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Dissertations / Theses on the topic 'ACML'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

FONTANA, DILETTA. "Characterization of the role of mutated ETNK1 in the onset of atypical Chronic Myeloid Leukemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241117.

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La leucemia mieloide cronica atipica (aCML) è un disordine clonale appartenente al gruppo delle sindromi mielodisplastiche/mieloproliferative (MDS/MPN). Circa il 13% dei casi di aCML è caratterizzato dalla presenza di mutazioni somatiche a carico del gene ETNK1, codificanti per le sostituzioni amminoacidiche H243Y, N244S e G245V. Precedentemente, abbiamo dimostrato che sia in campioni primari di aCML ETNK1-positiva sia nella linea cellulare TF1 trasdotta con ETNK1 mutato, le mutazioni causano una diminuzione dell’attività enzimatica di ETNK1, causando una riduzione nei livelli intracellulari d

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2

KHANDELWAL, PRAVEEN. "Elucidating the oncogenic role of genetic events in BCR-ABL1 positive chronic myeloid leukemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/99449.

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In hematological myeloid malignancies the accumulation of oncogenic events plays a significant role in disease progression. Therefore, in this work, we studied (i) the mutational landscape in typical chronic myeloid leukemia (CML) patients and (ii) the neoplastic role of Setbp1 mutation in atypical chronic myeloid leukemia (aCML). 1) We evaluated somatic variants in CML patients by Next Generation Sequencing, to study the molecular pathogenesis of cancer. We conducted a mutational analysis on 23 chronic phase BCR-ABL1+ CML patients through exome and RNA sequencing performed on diagnosis samp

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3

PERONACI, MARCO. "Characterization of new oncogenes identified through NGS-based analysis of leukemias: SETBP1 and ETS2-ERG." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/144663.

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In the past years, the improvements in sequencing technology led to the development of “Next Generation Sequencing” (NGS) technologies. Several NGS approaches exist. Whole genome sequencing (WGS) and whole exome sequencing (WES) allow the identification of genomic alterations such as small insertions/deletions, point mutations and structural variants. Whole transcriptome sequencing (RNA-Seq) permits to quantify gene expression profiles and to detect alternative splicing and fusion transcripts. Recently, by using WES on atypical chronic myeloid leukemia (aCML) samples, our group identified recu

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4

VALLETTA, SIMONA. "Recurrent SETBP1 mutations in atypical chronic myeloid leukemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50227.

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Atypical chronic myeloid leukemia (aCML) is a heterogeneous disorder belonging to the group of myelodysplastic/myeloproliferative (MDS/MPN) syndromes. aCML shares clinical and laboratory features with Chronic Myeloid Leukemia (CML), but it lacks the Philadelphia chromosome and the resulting BCR-ABL fusion gene. This crucial difference with CML points to a different pathogenetic process. Because no specific recurrent genomic or karyotypic abnormalities have been identified in aCML, and the molecular pathogenesis of this disease has remained elusive with a dismal outcome, we performed exome-sequ

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5

Souza, Clarice de Azevedo. "The Acyl-CoA ligase-like (ACLL) gene family in Arabidopsis and poplar." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31283.

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Many genes of unknown function have been annotated in plant genome projects, and many of these may encode undiscovered enzymes. For example, completion of the Arabidopsis thaliana genome sequence revealed large families of phenylpropanoid-like enzymes of unknown functions. Using an in silico similarity search based on the amino-acid sequences of known Arabidopsis genes encoding 4-coumarate:CoA ligase (4CL), I identified nine putative genes as members of the Arabidopsis acyl-CoA ligase-like (ACLL) gene superfamily which encode a plant-specific clade of enzymes closely related to true 4CLs. I al

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6

Pomini, Armando Mateus. "Acil-homosserina lactonas produzidas pelas bacterias fitopatogenicas Pantoea ananatis e Methylobacterium mesophilicum e defesa quimica no opilião Hoplobunus mexicanus." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249296.

