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1
Andersson, Elin. "After Action Debriefing (AAD) : Rapport om hur AAD fungerar på Polismyndigheten i Södermanlands län." Thesis, Umeå University, Basic training programme for Police Officers, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-27315.
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Syftet med denna rapport är att undersöka hur After Action Debriefing (AAD) fungerar på polismyndigheten i Södermanlands län. Rapporten har sin utgångspunkt i åsikter från anställda poliser i distriktet i Eskilstuna angående frågor om debriefing. Rapporten fokuserar också på åsikter från ansvarig debriefingledare om debriefingens funktion och slutligen vad lagen (Arbetsmiljöverkets kungörelse) säger om rätten till debriefing. Tillvägagångssätt för insamling av data har skett genom enkäter, intervju samt litteraturstudier. Polisyrket är ett krävande yrke på många sätt, och risken för att utsättas för jobbiga händelser är stor. Då man utsatts för kriser, trauman och jobbiga händelser kan det både vara omstörtande och psykiskt påfrestande. Varje individ påverkas olika av situationer man har utsatts för. Det viktigaste av allt är att det finns professionell hjälp att få på myndigheten för att kunna hantera efterföljande beteende på bästa sätt samt minska risken för psykiska problem. Det finns ett stort behov hos de anställda poliserna till utökad debriefing, men att det finns för lite resurser och motivation till att utveckla det. Vi poliser kommer i allt råare situationer då samhället går mot en mycket hård utveckling. Vi är trots allt vanliga människor som inte tål vad eller hur mycket som helst, det vi möter idag är en tuff verklighet som jag tror kommer att bli allt svårare att hantera och till vår hjälp behövs debriefing.
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Tejkal, Stanislav. "Analýza komunikačního mixu divize AAD společnosti 3M Česko, s.r.o." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1590.
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Předmětem této diplomové práce je analýza komunikačního mixu autoopravárenské divize společnosti 3M Česko, s.r.o. Samotné analýze předcházela stručná charakteristika společnosti, charakteristika trhu z hlediska tržních subjektů a určitých specifk trhu. V samotné analýze jsem hodnotil vyváženost složení komunikačního mixu, používání jednotlivých nástrojů s ohledem na efektivitu vynaložených finančních prostředků.
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Kettani, Othmane. "Modélisation du risque de crédit de contrepartie." Thesis, Paris 1, 2017. http://www.theses.fr/2017PA01E005.
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On définit le risque de contrepartie comme le risque de détérioration de la qualité de crédit entrainant une incapacité de la contrepartie à remplir ses obligations contractuelles. De nos jours, ce risque ne se limite plus aux entreprises, mais s'est également étendu aux banques et autres institutions financières. Par conséquent, toute entité participant aux marchés dérivés OTC est exposée à ce risque. La «Credit Value Adjustment» (CVA) est la valeur de marché du risque de contrepartie. En raison de sa complexité, la mise en œuvre de la CVA demeure l'un des plus grands défis auxquels les banques font face depuis la dernière crise. Pour la plupart d’entre elles, sa mise en production nécessite des changements majeurs de l’infrastructure actuelle. En outre, le régulateur, dont le but est de renforcer la stabilité des marchés financiers, s’est également intéressé à la CVA en introduisant une nouvelle charge en capital liée au risque de contrepartie. Les contributions de notre thèse à la littérature existante sur le sujet se trouvent essentiellement aux chapitres 2, 3 et 4 du manuscrit. Dans les chapitres 2 et 3, nous proposons deux méthodes innovatrices pour le calcul de la CVA. Le chapitre 4 est, quant à lui, entièrement dédié à l’étude de la charge en capital réglementaire sous la régulation FRTB-CVACounterparty risk is defined as the risk of credit worthiness deterioration, making the counterparty unable to meet its contractual obligations. Nowadays, this risk is no longer confined to corporate clients but has spread out to other banks and financial institutions. As a consequence, any firm participating in the over-the-counter (OTC) derivatives market is exposed to this risk. Credit Value Adjustment (CVA) is the market value of counterparty credit risk. Implementation of CVA still remains one of the biggest challenges banks face since the last financial crisis, due to its complexity and cost of implementation. For most banks, pricing the whole CVA book requires major changes on the infrastructure they currently have. Furthermore, regulatory responses to the last financial turmoil aimed at strengthening the financial system by introducing new capital requirements. The Basel III regulatory standard was developed in this respect, prescribing an additional capital charge to cover CVA losses.Our contributions to the relevant literature are chapters 2, 3 and 4. In chapters 2 and 3, we propose two innovative approaches to compute CVA that allow a huge reduction in computational costs. Chapter 4 is devoted to the study of the CVA capital charge under the new FRTB-CVA regulation
4
Jayakumar, Jaisubash. "The role of IL-4 receptor alpha in chronic allergic airway disease (AAD)." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3166.
