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Journal articles on the topic 'Acne Vulgaris therapy'

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Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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1

Ma, Ziyuan, and Nikolay G. Kochergin. "Microbiome and acne vulgaris." Russian Journal of Skin and Venereal Diseases 23, no. 6 (December 15, 2020): 388–94. http://dx.doi.org/10.17816/dv60039.

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Acne vulgaris is a highly prevalent inflammatory skin disease involving sebaceous follicle. Although the pathogensis of acne remains uncertain, skin microbes are considered to plays an essential role in acne vulgaris. Cutibacterium acnes is the most important microbe in acne pathogenesis and its several processes: colonization, over-proliferation and inflammation have long been thought to contribute to the disease. Moreover, Staphylococcus epidermidis and Malassezia also synergistically collaborate with Cutibacterium acnes. Besides, given the growing number of patients who are treatment resistant, assessments are needed on phenotypic changes in the skin microbiome with retinoids and antibacterial therapy. Further research on the role of microbes in the pathogenesis of acne and the relationship between pathogenic microbes is expected to provide a new theoretical basis for clinical treatment of acne.
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2

Moftah, Noha Hassan, and Nayera Hassan Moftah. "Non-pharmacologic treatment for acne vulgaris." CosmoDerma 2 (July 12, 2022): 51. http://dx.doi.org/10.25259/csdm_49_2022.

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Early rapid treatment of acne vulgaris is mandatory for improving the psychological behavior of acne patients and to avoid the occurrence of post acne scars that are still more frustrating and challenging condition in their treatment up till now. The current first line of treatment of acne vulgaris is the conventional pharmacological therapy including; keratolytics, topical or oral antibiotics, retinoids, and hormonal agents. Meanwhile, the use of this pharmacological therapy is not always beneficial because of poor compliance of the patients, occurrence of side effects of drugs and antibiotic resistance to Cutibacterium (C.) acne with high rate of recurrence. Therefore, non-pharmacological treatment is developed as safe and effective options for treating acne vulgaris. They are applied either as independent treatment modality, an adjunct to pharmacological therapy, or as maintenance therapy. There is no sufficient data on the classification of this treatment category. This review discusses the non-pharmacological therapy in management of acne vulgaris besides efficacy and safety of each type of treatment modality. The most commonly applied non-pharmacological therapies are diet control, counseling, dermocosmetics, comedo extraction, chemical peeling, cryotherapy, chemical peels, platelets rich plasma (PRP), botulinum neurotoxin A (BoNTA), light-based therapy and laser and photodynamic therapy (PDT). Regarding lasers and light sources, they can be subclassified according to their mechanism of action into devices targeting levels of C. acnes, function of the sebaceous unit, or both.
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3

Leyden, James J. "Therapy for Acne Vulgaris." New England Journal of Medicine 336, no. 16 (April 17, 1997): 1156–62. http://dx.doi.org/10.1056/nejm199704173361607.

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4

Macháčková, Kateřina. "Topical therapy of acne vulgaris." Dermatologie pro praxi 12, no. 1 (March 22, 2018): 20–24. http://dx.doi.org/10.36290/der.2018.005.

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5

Reznichenko, N. Yu, Yu G. Reznichenko, G. I. Reznichenko, and K. O. Veretelnyk. "EFFICACY AND SAFETY OF 20% AZELAIC ACID CREAM FOR PAPULO-PUSTULAR ACNE VULGARIS." Modern medical technology, no. 4(51) (December 20, 2021): 4–10. http://dx.doi.org/10.34287/mmt.4(51).2021.1.

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Purpose of the study. To determine the safety and efficacy of 20% azelaic acid cream in the treatment of patients with papulopustular acne vulgaris. Materials and methods. 65 patients with acne vulgaris were examined. The control group consisted of 30 healthy individuals. Acne severity was evaluated according to G. Michaelsson et al. scale, Cook’s scale, absolute number of papules and pustules. Assessment of quality of life was performed. Facial skin microbiocenosis was assessed. All patients with acne vulgaris applied 20% azelaic acid cream during 15 ± 2 days. Results and discussion. The use of 20% azelaic acid cream contributed to the rapid regression of inflammatory acne. After 10 days of treatment, the number of papulopustular elements decreased in 3 times. After 10 days of therapy acne score according to G. Michaelsson et al. decreased in 1,5 times and after 15 days of treatment – in 1,9 times. After 10 days of therapy the acne score on the Cook’s scale decreased in 1,4 times. At the end of the study the acne score on the Cook’s scale was 2,4 points. There was a significant decrease in the total number of bacteria, the number of coagulase-positive staphylococci, quantity of Propionibacterium acnes on facial skin in 15 days after the start of therapy. A significant difference in the average value of the DLQI was fixed before (18,9 ± 0,31) and at the end (8,1 ± 0,54) of treatment. Conclusions. The high effectiveness of 20% azelaic acid cream in treatment of papulopustular acne vulgaris was proved. 20% azelaic acid cream provides a rapid regression of inflammatory forms of acne, reduction of total quantity of bacteria and Propionbacterium acnes on skin.
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6

A. Elfekki, Rasha, Nesrin Samir, Nadia Hafez Ouda, and Asmaa S. Hegab. "Antibiotic Resistance Pattern of Propionibacterium acnes Isolated from Patients with Acne Vulgaris at the Dermatology Clinics of Kasr Al-Ainy Teaching Hospital Egypt." Egyptian Journal of Medical Microbiology 29, no. 3 (July 1, 2020): 1–8. http://dx.doi.org/10.51429/ejmm29301.

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Background: Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris since the beginning of the last century. Over several decades, topical and systemic antibiotics have been the main line of treatment for acne vulgaris. However, in the present era of increased antibiotic usage, resistant strains have emerged. Objectives: The aim of this study is to determine the antibiotic resistance pattern of P. acnes isolated from patients with acne vulgaris at the dermatology clinics of Kasr Al-Ainy teaching Hospital. Methodology: Specimens from 100 patients with acne vulgaris were extracted from the pustules, taken by sterile cotton swabs and transported by thioglycolate media. Each swab was inoculated onto two blood agar plates, one incubated aerobically at 37ºC for 24h and the other anaerobically for one week. P. acnes was identified by Gram stain and biochemical tests. Their sensitivity to doxycycline, erythromycin, clindamycin, tetracycline, azithromycin and trimethoprimsulfamethoxazole was determined on Muller Hinton media by disc diffusion method. Results were interpreted according to the National Committee for Clinical Laboratory Standards (NCCLS) guidelines. Results: A total of 44 P. acnes isolates were identified from 100 patients with acne vulgaris, out of which 22.7% were resistant to clindamycin, 11.4% were resistant to trimethoprim-sulfamethoxazole and 9% were resistant to erythromycin. Resistance to doxycycline, tetracycline or azithromycin was not detected. Trimethoprim-sulfamethoxazole showed statistically significant difference in the resistance pattern compared to patient’s sex (p = 0.029) and to receiving previous treatment (p = 0.018). Conclusion: P. acnes is prevalent in patients with acne vulgaris (44%) and resistant strains are detected especially in those who have received previous therapy for more than 2 weeks (68%). It is recommended that dermatologists and family physicians follow the guidelines for proper management of acne, with the judicious use of antibiotics, in order to prevent antibiotic resistance.
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7

Wu, Guan-Xuan, Yu-Wen Wang, Chun-Shien Wu, Yen-Hung Lin, Chih-Hsin Hung, Han-Hsiang Huang, and Shyh-Ming Kuo. "Therapeutic Efficacy of Sesquiterpene Farnesol in Treatment of Cutibacterium acnes-Induced Dermal Disorders." Molecules 26, no. 18 (September 21, 2021): 5723. http://dx.doi.org/10.3390/molecules26185723.

