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Dissertations / Theses on the topic 'ABT'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 January 2023

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1

Schachenmayr, Alkuin Volker. "Abt Karl Braunstorfer (1895 - 1978) Abt von Heiligenkreuz und Abtpräses der Österreichischen Cistercienserkongregation." Berlin Lukas-Verl, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2673820&prov=M&dok_var=1&dok_ext=htm.

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2

Veit, Joachim. "Abt Voglers ”Verbesserungen” Bachscher Choräle." Bärenreiter Verlag, 1987. https://slub.qucosa.de/id/qucosa%3A37257.

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3

Kohnle, Armin. "Abt Hugo von Cluny (1049 - 1109) /." Sigmaringen : J. Thorbecke, 1993. http://catalogue.bnf.fr/ark:/12148/cb355878594.

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4

Abt, Andreas [Verfasser], and Kristian [Akademischer Betreuer] Kunert. "Die Balance der Verantwortung / Andreas Abt ; Betreuer: Kristian Kunert." Tübingen : Universitätsbibliothek Tübingen, 2006. http://d-nb.info/1162136340/34.

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5

Levesley, Jane. "RASSF1A and ABT-737 promote apoptosis in medulloblastoma cell lines." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555734.

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Medulloblastoma is the most commonly occurring malignant brain tumour of childhood. The RASSF1A tumour suppressor is potentially the most important candidate gene identified in medulloblastoma to date, being epigenetically silenced in over 79% of primary tumours. In other tumour types, RASSF1A has been shown to play key roles in both cell cycle regulation and apoptotic signalling pathways. However, its functional role has not been previously addressed in medulloblastoma. UW228-3 medulloblastoma cells, stably expressing RASSF1A displayed increased sensitivity to an anti-CD95 antibody and to the chemotherapeutic agents, etoposide, cisplatin or vincristine, compared to vector control cells. In RASSF1A-expressing UW228-3 cells, increased cleavage of key caspases and of the DNA repair protein, PARP was observed following treatment with anti-CD95 or etoposide in comparison to vector control cells. In addition, inhibition of caspases in RASSF1A-expressing UW228-3 cells by Z-VAD-FMK, prevented apoptotic DNA fragmentation following death receptor activation (by anti-CD95) or DNA damage (induced by etoposide). Increased phosphorylation of H2AX was also observed in RASSF1A-expressing UW228-3 cells during apoptosis, suggesting a possible novel function for this tumour suppressor in the regUlation of histone modification during apoptotic cell death. Increased activation of the pro-apoptotic BCL-2 family member, BAX was also observed in UW228-3 cells stably expressing RASSF1A following activation of both the extrinsic and intrinsic apoptotic pathways. Further investigation of BAX activation in UW228-3 cells revealed that apoptotic signalling can also be promoted in the absence of RASSF1A using the BH3-only mimetic, ABT-737 (BAD-mimetic) in combination with chemotherapeutic agents (etoposide, cisplatin and vincristine). ABT- 737 increased susceptibility to apoptosis induced by DNA damage regardless of RASSF1A expression status through increased activation of BAX. In conclusion, data from this study shows that RASSF1A has a proapoptotic function in vitro and may potentially modulate therapeutic response via the BCL-2 family (and BAX in particular). This family of proteins therefore represent tractable therapeutic targets in medulloblastoma.

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6

Abt, Felix [Verfasser], and Thomas [Akademischer Betreuer] Graf. "Bildbasierte Charakterisierung und Regelung von Laserschweißprozessen / Felix Abt ; Betreuer: Thomas Graf." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2017. http://d-nb.info/115340365X/34.

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7

Abt, Bärbel [Verfasser]. "Chemical and structural analysis of Xylella fastidiosa biofilm formation / Bärbel Abt." Ulm : Universität Ulm, 2018. http://d-nb.info/115485633X/34.

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8

Walther, Gerrit. "Abt Balthasars Mission : politische Mentalitäten, Gegenreformation und eine Adelsverschwörung im Hochstift Fulda /." Göttingen : Vandenhoeck & Ruprecht, 2002. http://catalogue.bnf.fr/ark:/12148/cb38899804g.

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9

Groth, Carsten [Verfasser]. "Hanse und Recht. : Eine Forschungsgeschichte. (Abt. B: Abhandlungen zur Deutschen Rechtsgeschichte). / Carsten Groth." Berlin : Duncker & Humblot, 2016. http://d-nb.info/1238438695/34.

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10

Krzysteczko, Patryk [Verfasser]. "Memristive tunnel junctions / Patryk Krzysteczko. Fakultät für Physik. Abt. Experimentalphysik : Dünne Schichten und Nanostrukturen." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2010. http://d-nb.info/1011764563/34.

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11

Micha, Dimitra. "Pre-clinical evaluation of Bcl-2 inhibitor ABT-737 in small cell lung cancer." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506239.

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The evasion of apoptosis is a common feature of various malignancies and often depends on the overexpression of Bcl-2 family antiapoptotic proteins. Resistance to chemotherapy and radiotherapy is promoted because these tumour cells have a higher threshold for apoptosis-promoting signals than their normal cell counterparts. This has lead to the development of BH3 mimetic compounds that target the survival proteins of the Bcl-2 family.

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12

Timm, Alexander [Verfasser]. "Der Entwurf eines Strafgesetzbuches von 1962. : (Abt. B: Abhandlungen zur Deutschen Rechtsgeschichte). / Alexander Timm." Berlin : Duncker & Humblot, 2016. http://d-nb.info/1238439411/34.

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13

Stuke, Maik [Verfasser]. "The first second of leptons / Maik Stuke. Abt. Theoretische Physik : Theoretische Hochenergiephysik -- Fakultät für Physik." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1013298063/34.

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14

Svensson, Adam, and Anders Hoffman. "Allocation of Risks in PPP Projects : A Comparison of UK Standard Form and Swedish ABT 06." Thesis, Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-15319.

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15

Falk, Rasmus. "Kommunikation och avtalsadministration : För ökad förståelse mellan parter vid använding av AB 04 och ABT 06." Thesis, Uppsala universitet, Byggteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-257706.

