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Dissertations / Theses on the topic 'Acetaminophen'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Nam, Haemi. "Acetaminophen, Aggression, and Learning: An Investigation of Acetaminophen's Social Side Effects." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557155429796022.

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2

Poon, Yuk-king Karen. "The antagonistic effect of paracetamol on ethanol-induced gastric damage in rats /." [Hong Kong] : University of Hong Kong, 1989. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12718592.

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3

Soliman, Gamal. "A study of acetaminophen analogues' toxicity." Thesis, University of Ottawa (Canada), 1985. http://hdl.handle.net/10393/4926.

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4

Reddyhoff, Dennis. "Mathematical modelling of acetaminophen induced hepatotoxicity." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/23008.

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Acetaminophen, known as paracetamol in the UK and Tylenol in the United States, is a widespread and commonly used painkiller all over the world. Taken in large enough doses, however, it can cause fatal liver damage. In the U.S., 56000 people are admitted to hospital each year due to acetaminophen overdose and its related effects, at great cost to healthcare services. In this thesis we present a number of different models of acetaminophen metabolism and toxicity. Previously, models of acetaminophen toxicity have been complex and due to this complexity, do not lend themselves well to more advanc

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5

Mischkowski, Dominik. "The Social Side Effects of Acetaminophen." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1438081282.

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6

Bashir, Shazma. "Mechanism of Paracetamol (acetaminophen) induced hypothermia." Thesis, University of East London, 2018. http://roar.uel.ac.uk/7308/.

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Paracetamol is a potent analgesic and antipyretic with limited side effects compared to the nonsteroidal anti-inflammatory drugs (NSAIDs) and opiates. Worldwide paracetamol is commonly used to treat pain and fever in both children and adults. Although, this drug has been in clinical use for more than a century, the mechanisms of action are not fully understood. Historically some of the actions of paracetamol were attributed to the inhibition of central cyclooxygenase (COX-1 and COX-2) enzymes however given the weak inhibitory effects on COX-1 and COX-2 enzymes, alternative targets have been su

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7

Xu, Zheng. "Developmental Toxicity of Dextromethorphan and Acetaminophen in Zebrafish Embryos/Larvae: Relevance of SULT-mediated Dextromethorphan/Acetaminophen Sulfation." Toledo, Ohio : University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1271433014.

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Thesis (M.S.)--University of Toledo, 2010.<br>Typescript. "Submitted to the Graduate Faculty as a partial fulfillment of the requirement for the Master of Science in Pharmacology and Toxicology." "A thesis entitled"--at head of title. Title from title page of PDF document. Bibliography: p. 68-81.

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8

Harnagea, Theophilus Eugenia. "Acetaminophen stimulates proliferation of breast cancer cells." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=773.

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Thesis (Ph. D.)--West Virginia University, 1999.<br>Title from document title page. Document formatted into pages; contains ix, 137 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 115-134).

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9

Pandey, Rajiv 1967. "Crystal size manipulation of acetaminophen via recrystallization." Thesis, The University of Arizona, 1993. http://hdl.handle.net/10150/278344.

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The crystal size distribution (CSD) of any material determines its end use. Consequently, comminution processes are used to transform material from one size distribution to another. Often, recrystallization from solution is one of the processes used. Recently, a novel recrystallization process named the GAS process was developed to mill compounds that were thermally labile and insoluble in supercritical fluids. CSD could be manipulated using this process. To further illustrate the applicability of this process, size manipulation studies of acetaminophen (a widely available drug) were performed

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10

Ito, Yoshiya, Nancy Machen, Edward Abril, and Robert McCuskey. "Effects of acetaminophen on hepatic microcirculation in mice." BioMed Central, 2004. http://hdl.handle.net/10150/610123.

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11

Mercer, Melissa Ann. "Pharmacokinetics and Safety of Acetaminophen in Adult Horses." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/85379.

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Due to the detrimental side effects of NSAID administration, such as gastrointestinal ulceration and renal papillary necrosis, there is a profound need for clinical pain relief in horses with long term orthopedic disease whereby gastrointestinal side effects are obviated. Acetaminophen is one of the most commonly used analgesic drugs in humans, and is readily available as an inexpensive generic over-the-counter preparation. Acetaminophen has a number of mechanisms of action that differ from NSAIDs, including actions on the serotonergic, opioid, endocannabinoid and lipoxygenase pathways. These

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12

Sands, Shannon, and Joel Nielsen. "Consumer Knowledge of Acetaminophen Safety, Dosing, and Identification." The University of Arizona, 2012. http://hdl.handle.net/10150/623666.

