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Journal articles on the topic 'Abguss'

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Author: Grafiati

Published: 25 July 2024

Last updated: 31 July 2024

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1

Jungenitz, Tassilo, Marcel Beining, Tijana Radic, Thomas Deller, Hermann Cuntz, Peter Jedlicka, and Stephan W. Schwarzacher. "Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells." Proceedings of the National Academy of Sciences 115, no. 20 (April 30, 2018): E4670—E4679. http://dx.doi.org/10.1073/pnas.1801889115.

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Adult newborn hippocampal granule cells (abGCs) contribute to spatial learning and memory. abGCs are thought to play a specific role in pattern separation, distinct from developmentally born mature GCs (mGCs). Here we examine at which exact cell age abGCs are synaptically integrated into the adult network and which forms of synaptic plasticity are expressed in abGCs and mGCs. We used virus-mediated labeling of abGCs and mGCs to analyze changes in spine morphology as an indicator of plasticity in rats in vivo. High-frequency stimulation of the medial perforant path induced long-term potentiation in the middle molecular layer (MML) and long-term depression in the nonstimulated outer molecular layer (OML). This stimulation protocol elicited NMDA receptor-dependent homosynaptic spine enlargement in the MML and heterosynaptic spine shrinkage in the inner molecular layer and OML. Both processes were concurrently present on individual dendritic trees of abGCs and mGCs. Spine shrinkage counteracted spine enlargement and thus could play a homeostatic role, normalizing synaptic weights. Structural homosynaptic spine plasticity had a clear onset, appearing in abGCs by 28 d postinjection (dpi), followed by heterosynaptic spine plasticity at 35 dpi, and at 77 dpi was equally as present in mature abGCs as in mGCs. From 35 dpi on, about 60% of abGCs and mGCs showed significant homo- and heterosynaptic plasticity on the single-cell level. This demonstration of structural homo- and heterosynaptic plasticity in abGCs and mGCs defines the time course of the appearance of synaptic plasticity and integration for abGCs.

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2

Luna, Victor M., Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary, et al. "Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus." Science 364, no. 6440 (May 9, 2019): 578–83. http://dx.doi.org/10.1126/science.aat8789.

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Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs throughN-methyl-d-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

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3

Heumer, Wolfgang. "„Elektra“ verzichtet auf Abgase." VDI nachrichten 76, no. 03 (2022): 10. http://dx.doi.org/10.51202/0042-1758-2022-03-10.

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4

Märzhäuser, Helene. "Abgase, die neuen Rohstoffe." Nachrichten aus der Chemie 64, no. 11 (November 2016): 1077–78. http://dx.doi.org/10.1002/nadc.20164056633.

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5

Nusrullah, Muhammad, Muhammad Younus, and Yasir Nasir. "Relationship between Arterial and Venous Blood Gases in Patients Presenting with Chronic Obstructive Pulmonary Disease." Annals of King Edward Medical University 24, no. 1 (April 17, 2018): 684–88. http://dx.doi.org/10.21649/akemu.v24i1.2343.

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Arterial blood gas analysis is an important test for determining acid base balance of the body. Chronic obstructive pulmonary disease is characterized by chronic airflow limitation which is not fully reversible and it can lead to respiratory failure. Objective: To determine the correlation between arterial and venous blood gases in patients presenting with chronic obstructive pulmonary disease. Material and Methods: This cross sectional study was conducted at Department of Chest Medicine, Mayo Hospital, Lahore, Pakistan. After meeting the inclusion criteria, 100 patients were enrolled. Informed consent was taken and demographic information was obtained. Blood sample was obtained anaerobically from the radial artery and from a dorsal hand vein using 2 separate 5cc BD heparinized syringes with needle size 22G for each patientand pH, PCO2, and HCO3 were analyzed. All the collected data was entered and analyzed on SPSS version 21.Results: The mean age of the patients was 52.68±10.51 years. Strong relationship was found between the VBGs and ABGs in pH, PCO2 and HCO3 i.e. r=0.913, 0.999 and 0.994 (p-value <0.0001), respectively. Conclusion: A strong correlation was found among ABG’s and VBGs in patients presenting with COPD.

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6

Corrêa, Dinalva da Silva, and Denise Simões Simões Rodrigues. "Memória política do Pará na voz poética de Abguar Bastos: romance Safra, um eco da resistência na Amazônia." Boitatá 14, no. 27 (December 15, 2019): 145. http://dx.doi.org/10.5433/boitata.2019v14.e37997.