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Orientador: Anita Jocelyne Marsaioli<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-13T13:06:45Z (GMT). No. of bitstreams: 1 Pomini_ArmandoMateus_D.pdf: 4501241 bytes, checksum: 249f7514962993874b22ddcad9831cc8 (MD5) Previous issue date: 2009<br>As bactérias Gram-positivas e Gram-negativas possuem um mecanismo de comunicação química intra-específico conhecido como ¿quorum-sensing¿, regulando a expressão de uma vasta gama de atividades biológicas. As bactérias Gram-negativas utilizam acil-homosserina lactonas (acil-HSLs) co

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7

Costa, Bruna Vieira de Lima. "Consumo de carnes e derivados e fatores associados ao estado nutricional de idosos em instiruição de longa permanência de Belo Horizonte - MG." Universidade Federal de Minas Gerais, 2009. http://hdl.handle.net/1843/ACSL-7YAQLW.

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Sectional study, to identify the consumption of meat and meat products of elderly residents in geriatric institution of Belo Horizonte. Random sample (n = 52). Nutritional assessment was made by anthropometry, dietary and MAN. The process of acquisition, receipt, storage, handling of meat and meat products was observed. Was also carried out a cohort study to determine the anthropometric development. The results showed the need to reassess the process of buying, receiving and preparation of foodstuffs since there was a delivery of meat inappropriate amount and form of receipt, which contributed

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8

Teodoro, Bruno Gonzaga. "Função da Acil-CoA Sintetase 6 no metabolismo de músculo esquelético de ratos e humanos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-29082016-100827/.

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Cinco membros da família das Acil-CoA sintetases de cadeia longa (ACSL) são responsáveis por ativar ácidos graxos, produzindo acil-CoA, e distribuí-los entre diversas vias metabólicas no interior da célula, tais como a síntese de triacilglicerol (TAG) e ?- oxidação mitocondrial. Apesar das disfunções nas ACSLs contribuirem para muitas doenças metabólicasa função de algumas isoformas de ACSL em tecidos específicos permanece ainda sem descrição na literatura. Aqui mostramos pela primeira vez a presença de mRNA da ACSL6 no músculo esquelético de seres humanos. Além disso, indivíduos obesos aprese

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9

Al-Faiyz, Yasair S. S. "The chemistry of O-acyl derivatives of N-acyl hydroxamic acid." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252534.

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10

Chalfoun, David Joseph. "Acyl transfer to lysine : an investigation acyl transfer across large rings." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/38769.

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11

Chrystiuk, E. "Acyl group transfer mechanisms." Thesis, University of Kent, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374300.

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12

Miranda, Anabela Medo. "Mycobacterial acyl-CoA carboxylases." Thesis, University of Surrey, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298085.

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13

Cardoso, Ariel Rodrigues. "Geração de espécies reativas de oxigênio (ERO) mitocondriais: papel das Acil-CoA desidrogenases de cadeia muito longa." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-23012015-134052/.

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Dietas hiperlipídicas e a esteatose hepática são condições extremamente prevalentes. Trabalhos anteriores mostraram que a esteatose está associada a um aumento na geração de espécies reativas de oxigênio (ERO), e que isso pode mediar danos no fígado. Neste trabalho nós investigamos os possíveis mecanismos que desencadeiam os aumentos nas taxas de geração de ERO por meio da administração de dietas hiperlipídicas. Nós descobrimos que mitocôndrias de animais sujeitos a dietas hiperlipídicas não apresentaram diferenças significativas quanto a capacidade respiratória máxima e acoplamento, mas eram

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14

Bromley, L. A. "Iron acyl complexes in synthesis." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237924.

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15

Kenny, Jane Ruth. "An investigation of acyl glucuronides." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269597.

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16

Levy, Esther Gillian. "Porphyrin-catalysed acyl transfer reactions." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627031.

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17

Ioakem, Nicolle. "Acme Tool 2.0 Software Manual." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/245076.

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18

Idnani, Sunil Charan 1964. "An ACSL interface for DYMOLA." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/291863.

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This MS thesis proposes the use of DYMOLA, an object-oriented language for modeling hierarchically structured systems, to generate ACSL simulation programs for continuous system analysis. An ACSL model described in terms of time dependent non-linear differential equations or transfer functions can be generated from a hierarchical model description of the system using DYMOLA. The model description in DYMOLA can be an equation description or a non-linear hierarchical bond graph abstraction to describe the system under investigation. The interface provides an automated method to generate ACSL sim

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19

Jesus, Jacqueline Cristina Bueno Janice de. "Síntese e caracterização espectroscópica de complexos tris -dicetonatos do íon európio com ligantes 2-(n-acil)-piridina." Universidade Federal da Paraíba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/7153.

