Journal articles: 'Acidi succinici'

1

Jung, Yui Jung. "The Influence of Organic Acid on Color Retention after Dyeing - Focusing on succinic acid and tartaric acid." Journal of Health and Beauty 16, no. 2 (August 31, 2022): 163–72. http://dx.doi.org/10.35131/ishb.2022.16.2.163.

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Levchyck, N. Ya. "BIOLOGICAL ACTIVITY OF SUCCINIC ACIDS." Biotechnologia Acta 10, no. 6 (December 2017): 53–60. http://dx.doi.org/10.15407/biotech10.06.053.

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Lee, Jae Young, and Lynn M. Hildemann. "Comparisons between Hygroscopic Measurements and UNIFAC Model Predictions for Dicarboxylic Organic Aerosol Mixtures." Advances in Meteorology 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/897170.

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Hygroscopic behavior was measured at 12°C over aqueous bulk solutions containing dicarboxylic acids, using a Baratron pressure transducer. Our experimental measurements of water activity for malonic acid solutions (0–10 mol/kg water) and glutaric acid solutions (0–5 mol/kg water) agreed to within 0.6% and 0.8% of the predictions using Peng’s modified UNIFAC model, respectively (except for the 10 mol/kg water value, which differed by 2%). However, for solutions containing mixtures of malonic/glutaric acids, malonic/succinic acids, and glutaric/succinic acids, the disagreements between the measurements and predictions using the ZSR model or Peng’s modified UNIFAC model are higher than those for the single-component cases. Measurements of the overall water vapor pressure for 50 : 50 molar mixtures of malonic/glutaric acids closely followed that for malonic acid alone. For mixtures of malonic/succinic acids and glutaric/succinic acids, the influence of a constant concentration of succinic acid on water uptake became more significant as the concentration of malonic acid or glutaric acid was increased.

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Kang, In-Sook, and Hyun-Sook Bae. "Mechanical Properties of Cotton Fabric Treated with Succinic Acid - Tear Strength -." Textile Coloration and Finishing 21, no. 3 (June 27, 2009): 1–9. http://dx.doi.org/10.5764/tcf.2009.21.3.001.

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Dey, Swapan, Dibyendu Sain, Ashish Kumar, and Chanda Kumari. "A series of ditopic receptors for succinic acid binding." RSC Adv. 4, no. 93 (2014): 51486–95. http://dx.doi.org/10.1039/c4ra07537d.

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Three ditopic-abiotic receptors (R1, R2 and R3) have been designed and synthesised. The receptors have been applied for the recognition of dicarboxylic acids viz. malonic, succinic, glutaric and adipic acids. Among them, succinic acid shows the highest binding efficiency to all receptors. Recognition of succinic acid is very important due to its various adverse effects on human health upon prolonged exposure.

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Kvaratskhelia, E., and R. Kurtanidze. "THE ELECTROLYTIC DISSOCIATION OF METHYLENE SUCCINIC ACID." Chemical Problems 17, no. 3 (2019): 408–12. http://dx.doi.org/10.32737/2221-8688-2019-3-408-412.

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Lee, Sang Jun, Hyohak Song, and Sang Yup Lee. "Genome-Based Metabolic Engineering of Mannheimia succiniciproducens for Succinic Acid Production." Applied and Environmental Microbiology 72, no. 3 (March 2006): 1939–48. http://dx.doi.org/10.1128/aem.72.3.1939-1948.2006.

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ABSTRACT Succinic acid is a four-carbon dicarboxylic acid produced as one of the fermentation products of anaerobic metabolism. Based on the complete genome sequence of a capnophilic succinic acid-producing rumen bacterium, Mannheimia succiniciproducens, gene knockout studies were carried out to understand its anaerobic fermentative metabolism and consequently to develop a metabolically engineered strain capable of producing succinic acid without by-product formation. Among three different CO2-fixing metabolic reactions catalyzed by phosphoenolpyruvate (PEP) carboxykinase, PEP carboxylase, and malic enzyme, PEP carboxykinase was the most important for the anaerobic growth of M. succiniciproducens and succinic acid production. Oxaloacetate formed by carboxylation of PEP was found to be converted to succinic acid by three sequential reactions catalyzed by malate dehydrogenase, fumarase, and fumarate reductase. Major metabolic pathways leading to by-product formation were successfully removed by disrupting the ldhA, pflB, pta, and ackA genes. This metabolically engineered LPK7 strain was able to produce 13.4 g/liter of succinic acid from 20 g/liter glucose with little or no formation of acetic, formic, and lactic acids, resulting in a succinic acid yield of 0.97 mol succinic acid per mol glucose. Fed-batch culture of M. succiniciproducens LPK7 with intermittent glucose feeding allowed the production of 52.4 g/liter of succinic acid, with a succinic acid yield of 1.16 mol succinic acid per mol glucose and a succinic acid productivity of 1.8 g/liter/h, which should be useful for industrial production of succinic acid.

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N, Hema, and K. P. Sreenath. "Screening for Isolation of Succinic Acid Producing Microbes." Biosciences, Biotechnology Research Asia 15, no. 2 (June 7, 2018): 327–33. http://dx.doi.org/10.13005/bbra/2636.

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Succinic acid has emerged as one of the most competitive bio-based chemicals. Present study intended to isolate potential strains for the production of succinic acid. More than 90 isolates were obtained from various sources using anaerobic techniques. All the strains were screened for succinic acid production through bromocresol green media, thin layer chromatography and HPLC methods. 74 isolates showed colour change in bromocresol green media indicating the production of organic acids, of which 14 isolates showed succinic acid production determined by thin layer chromatography which were quantified through HPLC. The isolates which yielded succinic acid ranged from 0.24g/l (MGC) to 4.69g/l (RFC-P3).

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Mello, Karine Gargioni Pereira Correa de, Leandra de Cássia Bernusso, Ronaldo Nogueira de Moraes Pitombo, and Bronislaw Polakiewicz. "Synthesis and physicochemical characterization of chemically modified chitosan by succinic anhydride." Brazilian Archives of Biology and Technology 49, no. 4 (July 2006): 665–68. http://dx.doi.org/10.1590/s1516-89132006000500017.

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The N-succinil-chitosan is a chemically modified derivative of the biopolymer chitosan. The succinic anhydride attached to the free amino groups presented along the chitosan's polymer chain imparts to the molecule different physicochemical properties not exhibited before the modification. These chemical modifications enhance chitosan's solubility in slightly acid, neutral and alkaline media. These properties are related to the long alkyl chains attached to hydrophilic parts. In this case the hydrophilic part of D-glucosamine promotes stronger interactions with the water molecules, and consequently, enhances the solubility of the chitosan polymer. Non-modified free chitosan is soluble only in acidic medium (pH < 5.5). These modifications made possible new applications of chitosan in biotechnological area since the solubility in neutral or slightly alkaline solutions is very important in a biological field.

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OH, MYEONGGEUN, JOONGJAE LEE, YOONHWA JEONG, and MISOOK KIM. "Synergistic Antilisterial Effects of Mixtures of Lysozyme and Organic Acids." Journal of Food Protection 79, no. 12 (December 1, 2016): 2184–89. http://dx.doi.org/10.4315/0362-028x.jfp-16-156.

