ugwueze, Raymond Ogbonna Offiah, Chukwuemeka Christian Mbah, Audu Mumuni Momoh, Ikechukwu Virgilus Onyishi, Godswill Chukwuemeka Onunkwo, and Jacob Okechukwu Onyechi. "Oral drug delivery: Gastrointestinal tract adaptations, barriers and strategies for delivery enhancement - a review." Bio-Research 20, no. 3 (October 16, 2022): 1685–98. http://dx.doi.org/10.4314/br.v20i3.

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The mouth is a vital route of drug administration with over 84 % of all medicines reportedly administered through it. The gastrointestinal system is equally imbued with a lot of adaptive features that make the oral route even more conducive for systemic drug delivery. The usefulness of the oral route is, however challenged by the existence of numerous absorption barriers which limit the effective absorption and delivery of drugs to their target sites in the body systems. Understanding these adaptive attributes, systemic barriers and available strategies for overcoming such barriers will not only be helpful in drug development and design but also useful to the formulation scientists desirous of optimizing drug delivery. The objective of this work was to review the gastrointestinal route of drug administration with respect to some biochemical and physio-anatomic features that impede or enhance drug absorption and to highlight current strategies that have been deployed to achieve optimum per oral drug delivery. The current review reveals the emerging roles of nanocarriers in oral drug delivery. Polymeric nanocarriers enhance the solubility, targeting and safety profiles of many important pharmacological agents. Novel systems that offer protection against gastro enzymes and as such, promote oral administration of biologicals are being widely investigated. Mechanical, magnetic, and acoustic energy – induced membrane perturbation are other delivery options receiving research attentions. It may be concluded that, with the avalanche of research efforts in the area, the oral route will maintain its prominence among other routes of drug administration.

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Leclerc, Lara, Nathalie Prévôt, Sophie Hodin, Xavier Delavenne, Heribert Mentzel, Uwe Schuschnig, and Jérémie Pourchez. "Acoustic Aerosol Delivery: Assessing of Various Nasal Delivery Techniques and Medical Devices on Intrasinus Drug Deposition." Pharmaceuticals 16, no. 2 (January 17, 2023): 135. http://dx.doi.org/10.3390/ph16020135.

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This study aims to evaluate the impact of the nasal delivery technique and nebulizing technologies (using different frequencies of oscillating airflow) for acoustic aerosol targeting of maxillary sinuses. Sodium fluoride (chemical used as a marker), tobramycin (drug used as a marker) and 99mTc-DTPA (radiolabel aerosol) were used to assess the intrasinus aerosol deposition on a nasal cast. Two commercial medical devices (PARI SINUS nebulizer and NL11SN ATOMISOR nebulizer) and various nasal delivery techniques (one or two nostrils connected to the aerosol inlet, the patient with the soft palate closed or open during the acoustic administration of the drug, the presence or not of flow resistance in the nostril opposite to the one allowing the aerosol to be administered) were evaluated. The closed soft palate condition showed a significant increase in drug deposition even though no significant difference in the rest of the nasal fossae was noticed. Our results clearly demonstrated a higher intrasinus aerosol deposition (by a factor 2–3; respectively 0.03 ± 0.007% vs. 0.003 ± 0.0002% in the right maxillary sinus and 0.027 ± 0.006% vs. 0.013 ± 0.004% in the left maxillary sinus) using the acoustic airflow generated by the PARI SINUS compared to the NL11SN ATOMISOR. The results clearly demonstrated that the optimal conditions for aerosol deposition in the maxillary sinuses were obtained with a closed soft palate. Thus, the choice of the nebulizing technology (and mainly the frequency of the pulsating aerosol generated) and also the recommendation of the best nasal delivery technique are key factors to improve intrasinus aerosol deposition.

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Paverd, Catherine, Erasmia Lyka, Delphine Elbes, and Constantin Coussios. "Passive acoustic mapping of extravasation following ultrasound-enhanced drug delivery." Physics in Medicine & Biology 64, no. 4 (February 6, 2019): 045006. http://dx.doi.org/10.1088/1361-6560/aafcc1.

