Academic literature on the topic 'Abc-F'
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Journal articles on the topic "Abc-F"
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ZHAO, Li-Xia, Cheng-Ji ZHOU, Arowu TANAKA, et al. "Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2." Biochemical Journal 350, no. 3 (2000): 865–72. http://dx.doi.org/10.1042/bj3500865.
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The ABC1 (ABCA) subfamily of the ATP-binding cassette (ABC) transporter superfamily has a structural feature that distinguishes it from other ABC transporters. Here we report the cloning, molecular characterization and tissue distribution of ABC2/ABCA2, which belongs to the ABC1 subfamily. Rat ABC2 is a protein of 2434 amino acids that has 44.5%, 40.0% and 40.8% identity with mouse ABC1/ABCA1, human ABC3/ABCA3 and human ABCR/ABCA4 respectively. Immunoblot analysis showed that proteins of 260 and 250kDa were detected in COS-1 cells transfected with ABC2 having a haemagglutinin tag, while no band was detected in mock-transfected cells. After incubation with N-glycosidase F, the mobilities of the two proteins increased and a single band was detected, suggesting that ABC2 is a glycoprotein. Photoaffinity labelling with 8-azido-[α-32P]ATP confirmed that ATP binds to the ABC2 protein in the presence of Mg2+. RNA blot analysis showed that ABC2 mRNA is most abundant in rat brain. Examination of brain by in situ hybridization determined that ABC2 is expressed at high levels in the white matter, indicating that it is expressed in the oligodendrocytes. ABC2, therefore, is a glycosylated ABC transporter protein, and may play an especially important role in the brain. In addition, the N-terminal 60-amino-acid sequence of the human ABC1, which was missing from previous reports, has been determined.
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Kumar, Vikas, Shilpi Garg, Lalita Gupta, et al. "Delineating the Role of Aedes aegypti ABC Transporter Gene Family during Mosquito Development and Arboviral Infection via Transcriptome Analyses." Pathogens 10, no. 9 (2021): 1127. http://dx.doi.org/10.3390/pathogens10091127.
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Aedes aegypti acts as a vector for several arboviral diseases that impose a major socio-economic burden. Moreover, the absence of a vaccine against these diseases and drug resistance in mosquitoes necessitates the development of new control strategies for vector-borne diseases. ABC transporters that play a vital role in immunity and other cellular processes in different organisms may act as non-canonical immune molecules against arboviruses, however, their role in mosquito immunity remains unexplored. This study comprehensively analyzed various genetic features of putative ABC transporters and classified them into A-H subfamilies based on their evolutionary relationships. Existing RNA-sequencing data analysis indicated higher expression of cytosolic ABC transporter genes (E & F Subfamily) throughout the mosquito development, while members of other subfamilies exhibited tissue and time-specific expression. Furthermore, comparative gene expression analysis from the microarray dataset of mosquito infected with dengue, yellow fever and West Nile viruses revealed 31 commonly expressed ABC transporters suggesting a potentially conserved transcriptomic signature of arboviral infection. Among these, only a few transporters of ABCA, ABCC and ABCF subfamily were upregulated, while most were downregulated. This indicates the possible involvement of ABC transporters in mosquito immunity.
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Du Toit, Andrea. "ABC-F proteins protect bacterial ribosomes." Nature Reviews Microbiology 14, no. 5 (2016): 267. http://dx.doi.org/10.1038/nrmicro.2016.54.
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Kersley, Susan E. "ABC of change: D, E, F." BMJ 328, no. 7438 (2004): s87.1—s87. http://dx.doi.org/10.1136/bmj.328.7438.s87.
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Dubey, Mukesh K., Dan Funck Jensen, and Magnus Karlsson. "An ATP-Binding Cassette Pleiotropic Drug Transporter Protein Is Required for Xenobiotic Tolerance and Antagonism in the Fungal Biocontrol Agent Clonostachys rosea." Molecular Plant-Microbe Interactions® 27, no. 7 (2014): 725–32. http://dx.doi.org/10.1094/mpmi-12-13-0365-r.
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ATP-binding cassette (ABC) transporters mediate active efflux of natural and synthetic toxicants and are considered to be important for drug tolerance in microorganisms. In biological control agents (BCA), ABC transporters can play important roles in antagonism by providing protection against toxins derived from the fungal prey and by mediating the secretion of endogenous toxins. In the present study, we generated deletion and complementation strains of the ABC transporter abcG5 in the fungal BCA Clonostachys rosea to study its role in xenobiotic tolerance and antagonism. Gene expression analysis shows induced expression of abcG5 in the presence of the Fusarium mycotoxin zearalenone (ZEA), secreted metabolites of F. graminearum, and different classes of fungicides. Phenotypic analysis of abcG5 deletion and complementation strains showed that the deletion strains were more sensitive towards F. graminearum culture filtrates, ZEA, and iprodione- and mefenoxam-based fungicides, thus suggesting the involvement of abcG5 in cell protection. The ΔabcG5 strains displayed reduced antagonism towards F. graminearum in a plate confrontation assay. Furthermore, the ΔabcG5 strains failed to protect barley seedlings from F. graminearium foot rot disease. These data show that the abcG5 ABC transporter is important for xenobiotic tolerance and biocontrol traits in C. rosea.
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Kim, Seon Hwa, and Vladimir Vujanovic. "ATP-Binding Cassette (ABC) Transporters in Fusarium Specific Mycoparasite Sphaerodes mycoparasitica during Biotrophic Mycoparasitism." Applied Sciences 12, no. 15 (2022): 7641. http://dx.doi.org/10.3390/app12157641.
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Recent transcriptomic profiling has revealed importance membrane transporters such as ATP-binding cassette (ABC) transporters in fungal necrotrophic mycoparasites. In this study, RNA-Seq allowed rapid detection of ABC transcripts involved in biotrophic mycoparasitism of Sphaerodes mycoparasitica against the phytopathogenic and mycotoxigenic Fusarium graminearum host, the causal agent of Fusarium head blight (FHB). Transcriptomic analyses of highly expressed S. mycoparasitica genes, and their phylogenetic relationships with other eukaryotic fungi, portrayed the ABC transporters’ evolutionary paths towards biotrophic mycoparasitism. Prior to the in silico phylogenetic analyses, transmission electron microscopy (TEM) was used to confirm the formation of appressorium/haustorium infection structures in S. mycoparasitica during early (1.5 d and 3.5 d) stages of mycoparasitism. Transcripts encoding biotrophy-associated secreted proteins did uncover the enrolment of ABC transporter genes in this specific biocontrol mode of action, while tandem ABC and BUB2 (non-ABC) transcripts seemed to be proper for appressorium development. The next-generation HiSeq transcriptomic profiling of the mycoparasitic hypha samples, revealed 81 transcripts annotated to ABC transporters consisting of a variety of ABC-B (14%), ABC-C (22%), and ABC-G (23%), and to ABC-A, ABC-F, aliphatic sulfonates importer (TC 3.A.1.17.2), BtuF, ribose importer (TC 3.A.1.2.1), and unknown families. The most abundant transcripts belonged to the multidrug resistance exporter (TC 3.A.1.201) subfamily of the ABC-B family, the conjugate transporter (TC 3.A.1.208) subfamily of the ABC-C family, and the pleiotropic drug resistance (PDR) (TC 3.A.1.205) subfamily of the ABC-G family. These findings highlight the significance of ABC transporter genes that control cellular detoxification against toxic substances (e.g., chemical pesticides and mycotoxins) in sustaining a virulence of S. mycoparasitica for effective biotrophic mycoparasitism on the F. graminearum host. The findings of this study provide clues to better understand the biotrophic mycoparasitism of S. mycoparasitica interacting with the Fusarium host, which implies that the ABC transporter group of key proteins is involved in the mycoparasite’s virulence and multidrug resistance to toxic substances including cellular detoxification.