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ABSTRACT We investigated the synergistic effects of lysozyme combined with organic acids to inhibit the growth of Listeria monocytogenes. The antilisterial effects of the combination of lysozyme and acetic acid, citric acid, lactic acid, malic acid, or succinic acid were evaluated using the checkerboard method and time-kill assay. The MIC was 25,000 mg/liter for lysozyme, 625 mg/liter for acetic acid, and 1,250 mg/liter for the other acids. The MBC was 10,000 mg/liter for all of the tested organic acids. The combination of lysozyme and each organic acid showed synergistic effects via the checkerboard method; however, the time-kill assay showed synergistic effects for only three combinations of 1,250 mg/liter lysozyme with succinic acid (312 and 625 mg/liter) or malic acid (625 mg/liter). The results of this study indicate that the combination of lysozyme and malic acid or succinic acid can be effectively used as a food preservative to control L. monocytogenes.

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Tukumova, Natalia V., Tatiana R. Usacheva, Tran Thi Dieu Thuan, Valentin A. Sharnin, and Concetta Giancola. "STABILITY OF COORDINATION COMPOUNDS OF SOME d-METAL IONS WITH SUCCINIC ACID ANION IN AQUEOUS-ETHANOL SOLVENTS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 61, no. 9-10 (October 22, 2018): 15–22. http://dx.doi.org/10.6060/ivkkt20186109-10.5778.

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The paper provides an overview of own data on complexation of nickel (II), cobalt (II) and cooper (II) ions with succinic acid anion in water-organic mixed solvents. Proper data are compared with data reported in literature for d-metal complexes with anions of maleic and succinic acids. The effect of aqueous ethanol solvent compositions on the stability of coordination compounds of M2+ with succinic acid anion as well as on рК values of stepwise succinic acid dissociation was carried out by a potentiometric titration at ionic strength of 0.1 maintained with sodium perchlorate at 298.15 ± 0.10 K. Mono ligand complexes of Ni2+, Co2+ and Cu2+ ions with succinic acid anion become stronger when ethanol content rises. In aqueous solutions Cu2+ ion forms stronger complexes with succinic and maleic acid anions than Ni2+ and Co2+ ions. In the studied water - ethanol solution this ratio is maintained for complexes with succinic acid anion, but a water-isopropanol solvent exerts leveling effect on the stability of complexes of nickel (II) and cobalt (II). An increase in the stability of complexes of d-metal with anions of maleic and succinic acids is due to the destabilization of the ligand with increasing ethanol concentration. The principal contribution of the changes in the solvation state of ligand is a typical for the stability changes of d-metal complexes with amine, glycinate, and acetate type ligands in water-organic mixed solvents. For citation: Tukumova N.V., Usacheva T.R., Thuan Tran Thi Dieu, Sharnin V.A., Giancola C. Stability of coordination compounds of some d-metal ions with succinic acid anion in aqueous-ethanol solvents. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2018. V. 61. N 9-10. P. 15-22

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12

Ehlenfeldt, Mark K., Filmore I. Meredith, and James R. Ballington. "Unique Organic Acid Profile of Rabbiteye vs. Highbush Blueberries." HortScience 29, no. 4 (April 1994): 321–23. http://dx.doi.org/10.21273/hortsci.29.4.321.

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The fruit of six highbush (Vaccinium corymbosum L.) cultivars and eight rabbiteye (V. ashei Reade) cultivars and selections were evaluated by high-performance liquid chromatography for levels of the commonly found organic acids, citric, malic, succinic, and quinic. The two cultivar groups possessed distinctive patterns of relative organic acid proportions that could unambiguously separate pure rabbiteye and highbush clones in a principal component analysis. Highbush clones were characterized by high citric acid content, with percentages averaging 75% (range 38% to 90%). Succinic acid was the second most plentiful acid, averaging 17%. In contrast, rabbiteye cultivars and selections contained 10% citric acid, and no clone had >22%. Succinic acid and malic acid were found in greater quantities than in highbush, averaging 50% and 34%, respectively. Analysis of the fruit of seven albino-fruited highbush selections exhibited a profile similar to standard highbush cultivars, but with a citric acid average of <50%, and proportionally greater amounts of succinic and quinic acids. Given the differences in sensory quality of these four acids, it is likely that acid partitioning patterns can largely account for some of the perceived flavor differences between rabbiteye and highbush blueberries. Because several current breeding efforts involve hybridization between highbush and rabbiteye blueberries, a consideration of acid composition of breeding parents maybe worthwhile.

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Zhang, T. M., H. Jijakli, and W. J. Malaisse. "Nutritional efficiency of succinic acid and glutamic acid dimethyl esters in colon carcinoma cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 5 (May 1, 1996): G852—G859. http://dx.doi.org/10.1152/ajpgi.1996.270.5.g852.

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The dimethyl esters of succinic acid (SAD) and glutamic acid (GME) were found to be efficiently metabolized in colon carcinoma cells of the Caco-2 line. The rate of [1,4-14C]SAD and [2,3-14C]SAD conversion to radioactive acidic metabolites, CO2, amino acids, pyruvic acid, and lactic acid suggested that the catabolism of the ester-derived succinic acid occurred mainly through the sequence of reactions catalyzed by succinate dehydrogenase, fumarase, and the malic enzyme. This coincided with a marked sparing action of SAD on the utilization of D-[2-(3)H]glucose and D-[5-(3)H]glucose and generation of 14C-labeled acid metabolites, CO2, and lactic acid from D-[U-14C]glucose by the enterocytes. Likewise, the conversion of [U-14C]GME to 14C-labeled amino acids, its oxidation compared with that of [1-(14)C]GME, and the production of NH4+ in the absence or presence of GME indicated efficient catabolism of the latter ester. Like SAD, GME decreased the utilization of D-[5-(3)H]glucose and generation of 14C-labeled acidic metabolites, pyruvate, and CO2 from D-[6-(14)C]glucose, while increasing the generation of 14C-labeled amino acids from the labeled hexose. The oxidation of D-[6-(14)C]glucose was even more severely inhibited by GME. In normal rat intestinal cells, SAM, SAD, and GME also exerted a marked sparing action on D-[U-14C]glucose oxidation. The present findings suggest, therefore, that these esters could possibly be used to sustain ATP generation in intestinal cells.

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Beloborodova, N. V., I. T. Bairamov, A. Yu Olenin, and N. I. Fedotcheva. "Exometabolites of some anaerobic microorganisms of human microflora." Biomeditsinskaya Khimiya 57, no. 1 (January 2011): 95–105. http://dx.doi.org/10.18097/pbmc20115701095.

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Some exometabolites produced by basic representatives of human anaerobic microflora were investigated, detected by gas chromatography - mass spectrometry (GC-MS). In vitro besides lactic acid Bifidobacterium and Lactobacillus generate substantial amounts of phenyllactic and p-hydroxyphenyllactic acids. Clostridium produced 2-hydroxybutyric acid and to a lesser extent lactic and phenyllactic acids. In contrast to С. perfringens, C. sporogenes generates substantial amount of phenylpropionic and p-hydroxyphenylpropionic acids and less p-hydroxyphenyllactic acid. С. perfringens produced minor amounts of 2-hydroxyglutaric acid. Bacteroids are potent producers of succinic and fumaric acids; they also contribute to production of significant portion of lactic acid. E. lentum generate lactic, phenyllactic and succinic acids and form a characteristic only for ones (from studied microorganisms) 2-hydroxyhexanic and 2-hydroxy-3-methylbutyric acids.

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Parenteau, Lucie, and François Brisse. "Structure of the stoichiometric complex 18-crown-6•H2O•succinic acid." Canadian Journal of Chemistry 67, no. 8 (August 1, 1989): 1293–97. http://dx.doi.org/10.1139/v89-197.