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Made available in DSpace on 2015-05-14T13:21:40Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2137261 bytes, checksum: 13b9e74375fe86c1b2772dad6188a007 (MD5) Previous issue date: 2014-06-20<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>In this work, we propose a new class of complexes of trivalent europium ion derived from tetrakis-diketonates, by replacing the keto group of a ligand by the 2- aminopyridyl. For the synthesis of these complexes, the amides N-acetyl-2- aminopyridine and N-trifluoroacetyl-2-aminopyridine were prepared via acylation of 2- amino

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20

Conocimiento, Dirección de Gestión del. "ACM Digital Library." Asociación de Maquinaria de Computación, 2004. http://hdl.handle.net/10757/655259.

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21

Reis, Barbaros. "Addition Of Acyl Phosphonates To Ethylcyanoformate." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/2/12609090/index.pdf.

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Functionalized cyanophosphates are important starting materials for the synthesis of beta-lactam ring moiety of beta-lactam antibiotics. The cyanophosphates are synthesized starting from easily available acylphosphonate and ethylcyanoformate. Acylphosphonates are synthesized starting from acylchloride and trimethylphosphite. Addition of acylphoshonate to ethylcyanoformate furnishes the cyanophosphate with the quaternary center.

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22

Walker, Jonathan Charles. "Asymmetric synthesis via iron acyl complexes." Thesis, University of Oxford, 1986. http://ora.ox.ac.uk/objects/uuid:55cfc478-5868-474f-9d2b-532218ec6fd6.

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23

Aman, Ahmed M. "Studies of amide acyl transfer reactions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0028/NQ38297.pdf.

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24

Wills, M. "Synthetic application of iron acyl complexes." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235128.

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25

Easton, R. J. C. "Stereoselective synthesis via iron acyl complexes." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379991.

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26

Ayscough, A. P. "Stereoselective synthesis using iron acyl complexes." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234993.

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27

Preston, Simon Christopher. "Asymmetric synthesis via iron acyl complexes." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236153.

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28

Fraser-Bell, G. "Asymmetric synthesis via iron acyl compounds." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329923.

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29

Penman, June. "GPR55 and N-acyl amino acids." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/2e07c280-3a61-4f49-a9da-1fa4ffc79fa5.

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G-protein coupled receptor 55 (GPR55) is a novel lipid sensing receptor activated by the endogenous lipid, lysophosphatidylinositol (LPI) and is reported as a putative cannabinoid receptor. However GPR55 shares limited homology with the two cloned cannabinoid receptors (CB<sub>1</sub> and CB<sub>2</sub>) but does exhibit some cannabinoid sensitivity. Recently a family of bioactive lipids, the N-acyl amino acids, are gaining interest due to their structural similarity to endocannabinoids (naturally occurring CB<sub>1</sub> and CB<sub>2</sub> agonists). N-acyl amino acids have little or no affin

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30

Wallace, Paul Neil. "Acyl transfer reactions of diphenylphosphine oxides." Thesis, University of Cambridge, 1986. https://www.repository.cam.ac.uk/handle/1810/270447.

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31

Bailey, Mark J. "Acyl glucuronide reactivity : some biological consequences /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16205.pdf.

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32

Othman, Abrizah. "Isolation and characterisation of an acyl-acyl carrier protein (ACP) thioesterase gene from the oil palm (Elaeis guineensis)." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404314.

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33

Poderi, Cecilia. "Synergistic catalysis: Michael addition of acyl-pyridines." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14409/.

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A new diastereo- and enantioselective strategy for the functionalization of 2-acetyl-pyridine with α,β-unsaturated aldehydes has been investigated through synergistic catalysis. In particular, the aim of the work was to use cinnamaldehydes bearing different substituents on the phenyl group and to study its effect on the yield, conversion and stereoselectivity of the reaction. The reaction mechanism involves combined iminium ion and transition metal catalysis in a synergistic fashion and proceeds with two consecutives Michael additions, followed by final intramolecular aldol condensation to yie

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34

Sevim, Ilhan. "Reactions Of Diethylaluminum Cyanide With Acyl Phosphonates." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12611557/index.pdf.

