Academic literature on the topic 'Acides et sels biliaires – analyse'
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Journal articles on the topic "Acides et sels biliaires – analyse":
Yolou, S., J. L. Delarbre, and L. Maury. "Analyse Vibrationnelle des Acides gem-Dimethylglutarique en Solution Aqueuse. I-Acide 2,2-Dimethylglutarique et Ses Sels de Potassium." Journal of Raman Spectroscopy 23, no. 9 (September 1992): 501–8. http://dx.doi.org/10.1002/jrs.1250230907.
Yolou, S., J. L. Delarbre, E. Bourret, J. Roger, and L. Maury. "Analyse Vibrationnelle des Acides gem-Dimethylglutarique en Solution Aqueuse II-Acide 3,3-Dimethylglutarique et Ses Sels de Potassium." Journal of Raman Spectroscopy 24, no. 4 (April 1993): 183–90. http://dx.doi.org/10.1002/jrs.1250240402.
Dissertations / Theses on the topic "Acides et sels biliaires – analyse":
Descat, Amandine. "Développements de méthodes d'analyse des plastifiants de type phtalates et des acides biliaires dans des matrices biologiques : applications dans différents contextes physiopathologiques." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS054.
This thesis has two main focuses:1/ Plasticizers, including phthalates, have been identified as category 1b carcinogenic, mutagenic and reprotoxic (CMR) and as endocrine disruptors. Di-2-ethylhexyl phthalate (DEHP) is one of the most common plasticizers and is generally associated with polyvinyl chloride (PVC) in medical devices. As DEHP is not covalently bound to PVC, it can easily migrate into lipophilic matrices and then reach the bloodstream. It is metabolized by the liver into mono-2-ethylhexyl phthalate (MEHP), which is just as toxic. In recent years, alternative plasticizers to DEHP have been developed, notably di-2-ethylhexyl terephthalate (DEHT), which is metabolized in vivo to mono-2-ethylhexyl terephthalate (MEHT).The first part of this thesis involved developing methods for measuring plasticizers and their metabolites in various biological matrices, such as plasma. Two LC-MS/MS methods were developed for the determination of DEHP and MEHP as well as DEHT metabolites. As the ionization in mass spectrometry of DEHT is very low, a LC-UV method was developed to quantify this terephthalate. These methods have made it possible to estimate the release of DEHP and DEHT from blood bags and to measure their primary metabolites in blood products.2/ Bile acids (BA) are a large family of steroids made up of numerous species. They are synthesized in the liver and intestine and represent the main route of cholesterol catabolism. 7a-hydroxy-4-cholesten-3-one (C4) is the precursor of BA. BA play an essential role in lipid absorption but also in cell signaling, as they are ligands for the nuclear receptor 'Farnesoid X receptor' (FXR) and/or the G protein-coupled membrane receptor, TGR5. These receptors, and hence their ligands, are involved in glucose homeostasis, lipid homeostasis and energy expenditure. Any modulation of the BA profile can therefore lead to changes in metabolic homeostasis. The second part of this thesis involved developing two LC-MS/MS assay methods for 31 BA species and C4 in different biological matrices, including plasma. A specific method for the determination of recently described BA derived from LCA in caecal contents is currently being optimized. These methods have made it possible to analyze variations in the BA profile in various cardiometabolic disease contexts (obesity, insulin resistance, type 2 diabetes, NAFLD).In conclusion, the analytical methods developed for quantifying plasticizers and BA have been validated and applied in preclinical and clinical studies. Interestingly, data from the literature and preliminary transient transfection assays have shown that phthalates and their metabolites modulate the activity of the peroxisome proliferator-activated receptor alpha (PPARa), a key regulator of metabolic homeostasis and expression of CYP7A1 (a major enzyme in hepatic BA synthesis). The analytical tools developed in this thesis open up original perspectives for studying the effects of phthalates on metabolic homeostasis via the regulation of BA metabolism. All of this work has made it possible to link analytical developments and applications in the field of biology and health
Pean, Noémie. "Récepteur TGR5 des acides biliaires : impact sur la régénération du foie et l'homéostasie biliaire." Paris 7, 2014. http://www.theses.fr/2014PA077055.