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The construction industry is constantly evolving with new products and building technical solutions. The construction industry organization jointly developed regulations known as standard contracts, or general regulations, which includes ten chapters. The standard contracts describe what the constructor industry should relate to in terms of performance and responsibility. When the standard contracts were negotiated about between the various parties in the industry some sections were developed through compromises. It is mainly in these sections misunderstandings, interpretations differences and conflicts occur. This report investigates in which sections conflicts commonly occur, what the consequences are and how the generally perception of the standard contracts is in the industry. The report also suggests solutions and improvements to the standard contracts. Eleven basic questions based on the generally perceptions of the standard contracts and the first six chapters of the standard contracts have been developed to clarify where disputes and misunderstandings may occur. The remaining four chapters have been deliberately excluded to limit the scope of this report. The content of the report is mainly based of twenty interviews with contractors and clients. The study shows that the perception of the standard contracts is positive and serves as a good tool to know what to relate to. The standard contracts should however adapt more to today's technological society. The study also presents suggestions on methods and advices that can be used to facilitate communication in the construction industry. This thesis in the Bachelor of Science in Construction Engineering at Uppsala University has carried out for ten weeks at a property company Klövern in Kista.
Byggbranschen utvecklas ständigt med nya produkter och byggtekniska lösningar vilket gör att uppförandet och förhållningssättet ändras med tiden. Branschorganisationen har gemensamt framtagit föreskrifter som benämns standardavtalen eller Allmänna bestämmelser som innefattar tio kapitel. I standardavtalen förklaras vad parterna ska förhålla sig till exempelvis vad gäller utförandet och vilket ansvar de har rent juridiskt. Det här för att undvika att parter hamnar i tvist med varandra. Man kan se standardavtalen som spelregler för byggbranschen som då vet vad man ska förhålla sig till. Då standardavtalen har förhandlats fram mellan de olika parterna i branschen innehåller de en del paragrafer som har tagits fram genom kompromisser och det är främst här missförstånd, oliktolkningar och konflikter uppstår. Den här rapporten undersöker vilka frågor som leder till att tvister vanligast uppkommer, i viss mån vad konsekvenserna blir och vidare undersöks hur synen på standardavtalen överlag ser ut i branschen. Rapporten leder fram till förslag hur standardavtalen överlag kan förbättras. Arbetet baseras på elva grundfrågeställningar kring den allmänna uppfattningen av standardavtalen samt ett antal frågor rörande bestämmelser i de sex första kapitlen i standardavtalen. Dessa har tagits fram för att klargöra vart tvister och missförstånd kan tänkas uppkomma. De resterande fyra kapitlen har medvetet uteslutits för att begränsa omfattningen i den här rapporten. Innehållet i rapporten grundar sig främst i ett tjugotal intervjuer som har genomförts med entreprenörer och beställare. Undersökningen visar att synen på standardavtalen är positiv och fungerar som ett bra verktyg för att veta vad man ska förhålla sig till. Standardavtalen bör dock anpassas till dagens tekniska samhälle. Det redovisas även förslag på metoder och råd som kan användas för att underlätta kommunikationen mellan parterna. Detta examensarbete inom högskoleingenjörsprogrammet i byggteknik på Uppsala universitet har utförts under tio veckor åt fastighetsbolaget Klövern i Kista.

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16

Abt, Eva Christine [Verfasser]. "Aussagekraft einer systematischen Zervixkürettage in der Nachsorge nach primärer Radiochemotherapie beim fortgeschrittenen Zervixkarzinom / Eva Christine Abt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1082536806/34.

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17

Kim, Sung Woo. "Combining Noxa-Inducing Drugs with ABT-263 to Efficiently Increase Cell Death in Head and Neck Squamous Cell Carcinoma (HNSCC)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4847.

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Head and neck cancer is the sixth leading cancer worldwide. Head and neck squamous cell carcinoma (HNSCC) accounts for more than 90% of incident cases. Despite intense, multimodality treatment regimens for HNSCC including surgery, chemotherapy, and radiation, little progress has been made over the past 30 years in improving overall survival rates. Tumor cell death induced by both conventional and targeted chemotherapy is often mediated by the BCL-2 family-dependent mitochondrial apoptotic pathway. However, initiators of this apoptotic pathway, such as p53, are more than 50% of the time mutated or deleted in HNSCC rendering the disease refractory to treatment. To counter such resistance, direct therapeutic targeting of the BCL-2 family is conceptually appealing. For this purpose, we use three clinically-available drugs: cisplatin, fenretinide, and ABT-263 (navitoclax). Both cisplatin and fenretinide are known to induce a BH3-only pro-apoptotic protein, Noxa, which binds to and inactivates multi-domain anti-apoptotic protein MCL-1 and release from its interaction with multi-domain pro-apoptotic protein BAK, followed by the phosphorylation via CDK2 for the proteasome-mediated degradation. Activated BAK can now go through conformational change for the oligomerization at the outer membrane of the mitochondria to release cytochrome c into the cytosol and induce caspase-dependent apoptotic cell death. ABT-263 directly binds to multi-domain anti-apoptotic proteins, such as BCL-2 and BCL-XL, to inhibit their activity and leads to the activation of multi-domain pro-apoptotic protein BAX to induce apoptosis. We hypothesize that combining the Noxa-inducing drugs (cisplatin or fenretinide) along with ABT-263 can efficiently induce BAX and BAK activation and significantly increase cell death in HNSCC cells by simultaneously inhibiting the activity of MCL-1, BCL-2, and BCL-XL. Combination-induced treatments in four cell lines (HN8, HN30, HN31, and UMSCC1) tested led to significant increase in apoptotic cell death. Cisplatin and ABT-263 combined treatment is inducing the expression of Noxa and leading to increase in apoptosis in HN30, HN31, UMSCC1, but not HN8. Similarly, fenretinide and ABT-263 combined treatment is inducing the expression of Noxa in all four cell lines tested and is largely relying on expression of Noxa.