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Fan, Ching-Hsiang, Ya-Hsuan Lee, Yi-Ju Ho, Chung-Hsin Wang, Shih-Tsung Kang, and Chih-Kuang Yeh. "Macrophages as Drug Delivery Carriers for Acoustic Phase-Change Droplets." Ultrasound in Medicine & Biology 44, no. 7 (July 2018): 1468–81. http://dx.doi.org/10.1016/j.ultrasmedbio.2018.03.009.

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Pourmehran, Oveis, Benjamin Cazzolato, Zhao Tian, and Maziar Arjomandi. "Acoustically-driven drug delivery to maxillary sinuses: Aero-acoustic analysis." European Journal of Pharmaceutical Sciences 151 (August 2020): 105398. http://dx.doi.org/10.1016/j.ejps.2020.105398.

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Rapoport, Natalya, and William G. Pitt. "Stabilization and acoustic activation of polymeric micelles for drug delivery." Journal of the Acoustical Society of America 115, no. 4 (2004): 1406. http://dx.doi.org/10.1121/1.1738301.

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Raina, D., and N. V. Satheesh Madhav. "A SMART APPROACH FOR FORMULATION PROCESS OF ESCITALOPRAM LOADED BIO-NANO SUSPENSION FOR BRAIN DELIVERY VIA NOVELISTIC EAM (EXTERNAL ACOUSTIC MEATUS) PLATFORM." INDIAN DRUGS 54, no. 08 (August 28, 2017): 81–84. http://dx.doi.org/10.53879/id.54.08.10875.

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Our aim was to target antidepressant drug loaded nano-suspension using novel bioexcepient isolated from kernels of Prunus amygdalus and explore the capability of external acoustic meatus as novel acoustic drug delivery system. We isolated the biomaterial and performed various physicochemical evaluations along with spectral analysis including UV, IR, Mass, NMR, SEM. The bio-nano suspension formulated with the novel bioexcepient was tested for its functional properties. Eight formulations of escitalopram were prepared by using biomaterial as a retardant cum stabilizer and glycerin as nanosizent. All formulations were subjected to various evaluations, including pH, dispersibility, entrapment efficiency, particle size, mucoadhesion, in vitro release and stability. Our results revealed that the biopolymer possess promising retardibility cum stability and mucoadhesivity. Based on the in vitro and pharmacodynamic results obtained, it can be concluded that significant amount of drug reaches to the brain via external acoustic meatus and so it is feasible to deliver antidepressant molecule by this novelistic route.

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Zhao, Qingying, Min Li, Jun Luo, Hanqing Wang, and Jinge Cao. "Approaching Tumor Tissue in Local Blood Vessel for Targeted Drug Delivery by Nanorobots." Journal of Computational and Theoretical Nanoscience 13, no. 10 (October 1, 2016): 6654–61. http://dx.doi.org/10.1166/jctn.2016.5611.

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This paper describes a nanorobot control algorithm designed for approaching tumor tissue in local blood vessel for targeted drug delivery. The algorithm coordinates nanorobots’ movements through use of two types of chemical molecules, an acoustic signal and velocity characteristic of blood fluid. After detecting the chemical molecules released by cancer cells, a nanorobot moves toward the area of higher concentration of the molecule and releases another chemical molecule which alerts others to aggregate to the target. When nanorobots detect acoustic signals emitted by nanorobots reaching target, their paths will be planned according to intensity of acoustic signals and velocity characteristic of blood fluid. The simulations show that compared with the existed approaches, the proposed algorithm results in an increase of nanorobots’ population and a decrease of cost time to reach target site with the help of acoustic signals and velocity characteristic. As a whole, the results obtained suggest that the algorithm presented in this paper is a better strategy for approaching tumor tissue in local blood vessel by nanorobots.

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Osei, Ernest, and Aladdin Al-Asady. "A review of ultrasound-mediated microbubbles technology for cancer therapy: a vehicle for chemotherapeutic drug delivery." Journal of Radiotherapy in Practice 19, no. 3 (August 22, 2019): 291–98. http://dx.doi.org/10.1017/s1460396919000633.