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Acne vulgaris is a highly prevalent skin disorder requiring treatment and management by dermatologists. Antibiotics such as clindamycin are commonly used to treat acne vulgaris. However, from both medical and public health perspectives, the development of alternative remedies has become essential due to the increase in antibiotic resistance. Topical therapy is useful as a single or combined treatment for mild and moderate acne and is often employed as maintenance therapy. Thus, the current study investigated the anti-inflammatory, antibacterial, and restorative effects of sesquiterpene farnesol on acne vulgaris induced by Cutibacterium acnes (C. acnes) in vitro and in a rat model. The minimum inhibitory concentration (MIC) of farnesol against C. acnes was 0.14 mM, and the IC50 of 24 h exposure to farnesol in HaCaT keratinocytes was approximately 1.4 mM. Moreover, 0.8 mM farnesol exhibited the strongest effects in terms of the alleviation of inflammatory responses and abscesses and necrotic tissue repair in C.acnes-induced acne lesions; 0.4 mM farnesol and clindamycin gel also exerted similar actions after a two-time treatment. By contrast, nearly doubling the tissue repair scores, 0.4 mM farnesol displayed great anti-inflammatory and the strongest reparative actions after a four-time treatment, followed by 0.8 mM farnesol and a commercial gel. Approximately 2–10-fold decreases in interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, found by Western blot analysis, were predominantly consistent with the histopathological findings and tissue repair scores. The basal hydroxypropyl methylcellulose (HPMC) gel did not exert anti-inflammatory or reparative effects on rat acne lesions. Our results suggest that the topical application of a gel containing farnesol is a promising alternative remedy for acne vulgaris.
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8

Johnson, Betty Anne, and Julia R. Nunley. "Topical therapy for acne vulgaris." Postgraduate Medicine 107, no. 3 (January 2000): 69–80. http://dx.doi.org/10.3810/pgm.2000.03.945.

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9

Hanfling, Seymour L. "TOPICAL THERAPY IN ACNE VULGARIS." Annals of the New York Academy of Sciences 82, no. 1 (December 15, 2006): 151–57. http://dx.doi.org/10.1111/j.1749-6632.1959.tb44892.x.

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10

Stoiljković, Sofija, Jasmina Tomin, Jelena Zˇivanov-Cˇurlis, Nenad Stoiljković, Dragoslav Basˇić, and Dusˇan Stosˇić. "Antibiotic therapy of acne vulgaris." Pharmacological Research 31 (January 1995): 374. http://dx.doi.org/10.1016/1043-6618(95)87754-1.

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11

Katsambas, Andreas, George Kontochristopoulos, Carmen Salavastru, and Clio Dessinioti. "Photodynamic therapy for acne vulgaris." Prime 1, no. 3 (July 2011): 42–50. http://dx.doi.org/10.1080/21598908.2011.601583.

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12

Layton, Alison. "Systemic therapy for acne vulgaris." Hospital Medicine 65, no. 2 (February 2004): 80–85. http://dx.doi.org/10.12968/hosp.2004.65.2.12064.

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13

Costa, Caroline Sousa, and Edileia Bagatin. "Evidence on acne therapy." Sao Paulo Medical Journal 131, no. 3 (2013): 193–97. http://dx.doi.org/10.1590/1516-3180.2013.1313616.

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Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin.
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14

Glavas Dodov, Marija, and Svetlana Kulevanova. "A review of phytotherapy of Acne vulgaris." Macedonian Pharmaceutical Bulletin 55 (November 2009): 3–22. http://dx.doi.org/10.33320/maced.pharm.bull.2009.55.001.

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Acne vulgaris (acne) is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory (comedones, open and closed) lesions. Propionibacterium acnes and Staphylococcus epidermidis are common pus-forming microbes responsible for the development of various forms of acne. This disease remains a common condition in industrialized societies, with many mainstream treatment options available. There are many acne products on the market, and making an appropriate selection can be daunting. Common therapies that are used for the treatment of acne include topical, systemic, hormonal, herbal and combination therapy. Topically used agents are benzoyl peroxide, antibiotics and retinoid. Systemically used agents are antibiotics and isotretinoin. However, all such treatments carry risks and none is completely satisfactory. Natural alternatives are gaining greater research support, and have much to offer clinically in this disorder. This review focuses primarily on herbal treatments for acne that show scientific evidence of clinical efficacy, as well as the more common herbs shown to be useful in the treatment of this dermatologic disorder.
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15

Mahmood, Wakas Saadi. "Toll like receptor 2(TLR2) in acne vulgaris patients before and after oral isotretinion therapy." AL-Kindy College Medical Journal 15, no. 1 (September 12, 2019): 110–13. http://dx.doi.org/10.47723/kcmj.v15i1.90.

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Background: Acne vulgaris is one of the top three most commonly encountered dermatological problems worldwide in both primary and secondary care. Human keratinocytes express functional TLR2 heterodimers. An increased expression of TLR2 was detected in the epidermis of inflammatory acne lesions, as observed in normal skin; the expression level increased with the degree of differentiation of the keratinocytes. TLR2 expression is upregulated in inflammatory acne lesions and induced by C. acnes. The current study conducted to assess the oral isotretinion treatment effect on the acne vulgaris patients by evaluated the Toll Like Receptor 2 as a major immune system marker in Acne vulgaris immune response. Methods: 50 patients with acne vulgaris seen in outpatient clinic of dermatology centre(Al-Baidhaa out clinic center) in Baghdad during the period 1/9/2017 to 1/8/2018. The diagnosis of patients were done by the specialist dermatologist only sever and moderate acne cases were chosen. Fifty serum samples were collected before oral isotretinion therapy, only forty-five serum samples were collected after 8 weeks of oral isotretinion therapy. All patients have received 0.5mg-1mg/kg/day of oral isotretinoin. The mean ages was 22 years(range, 16-36 years). A total of 50 patients, 36(72%) of patients were females and 14(28%) were males. Furthermore 43(86%) of cases have heredity history. Also control serum samples were collected from people without acne and they chose with the same mean ages. The serum samples were stored at -70°C for up to six months. ELISA test for quantitative determination of TLR2 human was done. Statistical analysis was done using T-test. Results: Highly significant statistical difference were noticed (p<0.001) when we compare study group after therapy with control group, also highly significant statistical difference was noticed (p<0.01) when we compare study group before therapy with control group. Conclusion: Significant decrease of TLR-2 level was noticed in study group after isotretinoin therapy in comparison with same group before therapy and also with the control group. Pronouncedly the effects of oral isotretinion suggest a path towards importance of this therapy as an anti-acne agent
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16

Kim, Shukho, Hyesoon Song, Jong Sook Jin, Weon Ju Lee, and Jungmin Kim. "Genomic and Phenotypic Characterization of Cutibacterium acnes Bacteriophages Isolated from Acne Patients." Antibiotics 11, no. 8 (August 2, 2022): 1041. http://dx.doi.org/10.3390/antibiotics11081041.