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18

Schebaum, Oliver [Verfasser]. "Bestimmung der Spinpolarisation durch supraleitende Tunnelspektroskopie / Oliver Schebaum. Abt. Experimentalphysik : Dünne Schichten und Nanostrukturen -- Fakultät für Physik." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/101370679X/34.

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19

Radcliffe, Jeanette, and n/a. "The Australian Broadcasting Tribunal's Australian Content Inquiry 1983 - 1990: a case study in The dynamics of a public policy debate." University of Canberra. Communication, Media & Tourism, 1994. http://erl.canberra.edu.au./public/adt-AUC20061207.162525.

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Since their inception in the early 1960s, Australian content requirements for commercial television have been subjected to considerable scrutiny through a series of formal inquiries. Over the last ten years this process has intensified. In recent years there have been a number of academic criticisms regarding the state of debate about the regulation of Australian content on commercial television and the capacity of the debate to generate genuine criticism and embrace change. This thesis examines the dynamics of debate about Australian content. It focuses on the ABT's Inquiry into Australian Content on Commercial Television (ACI) which ran from 1983 to 1989. It takes as its basic point of reference Jurgen Habermas' concept of the 'public sphere'. This concept refers to a realm of social life, separate from the state and private spheres, in which 'public opinion' can be formed. Habermas has argued that, with the refeudalisation of the public sphere, the state and private interests have increasingly collaborated to close off the public sphere. The thesis concludes that in many respects Habermas' concept of a refeudalised 'public sphere' is a useful explanatory tool for understanding the dynamics of the ACI and the limited degree of criticism generated by it. However, Habermas' model is limited in so far as it fails to accord adequate recognition to the complexities and significance of the mediation of the 'public interest' by key participants in the inquiry and the strategic role of rhetoric for these participants. Habermas concludes that with the refeudalisation of the public sphere and the disappearance of the historical conditions which supported its operation, the public sphere must now be reconstructed on a case by case basis. Attempts to achieve this, have tended to focus on the facilitation of citizen participation in public policy debate. However, as this analysis of the ACI demonstrates, the dynamics of the debate itself appear to limit I the degree to which 'public opinion' can be elevated above 'private interest'. This thesis demonstrates that the mediation of the 'public interest' assumed a central role in the rhetoric and strategy of the ACI. Each of the key players represented distinct interests and were largely unaccountable to the 'public' they claimed to serve. This thesis concludes that in order to gain a more detailed understanding of how communication works in such a context, and in order to conceive of alternative participatory forms, we need to focus on those aspects of public discourse which Habermas neglects: the rhetoric and the strategic nature of public representation. It suggests that fruitful avenues for further study may lie with Bantz's notion of communicative structures or Luhmann's systems approach to communication.

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20

Karlsson, Sonny, and Markus Olsson. "Kartläggning av eftermarknadsärenden : En analys av felanmälningar under garantitiden." Thesis, Uppsala universitet, Industriell teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298650.

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This thesis has been conducted in collaboration with JM AB, Region Öst, based at their office in Uppsala. Below follows a summary of the study. Problem For the major contractors in Sweden, the costs after the costumers access are high. According to Boverket the costs can be as high as 1.3 billion SEK annually. In addition of the costs of the work itself, the companies risks dissatisfied customers when the extra work often is considered as a disturbance. To investigate this matter, the purpose of this thesis is to answer the following questions: - What are the most common errors reported during the warranty period? - Can the errors be addressed at an earlier stage? - Is poor purchasing a contributing factor to the high costs during the warranty period? - Can a different ventilation system reduce the amount of errors? Method The purpose of the study is to identify the most common errors that occur during the warranty period, to summarize these and give concrete suggestions of measures to reduce the errors. The report is based on interviews, statistics of the errors from JM Region Öst during year 2015 and the analysis of the customers feedback during the warranty period of eight projects. In addition, the authors have chosen to compare two different ventilations systems to see if the change of system can reduce the number of error reports concerning ventilation. Conclusions The study shows an even distribution of errors from the different categories. The reports from JM Region Öst during year 2015 and the average from the selected projects have similar distribution. Of the total number of error reports from JM Region Öst during year 2015, 20.1 percent belonged to the category Plumbing. The same category had, in the authors compilation of the eight projects, 20.2 percent of the reports. From this result it can be concluded that the percentage of problems reported from each category is about the same, no matter the size of the project. In the interviews, the most common errors and what causes these, were discussed. Because of the many errors to the category Plumbing, this was the main subject. During the interviews it was discovered that different actors blames the problems on each other. However, dirt in the pipe system in combination with a low water pressure was considered to be the biggest cause of problems to the category. The study also shows that a complicated list of responsibilities generates costs for the after-sales department. The reason is that the process of appointing a responsible actor becomes hard. The consequence of this is that staff from the after-sales department is forced to make visits to the projects only to be able to redirect the matter to the responsible subcontractor.

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21

Britt, Erin L. "Targeting BCL-2 Family Members in the Cell Death Pathway to Treat Head and Neck Cancer." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5352.

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Head and neck cancer accounts for approximately 3 percent of all cancers in the United States, and over 90% of them are head and neck squamous cell carcinoma (HNSCC). Chemotherapeutic drugs that treat HNSCC can activate BCL-2 family dependent apoptosis. Pro-apoptotic NOXA induced by adenovirus (Ad-NOXA) or fenretinide inactivates anti-apoptotic MCL-1, while ABT-263 can inactivate other anti-apoptotic BCL-2 family members such as BCL-2 and BCL-XL. We used p53 inactive HN8 and HN12, p53 wild-type UMSCC1, and HPV-positive UMSCC47 human HNSCC cell lines and five mouse HNSCC cell lines. Cells were treated with Ad-NOXA, ABT-263, and fenretinide alone or in combinations. Combinational treatment of ABT-263 with Ad-NOXA or fenretinide enhanced cell death among all cell lines we tested regardless of p53 status. These findings support the hypothesis that combinational treatment of Ad-NOXA or fenretinide with ABT-263 increases cell death by simultaneously inhibiting all anti-apoptotic BCL-2 family proteins in HNSCC cells.