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AbstractBackground:The unique behaviour of microbubbles under ultrasound acoustic pressure makes them useful agents for drug and gene delivery. Several studies have demonstrated the potential application of microbubbles as a non-invasive, safe and effective technique for targeted delivery of drugs and genes. The drugs can be incorporated into the microbubbles in several different approaches and then carried to the site of interest where it can be released by destruction of the microbubbles using ultrasound to achieve the required therapeutic effect.Methods:The objective of this article is to report on a review of the recent advances of ultrasound-mediated microbubbles as a vehicle for delivering drugs and genes and its potential application for the treatment of cancer.Conclusion:Ultrasound-mediated microbubble technology has the potential to significantly improve chemotherapy drug delivery to treatment sites with minimal side effects. Moreover, the technology can induce temporary and reversible changes in the permeability of cells and vessels, thereby allowing for drug delivery in a spatially localised region which can improve the efficiency of drugs with poor bioavailability due to their poor absorption, rapid metabolism and rapid systemic elimination.

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Cao, Hiep Xuan, Daewon Jung, Han-Sol Lee, Van Du Nguyen, Eunpyo Choi, Byungjeon Kang, Jong-Oh Park, and Chang-Sei Kim. "Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery." Pharmaceutics 14, no. 7 (July 18, 2022): 1490. http://dx.doi.org/10.3390/pharmaceutics14071490.

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Acoustic tweezers provide unique capabilities in medical applications, such as contactless manipulation of small objects (e.g., cells, compounds or living things), from nanometer-sized extracellular vesicles to centimeter-scale structures. Additionally, they are capable of being transmitted through the skin to trap and manipulate drug carriers in various media. However, these capabilities are hindered by the limitation of controllable degrees of freedom (DoFs) or are limited maneuverability. In this study, we explore the potential application of acoustical tweezers by presenting a five-DoF contactless manipulation acoustic system (AcoMan). The system has 30 ultrasound transducers (UTs) with single-side arrangement that generates active traveling waves to control the position and orientation of a fully untethered nanocarrier clusters (NCs) in a spherical workspace in water capable of three DoFs translation and two DoFs rotation. In this method, we use a phase modulation algorithm to independently control the phase signal for 30 UTs and manipulate the NCs’ positions. Phase modulation and switching power supply for each UT are employed to rotate the NCs in the horizontal plane and control the amplitude of power supply to each UT to rotate the NCs in the vertical plane. The feasibility of the method is demonstrated by in vitro and ex vivo experiments using porcine ribs. A significant portion of this study could advance the therapeutic application such a system as targeted drug delivery.

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Hiltl, Pia-Theresa, Michael Fink, Stefan J. Rupitsch, Geoffrey Lee, and Helmut Ermert. "Development of sonosensitive Poly-(L)-lactic acid nanoparticles." Current Directions in Biomedical Engineering 3, no. 2 (September 7, 2017): 679–82. http://dx.doi.org/10.1515/cdbme-2017-0143.

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AbstractDue to serious side effects of traditional chemotherapeutic treatment, novel treatment techniques like targeted drug delivery, which allows a reduction of the overall dosage of drugs, are investigated. It is worth mentioning that at the same time, precise drug delivery offers an increased dosage of chemotherapeutic drugs in the tumorous area employing the EPR effect. Therefore, vehicles smaller than 400 nm can be used to pass the poorly aligned endothelial cells of tumour vessels passively through their fenestrations. In a subsequent step, the chemotherapeutic drugs need to be released. One possibility is an ultrasound-based release via inertial cavitation. Thereby, it is desirable to restrict the drug release to a narrow range. Thus, the cavitation inducing ultrasound wave has to be focused to that region of interest. Ultrasound frequencies of more than 500 kHz enable sufficient focusing, however, inertial cavitation occurs primarily at much lower frequencies. In order to afford inertial cavitation at 500 kHz, either bigger particles in the range of micrometres are needed as cavitation nucleus, which is not possible due to the EPR effect or high acoustic pressure is needed to generate inertial cavitation. Nevertheless, this high pressure is inappropriate for clinical applications due to thermal and mechanical effects on biological tissue.We have produced Poly-(L)-lactic acid (PLLA) nanoparticles by a solvent evaporation technique that serve as nucleus for inertial cavitation at moderate acoustic pressure of 800 kPa and at high frequencies of 800 kHz after the particles have been freeze-dried. In this contribution, we characterize the designed particles and present the production process. Moreover, we show that these particles enable inertial cavitation at an acoustic pressure and at acoustic frequencies which are commonly used in clinical ultrasound units. We also show that other particles with the same size at the same acoustic parameters do not induce cavitation activity.

