Academic literature on the topic 'Acosta Collection (San Juan, Puerto Rico)'

Introduction: Acute myeloid leukemia (AML) is a cancer notorious for being quite challenging to manage clinically and having a high death rate among adults. In Puerto Rico (PR), the University Hospital (UH) is the major referral center for adults diagnosed with AML. However, a comprehensive study of this population is lacking, representing a knowledge gap. The objective of this retrospective study was to assess the clinical aspects, presentations and outcomes of the AML patients treated at this single institution, thus, filling a clinical and scientific need. Methods: This study evaluated patients ≥18 years of age, diagnosed with AML between January 2004 and December 2013 and treated at the UH within the Medical Center in San Juan, PR. Data regarding socio-demographics, bone marrow aspiration and biopsy, flow cytometry, cytogenetics, treatment and survival were obtained from medical records. Univariate and bivariate analyses were performed. Results: Of a total of 319 AML cases where the majority of the necessary data was obtained, the patients were mostly females (54.5%), between 41-64 y/o (43.9%), and living in the greater metropolitan area of San Juan or adjacent municipalities. Flow cytometry results mostly expressed the myeloid markers: CD13 (82%), CD117 (74%) and CD33 (68%), followed by the lineage independent antigens HLA-DR (59%) and CD34 (57%). Monoblastic expression were mostly CD64 (34%) and CD11c (31%), and the most frequent lymphoid markers were CD7 (14%) and CD4 (11%). Cytogenetic abnormalities were present in 68% of the patients, which were then sub-classified as simple (only 1) in 54%, double in 19% or complex (≥3) in 27%, and mostly involved chromosomes 17 (27%), 15 (26%), 8 (12%), 21 (10%) and 6 (6%). Of note, acute promyelocytic leukemia (APL) was diagnosed in 17% of the patients having available cytogenetics data. Regarding treatment, the predominant induction regimen was the standard 7+3, with idarubicin as the most frequent anthracycline used; 25% of patients that received treatment required a re-induction, consisting mostly of a 5+2 regimen with the same drugs used initially. Subsequently, 48% of the initially treated patients received their first consolidation therapy. Although limited by unknown values, evidence of leukemia relapse was noted in at least 12% of all treated patients, occurring on average within 51.6 weeks, where 50% of the data resulted within 41.9 weeks. Excluding the APLs, leukemia relapse was noted in 25% of the patients. By the end of the study in 2016, 75.7% of the patients had died, and were more likely to be ≥65 of age than 41-64 or 18-40 (85% vs. 71% vs. 69%, respectively; p=0.02); or having complex cytogenetics than simple/double or normal (85% vs. 67%, vs. 77%, respectively; p=0.048). Among those that died, the average life span was about 40 weeks since diagnosis. On the other hand, those remaining alive at the end of the study have an average life span of 70.7 weeks from diagnosis till their last known visit. Conclusion: This first analysis presentation of our 10-year retrospective study provides valuable clinical information about the AMLs being treated at the UH. The most significant clinical factors impacting survival were: age at diagnosis and amount of cytogenetic abnormalities. A necessary sub-analysis regarding the impact of the cytogenetic abnormality type will follow, as the data was not readily available at this time. Since the UH is the major referral center on the island, we can safely say it represents the AMLs of Puerto Rico, an underrepresented Latino population from the Caribbean area. In spite of limitations in data collection, especially from earlier years (2004-2007), the numbers are still robust enough (in light of being an infrequent cancer type) to consider this study as the first comprehensive assessment of the AMLs in PR. Our findings provide insight into the clinical presentation and outcomes of AMLs in PR, and may serve as a platform for future comparison studies regarding race/ethnicity and disparities. Further identification of clinical factors and genetic/epigenetic abnormalities is important in order to individualize therapy and hopefully improve outcomes in our AML population. Disclosures No relevant conflicts of interest to declare.