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Ousalem, Farès, Shikha Singh, Olivier Chesneau, John F. Hunt, and Grégory Boël. "ABC-F proteins in mRNA translation and antibiotic resistance." Research in Microbiology 170, no. 8 (2019): 435–47. http://dx.doi.org/10.1016/j.resmic.2019.09.005.
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Alzar-Teruel, María, Fidel Hita-Contreras, Antonio Martínez-Amat, et al. "SARC-F and the Risk of Falling in Middle-Aged and Older Community-Dwelling Postmenopausal Women." International Journal of Environmental Research and Public Health 18, no. 21 (2021): 11570. http://dx.doi.org/10.3390/ijerph182111570.
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(1) Background: The objective of the present study was to determine the ability of the SARC-F questionnaire to identify individuals at risk of falling among middle-aged and older community-dwelling postmenopausal women. (2) Methods: An analytical cross-sectional study was conducted on 157 women (70.80 ± 8.37 years). The SARC-F questionnaire was used to screen for risk of sarcopenia. Fear of falling and balance confidence, as measured by the Falls Efficacy Scale-International (FES-I) and the Activities-Specific balance Scale-16 items (ABC-16) respectively, were used to assess risk of falling. Anxiety and depression (Hospital Anxiety and Depression Scale), fatigue (Fatigue Severity Scale), body mass index, waist-to-hip ratio, and sleep duration were also determined. (3) Results: Logistic regression showed that higher risk of falling as assessed by FES-I was associated with higher SARC-F scores (OR = 1.656), anxiety levels (OR = 1.147), and age (OR = 1.060), while increased SARC-F scores (OR = 1.612), fatigue (OR = 1.044), and shorter sleep duration (OR = 0.75) were related to ABC-16 scores. In addition, a SARC-F cutoff of 1.50 (83.33% sensitivity and 59.13% specificity) and 3.50 (44.44% sensitivity and 89.26% specificity) were shown to be able to discriminate participants at risk of falling according to the FES-I and the ABC-16, respectively. (4) Conclusions: our results show that SARC-F is an independent predictor of the risk of falling among middle-aged and older community-dwelling postmenopausal women.
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Wohl, David A., Yazdan Yazdanpanah, Axel Baumgarten, et al. "LB4. A Phase 3, Randomized, Controlled Clinical Trial of Bictegravir in a Fixed-Dose Combination, B/F/TAF, vs. ABC/DTG/3TC in Treatment-Naïve Adults at Week 96." Open Forum Infectious Diseases 5, suppl_1 (2018): S760—S761. http://dx.doi.org/10.1093/ofid/ofy229.2178.
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Abstract Background Bictegravir (B), a potent INSTI with a high barrier to resistance, is coformulated with emtricitabine (F) and tenofovir alafenamide (TAF) as the FDA-approved single-tablet regimen B/F/TAF. We report Week 96 results from an ongoing phase 3 study comparing B/F/TAF to coformulated dolutegravir, abacavir, and lamivudine (DTG/ABC/3TC) in treatment-naïve adults living with HIV-1. Primary outcome at W48 demonstrated noninferior virologic responses, similar bone and renal profiles, and no viral resistance. Methods We randomized 1:1 HLA-B*5701-negative adults, without HBV and with estimated glomerular filtration rate (eGFR) ≥50 mL/minute to receive blinded B/F/TAF (50/200/25 mg) or DTG/ABC/3TC (50/600/300 mg) with matching placebos QD. Primary endpoint was proportion with HIV-1 RNA <50 copies/mL at W48 (FDA snapshot), with secondary analyses at W96. Noninferiority was assessed with 95% confidence intervals (CI) (12% margin). Other secondary endpoints were safety (adverse events [AEs], laboratory abnormalities) and predefined analyses of bone mineral density (BMD) and measures of renal function (eGFR, proteinuria). Results A total of 629 adults were randomized/treated (314 B/F/TAF, 315 DTG/ABC/3TC). At W96, B/F/TAF was noninferior to DTG/ABC/3TC: 87.9% vs. 89.8%, respectively, achieved HIV-1 RNA <50 copies/mL (difference −1.9%; 95%CI −6.9% to 3.1%, P = 0.45). In per-protocol analysis, 99.6% on B/F/TAF vs. 98.9% on DTG/ABC/3TC achieved HIV-1 RNA <50 copies/mL (P = 0.33). Most common AEs overall were nausea (11% B/F/TAF, 24% DTG/ABC/3TC, P < 0.001), diarrhea (15%, 16%), and headache (13%, 16%). Through W96, no participant had emergent resistance to study drugs. No participant discontinued B/F/TAF due to AEs; five (2%) discontinued DTG/ABC/3TC due to AEs (one after W48). Treatment-related AEs occurred in 28% B/F/TAF vs. 40% DTG/ABC/3TC (P = 0.002); most common was nausea (6%, 17%. P < 0.001). At W96, mean percentage changes in spine and hip BMD were small and similar between groups (table); median change in eGFR was significantly less with B/F/TAF, while median % changes in proteinuria were similar. Conclusion At W96, B/F/TAF was virologically noninferior to DTG/ABC/3TC, with no viral resistance or safety-related discontinuations. B/F/TAF was well tolerated with less nausea than DTG/ABC/3TC and similar bone and renal safety. Disclosures D. A. Wohl, Gilead: Grant Investigator and Scientific Advisor, Consulting fee and Research grant. Y. Yazdanpanah, AbbVie: Consultant, Consulting fee. Bristol-Myers Squibb: Consultant, Consulting fee. Gilead: Consultant, Consulting fee. MSD: Consultant, Consulting fee. Pfizer: Consultant, Consulting fee. Johnson & Johnson: Consultant, Consulting fee. ViiV Healthcare: Consultant, Consulting fee. A. Baumgarten, AbbVie: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. BMS: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. Gilead: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. Janssen-Cilag: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. MSD: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. ViiV: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. A. Clarke, GSK: Scientific Advisor, Consulting fee. Gilead: Conference attendence, Scientific Advisor and Speaker’s Bureau, Conference attendance support, Consulting fee and Speaker honorarium. BMS: Conference attendence, Conference attendance support. Janssen: Conference attendence, Conference attendance support. M. Thompson, Bristol Myers Squibb: Research Contractor, Research support. ViiV Healthcare: Research Contractor, Research support. C. Brinson, Gilead: Investigator, Scientific Advisor and Speaker’s Bureau, Research support and Speaker honorarium. Theratech: Investigator, Research support. BMS: Investigator, Research support. SlieaGen: Investigator, Research support. GSK ViiV: Consultant, Investigator and Scientific Advisor, Consulting fee, Research support and Speaker honorarium. Daiichi Sankyo: Sub Investigator, Research support. Novo Nordisk: Investigator, Research support. Sanofi: Investigator, Research support. Watson: Investigator, Research support. Salix: Investigator, Research support. Janssen: Investigator, Research support. Roche: Investigator, Research support. Colucid: Investigator, Research support. Eisai: Investigator, Research support. Shionogi: Investigator, Research support. Elcelyx: Investigator, Research support. Sangamo: Sub Investigator, Research support. D. Hagins, GlaxoSmithKline: Scientific Advisor and Speaker’s Bureau, Honoraria and Speaker honorarium. ViiV Healthcare: Scientific Advisor and Speaker’s Bureau, Honoraria and Speaker honorarium. Gilead: Scientific Advisor, Honoraria and Speaker honorarium. Bristol-Myers Squibb: Scientific Advisor and Speaker’s Bureau, Honoraria and Speaker honorarium. M. Ramgopal, Gilead: Grant Investigator, Research grant. A. Antinori, AbbVie: Consultant, Consulting fee. BMS: Consultant and Grant Investigator, Consulting fee and Research grant. Gilead: Consultant and Grant Investigator, Consulting fee and Research grant. Janssen-Cilag: Consultant and Grant Investigator, Consulting fee and Research grant. Merck: Consultant, Consulting fee. ViiV Healthcare: Consultant and Grant Investigator, Consulting fee and Research grant. X. Wei, Gilead: Shareholder, Salary and Stock. K. White, Gilead: Employee and Shareholder, Salary and Stock. S. Collins, Gilead: Employee and Shareholder, Salary and Stock. A. Cheng, Gilead: Employee and Shareholder, Salary and Stock. E. Quirk, Gilead: Employee and Shareholder, Salary and Stock. H. Martin, Gilead: Employee and Shareholder, Salary and Stock.