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Ahmed, Salma E., Nahid Awad, Vinod Paul, Hesham G. Moussa, and Ghaleb A. Husseini. "Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release." Current Topics in Medicinal Chemistry 18, no. 10 (August 6, 2018): 857–80. http://dx.doi.org/10.2174/1568026618666180608125344.

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Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

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Stewart, Fraser, Yongqiang Qiu, Holly Lay, Ian Newton, Benjamin Cox, Mohammed Al-Rawhani, James Beeley, et al. "Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy." Sensors 17, no. 7 (July 3, 2017): 1553. http://dx.doi.org/10.3390/s17071553.

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Nguyen, A., P. Lewin, and S. Wrenn. "Strategies for increasing acoustic susceptibility of liposomes for controlled drug delivery." Bubble Science, Engineering & Technology 5, no. 1-2 (July 2014): 25–31. http://dx.doi.org/10.1179/1758897914y.0000000012.

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Rajapaksa, Anushi, Aisha Qi, Leslie Y. Yeo, Ross Coppel, and James R. Friend. "Enabling practical surface acoustic wave nebulizer drug delivery via amplitude modulation." Lab Chip 14, no. 11 (2014): 1858–65. http://dx.doi.org/10.1039/c4lc00232f.

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Yang, Ye, Teng Ma, Sinan Li, Qi Zhang, Jiqing Huang, Yifei Liu, Jianwei Zhuang, et al. "Self-Navigated 3D Acoustic Tweezers in Complex Media Based on Time Reversal." Research 2021 (January 4, 2021): 1–13. http://dx.doi.org/10.34133/2021/9781394.

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Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media. However, the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation. In this study, we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images, thereby enabling acoustic manipulation in nontransparent media. Furthermore, we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps. We achieved 3D particle manipulation in heterogeneous media (through resin baffle and ex vivo macaque and human skulls) by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves. Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery, controlled micromachine transfer, and precise treatment.

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Honari, Arvin, Darrah A. Merillat, Aditi Bellary, Mohammadaref Ghaderi, and Shashank R. Sirsi. "Improving Release of Liposome-Encapsulated Drugs with Focused Ultrasound and Vaporizable Droplet-Liposome Nanoclusters." Pharmaceutics 13, no. 5 (April 22, 2021): 609. http://dx.doi.org/10.3390/pharmaceutics13050609.

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Active targeted delivery of small molecule drugs is becoming increasingly important in personalized therapies, especially in cancer, brain disorders, and a wide variety of other diseases. However, effective means of spatial targeting and delivering high drug payloads in vivo are still lacking. Focused ultrasound combined with superheated phase-shift nanodroplets, which vaporize into microbubbles using heat and sound, are rapidly becoming a popular strategy for targeted drug delivery. Focused ultrasound can target deep tissue with excellent spatial precision and without using ionizing energy, thus can activate nanodroplets in circulation. One of the main limitations of this technology has been poor drug loading in the droplet core or the shell material. To address this need, we have developed a strategy to combine low-boiling point decafluorabutane and octafluoropropane (DFB and OFP) nanodroplets with drug-loaded liposomes, creating phase-changeable droplet-liposome clusters (PDLCs). We demonstrate a facile method of assembling submicron PDLCs with high drug-loading capacity on the droplet surface. Furthermore, we demonstrate that chemical tethering of liposomes in PDLCs enables a rapid release of their encapsulated cargo upon acoustic activation (>60% using OFP-based PDLCs). Rapid uncaging of small molecule drugs would make them immediately bioavailable in target tissue or promote better penetration in local tissue following intravascular release. PDLCs developed in this study can be used to deliver a wide variety of liposome-encapsulated therapeutics or imaging agents for multi-modal imaging applications. We also outline a strategy to deliver a surrogate encapsulated drug, fluorescein, to tumors in vivo using focused ultrasound energy and PDLCs.