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Attempts to prepare stoichiometric complexes of the type dicarboxylic acid•18C6•H2O succeeded only with oxalic, succinic, and glutaric acids. The crystal structure of the succinic acid complex was established by X-ray diffraction at 173 K, and was refined to Rw = 0.038 for 3204 observed reflections. The stoichiometry of the complex is 1:1:1 (succinic acid•H2O•18C6). In the solid state there is a dimeric H-bonded association, through a center of symmetry, of two succinic acid molecules. Each diacid is also hydrogen bonded to a water molecule. The water molecules, in turn, form two hydrogen bonds each with the crown ether. The diacid–diacid, diacid–water, and the two water–18C6 hydrogen bonds are 2.657(2), 2.636(2), 2.819(2), and 2.910(2) Å long respectively. They are all nearly linear. The structural units are associated and form the centrosymmetric dimer (18C6–H2O–succinic acid)2. The conformation of the macrocyclic polyether differs significantly from that normally found. Instead of the usual (ttg)6 conformation, that adopted in this complex is (ttgttgstg)2. The two s torsion angles have values of 90.1(3) and 86.9(3)°. In this complex the succinic acid itself is in the gauche conformation. Keywords: macrocycle – succinic acid complex.

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Ramli, Nazatul Aziqah, Masturah Markom, and Abdullah Amru Indera Luthfi. "Production and Recovery of Succinic Acid from Oil Palm Frond (OPF) Fermentation." Journal of Biochemistry, Microbiology and Biotechnology 10, SP2 (December 26, 2022): 57–60. http://dx.doi.org/10.54987/jobimb.v10isp2.729.

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This study aimed to determine the production of succinic acid by using different nitrogen sources in oil palm frond (OPF) fermentation and the recovery of succinic acid. A comparison between two nitrogen sources, i.e., yeast extract and peptone, was performed and a fermentation solution containing the highest concentration of succinic acid was used to carry out the recovery process. Activated carbon treatment at 4% to 6% (w/w) was performed to determine the best dosage that could be used for the recovery of succinic acid in the fermentation solution. Based on the results obtained, it was found that yeast extract was able to produce a higher concentration of succinic acid at 2.62 g/L with a yield of 1.53 g/g, compared to peptone which afforded a concentration of 1.89 g/L with a yield of 1.10 g/g. It was also found that the dose of 5% (w/w) activated carbon was the best to increase the concentration of succinic acid and adsorb other organic acids. After the activated carbon was fed into the fermentation solution, it was found that the succinic acid content increased from 2.62 g/L to 3.43 g/L with a percentage increase of 24.7%.

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Torres-Guardado, Rafael, Nicolas Rozès, Braulio Esteve-Zarzoso, Cristina Reguant, and Albert Bordons. "Influence of succinic acid on <i>Oenococcus oeni</i> and malolactic fermentation." OENO One 56, no. 3 (August 3, 2022): 195–204. http://dx.doi.org/10.20870/oeno-one.2022.56.3.5403.

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As a consequence of the alcoholic fermentation carried out by yeasts in wine, several compounds can be delivered to the medium, promoting or inhibiting the malolactic fermentation (MLF) and the lactic acid bacteria, mainly Oenococcus oeni. Succinic acid is one of these compounds and is an example of the interaction between yeasts, including non-Saccharomyces species, and O. oeni. However, the influence of succinic acid on the MLF has been researched very little as yet. In this work, we study the influence of succinic acid and pH on O. oeni CH11 and PSU-1 strains, both during MLF and in resting cell experiments. Moreover, we analysed the relative expression of some significant genes related to stress and malolactic activity to determine how the O. oeni strains were affected by the succinic acid. The results showed that the succinic acid could act as an MLF inhibitor at concentrations higher than 1 g/L, but it can be beneficial at 0.5 g/L. This variable effect also depends on the strains and other winemaking conditions, mainly pH, which influences the dissociated and undissociated forms of both acids. The inhibiting effect of succinic seems clearer when it is at a molar concentration higher than that of L-malic acid. Experiments with resting cells have confirmed that O. oeni consumes less L-malic acid when succinic acid is higher than 1 g/L. Genetic expression experiments showed that in the presence of succinic acid (2 g/L), gene hsp18 encoding stress protein was up-regulated in strain CH11, suggesting a good response and adaptation of this strain to stress. On the other hand, genes mleA and mleP, which are related to malolactic activity, were not affected by succinic acid, except for strain PSU-1 at pH 4.0. Further research is necessary to understand better the effects of succinic acid on O. oeni and MLF.

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Cascaval, Dan, Anca-Irina Galaction, and Corneliu Oniscu. "Modeling of the selective pertraction of carboxylic acids obtained by citric fermentation." Chemical Industry 58, no. 3 (2004): 97–103. http://dx.doi.org/10.2298/hemind0403097c.

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Facilitated pertraction was applied for the selective separation of citric, maleic and succinic acids from a mixture obtained by citric fermentation. The pertraction equipment included a U-shaped cell containing 1,2-dichloro-ethane as the liquid membrane and Amberlite LA-2 as the carrier. The experimental data indicated that maleic and succinic acids can be initially selectively separated from citric acid, followed by the selectively separation of maleic acid from succinic acid. Using statistical analysis and a second order factorial experiment, two mathematical correlations describing the influence of the main process variables on pertraction selectivity were established. For both extraction systems, the considered variables controlled the extraction process to an extent of 92.9-99.9%, the carrier concentration inside the liquid membrane exhibiting the most important influence.

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Fatullayeva, P. A. "COMPLEXES OF METALS WITH DIHYDRAZONES OF SUCCINIC ACID DIHYDRAZIDE." Chemical Problems 17, no. 4 (2019): 558–64. http://dx.doi.org/10.32737/2221-8688-2019-4-558-564.

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COSMULESCU, Sina N., Ion TRANDAFIR, Flavia SCRIECIU, and Ana-Maria STOENESCU. "Content in organic acids of Mespilus spp. and Crataegus spp. genotypes." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 48, no. 1 (March 31, 2020): 171–76. http://dx.doi.org/10.15835/nbha48111746.

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Medlar and hawthorn genotypes were analyzed and also their individual organic acids, in order to better understand their use as functional foods, but also as ingredients in pharmaceutical, nutritional products and in medicine. HPLC analysis was carried out using a Surveyor Thermo Electron system. Ascorbic, oxalic, tartric, malic, citric, succinic and fumaric acids were detected. On average, malic acid was predominant with a range of 415.08 mg/100 g FW in Mespilus germanica and 1,128.68 mg/100 g FW in Crataegus pentagyna. The order of organic acid depending on their content/100 g FW was: for Mespilus germanica - malic > tartric > oxalic > citric > fumaric > ascorbic > succinic; for Crataegus monogyna - malic > oxalic > citric > succinic >tartric > ascorbic > fumaric; for Crataegus pentagyna - malic > citric > oxalic > succinic >tartric > ascorbic > fumaric. The data obtained in this study do confirm that medlar and hawthorn fruits are a rich source of organic acid, and their organic acid content within the 100 g was greater than human daily consumption for this required level.

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Kocks, Christian, Diana Wall, and Andreas Jupke. "Evaluation of a Prototype for Electrochemical pH-Shift Crystallization of Succinic Acid." Materials 15, no. 23 (November 25, 2022): 8412. http://dx.doi.org/10.3390/ma15238412.

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Downstream processing of biotechnologically produced carboxylic acids, such as succinic acid, poses environmental and economic challenges. Conventional downstream processes cause large amounts of waste salts, which have to be purified or disposed of. Therefore, lean and waste-free downstream processes are necessary for the biotechnological production of succinic acid. Electrochemical downstream processes gain especially significant attention due to low chemical consumption and waste reduction. This work presents the pH-dependent solid-liquid equilibrium of succinic acid, a prototype for electrochemical pH-shift crystallization processes, and its characterization. Based on the supersaturation, energy consumption, and electrochemical protonation efficiency the proposed electrochemical pH-shift crystallization is evaluated. This evaluation highlights the potential of the proposed electrochemical crystallization processes as waste-free and economically attractive processes for bio-based succinic acid production.