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Leichner, Teri Lynn. "Adaptation of Three Different Apoptotic Methods in Equine Bronchoalveolar Cells and Comparison of Bronchoalveolar Lavage Cell Apoptosis in Normal and COPD Affected Horses Before and After Dexamethasone Administration." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34047.
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Recent studies suggest that lymphocyte apoptosis serves to regulate pulmonary inflammation. Equine COPD, an allergic disease of the lower airway, is likely due to dysregulation of the pulmonary immune response. In this study, the hypothesis tested was COPD affected horses would have less apoptotic airway lymphocytes than control horses during clinical disease. To achieve this, 3 methods of measuring apoptosis, Vindelov's propidium iodide with Triton-X (PI/Triton-X), 7-aminoactinomycin D (7-AAD), and Annexin V with propidium iodide (Annexin/PI) were evaluated in equine airway lymphocytes. A significant linear relationship was found for equine bronchoalveolar lavage (BAL) lymphocytes stained with 7-AAD and Annexin/PI . No relationship was identified with cells stained with PI/Triton-X and Annexin/PI, and 7-AAD and PI/Triton-X indicating that methods which preserve cell membrane characteristics are more comparable when measuring BAL lymphocytes apoptosis in a heterogeneous population of cells. Additionally, all stains appear to perform the same in COPD and normal horses in remission and disease.
Comparison of predominately BAL lymphocyte apoptosis using the above methods were performed at baseline, after natural challenge, and after dexamethasone administration in nine horses, five of which were affected with COPD. No differences in bronchoalveolar lavage lymphocyte apoptosis between COPD and control horses were detected either before or after dexamethasone administration, although numerical trends in COPD horses identified less apoptosis after natural challenge indicating that defective apoptosis may play a role in equine COPD pathogenesis. Dexamethasone administration was associated with trends of improvement in the pulmonary gas exchange and increased apoptosis toward baseline in the COPD horses.Master of Science
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Dublish, Sandipa. "Advertising effects on brand search and preference: assessing the mediational role of Aad and Ab." FIU Digital Commons, 1997. http://digitalcommons.fiu.edu/etd/3093.
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Most advertising research has focussed at examining effects of advertising on attitudinal responses or brand preference and choice. However, in a natural environment, the time period between advertising exposure and purchase decision is filled with prepurchase search. Prepurchase external search refers to information search from sources other than memory, prior to making a purchase decision. Usually consumers access only a small subset of available information and base their choice decisions on it. Prepurchase search therefore acts as a filter and, the final choice depends critically on the small subset of potential inputs the consumer notes in the environment and integrates into the decision. Previous research has identified a variety of factors that affect consumers' prepurchase search behavior. However, there is little understanding of how specific advertisements designed by marketers impact consumers' prepurchase search. A marketer would like consumers to search information that reflects favorably on his/her brand. Hence, s/he would attempt to influence the brands and attributes on which consumers seek information prior to making a choice. The dissertation investigates the process by which a particular marketer's advertising influences consumers' search on available brands, i.e., the marketer's brand and other competing brands. The dissertation considers a situation where exposure to advertising occurs prior to seeking information from any other source. Hence, the impact of advertising on subsequent search behavior is the topic of interest. The dissertation develops a conceptual model of advertising effects on brand search and conducts two experiments to test the tenets of this model. Specifically, the dissertation demonstrates that attitudinal responses generated by advertising mediate advertising effects on search attitudes and behaviors. The dissertation goes on to examine how attitudinal responses generated by advertising and subsequent effects on search alter brand preference and choice.
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Dupuy, Lucile. "Conception et validation d'une assistance numérique domiciliaire pour la personne âgée en perte d'autonomie." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0422/document.