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Este artigo trata de uma pesquisa de Dissertação em andamento. O objetivo é demonstrar comoa influência das posições políticas de Abguar Bastos está presente no romance Safra (1937), pertencente à Série Os dramas da Amazônia. Tem como questões centrais: 1. Abordar de forma breve aspectos da vida e obra de Abguar Bastos; 2. Apresentar a memória política do escritor e por fim, na última seção discutir sobre o romance “Safra”, demonstrando a influência política na obra em relação à educação. Dessa forma, este artigo se caracteriza do ponto de vista metodológico como uma pesquisa qualitativa do tipo bibliográfica e documental. Utilizamos como fundamentação teórica: Halbachw (1990), Bosi (1994), Cândido (2006),Furtado (2008).Conclui-se daí que, a posição política de Abguar se revela na representação de personagens e no problema social da espoliação vivida no cenário amazônico da década de 30.

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7

Wu, An, Bin Yu, Qiyu Chen, Gillian A. Matthews, Chen Lu, Evan Campbell, Kay M. Tye, and Takaki Komiyama. "Context-dependent plasticity of adult-born neurons regulated by cortical feedback." Science Advances 6, no. 42 (October 2020): eabc8319. http://dx.doi.org/10.1126/sciadv.abc8319.

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In a complex and dynamic environment, the brain flexibly adjusts its circuits to preferentially process behaviorally relevant information. Here, we investigated how the olfactory bulb copes with this demand by examining the plasticity of adult-born granule cells (abGCs). We found that learning of olfactory discrimination elevates odor responses of young abGCs and increases their apical dendritic spines. This plasticity did not occur in abGCs during passive odor experience nor in resident granule cells (rGCs) during learning. Furthermore, we found that feedback projections from the piriform cortex show elevated activity during learning, and activating piriform feedback elicited stronger excitatory postsynaptic currents in abGCs than rGCs. Inactivation of piriform feedback blocked abGC plasticity during learning, and activation of piriform feedback during passive experience induced learning-like plasticity of abGCs. Our work describes a neural circuit mechanism that uses adult neurogenesis to update a sensory circuit to flexibly adapt to new behavioral demands.

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8

Hofman, Jean-Marc. "Une collection de plâtres méconnue. Les moulages de sculpture du Moyen Âge français de la Villa Médicis." Studiolo 13, no. 1 (2016): 184–96. http://dx.doi.org/10.3406/studi.2016.1037.

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Eine Sammlung von missverstandenen Gipsabgüssen. Die Abgüsse von Skulpturen des französischen Mittelalters der Villa Im Jahr 1918 bietet Albert Besnard der Villa Medici eine patriotische Propaganda und künstlerische Ausstellung von Gipsabgüssen von mittelalterlichen französischen Skulpturen. Mit dieser Veranstaltung wollte man den Italienern den Kapitalverlust auf französischem Boden beweisen. Dies wurde mit zwei Veranstaltungen, wo der künstlerische und architektonische Reichtum hervorgehoben wurde, unterstrichen. Die Abgüsse mittelalterlichen Skulpturen, benannt “ Musée de Sculpture“ und heute in Villa Medici ausgestellt, sind die letzten Zeugen dieser Veranstaltung und die, im Juni 1919, die französische Kunst in Italien förderte.

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9

Davis, J. Q., T. McLaughlin, and V. Bennett. "Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain." Journal of Cell Biology 121, no. 1 (April 1, 1993): 121–33. http://dx.doi.org/10.1083/jcb.121.1.121.

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A major class of ankyrin-binding glycoproteins have been identified in adult rat brain of 186, 155, and 140 kD that are alternatively spliced products of the same pre-mRNA. Characterization of cDNAs demonstrated that ankyrin-binding glycoproteins (ABGPs) share 72% amino acid sequence identity with chicken neurofascin, a membrane-spanning neural cell adhesion molecule in the Ig super-family expressed in embryonic brain. ABGP polypeptides have the following features consistent with a role as ankyrin-binding proteins in vitro and in vivo: (a) ABGPs and ankyrin associate as pure proteins in a 1:1 molar stoichiometry; (b) the ankyrin-binding site is located in the COOH-terminal 21 kD of ABGP186 which contains the predicted cytoplasmic domain; (c) ABGP186 is expressed at approximately the same levels as ankyrin (15 pmoles/milligram of membrane protein); and (d) ABGP polypeptides are co-expressed with the adult form of ankyrinB late in postnatal development and are colocalized with ankyrinB by immunofluorescence. Similarity in amino acid sequence and conservation of sites of alternative splicing indicate that genes encoding ABGPs and neurofascin share a common ancestor. However, the major differences in developmental expression reported for neurofascin in embryos versus the late postnatal expression of ABGPs suggest that ABGPs and neurofascin represent products of gene duplication events that have subsequently evolved in parallel with distinct roles. The predicted cytoplasmic domains of rat ABGPs and chicken neurofascin are nearly identical to each other and closely related to a group of nervous system cell adhesion molecules with variable extracellular domains, which includes L1, Nr-CAM, and Ng-CAM of vertebrates, and neuroglian of Drosophila. The ankyrin-binding site of rat ABGPs is localized to the C-terminal 200 residues which encompass the cytoplasmic domain, suggesting the hypothesis that ability to associate with ankyrin may be a shared feature of neurofascin and related nervous system cell adhesion molecules.