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22

Winkler, Markus [Verfasser]. "Mathematik und Logik in Julians Digesten. : (Abt. A: Abhandlungen zum Römischen Recht und zur Antiken Rechtsgeschichte). / Markus Winkler." Berlin : Duncker & Humblot, 2015. http://d-nb.info/1238436056/34.

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23

Ebke, Daniel [Verfasser]. "Cobalt-based Heusler compounds in magnetic tunnel junctions / Daniel Ebke. Fakultät für Physik - Abt. Experimentalphysik : Dünne Schichten und Nanostrukturen." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1015182399/34.

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Seefeldt, Britta [Verfasser]. "Entwicklung und Charakterisierung neuartiger Fluoreszenzsonden für fortgeschrittene Mikroskopiemethoden / Britta Seefeldt. Fakultät für Physik. Abt. Experimentalphysik : Angewandte Laserphysik und Laserspektroskopie." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1010917455/34.

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25

Hörl, Rebecca Louise [Verfasser]. "Efficacy and molecular mechanisms of the BH3-mimetic venetoclax (ABT-199) in pediatric acute lymphoblastic leukemia / Rebecca Louise Hörl." Ulm : Universität Ulm, 2020. http://d-nb.info/1208767089/34.

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Gröndahl, Alexander, and Gustav Wernersson. "Projektering av markarbete, parkeringsplatser, cykelställ m.m." Thesis, Linnéuniversitetet, Institutionen för byggteknik (BY), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-35552.

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Arbetet tar upp lösningsförslag och val av lösning för en unik parkeringsplats på ett företag i Emmaboda. Lösningarna omfattar lokalt omhändertagande av dagvatten, val av beläggningstyper och trafiksäkerhet. Arbetet kommer att användas av Xylem till förfrågningsunderlaget för kommande anläggning av parkeringen.

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27

Schnietz, Mark [Verfasser]. "Herstellung von Biochips basierend auf selbstaggregierender Monolagen / Mark Schnietz. Abt. Experimentalphysik : Physik supramolekularer Systeme, Atome und Cluster -- Fakultät für Physik." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1013357140/34.

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Hasenritter, Mona [Verfasser]. "Wilhelm Theodor Kraut (1800–1873). : Ein Leben für die Lehre. (Abt. B: Abhandlungen zur Europäischen und Deutschen Rechtsgeschichte). / Mona Hasenritter." Berlin : Duncker & Humblot, 2018. http://d-nb.info/1238440975/34.

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Gunkel, Manuel [Verfasser]. "Lokalisationsmikroskopie mit mehreren Farben und ihre Anwendung in biologischen Präparaten / Manuel Gunkel. Abt. Experimentalphysik : Angewandte Laserphysik und Laserspektroskopie -- Fakultät für Physik." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1013969480/34.

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30

Zhang, Xianghui [Verfasser]. "Mechanical characterization of carbon nanosheets / Xianghui Zhang. Fakultät für Physik. Abt. Experimentalphysik : Physik supramolekularer Systeme, Atome und Cluster -- Fakultät für Physik." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1010819356/34.

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Abt, Raimond [Verfasser], Johanna Karen [Gutachter] Erdmenger, Thorsten [Gutachter] Ohl, and Robert Graham [Gutachter] Leigh. "Implementing Aspects of Quantum Information into the AdS/CFT Correspondence / Raimond Abt ; Gutachter: Johanna Karen Erdmenger, Thorsten Ohl, Robert Graham Leigh." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1196533342/34.

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32

Blume, Dieter. "Bern von Reichenau (1008 - 1048) Abt, Gelehrter, Biograph ; ein Lebensbild mit Werkverzeichnis sowie Edition und Übersetzung von Berns Vita S. Uodalrici." Ostfildern Thorbecke, 2004. http://d-nb.info/988788063/04.

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33

Abt, Alexander [Verfasser], Urs [Gutachter] Müller-Richter, and Ulrich [Gutachter] Schlagenhauf. "Einfluss von HGF und Foretinib auf den Glukosestoffwechsel bei Zelllinien des oralen Plattenepithelkarzinoms / Alexander Abt ; Gutachter: Urs Müller-Richter, Ulrich Schlagenhauf." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1213659760/34.

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34

Speer, David [Verfasser]. "Spontaneous symmetry breaking transport : from anomalous response to chiral separation / David Speer. Fakultät für Physik. Abt. Theoretische Physik : Theorie der Kondensierten Materie." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1011897105/34.

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35

Gokel, Julia Maria [Verfasser]. "Sprachliche Indizien für inneres System bei Q. Cervidius Scaevola. : (Abt. A: Abhandlungen zum Römischen Recht und zur Antiken Rechtsgeschichte). / Julia Maria Gokel." Berlin : Duncker & Humblot, 2014. http://d-nb.info/1238430368/34.

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36

Laseur, Christine [Verfasser], and Karsten [Akademischer Betreuer] Spiekermann. "BH3-Mimetikum ABT-737 neutralisiert Resistenz durch Überexpression von BCL2 bei FLT3 PTK-Inhibitor-Behandlung in AML-Blasten / Christine Laseur. Betreuer: Karsten Spiekermann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1084582562/34.

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37

Domisch, Jörg [Verfasser]. "Zur Frage eines Besitzübergangs auf den Erben im klassischen römischen Recht. : (Abt. A: Abhandlungen zum Römischen Recht und zur Antiken Rechtsgeschichte). / Jörg Domisch." Berlin : Duncker & Humblot, 2014. http://d-nb.info/1238434959/34.

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Choudhary, Gaurav Sudhakar. "Role of Myeloid Cell Leukemia 1 (MCL-1) in mediating chemoresistance towards BCL-2 homology 3 (BH3) mimetics in lymphoid malignancies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448024862.

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39

Winqvist, Ebba. "Ansvarsfördelning i byggsektorns avtal AB 04 vid skada som träffar tredje man." Thesis, Linköpings universitet, Affärsrätt, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93227.