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Avec le vieillissement de la population, le maintien à domicile des personnes âgées est devenu un enjeu majeur pour les pays développés et émergents. Parmi les solutions clés à explorer, les gérontechnologies sont considérées comme des plus prometteuses sans toutefois avoir apporté la preuve de leur efficacité pour l’autonomie domiciliaire, voire même être utilisables et acceptables pour le public visé. Dans ce contexte, une méthodologie de conception centrée-utilisateur a été mise en place pour proposer une plateforme d’assistance domiciliaire multi-tâches et multi-domaines (soutenant à la fois les activités quotidiennes, la sécurité de la personne et de son domicile et le lien social) ciblant un public âgé fragile en perte d’autonomie. Cette plateforme est appelée DomAssist. Sur la base d’une analyse des capacités physiques, cognitives et fonctionnelles en présence (étude 1) et des besoins d’assistance (étude 2) de notre échantillon d’étude, DomAssist a été conçu avec pour originalité une offre de services multi-domaines. En effet, la plateforme s’appuie d’une part sur un système de surveillance d’activités pour délivrer des assistances dites « context-aware » (étude 3) et d’autre part sur un système d’interaction homme-machine unifié et simplifié (étude 4), et ceci tout en promouvant l’auto-détermination (étude 5). Les résultats ont étayé la fiabilité du système de surveillance d’activités, et renforcé le bien-fondé de nos principes de conception concernant le système unifié d’interaction; et le soutien de l’auto-détermination. Notamment un rendu positif concernant l’utilisabilité et l’acceptabilité du système, et un effet bénéfique sur le sentiment de l’autodétermination des utilisateurs âgés ont été obtenus. De là, une dernière étude (étude 6) a évalué les bénéfices apportés après 6 mois d’utilisation de la plateforme, en termes de capacités fonctionnelles des participants fragiles, et de réduction du fardeau de l’aidant. Un effet positif (effet « protecteur » observé par les aidants professionnels) de DomAssist sur le statut fonctionnel des participants équipés (comparé aux contrôles) a été observé ainsi qu’une réduction du fardeau objectif de leur aidant. Au total, les résultats de ce travail pilote sont encourageants et ouvrent de nombreuses perspectives de recherche à fort potentiel d’impact sociétal concernant la problématique du maintien à domicile des personnes âgéesWith the increase of life expectancy, aging in place is today a major concern for developed and emerging countries. Among the key solutions to explore, gerontechnologies are seen as the most promising. However, their evidence-based efficacy remains to be demonstrated for independent living or even for their usability and acceptance by the targeted old users. In this context, a user-centered conception methodology has been implemented for designing a multi-task and multi-domain (supporting everyday activities, safety, and social participation) assisted living platform targeting frail older adults with functional decline. This platform is named HomeAssist. Based on an analysis of physical, cognitive and fonctional abilities (study 1) and assistive technology needs (study 2) of our sample, HomeAssist has been designed with the originality of providing multi-domain services. Indeed, HomeAssist proposes an activity monitoring system to provide context-aware assistance (study 3), and a unified human-computer interaction system (study 4); while promoting self-determination (study 5). Results underpined the reliability of our activity monitoring system, and reinforced the rationale of our design principles, concerning the unified interaction system and the self-determination support. Notably, positive outcomes in terms of usability and acceptance of the system, as well as benefits concerning users’ feeling of self-determination have been obtained. From this, a last study (study 6) evaluated the benefits from a six-month use of HomeAssist, on functional abilities of frail older adults and caregiver burden. A positive effect of HomeAssist on functional status was obtained (“protective” effect reported by the professional caregivers), as well as a reduction of objective dimension of caregiver burden. Taken together, the results from these pilot studies are encouraging and open numerous research perspectives with high societal impact concerning the promotion of aging in place
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Grant, Philip. "Exploring Branded Flash Mobs : A study of the impact of branded flash mobs on consumer behavior and consumer experience." Doctoral thesis, KTH, Industriell marknadsföring, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-145132.
