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Journal articles on the topic 'ACFDT'

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Author: Grafiati

Published: 14 March 2023

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1

Zhang, Min-Ye, Zhi-Hao Cui, and Hong Jiang. "Relative stability of FeS2polymorphs with the random phase approximation approach." Journal of Materials Chemistry A 6, no. 15 (2018): 6606–16. http://dx.doi.org/10.1039/c8ta00759d.

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2

Everhart, Lucas M., Julio A. Derteano, and Jefferson E. Bates. "Tension between predicting accurate ground state correlation energies and excitation energies from adiabatic approximations in TDDFT." Journal of Chemical Physics 156, no. 8 (February 28, 2022): 084116. http://dx.doi.org/10.1063/5.0080382.

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The connection between the adiabatic excitation energy of time-dependent density functional theory and the ground state correlation energy from the adiabatic connection fluctuation–dissipation theorem (ACFDT) is explored in the limiting case of one excited state. An exact expression is derived for any adiabatic Hartree-exchange–correlation kernel that connects the excitation energy and the potential contribution to correlation. The resulting formula is applied to the asymmetric Hubbard dimer, a system where this limit is exact. Results from a hierarchy of approximations to the kernel, including the random phase approximation (RPA) with and without exchange and the adiabatically exact (AE) approximation, are compared to the exact ones. At full coupling, the numerical results indicate a tension between predicting an accurate excitation energy and an accurate potential contribution to correlation. The AE approximation is capable of making accurate predictions of both quantities, but only in parts of the parameter space that classify as weakly correlated, while RPA tends to be unable to accurately predict these properties simultaneously anywhere. For a strongly correlated dimer, the AE approximation greatly overestimates the excitation energy yet continues to yield an accurate ground state correlation energy due to its accurate prediction of the adiabatic connection integrand. If similar trends hold for real systems, the development of correlation kernels will be important for applications of the ACFDT in systems with large potential contributions to correlation.

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Ma, Zhu, Chengyin Han, Xunda Jiang, Ruihuan Fang, Yuxiang Qiu, Minhua Zhao, Jiahao Huang, Bo Lu, and Chaohong Lee. "Production of ⁸⁷Rb Bose-Einstein Condensate in an Asymmetric Crossed Optical Dipole Trap." Chinese Physics Letters 38, no. 10 (November 1, 2021): 103701. http://dx.doi.org/10.1088/0256-307x/38/10/103701.

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We report the production of 87Rb Bose–Einstein condensate in an asymmetric crossed optical dipole trap (ACODT) without the need of an additional dimple laser. In our experiment, the ACODT is formed by two laser beams with different radii to achieve efficient capture and rapid evaporation of laser cooled atoms. Compared to the cooling procedure in a magnetic trap, the atoms are firstly laser cooled and then directly loaded into an ACODT without the pre-evaporative cooling process. In order to determine the optimal parameters for evaporation cooling, we optimize the power ratio of the two beams and the evaporation time to maximize the final atom number left in the ACODT. By loading about 6 × 105 laser cooled atoms in the ACODT, we obtain a pure Bose–Einstein condensate with about 1.4 × 104 atoms after 19 s evaporation. Additionally, we demonstrate that the fringe-type noises in optical density distributions can be reduced via principal component analysis, which correspondingly improves the reliability of temperature measurement.

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Woźny, Piotr. "Qualitative analysis of maintenance and services carried out in a repair plant on the example of a multi-purpose aircraft." Journal of KONBiN 36, no. 1 (December 1, 2015): 165–74. http://dx.doi.org/10.1515/jok-2015-0065.

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Abstract The article presents revealed failures and damages of the multi-task aircraft (ACFT) reported by users to the service organization, aimed at assessing and removing them. In the course of the analysis process, damages and malfunctions were grouped, depending on aviation specialities. A review was conducted that targeted occurring malfunctions and damages in a set of ACFT of the same type, over a twelve-year operational period. In the assessed period, trend lines were determined, showing a drop in the number of accepted claims submitted by ACFT users.

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Maldonado Araya, Felipe, Mauricio Campos Pardo, Andrea García Prado, and María Angélica Cereceda Miranda. "Perfil facial blando y relación distal de segundos molares en niños con dentición primaria completa." Odontología Sanmarquina 22, no. 3 (September 12, 2019): 173–79. http://dx.doi.org/10.15381/os.v22i3.16706.

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Objetivo. Evaluar los tipos de perfil facial blando mediante los ángulos de convexidad facial (ACF) y convexidad facial total (ACFT) y su relación con la posición distal de los segundos molares primarios en niños entre 3 y 5 años. Métodos. Estudio transversal en 28 niños chilenos con al menos un apellido de origen español y dentición primaria completa, quienes cumplían con los requisitos del estudio. Para evaluar el ACF y ACFT se tomó fotografía digital estandarizada del perfil lateral. Con la prueba exacta de Fisher se comparó los perfiles blandos según edad y género, y con t de Student para muestra única se evaluó los promedios angulares. Resultados. Para el ACF la media fue 167,1° ± 5,1, y para ACFT 145,8° ± 3,7. Se observó convexidad alta del ACF en 21,4% de los niños, media en 60,7% y baja en 17,9%; y para el ACFT en 17,9%, 67,9% y 14,2% respectivamente. El promedio del ACF para la relación molar escalón mesial, plano vertical y escalón distal fue de 169,2° ± 3.7, 168° ± 4,9 y 162,5°±4,8, mientras que para ACFT fue 146,7° ± 4,4, 146,3° ± 3,6 y 143,5° ± 2,8 respectivamente. Conclusiones. Se observó para ACF relación significativa entre la presencia de perfil convexo alto y escalón distal, además de diferencia significativa entre el promedio de este ángulo en escalón distal en comparación al promedio de referencia. El ACF puede ser indicador aceptable de escalón distal, sin embargo, no es certero al evaluar un plano vertical o escalón mesial.

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Heinrich, Katie M., Aspen E. Streetman, Filip Kukić, Chunki Fong, Brittany S. Hollerbach, Blake D. Goodman, Christopher K. Haddock, and Walker S. C. Poston. "Baseline Physical Activity Behaviors and Relationships with Fitness in the Army Training at High Intensity Study." Journal of Functional Morphology and Kinesiology 7, no. 1 (March 8, 2022): 27. http://dx.doi.org/10.3390/jfmk7010027.

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United States Army soldiers must meet physical fitness test standards. Criticisms of the Army Physical Fitness Test (APFT) include limited testing of only aerobic and muscular endurance activity domains; yet, it is unclear what levels of aerobic and muscle strengthening activity may help predict performance in aspects of the new Army Combat Fitness Test (ACFT). This study explored relationships between baseline self-reported aerobic and muscle strengthening activities and APFT- and ACFT-related performance. Baseline participant data (N = 123) were from a cluster-randomized clinical trial that recruited active-duty military personnel (mean age 33.7 ± 5.7 years, 72.4% White, 87.0% college-educated, 81.5% Officers). An online survey was used for self-report of socio-demographic characteristics and weekly aerobic and muscle-strengthening physical activity behaviors. Participants also completed the APFT (2 min push-ups, 2 min sit-ups, 2-mile run) and ACFT-related measures (1-repetition maximum deadlift, pull-up repetitions or timed flexed arm hang, horizontal jump, and dummy drag). Bivariate logistic regression found greater aerobic and muscle-strengthening activity predicted better APFT performance, while better ACFT-related performance was predicted by greater muscle-strengthening activity. Although our data are mostly from mid-career officers, command policies should emphasize the new Holistic Health and Fitness initiative that encourages regular aerobic and muscle-strengthening physical activity for soldiers.