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Magee, J. B., and C. L. Gupton. "Comparative Organic Acid Profiles of Highbush, Southern Highbush, and Rabbiteye Blueberries." HortScience 33, no. 4 (July 1998): 592c—592. http://dx.doi.org/10.21273/hortsci.33.4.592c.

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The organic acid composition of blueberries of three highbush (Vaccinium corymbosum) cultivars, three rabbiteye (V. ashei cultivars and nine southern highbush (V. corymbosun hybrids) cultivars or selections was determined by HPLC. Species means off the individual acids (citric, malic, succinic, and quinic), expressed as a percentage of total acid, formed profiles or patterns that are thought to be characteristic of the species. Citric (75%) was the predominant acid in highbush fruit with lesser percentages of succinic (13%), quinic (9.6%), and malic (2.7%). The percent composition of rabbiteye berries [quinic (49%), succinic (39%), citric (6.7%), malic (5%)] was distinctly different from highbush. The acid profile of southern highbush fruit reflected their V. corymbosum heritage with an acid profile similar to that of highbush. When related to a clone's pedigree, these results suggest that organic acid profiles may be a useful screening tool for studying the contribution of southeastern native species such as V. darrowi or V. ashei to the inheritance of organic acids.

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Yoshikawa, Masami, Nobuhiro Hirai, Kohji Wakabayashi, Haruyuki Sugizaki, and Hajime Iwamura. "Succinic and lactic acids as plant growth promoting compounds produced by rhizospheric Pseudomonas putida." Canadian Journal of Microbiology 39, no. 12 (December 1, 1993): 1150–54. http://dx.doi.org/10.1139/m93-173.

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In greenhouse trials, root growth of Asparagus officinalis L. increased up to 30% when roots of 3-week-old seedlings were dipped in the culture filtrate of Pseudomonas putida RSA9, a strain isolated from rhizosphere soil of asparagus and antagonistic to the crown rot pathogen Fusarium moniliforme. The culture filtrate was extracted with ethyl acetate at pH 3, and the extracts were fractionated on a column of octadesylsilica gel. The active fraction was found to be a 45:55 mixture of succinic and lactic acids. Root mass increased 40% when the roots of the seedlings were treated with a 1:1 mixture of the acids at 10 ppm. The results provide an explanation for the plant growth promoting effects of some rhizobacteria; the bacteria may secrete organic acids, such as succinic and lactic acids, and these acids may increase plant growth under conditions in which the populations of pathogens are reduced.Key words: succinic acid, lactic acid, Pseudomonas putida, plant growth promotion, rhizobacteria, PGPR.

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Rössner, J., J. Velíšek, F. Pudil, and J. Davídek. "Strecker degradation products of aspartic and glutamic acids and their amides." Czech Journal of Food Sciences 19, No. 2 (February 7, 2013): 41–45. http://dx.doi.org/10.17221/6573-cjfs.

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Aspartic and glutamic acids, asparagine and glutamine were oxidised with either potassium peroxodisulphate or glyoxal. Nonvolatile products were derivatised and analysed by GC/FID and GC/MS. Volatile reaction products were isolated and analysed by the same methods. It was found that the degradation reactions of amino acids are complex. Amino acids are principally degraded via the corresponding a-keto acids to Strecker aldehydes (aspartic acid to oxalacetic and 3-oxopropionic acids and glutamic acid to a-ketoglutaric and 4-oxobutyric acids), which are unstable and decomposed by decarboxylation to the corresponding aldehydes. Aspartic acid also eliminates ammonia and yields fumaric acid whereas glutamic acid gives rise to an imine, pyroglutamic acid. A recombination of free radicals leads to dicarboxylic acids (succinic acid from aspartic acid, succinic, glutaric and adipic acids from glutamic acid). The major volatile products (besides the aldehydes) are lower carboxylic acids (acetic acid from aspartic acid and propionic acid acid from glutamic acid) that can at least partly arise by radical reactions. In both quality and quantity terms, a higher amount of degradation products arises by oxidation of amino acids by peroxodisulphate.

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Journal, Baghdad Science. "Separation and Determination of Some Organic Acids in Dry Calyces of Iraqi Hibiscus Sabdariffa Linn." Baghdad Science Journal 12, no. 2 (June 7, 2015): 340–49. http://dx.doi.org/10.21123/bsj.12.2.340-349.

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A new reversed phase- high performance liquid chromatographic (RP-HPLC) method with Ultraviolet-Visible spectrophotometry has been optimized and validated for the simultaneous extraction and determination of organic acids present in Iraqi calyces of Hibiscus Sabdraffia Linn. The method is based on using ultrasonic bath for extracting organic acids. Limit of detection in µg/ml of Formic acid, Acetic acid, Oxalic acid, Citric acid, Succinic acid, Tartaric acid, and Malic acid 126.8498×10-6, 113.6005×10-6, 97.0513×10-6, 49.7925×10-6, 84.0753×10-6, 92.6551×10-6, and 106.1633×10-6 ,respectively. The concentration of organic acids found in dry spacemen of calyces of Iraqi Hibiscus Sabdraffia Linn. under study: Formic acid, Acetic acid, Oxalic acid, Citric acid, Succinic acid, Tartaric acid, and Malic acid are 114.896 µg/g, 64.722 µg/g, 342.508 µg/g, 126.902 µg/g, 449.91 µg/g, 268.52 µg/g, and 254.07 µg/g respectively.

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SUZUKI, TAKESHI, FERGUS M. CLYDESDALE, and TIRA PANDOLF. "Solubility of Iron in Model Systems Containing Organic Acids and Lignin." Journal of Food Protection 55, no. 11 (November 1, 1992): 893–98. http://dx.doi.org/10.4315/0362-028x-55.11.893.

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The effect of six organic acids, ascorbic, citric, fumaric, lactic, malic, and succinic, alone and in combination, at a 1:1.9 molar ratio (Fe+2:ligand) on the solubility of iron was evaluated in the presence of lignin under simulated gastrointestinal pH conditions. The enhancing effect, evaluated under two systems of preparation at two pH values, was in the following order: citric>malic>ascorbic>lactic,fumaric>succinic. Citric acid solubilized 80 and 81% of iron under both pH conditions. When ascorbic acid was mixed with fumaric, lactic, and succinic acids, a higher percentage of soluble iron was retained than with these three acids alone. In the case of citric and malic acids, the addition of ascorbic acid reduced the soluble iron. The percentage of soluble iron obtained when prepared at the endogenous pH (2.5–3.1) was higher than that at pH 5.5. These results indicated that ascorbate bound less iron in a soluble form than citrate or malate but more than fumarate, lactate, or succinate. Also, combinations of citric with malic acid did not demonstrate a synergistic effect.

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27

Phurahong, Narunchara, and Nantana Jiratumnukul. "Preparation and Characterization of Surface-Modified Nanocellulose Fibers for Water-Based Coating Application." Key Engineering Materials 845 (May 2020): 21–26. http://dx.doi.org/10.4028/www.scientific.net/kem.845.21.

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Nanocellulose fibers (NCF) is a renewable biodegradable polymer in nature. It has extensively interest as a reinforcement material in nanocomposites due to its nanoscale advantages. However, the efficiency of NCF dispersion in polymer matrix has limitation due to its self-agglomeration.The objective of this research was to prepare surface-modified NCF using three different acids; succinic anhydride, phthalic anhydride and citric acid. The molar ratios of acid to anhydroglucose units in NCF used in this work were 6:1, 8:1 and 10:1. The effects of acid types and molar ratios toward physical properties were studied. The results showed that succinic anhydride-modified NCF provided the highest DS range from 0.46-0.86. Dispersion of succinic anhydride-modified NCF provided good stability in water for 30 days. The succinic anhydride-modified NCF of 1:6 molar ratio is suitable for emulsion coating application.