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Liu, Hanbin, Zanru Guo, Shuai He, Hongyao Yin, and Yujun Feng. "Synthesis and self-assembly of ABC linear triblock copolymers to target CO2-responsive multicompartment micelles." RSC Advances 6, no. 89 (2016): 86728–35. http://dx.doi.org/10.1039/c6ra18826e.
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A series of ABC triblock copolymers were synthesized by tailoring the block length, suggesting polymers in a narrow composition window (0.34 ≤ f<sub>F</sub> ≤ 0.38) might transform from spherical micelles to multicompartment micelles upon stimulation of CO<sub>2</sub>.
Dissertations / Theses on the topic "Abc-F"
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Demay, Fanny. "Mécanismes moléculaires impliqués dans la protection du ribosome contre les antibiotiques." Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. https://ged.univ-rennes1.fr/nuxeo/site/esupversions/c2dfb8a5-d6bc-41e6-858f-912fcbc4864b.
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Le travail effectué se concentre sur la caractérisation d’un mécanisme de résistance décrit chez E. faecium. La mutation d'un seul nucléotide sur le gène eat(A) conduit à la substitution d'un acide aminé (T450I) codant pour la forme variante de la protéine Eat(A)v. Cette mutation entraîne une résistance croisée pour différents antibiotiques (Lincosamides, Streptogramines A et Pleuromutilines) qui ciblent tous le centre de transfert peptidique du ribosome. Eat(A) fait partie des protéines ABC-F dont certaines sont des Protéines de Protection du Ribosome, alors que le rôle de la forme sauvage reste inconnu. L’objectif de cette thèse est de caractériser l’activité biologique des deux formes de la protéine Eat(A). La mutation à l'origine du phénotype de résistance est située 3 résidus en amont de l'un des deux sites d'hydrolyse de l'ATP. Une différence dans l'activité ATPase entre la forme native et la forme variante de la protéine peut être à l'origine du mécanisme de résistance. Pour répondre à ces questions, nous avons mis au point une méthode de purification pour obtenir suffisemment de protéine soluble pour effectuer des essais in vitro. Nous avons étudié l'impact de la mutation T450I sur l'activité ATPase des protéines, révélant l’importance de l’isoleucine dans l’activité biologique. Nous avons également développé un système de traduction in vitro à partir d’extraits S30 d’E. faecium pour étudier l'impact des deux protéines Eat(A) sur la traduction en suivant la synthèse de la GFP, avec ou sans antibiotiques. Enfin, nous avons entrepris la caractérisation des interactions entre les deux formes d'Eat(A) et le ribosome d'E. faecium en utilisant la technologie cryo-EM<br>The work carried out focuses on the characterisation of a resistance mechanism described in E. faecium. A single nucleotide mutation in the eat(A) gene leads to the substitution of an amino acid (T450I) coding for the variant form of the Eat(A)v protein. This mutation leads to cross-resistance to different antibiotics (Lincosamides, Streptogramins A and Pleuromutilins) which all target the peptide transfer centre of the ribosome. Eat(A) is one of the ABC-F proteins, some of which are Ribosome Protection Proteins, while the role of the wild type remains unknown. The aim of this thesis is to characterise the biological activity of the two forms of the Eat(A) protein. The mutation causing the resistance phenotype is located 3 residues upstream of one of the two ATP hydrolysissites. A difference in ATPase activity between the native and the variant form of the protein may be at the origin of the resistance mechanism. To address these questions, we developed a purification method to obtain sufficient soluble protein for in vitro assays. We studied the impact of the T450I mutation on the ATPase activity of the proteins, revealing the importance of isoleucine in the biological activity. We also developed an in vitro translation system using E. faecium S30 extracts to study the impact of the two Eat(A) proteins on translation by monitoring GFP synthesis, with or without antibiotics. Finally, we undertook the characterisation of the interactions between the two forms of Eat(A) and the E. faecium ribosome using cryo-EM technology
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Sharkey, Liam Karl Robert. "Functional insights into ABC-F proteins that mediate antibiotic resistance in Gram-positive bacteria." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/12924/.
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Members of the ABC-F subfamily of ATP-binding cassette (ABC) proteins mediate resistance to a broad array of clinically-important antibiotic classes that target the ribosome of Gram-positive pathogens. The mechanism by which the ABC-F proteins mediate antibiotic resistance is poorly defined, although two hypotheses have been proposed; drug efflux and ribosomal protection. Here, this mechanism of resistance was investigated using a combination of bacteriological and biochemical techniques. Results obtained from the bacteriological assays provided preliminary data in support of ribosomal protection. Subsequently, the heterologous expression and purification of two ABC-F proteins, Vga(A) and Lsa(A), allowed the function of these proteins to be assessed in staphylococcal transcription-translation (T/T) reactions. Addition of Vga(A) and Lsa(A) to T/T assays subject to antibiotic inhibition caused drug specific, dose-dependent, rescue of translation. Several previously described resistance phenotypes attributed to these proteins were successfully recapitulated in T/T assays, corroborating the idea that rescue of translation observed in vitro is representative of the action of these proteins in whole cells. Finally, ribosome binding assays showed Lsa(A) to be capable of displacing antibiotics from staphylococcal ribosomes. Collectively, the experiments described in this thesis provide the first direct evidence to support a mechanism of ARE ABC-F resistance based on ribosomal protection.
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Ousalem, Farès. "Rôles physiologiques et fonctionnels des facteurs de traduction appartenant à la famille ABC-F et leur implication dans la résistance aux antibiotiques." Thesis, Université de Paris (2019-....), 2020. http://www.theses.fr/2020UNIP7015.