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Xiao, Yaxuan, Jinhua Zhang, Bin Fang, Xiong Zhao, and Nanjing Hao. "Acoustics-Actuated Microrobots." Micromachines 13, no. 3 (March 20, 2022): 481. http://dx.doi.org/10.3390/mi13030481.

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Microrobots can operate in tiny areas that traditional bulk robots cannot reach. The combination of acoustic actuation with microrobots extensively expands the application areas of microrobots due to their desirable miniaturization, flexibility, and biocompatibility features. Herein, an overview of the research and development of acoustics-actuated microrobots is provided. We first introduce the currently established manufacturing methods (3D printing and photolithography). Then, according to their different working principles, we divide acoustics-actuated microrobots into three categories including bubble propulsion, sharp-edge propulsion, and in-situ microrotor. Next, we summarize their established applications from targeted drug delivery to microfluidics operation to microsurgery. Finally, we illustrate current challenges and future perspectives to guide research in this field. This work not only gives a comprehensive overview of the latest technology of acoustics-actuated microrobots, but also provides an in-depth understanding of acoustic actuation for inspiring the next generation of advanced robotic devices.

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Zhang, Li, Shiyu Zhang, Huajian Chen, Yu Liang, Bingxia Zhao, Wanxian Luo, Qian Xiao, et al. "An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment." Biomaterials Science 8, no. 8 (2020): 2202–11. http://dx.doi.org/10.1039/c9bm01794a.

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Lin, Chung-Yin, and William G. Pitt. "Acoustic Droplet Vaporization in Biology and Medicine." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/404361.

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This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV) in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU) sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles.

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Grisanti, Giulia, Davide Caprini, Giorgia Sinibaldi, Chiara Scognamiglio, Giulia Silvani, Giovanna Peruzzi, and Carlo Massimo Casciola. "A Microfluidic Platform for Cavitation-Enhanced Drug Delivery." Micromachines 12, no. 6 (June 3, 2021): 658. http://dx.doi.org/10.3390/mi12060658.

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An endothelial-lined blood vessel model is obtained in a PDMS (Polydimethylsiloxane) microfluidic system, where vascular endothelial cells are grown under physiological shear stress, allowing -like maturation. This experimental model is employed for enhanced drug delivery studies, aimed at characterising the increase in endothelial permeability upon microbubble-enhanced ultrasound-induced (USMB) cavitation. We developed a multi-step protocol to couple the optical and the acoustic set-ups, thanks to a 3D-printed insonation chamber, provided with direct optical access and a support for the US transducer. Cavitation-induced interendothelial gap opening is then analysed using a customised code that quantifies gap area and the relative statistics. We show that exposure to US in presence of microbubbles significantly increases endothelial permeability and that tissue integrity completely recovers within 45 min upon insonation. This protocol, along with the versatility of the microfluidic platform, allows to quantitatively characterise cavitation-induced events for its potential employment in clinics.

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Bhargava, Aarushi, Kaiyuan Peng, Jerry Stieg, Reza Mirzaeifar, and Shima Shahab. "Focused ultrasound actuation of shape memory polymers; acoustic-thermoelastic modeling and testing." RSC Adv. 7, no. 72 (2017): 45452–69. http://dx.doi.org/10.1039/c7ra07396h.

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Tu, Juan, and Alfred C. H. Yu. "Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors." BME Frontiers 2022 (January 30, 2022): 1–17. http://dx.doi.org/10.34133/2022/9807347.