BA composition (plasma, liver, bile, urine, stools) was more hydrophobic in TGR5-KO than in W1 mice. After PH, severe hepatocyte necrosis, prolonged cholestasis, exacerbated inflammatory response and delayed regeneration were observed in TGR5-KO mice. Hepatocyte adaptive response to post-PH BA overload was similar in WT and TGR5-KO mice. However, kidney and biliary adaptive responses to post-PH BA overload were strongly impaired in TGR5-KO as compared with WT mice. Cholestyramine treatment, as well as Kupffer cell depletion, significantly improved the post-PH TGR5 KO mice phenotype. After bile duct ligation or upon a cholic acid-enriched diet, TGR5 KO mice exhibited more severe liver injury than WT as well as impaired BA elimination in urine. In TGR5-KO mice, hepatic bile acid synthesis and cholecystohepatic shunt were not altered, but gallbladder relaxation and biliary epithelium hyperpermeability were observed as compared to WT mice. TGR5 is crucial for liver protection against BA overload after PH, primarily through the control of bile hydrophobicity and cytokine secretion. In the absence of TGR5, intrahepatic stasis of abnormally hydrophobic bile and excessive inflammation, in association with impaired bile flow adaptation and deficient urinary BA efflux, lead to BA overload-induced liver injury and delayed regeneration. TGR5 may control both bile acid pool hydrophobicity via the control of gallbladder motor function, and epithelial permeability in the biliary tract
Xupei, Huang. "Contribution à l'étude de l'activation de la protéine kinase C par deux familles de promoteurs de tumeurs : les sels biliaires et les acides gras insaturés." Paris 12, 1992. http://www.theses.fr/1992PA120015.
Claudel, Thierry. "Rôle du récepteur nucléaire FXR dans le métabolisme lipidique." Lille 2, 2003. http://www.theses.fr/2003LIL2P005.
Pasqualini, Eric. "La lipase sels biliaires-dépendante du pancréas : rôle de la phosphorylation et caractérisation d'une isoforme oncofoetale." Aix-Marseille 3, 1998. http://www.theses.fr/1998AIX30059.
Yolou, Séri. "Analyse vibrationnelle et structurale de diacides aliphatiques oxo et gem-dimethyle substitués et de leurs sels alcalins en solution aqueuse." Montpellier 1, 1992. http://www.theses.fr/1992MON13520.
Olivier, Jean-François. "Influence du pH dans la capacité d'adsorption des sels biliaires et des lysolécithines "in vitro" par les antiacides contenant de l'argile et/ou de l'aluminium." Paris 5, 1995. http://www.theses.fr/1995PA05P110.
Ramière, Christophe. "Interactions entre le métabolisme hépatique des sels biliaires et des lipoprotéines et les infections par les virus des hépatites B et C." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10016.
Hepatitis B and C viruses (HBV and HCV) infections are tightly linked with hepatic lipid metabolism. HBV replication depends on specific nuclear receptors, such as HNF4α and PPARα, both implicated in this metabolism. HCV assembly depends on the synthesis of Very-Low-Density Lipoproteins (VLDL), and the virus circulates in the blood as lipo-viral-particles associated in particular with apoB, an essential component of VLDL. In this study, we first studied the influence of FXRα, the nuclear receptor for bile acids, on HBV replication. We showed that, in vitro, bile acids, via FXRα, were able to activate the HBV Core promoter which controls the level of viral replication. Then, in the study of the interactions between HCV and lipoproteins, we demonstrated that apoB, which is associated with a proportion of viral particles, played an important role in HCV infectivity in vitro, and that Cideb, a protein involved in VLDL assembly, was implicated in the association between HCV and apoB and influenced the infectivity of secreted viral particles. Finally, we showed that, besides HCV infectious particles, sub-particles bearing only viral envelope glycoproteins circulated in the blood of infected patients. Interactions of HBV with the metabolism of bile acids, and of HCV with the metabolism of lipoproteins, are two examples of adaptation of a parasite to its host. The potential benefits from these interactions are still to be determined, as well as the possibility to develop anti-viral strategies targeting lipid metabolism
Ramsis, Hassan. "Analyse vibrationnelle et structurale de biomolécules en solution aqueuse : acides adipique, diglycolique, thiodiglycolique et leur sels alcalins." Montpellier 1, 1996. http://www.theses.fr/1996MON13508.
Favé, Gaëlle. "Stratégies d'amélioration de la biodisponibilité des acides gras : approches physico-chimiques et enzymatiques." Aix-Marseille 2, 2006. https://tel.archives-ouvertes.fr/tel-00689483.
Books on the topic "Acides et sels biliaires – analyse":
Riadh, Jazrawi, Northfield Tim, and Zentler-Munro Patrick, eds. Bile acids in health and disease: Update on cholesterol gallstones and bile acid diarrhoea. Dordrecht: Kluwer Academic, 1988.
Northfield, T. C., P. Zentler-Munro, and R. Jazwari. Bile Acids in Health and Disease: Update on Cholesterol Gallstones and Bile Acid Diarrhoea. Springer, 2012.
(Editor), T. C. Northfield, P. Zentler-Munro (Editor), and R. Jazwari (Editor), eds. Bile Acids in Health and Disease: Update on Cholesterol Gallstones and Bile Acid Diarrhoea. Springer, 1988.