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Ratnayake, Irushi, Susannah Ahern, and Rasa Ruseckaite. "Acceptability of patient reported outcome measures (PROMs) in a cystic fibrosis data registry." BMJ Open Respiratory Research 8, no. 1 (July 2021): e000927. http://dx.doi.org/10.1136/bmjresp-2021-000927.

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IntroductionImprovements in the treatment of cystic fibrosis (CF) have resulted in longer survival and an increased focus on optimising daily functioning with the condition. Patient-reported outcome measures (PROMs) are valuable tools in evaluating the health-related quality of life of persons with chronic diseases. PROMs may be incorporated into clinical registries to assess and provide feedback regarding the health-related quality of life of the affected population. This study uses qualitative methodology to describe the views of patients with CF, caregivers and clinicians on the usefulness and practicality of incorporating a PROM in the Australian Cystic Fibrosis Data Registry (ACFDR).MethodsWe conducted semistructured interviews with a convenience sample of patients with CF (n=5), caregivers (n=7) and clinicians (n=13) on their opinions on incorporating the Cystic Fibrosis Questionnaire-Revised or the Cystic Fibrosis Quality of Life Questionnaire into the ACFDR. We analysed data into topics and subtopics using conventional content analysis.ResultsParticipants believed that PROMs could generate useful aggregate health-related quality of life data to support better understanding of the experiences of the modern CF population. Participants emphasised that implementation must be supported by processes to feedback data to patients and clinicians. Most participants preferred electronic PROMs administration for easy integration into existing systems and the potential to support feedback.ConclusionPatients, caregivers and clinicians in this study generally supported the usefulness and practicality of PROM implementation in the ACFDR.

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Ratnayake, Irushi, Susannah Ahern, and Rasa Ruseckaite. "Patient-Reported Outcome Measures in Cystic Fibrosis: Protocol for a Systematic Review." JMIR Research Protocols 9, no. 5 (May 6, 2020): e15467. http://dx.doi.org/10.2196/15467.

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Background Patients with cystic fibrosis (CF) can struggle with burdensome symptoms and treatment regimens that negatively affect every aspect of their life. As physiological parameters can fail to capture these complications, the assessment of health-related quality of life (HRQOL) has gained prominence. HRQOL can be measured using standardized patient questionnaires called patient-reported outcome measures (PROMs). The Australian Cystic Fibrosis Data Registry (ACFDR) collects clinical data on adult and pediatric patients with CF. The incorporation of PROMs into the ACFDR would enable monitoring of HRQOL trends, benchmarking of HRQOL outcomes, and support of HRQOL research in CF. Objective Prior to incorporation of a PROM in the ACFDR, this systematic review was planned to evaluate whether any suitable PROMs are currently being used for CF. Methods This systematic review will be conducted in compliance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) guidelines. MEDLINE, EMBASE, Scopus, CINAHL (Cumulative Index of Nursing and Allied Health Literature), PsycINFO, and Cochrane Library databases were searched for articles published between January 2009 and February 2019 on the use of PROMs to measure HRQOL in adult and pediatric patients with CF. Study designs such as observational studies, reviews and validation studies were included. Studies describing randomized controlled trials, dissertations, books, guideline statements, and abstracts were excluded. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) risk of bias checklist was used to assess the methodological quality of included studies. A descriptive synthesis of the results will be undertaken in line with the outcomes of this study. Results As of July 2019, the search has been conducted and 4530 records were screened. After two phases of screening, 97 studies were included in the final review and subjected to data extraction. Reviewers are currently in the process of critical appraisal. Conclusions This review will identify any PROM(s) that may be used to measure HRQOL in the ACFDR. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42019126931; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=126931

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Tolinacki, Maja, Jelena Lozo, Katarina Veljovic, Milan Kojic, Djordje Fira, and Ljubisa Topisirovic. "Examination of antimicrobial potential in natural isolates of lactobacillus casei/paracasei group." Genetika 44, no. 3 (2012): 661–77. http://dx.doi.org/10.2298/gensr1203661t.

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The aim of this study was to investigate the antimicrobial potential of 52 natural isolates of Lactobacillus casei/paracasei. The incidence of relevant genes encoding BacSJ (bacSJ2-8/bacSJ2-8i gene cluster), acidocin 8912 (acdT), ABC-transporter (abcT) and accessory protein (acc) was also studied. These genes were found to be widespread amongst the analyzed L. casei/paracasei strains. The bacSJ2-8/bacSJ2-8i gene cluster was present in 49 (94.23%) and acdT in 41 (78.85%) of the 52 tested strains. Forty of these strains (76.92%) harbored both analyzed genes. Interestingly, only 17 strains (32.69%) with the bacSJ2-8/bacSJ2-8i gene cluster and/or the acdT gene showed bacteriocin production. Strain L. paracasei BGNK1-62 contained the bacSJ2-8/bacSJ2-8i gene cluster, but did not produce bacteriocin BacSJ possibly due to absence of the abcT and acc genes. Hence, these genes were introduced into BGNK1-62 by transformation with constructed plasmid pA2A, after which BacSJ was produced. In addition, it was found that L. paracasei BGGR2-66 produced new bacteriocin designated as BacGR that was biochemically characterized and its N- terminal sequence was determined.

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Duy Tran, Anh, Somjit Arch-int, and Ngamnij Arch-int. "Approximation Measures for Conditional Functional Dependencies Using Stripped Conditional Partitions." International Journal of Electrical and Computer Engineering (IJECE) 7, no. 3 (June 1, 2017): 1385. http://dx.doi.org/10.11591/ijece.v7i3.pp1385-1397.

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Conditional functional dependencies (CFDs) have been used to improve the quality of data, including detecting and repairing data inconsistencies. Approximation measures have significant importance for data dependencies in data mining. To adapt to exceptions in real data, the measures are used to relax the strictness of CFDs for more generalized dependencies, called approximate conditional functional dependencies (ACFDs). This paper analyzes the weaknesses of dependency degree, confidence and conviction measures for general CFDs (constant and variable CFDs). A new measure for general CFDs based on incomplete knowledge granularity is proposed to measure the approximation of these dependencies as well as the distribution of data tuples into the conditional equivalence classes. Finally, the effectiveness of stripped conditional partitions and this new measure are evaluated on synthetic and real data sets. These results are important to the study of theory of approximation dependencies and improvement of discovery algorithms of CFDs and ACFDs.

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11

Cenko, A., and M. Lutton. "ACFD applications to store separation — status report." Aeronautical Journal 104, no. 1040 (October 2000): 459–66. http://dx.doi.org/10.1017/s0001924000091958.

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During the past decade, the Navy has considerably improved its capabilities in aircraft-weapon integration. In 1989 it took more than 400 hours of wind-tunnel testing, which cost $1,5000,000, and 20 flights to clear the JSOW from the F-18 to Mach 0·95. This year the Mk-83 JDAM was cleared after only 60 hours of wind-tunnel testing and five flights to the full F-18 aircraft envelope of Mach 1·3. This reduction occurred because the Navy not only learned to test smarter, but also developed an integrated approach to modelling and simulation (M&S), wind-tunnel and flight testing which allowed lessons learned on previous programmes to be applied to new ones. However, the present approach still requires a fairly large commitment of time and financial resources to accomplish the mission. The present approach has optimised the use of available resources; any further gains will have to come not by improving existing techniques, but by bringing new resources into the process.