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Class of 2012 Abstract<br>Specific Aims: The objective of this study is to evaluate consumers’ knowledge about over the counter (OTC) products containing acetaminophen (APAP). Methods: Doctor of pharmacy student researchers set up a booth at consenting community pharmacies and invited consumers to participate in a 10-15 minute knowledge assessment. The booth contained a table displaying several OTC medication bottles/packages. Adult participants: a) answered baseline questions verbally about their APAP knowledge and associated risks; b) identified OTC products at the booth that contain APAP;

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13

Sands, Shannon, Joel Nielsen, and Terri Warholak. "Consumer Knowledge of Acetaminophen Safety, Dosing, and Identification." The University of Arizona, 2012. http://hdl.handle.net/10150/614521.

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Class of 2012 Abstract<br>Specific Aims: The objective of this study is to evaluate consumers’ knowledge about over the counter (OTC) products containing acetaminophen (APAP). Methods: Doctor of pharmacy student researchers set up a booth at consenting community pharmacies and invited consumers to participate in a 10-15 minute knowledge assessment. The booth contained a table displaying several OTC medication bottles/packages. Adult participants: a) answered baseline questions verbally about their APAP knowledge and associated risks; b) identified OTC products at the booth that contain AP

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14

Eakins, R. M. "The hepatic adaptive response to repeat acetaminophen exposure." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001381/.

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15

Ward, Jeanine. "MicroRNA Markers of Acetaminophen Toxicity: A Master's Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/625.

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Background To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the setting of lethal acetaminophen (APAP) toxicity in mice. Methods Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters. Results We distinguished numerous, unique plasma miRNAs both up- and down-regulated in lethally compared to sublethally dosed mice. Of note, many of the greatest up

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16

潘玉琼 and Yuk-king Karen Poon. "The antagonistic effect of paracetamol on ethanol-induced gastric damage in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31209415.

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17

Dowdy, Janet A. "Effects of acetaminophen on estrogen-responsive alkaline phosphatase in Ishikawa endometrial cancer cells." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1565.

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Thesis (M.S.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains vii, 79 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 68-79).

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18

Miao, Lei. "Synthesis of Amphibian Alkaloids and Development of Acetaminophen Analogues." ScholarWorks@UNO, 2009. http://scholarworks.uno.edu/td/985.

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The focus of these studies has been toward the development of new synthetic methods and procedures for the synthesis of novel compounds with unique biological properties. This research has led to the development of two new synthetic strategies for the construction of two novel amphibian alkaloids. In addition, the efforts have led to the large-scale process for the preparation of a novel analgesic compound. The regioselective ring opening of lactones (δ-valerolactone and γ-butyrolactone) with aryllithium reagents is reported for the construction of a series of δ-hydroxyarylketones and γ-hydrox

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19

Chowdhary, Vivek K. "Role of miR-122 in Acetaminophen Induced Liver Injury." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494133473685399.

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20

Relli-Dempsey, Vincent M. T. Relli-Dempsey. "A Thermometric Titration Study of Acetaminophen and Sodium Hypochlorite." Ohio Dominican University Honors Theses / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors152621864170557.

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21

Kim, Seol-Hee. "Acetaminophen Associated Neurotoxicity and its Relevance to Neurodevelopmental Disorders." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6717.

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Autism is a lifelong neurodevelopmental disorder. The etiology of autism still remains unclear due to the heterogeneous and complex nature of the disorder, however synergistic actions between genetic components and environmental factors have been suggested. Acetaminophen (APAP) is one of the most popular over-the-counter drugs that possess antipyretic and analgesic effects. It is considered a relatively safe and effective within therapeutic doses. Recently, early exposure to APAP has been suggested to be one of the underlying cause of autism. Children are often prescribed APAP to lessen fever

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22

Anoopkumar-Dukie, Shailendra. "Serotonin-melatonin interactions in acetaminophen and N,N-dimethylformamide toxicity." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1003957.

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Acetaminophen and N,N-dimethylformamide (DMF) are compounds which are extremely toxic to the liver. Acetaminophen is a drug which is well known for its analgesic and antipyretic properties. However, the abuse potential of this agent as a non-narcotic analgesic in alcoholics is well known. It is also the leading cause of overdose in England. DMF toxicity results mainly from occupational exposure. At present there are no known reports of an antidote for DMF poisoning, while N-acetylcysteine, the antidote for acetaminophen poisoning, is known to produce adverse effects. The present study evaluate

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23

Zhao, Ping. "The influence of alcohol on acetaminophen hepatotoxicity : CYP2E1 induction and selective mitochondrial glutathione depletion /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7952.

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24

Kühnel, Claudia [Verfasser]. "Analgesic effect of acetaminophen in neonates : systematic review / Claudia Kühnel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071088548/34.

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25

Chen, Weiqiao. "Mechanistic studies on the formation of oxidative metabolites of acetaminophen /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8162.

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26

Terneus, Marcus V. "A mechanistic study of the protective effects of S-Adenosyl-L-Methionine against hepatotoxicity of acetaminophen." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=698.