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Les protéines de la famille ABC-F, universellement retrouvées chez les procaryotes et les eucaryotes, interagissent avec le ribosome. La souche Escherichia coli (MG1655) possède 4 ABC-F paralogues nommés EttA, YheS, YbiT et Uup. J’ai étudié ici le rôle physiologiques et fonctionnels des protéines ABC-F d’E. coli et la protéine MsrD de Streptococcus pneumoniae qui est synthétisée dans E. coli. Mes travaux ont montré que les protéines ABC-F sont importantes pour les bactéries dans des conditions de stress spécifiques. Les bactéries délétées du gène ettA sont plus sensibles au stress salin, les bactéries délétées du gène uup sont plus sensibles au stress acide tandis que la surexpression de la protéine YheS ou MsrD dans les bactéries leurs confèrent une résistance aux macrolides. J’ai également démontré que le gène ettA est important pour la croissance d’E. coli dans des conditions de stress salin et de faible concentration en phosphate quand les acides aminés, le malate ou fumarate sont utilisés comme seule source de carbone. La délétion du gène ettA rend les bactéries plus sensibles au stress salin et engendre une dérégulation de certains gènes liés au métabolisme du malate / glyoxylate ainsi que des gènes impliqués dans l'activité ribosomique. La souche délétée du gène ettA sous-exprime le gène de la malate synthase aceB par une régulation post-transcriptionnelle. La sous-expression de la malate synthase dans des bactéries favorise leurs croissances dans le milieu glyoxylate. La délétion du gène ettA a aussi induit une surexpression de facteur de modulation des ribosomes (RMF) dans le milieu LB, ce qui a provoqué une augmentation de la formation des ribosomes 100S<br>Proteins belonging to the ABC-F family are found in prokaryotes as well as eukaryotes. They interact with the ribosome and are considered as translation factors. The Escherichia coli strain (MG1655) has 4 ABC-F paralogs named: EttA, YheS, YbiT and Uup. Here I present a study of the physiological and functional role of E. coli ABC-F proteins and the Streptococcus pneumoniae MsrD protein. My work has shown that the ABC-F proteins studied are important for bacteria adaptation to stress conditions. Bacteria deleted from the ettA gene are more sensitive to salt stress, bacteria deleted from the uup gene are more sensitive to acid stress while the overexpression of the protein YheS or MsrD in bacteria provide resistance to macrolides. I also demonstrated that the ettA gene is important for the growth of E. coli under conditions of saline stress at low phosphate concentration when the amino acids, malate or fumarate are used as the only carbon source. The deletion of the ettA gene makes bacteria more sensitive to salt stress and causes dysregulation of certain genes linked to the malate / glyoxylate metabolism and genes involved in ribosomal activity. The deleted strain of the ettA gene under-expresses the malate synthase aceB gene by post-transcriptional regulation. The under- expression of malate synthase in bacteria promotes their growth in the glyoxylate medium. The deletion of the ettA gene also induced overexpression of ribosome modulation factor (RMF) in LB medium, which caused an increase in the formation of 100S ribosomes
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Guimarães, Carla Patrícia Pinto. "Os transportadores ABC peroxissomais : estrutura e função da ALDP." Tese, Porto : Edição do Autor, 2004. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000093324.
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Roerig, Peter. "Molekulare und biochemische Charakterisierung humaner peroxisomaler ABC-Transporter /." Aachen : Shaker, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012949492&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Müller, Stefan. "Überkompensatorische Schmerzensgeldbemessung? : ein Beitrag zu den Grundlagen des Paragraph 253 Abs. 2 BGB n. F. /." Karlsruhe : VVW, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015725938&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Villette, Solange. "Étude du rôle des thiorédoxines f dans la mort cellulaire programmée et en réponse à divers stress abiotiques chez la plante modèle Arabidopsis thaliana." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6815.
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La mort cellulaire programmée, ou MCP, est un processus dynamique où les cellules ont la capacité de déclencher et de contrôler leur propre mort. Elle est essentielle et présente chez tous les organismes multicellulaires. Chez les plantes, la MCP permet le développement optimal (ex : formation du xylème, morphologie des feuilles, etc.) de la plante tout en protégeant contre divers stress biotiques et abiotiques (ex : la sécheresse, la chaleur, les UV, etc.). Malgré les avancées de ces dernières années, peu de gènes impliqués dans la mise en place de la MCP induite par les UV-C ont été identifiés chez les plantes. L'objectif était donc de caractériser ces gènes chez Arabidopsis thaliana. L'un des candidats est le gène BI-1, pour Bax Inhibitor-1. Il code pour un facteur anti-apoptotique de la MCP animale également retrouvé chez Arabidopsis thaliana. BI-1 régule aussi le taux de calcium du réticulum endoplasmique, ainsi que la formation des espèces réactives de l'oxygène (ROS), permettant l'activation de la réponse de la cellule au stress. L'expression de ce gène suite à une exposition aux UV-C est augmentée, faisant de lui un candidat pour la réponse aux UV-C. Une fusion du promoteur du gène AtBI-1 au gène rapporteur de la luciférase (pAtBI-1::luciférase) a été insérée dans le génome d'Arabidopsis. Une plante homozygote pour l'insertion de l'ADN-T, 5PL20E, a été isolée. Cette lignée parentale a été ensuite mutagénéisée, et un crible effectué sur la descendance exposée aux UV-C a permis d'identifier un mutant, 2017, dont l'expression de la luciférase était modifiée. Le premier objectif de ce projet était de caractériser ce mutant et de déterminer le lien potentiel avec la régulation de BI-1. Dans une deuxième partie, nous nous sommes intéressés aux rôles des thiorédoxines (TRX) dans la MCP végétale. Ces protéines sont présentes chez tous les organismes vivants. Elles régulent les activités de beaucoup d'enzymes en réduisant leurs ponts disulfures. Peu représentées chez l'homme (deux gènes), elles ont néanmoins un rôle de protection dans la voie de signalisation de l'apoptose. Par contre, chez Arabidopsis, une vingtaine de gènes codant pour les thiorédoxines sont connus. Suite à un autre crible aux UV-C d'une banque de mutants d'insertion, un nouveau mutant pour lequel l'insertion de l'ADN-T était dans le promoteur du gène codant pour la thiorédoxine f1 (AtTRX f1) a été identifié. Chez Arabidopsis, deux gènes codent pour les TRX f. Ces protéines ont d’abord été étudiées en tant que régulateur d’enzymes du cycle de Calvin. Plus récemment, d’autres fonctions ont été attribuées, surtout à la TRX f1. Nous avons obtenu de simples mutants pour les deux gènes et produit par croisement des doubles mutants, pour étudier l'implication des TRX f dans la MCP végétale induite par les UV-C (ultraviolets de type C), le MV (methyl viologen) et l'ABA (acide abscissique). En parallèle, des surexpresseurs de la TRX f1 ont été analysés pour ces mêmes stress abiotiques. L'objectif était de déterminer s'il y a une redondance de fonction entre les deux gènes, puisque ces deux protéines, de la même sous-famille, sont localisées au niveau des chloroplastes. Suite à une induction de la MCP par l'un des stress abiotiques, les réponses observées chez les simples mutants sont similaires à celles des plantes sauvages. Par contre, les doubles mutants paraissent plus résistants aux divers stress, alors que les surexpresseurs semblent nettement plus sensibles que les plantes sauvages. Enfin, un dernier axe a été développé sur le rôle des TRX f dans le contrôle des voies de synthèse et de dégradation de l'amidon pour l'ensemble des plantes de notre essai. Il s'avère que les surexpresseurs produisent une plus grande quantité d'amidon que les plantes sauvages. À l'opposé, les simples mutants ont moins d'amidon au niveau des différents tissus étudiés que les plantes sauvages, et les doubles mutants n'en présentent quasiment pas. La présence d'une quantité plus importante d'amidon chez les surexpresseurs de TRX f influence la sensibilité de ces plantes aux stress abiotiques. À l'inverse, les doubles mutants sont plus résitants à ces mêmes stress, où cette quantité d'amidon est fortement diminuée pour ces plantes.