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Huang, Hanqiao, Yufei Zha, Meiyun Zheng, and Peng Zhang. "ACFT: adversarial correlation filter for robust tracking." IET Image Processing 13, no. 14 (December 12, 2019): 2687–93. http://dx.doi.org/10.1049/iet-ipr.2018.6672.

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Smith, M., and C. Laenen. "Inspection of nuclear storage tanks using remotely deployed ACFMT." Insight - Non-Destructive Testing and Condition Monitoring 49, no. 1 (January 2007): 17–20. http://dx.doi.org/10.1784/insi.2007.49.1.17.

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14

Eleftherakis, John G., and Abraham Khalil. "Multipass Beta Filtration Testing for the 21st Century." International Nonwovens Journal os-9, no. 3 (September 2000): 1558925000OS—90. http://dx.doi.org/10.1177/1558925000os-900308.

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The current ISO 4572 Multipass Filter Test Procedure has not been substantially revised since its approval as an ISO document in 1981. However, proposed revisions will likely be adopted shortly which will have far-reaching impact in liquid multipass filter testing and for virtually all industrial applications. These revisions include the adoption of a new test dust to replace the discontinued AC Fine Test Dust (ACFTD), a revised particle counter calibration procedure using National Institute of Standards & Technology (NIST) traceable calibration fluid, a new on-line particle counter, sample delivery and dilution system validation procedure, and a new reporting format. These changes result in a new definition for assessing and rating filter performance. This paper discusses these changes in detail and the resulting impact on the filtration industry. For example, the most significant revision pertains to use of a revised ISO 4402 standard for calibration of liquid particle counters. Until now, particle counter calibration fluid containing ACFTD was used to calibrate particle counters. This test dust is no longer manufactured due, in part, to the inability of the manufacturer to produce a consistent particle distribution of ACFTD from one batch to another. This inconsistency in the test dust, and also in much of the calibration fluid containing the test dust, created a great challenge for labs to correlate particle count results and filter test data. The revised ISO 4402 calibration standard will require the use of a new NIST Standard Reference Material (SRM) calibration fluid using a new test dust called ISO Medium dust, which has virtually replaced ACFTD. This new test dust and the calibration fluid containing it is much more consistent and reliable, allowing for better correlation of results. The analysis conducted by NIST to certify the calibration fluid as a SRM found what before was defined as a 2 micron particle was actually a 4.6 micron particle and what was defined as a 15 micron particle was actually a 13.6 micron particle. This finding will redefine liquid filter performance information based on particle counts to the effect that, in general, fine filters will appear less efficient than previously reported and coarse filters will appear more efficient. While other revisions to ISO 4572 will have less impact, they are presented. Filter test engineers, filter users and manufacturers, and filter sales personnel will benefit by educating themselves now on the impact of these revisions in order to best serve the filtration industry and filter users.

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Laborda, Eduardo, José Manuel Olmos, and Ángela Molina. "Transfer of complexed and dissociated ionic species at soft interfaces: a voltammetric study of chemical kinetic and diffusional effects." Physical Chemistry Chemical Physics 18, no. 15 (2016): 10158–72. http://dx.doi.org/10.1039/c6cp00780e.

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The ACDT mechanism is considered in which two different ionic species of the same charge can be transferred across a soft interface while they interconvert each other through a homogeneous chemical reaction.

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Erhard, Jannis, Steffen Fauser, Simon Kalaß, Evgeny Moerman, Egor Trushin, and Andreas Görling. "Lieb–Oxford bound and pair correlation functions for density-functional methods based on the adiabatic-connection fluctuation-dissipation theorem." Faraday Discussions 224 (2020): 79–97. http://dx.doi.org/10.1039/d0fd00047g.

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Compliance with the Lieb–Oxford bound is investigated for density-functional methods based on the ACFD theorem to treat correlation. Correlation pair densities resulting from such methods are compared with highly accurate reference values.

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Molina, Ángela, José Manuel Olmos, Eduardo Laborda, José María Gómez-Gil, and Joaquín González. "Voltammetry of the aqueous complexation–dissociation coupled to transfer (ACDT) mechanism with charged ligands." Physical Chemistry Chemical Physics 18, no. 25 (2016): 17091–104. http://dx.doi.org/10.1039/c6cp03032g.

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The voltammetry of the ACDT mechanism shows different responses depending on whether the ligand species is neutral or charged. Analytical solutions are deduced to calculate the current–potential signal and gain insight into the physicochemical processes behind it.

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Withey, Jeffrey H., and Victor J. DiRita. "Vibrio cholerae ToxT Independently Activates the Divergently Transcribed aldA and tagA Genes." Journal of Bacteriology 187, no. 23 (December 1, 2005): 7890–900. http://dx.doi.org/10.1128/jb.187.23.7890-7900.2005.

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ABSTRACT The Vibrio cholerae ToxT regulon includes the genes encoding cholera toxin (CT) and the toxin-coregulated pilus (TCP), which are the major virulence factors required for causing cholera disease and colonizing the upper small intestine of the host, respectively. The genes encoding CT, ctxAB, and the genes encoding the components of the TCP, tcpA to tcpJ, are organized within operons, upstream of which are DNA binding sites for the transcriptional activator ToxT. ToxT is a member of the large AraC/XylS family of transcriptional regulators and also activates transcription of five other genes whose roles in V. cholerae pathogenesis, if any, are poorly understood. acfA and acfD are divergently transcribed genes required for efficient colonization of the intestine. Transcriptional activation of acfA and acfD requires a pair of central ToxT binding sites in an inverted-repeat configuration for ToxT-directed transcription of both genes. tcpI has an unknown role in pathogenesis. aldA and tagA are divergently transcribed genes that also have unknown roles in pathogenesis. In this study, we map the aldA and tagA promoters and identify the ToxT binding sites upstream of each gene. Our results suggest that two ToxT binding sites in an inverted-repeat configuration are required for ToxT-directed transcription of tagA and that a single ToxT binding site is required for ToxT-directed transcription of aldA. Furthermore, to direct transcription of tagA and aldA, ToxT uses independent binding regions upstream of each gene, in contrast to what we previously found for the divergently transcribed acfA and acfD genes, which share ToxT binding sites between the two genes.

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Karabulut, Utku Cem, Yavuz Hakan Özdemir, and Barış Barlas. "ACFD Study On the Hydrodynamic Characteristics of the Antifouling Paints." Journal of ETA Maritime Science 7, no. 4 (2019): 318–31. http://dx.doi.org/10.5505/jems.2019.63644.

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Flores Cervantes, Mtra Claudia, and Dra Alma Alicia Benítez Pérez. "Prueba cognitiva–cuantitativa para identificar el Acercamiento Comunicativo Dialógico Textual del docente." CPU-e, Revista de Investigación Educativa, no. 23 (July 6, 2016): 45–74. http://dx.doi.org/10.25009/cpue.v0i23.2159.