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Byggavtalet AB 04 återfinns inom entreprenadrättens område, ett område vars särdrag bland annat utgörs av bristen på lagregleringar. Istället bildar avtalen i den så kallade AB-familjen en systematik som fungerar såsom reglering som används och accepteras av de flesta parter på området. Ryggraden, och stommen, i denna systematik utgörs av avtalet AB 04 för generalentreprenader och delade entreprenader, och ABT 06 för totalentreprenader. De övriga avtalen (bland andra AB-U 07, ABT-U 07, ABM 07 och ABK 09) innehåller liknande typer av regler och är utformade för att fungera tillsammans i en kontraktskedja. Under entreprenadarbeten används som regel byggavtalet AB 04 mellan såväl byggherre och entreprenör, som entreprenör och dennes underentreprenörer. Ansvarsfördelningen för en skada på tredje man regleras genom 5:13 i AB 04, och skada på sådana som inte är tredje man i 5:11. Definitionen av vem som utgör tredje man och vem som inte gör det är således central för förståelsen av ansvarsfördelningen mellan beställare och entreprenör. 5:11 och 5:13 skiljer sig åt vad gäller ansvarsform (presumtionsansvar i 5:13, och culpaansvar eller felansvar i 5:11) och placeringen av bevisbördan. Dessutom innehåller 5:11 ansvarsbegränsningar vad gäller beloppet (15 % av kontraktssumman, eller det belopp som ansvarsförsäkring utgör) och industriell produktion eller annan kommersiell verksamhet. Genom den vida skrivningen i 5:13 och genom att ingen praxis finns i frågan finns osäkerhet kring frågan om ansvarsfördelningen. Med tredje man i den betydelse som åsyftas i 5:13 måste, enligt uppsatsens resultat, förstås alla som inte är part i avtalet, undantaget underentreprenörer, underleverantörer och övriga som står i avtalsförhållande med någon av parterna avseende entreprenaden. Det vill säga såväl sådana skadelidande som är helt frikopplade från avtalsparterna, som skadelidande som står i avtalsförhållande med någon av parterna, men inte rörande entreprenaden. Med detta som grund blir effekten att de skadetyper som räknas in under första stycket i 5:13 är alla skador som kan träffa dessa personer som kan vara tredje man. Det finns inget gehör för begränsningar av vad paragrafen är ”åsyftad” att innebära, likt de Byggandets kontraktskommitté (BKK) ger uttryck för i sina yttranden. En osäkerhet av den typ som finns i AB 04 är olämplig, med tanke på de stora skillnader som finns i 5:11 och 5:13. Genom ett förtydligande av paragraf 5:13 vid exempelvis nästa revidering av AB 04, och en anpassad standardiserad försäkringslösning, skulle problematiken enkelt kunna undvikas.

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ALHARBI, SAYER RASHED. "THE ROLE OF BCL-2 FAMILY IN CLINICAL RESPONSE OF CHRONIC LYMPHOCYTIC LEUKEMIA." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1343408194.

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Schmidt, Jonas [Verfasser], and Helmut [Akademischer Betreuer] Salih. "Neutralisation des TNF-Familienmitglieds BAFF durch Belimumab zur Verstärkung der Suszeptibilität von CLL-Zellen gegenüber Therapie mit ABT-199 / Jonas Schmidt ; Betreuer: Helmut Salih." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1189654091/34.

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Jebahi, Abdelghani. "Recherche d'outils d'inhibition de la protéine anti-apoptotique Mcl-1 pour la sensibilisation des cancers de l'ovaire à la molécule BH3-mimétique ABT-737." Caen, 2015. http://www.theses.fr/2015CAEN4014.

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La survie des cancers de l’ovaire dépend des protéines anti-apoptotiques Bcl-xL et Mcl-1. L’inhibition de ces cibles a un potentiel clinique considérable. L’ABT-737 (puissant inhibiteur de Bcl-xL) et son analogue le Navitoclax sont des candidats prometteurs, mais l’état d’expression de Mcl-1 est un déterminant essentiel de leur efficacité. L’inhibition pharmacologique de Mcl-1 représente donc un défi majeur pour le succès clinique du Navitoclax. Nous avons abordé cette problématique de deux façons : par l’inhibition des voies de signalisation contrôlant Mcl-1, et par la recherche d’inhibiteurs directs issus du criblage de la Chimiothèque Nationale Essentielle. Nos travaux sur le BEZ235, double inhibiteur de PI3K et de mTOR, montrent que cette approche inhibe partiellement l’expression de Mcl-1 et induit celle de Puma dans les deux lignées tumorales testées, mais induit BIM dans une seule des deux. Ils montrent également que le BEZ235 sensibilise ces cellules à l’ABT-737 à condition que l’expression de BIM soit induite. Dans les lignées exprimant faiblement BIM après exposition au BEZ235, l’inhibition de ERK1/2 permet de restaurer son expression et de les sensibiliser à l’ABT-737. Nous avons également cherché à identifier des inhibiteurs pharmacologiques directs de Mcl-1, soit au sein d’une famille d’analogues de la molécule MIM1 (4 molécules plus actives) soit parmi les 640 composés de la Chimiothèque Nationale Essentielle. À cet effet, nous avons développé un test spécifique et sélectionné 12 nouveaux inhibiteurs potentiels de Mcl-1. Ces travaux ouvrent d’intéressantes perspectives à l’inhibition de Mcl-1 pour l’amélioration de la prise en charge des cancers de l’ovaire
Ovarian cancers are addicted to Bcl-xL and Mcl-1 anti-apoptotic proteins. Efficient inhibition of these targets is an attractive strategy for the therapeutic management of such disease. Navitoclax, an orally bioavailable analogue of the potent Bcl-xL inhibitor ABT-737, is a promising drug candidate. However, Mcl-1 has been widely described as a key resistance factor to ABT-737. Mcl-1 inhibition thus constitutes a major challenge for the clinical success of Navitoclax. We have addressed this issue with two strategies: inhibiting signaling pathways controlling Mcl-1 expression, and looking for new specific inhibitors by screening a representative sample of the French National Chemical Library (CNE, 640 compounds), selected according to diversity criteria. BEZ235, a dual inhibitor of PI3K/Akt/mTOR pathway, strongly repressed Mcl-1 expression and induced Puma expression in both ovarian carcinoma cell lines tested while differentially modulating BIM. Interestingly, BEZ235 efficiently sensitized ovarian carcinoma cells to ABT-737, provided that BIM expression was induced. Moreover, inhibiting the ERK1/2 pathway restored BIM expression and sensitized low BIM-expressing cancer cells to the BEZ235/ABT-737 treatment. Otherwise, we identified new potential specific Mcl-1 inhibitors. Four small molecules were produced by structural optimization of MIM1, a recently discovered specific Mcl-1 inhibitor. We have also developed a specific functional screening assay and selected 12 hits from « Essential Compound National Library ». These results open interesting perspectives for Mcl-1 targeting for future improvement of the clinical management of ovarian cancers