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28

Vida, Norbert, Jiří Václavík, and Petr Beier. "Synthesis and reactivity of aliphatic sulfur pentafluorides from substituted (pentafluorosulfanyl)benzenes." Beilstein Journal of Organic Chemistry 12 (January 20, 2016): 110–16. http://dx.doi.org/10.3762/bjoc.12.12.

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Oxidation of 3- and 4-pentafluorosulfanyl-substituted anisoles and phenols with hydrogen peroxide and sulfuric acid provided a mixture of SF5-substituted muconolactone, maleic, and succinic acids. A plausible mechanism for the formation of the aliphatic SF5 compounds was presented and their chemical reactivity was investigated. SF5-substituted para-benzoquinone was synthesized; its oxidation led to an improved yield of 2-(pentafluorosulfanyl)maleic acid. The reaction of SF5-substituted maleic anhydride and para-benzoquinone with cyclopentadiene afforded the Diels–Alder adducts. Decomposition of 3-(pentafluorosulfanyl)muconolactone in acidic, neutral and basic aqueous media was investigated and the decarboxylation of 2-(pentafluorosulfanyl)maleic acid provided 3-(pentafluorosulfanyl)acrylic acid.

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29

Song, Chae Eun, Han Hyo Shim, Palaniselvam Kuppusamy, Young-IL Jeong, and Kyung Dong Lee. "Potential Sustainable Properties of Microencapsulated Endophytic Lactic Acid Bacteria (KCC-42) in In-Vitro Simulated Gastrointestinal Juices and Their Fermentation Quality of Radish Kimchi." BioMed Research International 2018 (September 3, 2018): 1–10. http://dx.doi.org/10.1155/2018/6015243.

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The objective of this study was to investigate alginate microencapsulated lactic acid bacteria (LAB) fermentation quality of radish kimchi sample and its potential survivability in different acidic and alkaline environments. Initially, we isolated 45 LAB strains. One of them showed fast growth pattern with potential probiotic and antifungal activities against Aspergillus flavus with a zone of inhibition calculated with 10, 8, 4mm for the 4th, 5th, and 6th day, respectively. Therefore, this strain (KCC-42) was chosen for microencapsulation with alginate biopolymer. It showed potential survivability in in-vitro simulated gastrointestinal fluid and radish kimchi fermentation medium. The survival rate of this free and encapsulated LAB KCC-42 was 6.85 × 105 and 7.48× 105 CFU/ml, respectively; the viability count was significantly higher than nonencapsulated LAB in simulated gastrointestinal juices (acid, bile, and pancreatin) and under radish kimchi fermentation environment. Kimchi sample added with this encapsulated LAB showed increased production of organic acids compared to nonencapsulated LAB sample. Also, the organic acids such as lactic acid, acetic acid, propionic acid, and succinic acid production in fermented kimchi were measured 59mM, 26mM, 14mM, and 0.6mM of g/DW, respectively. The production of metabolites such as lactic acid, acetic acid, and succinic acid and the bacteria population was high in microencapsulated LAB samples compared with free bacteria added kimchi sample. Results of this study indicate that microencapsulated LAB KCC-42 might be a useful strategy to develop products for food and healthcare industries.

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30

Domingo, J. L., M. Gómez, J. M. Llobet, and J. Corbella. "Comparative Effects of Several Chelating Agents on the Toxicity, Distribution and Excretion of Aluminium." Human Toxicology 7, no. 3 (May 1988): 259–62. http://dx.doi.org/10.1177/096032718800700305.

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The relative efficacy of citric, malic, malonic, oxalic and succinic acids, and deferoxamine mesylate (DFOA) on the toxicity, distribution and excretion in mice exposed to aluminium were compared. Chelating agents were administered intraperitoneally at a dose equal to one-fourth of their respective LD50. To determine the effect of the various chelators on the toxicity of aluminium, various doses of aluminium nitrate (938-3188 mg/kg) were administered intraperitoneally, followed by one of the chelators. Survival was recorded at the end of 14 days. Malic and succinic acids were the most effective. Malic acid and DFOA were the most effective in increasing the urinary excretion of aluminium. Citric acid was the most effective in increasing the faecal excretion of aluminium. Malonic, oxalic and succinic acids had no overall beneficial effects. Citric acid would appear to be the most effective agent of those tested in the prevention of acute aluminium intoxication. However, before the use of these compounds in human aluminium intoxication is possible, further investigations including the effects of these chelators after chronic aluminium intoxication are required.

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31

Kvaratskhelia, E., and R. Kurtanidze. "PECULIARITIES OF ELECTROLYTIC DISSOCIATION OF ETHYL DERIVATIVES OF SUCCINIC ACID." Chemical Problems 2018, no. 1 (2018): 63–68. http://dx.doi.org/10.32737/2221-8688-2018-1-63-68.

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32

Ergönül, P. G., and C. Nergiz. "Determination of organic acids in olive fruit by HPLC." Czech Journal of Food Sciences 28, No. 3 (July 1, 2010): 202–5. http://dx.doi.org/10.17221/1379-cjfs.

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Organic acids (oxalic, citric, malic, and succinic) contents of Domat, Memecik and Uslu varieties of olives grown in Turkey were investigated using HPLC method. Organic acids were extracted from olives with water-methanol mixture solution 75:25 (v/v) and were analysed through KC-118 ion-exchange column using UV absorbance detector at 214 nm. The mobile phase was phosphoric acid (0.1%, w/v). The recovery values of the organic acids added into olive fruit samples were 92.8%, 98.75%, 110%, and 86% for oxalic, citric, malic, and succinic acids, respectively.

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33

Rahman, Fatinah Ab, Syarifah Abd Rahim, C. Tan Chou, Souk H. Low, and Noor Ashila Ramle. "Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method." International Journal of Chemical Engineering and Applications 8, no. 2 (April 2017): 136–40. http://dx.doi.org/10.18178/ijcea.2017.8.2.645.

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34

Fuleki, Tibor, Estela Pelayo, and Rodrigo B. Palabay. "Carboxylic Acid Composition of Authentic Varietal and Commercial Grape Juices." Journal of AOAC INTERNATIONAL 76, no. 3 (May 1, 1993): 591–600. http://dx.doi.org/10.1093/jaoac/76.3.591.

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Abstract Quantities were determined of tartaric, malic, citric, lactic, succinic, and shikimic acid present in juices produced by cold and hot pressing from 56 grape cultivars grown in Ontario for the 1988 and 1989 seasons. The individual acids were separated by liquid chromatography (LC) and detected at 210 or 250 nm. Lactic and succinic acids were determined enzymatically. The ranges of acid concentrations found were as follows: tartaric, 4.19-13.51 g/L; malic, 1.68-15.36 g/L; citric, 0.305-1.158 g/L; lactic, 0.015-0.388 g/L; succinic, 0.002-0.075 g/L; and shikimic, 0-0.102 g/L. Tartaric and malic acids were the major acids in every cultivar. The tartaric:malic acid ratio ranged from 0.52 to 4.36, but it was >1.0 in most cases. Genotype had significant effect only on the shikimic acid content. Hot pressing of red cultivars yielded juice with significantly higher pH and tartaric, citric, lactic, and total acid contents than cold pressing. Vintage had no significant effect on acid composition. The total acid content determined by LC was always considerably higher than the titratable acidity, but good correlation existed between the 2 measurements. Most commercial grape juice had similar composition to that of authentic juices. However, tartaric acid content was lower in the majority of commercial juices because of losses during the detartration process. Also, indications of acidulation existed in some of the commercial juices.