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Este artículo tiene como objetivo proponer una prueba cognitiva–cuantitativa para identificar el Acercamiento Comunicativo Dialógico Textual en el docente de nivel medio superior con relación al texto científico, a partir de la elaboración de una rúbrica integrada por categorías (dimensiones cognitivas) y niveles de comprensión de lectura, al tiempo de ser una base para la elaboración de ítems. Actualmente la prueba se encuentra en etapa diagnóstica y es de corte cuantitativo no probabilístico. Los primeros resultados señalan que sí es posible identificar el ACDT, justo donde la decodificación que realiza el sujeto sobre el objeto textual, determina la profundidad del diálogo y la adquisición del conocimiento científico en torno al mensaje. AbstractThe objective of this article is to propose a cognitive–quantitative test to identify the Dialogic–Textual Communicative Approach Of the upper middle education's teaching staff about scientific texts, from a rubric integrated by categories (cognitive dimensions) and reading comprehension levels. It's important to mention that this rubric was also used to elaborate the items. Currently the test is on a quantitative not probabilistic diagnosis stage. The first results conclude that certainly the ACDT, can be identifiable, where the decoding that the subject is doing about the textual object, determines the depth of the dialogue and the scientific knowledge acquisition about the message. Recibido: 17 de agosto de 2015 Aceptado: 01 de marzo de 2016

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Shariff, Muhammad Zahid Firdaus, Normayati Nordin, Lim Chia Chun, Shamsuri Mohamed Rasidi, Raudhah Othman, and Sharifah Adzila. "Development of Performance Correlations using ACFD Method for 2-D Curved Diffuser." CFD Letters 12, no. 8 (August 30, 2020): 1–16. http://dx.doi.org/10.37934/cfdl.12.8.116.

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Balaji, C., and H. Herwig. "THE USE OF ACFD APPROACH PROBLEMS INVOLVING SURFACE RADIATION AND FREE CONVECTION." International Communications in Heat and Mass Transfer 30, no. 2 (March 2003): 251–59. http://dx.doi.org/10.1016/s0735-1933(03)00036-8.

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Kuo, Ping-Chang, Dennis A. Brown, Barbara A. Scofield, Hallel C. Paraiso, Pei-Yu Wang, I.-Chen Yu, and Jui-Hung Yen. "Dithiolethione ACDT suppresses neuroinflammation and ameliorates disease severity in experimental autoimmune encephalomyelitis." Brain, Behavior, and Immunity 70 (May 2018): 76–87. http://dx.doi.org/10.1016/j.bbi.2018.03.010.

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Ratnayake, Irushi, Susannah Ahern, and Rasa Ruseckaite. "A systematic review of patient-reported outcome measures (PROMs) in cystic fibrosis." BMJ Open 10, no. 10 (October 2020): e033867. http://dx.doi.org/10.1136/bmjopen-2019-033867.

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BackgroundTo determine patient-reported outcome measures (PROMs) which may be suitable for incorporation into the Australian Cystic Fibrosis Data Registry (ACFDR) by identifying PROMs administered in adult and paediatric cystic fibrosis (CF) populations in the last decade.MethodsWe searched MEDLINE, EMBASE, Scopus, CINAHL, PsycINFO and Cochrane Library databases for studies published between January 2009 and February 2019 describing the use of PROMs to measure health-related quality of life (HRQoL) in adult and paediatric patients with CF. Validation studies, observational studies and qualitative studies were included. The search was conducted on 13 February 2019. The COnsensus-based Standards for the selection of health Measurement INstruments Risk of Bias Checklist was used to assess the methodological quality of included studies.ResultsTwenty-seven different PROMs were identified. The most commonly used PROMs were designed specifically for CF. Equal numbers of studies were conducted on adult (32%, n=31), paediatric (35%, n=34) and both (27%, n=26) populations. No PROMs were used within a clinical registry setting previously. The two most widely used PROMs, the Cystic Fibrosis Questionnaire—Revised (CFQ-R) and the Cystic Fibrosis Quality of Life Questionnaire (CFQoL), demonstrated good psychometric properties and acceptability in English-speaking populations.DiscussionWe found that although PROMs are widely used in CF, there is a lack of reporting on the efficacy of methods and timepoints of administration. We identified the CFQ-R and CFQoL as the most suitable for incorporation in the ACFDR as they captured significant effects of CF on HRQoL and were reliable and valid in CF populations. These PROMs will be used in a further qualitative study assessing patients’ with CF and clinicians’ perspectives toward the acceptability and feasibility of incorporating a PROM in the ACFDR.PROSPERO registration numberCRD42019126931.

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Balaji, C., M. Hölling, and H. Herwig. "Combined Laminar Mixed Convection and Surface Radiation using Asymptotic Computational Fluid Dynamics (ACFD)." Heat and Mass Transfer 43, no. 6 (June 9, 2006): 567–77. http://dx.doi.org/10.1007/s00231-006-0145-3.

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Babatunde, B. B., and R. A. Hamzat. "Effects of graded levels of kolanut husk on the performance of cockerels." Nigerian Journal of Animal Production 32, no. 1 (January 1, 2021): 61–66. http://dx.doi.org/10.51791/njap.v32i1.1035.

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Eighty black Nera cockerel chicks were randomly alloted to four dietarey treatmants containing 0, 10, 20 and 30% kolanut husk meal (KHM) for twelve weeks. Significant differences (P<0.05) in feed intake, weight gain and feed conversion ratio were observed. Dietary inclusion of KHM depressed (P<0.05) growth rate feed conversion ratio and nutrition uilization of cockerels birds. There were linear reduction (P>0.05) in nitrogen retention and apparent crude fibre digestibility (ACFD) of cockerels birds at each incremental KHM dietary levels. This indicated that KHM could be effeciently utilized by cockerels up to 205 dietary level above which the depression in growth rate occurs.

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Kulkarni, Neha, Rajitha Gadde, Kuljeet S. Gugnani, Nguyen Vu, Claude Yoo, Rohan Zaveri, and Swati Betharia. "Neuroprotective effects of disubstituted dithiolethione ACDT against manganese-induced toxicity in SH-SY5Y cells." Neurochemistry International 147 (July 2021): 105052. http://dx.doi.org/10.1016/j.neuint.2021.105052.

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Balaji, C., M. Hölling, and H. Herwig. "A general methodology for treating mixed convection problems using asymptotic computational fluid dynamics (ACFD)." International Communications in Heat and Mass Transfer 34, no. 6 (July 2007): 682–91. http://dx.doi.org/10.1016/j.icheatmasstransfer.2007.03.006.

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González, P. C. Meléndez, Sagrario M. Montemayor, D. Morales Acosta, Y. Verde-Gómez, B. Escobar, and F. J. Rodríguez Varela. "Enhanced Catalytic Activity for the Ethanol Oxidation Reaction (EOR) using Novel Pt-Fe3O4/MWCNT Bimetallic Electrocatalyst." Journal of New Materials for Electrochemical Systems 17, no. 2 (April 15, 2014): 067–70. http://dx.doi.org/10.14447/jnmes.v17i2.425.

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In this work, 20% Pt-Fe3O4/MWCNT (Pt:Fe3O4 weight ratio of 80:20) and 20% Pt/MWCNT nanoparticles were synthesized and characterized as anode electrocatalysts in H2SO4 media. First, the electrocatalyst were submitted to accelerated catalyst degradation test (ACDT) by performing 500 cycles between 0.6 and 1.2 V (vs. SHE). Then, their performance for the EOR was evaluated. The magnetite-containing nanoparticles demonstrated to be highly electrochemically stable, with negligible surface area losses (less than 7%) in thehydrogen adsorption/desorption region. Moreover, Pt-Fe3O4/MWCNT showed a significantly enhanced catalytic activity for the EOR when compared to Pt/MWCNT, with almost 46% increase in current density when using Fe3O4 as co-catalysts.

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Zaveri, Rohan Purvin, Rajitha Gadde, and Swati Betharia. "Modulation of Apoptosis by the Dithiolethione ACDT as a Neuroprotective Mechanism Against Manganese‐Induced Toxicity." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.02329.