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Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation, is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to living cells. Nevertheless, this emerging drug delivery paradigm has not yet reached widespread clinical use, because the efficiency of sonoporation is often deemed to be mediocre due to the lack of detailed understanding of the pertinent scientific mechanisms. Here, we summarize the current observational evidence available on the notion of sonoporation, and we discuss the prevailing understanding of the physical and biological processes related to sonoporation. To facilitate systematic understanding, we also present how the extent of sonoporation is dependent on a multitude of factors related to acoustic excitation parameters (ultrasound frequency, pressure, cavitation dose, exposure time), microbubble parameters (size, concentration, bubble-to-cell distance, shell composition), and cellular properties (cell type, cell cycle, biochemical contents). By adopting a science-backed approach to the realization of sonoporation, ultrasound-mediated drug delivery can be more controllably achieved to viably enhance drug uptake into living cells with high sonoporation efficiency. This drug delivery approach, when coupled with concurrent advances in ultrasound imaging, has potential to become an effective therapeutic paradigm.

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Karra, Nikita, Joao Fernandes, Emily Jane Swindle, and Hywel Morgan. "Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system." Biomicrofluidics 16, no. 5 (September 2022): 054102. http://dx.doi.org/10.1063/5.0100019.

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Organ on a chip or microphysiological systems (MPSs) aim to resolve current challenges surrounding drug discovery and development resulting from an unrepresentative static cell culture or animal models that are traditionally used by generating a more physiologically relevant environment. Many different airway MPSs have been developed that mimic alveolar or bronchial interfaces, but few methods for aerosol drug delivery at the air–liquid interface exist. This work demonstrates a compact Surface Acoustic Wave (SAW) drug delivery device that generates an aerosol of respirable size for delivery of compounds directly onto polarized or differentiated epithelial cell cultures within an airway barrier MPS and conventional static inserts. As proof of principle, the SAW drug delivery device was used to nebulize viral dsRNA analog poly I:C and steroids fluticasone and dexamethasone without disrupting their biological function.

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Arifi, Fathia F., and Michael L. Calvisi. "Optimal control of the nonspherical oscillations of encapsulated microbubbles." Journal of the Acoustical Society of America 151, no. 4 (April 2022): A108. http://dx.doi.org/10.1121/10.0010804.

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Encapsulated microbubbles (EMBs) were originally developed as contrast agents for ultrasound imaging but are more recently emerging as vehicles for intravenous drug and gene delivery. Ultrasound can excite nonspherical oscillations, or shape modes, that can enhance the acoustic signature of an EMB and also incite rupture, which promotes drug and gene delivery at targeted sites. Therefore, the ability to control shape modes can improve the efficacy of both the diagnosis and treatment mediated by EMBs. This work uses optimal control theory to determine the ultrasound input that maximizes a desired nonspherical EMB response (e.g., to enhance scattering or rupture), while minimizing the total acoustic input in order to enhance patient safety and reduce unwanted side effects. The optimal control problem is applied to a model of an EMB that accounts for small amplitude shape deformations. This model is solved subject to a cost function that maximizes the incidence of rupture or acoustic echo while minimizing the acoustic energy input. The optimal control problem is solved numerically through pseudospectral collocation methods using commercial optimization software. Single frequency and broadband acoustic forcing schemes are explored and compared. The results show that broadband forcing significantly reduces the acoustic effort required to incite EMB rupture relative to single frequency schemes. Furthermore, the acoustic effort required depends strongly on the shape mode that is forced to become unstable.

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Marin, Alexander, Md Muniruzzaman, and Natalya Rapoport. "Acoustic activation of drug delivery from polymeric micelles: effect of pulsed ultrasound." Journal of Controlled Release 71, no. 3 (April 2001): 239–49. http://dx.doi.org/10.1016/s0168-3659(01)00216-4.

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Dayton, Paul A., and Katherine W. Ferrara. "The application of acoustic radiation force for molecular imaging and drug delivery." Journal of the Acoustical Society of America 117, no. 4 (April 2005): 2472–73. http://dx.doi.org/10.1121/1.4787507.

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Ho, Yi-Ju, Chin-Chou Wu, Zong-Han Hsieh, Ching-Hsiang Fan, and Chih-Kuang Yeh. "Thermal-sensitive acoustic droplets for dual-mode ultrasound imaging and drug delivery." Journal of Controlled Release 291 (December 2018): 26–36. http://dx.doi.org/10.1016/j.jconrel.2018.10.016.

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Yeingst, Tyus J., Julien H. Arrizabalaga, and Daniel J. Hayes. "Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels." Gels 8, no. 9 (September 1, 2022): 554. http://dx.doi.org/10.3390/gels8090554.