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10

Krijgsman, Arco, Arjen de Jong, and Rick Breunesse. "Zylinderabschaltung mit Nachexpansion der Abgase." MTZ - Motortechnische Zeitschrift 81, no. 2 (January 10, 2020): 60–65. http://dx.doi.org/10.1007/s35146-019-0168-1.

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11

Kohse-Höinghaus, Katharina. "Chemische Konzepte für saubere Abgase." Nachrichten aus der Chemie 57, no. 12 (December 2009): 1176–81. http://dx.doi.org/10.1002/nadc.200969051.

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12

Rode, Jörg. "Rewe Nord nutzt Wasserstoff-Lkw." Lebensmittel Zeitung 75, no. 36 (2023): 33. http://dx.doi.org/10.51202/0947-7527-2023-36-033.

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13

König, Klaus W. "Holzpellet-Feuer ohne Flamme reinigt das Abgas." Technische Sicherheit 14, no. 05-06 (2024): 28–33. http://dx.doi.org/10.37544/2191-0073-2024-05-06-28.

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Dass Abwärme und ein Teil der Schadstoffe aus dem Abgas zurückgeholt werden können, zeichnet die Brennwerttechnik eines Öl- und Gas-Heizkessels aus. Sie galt lange bei Holzbrennstoffen als nicht machbar. Zur Reinhaltung der Luft gibt es nun eine zusätzliche Option, wenn die Verbrennung ohne Flamme geschieht und Feinstaub aus dem Abgas erst gar nicht entsteht.

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14

Longkumer, Toshisangba, Sunil Parthasarathy, Sujana Ghanta Vemuri, and Dayananda Siddavattam. "OxyR-dependent expression of a novel glutathione S-transferase (Abgst01) gene in Acinetobacter baumannii DS002 and its role in biotransformation of organophosphate insecticides." Microbiology 160, no. 1 (January 1, 2014): 102–12. http://dx.doi.org/10.1099/mic.0.070664-0.

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While screening a genomic library of Acinetobacter baumannii DS002 isolated from organophosphate (OP)-polluted soils, nine ORFs were identified coding for glutathione S-transferase (GST)-like proteins. These GSTs (AbGST01–AbGST09) are phylogenetically related to a number of well-characterized GST classes found in taxonomically diverse groups of organisms. Interestingly, expression of Abgst01 (GenBank accession no. KF151191) was upregulated when the bacterium was grown in the presence of an OP insecticide, methyl parathion (MeP). The gene product, AbGST01, dealkylated MeP to desMeP. An OxyR-binding motif was identified directly upstream of Abgst01. An Abgst–lacZ gene fusion lacking the OxyR-binding site showed a drastic reduction in promoter activity. Very low β-galactosidase activity levels were observed when the Abgst–lacZ fusion was mobilized into an oxyR (GenBank accession no. KF151190) null mutant of A. baumannii DS002, confirming the important role of OxyR. The OxyR-binding sites are not found upstream of other Abgst (Abgst02–Abgst09) genes. However, they contained consensus sequence motifs that can serve as possible target sites for certain well-characterized transcription factors. In support of this observation, the Abgst genes responded differentially to different oxidative stress inducers. The Abgst genes identified in A. baumannii DS002 are found to be conserved highly among all known genome sequences of A. baumannii strains. The versatile ecological adaptability of A. baumannii strains is apparent if sequence conservation is seen together with their involvement in detoxification processes.

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15

Bauer, Uta, Thomas Stein, and Victoria Langer. "Mobilität in klimaneutralen Stadtquartieren – elektrisch, multimodal und vernetzt." Ökologisches Wirtschaften - Fachzeitschrift 33, no. 3 (August 28, 2019): 22. http://dx.doi.org/10.14512/oew340322.

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Lärm, Abgase und Unfallgefahr sind neben der Flächendominanz parkender Pkw zentrale Probleme für die derzeitige Stadt- und Verkehrsentwicklung. Das Projekt „City2Share“ gibt Anhaltspunkte für ökologische Alternativen.

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16

Muse, Dani. "Kosteneffizient Abgase in der Halbleiterindustrie reinigen." UmweltMagazin 49, no. 03 (2019): 46–47. http://dx.doi.org/10.37544/0173-363x-2019-03-46.

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Komplexe Produktionen in der Industrie erfordern oft eine angepasste Abgasreinigung. Diese Anlagen sollen gesetzlichen Regelungen erfüllen, leistungsfähig sein und wenig kosten. Um diese zu verwirklichen, sind die Technologien auf die jeweilige Anwendung abzustimmen. Wichtig ist eine ergebnisoffene Herangehensweise.

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17

ALBUQUERQUE, Gerson Rodrigues, and Raquel Alves ISHII. "A Amazônia acreana de Abguar Bastos." Muiraquitã - Revista de Letras e Humanidades 2, no. 1 (2013): 116–36. http://dx.doi.org/10.29327/210932.2.1-6.