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Cutibacterium acnes is a pathogen that can cause acne vulgaris, sarcoidosis, endodontic lesions, eye infections, prosthetic joint infections, and prostate cancer. Recently, bacteriophage (phage) therapy has been developed as an alternative to antibiotics. In this study, we attempted to isolate 15 phages specific to C. acnes from 64 clinical samples obtained from patients with acne vulgaris. Furthermore, we sequenced the genomes of these three phages. Bioinformatic analysis revealed that the capsid and tape measure proteins are strongly hydrophobic. To efficiently solubilize the phage particles, we measured the adsorption rate, one-step growth curve, and phage stability using an SMT2 buffer containing Tween 20. Here, we report the genotypic and phenotypic characteristics of the novel C. acnes-specific phages.
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17

Asri, Rizkia Chairani, and Desy Nofita. "Adapalene-Benzyl Peroxide Combination as an Option for Acne Vulgaris Treatment: A Systematic Literature Review." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 9 (July 6, 2022): 2191–97. http://dx.doi.org/10.37275/bsm.v6i9.575.

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Background: Acne vulgaris affect 9,4% of the world population, especially in teenage age. Treatment of acne is based on severity; mild acne is treated with a topical agent, whereas moderate and severe acne is treated with topical and systemic agents. Topical therapy, including retinoids, antibiotics, and benzoyl peroxide, is the foundation of acne treatment. Adapalene-benzoyl peroxide therapy can be used in treatment to avoid antibiotic resistance. This study aimed to evaluate the efficacy and tolerance of adapalene/benzoyl peroxide topical treatment in mild to moderate acne vulgaris. Methods: This systematic review conducted a literature search through 3 databases, following PRISMA 2020 guidelines. Inclusion criteria were written in English or Indonesian, published in 2016-2020, a randomized controlled trial (RCT) study designed using human samples, and discussed the efficacy of topical adapalene-benzoyl peroxide in mild and moderate acne vulgaris. Studies that were unavailable in full text and based on secondary data were excluded. Results: Acne vulgaris lesions and scars decreased significantly with adapalene/benzoyl peroxide topical therapy. The addition of moisturizer to therapy can reduce the side effects of retinoate. Conclusion: The combination of adapalene/benzoyl peroxide can be an alternative treatment for mild to moderate acne.
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Subotić, Milica, and Verica Đuran. "Treatment of acne vulgaris: a literature review / Lečenje običnih akni (acne vulgaris) – pregled literature." Serbian Journal of Dermatology and Venerology 2, no. 1 (January 1, 2010): 13–20. http://dx.doi.org/10.2478/v10249-011-0018-8.

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Abstract Acne vulgaris is a common skin disease, which affects individuals of all races and ages. In Caucasians, almost 85% of individuals between 12 and 25 years, as well as 25% of adults, are affected with some forms of acne. The pathophysiology of acne is multifactorial, and thus, the treatment must cover all the possible causes of acne. For this reason, acne therapy is mostly a combination therapy, with the main goal to achieve clinical improvement, without scarring and residuals, as much as possible. The treatment should be planned individually, depending on the clinical appearance, severity and psychological profile of the patient. The treatment usually takes time and requires dedication and patience of both the patient and the physician.
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19

Agesti, Dyah, Suryani Dyah Astuti, and Arifa Mustika. "PENANGANAN JERAWAT SINDROM AKUMULASI DAHAK MENGGUNAKAN AKUPUNTUR DAN HERBAL JIANGHUANG." Journal of Vocational Health Studies 4, no. 1 (July 31, 2020): 15. http://dx.doi.org/10.20473/jvhs.v4.i1.2020.15-20.

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Background : Acne vulgaris is a chronic skin disease that occurs due to chronic inflammation of the pilosebaceous glands. Acne is clinically affected by an increase in sebum, Propionibacterium bacteria acne, hormones, genetic, stress, diet and the environment. In Chinese Medicine, acne vulgaris belongs to categories of Feng Ci, it is caused by wind-heat pathogens that attack the lungs and excessive consumption of spicy and oily foods resulting in accumulation of heat in the stomach and intestines. In Chinese Medicine, sebaceous glands are associated with the Lung and Spleen. Patients classified as acne with differentiation of accumulation of phlegm syndrome. Purpose: To know the effect of acupuncture therapy at LI-4 Hegu, ST-36 Zusanli , ST-40 Fenglong, SP-6 Sanyinjiao and herbal therapy using Jianghuang in patients Acne vulgaris with differentiation of accumulation of phlegm syndrome. Methods: Acupuncture therapy at LI-4 Hegu, ST-36 Zusanli , ST-40 Fenglong, SP-6 Sanyinjiao were given 12 times, 3 times a week, with the principle of therapy to reinforce phlegm, strengthen the spleen and raise the spleen. In herbal therapy the patient is given herbal Jianghuang (Curcuma longa.L) dose of 3 grams 12 times, 3 times a week. Results: Compound of curcumin which is antibacterial, anti-inflammatory, antioxidant and wound healing affects acne. Acupuncture and herbal therapy given 12 times, 3 times a week can overcome acne vulgaris. Conclusion: Acupuncture and herbal therapy can overcome the growth of acne.
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20

Snarskaya, E. S. "Antibacterial therapy of vulgar acne." Vestnik dermatologii i venerologii 95, no. 5 (December 17, 2019): 58–67. http://dx.doi.org/10.25208/0042-4609-2019-95-5-58-67.

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Purpose: to evaluate the efficacy and safety of minocycline in the therapy of medium-heavy and severe forms of acne vulgaris according to modern ideas about pathogenesis of the disease.Materials and methods. Long-term multi-purpose observation which included 28 patients with the established diagnosis of acne vulgaris, medium-weight and severe forms is made. Patients received monotherapy by Minoleksin® medicine, depending on severity — 50–100 mg a day. Prior to the research and after the end of treatment inspection of the patient with calculation the rash elements, clinical and biochemical blood analysis, a research of function of sebaceous glands, the laser scanning microscopy, a laser Doppler floumetry, definition of the dermatological index of quality of life, photography (was performed at the consent of the patient). In the course of therapy inspection of the patient and assessment of tolerance of drug was performed.Results. The evidence of efficiency of minocycline in treatment of vulgar acnes of average and heavy severity is obtained that is confirmed by visual dermatological indicators, non-invasive methods of a research (results of a sebumetriya, the confocal laser scanning microscopy, a Doppler floumetriya), indicators of the dermatological index of quality of life. When studying clinical and laboratory indicators security concerns are not revealed. The undesirable phenomena in the course of the research are not registered.Conclusion. Minolexin® (minocycline) is highly effective and safe drug for treatment of vulgar acnes of average and heavy severity and it can be recommended for practical application in out-patient practice.Conflict of interest: the author states that there is no potential conflict of interest requiring disclosure in this article.
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Abdelhamed, Farah M., Nourtan F. Abdeltawab, Marwa T. ElRakaiby, Rehab N. Shamma, and Nayera A. Moneib. "Antibacterial and Anti-Inflammatory Activities of Thymus vulgaris Essential Oil Nanoemulsion on Acne Vulgaris." Microorganisms 10, no. 9 (September 19, 2022): 1874. http://dx.doi.org/10.3390/microorganisms10091874.