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The desire of every marketer is to develop and maintain strong customer relationships. One way this can be accomplished is through effective advertising. Marketers have recently begun to brand flash mobs as a way to effectuate strong brand relationships. Even so, it is unclear whether or not the branding of flash mobs supports or frustrates this pursuit. Therefore, the goal of this thesis is to help marketers understand the potential impact that branded flash mobs may have on consumer behaviour and brand relationships. Since these interactions are complex we need to observe the convoluted whole from untangled vantage points. Marketing scholars and researchers must then attempt to understand the latent opportunities and unsuspecting dangers when branding a flash mob. Toward answering this end, four distinct research studies were used to examine the phenomenon from four different perspectives. The aim of the first paper is twofold. First, it deductively seeks to understand how to categorize branded flash mobs within the marketing literature through an historical and cultural analysis of the phenomenon. Exploratory in nature, this study then employs a mixed methods approach to understand how marketers are currently using flash mobs, and more importantly, if branded flash mobs are an effective tool of communication and persuasion. In the second paper, a field experiment was conducted to assess the impact of a branded flash mob on consumers’ emotions, consumer experience and connectedness in a public market. Qualitative interviews were used to capture the data. Shifting perspectives, the third paper seeks to understand why some branded flash mobs fail to ‘go viral’. Using of a number of focus groups, participants were asked to watch several branded flash mob videos and discuss their willingness to share them online (e.g., email, Facebook, or Twitter). Toward a better understanding of the impact of branded flash mobs on brand equity, the final paper evaluates viewers’ attitude toward the ad. Using netnographic techniques (Kozinets, 2002) 2,882 YouTube comments from three virally successful branded flash mobs ads were examined to understand how branded flash mobs affect brand equity. Responses grouped into one of four archetypical attitudes, each of which has a distinct impact on brand equity. Motivated by the potential for widespread exposure at a relatively low cost, marketers continue to produce branded flash mobs. Sometimes they are fresh and creative, while at others they are out of tune with the spirit of the phenomenon. This thesis uncovers the impact of these efforts on consumer behaviour and brand equity, and concludes with a guide for managers to consider when planning their next branded flash mob. An acknowledgement of the limitations and an outline for directions of future research are also presented.QC 20140521
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Patel, Akash. "CT Findings of Pulmonary Hypertension." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623619.
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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.Primary pulmonary hypertension (PPH) has an extremely poor prognosis with a mean survival time of 2‐3 years from time of diagnosis. Hemodynamically, PPH is defined with a mPAP of ≥ 25 mm Hg. Currently, RHC is the gold standard for measuring the arterial pressures and diagnosing PPH; however, it is an incredibly invasive procedure. Our study will show whether CT angiography can be considered as a non‐invasive alternative for diagnosing PPH. Studies in the past have shown CT measurements of the MPAD and MPAD/AAD ratio having strong correlations with PPH. In addition to those measurements, we want to show if other CT parameters also have a correlation with PPH. Some of these novel measurements include the interventricular septal deviation and the Elizabeth Taylor sign. The interventricular septum is normally bowing to the right in a non‐pathological state. If it is straight or bowing to the left, this will indicate increased right ventricular pressures which would be indicative of PPH. Straight will indicate increased RV pressures, and bowing to the left will be considered markedly increased RV pressures. The Elizabeth Taylor sign is the ratio of the diameter of the segmental bronchi and its corresponding artery. We will hypothesize that the artery will be much larger than the bronchi in patients with PPH. Other measurements will include the left and right pulmonary arteries. This study is a retrospective review of subjects who underwent an otherwise unremarkable CT pulmonary artery angiogram. Subjects with pulmonary embolism or other acute pulmonary diseases are excluded. For each subject, the following CT findings are obtained: main pulmonary artery diameter (mPAD), ratio of mPAD to ascending aorta, right and left pulmonary artery diameters, ratio of segmental pulmonary artery to corresponding bronchus, and interventricular septal displacement. Straightening of the interventricular septum qualifies as increased right ventricular septal pressure and right‐to‐left bowing of the septum qualifies as a marked increase. Mean pulmonary artery pressure measured on any prior/subsequent RHC or echocardiogram within 3 months of the CT is recorded. Any past medical history of connective tissue disease is noted. Descriptive data are calculated and correlations are done to assess for presence and strength of associations among variables. Data from 484 subjects are collected. Incidence rate of pulmonary hypertension isv13% (n=63). 52% (n=33) of the subjects with pulmonary hypertension are female with an average age of 55 years. mPA diameter (p<0.001), mPA:AA ratio (p<0.001), right (p<0.001) and left pulmonary artery (p=0.004) diameters are predictors of pulmonary hypertension. sPA:B ratio (p=0.08) and interventricular septal displacement (p=0.96) are not predictive of pulmonary hypertension. This study supports an association of mPA diameter, mPA:AA ratio, right and left pulmonary artery diameters with pulmonary hypertension diagnosed by RHC or echocardiogram. Prospective research is warranted to confirm and establish threshold values for each variable. Currently, an invasive RHC remains the most accurate method of diagnosis. Correlating CT findings with pulmonary hypertension would allow clinicians to use CT as a noninvasive screening tool.