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Mejcher-Atassi, Sonja. "Reading across modern Arabic literature and art : three case studies: Jabrā Ibrāhīm Jabrā, ʿAbd- al-Raḥmān Munīf, Etel Adnam." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422478.
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Kraus, Katharina. "Der Bewährungswiderruf gemäß 56 f Abs. 1 Satz 1 Nr. 1 StGB und die Unschuldsvermutung : das Urteil des Europäischen Gerichtshofs für Menschenrechte im Fall Böhmer und seine Auswirkungen /." Münster : Lit, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=3020208&prov=M&dok_var=1&dok_ext=htm.
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Ritter, Rüdiger. "Michael F. Runowski, Polnische Orgelmusik nach 1945. Einführung und ausgewählte Beispiele, Saarbrücken (VDM Verlag Dr. Müller) 2009, 83 S., zahlreiche Notenbeispiele und Abb., ISBN 978-3-639-11690-8 [Rezension]." Internationale Arbeitsgemeinschaft für die Musikgeschichte in Mittel- und Osteuropa an der Universität Leipzig, 2012. https://ul.qucosa.de/id/qucosa%3A16091.
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Rezension: Michael F. Runowski, Polnische Orgelmusik nach 1945
Zwar kann die moderne polnische Musik aufgrund des seit 1956 existierenden und seinerzeit so spektakulären Festivals Warszawska Jesien [Warschauer Herbst] auch im Ausland als immerhin in groben Grundzügen bekannt gelten. Da aber – wie Runowski selbst hervorhebt– geistliche Musik auf diesem Festival nie eine größere Rolle spielte, blieb dieser Bereich polnischen Musikschaffens nicht nur im Ausland, sondern auch in Polen selbst einem breiteren Publikum verborgen. Umso interessanter ist die Existenz einer durchgehenden polnischen Orgelmusiktraditionseit Kriegsende bis heute, und doppelt interessant ist diese Existenz angesichts der Spannung zwischen katholischem Glauben und kommunistischem System in der Volksrepublik Polen.
Books on the topic "Abc-F"
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Baumann, Barbara. ABC -- Ein Sechsundzwanzigbuchstabenbuch: Sechsundzwanzig Buchstaben in Bildern ; [d = deutsch, e = english, f = francais, i = italiano, p = portugues, e = espanol]. Hatje Cantz, 2003.
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Geiger, Annette, and Bianca Holtschke, eds. Piktogrammatik. transcript Verlag, 2021. http://dx.doi.org/10.14361/9783839457436.
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Unser Wissen und Denken bildet sich immer auch durch grafisches Darstellen heraus, es wird durch bildliche Zeichen anschaulich und vermittelbar. Doch was bildet man dabei eigentlich ab - als Piktogramm oder Diagramm, als Karte oder Informationsgrafik, als Illustration oder Animation? Zwischen Theorie und Praxis vermittelnd, fragen die Beiträge des Bandes nicht nur, wie die zugrunde liegende Bilderordnung funktioniert, sondern auch, wie sie im Entwurfsprozess entwickelt wird. Es wird deutlich: Gestaltete Bilder geben einer immateriellen Idee eine materielle Form - sie sind Weisen der Welterzeugung. Sie beruhen auf geregelten Verfahren und lassen dennoch Spielraum für gestalterische Freiheiten. Mit Beiträgen von: Annette Geiger, Bianca Holtschke, Hannes Kater, Joosten Mueller, Rolf F. Nohr, Samuel Nyholm, Carolin Scheler, Astrit Schmidt-Burkhardt, Pierre Smolarski, Daniela Stöppel, Lukas R. A. Wilde.
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Barros, Betânia Tanure de. Os dois lados da moeda em fusões e aquisições: O case da F&A dos bancos ABN AMRO, Real, Sudameris e Santander. Elsevier, 2011.
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Urianek, Josef, and Oskar Strassegger. ABC der Buchhaltung (f. Österreich). Linde, Wien, 2002.
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Staff, Cap Math. Percent F: Student Workbook (ABC Ser.). Kendall/Hunt Publishing Company, 1994.
Find full textBook chapters on the topic "Abc-F"
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Greff, Günter, and Simone Fojut. "F." In Das ABC des Call Center Management. Gabler Verlag, 2003. http://dx.doi.org/10.1007/978-3-322-87140-4_6.
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Greff, Günter, and Jan Peter Kruse. "F." In Das ABC des Call Center Management. Gabler Verlag, 1999. http://dx.doi.org/10.1007/978-3-322-92059-1_6.
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Wang, Yue, Qingling Li, Guoqing Liu, et al. "The Ground-State Potential Energy Surface of F-Li2 Polymer." In Proceeding of 2021 International Conference on Wireless Communications, Networking and Applications. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2456-9_111.
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AbstractThe first three-dimensional potential energy surface (PES) for the ground-state of F-Li2 polymer by CCSD(T) method were present. Two Jacobi coordinates, R and θ and the frozen molecular equilibrium geometries were used. We mixed basis sets aug-cc-pCVQZ for the Li atom and aug-cc-pCVDZ for the F atom, with an additional (3s3p2d) set of midbond functions. The total of about 365 points were generated for the PES. Our ab initio calculations were consistent with the experimental data very well.
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Onasch, Paul. "„nicht mehr zu erzählen gewusst als unzuverlässige unsichere Gerüchte“ Zu den Grenzen unzuverlässigen Erzählens in Uwe Johnsons Mutmassungen über Jakob (1959)." In Abhandlungen zur Literaturwissenschaft. J.B. Metzler, 2021. http://dx.doi.org/10.1007/978-3-476-05764-8_8.
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ZusammenfassungIm Aufsatz wird die Frage diskutiert, inwiefern der Erzähler in Uwe Johnsons erstveröffentlichtem Roman Mutmassungen über Jakob den Versuch, die Hintergründe zum Tod der Titelfigur Jakob Abs zu rekonstruieren, auf narratologisch unzuverlässige Weise arrangiert. Ausgehend von Simone Elisabeth Langs These, dass „der Befund zur mimetischen Zuverlässigkeit des Erzählers positiv“ ausfalle, sich das Erzählen im Roman aber „am Rande des Spektrums der erzählerischen Zuverlässigkeit“ bewege (Lang 2016, S. 223), werden Textstellen untersucht, in denen der Erzähler scheinbar auf das Bewusstsein der zu Beginn der Erzählung bereits verstorbenen Titelfigur zurückgreifen kann. Während es sich bei diesen Passagen eindeutig nicht, wie von Lang angenommen, um unmarkierte Wiederholungen von Figurentext im Erzählerbericht handelt (vgl. Lang 2016, S. 219 f.), bleibt aufgrund des artifiziellen Charakters einiger Bewusstseinswiedergaben offen, inwieweit diese womöglich als szenische Vergegenwärtigung des Erzählers gestaltet sind (vgl. Müller 2005, S. 272). Zweifellos nimmt Johnson damit eine mimetische Unzuverlässigkeit in Kauf, spielt bei genauerer Betrachtung mit ihr (vgl. Lang 2016, S. 223), um den poetologischen Anspruch an einen Erzähler zu demaskieren, eine konsistente (Erzähl-)‚Wahrheit‘ präsentieren zu müssen.