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Antibiotics are frequently used in acne treatment and their prolonged use has led to an emergence of resistance. This study aimed to investigate the use of natural antimicrobials as an alternative therapy. The antimicrobial and anti-inflammatory activities of five commonly used essential oils (EOs) (tea tree, clove, thyme, mentha and basil EOs), and their possible mechanisms of action against Cutibacterium acnes and Staphylococcus epidermidis, were explored. The effect of the most potent EO on membrane permeability was elucidated and its anti-inflammatory action, when formulated as nanoemulsion, was tested in an in vivo acne model. The in vitro studies showed that thyme EO had the most potent antimicrobial and antibiofilm activity, with phenolics and terpenoids as main antimicrobial constituents of EO. Thyme EO affected cell membrane permeability of both bacterial species, evident by the detection of the leakage of intracellular ions and membrane integrity by the leakage of nucleic acids. Morphological alteration in bacterial cells was confirmed by transmission electron microscopy. Thyme EO nanoemulsion led to the suppression of an inflammatory response in acne animal models along with a bacterial load decrease and positive histopathological changes. Collectively, thyme EO nanoemulsion showed potent antimicrobial and anti-inflammatory effects compared to the reference antibiotics, suggesting its effectiveness as a natural alternative in acne treatment.
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Sumsuzzoha, Dr S. M., Dr Md Abdus Sattar, Dr Arun Kumar Das, and Dr Shaila Zaman. "A Comparative Study of Azithromycin Pulse Therapy with Minocycline in Acne Vulgaris." Saudi Journal of Medicine 7, no. 12 (December 8, 2022): 610–15. http://dx.doi.org/10.36348/sjm.2022.v07i12.002.

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Background: Acne vulgaris is a common dermatological problem. Acne is most commonly found in adolescents, caused by increased androgens in both sexes. It is usually caused due to Propionibacterium acnes. Minocycline is a newly introduced drug in treating acne vulgaris. On the other hand, it is assumed that azithromycin having a long half-life like can be very effective with better compliance in treating acne vulgaris. But we have not enough research-based comparative data regarding this issue. Objective: The objective of this study was to compare the efficacy and safety of azithromycin pulse therapy with minocycline in treating acne vulgaris. Methods: This was a prospective, comparative study and was conducted in Department of Dermatology, Naogaon Medical College, Naogaon, Bangladesh, during the period from January 2021 to December 2021. In total 80 patients with moderate-to-moderately severe (Grade II and III), acne vulgaris were included in the study population. Patients were randomly assigned to two treatment groups of group A & group B respectively. In group A, there were 25 patients received 500 mg azithromycin once a day for 3 days per week as pulse therapy along with 0.05% topical tretinoin for 3 months whereas in group B, there were another 25 patients received 50 mg minocycline twice a day along with 0.05% topical tretinoin for 3 months. All data were processed, analyzed, and disseminated by SPSS version 23.0 and MS Office program. Results: In this study, group A (Azithromycin) between baseline and final score distribution we found a significant correlation (P=0.023). On the other hand, in group B we did not find any significant correlation (P=0.073). In analyzing the changes in severity score of acne from baseline to the final assessment of both groups we observed, in group A at baseline 15%, 38%, and 48% of participants had the score points 2, 3, and 4 respectively whereas in the final stage 63%, 30%, and 8% participants had the score point 1, 2 and 3 respectively. So, in group A between baseline and final score distribution, we found a significant correlation (P=0.023). On the other hand, in group B at baseline 10%, 40%, and 50% of participants had the scored points 2, 3, and 4 respectively whereas in the final stage 65%, 28%, and 8% of participants had the score point 1, 2 and 3 respectively. In group B between baseline and final score distribution we found P value 0.073. Conclusion: In this study, the efficacy of both azithromycin pulse therapy and minocycline was found satisfactory. But as per the findings regarding the safety profiles, we can conclude that minocycline is safer than azithromycin pulse therapy in treating acne vulgaris.
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Al-Dhubaibi, Mohammed, Ghadah Alhetheli, Adel Alsenaid, and Ahmed Abd Elneam. "Serum Vitamin D Levels at Different Stages of Acne Vulgaris Patients Treated with Isotretinoin: A Prospective Study." Open Dermatology Journal 15, no. 1 (February 23, 2021): 11–15. http://dx.doi.org/10.2174/1874372202115010011.

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Background: Acne vulgaris is a common chronic inflammatory skin disorder of pilosebaceous units. Isotretinoin (13-cis retinoic acid) is the most effective multifunctional treatment for moderate-to-severe and nodulocystic acne. Vitamin D plays a role in the immune system, and its deficiency might contribute to the pathogenesis of acne. Objective: To investigate whether isotretinoin improves serum 25-hydroxyvitamin D levels in acne vulgaris patients. Methods: This prospective cohort study included 68 patients with acne vulgaris. Lipid profiles, liver function tests, and serum 25-hydroxyvitamin D [25 (OH) D] levels were measured at baseline and three months after starting isotretinoin treatment. Results: There was a significant increase in serum vitamin D levels three months after starting isotretinoin treatment in mild acne patients (P=0.0003). Conclusion: Vitamin D levels are altered in acne vulgaris. Isotretinoin therapy is associated with an increase in vitamin D levels, which was statistically significant in mild acne patients. Considering the role of vitamin D in acne, effective treatment with isotretinoin might highlight vitamin D as a possible target for acne therapy or as a biomarker for disease activity and remission.
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24

Dreno, Brigitte. "Topical Antibacterial Therapy for Acne Vulgaris." Drugs 64, no. 21 (2004): 2389–97. http://dx.doi.org/10.2165/00003495-200464210-00002.

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25

Ochsendorf, Falk. "Systemic antibiotic therapy of acne vulgaris." JDDG 4, no. 10 (October 2006): 828–41. http://dx.doi.org/10.1111/j.1610-0387.2006.06053.x.

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26

Cochran, Ronald J., Stephen B. Tucker, and Stephen A. Flannigan. "Topical Zinc Therapy for Acne Vulgaris." International Journal of Dermatology 24, no. 1 (January 1985): 188–90. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05425.x.

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Cochran, Ronald J., Stephen B. Tucker, and Stephen A. Flannigan. "Topical Zinc Therapy for Acne Vulgaris." International Journal of Dermatology 24, no. 3 (April 1985): 188–90. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05756.x.

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Yossy, Vesri, Wydya Yenny, and Lilik Norawati. "Microneedling Radiofrequency for Acne Vulgaris and Post-Acne Scarring: A Case Report." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 3 (January 11, 2022): 1443–45. http://dx.doi.org/10.37275/bsm.v6i3.456.