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18

Krehl, Detlef. "Ladungswechsel Austausch des Abgases durch Frischgas." MTZ - Motortechnische Zeitschrift 75, no. 7 (June 18, 2014): 6–7. http://dx.doi.org/10.1007/s35146-014-0377-6.

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19

Gores, Stefan. "Aus Abgas wird Strom." UmweltMagazin 50, no. 01-02 (2020): 12–14. http://dx.doi.org/10.37544/0173-363x-2020-01-02-12.

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In einer Industrielackierung in Geilenkirchen wird im Februar aus einem Umweltproblem ein Paradebeispiel ökologischer Energieerzeugung. Im Hintergrund steht ein intelligentes Konzept eines Aachener Anlagenbauers: In einem ersten Schritt werden Lösemittel aufkonzentriert, um dann in kleinen Gasturbinen mitverbrannt zu werden.

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20

Holz, Stephan. "Mit modernem Flottenmanagement den Kraftstoffverbrauch senken." Logistik für Unternehmen 33, no. 07-08 (2019): 36–37. http://dx.doi.org/10.37544/0930-7834-2019-07-08-36.

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Effizienzsteigerung | Fuhrparkmanager können mit intelligenter Software ihre Klimabilanz positiv beeinflussen und Kosten sparen. Flottenmanagement-Software kann helfen, den Kraftstoffverbrauch nachweislich zu reduzieren und die Leerlaufzeiten der Fahrzeuge zu senken. Das Ergebnis: Weniger schädliche Abgase gelangen in die Luft.

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21

Füeßl, Hermann S. "Fördern Abgase Asthma bei Kids doch nicht?" Pneumo News 7, no. 4 (September 2015): 11–12. http://dx.doi.org/10.1007/s15033-015-0180-1.

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22

Anderson, Sam. "ABGs." AJN, American Journal of Nursing 90, no. 8 (August 1990): 42–46. http://dx.doi.org/10.1097/00000446-199008000-00020.

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23

Luhmann, Hans-Jochen. "Europas Staatsversagen im Abgas-Fall." GWP – Gesellschaft. Wirtschaft. Politik 66, no. 2 (June 12, 2017): 173–80. http://dx.doi.org/10.3224/gwp.v66i2.01.

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24

Stamatelos, Anastassios M., Grigorios C. Koltsakis, and Ioannis P. Kandylas. "Computergestützter Entwurf von Abgas-Nachbehandlungskonzepten." MTZ - Motortechnische Zeitschrift 60, no. 2 (February 1999): 116–24. http://dx.doi.org/10.1007/bf03226495.

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Stamatelos, Anastassios M., Grigorios C. Koltsakis, and Ioannis P. Kandylas. "Computergestützter Entwurf von Abgas-Nachbehandlungskonzepten." MTZ - Motortechnische Zeitschrift 60, no. 3 (March 1999): 194–204. http://dx.doi.org/10.1007/bf03226502.

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26

Koop, Dittmar. "Abwärme aus dem Abgas holen." HLH 74, no. 05 (2023): 20–22. http://dx.doi.org/10.37544/1436-5103-2023-05-20.

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Seit der unsicheren Versorgungssituation im vergangenen Herbst und Winter gewinnen ressourcenschonende Verfahren zur Energiegewinnung an Popularität – so auch die Nutzung von Wärme aus Abgas. Die dafür nötigen Abgaswärmetauscher zählen zu den etablierten Technologien, werden bislang aber dennoch wenig eingesetzt. Umso erstaunlicher ist dies, da sie sich recht schnell bezahlt machen.

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27

Reis, Marcos Valério. "TERRA DE ICAMIABA DE ABGUAR BASTOS E A FUNDAÇÃO DO ROMANCE AMAZÔNICO." Projeto História : Revista do Programa de Estudos Pós-Graduados de História 73 (May 1, 2022): 128–53. http://dx.doi.org/10.23925/2176-2767.2022v73p128-153.

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Este artigo objetiva estabelecer um olhar atento a literatura do escritor e intelectual amazônida, Abguar Bastos e sua imersão literária na composição do Modernismo Amazônico por meio de sua obra Terra de Icamiaba (1931), que pode ser entendida como a materialidade de sua proposta para o Modernismo brasileiro a partir da Amazônia.

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28

Cho, Shin-Gyu, Myungchul Song, Kimleng Chuon, Jin-gon Shim, Seanghun Meas, and Kwang-Hwan Jung. "Heliorhodopsin binds and regulates glutamine synthetase activity." PLOS Biology 20, no. 10 (October 3, 2022): e3001817. http://dx.doi.org/10.1371/journal.pbio.3001817.