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Taura, Kenjiro, Satoshi Matsuoka, and Akinori Yonezawa. "ABCL/f: A future-based polymorphic typed concurrent object-oriented language-Its design and implementation." In Specification of Parallel Algorithms. American Mathematical Society, 1994. http://dx.doi.org/10.1090/dimacs/018/18.
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Hertzig, Stefan. "Krull, Dieter, Dieter Zumpe: Memento Frauenkirche. Dresdens Wahrzeichen als Symbol der Versöhnung. Dresden’s Famous Landmark as a Symbol of Reconciliation. Berlin: Verl. f. Bauwesen 2001. 223 S. m. überwieg. farb. Abb. nebst 1 CD-ROM." In Die Dresdner Frauenkirche. J.B. Metzler, 2002. http://dx.doi.org/10.1007/978-3-476-04392-4_15.
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Benning, Prof Dr iur Axel, Bettina Benning, Prof Dr iur Jörg-Dieter Oberrath, and Ellen Oberrath. "F. Problem-ABC." In Gestaltungsleitfaden AGB. Richard Boorberg Verlag GmbH & Co KG, 2015. http://dx.doi.org/10.5771/9783415054844-225.
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Han, Chang Dae. "Rheology of Block Copolymers." In Rheology and Processing of Polymeric Materials: Volume 1: Polymer Rheology. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780195187823.003.0014.
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Block copolymer consists of two or more long blocks with dissimilar chemical structures which are chemically connected. There are different architectures of block copolymers, namely, AB-type diblock, ABA-type triblock, ABC-type triblock, and AmBn radial or star-shaped block copolymers, as shown schematically in Figure 8.1. The majority of block copolymers has long been synthesized by sequential anionic polymerization, which gives rise to narrow molecular weight distribution, although other synthesis methods (e.g., cationic polymerization, atom transfer radical polymerization) have also been developed in the more recent past. Owing to immiscibility between the constituent blocks, block copolymers above a certain threshold molecular weight form microdomains (10–50 nm in size), the structure of which depends primarily on block composition (or block length ratio). The presence of microdomains confers unique mechanical properties to block copolymers. There are many papers that have dealt with the synthesis and physical/mechanical properties of block copolymers, too many to cite them all here. There are monographs describing the synthesis and physical properties of block copolymers (Aggarwal 1970; Burke and Weiss 1973; Hamley 1998; Holden et al. 1996; Hsieh and Quirk 1996; Noshay and McGrath 1977). Figure 8.2 shows schematically four types of equilibrium microdomain structures observed in block copolymers. Referring to Figure 8.2, it is well established (Helfand and Wasserman 1982; Leibler 1980) that in microphase-separated block copolymers, spherical microdomains are observed when the volume fraction f of one of the blocks is less than approximately 0.15, hexagonally packed cylindrical microdomains are observed when the value of f is between approximately 0.15 and 0.44, and lamellar microdomains are observed when the value of f is between approximately 0.44 and 0.50. Some investigators have observed ordered bicontinuous double-diamonds (OBDD) (Thomas et al. 1986; Hasegawa et al. 1987) or bicontinuous gyroids (Hajduk et al. 1994) at a very narrow range of f (say, between approximately 0.35 and 0.40) for certain block copolymers. Figure 8.2 shows only one half of the symmetricity about f = 0.5. Transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and small-angle neutron scattering (SANS) have long been used to investigate the types of microdomain structures in block copolymers.
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Moersch, Karl-Friedrich. "F." In ABC des Mietrechts. WALHALLA Fachverlag, 2021. http://dx.doi.org/10.5771/9783802947858-81.
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Moersch, Karl-Friedrich. "F." In ABC der Mietnebenkosten. WALHALLA Fachverlag, 2021. http://dx.doi.org/10.5771/9783802955679-121.
Full textConference papers on the topic "Abc-F"
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Vivanco, José Antonio. "Understanding cycling in Quito through the lens of Social Practice Theory." In 24th ISUF 2017 - City and Territory in the Globalization Age. Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/isuf2017.2017.6070.
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Understanding cycling in Quito through the lens of Social Practice Theory. José Antonio Vivanco Viladot The Bartlett School of Planning, University College of London, Central House, 14 Upper Woburn Place, WC1H 0NN, London. E-mail: jose.viladot.15@ucl.ac.uk Keywords: Quito, Ecuador, Social Practice Theory, Transport behavior, Cycling Conference topics and scale: Urban form and social use of space In Quito, the relatively recent development of infrastructure and programs to promote cycling has become central in the discussion for sustainable mobility[1]. Moreover, considering that the scheme ‘Ciclopaseo’ has been an important dominical event for many families over a decade, if compared with the low rates of cycling in the modal share, questions surge about the effectiveness of all these measures. Moreover, the appropriateness of cycling in a city with geographical, morphological, social, and cultural challenges for practitioners has been analysed. The use of Social Practice Theory[2] provides a theoretical framework to understand holistically the daily mobility of two groups: a representative sample composed by University students, gives a specific target for policy making; while a parallel sample puts into perspective the validity of the results. SSPS and ArcGIS are used for the analysis of primary data collected with Google Forms. Overall, the analysis of each one of the elements of practice explains a dimension of the self-reinforcing barriers to cycle. It is revealed that the construction of meanings in daily travel, especially cycling, is based on instrumental factors such as travel time and distance, but non-instrumental factors related to safeness and security weigh heavily in travel behaviour, creating psychological barriers to cycling. It is concluded that reshaping the meanings of cycling is necessary by the construction of a culture of ‘road user behaviour’, the creation of physic-temporal-symbolic spaces to build cycling skills, and later transform the transport system, road infrastructure, streetscape, and the social rhythms of Quito into cycle-friendly spaces. References: [1] Mogollón, D.O. &amp; Albornoz, M.B.B. (2016) ‘La bicicleta y la transformación del espacio público en Quito (2003-2014)’. Letras Verdes. Revista Latinoamericana de Estudios Socioambientales 19, 24-44. [2] Shove, E. (2010) ‘Beyond the ABC: climate change policy and theories of social change’, uofool of Planning. , K.,l life'ollege of London.Environment and planning A, 42(6), 1273-85. Schatzki, T. (2009) ‘Timespace and the organization of social life’. In Shove, E., Trentmann, F. &amp; Wilk, R. Time, consumption and everyday life: Practice, materiality and culture. London: Bloomsbury, 35-48. Schwanen, T. &amp; Lucas, K. (2011) ‘Chapter 1: Understanding Auto Motives’. In Lucas, K., Blumenberg, E. &amp; Weinberger, Auto motives : understanding car use behaviours (Evelyn Blumenberg)
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Farrag, Sayed, and Ihab Mahmoud. "Petrophysical Evaluation and Geochemical Characterization of Abu Roash F Member Abu Gharadig Basin, Western Desert, Egypt." In International Petroleum Technology Conference. IPTC, 2022. http://dx.doi.org/10.2523/iptc-22187-ms.