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Stimuli-responsive hydrogel drug delivery systems are designed to release a payload when prompted by an external stimulus. These platforms have become prominent in the field of drug delivery due to their ability to provide spatial and temporal control for drug release. Among the different external triggers that have been used, ultrasound possesses several advantages: it is non-invasive, has deep tissue penetration, and can safely transmit acoustic energy to a localized area. This review summarizes the current state of understanding about ultrasound-responsive hydrogels used for drug delivery. The mechanisms of inducing payload release and activation using ultrasound are examined, along with the latest innovative formulations and hydrogel design strategies. We also report on the most recent applications leveraging ultrasound activation for both cancer treatment and tissue engineering. Finally, the future perspectives offered by ultrasound-sensitive hydrogels are discussed.

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George, Benedikt, Michael Fink, Helmut Ermert, Stefan J. Rupitsch, Pia T. Hiltl, and Geoffrey Lee. "Investigation of the Inertial Cavitation Activity of Sonosensitive and Biocompatible Nanoparticles for Drug Delivery Applications Employing High Intensity Focused Ultrasound." Current Directions in Biomedical Engineering 5, no. 1 (September 1, 2019): 585–88. http://dx.doi.org/10.1515/cdbme-2019-0147.

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AbstractAn approach to improve chemotherapy, while minimizing side effects, is a local drug release close to the tumorous tissue. For this purpose, the active drug component is often bound to nanoparticles employed as drug carriers. In the present study, we investigate sonosensitive, biocompatible poly-(L)-lactic acid (PLA) nanoparticles, which shall be used as drug carriers. For drug release, High Intensity Focused Ultrasound (HIFU) will be employed to introduce inertial cavitation, which separates the active drug component from the drug carrier. The cavitation effect generates an acoustic noise signal, which characterizes the cavitation activity and is expected to serve simultaneously as an indicator for the release of the active drug component. Depending on the ultrasound frequency, different acoustic levels of the inertial cavitation activity were measured. Investigations using a setup for passive cavitation detection (PCD) deliver quantitative results regarding the frequency dependence of the cavitation activity level of nanoparticles and reference media.

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Lin, Chia-Wei, Ching-Hsiang Fan, and Chih-Kuang Yeh. "The Impact of Surface Drug Distribution on the Acoustic Behavior of DOX-Loaded Microbubbles." Pharmaceutics 13, no. 12 (December 4, 2021): 2080. http://dx.doi.org/10.3390/pharmaceutics13122080.

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Previous studies have reported substantial improvement of microbubble (MB)-mediated drug delivery with ultrasound when drugs are loaded onto the MB shell compared with a physical mixture. However, drug loading may affect shell properties that determine the acoustic responsiveness of MBs, producing unpredictable outcomes. The aim of this study is to reveal how the surface loaded drug (doxorubicin, DOX) affects the acoustic properties of MBs. A suitable formulation of MBs for DOX loading was first identified by regulating the proportion of two lipid materials (1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-distearoyl-sn-glycero-3-phospho-rac-glycerol sodium salt (DSPG)) with distinct electrostatic properties. We found that the DOX loading capacity of MBs was determined by the proportion of DSPG, since there was an electrostatic interaction with DOX. The DOX payload reduced the lipid fluidity of MBs, although this effect was dependent on the spatial uniformity of DOX on the MB shell surface. Loading DOX onto MBs enhanced acoustic stability 1.5-fold, decreased the resonance frequency from 12–14 MHz to 5–7 MHz, and reduced stable cavitation dose by 1.5-fold, but did not affect the stable cavitation threshold (300 kPa). Our study demonstrated that the DOX reduces lipid fluidity and decreases the elasticity of the MB shell, thereby influencing the acoustic properties of MBs.

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Le, Thi H., An H. T. Phan, Khoa C. M. Le, Thy D. U. Phan, and Khoi T. Nguyen. "Utilizing polymer-conjugate albumin-based ultrafine gas bubbles in combination with ultra-high frequency radiations in drug transportation and delivery." RSC Advances 11, no. 55 (2021): 34440–48. http://dx.doi.org/10.1039/d1ra04983f.