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Photoreceptors are light-sensitive proteins found in various organisms that respond to light and relay signals into the cells. Heliorhodopsin, a retinal-binding membrane protein, has been recently discovered, however its function remains unknown. Herein, we investigated the relationship between Actinobacteria bacterium IMCC26103 heliorhodopsin (AbHeR) and an adjacent glutamine synthetase (AbGS) in the same operon. We demonstrate that AbHeR binds to AbGS and regulates AbGS activity. More specifically, the dissociation constant (Kd) value of the binding between AbHeR and AbGS is 6.06 μM. Moreover, the absence of positively charged residues within the intracellular loop of AbHeR impacted Kd value as they serve as critical binding sites for AbGS. We also confirm that AbHeR up-regulates the biosynthetic enzyme activity of AbGS both in vitro and in vivo in the presence of light. GS is a key enzyme involved in nitrogen assimilation that catalyzes the conversion of glutamate and ammonia to glutamine. Hence, the interaction between AbHeR and AbGS may be critical for nitrogen assimilation in Actinobacteria bacterium IMCC26103 as it survives in low-nutrient environments. Overall, the findings of our study describe, for the first time, to the best of our knowledge, a novel function of heliorhodopsin as a regulatory rhodopsin with the capacity to bind and regulate enzyme activity required for nitrogen assimilation.

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29

Horne, Claydell, and David Derrico. "Mastering ABGs." American Journal of Nursing 99, no. 8 (August 1999): 26–32. http://dx.doi.org/10.1097/00000446-199908000-00035.

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30

Pruitt, Bill. "Interpreting ABGs." Nursing 40, no. 7 (July 2010): 31–35. http://dx.doi.org/10.1097/01.nurse.0000383447.25412.d6.

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&NA;. "Interpreting ABGs." Nursing 40, no. 7 (July 2010): 35–36. http://dx.doi.org/10.1097/01.nurse.0000383448.02541.1e.

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32

"Abgase." Nachrichten aus Chemie und Technik 2, no. 24 (April 23, 2010): 244–45. http://dx.doi.org/10.1002/nadc.19540022404.

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"Ungesunde Abgase." Allergo Journal 13, no. 5 (July 2004): 292. http://dx.doi.org/10.1007/bf03361380.

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"Beseitigung nitroser Abgase." Nachrichten aus Chemie und Technik 9, no. 23 (April 24, 2010): 362. http://dx.doi.org/10.1002/nadc.19610092308.

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35

"Norwegische Petroglyphen-Abgüsse." Nachrichten aus Chemie und Technik 12, no. 15 (April 24, 2010): 310. http://dx.doi.org/10.1002/nadc.19640121510.

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36

Laham, Blake J., Isha R. Gore, Casey J. Brown, and Elizabeth Gould. "Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother." eLife 12 (June 4, 2024). http://dx.doi.org/10.7554/elife.90600.3.

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Adult-born granule cells (abGCs) project to the CA2 region of the hippocampus, but it remains unknown how this circuit affects behavioral function. Here, we show that abGC input to the CA2 of adult mice is involved in the retrieval of remote developmental memories of the mother. Ablation of abGCs impaired the ability to discriminate between a caregiving mother and a novel mother, and this ability returned after abGCs were regenerated. Chemogenetic inhibition of projections from abGCs to the CA2 also temporarily prevented the retrieval of remote mother memories. These findings were observed when abGCs were inhibited at 4–6 weeks old, but not when they were inhibited at 10–12 weeks old. We also found that abGCs are necessary for differentiating features of CA2 network activity, including theta-gamma coupling and sharp wave ripples, in response to novel versus familiar social stimuli. Taken together, these findings suggest that abGCs are necessary for neuronal oscillations associated with discriminating between social stimuli, thus enabling retrieval of remote developmental memories of the mother by their adult offspring.

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Brunner, János, Máté Neubrandt, Susan Van-Weert, Tibor Andrási, Felix B. Kleine Borgmann, Sebastian Jessberger, and János Szabadics. "Adult-born granule cells mature through two functionally distinct states." eLife 3 (July 24, 2014). http://dx.doi.org/10.7554/elife.03104.

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Adult-born granule cells (ABGCs) are involved in certain forms of hippocampus-dependent learning and memory. It has been proposed that young but functionally integrated ABGCs (4-weeks-old) specifically contribute to pattern separation functions of the dentate gyrus due to their heightened excitability, whereas old ABGCs (>8 weeks old) lose these capabilities. Measuring multiple cellular and integrative characteristics of 3- 10-week-old individual ABGCs, we show that ABGCs consist of two functionally distinguishable populations showing highly distinct input integration properties (one group being highly sensitive to narrow input intensity ranges while the other group linearly reports input strength) that are largely independent of the cellular age and maturation stage, suggesting that ‘classmate’ cells (born during the same period) can contribute to the network with fundamentally different functions. Thus, ABGCs provide two temporally overlapping but functionally distinct neuronal cell populations, adding a novel level of complexity to our understanding of how life-long neurogenesis contributes to adult brain function.