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Kluger, Lotta Clara [Verfasser], Matthias [Akademischer Betreuer] [Gutachter] Wolff, and Aad [Gutachter] Smaal. "Ecological and socio-economic feasibility of scallop bottom culture in Sechura Bay, Northern Peru / Lotta Clara Kluger ; Gutachter: Matthias Wolff, Aad Smaal ; Betreuer: Matthias Wolff." Bremen : Staats- und Universitätsbibliothek Bremen, 2016. http://d-nb.info/112319467X/34.
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MacKenzie, Jason Roderick, and Jason Mackenzie@ipaustralia gov au. "The Role of Eosinophils in the Regulation of CD4+ T helper 2 Regulated Inflammation." The Australian National University. The John Curtin School of Medical Research, 2004. http://thesis.anu.edu.au./public/adt-ANU20051007.121844.
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The eosinophil is a leukocyte whose intracellular mediators are considered to play a
central role in the pathogenesis of allergic diseases, including allergic asthma, allergic
rhinitis and atopic dermatitis, and which is also involved in immunological responses to
parasites. Eosinophil differentiation and maturation from bone marrow progenitors is
regulated by interleukin-5 (IL-5), which may be secreted by T helper 2 (Th2) T
lymphocytes, and is consistently upregulated in allergic conditions. Eotaxin is a potent
chemoattractant for circulating and tissue eosinophils, and the production of this
chemokine promotes eosinophil infiltration and accumulation within sites of allergic
inflammation.¶
Eosinophils obtained from inflammatory tissues and secretions display an altered
phenotype in comparison to peripheral blood eosinophils, with increased surface
expression of major histocompatibility complex (MHC) proteins and adhesion
molecules (Hansel et al., 1991), and migration across the microvascular endothelium
may also increase their capacity to generate an oxidative burst (Walker et al., 1993;
Yamamoto et al., 2000). Eosinophils are phagocytic cells, and have been shown to
present simple (no requirement for intracellular processing) and complex antigens to
MHC-restricted, antigen-specific T lymphocytes (Del Pozo et al., 1992; Weller et al.,
1993). Furthermore, eosinophils express the costimulatory molecules required for
effective antigen presentation (Tamura et al., 1996), and ligation of costimulatory
molecules on the eosinophil cell surface can induce the release of eosinophil derived
cytokines (Woerly et al., 1999; Woerly et al., 2002). Therefore the eosinophil may also
regulate immune responses.¶
To date, no studies have demonstrated the ability of eosinophils to modulate activated T
lymphocyte function via presentation of relevant antigen in the context of MHC class II
(MHC-II), concomitant with Th2 cytokine release. In the experiments described in this
thesis, murine eosinophils have been observed to rapidly migrate to sites of antigen
deposition within the airways mucosa of naïve mice, suggesting a potential role for this
granulocyte in the primary response to inhaled antigen. However, human allergic
diseases are often diagnosed after the establishment of allergic responses, and symptom
development. Therefore, a murine model of allergic airways disease (AAD) was used to
investigate the ability for eosinophils to participate as antigen presenting cells (APCs),
and thereby modulate activated T lymphocyte function both in vitro and in vivo.
Detailed histological analysis of the pulmonary draining lymph nodes following antigen
challenge in sensitised mice revealed a rapid infiltration of eosinophils into this tissue,
which preceded the accumulation of eosinophils in bronchoalveolar lavage fluid
(BALF). This suggested that eosinophils were preferentially translocating to the
draining lymph nodes following antigen challenge, and that the subsequent
accumulation of these cells in the BALF was a consequence of continued antigen
delivery to the lower airways.¶
Eosinophil trafficking to lymphoid tissue via the afferent lymphatics was substantiated
using electron microscopy of lymph node sections and the intravenous (i.v.) transfer of
fluorescently labeled eosinophils, which did not traffic to lymph nodes via the blood.