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Background: There are various therapeutic modalities for acne and post acne scarring, but the best option is to have a safe, effective with affordable cost such as monotherapy or combination therapy. One of the recommended combination therapy for acne vulgaris with atrophic acne scars is microneedling radiofrequency which can improve skin structure. Case report: A 25 year old male with moderate comedonal acne vulgaris and severe scarring. The patient came with complaints of uneven skin surface on both cheeks, forehead and chin which had been felt to increase since 3 years ago. The appearance of acne on the face has been felt since 12 years ago. The patient's parents and sister also had acne complaints. On dermatological examination, on the forehead, temples, cheeks, nose and chin found blackheads, whiteheads, papules, hyperpigmented macules, multiple atrophic acne scars. The treatment choice for this patient is microneedling radiofrequency in combination with topical therapy. Discussion: The combination of microneedling with radiofrequency is one of the therapeutic modalities for acne vulgaris and also post-acne scarring with minimal side effects. In the evaluation for 2 weeks after the procedure, this patient did not complaint of any adverse events.
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Nakase, Keisuke, Hidemasa Nakaminami, Yuko Takenaka, Nobukazu Hayashi, Makoto Kawashima, and Norihisa Noguchi. "Relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in Japan." Journal of Medical Microbiology 63, no. 5 (May 1, 2014): 721–28. http://dx.doi.org/10.1099/jmm.0.067611-0.

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Propionibacterium acnes and Staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these micro-organisms are considered to contribute to the inflammation of acne. In the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of P. acnes and S. epidermidis isolated from patients with acne vulgaris in a university hospital in Japan from 2009 to 2010. Additionally, we analysed the relationship between the antimicrobial resistance of P. acnes and the severity of acne vulgaris. Some P. acnes strains (18.8 %; 13/69) were resistant to clindamycin. All strains had a mutation in the 23S rRNA gene, except for one strain that expressed erm(X) encoding a 23S rRNA methylase. Tetracycline-resistant P. acnes strains were found to represent 4.3 % (3/69) of the strains, and this resistance was caused by a mutation in the 16S rRNA gene. Furthermore, three strains with reduced susceptibility to nadifloxacin (MIC = 16 µg ml−1) were detected. When analysing the correlation between the antimicrobial resistance of P. acnes and S. epidermidis, more than 80 % of the patients who carried clindamycin-resistant P. acnes also carried clindamycin-resistant S. epidermidis. However, no epidemic strain that exhibited antimicrobial resistance was detected in the P. acnes strains when analysed by PFGE. Therefore, our results suggest that the antimicrobial resistance of P. acnes is closely related to antimicrobial therapy. Additionally, those P. acnes strains tended to be frequently found in severe acne patients rather than in mild acne patients. Consequently, the data support a relationship between using antimicrobial agents and the emergence of antimicrobial resistance.
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Nikolayeva, N. N. "Aspects of comprehensive treatment for adolescents with acne vulgaris from the perspective of psychological counseling." Russian Journal of Skin and Venereal Diseases 23, no. 2 (August 9, 2020): 119–28. http://dx.doi.org/10.17816/dv41935.

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This article discusses the manifestations of the adolescence crisis in patients with acne vulgaris, using a four-level personality model (biological, psychological, social, and spiritual levels). On the one hand, the adolescence crisis can trigger acne vulgaris in case of a genetic predisposition; on the other hand, acne can aggravate the process of experiencing the adolescence crisis. The authors suggest the use of psychological counseling (relaxation techniques, methods of rational psychotherapy, etc.) within the dermatological care for adolescent patients with mild and moderate acne vulgaris. The authors present the results of a study of the efficacy of comprehensive therapy (including psychological counseling) in adolescent patients with mild-to-moderate acne vulgaris, compared with traditional dermatotropic therapy. Statistically significant differences between two groups were revealed in the changes in the indicators of the mental condition presentation (r = -0.90; p 0.05), the dermatological index of acne (DIA) (r = -0.34; p 0.05), and indicators of quality of life (r = -0.72 and r = -0.68. according to the questionnaires of the Dermatology Life Quality Index and Skindex-29, resp.; p 0.05). Simultaneous improvement in the psychoemotional status was correlated with positive cutaneous changes, as evidenced by the direct rather than pronounced statistically significant relationship between the indices of the experience scale and the ADI index (r = 0.52; p 0.05). The obtained results show that the use of psychological counseling in the comprehensive treatment for adolescents with mild-to-moderate acne vulgaris is more effective compared with the traditional dermatotropic therapy.
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Amalia, Amirul, and Sulistiyowati Sulistiyowati. "The Effect of Banana Skin on Acne Vulgaris." Jurnal Keperawatan 10, no. 1 (March 24, 2019): 1. http://dx.doi.org/10.22219/jk.v10i1.6061.

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ABSTRACTAcne vulgaris is a common inflammatory condition in the pilosebaceous unit that occurs in female adolescents and young adults characterized by blackheads, papules, pustules, nodules. A non-medical treatment is one of intervention which can be done to treat Acne vulgaris. One example of non-medical treatment is herbal therapy using banana skin. Banana skin contains antioxidants, anti-fungus, therefore it can accelerate the healing process, help to lift dead skin cells, and prevent the risk of new acne. This study aimed to determine the effectiveness of banana skin to treat Acne Vulgaris. This research used a pre-experimental with one group pretest and posttest design. The respondents were female adolescents in Gedangan Village Sukodadi Lamongan who include in the inclusion criteria. The data were analyzed using Wilcoxon Tests. The results showed that banana skin was found to be effectively decreased the symptoms of Acne vulgaris (p-value < 0.05). In conclusion, this study are expected to be additional information of the effect of a banana skin on Acne vulgaris in adolescents, and it may provide input for clinicians to manage Acne Vulgaris, especially in female adolescents.Keyword: Acne Vulgaris, Banana Skin, Female Adolescents
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Katkhanova, Olga A., Svetlana A. Grigoryants, and Irina I. Glazko. "Combination of isotretinoin and Contractubex Anti-Red in acne therapy." Russian Journal of Skin and Venereal Diseases 24, no. 3 (June 15, 2021): 285–96. http://dx.doi.org/10.17816/dv64197.

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BACKGROUND: Acne vulgaris (acne vulgaris) is an urgent interdisciplinary problem. Analyzing modern scientific data on the development of acne vulgaris, it is necessary to focus on the role of inflammation that accompanies dermatosis at all its stages of development, sometimes preceding the formation of clinical symptoms. Prolonged chronic recurrent course, difficulties in choosing the correct therapy tactics, sometimes unreasonable medical interventions, exacerbation, improper skin care lead to the formation of a number of complications. AIMS: To optimize and improve the effectiveness of therapy in patients with moderate and severe degrees acne using isotretinoin and the combined innovative gel Contractubex Anti-Red. MATERIALS AND METHODS: The study included 60 patients aged 18 to 45 years with moderate to severe acne. Isotretinoin was prescribed in standard dosages. To study the effect of Сontraktubex Anti-Red on the dynamics of post-acne, patients with atrophic post-acne scars were divided into 3 subgroups, depending on the regimen of drug use. RESULTS: Almost complete relief of the inflammatory process, regression of elements was noted 12 months after the use of complex therapy, the value of the dermanologic index of acne (DIA) index was more than 70% noted in 62% of patients, significant improvement in 38%. The severity of post-acne scars on the SCAR-S scale changed significantly during treatment and in 53.3% this indicator was 1. The Cadi index decreased by 70% compared to the baseline. CONCLUSION: Good cosmetic effect, safety, absence of side effects, comfort and ease of use make it possible to recommend Contractubex Anti-Red together with basic acne therapy.
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M., Pooja, Rajendra Holla, Girisha B. S., and Puneeth A. "A study of prescription pattern in the drug therapy of acne vulgaris at a tertiary care hospital in Mangalore, India." International Journal of Basic & Clinical Pharmacology 7, no. 1 (December 23, 2017): 80. http://dx.doi.org/10.18203/2319-2003.ijbcp20175679.