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Abstract Abu Roash F Member (ARF) is a carbonate formation extended all over the Western Desert in Egypt, ARF has good lateral continuity in all western desert basins but has very poor connectivity and very low permeability. it can be considered as an example of unconventional reservoir. This work aims to evaluate the reservoir quality of Abu Roash "F" Member and compare with the unconventional play commercial developed all over the world. in this study, the key parameters to define reservoir quality; include mineralogy, porosity, water saturation, permeability, organic matter content, Kerogen type and thermal maturity has been investigated. More than 30 Rock-Eval pyrolysis samples from different fields where ARF at significantly different level has been used to evaluate and understand ARF geochemical reservoir quality. On the other side, core and well log data from different fields at different level has been inspected and integrated to evaluate ARF mineralogy, porosity, permeability, water saturation, and identify Potential sweet spots. The results of Rock-Eval analysis show that most of the investigated samples have the total organic carbon content (TOC) values between 1.6 and 6.63 wt% indicating good to very good source rocks and the pyrolysis Yield (PY) ranged from 6 to 20 indicating good to very good potential generation. Based on Tmax and Hydrogen index (HI), the deepest well samples have Tmax values in the range of 435 and 441°C and Hydrogen index (HI) values in the range of 311 to 570 indicating that the organic matter has reached the early to intermediate stages of thermal maturity with dominate kerogen type I-II. While the shallower well samples have Tmax values in the range of 421 and 430°C and Hydrogen index (HI) values in the range of 127 to 687 indicating that the organic matter immature with mixed kerogen type II-III. Petrophysical results supporting that ARF is a carbonate rock deposit under marine conditions and has mixed layer clay (montomonlionite, Kolonite and illite). Numerous techniques to estimate ARF permeability from wireline logs have been investigated, using the available core data porosity permeability relationship has been established. Moreover, the results of petrophysical analysis indicate that Lucia class 3 permeability has good math with core permeability. So, Lucia class 3 permeability can be used to estimate ARF permeability using the calculated effective porosity from well log data. Generally, the results of geochemical and petrophysical evaluation of this study show that ARF has very good reservoir quality comparing with the most of commercially developed unconventional resources all over the world. Moreover, the results show that ARF has a similarity with Eagle Ford Shale in terms of Age, mineralogy, pressure, depth, thickness, and TOC which reflect the potentiality of ARF commercial development.
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Okawara, Hideo. "F-matrix (ABCD-matrix) Circuit Simulation Built in IC Test Program." In 2012 21st Asian Test Symposium (ATS). IEEE, 2012. http://dx.doi.org/10.1109/ats.2012.17.
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Ørstavik, K. H., L. Kornstad, and H. M. Reisner. "LEWIS BLOOD TYPE HAS AN EFFECT ON THE PLASMA CONCENTRATION OF FACTOR VIII." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644062.
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The plasma concentration of factor VIII is influenced by the ABO blood group. Individuals with blood group 0 have a lower concentration of both factor VIII coagulant activity, factor VIII coagulant antigen (VIIICAg) and factor VIII related antigen (VIHRAg) than individuals with group A, B and AB. Thirty percent of the genetic variance of VIIIRAg concentration is due to the ABO blood group. The Lewis substances Lea and Leb are closely related to the A, B and H substances. We therefore examined the effect of the presence of these antigens on the plasma concentration of VIIICAg and VIIIRAg. The material was 74 monozygotic and 84 dizygotic twin pairs and 58 blood donors with ABO blood group 0. VIIICAg was determined by a radioimmunoassay and VIIIRAg was determined by an electroimmunoassay. A higher mean concentration °f VIIICAg (147%) and VIIIRAg (81%) was found in individuals with the Le antigen on their red cell surface compared to the mean concentration of VIIICAg (101%) and VIIIRAg (66%) in individuals who lacked this antigen. The difference was found in individuals with ABO blood group 0 only. Individuals with red cell Lea antigen are non-secretors and individuals who lack this antigen but have the Leb antigen are secretors of the A, B and H substances. The lowest factor VIII concentration was found in group 0 secretors. The effect of the Lewis phenotype on factor VIII concentration is therefore most probably due to an effect of the secretor locus. This finding may have practical implications for the diagnosis of carriers of hemophilia A. it has been shown that information on the ABO blood group improves the discrimination between carriers and normals. We found that the effect of ABO blood group on the total variance of VIIIRAg was higher in secretors (21%) than in non-secretors (8%). Since the frequency of secretors varies widely, it is possible that the importance of the ABO locus in carrier detection is different in different populations. Lewis blood typing in materials of carriers and normals are necessary to determine the effect of the Lewis phenotype in carrier detection.
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Karpatkin, S. "MECHANISMS OF IMMUNOLOGIC THROMBOCYTOPENIA IN INDIVIDUALS AT RISK FOR AIDS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644759.
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HIV-seropositive homosexuals, narcotic addicts and hemophiliacs develop a new syndrome of immunologic thrombocytopenic purpura (ITP) which is clinically indistinguishable from classic autoimmune thrombocytopenic purpura (ATP) with respect to increased megakaryocytes in the bone marrow, peripheral destruction of antibody-coated platelets, negative serology for SLE, response to treatment with prednisone and/or splenectomy. However, their platelet immunologic profiles are different.Homosexuals appear to have an immune complex-mediated mechanism: markedly elevated platelet-bound IgG and C3C4 (3.8 and 4.2-fold greater than classic ATP, respectively), elevated circulating immune complexes (3-fold greater than classic ATP), anti-F(ab')2 antibodies and absence of 7S anti-platelet IgG. There is no inverse correlation between platelet count and platelet-bound IgG or platelet-elutable anti-platelet antibody as in classic ATP.Hemophiliacs appear to have an autoimmune 7S IgG-mediated mechanism similar to classic ATP: inverse relationship betweem platelet count and platelet-bound IgG, r = 0.84, p less than 0.001, 26 df, anti-platelet reactive 7S IgG which reacts by its F(ab')2 domain, (reactive at 60-130 ug/ml compared to control IgG), platelet-elutable anti-platelet antibody. However, these patients also have elevated circulating immune complexes (2.4-fold classic ATP level) and markedly elevated platelet-bound IgG and C3C4 (3.4 and 1.2-fold classic ATP level, respectively). Anti-HIV antibody correlated with circulating immune complexes, r = 0.833, p less than 0.001.Narcotic addicts appear to have a mixture of both mechanisms (immune complex as well as autoimmune 7S IgG): markedly elevated platelet-bound IgG and C3C4 (2.6 and 2.4-fold classic ATP level, respectively), elevated circulating immune complexes (7.3-fold classic ATP level), anti-F(ab')2 antibodies, absence of an inverse correlation between platelet count and platelet-bound IgG. However, these patients do have specific 7S IgG anti-platelet antibody, which reacts by its F(ab')2 domain.F(ab')2antibodies were of the IgG class and correlated with circulating immune complex level. They react with autologous, homologous patient and healthy control F(ab')2 fragments. Some anti-F(ab')2 antibodies have broad reactivity, others are more limited. Some immune complexes were shown to contain HIV antibody. It is postulated that the immune complex platelet deposition noted with homosexual and narcotic addict thrombocytopenia may in part be due to HIV antibody complexes, some of which may exist as anti-antibody complexes.
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Ben Maroof, Muneera Saleh, Mohamad Samir Al Nahhas, William L. Soroka, Andre Leveque, and Simon Spitz. "3D Multiple Attenuation in the F-XY Domain: A Case History from Abu Dhabi." In Abu Dhabi International Petroleum Exhibition and Conference. Society of Petroleum Engineers, 2008. http://dx.doi.org/10.2118/118132-ms.