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Ultrafine bubbles stabilized by human serum albumin conjugate polyethylene glycol ameliorates the stability of complex as well as the drug payload. Polyethylene glycol presents the crucial role in releasing drug by means of acoustic sound.

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Zhang, Nongshan, Yiyun Wu, Runlin Xing, Bo Xu, Dai Guoliang, and Peimin Wang. "Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/3273816.

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Brucine is the active component in traditional Chinese medicine “Ma-Qian-Zi” (Strychnos nux-vomica Linn), with capabilities of analgesic, anti-inflammatory, anti-tumor and so on. It is crucial how to break through the impact of cuticle skin which reduces the penetration of drugs to improve drug transmission rate. The aim of this study is to improve the local drug concentration by using ultrasound. We used fresh porcine skin to study the effects of ultrasound on the transdermal absorption of brucine under the influence of various acoustic parameters, including frequency, amplitude and irradiation time. The transdermal conditions of yellow-green fluorescent nanoparticles and brucine in skin samples were observed by laser confocal microscopy and ultraviolet spectrophotometry. The results show that under ultrasonic conditions, the permeability of the skin to the fluorescent label and brucine (e.g., the depth and concentration of penetration) is increased compared to its passive diffusion permeability. The best ultrasound penetration can make the penetration depth of more than 110 microns, fluorescent nanoparticles and brucine concentration increased to 2-3 times. This work will provide supportive data on how the brucine is better used for transdermal drug delivery (TDD).

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Liu, Yang, Jing Li, Heming Chen, Yan Cai, Tianyu Sheng, Peng Wang, Zhiyong Li, Fang Yang, and Ning Gu. "Magnet-activatable nanoliposomes as intracellular bubble microreactors to enhance drug delivery efficacy and burst cancer cells." Nanoscale 11, no. 40 (2019): 18854–65. http://dx.doi.org/10.1039/c9nr07021d.

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Park, Donghee, Jinhee Yoon, Jingam Park, Byungjo Jung, Hyunjin Park, and Jongbum Seo. "Transdermal Drug Delivery Aided by an Ultrasound Contrast Agent: An In Vitro Experimental Study." Open Biomedical Engineering Journal 4, no. 1 (February 11, 2010): 56–62. http://dx.doi.org/10.2174/1874120701004010056.

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Sonophoresis temporarily increases skin permeability such that medicine can be delivered transdermally. Cavitation is believed to be the predominant mechanism in sonophoresis. In this study, an ultrasound contrast agent (UCA) strategy was adopted instead of low frequency ultrasound to assure that cavitation occurred, and the efficacy of sonophoresis with UCA was quantitatively analyzed by optical measurements. The target drug used in this study was 0.1 % Definity® in 70% glycerol, which was delivered into porcine skin samples. Glycerol was used because it is an optical clearing agent, and the efficiency of glycerol delivery could be analyzed with optical measurements. The applied acoustic pressure was approximately 600 kPa at 1 MHz ultrasound with a 10% duty cycle for 60 minutes. Experimental results indicated that the measured relative contrast (RC) after sonophoresis with UCA was approximately 80% higher than RC after sonophoresis without UCA. In addition, the variance of RC was also reduced by more than 50% with the addition of a UCA. The use of a UCA appeared to increase cavitation, demonstrating that the use of a UCA can be effective in transdermal drug delivery (TDD).

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Mabvaro, Tapihwa, and Jacinta Browne. "Characterisation of the acoustic output of three sonoporation drug delivery ultrasound systems using an acoustic radiation force balance." Physica Medica 28, no. 4 (October 2012): 343. http://dx.doi.org/10.1016/j.ejmp.2012.06.041.

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Kang, Shih-Tsung, and Chih-Kuang Yeh. "Intracellular Acoustic Droplet Vaporization in a Single Peritoneal Macrophage for Drug Delivery Applications." Langmuir 27, no. 21 (November 2011): 13183–88. http://dx.doi.org/10.1021/la203212p.

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Journal articles on the topic 'Acoustic drug delivery'

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