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Background: Acne Vulgaris is the most common skin disorder of the pilosebaceous unit with excess sebum production, follicular epidermal hyperproliferation, inflammation and Propionibacterium acnes activity, affecting about 80% of teenagers and has considerable psychological and social consequences and physical disability. Use of established topical and oral drugs assumes paramount importance in the treatment of acne vulgaris. Therefore, periodic auditing of prescription is necessary to increase therapeutic benefit and decrease adverse effects. Aim and objectives of the study was to evaluate the pattern of prescription and its rationale in the drug therapy of acne vulgaris. To monitor the adverse effects, if any.Methods: A prospective, hospital based, observational study. Data was collected for a period of 1 year from January 2015 to December 2015 from the outpatient records in the OPD of Dermatology at Justice K.S. Hegde Charitable Hospital, Deralakatte, Mangalore, in a specifically designed proforma.Results: The prescription data of 346 patients were analyzed of which 45.1% were males with an average age of 21.94±0.3 years. Among the four grades of Acne Vulgaris, Grade II (53.17%) was more prevalent followed by Grade I (26.58%), Grade III (13.87%) and Grade IV (6.35%). The number of drugs prescribed for topical use was 514 of which the most commonly prescribed drugs were Benzoyl Peroxide (19.46%), a combination of Tretinoin and Clindamycin (17.12%), Tretinoin alone (12.45%), Clindamycin alone (10.51%) etc. The number of drugs prescribed for systemic use was 98 consisting of Doxycycline (55.1%), Azithromycin (34.7%), Isotretinoin (6.12%) and Erythromycin (4.08%).Conclusions: There was rationality in most of the prescriptions giving no scope for polypharmacy.
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Rahman, M. Moksedur, M. Abdullah, M. Moazzem Hossain, MA Siddique, M. Nessa, MK Rahman, Khan MMR, M. Zillur Rahman, SMA Taher, and SM AfzalUddin. "Topical Isotretinoin in Acne Vulgaris." TAJ: Journal of Teachers Association 29, no. 2 (December 3, 2018): 1–5. http://dx.doi.org/10.3329/taj.v29i2.39099.

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This study was carried out to evaluate the efficacy, safety and adverse effects of topical isotretinoin 0.05% gel in the treatment of acne vulgaris. This prospective study was undertaken in Skin & VD outpatient department of Rajshahi Medical College Hospital, Rajshahi. One hundred patients with mild tomoderate acne vulgaris were enrolled and were instructed to apply isotretinoin 0.05% gel once daily at night for 12 weeks. Patients were followed up at 2,4,8 and 12 weeks for efficacy and tolerability. Efficacy was measured by counting facial inflammatory and noninflammatory lesions and by grading acne severity. Cutaneous tolerance was assessed by determining erythema, scaling and burning with pruritus.Response was excellent in 80%of cases.None of the cutaneous reactions was severe, all were mild and well tolerated.Nobody had to discontinue the therapy for side effects. This study confirms that isotretinoin 0.05% gel is safe and effective topical therapy for mild to moderate acnevulgaris.TAJ 2016; 29(2): 1-5
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Gryazeva, N. V., A. V. Tamrazova, S. I. Surkichin, and L. S. Kholupova. "Use of physiotherapeutic methods in treatment of acne vulgaris." Medical alphabet 1, no. 27 (November 27, 2022): 11–13. http://dx.doi.org/10.33667/2078-5631-2022-27-11-13.

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Acne vulgaris is a chronic inflammatory disease that not only reduces the quality of life of patients, but also leaves persistent consequences in the form of scars and hyperpigmentation. Early and effective acne treatment is the main method of prevention in scar formation. Today, both topical and systemic medications are used in the treatment of acne, but the development of resistance to antibacterial drugs, the presence of contraindications to drugs, low compliance or ineffectiveness of therapy are pushing for the search for combined treatments. Even though little attention is paid to physiotherapeutic methods in domestic and foreign recommendations, these methods as part of combination therapy reduce the duration of acne treatment, help reduce the severity of cicatricial changes, and ultimately lead to more satisfactory cosmetic results. This article discusses the efficacy and safety of the most popular physiotherapy methods such as laser therapy, light therapy and chemical peels in the treatment of acne.
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Webster, Guy. "Combination azelaic acid therapy for acne vulgaris." Journal of the American Academy of Dermatology 43, no. 2 (August 2000): S47—S50. http://dx.doi.org/10.1067/mjd.2000.108318.

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Tan, Audrey W., and Hiok-Hee Tan. "Acne vulgaris: a review of antibiotic therapy." Expert Opinion on Pharmacotherapy 6, no. 3 (March 2005): 409–18. http://dx.doi.org/10.1517/14656566.6.3.409.

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Bhardwaj, Sachin S., Thomas E. Rohrer, and Kenneth Arndt. "Lasers and Light Therapy for Acne Vulgaris." Seminars in Cutaneous Medicine and Surgery 24, no. 2 (June 2005): 107–12. http://dx.doi.org/10.1016/j.sder.2005.04.001.

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Shamsi, Yasmeen. "Efficacy of Unani Combination Therapy in the Management of Acne Vulgaris: A Randomised Standard Controlled Study." Chettinad Health City Medical Journal 11, no. 03 (September 30, 2022): 10–16. http://dx.doi.org/10.24321/2278.2044.202223.

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Acne vulgaris is one of the common chronic inflammatory diseases of the pilosebaceous unit with multiple pathophysiologies affecting adolescents mainly. Aims: To evaluate the efficacy of Shahtra (Fumaria indica) orally along with the topical use of Zimad Muhasain and the management of moderate to severe category of acne vulgaris on the Global Acne Grading System (GAGS) scale. Material & Methods: This was a randomized standard control clinical study. The test group patients were given Shahtra ( 500 mg), 2 capsules twice daily with a local application of Zimad Muhasa paste once daily; the control group patients were given tablet Azithromycin 500 mg thrice weekly with a local application of Benzoyl peroxide 5% gel once daily for 8 weeks. Result: In the test group, there was a 77.3% reduction in the GAGS score at the final follow-up with p<0.0001; in the control group, there was a 69.8% reduction in GAGS score with p<0.0001, showing extremely significant improvement in both groups. The results indicate the superiority of the test group regimen over the control group by at least 7%. Furthermore, adverse effects like burning sensation, dryness, and itching due to Benzoyl peroxide and diarrhoea due to Azithromycin were only reported in the control group whereas the Unani formulations were found to be free of such adverse effects. Conclusion: The test formulations comprising a dried aqueous extract of Shahtra and Zimad Muhasa were found to be more effective and safe in the management of acne vulgaris in moderate to severe acne, compared to the control combination of Azithromycin and Benzoyl peroxide gel.
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Sapkota, Jenisha, Niraj Khatiwada, Bijendra Shah, and Shiv Mangal Prasad. "A case report on acne vulgaris." Healer 2, no. 02 (July 31, 2021): 98–101. http://dx.doi.org/10.51649/healer.75.