During the resolution of AAD, eosinophils were noted for their persistence in the
pulmonary draining lymph nodes. These observations suggested a continued modulation
of T cell function by lymph node dwelling eosinophils during AAD resolution,
particularly in light of recent observations for draining lymph node T cell proliferation
following instillation of antigen-pulsed eosinophils into the allergic mouse lung (Shi et
al., 2000).¶
To further investigate the antigen presenting capacity, eosinophils were obtained from
the BALF of mice with AAD, and their surface expression of MHC class II (MHC-II)
proteins and costimulatory molecules confirmed using flow cytometric analysis. The
ability to acquire and process complex antigen both in vitro and in vivo was also
confirmed using naturally quenching fluorescenated ovalbumin (OVA), which is
degraded into fluorescent peptides by the action of intracellular proteases. Thus,
eosinophil expression of the surface molecules necessary for effective antigen
presentation was confirmed, as was their ability to process complex antigen. Further
investigations revealed that eosinophils can present complex OVA antigen to CD4+ T
lymphocytes obtained from the allergic mouse, and to in vitro derived OVA-specific
Th2 cells. In the presence of exogenous antigen, eosinophils co-cultured with T
lymphocytes were able to induce Th2 cytokine production, and demonstrated an ability
for eosinophils to modulate T lymphocyte function in vitro.¶
The ability for eosinophils to act as antigen presenting cells in vivo was also
investigated. Eosinophils obtained from the antigen-saturated lungs of OVA sensitised
and challenged mice were transferred to the peritoneal cavities of naïve host mice.
When subsequently challenged with aerosolised OVA, eosinophil recipients developed
a pulmonary eosinophilia similar to that of OVA sensitised and challenged mice. To
validate this finding, the experimental procedure was altered to accommodate the use of
non-allergy derived eosinophils, which were pulsed with OVA in vitro, prior to transfer
into naïve recipients. When subsequently challenged with aerosolised OVA, eosinophil
recipients developed a peripheral blood and pulmonary eosinophilia, and stimulation
with OVA induced IL-5 and IL-13 cytokine production from pulmonary draining lymph
node cells. Notably, the AAD induced by transfer of antigen pulsed eosinophils did not
induce detectable OVA-specific IgG1, which may be attributed to the lack of soluble
antigen required for B cell antibody production.¶
During the course of these investigations, an OVA T cell receptor (TCR) transgenic
mouse (OT-II) was procured with a view to defining the interaction between eosinophils
and activated T lymphocytes (Barnden et al., 1998). Despite having specificity for the
OVA323-339 peptide, an immunodominant epitope that skews naïve T cell responses
towards Th2 cytokine release (Janssen et al., 2000), T lymphocytes from the OT-II
mouse preferentially secreted IFN-γ in response to stimulation with either OVA peptide
or OVA. These mice were further characterised in a mouse model of AAD, and found to
be refractory to disease induction and progression, which may be attributed to
significant IFN-γ secretion by transgenic CD4+ T lymphocytes during antigen
sensitisation. Indeed, these cells were noted for their ability to attenuate pulmonary
eosinophilia when transferred to OVA sensitised and challenged wild type mice,
although serum OVA-specific IgG1, peripheral blood eosinophilia levels and airways
response to methacholine challenge remained intact.¶
Knowledge of the biased Th1 phenotype in naïve OT-II provided a unique opportunity
to investigate the fate of T lymphocytes bearing high affinity OVA-specific TCRs
following neonatal antigen exposure to soluble OVA. In a previous study, subcutaneous
(s.c.) administration of soluble OVA to wild type neonatal mice was suspected to have
deleted OVA-specific T cells from the T cell repertoire (Hogan et al., 1998a). Using
flow cytometry and TCR specific antibody, the delivery of s.c. OVA to OT-II neonates did not alter transgenic T cell populations in adult mice. Instead, it was surprising to
find a skewing towards the Th2 phenotype and loss of IFN-γ secretion following OVA
sensitisation and challenge in adult mice. A mechanism for this reprogramming of the
transgenic T cell from the Th1 to a Th2 phenotype following OT-II neonatal exposure
to soluble OVA is proposed, and further experimentation may validate this hypothesis.¶
In conclusion, eosinophils residing in the allergic lung have the capacity to interact with
activated T cells, both within this tissue and the draining lymph nodes. Despite their
relative inefficiency as antigen presenting cells (Mawhorter et al., 1994), eosinophils
may participate en masse in the serial triggering of activated TCRs, and provide
appropriate costimulatory signals that modulate T lymphocyte function. Through the
elaboration of Th2 cytokines and stimulation of T cell proliferation, antigen presenting
eosinophils may transiently prolong or exacerbate the symptoms of allergic diseases.