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35

Sato, Kei, Fumikazu Ikemori, Sathiyamurthi Ramasamy, Akihiro Fushimi, Kimiyo Kumagai, Akihiro Iijima, and Yu Morino. "Four- and Five-Carbon Dicarboxylic Acids Present in Secondary Organic Aerosol Produced from Anthropogenic and Biogenic Volatile Organic Compounds." Atmosphere 12, no. 12 (December 20, 2021): 1703. http://dx.doi.org/10.3390/atmos12121703.

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To better understand precursors of dicarboxylic acids in ambient secondary organic aerosol (SOA), we studied C4–C9 dicarboxylic acids present in SOA formed from the oxidation of toluene, naphthalene, α-pinene, and isoprene. C4–C9 dicarboxylic acids present in SOA were analyzed by offline derivatization gas chromatography–mass spectrometry. We revealed that C4 dicarboxylic acids including succinic acid, maleic acid, fumaric acid, malic acid, DL-tartaric acid, and meso-tartaric acid are produced by the photooxidation of toluene. Since meso-tartaric acid barely occurs in nature, it is a potential aerosol tracer of photochemical reaction products. In SOA particles from toluene, we also detected a compound and its isomer with similar mass spectra to methyltartaric acid standard; the compound and the isomer are tentatively identified as 2,3-dihydroxypentanedioic acid isomers. The ratio of detected C4–C5 dicarboxylic acids to total toluene SOA mass had no significant dependence on the initial VOC/NOx condition. Trace levels of maleic acid and fumaric acid were detected during the photooxidation of naphthalene. Malic acid was produced from the oxidation of α-pinene and isoprene. A trace amount of succinic acid was detected in the SOA produced from the oxidation of isoprene.

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36

HINTON, ARTHUR. "Growth of Campylobacter in Media Supplemented with Organic Acids†." Journal of Food Protection 69, no. 1 (January 1, 2006): 34–38. http://dx.doi.org/10.4315/0362-028x-69.1.34.

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The growth of Campylobacter spp. in media supplemented with organic acids was examined. A Bioscreen C Microbiology Reader was used to measure growth of cultures incubated at 37°C for 48 h in a tryptose–yeast extract basal broth medium and in basal broth supplemented with 10, 20, 30, 40, or 50 mM citric, fumaric, lactic, malic, or succinic acid. Growth of three of six isolates was significantly greater (P ≤ 0.05) in media supplemented with 20 to 50 mM citric acid than in nonsupplemented media, growth of five of six isolates was significantly greater in media supplemented with 10 to 50 mM succinic acid than in nonsupplemented media, and growth of six of six isolates was significantly greater in media supplemented with 10 to 50 mM fumaric or malic acid or with 20 to 50 mM lactic acid than in nonsupplemented media. Isolates were also cultured in basal media supplemented with a mixture of 10, 20, 30, 40, or 50 mM fumaric, malic, lactic, and succinic acids. Results indicated that the growth of all Campylobacter isolates was significantly greater in media supplemented with mixtures containing each of these organic acids at 10 to 40 mM than in nonsupplemented media. These findings indicate that in vitro growth of Campylobacter spp. may be significantly enhanced in media supplemented with organic acids that support the growth of these bacteria.

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37

Huang, Yan, Dandan Pu, Zhilin Hao, Li Liang, Jing Zhao, Yizhuang Tang, and Yuyu Zhang. "Characterization of Taste Compounds and Sensory Evaluation of Soup Cooked with Sheep Tail Fat and Prickly Ash." Foods 11, no. 7 (March 22, 2022): 896. http://dx.doi.org/10.3390/foods11070896.

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Sheep tail fat and prickly ash play an important role in improving the umami taste of mutton soup. In this work, the effects of prickly ash on key taste compounds in stewed sheep tail fat soup were investigated. Results showed that the taste intensity of sheep tail fat soup cooked with 0.2% prickly ash increased significantly. The concentration of organic acids and free amino acids in sheep tail fat soup significantly increased with the addition of prickly ash. The concentration of succinic acid (2.637 to 4.580 mg/g) and Thr (2.558 to 12.466 mg/g) increased the most among organic acids and amino acids, respectively. Spearman’s correlation analysis elucidated that seven taste compounds were positively correlated (correlation coefficient > 0.7) with the overall taste intensity of the soup sample including Thr, Asp, oxalic acid, lactic acid, citric acid, succinic acid, and ascorbic acid. Additional experiments and quantitative descriptive analysis further confirmed that Asp, lactic acid and citric acid were the key taste compounds to improve saltiness and umami taste in sheep tail fat soup with prickly ash.

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38

Cascaval, Dan, Radu Tudose, and Comeliu Oniscu. "REACTIVE EXTRACTION OF DICARBOXYLIC ACIDS I. MECHANISM, LIMITING STEPS AND KINETICS." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 5, no. 5 (December 20, 1997): 97–110. http://dx.doi.org/10.48141/sbjchem.v5.n5.1997.95_1997.pdf.

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In this paper the reactive extraction of some dicarboxylic acids (oxalic acid, malonic acid, succinic acid, glutaric acid, and adipic acid) have been studied. These acids have been extracted by Amberlite LA-2 in butyl acetate using a modified extraction cell of the Lewis type. Mechanism, limiting steps, and kinetic of the mass transfer process have been settled.

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39

Beloborodova, Pautova, Sergeev, and Fedotcheva. "Serum Levels of Mitochondrial and Microbial Metabolites Reflect Mitochondrial Dysfunction in Different Stages of Sepsis." Metabolites 9, no. 10 (September 20, 2019): 196. http://dx.doi.org/10.3390/metabo9100196.

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Mechanisms of mitochondrial dysfunction in sepsis are being extensively studied in recent years. During our study, concentrations of microbial phenolic acids and mitochondrial metabolites (succinic, α-ketoglutaric, fumaric, itaconic acids) as indicators of sepsis and mitochondrial dysfunction, respectively, are measured by gas chromatography–mass spectrometry (GC–MS) in the blood of critically ill patients at the early and late stages of documented sepsis. The increase in levels of some phenylcarboxylic (phenyllactic (PhLA), p-hydroxyphenylacetic (p-HPhAA), p-hydroxyphenyllactic (p-HPhAA)) acids (PhCAs), simultaneously with a rise in levels of mitochondrial dicarboxylic acids, are mainly detected during the late stage of sepsis, especially succinic acid (up to 100–1000 µM). Itaconic acid is found in low concentrations (0.5–2.3 µM) only at early-stage sepsis. PhCAs in vitro inhibits succinate dehydrogenase (SDH) in isolated mitochondria but, unlike itaconic acid which acts as a competitive inhibitor of SDH, microbial metabolites most likely act on the ubiquinone binding site of the respiratory chain. A close correlation of the level of succinic acid in serum and sepsis-induced organ dysfunction is revealed, moreover the most significant correlation is observed at high concentrations of phenolic microbial metabolites (PhCAs) in late-stage sepsis. These data indicate the promise of such an approach for early detection, monitoring the progression of organ dysfunction and predicting the risk of non-survival in sepsis.

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40

Tsuda, Taizo, Hiroshi Nakanishi, Takashi Morita, and Junko Takebayashi. "Simultaneous Gas Chromatographic Determination of Carboxylic Acids in Soft Drinks and Jams." Journal of AOAC INTERNATIONAL 68, no. 5 (September 1, 1985): 902–5. http://dx.doi.org/10.1093/jaoac/68.5.902.