This issue of Pure and Applied Chemistry (PAC) is special for several reasons. It is an opportunity for IUPAC to celebrate the inauguration of the International Year of Chemistry 2011 (IYC 2011), so the content departs from the usual conference papers, technical reports, or recommendations, in favor of a collection of articles by past winners of the IUPAC Prize for Young Chemists, from inception of this annual competition in 2000 up to 2009.1 This Prize was created “to encourage outstanding young research scientists at the beginning of their careers”, and has richly fulfilled its founding objectives to recognize young talent, with the award of no less than 46 prizes over the years and honorable mention of many competitors whose excellent contributions did not receive the highest accolade.The declared goals of IYC 2011 are to “increase public appreciation of chemistry in meeting world needs, to encourage an interest in chemistry among young people, and to generate enthusiasm for the creative future of chemistry”. By happy coincidence, 2011 is the 100th anniversary of the Nobel Prize awarded to Marie Curie, and is thus also an opportunity to celebrate the contributions of women to science, and recognize the ongoing challenge of ensuring equal opportunity for all in career development. Most importantly, Marie Curie is an inspirational role model, not only to women but to all young students, and it is altogether fitting that the coming generation of scientists should be closely identified with IYC 2011, since enthusiasm is a defining characteristic of youth.IUPAC recognizes and wholeheartedly undertakes its duty to encourage and support young scientists throughout the world. As a global, scientific, nongovernmental organization, it contributes in a variety of distinctive ways to inspiring and helping young scientists to study and embark upon careers in chemistry. The Prize for Young Chemists is merely one such regular activity which, apart from monetary reward, enables recipients to attend an IUPAC Congress and the opportunity to showcase their achievements in an annual PAC Special Topic collection of invited, peer-reviewed articles, which has generated an outstanding published record since 2002.2In a more recent initiative commencing 2008, IUPAC has allocated a grant to enable economically disadvantaged countries to participate in the annual International Chemistry Olympiad. More generally, IUPAC operates a Financial Support for Conferences program to promote opportunities for young scientists and advanced students, particularly from scientifically emerging regions, to attend selected international conferences. The Young Ambassadors for Chemistry program was established as a partnership between the IUPAC Committee on Chemistry Education and Science Across the World, to facilitate interaction with teachers and students to increase public appreciation for and understanding of chemistry.An important feature of ongoing IUPAC strategy is to familiarize younger scientists with Union activities, and attendant opportunities for service to the international community. The Affiliate Membership Program was established in the 1980s to encourage individuals with an interest in IUPAC activities to sustain a direct relationship with the Union. Additional incentives to developing and economically disadvantaged countries include certain numbers of free affiliate memberships for young chemists. In a complementary initiative, the Young Observers Program sponsors young scientists to attend IUPAC General Assemblies and to participate as observers in selected activities and deliberations by invitation.The passage of IYC 2011 will be marked by a rich international program of activities, in which IUPAC features prominently in three cornerstone events, namely, the formal launch and closing, and the 43rd IUPAC Congress. The latter event will take place in San Juan, Puerto Rico on 30 July to 7 August 2011,3 and offers additional incentives for young scientists to attend and participate in a unique international celebration of chemistry.4 The winners of the 2010 and 2011 Prize for Young Chemists will attend as active delegates, and the award ceremony will have special significance in perpetuating a tradition that recognizes the hand of youth in shaping the future of chemistry.This issue of PAC pays its own tribute to the many brilliant young scientists who have been recognized by the Prize for Young Chemists jury over the past 10 years. We are grateful to those who accepted the invitation to contribute to this special collection, fittingly subtitled “Perspectives and Challenges for the International Year of Chemistry”. It is hoped that the contents will inspire and enthuse readers with fascinating insights into new and emerging aspects of chemical sciences. I am very honored to have had the opportunity to write this Preface, and thereby to congratulate all prize winners, past and present, and wish them fulfilling and successful careers, driven by enthusiasm and belief in the great future of our discipline.Nicole MoreauIUPAC President1 The works of the 2010 winners feature in the December 2010 issue of PAC, http://www.iupac.org/publications/pac/82/12/.2 The full archival record of the Young Chemists’ Prize Collections can be accessed at http://www.iupac.org/publications/pac/special/.3 Consult http://www.iupac2011.org/ for details about the 43rd IUPAC Congress.4 Details of award programs targeted to encourage young chemist’s participation at the 43rd IUPAC Congress in Puerto Rico are available at http://www.iupac.org/web/nt/2010-11-05_43_Congress.