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27

Drachuk, V. M. "The nephroprotective activity of glutathione in acetaminophen-induced acute renal injury." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18899.

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28

Keaveney, Alexis A. "Acetaminophen, Affect, and Risk: An Analysis of Psychological and Neurochemical Mechanisms." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1477054183340724.

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29

Maharaj, Himant. "An investigation into the neuroprotective properties of acetylsalicylic acid and acetaminophen." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1003247.

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The potent analgesic property of acetylsalicylic acid and acetaminophen makes these the most commonly used analgesics in the world. Easy accessibility and cost effectiveness of these agents are attractive to patients seeking pain relief. However, the abuse of nonnarcotic analgesics such as acetaminophen and acetylsalicylic acid by alcoholics and patients seeking to relieve dysphoric moods is well documented. These agents therefore impact on the brain neurotransmitter levels and therefore all processes involved in the synthesis and metabolism of neurotransmitters may be affected. The use of non

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30

Manyike, Peter Tsakani. "CYP2E1 : mechanism of induction by isoniazid and role in acetaminophen oxidation /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7936.

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31

Schaer, Stephanie. "Acetaminophen as a marker of oroduodenal transit in healthy unweaned calves /." [S.l.] : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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32

Haire, Kambria. "Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5959.

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Drug toxicity may cause liver injury, resulting in damage to cells and tissues. This damage can lead to cytotoxic events that may result in an activation of poly (ADP-ribose) polymerase (PARP). A study was conducted to determine if cocaine and acetaminophen toxicity lead to DNA damage and to the activation of the repair protein, PARP in the liver using the hepatotoxicants: cocaine and acetaminophen (APAP). A dose-response analysis for cocaine concluded that a dose as low as 20 mg/kg resulted in elevated ALT levels. A higher dose of 60 mg/kg was tested for analyses but resulted in severe hemorr

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33

Bruschi, Sam A. "Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems /." Title page, abstract and table of contents only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phb192.pdf.

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34

Benitex, Yulianingsih. "The effects of phenetyl isothiocyanate and benzyl isothiocyanate on acetaminophen metabolism and toxicity in freshly isolated rat hepatocytes in cell suspension /." View abstract, 1999. http://library.ctstateu.edu/ccsu%5Ftheses/1563.html.

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Thesis (M.S.)--Central Connecticut State University, 1999.<br>Thesis advisor: Carol A. Jones. " ... in partial fulfillment of the requirements for the degree of Master of Science in Chemistry." Includes bibliographical references (leaves 42-51).

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35

McCarthy, Tara. "Comparing Robotic-Assisted and Laparoscopic Hysterectomy Conducted with and without Intravenous Acetaminophen." Kent State University Honors College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399632027.

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36

Gadd, Samantha. "Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increased c-mcy RNA expression and NF-kB activity." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2016.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains xi, 147 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 128-143).

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37

Wade, James Patrick. "Biotic and Abiotic Remediation of Acetaminophen with Woodchip and Biochar-amended Woodchip Adsorbents." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/64157.

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Pharmaceuticals and personal care products found in the environment pose a significant hazard to human and ecosystem health. While there has been significant work on the fate and remediation of pharmaceuticals and personal care products in wastewater treatment, relatively little work has explored the fate, transport and remediation of these compounds in non-point source input. This is concerning given the increasing use of pharmaceuticals in livestock production and wastewater treatment derived biosolids frequently applied to land. These experiments aimed to quantify the abiotic adsorption and

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38

Knight, Tamara, and Hartmut Jaeschke. "Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice." BioMed Central, 2004. http://hdl.handle.net/10150/610125.

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INTRODUCTION:Vascular injury and accumulation of red blood cells in the space of Disse (hemorrhage) is a characteristic feature of acetaminophen hepatotoxicity. However, the mechanism of nonparenchymal cell injury is unclear. Therefore, the objective was to investigate if either Kupffer cells or intracellular events in endothelial cells are responsible for the cell damage.RESULTS:Acetaminophen treatment (300 mg/kg) caused vascular nitrotyrosine staining within 1 h. Vascular injury (hemorrhage) occurred between 2 and 4 h. This paralleled the time course of parenchymal cell injury as shown by th

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39

Wells, Larry Kevin. "Efficacy of Ibuprofen and Ibuprofen/Acetaminophen on Postoperative Pain in Symptomatic Necrotic Teeth." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1283354429.

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40

Balzer, Stephen. "IBUPROFEN/ACETAMINOPHEN VERSUS SPRIX IN TEETH DIAGNOSED WITH PULPAL NECROSIS AND SYMPTOMATIC APICAL PERIODONTITIS." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu153191176802337.

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41

Nicholls-Grzemski, Felicity April. "The effect of short-term pretreatment with peroxisome proliferators on the acute toxicity of various toxicants, including paracetamol /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phn6158.pdf.