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"Strengere Vorgaben für Abgase." ENTSORGA-Magazin 40, no. 1 (2021): 58. http://dx.doi.org/10.51202/0933-3754-2021-1-058-2.

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39

"Abgase machen Pollen aggressiver." DMW - Deutsche Medizinische Wochenschrift 140, no. 18 (September 11, 2015): 1333. http://dx.doi.org/10.1055/s-0041-106214.

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40

"Abgase, Allergien und Antioxidanzien." Allergo Journal 16, no. 2 (March 2007): 94. http://dx.doi.org/10.1007/bf03371937.

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41

"Katalytische Nachverbrennung industrieller Abgase." Nachrichten aus Chemie und Technik 12, no. 15 (April 24, 2010): 311. http://dx.doi.org/10.1002/nadc.19640121511.

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Lybrand, Zane R., Sonal Goswami, Jingfei Zhu, Veronica Jarzabek, Nikolas Merlock, Mahafuza Aktar, Courtney Smith, et al. "A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy." Nature Communications 12, no. 1 (March 3, 2021). http://dx.doi.org/10.1038/s41467-021-21649-8.

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AbstractIn the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent seizures (SRS), which can lead to epilepsy. Although abGCs contribute to local inhibitory feedback circuitry, whether they are involved in epileptogenesis remains elusive. Here, we identify a critical window of activity associated with the aberrant maturation of abGCs characterized by abnormal dendrite morphology, ectopic migration, and SRS. Importantly, in a mouse model of temporal lobe epilepsy, silencing aberrant abGCs during this critical period reduces abnormal dendrite morphology, cell migration, and SRS. Using mono-synaptic tracers, we show silencing aberrant abGCs decreases recurrent CA3 back-projections and restores proper cortical connections to the hippocampus. Furthermore, we show that GABA-mediated amplification of intracellular calcium regulates the early critical period of activity. Our results demonstrate that aberrant neurogenesis rewires hippocampal circuitry aggravating epilepsy in mice.

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Naderi, Ghazal, Mahla Asadian, Arash Seifi, Sedigheh Ghourchian, Malihe Talebi, Mohammad Rahbar, Alireza Abdollahi, and Masoumeh Douraghi. "Dissemination of the Acinetobacter baumannii isolates belonging to global clone 2 containing AbGRI resistance islands in a referral hospital." Microbiology Spectrum, August 28, 2023. http://dx.doi.org/10.1128/spectrum.05373-22.

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ABSTRACT Acinetobacter baumannii strains belonging to global clone 2 (GC2) contain resistance islands (AbGRIs), which are composed of genes conferring resistance to older and newer antibiotics. Here, to locate these genes in AbGRIs, the GC2 strains from Tehran, Iran were examined. Among the 170 A . baumannii , 90 isolates were identified as GC2. Of the genes that confer resistance to older antibiotics, tetA(B ), tetR(B) (tetracyclines), strA , and strB (aminoglycosides) were located in AbGRI1 of 65 GC2 isolates (72.2%). Of the other aminoglycosides, the aphA1b was located in AbGRI2-12b (63.6%), AbGRI2-12a (21.2%), or AbGRI2-1 (15.1%). The aacC1 and aadA1 genes were co-located within AbGRI2-1 (5.5%). The armA was located in AbGRI3-4 (77.7%) and AbGRI3 ABI221 (22.2%). Of sulfonamides, the sul1 was located within AbGRI2-1 (5.5%). Of beta-lactams, the bla TEM was located in AbGRI2-12b (42%), AbGRI2-12a (14%), AbGRI2-1 (10%), or AbGRI2 ABI257 (34%). The oxa23 gene conferring resistance to newer antibiotics (carbapenems) was located in AbaR4 (81.1%); of them, the AbaR4 was located within AbGRI1 in 45.2% of the isolates. This study showed that the GC2 isolates, which contained at least one AbGRI, disseminate in the hospital. Hence, it is likely that the AbGRIs play a significant role in conferring resistance to older and newer antibiotics in GC2 isolates from Iran. IMPORTANCE The majority of Acinetobacter baumannii isolates that are resistant to multiple antibiotics belong to one of the two major global clones, namely global clone 1 (GC1) and global clone 2 (GC2). The resistance islands, which contain variable assortments of transposons, integrons, and specific resistance genes, have been characterized in the genome of these GCs. In GC2 A. baumannii, the chromosomally located A. baumannii genomic resistance islands (AbGRIs) carry the genes conferring resistance to older and newer antibiotics. In this context, we tested whether GC2 isolates collected from a referral hospital carry the AbGRIs containing these genes. This study provided evidence for the circulation of the GC2 A. baumannii strains harboring AbGRI resistance islands between different wards of a referral hospital.

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Wallace, Jenelle, Julia Lord, Lasse Dissing-Olesen, Beth Stevens, and Venkatesh N. Murthy. "Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb." eLife 9 (March 9, 2020). http://dx.doi.org/10.7554/elife.50531.