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Maamer, Azzabi Aida. "Mécanismes moléculaires de l'acquisition d'une sensibilité à l'apoptose induite par l'ABT-737 et d'une résistance à l'anoïkis de cellules coliques métastatiques." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00966853.

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La progression tumorale est la conséquence de multiples altérations génotypiques et phénotypiques; L'une d'entre elles, nécessaire à la formation de métastases, est l'acquisition d'une résistance à l'anoïkis, forme d'apoptose induite par la perte d'attachement à la matrice extra-cellulaire. Afin d'étudier l'anoïkis, nous avons utilisé deux lignées colorectales humaines isogéniques : la lignée SW480 dérivée de la tumeur primaire et sensible à l'anoïkis et la lignée SW620 dérivée d'une métastase ganglionnaire de cette même tumeur et résistante à l'anoïkis. Nous avons établi que dans les cellules SW480, l'anoïkis est une forme d'apoptose intrinsèque c'est-à-dire débutant à la mitochondrie et donc sous le contrôle des protéines de la famille Bcl-2. Parmi celles-ci, nous avons trouvé que seule la protéine proapoptotique à BH3-seul Bim était régulée différemment dans les deux lignées : tandis que son expression augmente de manière très significative dans les cellules SW480 cultivées en suspension, elle n'augmente que très peu dans les cellules SW620. De manière très intéressante, et malgré cette différence, les deux lignées se sont montrées être sensibles au BH3-mimétique ABT-737 mais seulement lorsqu'elles sont cultivées en suspension. Ces résultats indiquent que, qu'elles soient sensibles ou non à l'anoïkis, les cellules détachées sont " prédisposées à la mort " et que des composés semblables à l'ABT-737 tels que le Navitoclax ou l'ABT-199 pourraient avoir des propriétés anti-métastiques dans les tumeurs solides. Dans la seconde partie de ce travail, nous montrons que la protéine transmembranaire CDCP1 ( CUB Domain Containing Protein 1) semble nécessaire mais non suffisante pour protéger ces cellules contre l'anoïkis. CDCP1 est un substrat de Src mais sa phosphorylation sur tyrosine n'est pas impliquée dans cette protection. Finalement, nous avons identifié deux nouvelles protéines qui interagissent avec CDCP1 : l'ITGB4 et l'EphA2

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Herzenstiel, Ines [Verfasser]. "Physikochemische Charakterisierung bioorganischer Filme und deren Einfluss auf die initiale bakterielle Adhäsion / Ines Herzenstiel. Abt. Experimentalphysik : Biophysik und angewandte Nanowissenschaften -- Fakultät für Physik. BASF SE (Ludwigshafen)." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2011. http://d-nb.info/1012215946/34.

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Gerwig, Holger [Verfasser]. "Austausch und Transport luftgetragener schwerflüchtiger chlororganischer Verbindungen in Norddeutschland und über See / Institut für Anorganische und Angewandte Chemie der Universität Hamburg, Abt. Angewandte Analytik. Holger Gerwig." Hamburg : Inst. für Anorganische und Angewandte Chemie der Univ. Hamburg, 2000. http://d-nb.info/959529446/34.

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Sefastsson, Anna-Klara. "Villkor under garantitid i entreprenadförsäkring, en jämförande studie." Thesis, KTH, Fastigheter och byggande, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-153509.

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In Sweden there is no legal regulation for the obligations and responsibilities between the contracting parties within the construction, civil engineering and installation sector. To clarify uncertainties regarding the liability, actors from theses sectors have agreed upon a voluntary regulation, called the General Conditions of Contract. When insurance companies want to enter the Swedish construction insurance market, they face a regulatory framework that not only regulates the construction market, it also imposes requirements on terms and conditions that must be included in the construction insurance. These terms are perceived as ambiguities and create difficulties and inhibit the ability for these insurance companies to offer competitive insurances. One of the terms that create these difficulties is the guarantee period, which is period of time starting from handing over the construction project to the employer, during this period the contractor still has the responsibility for the construction project. The guarantee period regulated by the General Condition of Contracts differs from the international use of the term both in length and in content. The purpose of this thesis is to expose the differences and similarities between the term "guarantee" in comprehensive all risk insurance regulated by the General Conditions of Contract; AB 04 and ABT 06 with two international used insurance policies from reinsurance companies Munich Re and Swiss Re and defect exclusions LEG and DE. The problem discussed in this thesis is whether the exposure of risk for the insurance companies during the guarantee period is comparable or if they deviate? The results presented in this thesis indicates that the guarantee period regulated by AB 04 represents a lower risk exposure than the guarantee period regulated by ABT 06 and that the guarantee period regulated by ABT 06 is most comparable to guarantee period compared in this thesis. The result presented partially confirms simultaneously partially refutes the apprehension insurance companies have regarding the guarantee period according to the General Conditions of Contract, this knowledge about the guarantee period can be used so that more insurance companies can establish on the Swedish construction insurance market.
I Sverige finns ingen lag som reglerar skyldigheter och det ansvar parterna har i entreprenader inom bygg-, anläggnings- och installationssektorn. För att lösa ansvarsfrågan har byggsektorns aktörer enats om en frivillig reglering, Allmänna Bestämmelser. När försäkringsbolag vill ta sig in på den svenska entreprenadförsäkringsmarknaden ställs de inför ett regelverk som inte bara reglerar entreprenadmarknaden utan även ställer krav och villkor på vad entreprenadförsäkringar måste innehålla. Dessa villkor upplevs som främmande och skapar problem för försäkringsbolagen och hämmar möjligheten att erbjuda konkurrensmässiga försäkringar. Ett av dessa villkor som skapar problem är garantitiden, den tid efter avlämnandet, då entreprenören fortfarande har ett ansvar för entreprenaden. Denna garantitid skiljer sig från de internationellt använda försäkringarna både i tid och i omfattning. Syftet med arbetet är att frilägga skillnader och likheter mellan begreppet "garantitid" i allriskförsäkringar enligt Allmänna Bestämmelser AB 04 och ABT 06 respektive två internationellt använda försäkringar från återförsäkringsbolagen Munich Re och Swiss Re och defektundantagen LEG och DE. Frågeställningen som behandlats är om riskexponering är jämförbar i de olika försäkringars garantitider eller om de skiljer sig åt? Resultaten som presenteras i arbetet visar att garantitiden i AB 04 innebär en lägre riskexponering än vad garantitiden i ABT 06 gör och att ABT 06 är den garantitid som är mest jämförbar med garantitider i de jämförande försäkringarna. Genom att detta resultat kan presenteras som delvis bekräftar samtidigt delvis motbevisar den farhåga försäkringsbolag har angående garantitiden enligt AB kan denna kunskap om garantitiden innebära att fler försäkringsbolag kan ta sig in på den svenska entreprenadförsäkringsmarknaden.