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Tawabini, Bassam, Mubarak Al-Enazi, Mansour A. Alghamdi, Ashraf Farahat, Ahsan M. Shemsi, Marwan Y. Al Sharif, and Mamdouh I. Khoder. "Potentially Harmful Elements Associated with Dust of Mosques: Pollution Status, Sources, and Human Health Risks." International Journal of Environmental Research and Public Health 20, no. 3 (February 2, 2023): 2687. http://dx.doi.org/10.3390/ijerph20032687.

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Potentially harmful elements (PHEs) associated with dust generated from anthropogenic sources can be transported into mosques and deposited on the filters of the air-conditioners (AC); thereby, children and adults are exposed to such PHEs while visiting mosques. Data dealing with the assessment of PHEs pollution and its human health risk in mosques dust in Saudi Arabia are scarce. Therefore, this work aims to examine the levels and pollution status of PHEs in AC filter dust (ACFD) of mosques and their associated human health risk in three Saudi cities: Jubail, Jeddah, and Dammam metropolitan. A similar concentration pattern of PHEs is observed in three cities’ mosques with noticeably higher concentrations than both global crustal and local background values for Zn, Cu, Pb, As, and Cd only. Except for Fe, Al, and Mn, the highest PHEs concentrations were found in Jeddah (1407 mg/kg), followed by Dammam (1239 mg/kg) and Jubail (1103 mg/kg). High PHEs’ concentrations were also recorded in mosques located near workshops and suburban areas compared to urban areas. Based on the spatial pattern, enrichment factor, geo-accumulation index, pollution load index, and ecological risk values, Jubail, Jeddah, and Dammam have shown moderate pollution levels of Cd, As, Pb, and Zn. On the other hand, Cu. Zn, Cu, Cr, Pb, Ni, As, and Cd had degrees of enrichment levels that varied from significantly enriched to extremely highly enriched in the ACFD of the three cities. Heavy pollution is found in Jubail, which posed a higher potential ecological risk than in Jeddah and Dammam. Cd presents the highest ecological risk factors (ER) in the three cities. Carcinogenic and non-carcinogenic risks for children and adults follow the order: Jeddah > Dammam > Jubail, and the ingestion pathway was the main route for exposure. Carcinogenic and con-carcinogenic risks in the mosques of the various studied cities were generally within the acceptable range.

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Kulkarni, Neha, and Swati Betharia. "Neuroprotective Potential of Dithiolethiones D3T And ACDT Against Iron Overload‐Induced Toxicity in Human Glioblastoma Cells." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.03144.

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Betharia, Swati, Alejandro N. Rondόn-Ortiz, and Dennis A. Brown. "Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells." Neurochemical Research 44, no. 8 (June 4, 2019): 1878–92. http://dx.doi.org/10.1007/s11064-019-02823-3.

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Nagel, Leila, Kerstin E. Krall, and Bernd Jähne. "Measurements of air–sea gas transfer velocities in the Baltic Sea." Ocean Science 15, no. 2 (March 8, 2019): 235–47. http://dx.doi.org/10.5194/os-15-235-2019.

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Abstract. Heat transfer velocities measured during three different campaigns in the Baltic Sea using the active controlled flux technique (ACFT) with wind speeds ranging from 5.3 to 14.8 m s−1 are presented. Careful scaling of the heat transfer velocities to gas transfer velocities using Schmidt number exponents measured in a laboratory study allows us to compare the measured transfer velocities to existing gas transfer velocity parameterizations, which use wind speed as the controlling parameter. The measured data and other field data clearly show that some gas transfer velocities are much lower than those based on the empirical wind speed parameterizations. This indicates that the dependencies of the transfer velocity on the fetch, i. e., the history of the wind and the age of the wind-wave field, and the effects of surface-active material need to be taken into account.

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Midasala, Vasujadevi, Krishna Chaitanya Janapati, Sirasanagondla Venkata Naga Srinivasu, Manikandan Ramachandran, Mehdi Mousavi, and Amir H. Gandomi. "Sensor-System-Based Network with Low-Power Communication Using Multi-Hop Routing Protocol Integrated with a Data Transmission Model." Electronics 11, no. 10 (May 11, 2022): 1541. http://dx.doi.org/10.3390/electronics11101541.

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Wireless sensor networks (WSNs) comprise several cooperating sensor nodes capable of sensing, computing, and transmitting sensed signals to a central server. This research proposes a sensor system-based network with low power communication using swarm intelligence integrated with multi-hop communication (SIMHC). This routing protocol selects the optimal route based on link distance, transmission power, and residual energy to optimize the network lifetime and node energy efficiency. Moreover, adaptive clustering-based locative data transmission (ACLDT) is applied for optimizing data transmission. The proposed approach combines clustering with data transfer via location-based routing and low-power communication in two phases to calculate the ideal cluster heads (CHs). First, a CH seeks the next hop from the nearest CH. Then, a path to the base station is formed by developing CH chains. The results reveal that the proposed sensor system based on data transmission and low-power consumption achieved a network lifetime of 96%, an average delay of 53 ms, a coverage rate (CR) of 83%, a throughput of 97%, and energy efficiency of 95%.

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Sax van der Weyden, Megan, Michael Toczko, Marcie Fyock-Martin, and Joel Martin. "Relationship between a Maximum Plank Assessment and Fitness, Health Behaviors, and Moods in Tactical Athletes: An Exploratory Study." International Journal of Environmental Research and Public Health 19, no. 19 (October 7, 2022): 12832. http://dx.doi.org/10.3390/ijerph191912832.

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A maximum plank hold (PH) has been implemented in the Army Combat Fitness Test (ACFT) with the Holistic Health and Fitness (H2F) program. The H2F program introduces a shift in wellbeing from a fitness centered approach to framework also comprising nutrition, sleep, mental, and spiritual components. The purpose was to analyze how a maximum PH correlated with fitness, lifestyle behaviors, and mood states in tactical athletes (TA) and assess differences between those who pass and fail. Forty-nine TA completed fitness testing, lifestyle behavior, and mood state surveys. Bivariate correlations were used to examine relationships with PH performance. PH time was significantly correlated with total body mass, fat mass, BMI, push-ups, and state physical energy (SPE). VO2max was significantly different between the groups who passed and failed the PH. PH was not associated with lifestyle behaviors or trait mood states. PH performance could vary day-to-day as it was correlated with SPE. Individuals with poorer aerobic fitness and body composition may be at risk for failing the PH.

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Olmos, José Manuel, Eduardo Laborda, and Angela Molina. "Differential double pulse voltammetry (DDPV) and additive differential pulse voltammetry (ADPV) applied to the study of the ACDT mechanism." Journal of Solid State Electrochemistry 24, no. 11-12 (July 4, 2020): 2819–31. http://dx.doi.org/10.1007/s10008-020-04619-w.

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Parsot, C., and J. J. Mekalanos. "Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression." Journal of Bacteriology 174, no. 16 (1992): 5211–18. http://dx.doi.org/10.1128/jb.174.16.5211-5218.1992.

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Cohen Hubal, Elaine A., Julia S. Kimbell, and Peter S. Fedkiw. "Incorporation of Nasal-Lining Mass-Transfer Resistance into Acfd Model for Prediction of Ozone Dosimetry in the Upper Respiratory Tract." Inhalation Toxicology 8, no. 9 (January 1996): 831–57. http://dx.doi.org/10.3109/08958379609034267.