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This thesis includes reaction of diethylaluminum cyanide with acyl phosphonates. Cyanohidrin O-phosphates are synthesized from easily available acyl phosphonates and diethylaluminum cyanide. Synthesis of cross-benzoin product of acyl phosphonate, &amp<br>#945<br>-hydroxy phosphonate and tertiary carbinol are synthesized from the reaction of diethylaluminum cyanide with acyl phosphonates, representatively. Asymmetric syntheses of cyanohydrin and benzoin type reaction of acyl phoshonate are also investigated representatively.

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35

Wang, Xueqing. "Oxidative cyclization of phenolic N-acyl sulfonamides." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61303.

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The oxidative activation of appropriately substituted phenols with a hypervalent iodine reagent, in the presence of suitable nitrogen nucleophiles, results in formation of 2- or 4-amidodienones. The process is described as the oxidative amidation of phenols. The dienones thus produced are useful building blocks for the synthesis of alkaloids. The nitrogen nucleophile may be an oxazoline, a sulfonamide or phosphoramide (intramolecular reactions), or a nitrile (bimolecular reaction), but not a carboxamide. This is because carboxamides express Onucleophilicity toward oxidatively activated phenols

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36

Doran, John D. "Raman spectroscopic studies of acyl cysteine proteases." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9624.

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For a series of acyl cysteine proteases structure-reactivity relationships for the deacylation step have been established using a combination of Raman and absorption spectroscopies and enzyme kinetics. The simple chromophoric ligand 5-methylthienylacryloyl- (5MTA-) and three novel peptide based substrates labelled with the 5MTA- moiety, were used to create acyl enzyme adducts with papain, cathepsin B, cathepsin L, and protein engineered mutants of cathepsins B and L. The chromophoric specific substrates, 2-Ethoxycarbamido-3-(5-methylthienyl)acryloyl ethyl ester (NHCOOEt5MTAEt), 2-(N-acetyl-L-a

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37

Obuchowska, Agnes K. "Acyl transfer in chemical synthesis of oligosaccharides." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34056.pdf.

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38

Hellenbrand, Janine [Verfasser]. "Charakterisierung von Acyl-CoA-Reduktasen / Janine Hellenbrand." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2012. http://d-nb.info/1022733494/34.

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39

Beattie, Stuart Gavin. "Lecithin colesterol ACYL transferase gene transfer studies." Thesis, Royal Holloway, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409233.

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40

Warner, P. "Asymmetric synthesis via transition metal acyl complexes." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355823.

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41

Simonian, Houri. "Acyl radical mediated polyene cyclisations in synthesis." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307815.

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42

Luthra, A. K. "Some studies of acyl-group transfer reactions." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332147.

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43

Maddaford, Adrian. "Studies toward an enantioselective acyl transfer catalyst." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324425.

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44

Klair, Sukhbinder S. "Stereoselective enolate alkylation of acyl dithiane oxides." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314512.

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45

Fraser, Thomas Colin Michael. "Characterisation of sunflower lysophosphpatidylcholine Acyl-CoA acyltransferase." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238923.

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46

Atkinson, Benjamin. "Metal catalysed acyl transfer reactions of amides." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665412.

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The following thesis outlines work carried out during the last three years for the development and investigation of methodologies using amides as N- and O- acylating agents. Chapter 1 highlights the range of methodologies and protocols reported in the literature that use amides as precursors for the synthesis of both functionalised amides and esters. The introduction will highlight the range of catalysts and promoters used as well as the scope of the current methodologies. As well as this it will highlight the limitations of the methodologies so emphasising where the following research fits in

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47

Chhatwal, Amarjit. "Novel approaches to catalytic acyl transfer reactions." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665422.

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48

Tyler, Lydia Justine. "Chemical reactions of an acyl carrier protein." Thesis, University of Cambridge, 1996. https://www.repository.cam.ac.uk/handle/1810/272174.

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49

AIT, MANSOUR HAMID. "Recherches dans la serie des acyl-6 benzoxazolinones : metabolites de la benzoyl-6 benzoxazolinone et pharmacomodulation des derives halogenoacyles." Lille 2, 1991. http://www.theses.fr/1991LIL2T007.

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50

AICHAOUI, HOCINE. "Acyl benzoxazolinones et produits de transformation : synthese, structure et proprietes pharmacologiques." Lille 2, 1991. http://www.theses.fr/1991LIL2T001.

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