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47

Archer, Ricardo. "Kvalitetsprocess för baskartans byggnadsgeometrier : Metod för utvärdering av logisk konsistens i Topocad." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-74502.

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Baskartan innehåller högdetaljerad geografisk information som ligger till grund för olika verksamhets-delar i en kommun. Ajourhållning av baskartan innebär en noggrann och krävande process för att säkerställa dess innehåll. Kvalitetskraven på innehållet varierar utifrån syfte och ändamål samt styrs av olika standarder och riktlinjer. Ett avtal som kommunerna tillsammans med Lantmäteriet kan ingå är, Ajourhållningen av adress- och byggnadsinformation samt information om övrig topografi (ABT-avtal). Avtalet innehåller dataspecifikationer som beskriver bl.a. riktlinjer kring insamling av specifika geodata, dataformat och datakvalitet. I avtalet ingår att leverans av kvalitetssäkrade byggnadsgeometrier ska ske. Avtalets syfte är att kommunerna tillsammans med Lantmäteriet uppnår en hållbar och kvalitativ process kring geografiska data. Syftet med studien var att utveckla, testa och utvärdera en metod i Topocad för att kvalitetssäkra byggnadsgeometrier med avseende på logisk konsistens, enligt ramen för ABT-avtal. Detta för att skapa ett underlag som kan användas för arbetsrutiner vid handhavande av byggnadsgeometrier. Studieområde är Hagfors, en mindre tätort i norra Värmland. I studien presenteras en specifik metod för kvalitetsprocessen i programvaran Topocad med stöd av den kvalitetskontroll som utförs av Lantmäteriets i programvaran FME. Kvalitetsprocessen omfattar kontroll av logisk konsistens och skapande av byggnadsytor. Målet med arbetet är att testa och utvärdera Topocads kapacitet att klassificera och korrigera topologiska fel i polylinjer samt skapande av polygoner. Därför i arbetet har klassificering och korrigering testats och utvärderats för ett urval av felaktiga byggnadsgeometrier genom inbyggda funktioner i Topocad. Därtill har även skapande av polygoner utförts genom en automatiserad funktion utifrån de korrigerade byggnadsgeometrierna. I resultatet framgår att klassificeringen av topologiska fel i Topocad är till viss del icke tillförlitlig. Detta eftersom en specifik typ av polylinjer med lösa noder inte kan klassificeras. Därtill framgår även att det är möjligt att korrigera och kvalitetssäkra de övriga polylinjerna med lösa noder som Topocad klarar att klassificera med hjälp av lämpliga toleransparametrar. Dessutom visar resultatet att det är genomförbart att skapa polygoner av de klassificerade och korrigerade polylinjerna. Samtidigt är polygonernas tillförligtighet och kvalitet helt beroende av de tillämpade toleransparametrarna samt de uppställda kvalitetskraven. Slutsatsen är att det inte är möjligt att utveckla en metod för hela kvalitetsprocessen som kvalitetssäkrar byggnadsgeometrier i Topocad enligt ABT-avtalet. Detta eftersom vissa delar av kvalitetsprocessen är otillförlitliga eller ej genomförbara.
The basemap contains highly detailed geographical information that is the foundation for several functions in the municipalities in Sweden. The upkeep of the basemap involves a specific and ever-evolving process to ensure the quality of its content. The quality requirements for the basemap content vary according to the purpose and are moderated by different standards and guidelines. The Maintenance of Address and Building Information and Information of Other Topography, ABT-agreement (ABT-avtal). This voluntary agreement presents guidelines and encloses data specifications on the gathering of specific geodata, data formats, and the logical consistency of the delivery. One specific part of the agreement includes the delivery of quality-assured building geometries. The agreement offers municipalities and The Department of Land Surveying (Lantmäteriet) in Sweden to enter collectively to construct a sustainable and qualitative process around the geographical information. The purpose of this study was, therefore, to develop and evaluate a quality process for the quality assurance of the building geometries regarding their logical consistency, according to the ABT agreement. This quality process can lead to creating a foundation for correctly handling the building geometries. Therefore, The Department of Land Surveying has contributed with its own quality control process to help the municipalities achieve a higher data quality. The quality control process was created in Feature Manipulation Engine (FME) program. The study area was a small urban area in the town Hagfors, situated in the north eastern part of the county of Värmland, Sweden. The study presents a specific method for the quality process in the software Topocad with the support of The Department of Land Surveying own quality control process. The method content is divided into two different parts that manage with the logical consistency in the polylines and the creation of polygons from the building geometries. The method was to test and evaluate Topocads capacity to classify and correct topological errors in the polylines, but also the creation of polygons. Classification and correction were performed for a selection of incorrect building geometries through program-built functions. In addition, the creation of polygons was also performed for the corrected building geometries through an automated function in Topocad. The result shows that the classification of topological errors in Topocad is, to a certain degree, unreliable. This because Topocad cannot classify a specific type of polylines with loose nodes. Furthermore, it also appears that it is possible to correct the other polylines with loose nodes that Topocad can manage to classify and thereby assure their quality. Moreover, the result shows that it is achievable to create polygons of the classified and corrected polylines in Topocad. At the same time, the reliability of the polygons is entirely dependent on the cluster tolerance applied in the method and the quality requirements established for the results. The study concludes that it is not possible to develop a method for the whole quality process that assure the quality of the building geometries in Topocad, according to the ABT-agreement. This because some parts of the quality process are unreliable or unachievable.