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Jaya Krishna, D., Tanmay Basak, and Sarit K. Das. "Non-Darcy buoyancy driven flows in a fluid saturated porous medium: the use of asymptotic computational fluid dynamics (ACFD) approach." Heat and Mass Transfer 44, no. 9 (October 25, 2007): 1117–25. http://dx.doi.org/10.1007/s00231-007-0348-2.

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Moss, Sarah M. A., Tianchi Wang, Charlotte Voogd, Lara A. Brian, Rongmei Wu, Roger P. Hellens, Andrew C. Allan, Joanna Putterill, and Erika Varkonyi-Gasic. "AcFT promotes kiwifruit in vitro flowering when overexpressed and Arabidopsis flowering when expressed in the vasculature under its own promoter." Plant Direct 2, no. 7 (July 2018): e00068. http://dx.doi.org/10.1002/pld3.68.

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Yuniargo, Flaviana Agustiani, and Senny Harindahyani. "PENGARUH GENDER FINANCIAL EXPERTISE KOMITE AUDIT TERHADAP PRAKTIK MANAJEMEN LABA PERUSAHAAN NON-KEUANGAN YANG TERDAFTAR DI BEI PERIODE 2016-2018." Akuntansi dan Teknologi Informasi 14, no. 2 (September 30, 2021): 66–86. http://dx.doi.org/10.24123/jati.v14i2.4658.

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Earnings management is a manager's choice to choose accounting policies or real actions to achieve certain earnings goals. This study aims to examine the effect of the gender financial expertise of the audit committee on earnings management practices. This study uses 852 samples of non-financial companies listed on the Indonesia Stock Exchange in 2016-2018 by using multiple linear regression analysis with classical assumption testing. The result of this study is the indication that committee audit financial expertise (EXPERT), proportion of the number of women on the audit committee (ACFD), and proportion of female financial experts on the audit committee (FEMEX) do not have a significant influence on earnings management as measured by using discretionary accruals. On the contrary, the proportion of male financial experts on the audit committee (MALEX), has a significant positive effect on earnings management. This shows that the presence of financial expertise that affects earnings management has been influenced by the sex of male financial experts. This research is in accordance with the theory that reveals that there are different effects with the existence of gender differences in a company.

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Stypinska, Barbara, Anna Wajda, Ewa Walczuk, Marzena Olesinska, Aleksandra Lewandowska, Marcela Walczyk, and Agnieszka Paradowska-Gorycka. "The Serum Cell-Free microRNA Expression Profile in MCTD, SLE, SSc, and RA Patients." Journal of Clinical Medicine 9, no. 1 (January 7, 2020): 161. http://dx.doi.org/10.3390/jcm9010161.

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Mixed connective tissue disease (MCTD) is a rare disorder characterized by symptoms that overlap two or more Autoimmune Connective Tissue Diseases (ACTDs). The aim of this study was to determine whether miRNAs participating in the TLRs signaling pathway could serve as biomarkers differentiating MCTD or other ACTD entities from a healthy control group and between groups of patients. Although the selected miRNA expression level was not significantly different between MCTD and control, we observed that miR-126 distinguishes MCTD patients from all other ACTD groups. The expression level of miRNAs was significantly higher in the serum of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients compared to controls. The miR-145 and -181a levels distinguished RA from other ACDT patients. miR-155 was specific for SLE patients. MiR-132, miR-143, and miR-29a distinguished RA and SLE patients from the systemic sclerosis (SSc) group. Additionally, some clinical parameters were significantly related to the miRNA expression profile in the SLE group. SLE and RA are characterized by a specific serum expression profile of the microRNAs associated with the Toll-like receptors (TLRs) signaling pathway. The analysis showed that their level distinguishes these groups from the control and from other ACTD patients. The present study did not reveal a good biomarker for MCTD patients.

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Withey, Jeffrey H., and Victor J. DiRita. "Activation of both acfA and acfD transcription by Vibrio cholerae ToxT requires binding to two centrally located DNA sites in an inverted repeat conformation." Molecular Microbiology 56, no. 4 (March 9, 2005): 1062–77. http://dx.doi.org/10.1111/j.1365-2958.2005.04589.x.

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Rydock, James P., and Brian K. Lamb. "A Continuous Fast-Response Dual-Tracer Analyzer for Halogenated Atmospheric Tracer Studies." Journal of Atmospheric and Oceanic Technology 11, no. 5 (October 1994): 1262–72. http://dx.doi.org/10.1175/1520-0426(1994)011<1262:acfrdt>2.0.co;2.

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Hodges, K. I. "Adaptive Constraints for Feature Tracking." Monthly Weather Review 127, no. 6 (June 1999): 1362–73. http://dx.doi.org/10.1175/1520-0493(1999)127<1362:acfft>2.0.co;2.

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Malpica Castillo, Luis E., Shannon Palmer, Anqi Zhu, Allison Deal, Sheh-Li Chen, and Stephan Moll. "Adherence to Infectious Disease Screening and Immunization Guidelines When Treating Non-Malignant Immune-Mediated Hematologic Disorders." Blood 134, Supplement_1 (November 13, 2019): 792. http://dx.doi.org/10.1182/blood-2019-121340.

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Background : The use of immunosuppressive therapies in the management of non-malignant immune-mediated hematologic disorders (NMIHD) leads to an increased risk of infections. Preventive strategies, such as immunization and infectious disease (ID) screening, reduce the burden of infectious complications. However, lack of compliance to available guidelines among healthcare providers (HCP) represent a major concern. The present study was performed to assess adherence by HCP to national guidelines and recommendations for the prevention of infectious complications in patients (pts) treated for a NMIHD with the goal to identify areas where interventions can be implemented to improve awareness. Methods : We retrospectively analyzed pts diagnosed with AIHA, acquired coagulation factor deficiency (ACFD), TTP, ITP, aHUS, PNH, and antiphospholipid syndrome (APS) between January 2016 and July 2018 at an academic medical center (University of North Carolina). Pts had to have received either rituximab (RTX), eculizumab, or splenectomy. Adherence to existing strategies was assessed based on available recommendations from recognized national entities (e.g. CDC, ACIP), and clinical societies (e.g. ASH) (summarized in Table 1). Immunizations considered for analysis included: pneumococcal, meningococcal and Haemophilus influenzae vaccines ('triple vaccine' if received all together). We considered 'adherence to an immunization recommendation' when, depending on the diagnosis and treatment employed, pts received all recommended vaccines at least 2 weeks prior to therapy or 4 weeks if splenectomy. Adherence to ID screening in pts receiving RTX therapy was defined as pts screened for both hepatitis B surface antigen and total core antibodies. Influenza virus and herpes zoster (HZ) immunization rates were also analyzed. Results : 269 pts from six UNC-affiliated hospitals were included. Pts clinical characteristics are summarized in Table 2. Overall, only 6% of all evaluable pts were appropriately immunized as recommended by national guidelines (5%, 8%, and 8%, for RTX, eculizumab, and splenectomy, respectively) (Table 3). Immunization rates are summarized in Figure 1. In the eculizumab group, although 92% of HCP recommended and prescribed meningococcal immunization, only 38% (n=5/13) received both vaccines (54% either, 8% none). Likewise, although 89% (n=47/53) of pts undergoing splenectomy had received a 'triple vaccine', only 11% of pts received guideline recommended vaccines (both pneumococcal and meningococcal vaccines) and only 8% were appropriately vaccinated by receiving all indicated vaccines at least 4 weeks prior to their scheduled surgery. 68% of pts treated with RTX were appropriately screened for hepatitis B, with lower rates found in young women (screening rate: 77% age >50 vs. 58% ≤50 years, p<0.01; 83% male vs. 58% female, p<0.01) diagnosed with TTP or APS (ITP 74%, AIHA 79%, ACFD 77% vs. TTP 46%, APS 55%, p=0.01). Lastly, 36% of pts received annual influenza virus vaccine, and 11% of eligible pts the HZ vaccine. Conclusion : To the best of our knowledge, there have been no studies conducted in the U.S. assessing adherence to infectious prevention guidelines among different NMIHD. We found that in pts with NMIHD undergoing immunotherapy or splenectomy, many pts received either incomplete recommended immunizations or the immunization was administered too close in proximity to the immunosuppressive therapy or splenectomy, both resulting in impaired immunologic response to vaccines. In addition, only two thirds of pts receiving RTX had pretreatment screening for hepatitis B infection at odds with national recommendations of 100%. Lastly, low immunization rates against influenza virus and HZ were found. Based on these results, we created infographics (supplemental figure), an "easy-to-use" pocket brochure summarizing recommendations (Table 1), and we are building immunization reminders when electronically prescribing immunotherapy, with the aim of improving HCP awareness in our health care system. Although we are unsure about other institution's compliance rate, we suspect that non-compliance to immunization is a systemic problem across the U.S. We will disseminate this data hoping to replicate this study at other academic institutions. There is an urgent need for the development of strategies to improve HCP awareness and adherence to infectious prevention guidelines! Disclosures No relevant conflicts of interest to declare.