Alternatively, eosinophils presenting relevant antigens may inhibit T cell activity via
degranulation, and such activity has recently been observed in a parasite model (Shinkai
et al., 2002). Finally, experiments in the OT-II mouse have provided valuable
information to suggest that therapies designed to modulate eosinophil numbers in
allergic tissues through the secretion of opposing cytokines such as IFN-γ, may be of
limited benefit. The results shown here suggest that airways dysfunction remains intact
despite significantly reduced pulmonary eosinophilia
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Chabour, Ihssene. "1,3-Dipolar cycloadditions using catalysts with double chirality and novel multicomponent [4+2] processes." Doctoral thesis, Universidad de Alicante, 2021. http://hdl.handle.net/10045/114674.
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In this thesis, different cycloaddition reactions, such as the enantioselective 1,3-dipolar-cycloaddition, which takes place between in situ generated stabilized azomethine ylides, and electrophilic alkenes, and the diastereoselective multicomponent reactions Amine-Aldehyde-Dienophile (AAD) or Phosphoramidate-Aldehyde-Dienophile (PAD) are described. In Chapter 1, an asymmetric 1,3-dipolar cycloaddition reaction involving an imino ester with tert-butyl acrylate was carried out using a silver(I) complex with double chirality, formed from a chiral phosphoramidite and chiral silver binolphosphate(I). The goal of this reaction is to synthesize key enantiomerically enriched structures to access the GSK-third generation of HCV inhibitors. In Chapter 2, the synthesis of polysubstituted cyclohex-2-enylamines using the multicomponent Amine-Aldehyde-Dienophile reaction involving benzyl or 4-methoxybenzylamine, is described. The study the diastereoselective version, employing commercially available chiral benzylic amines, or even a maleimide with the chiral information at the nitrogen atom, are also reported. In Chapter 3, the synthesis of polysubstituted cyclohex-2-enylamines derivatives using the multicomponent Phosphoramidate-Aldehyde-Dienophile (PAD), is described. Several series of N-substituted phosphoramidates reacted with α,β-unsaturated aldehydes, bearing hydrogen atoms at the γ-position, in good yields.
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Karlsson, Cornelia, Azra Kljako, and Therése Pauldén. "Is Political Activism the New Black? : Consumers' Attitudes toward a Brand that uses Political Activism in Advertisement." Thesis, Linnéuniversitetet, Institutionen för marknadsföring (MF), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-65198.
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Background: In 2017, brands have started to use their advertisements to take stance in political issues. However, since this trend has emerged in 2017, research in the field is limited. The research that is available is focused on how attitudes toward advertisements in general affect consumer attitudes toward the brand, which calls for deeper knowledge on how the political activism trend affect consumers’ attitudes. Purpose: To explore how political activism in advertisements affect consumers’ attitudes toward the brand behind the advertisement. Research Question: How does political activism in advertisements affect consumers’ attitudes toward the brand? Methodology: This study is of qualitative nature and took an explorative approach. Data was collected through semi-structured interviews based on a convenience sample of 11 respondents. Conclusion: The main findings from this study was that political activism in advertisement had an enhancing affect on respondents’ attitudes toward the brand behind the advertisement. Respondents that had positive attitudes toward the brand before were more positive toward the brand after the political advertisement, while the ones who were negative became more negative after the political advertisement. Keywords Political activism, attitudes toward advertisements (Aad), attitudes toward brands (Ab), incongruity and involvement.
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Sims-Cutler, Kristin M. "The General Abilities Index as a Third Method of Diagnosing Specific Learning Disabilities." ScholarWorks, 2014. https://scholarworks.waldenu.edu/dissertations/403.