The San Juan Bay Estuary Program and the Corporation for the Conservation of the San Juan Bay Estuary, intends to develop a cost-effective and environmentally acceptable plan for water quality improvement and seagrass restoration in the Condado Lagoon. One of the principal challenges associated with this Project is evaluating options for dredge material sources (borrow sites), transport, and placement in the Condado Lagoon to achieve the ecological restoration goal. A potential borrow site has been identified in the northwestern side of San Juan Bay near La Esperanza Peninsula. The accretion of sediment near the Peninsula has inhibited tidal flushing to this area from San Juan Bay. The implementation of this Project would support the beneficial use initiative by dredging the shoaling material at La Esperanza Peninsula and filling the artificial depressions in Condado Lagoon to improve water circulation at both the dredge and fill sites; as well as providing habitat for epibenthic growth in the Lagoon. In March 2011, Tetra Tech performed baseline investigations in Condado Lagoon, Puerto Rico in support of the San Juan Bay Estuary Program’s Water Quality Improvement and Seagrass Restoration Project. Field investigations included a bathymetric (multibeam) survey, benthic community data collection and sediment sampling. The results of the surveys were used to characterize benthic habitats in the Lagoon and to assist in evaluating alternatives for restoring the Lagoon to a gradient that supports a diverse epibenthic assemblage of Lagoon and estuarine species, specifically seagrass communities. In addition to the above mentioned investigations, Caribbean Oceanography Group deployed GPS-tracked lagrangian drifters in the lagoon in order to gather current data for the calibration of a hydrodynamic model of the Condado Lagoon. The intent of the multibeam survey was to map the existing depths and bathymetric features within Condado Lagoon, with an emphasis on detailing the extents of seven artificial depressions. The results of the survey determined a minimum depth of 0.8 m and maximum depth of 10.4 m (2.6 to 34.1 ft) in the Lagoon. Maximum depths were recorded in the center of the dredge holes, which are located in the center and eastern end of the Lagoon. The results of the multibeam survey were also used to support depth-based in situ data collection of the benthic community. The results of the benthic survey indicate a regional separation in benthic community diversity and abundance. The south-central and southeastern sides of the Lagoon support low to no biotic cover. This is contrary to the biotic diversity and abundance at the western, north-central and northeastern sides of the Lagoon. The benthic data also showed a segregation of benthic community assemblages between three depth ranges (shallow 1.8 to 2.4 m [6.0 to 8.0 ft]; mid (2.7 to 5.8 m [9 to 19 ft]); and deep 6.1 to 9.1 m [20 to 30 ft]). The benthic community in the mid depth range supports the greatest diversity and abundance of organisms. The areas with little to no biotic cover correspond to the dredged areas of the Condado Lagoon. Typical of low energy environments, finer grained sediments are located in the central and eastern regions of the Lagoon. Grain size analyses reported coarse material at the La Esperanza Peninsula sample site and the western end of Condado Lagoon, which are indicative of currents and regular water exchange in these locations. Organic content decreases from west to east in the Lagoon which supports the observations of lower benthic cover in the south-central and southeastern Lagoon compared to the western region. Based on the 2011 baseline investigations, H. decipiens was determined to be the most prevalent seagrass species in the Lagoon, followed by T. testudinum. Fill volume calculations based solely on the bathymetric survey results, estimate between 132,211 and 488,719 cy of fill material needed to support a water depth gradient (2.7 to 5.8 m [9.0 to 19.0 ft]) conducive to H. decipiens and T. testudinum growth in the central and eastern portions of the Lagoon. More specifically, the baseline results suggest a preferred depth of 4.05 m (13.3 ft) for H. decipiens, which would require between approximately 317,629 and 336,504 cy of fill material to restore a portion of the Lagoon. Caribbean Oceanography Group (with the support of Tetra Tech) has modeled the circulation within the Lagoon using the Environmental Fluid Dynamics Code (EFDC) hydrodynamic model. Modeling results reveal a complex circulation within the Condado Lagoon