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Malpica Castillo, Luis E., Shannon Palmer, Allison Deal, Sheh-Li Chen, Anqi Zhu, and Stephan Moll. "Incidence and Time Course of Neutropenia in Patients Treated with Rituximab-Based Therapy for Non-Malignant Immune-Mediated Hematologic Diseases." Blood 134, Supplement_1 (November 13, 2019): 390. http://dx.doi.org/10.1182/blood-2019-121343.

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Background : Rituximab (RTX) is approved for various malignant hematologic and rheumatologic disorders. A noteworthy side effect, late-onset neutropenia, has been reported in patients (pts) treated for hematologic malignancies, often in combination therapies of RTX and chemotherapy with an incidence of 3% to 27%. Conversely, the lack of prospective data and the off-label use of RTX in non-malignant immune-mediated hematologic diseases (NMIHD) limits the availability of evidence on the rate, severity and time course of neutropenia on this patient population, particularly in RTX monotherapy. The present study was performed to determine the frequency, severity, and time course of development and resolution of neutropenia in NMIHD pts treated with RTX, with the goal of providing evidence for clinicians on the safety and potential implications of RTX use in this patient population. Methods : We retrospectively analyzed patients diagnosed with autoimmune hemolytic anemia (AIHA), acquired coagulation factor deficiency (ACFD), thrombotic thrombocytopenic purpura (TTP), immune thrombocytopenic purpura (ITP), and antiphospholipid syndrome (APS) between January 2013 and October 2017. Patients with a minimum of 1 laboratory visit every 8 weeks with 1-year of follow-up were included. Date of initial and last RTX infusion, RTX dosing and number of doses, and pre-treatment absolute neutrophil count (ANC) were obtained. ANCs were reviewed from first RTX infusion to at least 12 months from last infusion. For those pts who developed neutropenia, ANC nadir and date when ANC was 1 to 1.5 (mild), 0.5 to <1 (moderate), and <0.5 ˣ 103 cells/µL (severe neutropenia) was recorded. The time to recovery from neutropenia was determined from the time of first neutropenia occurrence to an ANC>1.5. Episodes of febrile neutropenia (FN), hospitalization, infection, and use of granulocyte-colony stimulating factor (GCSF) were also obtained. Kaplan-Meier estimators, and Log-rank Tests were applied to compare between groups. Results : 197 patients (ITP=94, TTP=34, AIHA=34, ACFD=22, APS=13) treated with RTX monotherapy (73%), or in combination with other immunosuppressant were included. Clinical features, treatment characteristics and outcomes are summarized in the table. The median age at diagnosis was 51 years (58% female) with a median ANC prior to RTX initiation of 5.6 ˣ 103 cells/µL. Most pts received RTX at 375 mg/m2 in 4 doses (83%). The 1-year estimated probability of developing neutropenia (ANC<1.5) was 18% (Figure 1). Of those who developed neutropenia, the median ANC nadir and time to neutropenia from initial RTX infusion was 1.2 ˣ 103 cells/µL and 4.4 months, respectively. Development of neutropenia was not statistically different by gender, age, hematologic disease type, or RTX dosing. However, RTX given for ≥ 4 doses (p=0.04), or in combination with other immunosuppressant different than steroids (p<0.01) were significantly associated. Severe neutropenia was frequent in pts receiving RTX in combination with other immunosuppressant (36% versus 2%) with longer time to recovery from first neutropenia occurrence to an ANC>1.5 (2.5 versus 1.1 months) (Figure 2) compared to pts receiving RTX alone or with steroids. No episodes of FN were reported, 3 pts were hospitalized for neutropenia workup, and 2 pts had documented infections (pneumonia and cellulitis) with uncomplicated clinical course. One pt, treated with 6-mercaptopurine, received GCSF. Conclusions : To the best of our knowledge, this is the first study reporting on the incidence, degree and time-course of development of neutropenia in patients treated with RTX for different NMIHD. Our analysis demonstrates an 18% rate of neutropenia at 1 year, mostly mild neutropenia. Conversely, RTX in combination with other immunosuppressant, as opposed to RTX alone or with steroids, represented a significant risk factor for the development of neutropenia, especially severe neutropenia with longer time to ANC recovery. The rate of hospitalizations, infections and the use of GCSF was low, even in severe neutropenia cases. In conclusion, development of neutropenia in pts treated with RTX for NMIHD is an expected but relatively benign side effect. Neutropenia is more frequent if RTX is given with other immunosuppressant other than steroids, and when the number of doses of RTX given are higher. Disclosures No relevant conflicts of interest to declare.

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Balsamo, Aldo, Bruno Macchia, Franco Macchia, Armando Rossello, and Paolo Domiano. "3-(4-iodomethyl-2-oxo-1-azetidinyl)propynoic acidt-butyl ester: a new β-lactam derivative, synthesis of an ynamide by reaction of 4-iodomethylazetidin-2-one with the t-butyl ester of propiolic acid in the presence of copper(i)." Tetrahedron Letters 26, no. 34 (January 1985): 4141–44. http://dx.doi.org/10.1016/s0040-4039(00)89314-4.

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Graf, Solomon A., Ryan C. Lynch, Chaitra S. Ujjani, Ted A. Gooley, David G. Coffey, Andrew J. Cowan, Stephen D. Smith, et al. "Oral Ixazomib in Untreated Follicular Lymphoma Permits COVID-19 Vaccine Response and Its Efficacy Is Associated with Clinical Factors and Gene Expression Signatures." Blood 138, Supplement 1 (November 5, 2021): 1363. http://dx.doi.org/10.1182/blood-2021-153168.