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Abstract A method was developed for simultaneous gas chromatographic determination of sorbic acid, dehydroacetic acid, and benzoic acid used as preservatives, and succinic acid, fumaric acid, malic acid, and tartaric acid used as acidulants in soft drinks and jams. A sample was dissolved in NH4OH-NH4CI pH 9 buffer solution, and an aliquot of the solution was passed through a QAE-Sephadex A 25 column. The column was washed with water, and the carboxylic acids were eluted with 0.1N HC1. Sorbic acid, dehydroacetic acid, and benzoic acid were extracted with ethyl ether-petroleum ether (1 + 1), and determined on a 5% DEGS + 1% H3PO4 column. Succinic acid, fumaric acid, malic acid, and tartaric acid in the lower layer were derivatized with N,0- bis(trimethylsilyl)acetamide and trimethylchlorosilane, and determined on a 3% SE-30 column. Recoveries from soft drink and jam samples fortified with 0.1% each of 7 carboxylic acids ranged from 92.4 to 102.6% for preservatives, and from 88.1 to 103.2% for acidulants.

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41

Schäfer, H., K. Taraz, and H. Budzikiewicz. "Zur Genese Der Amidisch An Den Chromophor Von Pyoverdinen Gebundenen Dicarbonsäuren [1]." Zeitschrift für Naturforschung C 46, no. 5-6 (June 1, 1991): 398–406. http://dx.doi.org/10.1515/znc-1991-5-611.

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Pseudomonas strains of the so-called fluorescent group usually produce several pyoverdins which differ only in the nature of a dicarboxylic acid bound amidically to the chromophor. For the pyoverdins isolated from the culture medium of Pseudomonas fluorescens 12 it is shown that succinic acid is an artefact formed by hydrolysis of succinic amide, and that a-ketoglutaric acid is transformed enzymatically to glutamic acid. This process is reversed after the phase of exponential growth of the bacteria. The ratio C4- vs. C5 -acids changes with the culture time and with increasing Fe3+ content of the medium in favor of the latter

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42

N, Hema, and K. P. Sreenath. "Molecular Identification of Bacterial Strains Producing Succinic Acid from Indian Sources." Journal of Pure and Applied Microbiology 12, no. 4 (December 30, 2018): 2313–19. http://dx.doi.org/10.22207/jpam.12.4.73.

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43

Poz, I. L., and A. G. Strokov. "Acid ion modification in a dialysis fluid." Russian Journal of Transplantology and Artificial Organs 21, no. 4 (February 2, 2020): 129–33. http://dx.doi.org/10.15825/1995-1191-2019-4-129-133.

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Apart from its main electrolytes – sodium, potassium, calcium and magnesium – a dialysis fluid (DF) contains a buffer for correction of acidosis. A small amount of acid is added to the DF to prevent calcium and magnesium precipitation. Acetic acid has traditionally been used for this purpose. Several studies have shown that acetate ion, even in small concentrations, can cause a number of adverse events, such as low blood pressure, production of proinflammatory cytokines, etc. This literature review aims at considering alternative acidic components of DF, such as citric, hydrochloric, and succinic acids, as well as their advantages, possibilities and features of their use in wide clinical practice.

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44

Roy, Siddhartha, Desh Deepak Singh, and M. Vijayan. "X-ray studies on crystalline complexes involving amino acids and peptides. XLII. Adipic acid complexes of L- and DL-arginine and supramolecular association in arginine–dicarboxylic acid complexes." Acta Crystallographica Section B Structural Science 61, no. 1 (January 19, 2005): 89–95. http://dx.doi.org/10.1107/s0108768104030010.

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The adipic acid complexes of DL-arginine and L-arginine are made up of zwitterionic, singularly positively charged arginium ions and doubly negatively charged adipate ions, with a 2:1 stoichiometry. One of the two crystallographically independent arginium ions in the L-arginine complex has a conformation hitherto unobserved in crystal structures containing the amino acid. In the present study the structural data on arginine complexes of saturated dicarboxylic acids with 0–5 C atoms separating the two carboxyl functions are given. In terms of molecular aggregation, formic and acetic acid complexes behave in a similar way to those involving fairly long carboxylic acids such as adipic acid. By and large, the supramolecular assembly in complexes involving dicarboxylic acids with 3 or more C atoms separating the carboxyl groups (glutaric, adipic and pimelic acids), and those involving formic and acetic acids, have common features. The aggregation patterns in complexes involving oxalic, malonic and maleic acids do not share striking features among themselves (except for the mode of hydrogen-bonded dimerization of arginium ions) or with those involving larger dicarboxylic acids. Complexes of succinic acid, the shortest linear dicarboxylic acid, share features with those involving shorter as well as longer dicarboxylic acids. The difference in the behaviour of long and short dicarboxylic acids and the ambiguous behaviour of succinic acid can be broadly related to their lengths.

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45

Savych, Alona, Svitlana Marchyshyn, Roksolana Basaraba, and Liubomyr Kryskiw. "Determination of carboxylic acids content in the herbal mixtures by HPLC." ScienceRise: Pharmaceutical Science, no. 2 (30) (April 30, 2021): 33–39. http://dx.doi.org/10.15587/2519-4852.2021.229132.

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The aim of the study was to research the qualitative composition and to investigate the quantitative content of some carboxylic acids in the herbal mixtures with established hypoglycemic, hypolipidemic and antioxidant activity in previous studies in vivo. Materials and methods. Studies of carboxylic acid content in the herbal mixtures were performed by HPLC analysis using Agilent Technologies 1200 liquid chromatograph (USA). Identification and quantitative analysis were performed using standard solutions of carboxylic compounds (tartaric, pyruvic, isocitric, citric, succinic and fumaric acids). Conclusions. HPLC analysis of five samples of the herbal mixture with antidiabetic activity showed the presence of six carboxylic acids. The dominant acid in all samples was isocitric acid. Among the most important for the prevention and treatment of diabetes, high levels of succinic and fumaric acids have been identified and established. The obtained data indicate a correlation between the phytochemical composition of the studied herbal mixtures and their pharmacodynamics, which was previously established

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46

Chen, Raymond, Sonja Sekulic, and Todd Zelesky. "Development and Validation of a Cost-Effective, Efficient, and Robust Liquid Chromatographic Method for the Simultaneous Determination of the Acetyl and Succinoyl Content in Hydroxypropyl Methylcellulose Acetate Succinate Polymer." Journal of AOAC INTERNATIONAL 85, no. 4 (July 1, 2002): 824–31. http://dx.doi.org/10.1093/jaoac/85.4.824.

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Abstract A reversed-phase liquid chromatographic method was developed and validated for the determination of the content of free acetic acid, free succinic acid, acetyl substituents, and succinoyl substituents in hydroxypropyl methylcellulose acetate succinate (HPMCAS; Chemical Abstracts Service Registry No. 71138-97-1) polymer. This single new method gave accurate and precise measurement of both acetyl and succinoyl substituents, which had previously required 3 Japanese Pharmaceutical Excipients (JPE) methods to accomplish. Consequently, analysis time and turnaround time are decreased significantly. Furthermore, this method can also separate and determine the free acetic and succinic acids in HPMCAS polymer, a task that the corresponding JPE method cannot achieve. The values for accuracy (average recovery from 12 standard samples) were 99.9% for acetic acid and 99.8% for succinic acid. The values for injection precision (relative standard deviation [RSD]) were 0.11% for acetic acid and 0.28% for succinic acid. The values for intermediate precision (RSD) were 1.25% for determination of the acetyl content at the 8.78% (w/w) level and 1.33% for determination of the succinoyl content at the 10.9% (w/w) level. The values for intermediate precision (RSD) were 5.98% for determination of free acetic acid at the 0.12% (w/w) level and 5.13% for determination of free succinic acid at the 0.029% (w/w) level. The method was proven to be robust with respect to variation in the pH of the mobile phase, the concentration of potassium dihydrogen phosphate, and the flow rate. The method is well suited for quality control in today's fast-paced pharmaceutical laboratories.