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42

Paterson, Andrea Beth. "Mechanisms of acetaminophen-induced hepatotoxicity, effects of mitochondrial glutathione, protein thiols and oxidative phosphorylation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22375.pdf.

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43

Wu, Meng-Jie, and 吳孟潔. "Electo-oxidation of Acetaminophen." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/25760232195482962113.

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碩士<br>國立屏東科技大學<br>環境工程與科學系所<br>99<br>This study investigated degradation of acetaminophen (ACP) in water using electrochemical oxidation. The experimental results showed that the degradation rate of ACP on tested anodes was in order Pt > platinized > DSA. Increasing electrode area or temperature increased ACP degradation . The electrochemical degradation of ACP was better using an 1 M sodium sulfate solution as the electrolyte than using 1 M H2SO4. Cyclic voltammetry (CV) analysis showed that the higher the pH, the lower the potential required for ACP oxidation; moreover, in phosphate buffer s

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44

Pan, Yi-Chuan, and 潘一全. "Oxidative Degradation of Acetaminophen." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/34585471035980533713.

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碩士<br>國立屏東科技大學<br>環境工程與科學系所<br>100<br>The Contents of Abstract in This Thesis: In this study, electro-regeneration of Ce(IV) from Ce(III) in prepared and spent Cr-ehtching solutions used in TFT-LCD manufacturing processes was performed. The regenerated Ce(IV) was used in a Ce(IV)-mediated electrochemical oxidation (MEO) process which was then compared with direct electro-oxidation for the degradation of acetaminophen. The results showed that the magnitude of acetaminophen degradation rate on tested anodes was in order PbO2/Sn2O3SnO2/Ti > Pt > BDD, while that in the electrolytic cell using diff

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45

Hossain, Mohammad. "Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation." Thesis, 1991. http://hdl.handle.net/1957/37368.

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Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate animal model for studying bioavailability or GI transit of non-disintegrating, non-erodible oral release dosage forms. Development of controlled release dosage forms where the mechanism of drug release is diffusion through polymeric membrane formed via film coating utilizing f

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46

HUANG, DONG-YU, and 黃東裕. "Studies on the nitrosation reaction of acetaminophen." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/70417958503494794207.

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47

Youssefi, Mohammed. "The Effect of acetaminophen on isoniazid metabolism." Thesis, 1992. http://hdl.handle.net/2429/2350.

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Acetaminophen (APAP, paracetamol, N-acetyl-p-aminophenol), an analgesic and antipyretic drug, causes liver necrosis in overdose. Isoniazid (INH, isonicotinyl hydrazide), an antituberculous drug, also causes liver damage in some patients at therapeutic doses. The two medications are likely to be taken concurrently. Previously we reported that, depending on the condition, INH inhibits or induces the toxic pathway of APAP metabolism. In this study the influence of APAP on INH metabolism was investigated in ten healthy volunteers. INH, 300 mg, was ingested daily for 7 days. APAP, 500 mg, was inges

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48

Wang, Ching-Tsung, and 王慶宗. "A Study on Acetaminophen Taste Masked Preparation." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89246161831696405260.

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碩士<br>高雄醫學大學<br>藥學研究所碩士在職專班<br>99<br>Acetaminophen is commonly used as antipyretic. However, its bitter taste hastened it used. In order to decrease the bitter taste of acetaminophen and increase the compliance of patient, spray drying process is used to find out the optimal bitter taste masking formulation and procedure. The formulation contained 90% of Acetaminophen, 6.85 to 8.65% of Starch, 0.15% of Stearic acid, and 1.2 to 3.0% of PVP K-30. Starch and PVP K-30 accounted for 9.85%. The percentage of starch decreased as the portion of PVP K-30 increased. Spray drying was used to optimize pro

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49

Chang, An-Tzu, and 張安慈. "Degradation of Acetaminophen by Different Fenton Processes." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/91023766163948422044.

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碩士<br>嘉南藥理科技大學<br>環境工程與科學系暨研究所<br>99<br>A new approach for increasing ferric reduction efficiency using different electro-Fenton and photoelectro-Fenton processes has been developed to degrade organic toxic contaminants. Over the past decade, human and veterinary Pharmaceuticals and Personal Care Products (PPCPs) have received increasing attention as POPs in waters. These emerging pollutants are continuously introduced into the aquatic environment at ng-μg L-1 levels by several routes including emission from production sites, direct disposal of overplus drugs in households and hospitals, excre

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50

Keller, Carol Ann. "Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients." Thesis, 2000. http://hdl.handle.net/1957/33246.

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Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5��g/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses and input rates for sustained release formulations of acetaminophen. Once parameters were selected from the simulations, sample formulations were prepared and tested using standard dissolution techniques. Investigations into dose/size relationships, hydroxyp

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