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Abstract Background: Standard chemoimmunotherapy for first-line treatment of follicular lymphoma (FL) achieves high rates of disease control but is not curative and carries significant toxicities including prolonged immunosuppression that may attenuate response to vaccinations (Marcus et al., NEJM 2017). While proteasome inhibitors have shown modest activity in R/R FL (Goy et al., JCO 2005), limited data address their use frontline. The comparatively favorable toxicity profile and convenient oral dosing of ixazomib support its investigation in this space. Methods: We evaluated ixazomib and its combination with short-course rituximab (R) for FL as part of an open-label, phase II investigator-initiated trial at the University of Washington / Fred Hutch Cancer Research Center / Seattle Cancer Care Alliance (NCT 02339922). Eligibility included an indication for treatment per NCCN guidelines and no prior standard systemic FL therapy. Ixazomib was administered at 4 mg orally once a week until disease progression or unmanageable toxicity. One course of R at 4 weekly doses of 375 mg/m 2 was added during the 7 th 28-day cycle, after an initial 6-cycle "window" on ixazomib alone. Available pretreatment formalin-fixed, paraffin-embedded tissue biopsies were subjected to RNA extraction by standard methods and gene expression profiling (GEP) using the NanoString™ PanCancer IO 360 panel to query pathways in proteasomal degradation and lymphomagenesis. Standard GEP quality control and data processing were performed with the ROSALIND® platform. Patients vaccinated per standard of care for COVID-19 while actively receiving ixazomib and ≥ 6 mo after completing R were evaluated for serologic response ≥ 2 weeks after the final dose of vaccine using the Roche Elecsys® Anti-SARS-CoV-2 S assay against the spike protein receptor binding domain. Results: Twenty pts began therapy between Feb 2017 and January 2020. All had grade I/II FL and FLIPI score was 2 in 20% and ≥ 3 in 20%; FLIPI score in all other patients was 0 or 1. Eleven (55%) pts met GELF criteria for high tumor burden disease including 6 (30%) pts with a tumor mass ≥ 7 cm. Median follow-up was 32.1 months (range 5.7 - 51.6). The ORR by Lugano criteria was 35% (CR 5%) during the ixazomib window and 65% (CR 45%) overall. At data cut (June 15, 2021) all patients were alive and 8 (40%) remained progression-free on treatment (Figure 1). By KM estimate, median PFS was 25.8 mo and median DOR was not reached at a median follow-up of 29.6 mo. As expected, high-grade treatment-related AEs were infrequent for ixazomib and R, including grade ≥ 3 events in 3 unique pts (15%; diarrhea, transaminitis, and cytopenias). No grade ≥ 4 or serious AEs were observed. Toxicities led to study-directed drug interruptions in 4 (20%) pts and dose reduction to ixazomib 3 mg weekly in 2 pts (10%). Higher ORR to ixazomib monotherapy was associated with FLIPI > 1 (p = 0.04) and, by exploratory GEP, downregulation of components of proteasomal degradation and upregulation of NF-KB and chemokine signaling (Figure 2). High tumor burden by GELF (p = 0.89) and tumor mass ≥ 7 cm (p = 0.26) were not associated with ORR to ixazomib. All 6 of 6 patients evaluated to date for response to COVID-19 vaccination, administered at a median of 32.5 mo (range 7.0 - 41.0) after last dose of R, achieved positive anti-spike protein antibodies (median anti-S 163.8 AU/mL, range 13.3 - 1139); none was diagnosed with COVID-19. Conclusions: The simple outpatient regimen of weekly oral ixazomib and the addition of 4 doses of R shows significant long-term activity with low toxicity in untreated FL. Extended DOR is achievable especially in patients who respond to ixazomib monotherapy. Ixazomib efficacy was associated with higher FLIPI scores and gene expression signatures implicated in proteasomal degradation and B-cell signaling pathways. Ixazomib deserves further investigation as a biomarker-driven therapeutic in untreated FL, particularly as an option that prioritizes outpatient management and serologic responsiveness to immunization. Figure 1 Figure 1. Disclosures Graf: MorphoSys: Consultancy, Research Funding; TG Therapeutics: Research Funding; AstraZeneca: Research Funding; BeiGene: Research Funding; GSK: Research Funding. Lynch: Incyte: Research Funding; SeaGen: Research Funding; TG Therapeutics: Research Funding; Cyteir: Research Funding; Genentech: Research Funding; Morphosys: Consultancy; Bayer: Research Funding; Juno Therapetics: Research Funding. Ujjani: Gilead: Honoraria; ACDT: Honoraria; Kite, a Gilead Company: Honoraria; Adaptive Biotechnologies: Research Funding; Janssen: Consultancy; TG Therapeutics: Honoraria; Loxo: Research Funding; Atara Bio: Consultancy; Epizyme: Consultancy, Membership on an entity's Board of Directors or advisory committees; AbbVie: Consultancy, Research Funding; Pharmacyclics: Consultancy, Research Funding; AstraZeneca: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding. Cowan: Bristol Myers Squibb: Research Funding; Secura Bio: Consultancy; Sanofi Aventis: Consultancy, Research Funding; Harpoon: Research Funding; Abbvie: Consultancy, Research Funding; Nektar: Research Funding; GSK: Consultancy; Cellectar: Consultancy; Janssen: Consultancy, Research Funding. Smith: Millenium/Takeda: Consultancy; ADC Therapeutics: Consultancy; KITE pharm: Consultancy; Incyte Corporation: Research Funding; Beigene: Consultancy, Research Funding; Merck Sharp & Dohme Corp: Research Funding; Portola Pharmaceuticals: Research Funding; Ignyta (spouse): Research Funding; Genentech: Research Funding; AstraZeneca: Consultancy, Research Funding; Karyopharm: Consultancy; De Novo Biopharma: Research Funding; Bristol Myers Squibb (spouse): Research Funding; Incyte: Consultancy; Acerta Pharma BV: Research Funding; Bayer: Research Funding; Ayala (spouse): Research Funding. Shadman: Mustang Bio, Celgene, Bristol Myers Squibb, Pharmacyclics, Gilead, Genentech, Abbvie, TG Therapeutics, Beigene, AstraZeneca, Sunesis, Atara Biotherapeutics, GenMab: Research Funding; Abbvie, Genentech, AstraZeneca, Sound Biologics, Pharmacyclics, Beigene, Bristol Myers Squibb, Morphosys, TG Therapeutics, Innate Pharma, Kite Pharma, Adaptive Biotechnologies, Epizyme, Eli Lilly, Adaptimmune , Mustang Bio and Atara Biotherapeutics: Consultancy. Libby: Janssen: Consultancy, Research Funding; BMS: Research Funding; Genentech: Research Funding; GSK: Research Funding. Godwin: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company; Pfizer: Research Funding. Gopal: Genetech: Consultancy, Honoraria, Research Funding; Karyopharm: Consultancy, Honoraria; Incyte: Honoraria; Acrotech: Consultancy, Honoraria; ADC Therapeutics: Consultancy, Honoraria; Kite: Consultancy, Honoraria; MorphoSys: Honoraria; Epizyme: Consultancy, Honoraria; Gilead: Consultancy, Honoraria, Research Funding; Teva: Research Funding; IGM Biosciences: Research Funding; Bristol Meyers Squibb: Research Funding; Astra-Zeneca: Research Funding; Cellectar: Consultancy, Honoraria; Agios: Research Funding; Takeda: Research Funding; Merck: Consultancy, Honoraria, Research Funding; Servier: Consultancy, Honoraria; I-Mab bio: Consultancy, Honoraria, Research Funding; Nurix Inc: Consultancy, Honoraria; Beigene: Consultancy, Honoraria; SeaGen: Consultancy, Honoraria, Research Funding; Janssen: Consultancy, Honoraria, Research Funding. OffLabel Disclosure: Ixazomib is not approved for use in follicular lymphoma.

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