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Sá-Pessoa, Joana, Sandra Paiva, David Ribas, Inês Jesus Silva, Sandra Cristina Viegas, Cecília Maria Arraiano, and Margarida Casal. "SATP (YaaH), a succinate–acetate transporter protein in Escherichia coli." Biochemical Journal 454, no. 3 (August 29, 2013): 585–95. http://dx.doi.org/10.1042/bj20130412.

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In the present paper we describe a new carboxylic acid transporter in Escherichia coli encoded by the gene yaaH. In contrast to what had been described for other YaaH family members, the E. coli transporter is highly specific for acetic acid (a monocarboxylate) and for succinic acid (a dicarboxylate), with affinity constants at pH 6.0 of 1.24±0.13 mM for acetic acid and 1.18±0.10 mM for succinic acid. In glucose-grown cells the ΔyaaH mutant is compromised for the uptake of both labelled acetic and succinic acids. YaaH, together with ActP, described previously as an acetate transporter, affect the use of acetic acid as sole carbon and energy source. Both genes have to be deleted simultaneously to abolish acetate transport. The uptake of acetate and succinate was restored when yaaH was expressed in trans in ΔyaaH ΔactP cells. We also demonstrate the critical role of YaaH amino acid residues Leu131 and Ala164 on the enhanced ability to transport lactate. Owing to its functional role in acetate and succinate uptake we propose its assignment as SatP: the Succinate–Acetate Transporter Protein.

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Leszczewicz, Martyna, and Piotr Walczak. "Selection of Thermotolerant Corynebacterium glutamicum Strains for Organic Acid Biosynthesis." Food technology and biotechnology 57, no. 2 (2019): 249–59. http://dx.doi.org/10.17113/ftb.57.02.19.5980.

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In recent years, Corynebacterium glutamicum has been considered as producer of many valuable chemical compounds. Among them, organic acids such as L-lactic and succinic acids are the most important ones. It is known that the wild-type C. glutamicum grows well in the temperature range between 25 and 37 °C. Above 40 °C, the biomass growth usually abruptly stops; however, the bacteria remain metabolically active. High temperature affects the metabolic activity of C. glutamicum cells and can lead to changes in the composition and quantity of the fermentation products. Therefore, in a series of subsequent selection steps, we tried to obtain prototrophic strains capable of growing at 44 °C from the culture of homoserine auxotroph C. glutamicum ATCC 13287. During selection, we used complex and mineral media containing succinic and citric acids. As a result, we obtained 47 clones able to grow at elevated temperature. Moreover, the estimated optimal growth temperature for several of them was about 40 °C or higher. Under oxygen limitation conditions, C. glutamicum strains produce organic acids. Regardless of the tested clone, L-lactic acid was the main product. However, its concentration was the highest in the cultures performed at 44 °C. The elevated temperature also affected the biosynthesis of other organic acids. Compared to the parental strain, the concentration of acetic acid increased, and of succinic acid decreased in the cultures of thermotolerant strains. Strain RCG44.3 exhibited interesting properties; it was able to synthesise 27.1 g/L L-lactic acid, with production yield of 0.57 g/g, during 24 h of fermentation at 44 °C.

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Lin, Yun, Yuemeng Ji, Yixin Li, Jeremiah Secrest, Wen Xu, Fei Xu, Yuan Wang, Taicheng An, and Renyi Zhang. "Interaction between succinic acid and sulfuric acid–base clusters." Atmospheric Chemistry and Physics 19, no. 12 (June 18, 2019): 8003–19. http://dx.doi.org/10.5194/acp-19-8003-2019.

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Abstract. Dicarboxylic acids likely participate in the formation of pre-nucleation clusters to facilitate new particle formation in the atmosphere, but the detailed mechanism leading to the formation of multicomponent critical nuclei involving organic acids, sulfuric acid (SA), base species, and water remains unclear. In this study, theoretical calculations are performed to elucidate the interactions between succinic acid (SUA) and clusters consisting of SA-ammonia (AM)∕dimethylamine (DMA) in the presence of hydration of up to six water molecules. Formation of the hydrated SUA⚫SA⚫ base clusters is energetically favorable, triggering proton transfer from SA to the base molecule to form new covalent bonds or strengthening the preexisting covalent bonds. The presence of SUA promotes hydration of the SA⚫AM and SA⚫AM⚫DMA clusters but dehydration of the SA⚫DMA clusters. At equilibrium, SUA competes with the second SA molecule for addition to the SA⚫ base clusters at atmospherically relevant concentrations. The clusters containing both the base and organic acid are capable of further binding with acid molecules to promote subsequent growth. Our results indicate that the multicomponent nucleation involving organic acids, sulfuric acid, and base species promotes new particle formation in the atmosphere, particularly under polluted conditions with a high concentration of diverse organic acids.

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Voronkov, Andrey V., Dmitry I. Pozdnyakov, Similla L. Adjiahmetova, Nadezhda M. Chervonnaya, Victoria M. Rukovitsina, and Eduard "T" Oganesyan. "Influence of some cinnamic acid derivatives on changes of the tricarboxylic acid cycle enzymes activity in rats under brain ischemia conditions." Medical academic journal 20, no. 2 (September 2, 2020): 27–32. http://dx.doi.org/10.17816/maj33994.

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The aim of the study was to assess the effect of certain derivatives of cinnamic acids on changes of the tricarboxylic acid cycle enzymes activity under experimental cerebral ischemia. Materials and methods. Brain ischemia was modeled by irreversible right-sided coagulation of the middle cerebral artery. Test compounds: 4-hydroxy-3,5-ditretbutyl cinnamic acid, coumaric, coffee, synapic, cinnamic, 4-hydroxycinnamic and ferulic acids, as well as a reference drug succinic acid was administered at a dose of 100 mg / kg per os for 3 days after the reproduction of ischemia. Then, changes in the activity of aconitase, citrate synthase, and -ketoglutarate dehydrogenase were evaluated in the supernatant of the brain. Results. The use of all the studied compounds and the reference drug helped to restore the activity of enzymes of the tricarboxylic acid cycle. The most pronounced results were obtained when animals were treated by 4-hydroxy-3,5-ditretbutyl cinnamic acid, against the background of which the activity of citrate synthase was higher than in animals treated by succinic, coumaric, coffee, synapic and ferulic acids by 1.53 (p 0.05), 1.41 (p 0.05), 1.4 (p 0.05), 1.46 (p 0.05) and 1.41 (p 0.05) times, respectively. Also, with the administration of 4-hydroxy-3,5-ditretbutyl cinnamic acid, the activity of aconitase was higher compared to rats that were administered with succinic, coumaric, coffee, synapic and ferulic acids by 2.47 (p 0.05), 2.49 (p 0.05), 3.44 (p 0.05), 2.59 (p 0.05) and 1.9 (p 0.05) times, respectively. Conclusion. The administration of the studied in this work cinnamic acid derivatives helps to restore the activity of citrate synthase, aconitase, and -ketoglutarate dehydrogenase in rats under conditions of cerebral ischemia. The most pronounced changes in the activity of enzymes were obtained with the iadministration of 4-hydroxy-3,5-ditretbutyl cinnamic acid.

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Journal articles on the topic 'Acidi succinici'

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