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There are various skin diseases affecting human beings but acne is the most commonly reported one. It is because face is the reflection of personality and acne affects mostly the skin of face. In Ayurveda face is one of the 56 Upangas mentioned and described at the top. Acharya Sushruta mentioned youvan pidika for the first time which can be correlated with acne. Youvan pidika means disease of young age. The main dosha vitiated in this disease is Rakta. So, Raktamokshan is done for sodhana of Rakta dosha. In the following case described, Raktamokshana is done using Jalauka Avacharana (Leech Therapy) was done to treat acne. Remarkable result was observed in the particular case.
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Gryazeva, N. V., and A. V. Tamrazova. "Assessment of quality of life in patients with severe acne." Medical alphabet, no. 9 (June 25, 2021): 11–15. http://dx.doi.org/10.33667/2078-5631-2021-9-12-15.

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Acne vulgaris is a common disease affecting up to 85 % of adolescents. Localization of dermatosis in cosmetically signifiant areas, the duration of the therapy and the formation of post-acne symptoms have a high psycho-emotional load and negatively affect the quality of life. Due to the fact that acne affects the most vulnerable and socially sensitive age group, it is imperative not to overlook psychological abnormalities such as anxiety, depression and suicidal thoughts. This review presents the types of diagnostic scales for assessing the quality of life of patients with acne, pathogenesis and risk factors for scar formation – the main factor affecting the self-esteem of patients with acne vulgaris, and also proposed new methods of combination therapy with the use of corticosteroids and isotretinoin in the treatment of severe forms.
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Hussain, Shabir, Amjad Mustafa, Arif Mumtaz, Mohammad Soban, Ghazala Shaheen, and Shafiq Ahmad. "Comparison of Efficacy of Azithromycin and Levamisole in Combination with Azithromycin in Patients of Moderate to Severe Acne." Pakistan Journal of Medical and Health Sciences 15, no. 9 (September 30, 2021): 2444–46. http://dx.doi.org/10.53350/pjmhs211592444.

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Objective: To compare the efficacy of azithromycin plus levamisole versus azithromycin in the treatment of moderate to severe acne. Design: It was a randomized controlled trial. Study Settings: This study was conducted at Department of Pharmacology over 1 year from March 2020 to March 2021 at Khalifa Gulnawaz Teaching Hospital, Bannu, Khyber Pakhtunkhwa & DHQ Teaching Hospital, Bannu, Khyber Pakhtunkhwa. Material and Methods: Sixty (120) patients of acne having either gender age between ≤18 to ≥28 years who meet the inclusion criteria were include in this study. Randomly patients were divided into two groups, in group A patients (n=60) were administered azithromycin (500 mg daily for 3 days in a week) plus levamisole (150 mg daily for two days in a week) for 8 weeks. In group B patients (n=60) patients were administered azithromycin 500 mg daily for 3 days for 8 weeks. “Acne Global Severity Score” was used for grading in patients who respond to treatment after 08 weeks therapy. Results: A total of 120 patients were enrolled in this study In Group-A Azithromycin + Levamisole, 19 males (31.66%) and 41 females (68.33%) and in Group-B (only Azithromycin) 23 males (38.33%) and 37 females (61.66%) were enrolled. Efficacy was noted in 52(86.66%) in patients of group-A receiving azithromycin plus levamisole combination where it was noted in 29(48.33%) in patients of group B receiving azithromycin (p=0.0031). Conclusion: It is concluded that for treatment of moderate acne vulgaris to severe acne vulgaris combination of azithromycin plus levamisole therapy proved more effective than azithromycin. However, there is need to conduct further comparative studies to measure efficacy in moderate acne vulgaris to severe acne vulgaris. Keywords: Azithromycin, Levanisole, Acne Vulgaris, Efficacy, Moderate Acne, Efficacy
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Listiawan, M. Yulianto, Cita Rosita Sigit Prakoeswa, Dhyah Aksarani Handamari, and Regitta Indira. "EFFECTS OF BLUE LIGHT EMITTING DIODE (LED) AND DOXYCYCLINE TO SEBACEOUS GLAND IN ACNE VULGARIS." Folia Medica Indonesiana 53, no. 4 (December 28, 2017): 272. http://dx.doi.org/10.20473/fmi.v53i4.7160.

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Acne vulgaris (AV) is an inflammation of pilosebaceous unit especially in young adult. The pathophysiology is the elevation of sebum production, keratinization of abnormal pilocebaseous follicles, and inflammation caused by immune response to Propionibacterium acnes. Therapy combination of oral antibiotics (doxycycline) and physical therapy (blue light) in moderate-severe acne is one option to reduce antibiotic resistance. Doxycycline is a commonly antibiotic used. The effects of photosensitive can increase the penetration of blue light by sebaceous glands. There was a total decrease in sebum and clinical improvement of combination therapy of blue light and doxycycline in seven patients. The combination therapy has been shown to improve its therapeutic effect, but more clinical trials are needed to prove the effectiveness of blue light with doxycycline than without blue light.
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Saxena, Vishal, and Krishana Yadav. "Glycolic Acid, Lactic Acid, Mandelic Acid, Salicylic Acid, Citric Acid, Gluconolactone: Skin Exfoliators in Combination Therapy of Acne Vulgaris." International Journal of Research in Engineering, Science and Management 3, no. 10 (October 16, 2020): 54–55. http://dx.doi.org/10.47607/ijresm.2020.334.

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Facial acne are a recurring issue in most of the population and can cause disturbing skin issues. A combination of Alpha-hydroxy acids, Beta-hydroxy-acids and Poly-hydroxy acids has become popular for treating acne vulgaris in last few years. The main objective of this research study is to evaluate the efficacy & safety of combination of these acids in the treatment of acne vulgaris. The study was conducted on 12 volunteers having mild to moderate to severe acne. They were divided into 3 groups according to the severity of their facial acne. Members of each group were treated with a series of 30% AHA, 2% BHA and 7% PHA. The improvement in their acne condition as well as skin texture was assessed over a period of 6 weeks.
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Sharma, Punita, Chhaju Ram Yadav, and Sarika Yadav. "TO EVALUATE THE EFFECT OF JALAUKAVCHARANA IN MANAGEMENT OF MUKHDUSHIKA W.S.R TO ACNE VULGARIS: A CASE STUDY." International Ayurvedic Medical Journal 04, no. 04 (June 2, 2020): 2357–62. http://dx.doi.org/10.46607//iamjp0404152020.