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Microglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are necessary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb. Microglial depletion reduces the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice. Microglia preferentially target their motile processes to interact with mushroom spines on abGCs, and when microglia are absent, abGCs develop smaller spines and receive weaker excitatory synaptic inputs. These results suggest that microglia promote the development of excitatory synapses onto developing abGCs, which may impact the function of these cells in the olfactory circuit.

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Naderi, Ghazal, Mahla Asadian, Pegah Afarinesh Khaki, Mohammadreza Salehi, Alireza Abdollahi, and Masoumeh Douraghi. "Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients." BMC Microbiology 23, no. 1 (August 24, 2023). http://dx.doi.org/10.1186/s12866-023-02961-3.

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Abstract Aim The Acinetobacter baumannii genomic resistance islands (AbGRIs), which were characterized in the genome of the global clone 2 (GC2) A. baumannii contain resistance genes. Here, we aimed to determine the occurrence of AbGRIs in GC2 A. baumannii obtained from COVID-19 patients in a referral hospital in Tehran, Iran. Methods A total of 19 carbapenem-resistant A. baumannii (CRAB) isolates belonging to GC2 and sequence type 2 (ST2), including 17 from COVID-19 patients and two from the devices used in the ICU that the COVID-19 patients were admitted, were examined in this study. Antibiotic susceptibility testing was performed by the disk diffusion method. PCR and PCR mapping, followed by sequencing, were performed to characterize the structure of AbGRI resistance islands in the isolates tested. Results The AbGRI3 was the most frequent resistance island (RI) detected, present in all the 19 isolates, followed by AbGRI1 (15 isolates; 78.9%) and AbGRI2 (three isolates; 15.8%). Notably, AbGRIs were identified in one of the A. baumannii strains, which was isolated from a medical device used in the ICU where COVID-19 patients were admitted. Furthermore, new structures of AbGRI1 and AbGRI3 resistance islands were found in this study, which was the first report of these structures. Conclusions The present study provided evidence for the circulation of the GC2 A. baumannii strains harboring AbGRI resistance islands in a referral hospital in Tehran, Iran. It was found that resistance to several classes of antibiotics in the isolates collected from COVID-19 patients is associated with the resistance genes located within AbGRIs.

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Ji, Qi, Yang Yang, Yun Xiong, Ying-Jie Zhang, Jun Jiang, Li-Ping Zhou, Xiao-Hui Du, Chun-Xiang Wang, and Zhi-Ru Zhu. "Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells." Alzheimer's Research & Therapy 15, no. 1 (October 30, 2023). http://dx.doi.org/10.1186/s13195-023-01337-z.

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Abstract Background The over-activation of adenosine A2A receptors (A2AR) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A2AR blockade possesses neuroprotective effects on AD. Spatial navigation impairment is an early manifestation of cognitive deficits in AD. However, whether A2AR blockade can prevent early impairments in spatial cognitive function and the underlying mechanism is still unclear. Methods A transgenic APP/PS1 mouse model of AD amyloidosis was used in this study. Behavioral tests were conducted to observe the protective effects of A2AR blockade on early spatial memory deficits in 4-month old APP/PS1 mice. To investigate the underlying synaptic mechanism of the protective effects of A2AR blockade, we further examined long-term potentiation (LTP) and network excitation/inhibition balance of dentate gyrus (DG) region, which is relevant to unique synaptic functions of immature adult-born granule cells (abGCs). Subsequently, the protective effects of A2AR blockade on dendritic morphology and synaptic plasticity of 6-week-old abGCs was investigated using retrovirus infection and electrophysiological recordings. The molecular mechanisms underlying neuroprotective properties of A2AR blockade on the synaptic plasticity of abGCs were further explored using molecular biology methods. Results APP/PS1 mice displayed DG-dependent spatial memory deficits at an early stage. Additionally, impaired LTP and an imbalance in network excitation/inhibition were observed in the DG region of APP/PS1 mice, indicating synaptic structural and functional abnormalities of abGCs. A2AR was found to be upregulated in the hippocampus of the APP/PS1 mouse model of AD. Treatment with the selective A2AR antagonist SCH58261 for three weeks significantly ameliorated spatial memory deficits in APP/PS1 mice and markedly restored LTP and network excitation/inhibition balance in the DG region. Moreover, SCH58261 treatment restored dendritic morphology complexity and enhanced synaptic plasticity of abGCs in APP/PS1 mice. Furthermore, SCH58261 treatment alleviated the impairment of synaptic plasticity in abGCs. It achieved this by remodeling the subunit composition of NMDA receptors and increasing the proportion of NR2B receptors in abGCs of APP/PS1 mice. Conclusions Blockade of A2AR improves early spatial memory deficits in APP/PS1 mice, possibly by reversing synaptic defects of abGCs. This finding suggests that A2AR blockade could be a potential therapy for AD.

