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1

Hankin, Lester. Analysis of products containing acetaminophen. New Haven, Conn: Connecticut Agricultural Experiment Station, 1986.

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2

Weglicki, Peter S. Free radical reactions of acetaminophen. Salford: University of Salford, 1987.

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3

Hankin, Lester. Analysis of products containing acetaminophen. New Haven, Conn: Connecticut Agricultural Experiment Station, 1986.

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4

Paracetamol (acetaminophen): A critical bibliographic review. 2nd ed. London: Taylor & Francis, 2001.

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5

Paracetamol (acetaminophen): A critical bibliographic review. London, UK: Taylor & Francis, 1996.

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6

Folkenberg, Judy. Acetaminophen-codeine: How to take your medicine. [Rockville, Md: Dept. of Health and Human Services, Food and Drug Administratrion, 1991.

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7

Folkenberg, Judy. Acetaminophen-codeine: How to take your medicine. [Rockville, Md: Dept. of Health and Human Services, Food and Drug Administratrion, 1991.

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8

Folkenberg, Judy. Acetaminophen-codeine: How to take your medicine. [Rockville, Md: Dept. of Health and Human Services, Food and Drug Administratrion, 1991.

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9

Folkenberg, Judy. Acetaminophen-codeine: How to take your medicine. [Rockville, Md: Dept. of Health and Human Services, Food and Drug Administratrion, 1991.

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10

Lin, Meng-Chih. Post-consolidation behaviour of acetaminophen crystals. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1993.

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11

National Register of Foreign Collaborations (India) and India. Dept. of Scientific & Industrial Research., eds. Technology in Indian paracetamol industry: A status report prepared under the National Register of Foreign Collaborations. New Delhi: Govt. of India, Dept. of Scientific & Industrial Research, Ministry of Science and Technology, 1994.

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12

Foisy, Michelle M. An Overview of Acetaminophen overdoses at the Ottawa General Hospital. [Ottawa: s.n., 1989.

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13

J, Meredith T., World Health Organization, Commission of the European Communities., and International Program on Chemical Safety., eds. Antidotes for poisoning by paracetamol. Cambridge: Published by Cambridge University Press on behalf of the World Health Organization and of the European Commission, 1995.

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14

Parker, James N., and Philip M. Parker. Acetaminophen: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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15

Parker, Philip M., and James N. Parker. Tylenol: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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16

Midroni, Ran. The effect of acetylsalicylic acid and acetaminophen on edema, adrenocorticotropin and beta-endorphin during orofacial inflammation. [Toronto: University of Toronto, Faculty of Dentistry], 1996.

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17

Lau, Grace S. N. Metabolic activation of drugs and other xenobiotics in hepatocellular carcinoma. Hong Kong: Chinese University Press, 1997.

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18

Baker, Brennan H. Prenatal acetaminophen exposure as a risk factor for Attention Deficit Hyperactivity Disorder (ADHD): Underlying mechanisms in humans and mice. [New York, N.Y.?]: [publisher not identified], 2022.

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19

Kwan, Debora. The effects of acute and chronic acetaminophen dosing on the pharmacodynamics and pharmacokinetics of the (R)- and (S)- enantiomers of warfarin. Ottawa: National Library of Canada, 1993.

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20

George, Doctor Lawrence. Acetaminophen:. Independently Published, 2019.

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21

Parker, Philip M. The 2007-2012 World Outlook for Acetaminophen and Acetaminophen Combinations. ICON Group International, Inc., 2006.

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22

The 2006-2011 World Outlook for Acetaminophen and Acetaminophen Combinations. Icon Group International, Inc., 2005.

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23

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen and Acetaminophen Combinations in Japan. ICON Group International, Inc., 2006.

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24

Beaulieu, Pierre. Mechanisms of action of acetaminophen for pain treatment. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0046.

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The landmark paper discussed in the chapter, published by 2008 by Mallet et al., reports on the mechanisms of action of acetaminophen for pain treatment. Acetaminophen, also known as paracetamol (N-acetyl-para-aminophenol), has analgesic and antipyretic properties and has superior tolerance, compared to non-steroidal anti-inflammatory drugs, making it appropriate for widespread use in patients. However, despite many years of use worldwide and numerous studies, acetaminophen’s mechanism of action is still uncertain. The article by Mallet et al. is a landmark paper because it reconciled many observations made at the time to propose a plausible mechanism of action of acetaminophen in pain treatment.
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25

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen and Acetaminophen Combinations in Greater China. ICON Group International, Inc., 2006.

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26

Javaherian, Atash, and Pasha Latifpour. Acetaminophen: Properties, Clinical Uses and Adverse Effects. Nova Science Publishers, Incorporated, 2012.

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27

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen and Acetaminophen Combinations in the United States. ICON Group International, Inc., 2006.

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28

Levine, Michael. Management of acetaminophen (paracetamol) poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0318.

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Acetaminophen overdose remains common, and is one of the most frequent reasons for liver transplant in the United States. Toxicity results from the metabolism to a toxic metabolite, N-acetyl-para-benzoquinoneimine. This chapter begins with a brief discussion of the history and epidemiology of acetaminophen overdose, followed by a discussion on the pharmacokinetics and pharmacodynamics. The risk factors, clinical presentation, and treatment strategies presented.
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29

Institute, American Health Research. Acetaminophen: Index of New Information. Abbe Pub Assn of Washington Dc, 1994.

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30

Institute, American Health Research. Acetaminophen: Index of New Information. Abbe Pub Assn of Washington Dc, 1994.

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31

Kong, Rowena. Of Caffeine, Acetaminophen and Immunomodulator Adenosine. Independently Published, 2020.

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32

Lin, Meng-Chih. Post-consolidation behaviour of acetaminophen crystals. 1992.

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33

Mansell, Libbie J. New acetaminophen products: Formulation development and bioavailability. 1990.

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34

Borin, Marie T. New product formulations and pharmacokinetics of acetaminophen. 1985.

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35

Group, Research, and The Acetaminophen Research Group. The 2000-2005 World Outlook for Acetaminophen (paracetamol). 2nd ed. Icon Group International, 2000.

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36

Schultz, Dr Stephen. The Cause of Autism: Vaccines, Acetaminophen, and Inflammation. Independently Published, 2019.

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37

Parker, Philip M. The 2007-2012 World Outlook for Acetaminophen (paracetamol). ICON Group International, Inc., 2006.

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38

Bishākta sirāpa: Bhejāla pyārāsiṭāmala kāhinī. Ḍhākā: Bāṃlādeśa Seṇṭāra phara Ayāḍabhānsaḍ Sṭāḍija, 1994.

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39

Sahajwalla, Chandrahas G. New product formulation and multiple dose pharmacokinetics of acetaminophen. 1987.

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40

Hossain, Mohammad. Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation. 1991.

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41

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Oceana. Icon Group International, 2001.

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42

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Europe. Icon Group International, 2001.

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43

Jolly, Karen H. Acetaminophen: A Proven Solution for the Treatment of Concussion. Independently Published, 2019.

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44

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in India. ICON Group International, Inc., 2006.

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45

Inc, ICON Group International. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Africa. Icon Group International, 2001.

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46

Inc, ICON Group International. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Asia. Icon Group International, 2001.

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47

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in Japan. ICON Group International, Inc., 2006.

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48

Inc, ICON Group International. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Latin America. Icon Group International, 2001.

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49

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in Greater China. ICON Group International, Inc., 2006.

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50

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in the Middle East. Icon Group International, 2001.

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