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48

Karl, Christian [Verfasser]. "Wettlauf von Technik und Recht. : Geschichte der Rechtswissenschaft am Karlsruher Institut für Technologie (KIT) als Technische Hochschule. (Abt. B: Abhandlungen zur Europäischen und Deutschen Rechtsgeschichte). / Christian Karl." Berlin : Duncker & Humblot, 2018. http://d-nb.info/1238443222/34.

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49

Blume, Dieter Berno Berno. "Bern von Reichenau (1008-1048): Abt, Gelehrter, Biograph : ein Lebensbild mit Werkverzeichnis sowie Edition und Übersetzung von Berns "Vita S. Uodalrici". Leben des heiligen Bekenners und Bischofs Ulrich /." Ostfildern : Thorbecke, 2008. http://deposit.d-nb.de/cgi-bin/dokserv?id=3111647&prov=M&dokv̲ar=1&doke̲xt=htm.

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50

Pujals, Anaïs. "Etude des mécanismes de résistance à l’apoptose induits par le virus d’Epstein-Barr et mise en place de nouvelles stratégies thérapeutiques pour le traitement des lymphomes B." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T054/document.

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Résumé en français : Notre équipe étudie les mécanismes de l’apoptose induite par la nutline-3, une molécule capable de se fixer sur MDM2 et d’activer la p53, dans différents types de lymphomes associés au virus d’Epstein-Barr (EBV) comme le lymphome de Burkitt (LB) ou syndromes lymphoprolifératifs post-transplantation (PTLD). Nos résultats montrent que la nutline-3 induit l’apoptose des cellules de LB EBV (-) alors que les cellules EBV (+) en latence de type III sont résistantes. Mon travail de thèse a consisté à étudier les mécanismes impliqués dans ce phénomène de résistance afin de mettre en place des stratégies pour les contourner. Une première étude initiée par les résultats d’une analyse transcriptomique, effectuée après traitement avec la nutline-3 de deux lignées qui ne diffèrent que par leur statut EBV, nous a permis de montrer que : 1) l’autophagie est induite en réponse au traitement dans les cellules EBV (+) en latence de type III ; 2) ces cellules expriment fortement Bécline-1 et présentent une activation constitutive de l’autophagie ; 3) l’autophagie contribue à la résistance de ces cellules à l’apoptose. Par ailleurs, nos résultats indiquent que la protéine anti-apoptotique Bcl-2 est également impliquée dans la résistance de ces cellules et que l’utilisation d’ABT-737, un inhibiteur de Bcl-2, restaure leur sensibilité à la nutline-3. L’efficacité de ce composé a donc été évaluée in vivo, seul ou en combinaison avec des traitements conventionnels (Cyclophosphamide pour le LB et Rituximab pour les PTLD). Les résultats obtenus lors de ces études pré-cliniques montrent que : 1) ABT-737 réduit considérablement la croissance tumorale et augmente la survie de souris xénogreffées avec des cellules d’une lignée lymphoblastoïde (LCL, utilisées comme modèle pour les PTLD) alors qu’il n’a pas d’effets chez les souris xénogreffées avec une lignée de LB ; 2) la combinaison BT-737/Cyclophosphamide permet de limiter la croissance tumorale durant le traitement mais n’améliore pas la survie des souris xénogreffées avec une lignée de LB ; 3) l’association ABT-737/Rituximab est très efficace et induit une rémission complète chez 70% des souris xénogreffées avec la lignée de LCL
- Résumé en anglais : Our team is working on the mechanisms of apoptosis induced by nutlin-3, a small molecule which binds to MDM2 and activates p53, in different lymphomas associated with Epstein-Barr virus such as Burkitt lymphoma (BL) or Post-transplant lymphoproliferative disorder (PTLD). Our results show that nutlin-3 strongly induce apoptosis in EBV (-) cells whereas EBV (+) latency III cells are much more resistant. The aim of my PhD project was to study the mechanisms involved in the resistance of EBV (+) latency III cells to apoptosis and to develop new therapeutic strategies to bypass these mechanisms. A transcriptomic analysis was realized after treatment with nutlin-3 of two cell lines which only differs by their EBV status. Based on the results obtained, a study was performed which allow us to show that: 1) autophagy is induced after nutlin-3 treatment in EBV (+) latency III cells; 2) these cells strongly expressed beclin-1 and present a constitutively high level of autophagy; 3) autophagy is involved in the resistance of apoptosis observed in these cells. Furthermore, our results demonstrate that Bcl-2 also contributes to the resistance of EBV (+) latency III cells and that treatment with ABT-737, a Bcl-2 inhibitor, restores their susceptibility to nutlin-3 treatment. We thus assessed the efficiency of this compound in vivo, in monotherapy or associated with conventional treatments (Cyclophosphamide for BL and Rituximab for PTLD). Results obtained during these pre-clinical studies show that: 1) ABT-737 reduces tumor growth and increase the overall survival of mice xenografted with a lymphoblastoïd cell line (LCL, used as a model for PTLD studies) but has no effects on mice xenografed with BL cell lines; 2) the association ABT-737/Cyclophosphamide reduces tumor growth during treatment but doesn’t improve the overall survival of mice xenografed with BL cell lines; 3) the association ABT-737/Rituximab is very efficient and induces 70% of complete remission in mice xenografted with LCL

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