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Reshef, Ronen, Elena Kudryavitskaya, Haran Shani-Narkiss, Batya Isaacson, Neta Rimmerman, Adi Mizrahi, and Raz Yirmiya. "The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb." eLife 6 (December 18, 2017). http://dx.doi.org/10.7554/elife.30809.

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Microglia play important roles in perinatal neuro- and synapto-genesis. To test the role of microglia in these processes during adulthood, we examined the effects of microglia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622, and abrogated neuronal-microglial communication in CX3C receptor-1 deficient (Cx3cr1−/−) mice. Microglia depletion significantly lowered spine density in young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb. Two-photon time-lapse imaging indicated that microglia depletion reduced spine formation and elimination. Functionally, odor-evoked responses of mitral cells, which are normally inhibited by abGCs, were increased in microglia-depleted mice. In Cx3cr1−/− mice, abGCs exhibited reduced spine density, dynamics and size, concomitantly with reduced contacts between Cx3cr1-deficient microglia and abGCs' dendritic shafts, along with increased proportion of microglia-contacted spines. Thus, during adult neurogenesis, microglia regulate the elimination (pruning), formation, and maintenance of synapses on newborn neurons, contributing to the functional integrity of the olfactory bulb circuitry.

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Sparks, F. T., Z. Liao, W. Li, A. Grosmark, I. Soltesz, and A. Losonczy. "Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy." Nature Communications 11, no. 1 (December 2020). http://dx.doi.org/10.1038/s41467-020-19969-2.

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AbstractTemporal lobe epilepsy (TLE) is characterized by recurrent seizures driven by synchronous neuronal activity. The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways for synchronous discharges in the temporal lobe, though critical microcircuit-level detail is missing from this pathophysiological intuition. In particular, the relative contribution of adult-born (abGC) and mature (mGC) granule cells to epileptiform network events remains unknown. We assess dynamics of abGCs and mGCs during interictal epileptiform discharges (IEDs) in mice with TLE as well as sharp-wave ripples (SPW-Rs) in healthy mice, and find that abGCs and mGCs are desynchronized and differentially recruited by IEDs compared to SPW-Rs. We introduce a neural topic model to explain these observations, and find that epileptic DG networks organize into disjoint, cell-type specific pathological ensembles in which abGCs play an outsized role. Our results characterize identified GC subpopulation dynamics in TLE, and reveal a specific contribution of abGCs to IEDs.

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Kennedy, William M., Jose Carlos Gonzalez, Haeun Lee, Jacques I. Wadiche, and Linda Overstreet-Wadiche. "T-type Ca²⁺channels mediate a critical period of plasticity in adult-born granule cells." Journal of Neuroscience, February 27, 2024, e1503232024. http://dx.doi.org/10.1523/jneurosci.1503-23.2024.

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Adult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that plays an important role in hippocampal function. Various mechanisms have been implicated in this critical period for enhanced plasticity, including minimal GABAergic inhibition and high intrinsic excitability conferred by T-type Ca2+channels. Here we assess the contribution of synaptic inhibition and intrinsic excitability to long-term potentiation (LTP) in abGCs of adult male and female mice using perforated patch recordings. We show that the timing of critical-period plasticity is unaffected by intact GABAergic inhibition such that 4-6 week-old abGCs exhibit LTP that is absent by 8 weeks. Blocking GABAAreceptors, or partial blockade of GABA release from PV and nNos-expressing interneurons by a µ opioid receptor agonist, strongly enhances LTP in 4-week-old GCs, suggesting that minimal inhibition does not underlie critical period plasticity. Instead, the closure of the critical period coincides with a reduction in the contribution of T-type Ca2+channels to intrinsic excitability, and a selective T-type Ca2+channel antagonist prevents LTP in 4-week-old but not mature GCs. Interestingly, whole-cell recordings that facilitate T-type Ca2+channel activity in mature GCs unmasks LTP (with inhibition intact) that is also sensitive to a T-type Ca2+channel antagonist, suggesting T-type channel activity in mature GCs is suppressed by native intracellular signaling. Together these results show that abGCs use T-type channels to overcome inhibition, providing new insight into how high intrinsic excitability provides young abGCs a competitive advantage for experience-dependent synaptic plasticity.Significance statementAdult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that is thought to play an important role in hippocampal function. Here we address the cellular mechanisms that underlie this ‘critical period’ for plasticity. We show that the closure of the critical period corresponds with loss of intrinsic excitability mediated by T-type Ca2+channels and that T-type Ca2+channels promote long-term synaptic plasticity in abGCs despite strong GABAAreceptor-mediated inhibition. Regulation of Ca2+channel function contributes to the loss of excitability and LTP mediated by T-type channels in mature GCs. These results provide insight into how intrinsic excitability and inhibition contribute to plasticity in the dentate gyrus.

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"Allergologie – Abgase verstärken die allergene Wirkung." Aktuelle Dermatologie 41, no. 10 (October 7, 2015): 405. http://dx.doi.org/10.1055/s-0035-1564960.

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