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In modern era, Acne is the most common skin disease facing mankind, it afflicts 80% of adolescent in population. In modern dermatology, a similar type of skin disorder named Acne vulgaris or Acne is found to have parity with the disease Mukhdushika or Yuvanpidika mentioned in Ayurvedic text. This problem is aggravated are increasing day by day due to excessive stress, hormonal imbalance, salty food, junk food and modern lifestyle. So, purpose of the study is to evaluate the application of Jalouka and herbo-mineral compound in Mukhdushika w.s.r to acne vulgaris. A 21 years old patient came in OPD (skin care unit) at NIA, Jaipur with the complaints of acne (nodular) for 1 year with pain, tenderness, burning, itching, discharge and discolouration diagnosed as Mukhdushika. Patient was administrated a herbomineral compound along with Jalaukavacharana with the follow up of 7 days. The main drugs of Herbomineral compounds were Manjishtha, Rasmanikya etc. all these drugs have the properties of Kushthaghna, Raktaprasadaka, Varnaprasadaka, Yakrit Uttejaka etc. Jalouka therapy was also given along with every week upto 12 weeks. The result of the combined therapy was encouraging without any side effects. Keyword- Mukhdushika, Jalouka, Herbo mineral compounds, Acne vulgaris
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M. Mikhael, Ehab, and Mahdi Y. Mohammed. "Serratiopeptidase a Hope in a Rapid and Better Improvement of Inflammatory Acne Vulgaris." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (March 28, 2017): 78–81. http://dx.doi.org/10.31351/vol21iss1pp78-81.

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Acne vulgaris is a very common, chronic disorder, involving inflammation of the pilosebaceous units that can be varied in presentation and difficult to treat. Inflammatory acne may yield both scarring and pigmentary changes so early and adequate therapy will, in all cases, decrease its severity and may entirely suppress this disease. Serratiopeptidase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation. Serratiopeptidase was added in aim to hasten acne resolution. During March to July 2010, A comparative study for a 50 healthy patient suffering from acne was divided into 2 groups: 1st group treated by common acne modalities and the 2nd one with same modalities plus serratiopeptidase. All patients were followed up in out patient clinic by a dermatologist after 1st week of treatment and once weekly through the period of treatment. The results of this study showed that the effect of serratiopeptidase as adjuvant therapy for acne treatment result in a significant rapid improvement, this might be explained by serratiopeptidase ability in enhancing antibiotic efficacy and also increase the possibility of excellent improvement in acne appearance which may be due of it’s anti-inflammatory, anti-edemic. Serratiopeptidase was found to create a good hope as additional therapy for complicated acne vulgaris and bring a rapid and better improvement in treating acne. Key words: Acne ,Serratiopeptidase.
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Barinova, Anna N. "Modern methods of treatment and rehabilitation of patients with acne vulgaris." Russian Family Doctor 22, no. 4 (December 15, 2018): 5–18. http://dx.doi.org/10.17816/rfd201845-18.

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The article reviews contemporary data on diagnosis and management of acne. Special attention is paid to differential diagnosis of acne and treatment of acne-like disorders. The contemporary approaches to the acne therapy are described in detail with special attention paid to the systemic treatment with hormonal contraceptives, isotretionin, antibiotics and systemic corticosteroids. The algorithms of acne management are given and also recommendations on prevention of relapses are provided.
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Afshari, Niloofar, Mehdi Amirnia, Davod Ahmadi, Saeed Kashefi, and Vahideh Aghamohammadi. "Comparing the efficacy of intense pulsed light combined with oral azithromycin versus oral azithromycin alone in the treatment of moderate to severe papulopustular acne vulgaris." Medical Journal of Tabriz University of Medical Sciences and Health Services 42, no. 6 (February 24, 2021): 621–26. http://dx.doi.org/10.34172/mj.2021.001.

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Background: Rising follicular keratin secretion, increasing sebum production, and Propionibacterium acnes are among the main etiology of acne vulgaris formation. Antibiotics are the predominant conventional treatment of acne. Antibiotic resistance is the main problem in the ordinary treatments of acne. Therefore, newer treatments are necessary. Intense pulsed light (IPL) is a novel therapeutic option with rapid application in this field. Methods: Patients referred to us were randomized into two groups: group A (cases) and group B (controls). In addition to conventional antibiotic therapy, IPL was prescribed to group A while azithromycin alone was prescribed to group B. IPL treatment was performed weekly for five weeks and the patients were followed for three months. Declining inflammatory lesions count after the intervention was considered the remission scale. Results: In group A, moderate, partial, and complete remission occurred in 4, 9, and 7 patients, respectively. In group B, moderate, partial, and complete remission occurred in 10, 7, and 3 patients, respectively. Statistically, the remission difference was meaningful between the two groups. Conclusion: IPL with conventional antibiotics is an effective treatment choice in moderate to severe acne vulgaris but also is a more accelerating agent in treatment versus antibiotics alone.
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De Resende, Luísna Gabriela Aguiar Lobo, Gabriel Cardoso Oliveira da Silva, and Erica Carvalho Caldas. "O Impacto Psicossocial da Acne Vulgar / The Psychosocial Impact of Acne Vulgaris." ID on line. Revista de psicologia 15, no. 58 (December 30, 2021): 351–67. http://dx.doi.org/10.14295/idonline.v15i58.3320.

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A acne é uma afecção cutânea comum, que atinge cerca de 80% da população em alguma fase da vida. Além da parte estética, a acne abrange consequências psicológicas e sociais que podem afetar a qualidade de vida, saúde psíquica e a autoestima dos pacientes. O presente estudo de revisão narrativa bibliográfica, investigou os aspectos principais do impacto psicossocial em pessoas com acne vulgar. Constatou-se que vários danos são gerados para os acometidos por essa patologia, entre eles estão: ansiedade, fobia social, depressão, insegurança, timidez, sintomas obsessivos compulsivos e transtorno dismórfico corporal. Tendo em vista os resultados apontados, confirmou-se que o tratamento adequado e efetivo apresenta grande melhora no quadro dos pacientes. Diante dos malefícios que a acne promove para vida da população é necessário compreendê-la como uma doença e não apenas como uma disfunção estética. ---Acne is a common skin condition that affects about 80% of the population at some stage of life. In addition to the aesthetic part, acne includes psychological and social consequences that can affect the quality of life, mental health, and self-esteem of patients. The present study of a bibliographic narrative review investigated the main aspects of the psychosocial impact on people with acne vulgaris. It was found that several damages are generated for those affected by this pathology, including anxiety, social phobia, depression, insecurity, shyness, obsessive-compulsive symptoms and body dysmorphic disorder. In view of the above results, it was confirmed that the adequate and effective treatment presents a great improvement in the patients' condition. In view of the harm that acne causes to the population's life, it is necessary to understand it as a disease and not just an aesthetic dysfunction.
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ELMAN, MONICA, and JOSEPH LEBZELTER. "Light Therapy in the Treatment of Acne Vulgaris." Dermatologic Surgery 30, no. 2 (February 2004): 139–46. http://dx.doi.org/10.1097/00042728-200402000-00005.

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