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Maroof, Muneera Saleh Ben, Mohamed Samir Al Nahhas, William Soroka, Andre Leveque, and Simon Spitz. "3D multiple attenuation in the f‐xy domain: A case history from Abu Dhabi." In SEG Technical Program Expanded Abstracts 2008. Society of Exploration Geophysicists, 2008. http://dx.doi.org/10.1190/1.3063863.
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Zulkarnain, F. "Penggunaan Abu Vulkanik Gunung Sinabung Sumatera Utara untuk Infrastruktur Perumahan Penduduk di Kawasan Bencana F ZULKARNAIN." In SEMINAR NASIONAL Strategi Pengembangan Infrastruktur ke-3. ITP Press, 2017. http://dx.doi.org/10.21063/spi3.1017.125-130.
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Takami, H., W. L. Nichols, S. E. Kaese, R. S. Miller, J. A. Katzmann, and E. J. W. Bowie. "FAB FRAGMENTS OF MONOCLONAL ANTIBODIES SPECIFIC FOR PORCINE PLATELET MEMBRANE GLYCOPROTEINS GP IB ANDGP IIB/IIIA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643513.
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For further study of the porcine hemostatic mechanism, we have prepared murine monoclonal antibodies, and F(ab')2 and Fab fragments, specific for porcine platelet membrane glycoproteins GP lb and GP Ilb/IIIa. To avoid production of antibodies to von Willebrand factor (vWF), mice were immunized with platelets obtained from pigs with severe von Willebrand,s disease. One monoclonal antibody (PP3-4C), of IgG1 subclass, caused 85% inhibition of Ristocetin-induced platelet binding of 125I-vWF (porcine) at ≥12 µg IgG/ml. PP3-4C did not affect ADP or collagen-induced platelet aggregation nor inhibit 125I-fibrinogen (porcine) binding. Pepsin and papain digestion, respectively, were used to prepare PP3-4C F(ab')2 and Fab fragments. PP3-4C F(ab')2 at concentrations ≥12 µg/ml caused 80% inhibition of washed platelet agglutination in the presence of vWF and Ristocetin, whereas Fab fragments at concentrations ≥10 µg/ml caused 60% inhibition. Another monoclonal antibody (PP3-3A), of IgG1 subclass, completely inhibited ADP or collagen-induced platelet aggregation at an IgG concentration of 6 µg/ml. At 10 µg IgG/ml PP3-3A completely inhibited binding either of 125I-fibrinogen or of 125I-vWF to ADP-stimulated porcine platelets. PP3-3A did not affect vWF-dependent Ristocetin-induced platelet agglutination, nor 125I-vWF binding to platelets in the presence of Ristocetin. PP3-3A did not bind to platelets which were treated with 10 mM EDTA at 37°C for 60 min. F(ab')2 and Fab fragments were isolated from PP3-3A pepsin or papain digests. Both types of PP3-3A fragments caused 100% inhibition of ADP-induced platelet aggregation, at concentrations ≥6 yg/ml. Immunoprecipitation of surface-radiolabeled porcine platelets and subsequent SDS-PAGE demonstrated that PP3-4C recognized a glycoprotein with molecular weight of 140,000 (under reducing conditions), and 165,000 (non-reduced). PP3-3A recognized glycoproteins with molecular weights of 115,000 and 100,000 (reduced), and 130,000 and 80,000 (non-reduced). Neither monoclonal antibody bound to human platelets. These monoclonal antibodies to porcine platelet membrane glycoproteins which are analogues of human GP lb and GP Ilb/IIIa will be useful for in vitro and in vivo studies to further understanding of mammalian hemostatic mechanisms.
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Rosa, Pedro, Maykon Silva, Flávio Rocha, and Vinicius Borges. "Propostas de Técnicas de Coexistência entre LTE-U e Wi-Fi em 5 GHz considerando diferentes modulações candidatas 5G." In Escola Regional de Informática de Goiás. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/erigo.2020.13862.
Full textAbstract:
A crescente demanda de conexões móveis do LTE tem como con- sequência a saturação do espectro disponível, motivando as operadoras a bus- carem novos espectros de frequência como a faixa de 5 GHz por não ser licenci- ada e pouco utilizada e tendo os padrões IEEE 802.11a/n/ac do Wi-Fi operando nessa mesma frequência. Esse artigo propõe as técnicas de coexistência LAS e RABS aplicadas nas modulações candidatas à 5G (F-OFDM/UFMC) per- mitindo o LTE-U e Wi-Fi operarem de modo simultâneo, conseguindo melhor desempenho ao tráfego Wi-Fi quando comparadas com a técnica ABS.
Reports on the topic "Abc-F"
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Melidis, Konstantin, and Markus Gruber. Begleitende Evaluierung IWB/EFRE AT 2014-20. Leistungspaket 1: Prioritätsachse 1 – Forschung, technologische Entwicklung und Innovation. Endbericht. Convelop gmbh, 2022. http://dx.doi.org/10.22163/fteval.2022.582.
Full textAbstract:
Die Geschäftsstelle der Österreichischen Raumordnungskonferenz (ÖROK GSt.) hat als Verwaltungsbehörde des österreichischen IWB/EFRE -Programms die Durchführung einer begleitenden Evaluierung des Programms beauftragt, die mit Zuschlagserteilung der Bundesbeschaffung GmbH vom 07.12.2017 an ein Konsortium bestehend aus ÖIR, convelop, KMUFA, ÖAR, ÖGUT sowie Spatial Foresight ging. Die Evaluierung wird in mehreren Leistungspaketen bearbeitet, die sich im Wesentlichen auf die Prioritätsachsen des Programms beziehen, ergänzt um Evaluierungen zu den Bereichen „Governance“, „Kommunikation“ und „Querschnittsthemen“. Die gegenständliche Evaluierung ist ein Bestandteil dieser begleitenden Evaluierung und befasst sich im Kern mit den Maßnahmen der Priorität 1 „Stärkung der regionalen Wettbewerbsfähigkeit durch Forschung, technologische Entwicklung und Innovation“, ergänzt um die Maßnahme 15 „F&I in CO2-Reduktionstechnologien“ (P3) sowie die Maßnahmen 16 „F&T-Infrastruktur (Wien)“ und 17 „Innovationsdienstleistungen (Wien)“ (beide PA4). Mit 226,4 Mio. € decken die behandelten Maßnahmen 42% der EFRE-Mittel des Gesamtprogramms ab. Die Evaluierung zeichnet insgesamt ein überwiegend positives Bild der FTI-Förderung im EFRE, das es gilt, auch in Zukunft aufrechtzuerhalten. Die Empfehlungen der FTI-Evaluierung zielen vor allem auf eine noch klarere Konzeption und Darstellung von FTI-Maßnahmen mit grundsätzlich unterschiedlichen Wirkungslogiken und eine Weiterführung bestehender Bemühungen zur Harmonisierung regional unterschiedlicher Abwicklungsmodi innerhalb dieser Maßnahmen ab. Daneben sollte der Anspruch der Anwendungsorientierung im Lichte der stark wahrgenommenen Grundlagenorientierung in der Praxis reflektiert werden. Auch im Bereich der Datenerfassung und -qualitätsicherung wurden Ansatzpunkte für Verbesserungen aufgezeigt.