that is largely wind driven. A statistical analysis of the wind record for NOAA’s U.S. Coast Guard Station ID 9755371, located at the western end of the model domain was carried out, and 70%, 80%, 90%, 95% and 98% exceedance levels were determined. Model results show that under the 98% wind speed exceedance scenario, two of the examined locations within the dredged area of the lagoon experience a shear stress large enough to trigger a minimum sand grain diameter requirement for stability through the Shields relation. The locations and their minimum sand grain diameters are: A-2 with 0.46 mm and A-3 with 0.21 mm. These grain sizes correspond to Medium Sand and Fine Sand, respectively (after Wentworth (1922)). Evaluation of the direction of the shear at the above mentioned locations reveals that a portion of the material eroded from location A-2 (the medium sand) will be deposited at location A-3, and the rest (the fine sand) will be deposited at some combination of locations A-4, A-5, A-6 and A-7. Likewise the material originally eroded from location A-3 (fine sand) will be deposited at some combination of locations A-4, A-5, A-6 and A-7. Therefore, any unstable material placed at locations A-2 and A-3 will merely be shifted to another location within the fill area with a lower shear stress where it will become stable. Therefore the requirements for fill stability in the Condado Lagoon in terms of grain size are: 1) In order to remain stable under a 98% exceedance wind event, fill at location A-2 should be composed of sand with a grain diameter greater than 0.46 mm. In other words, Medium to Coarse sand should be used to fill location A-2. 2) In order to remain stable under a 98% exceedance wind event, fill at location A-3 should be composed of sand with a grain diameter greater than 0.21 mm. In other words, Fine to Medium sand should be used to fill location A-3. Of note is the finding that any material too fine to remain stable at either A-2 or A-3 will be deposited at some combination of the remaining fill locations, and thus will not be lost from the fill area, nor will it be unstable and cause problems elsewhere in the lagoon. It should be kept in mind that the lower exceedance levels (95% or less) did not present any minimum sand grain size requirements for stability. For those cases, sand fill of any grain size remains stable. Likewise, a higher exceedance level than 98% would require coarser fill at A-2 and A-3 than that discussed above. In either case, however, the eroded material would remain within the fill area, being deposited the downstream at a more sheltered location

Objetivo: Determinar la participación social a partir de la exploración de intereses ocupacionales y uso de los espacios de vida de los adultos mayores de 60 años del corregimiento de Obonuco de la ciudad de San Juan de Pasto. Metodología: Estudio de tipo cuantitativo descriptivo, con una muestra de 70 adultos mayores de 60 años, a quienes se les aplicó el Cuestionario de intereses ocupacionales para el adulto mayor, que determina el tipo de actividad, nivel de interés, frecuencia, autoeficacia percibida y con quién lo realiza, y la evaluación de espacios de vida con el cuestionario Life Space Assessment (LSA). Resultados: Las actividades que se presentan con mayor grado de interés son, asistir a misa, bailar, visitar familia y amigos, con una frecuencia de una vez por semana, con alta percepción de autoeficacia, sin ninguna compañía de algún familiar, amigo o cuidador, además de tener interés por participar de grupos de estudio. Conclusión: Prevalecen las relaciones intrafamiliares e intrapersonales, que han demostrado que llegar a esta etapa de la vida no es un impedimento para socializar y compartir con los suyos y la comunidad. Referencias: Acosta, C. y González-Celis, A. (2009). Actividades de la vida diaria en adultos mayores: la experiencia de dos grupos focales. Psicología y Salud, 19(2), 289-293. Acuña-Gurrola, M. y González-Celis, A. (2010). Autoeficacia y red de apoyo social en adultos mayores. Journal of Behavior, Health & Social Issues, 2(2), 71-81. Benavides, L. (2015). Política Pública de Envejecimiento y Vejez 2013-2023. Recuperado de http://www.idsn.gov.co/index.php/noticias/2102-politica-publica-departamental-de-envejecimiento-y-vejez-2013-2023-en-el-departamento-de-narino Camacho, S. y Lachuma, I. (2014). Prácticas de autocuidado, capacidad funcional y depresión en adultos mayores. Recuperado de http://repositorio.unapiquitos.edu.pe/handle/UNAP/3539 Canales, A. (2015). 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