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Many studies have investigated problems with the ability achievement discrepancy (AAD) method of diagnosing specific learning disabilities (SLDs). The definition of an SLD includes the presence of a deficit in one or more cognitive processing systems. Researchers in other studies found that the AAD method overdiagnoses English language learners and students from low socioeconomic backgrounds, and underdiagnoses students with cognitive processing deficits. Although SLD diagnostic methods have been widely researched, much less information is available regarding SLD diagnostic methods that predict important student outcomes, such as high school completion. The General Abilities Index (GAI) is an SLD diagnostic method that can identify cognitive processing deficits. This study examined the relationships between cognitive processing deficits and the GAI method, high school completion status, performance on state standards assessments, and SLD eligibility. Using a multivariate, nonexperimental design, this study analyzed 149 datasets from records of students tested for an SLD between 1996 to 2013. A GLM analysis found that several types of cognitive processing deficits predicted math and writing performance on the state standards assessment and predicted not being diagnosed with an SLD, while the GAI method failed to predict any relationship with the dependent variables. Positive social changes from this study may include improved SLD diagnostic practices and improved educational interventions that target the cognitive processing deficits. Improved educational outcomes for SLD persons may reduce the high rates of unemployment, substance abuse, and incarceration experienced by the adult SLD population.
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Adil, Safaa. "Influence de la présence d’un personnage, d’un visage et de la direction du regard en communication publicitaire." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1G025.
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Cette recherche a pour objectif d’examiner l’influence de la présence, dans des annonces presse, d’un personnage, d’un visage ou de la direction d’un regard sur l’attention portée à cette annonce ainsi que sur la mémorisation et les évaluations de cette annonce. Afin d’éprouver nos hypothèses quatre expérimentations ont été menées. Dans l’une d’entre elles un système eye-tracking a été utilisé permettant de mieux cerner les processus attentionnels. Pour nous rapprocher des conditions d’exposition habituelles à la publicité, les annonces presse ont été dissimulées dans un magazine fictif. Les résultats obtenus montrent que la présence du personnage ou du visage (versus leur absence), ainsi que le regard dirigé vers le produit (versus le regard dirigé vers l’observateur), exercent une influence sur l’attention portée à l’annonce, la mémorisation de son contenu et son évaluationThis research aims to examine the influence of the presence in a print advertisement of a character, a face or a gaze direction (gaze directed toward the product versus gaze directed toward the observer) on attention toward the advertisement, the memorization and the evaluation of the advertisement content. To test our hypotheses, four experiments were conducted. In one of these experiments an eye-tracker has been used to better measure attentional processes. In order to approach the ordinary conditions of exposure to advertising, print advertisements were inserted in a fictive magazine (folder test procedure). The results show that the presence of the character or the face (versus their absence) and the gaze directed toward the product (versus gaze directed toward the observer) improve the attention toward the advertisement, the memorization and the assessment of advertisement content
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Calero, M. "Novel gene therapy strategies for ADA deficiency using AAV vectors or gene editing." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1563615/.
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Debiasi, Clayton. "Efeitos de antiauxinas sobre a dominância apical em gemas de bananeira in vitro Cvs. grand naine (AAA), nanição (AAA) e enxerto (AAB)." Florianópolis, SC, 2000. http://repositorio.ufsc.br/xmlui/handle/123456789/78397.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias.Made available in DSpace on 2012-10-17T13:49:28Z (GMT). No. of bitstreams: 0
O presente trabalho evidenciou a influência da fonte de explante sobre o comportamento posterior do cultivo in vitro de bananeira e também dos fitorreguladores e antiauxinas sobre a liberação e/ou diminuição da dominância apical in vitro. A utilização de gemas apicais oriundas de plantas matrizes com graus de baixa e média dominância apical resultou nas maiores médias de brotos formados ao final de 5 subcultivos, com 141,76 e 143,96 brotos para as cvs. Grand Naine e Nanicão, respectivamente. A suplementação do meio de proliferação MS com BAP (11,1 mmol/l) resultou nas maiores médias de brotos formados ao final de seis subcultivos, com um total de 620,43, 785,96 e 224,97 brotos para as cvs. Grand Naine, Nanicão e Enxerto, respectivamente. Suplementando o meio com TDZ (0,090 mmol/l) e TIBA (0,019 mmol/l) obteve-se taxas proliferativas significativas e índices baixíssimos de variantes somaclonaias quando comparamos ao meio suplementado com BAP (11,1 mmol/l). As análises enzimáticas da AIA-Oxidase em rizomas de bananeira (cv. Grand Naine) revelaram que culturas mantidas em meio de proliferação MS, suplementado com BAP (11,1 mmol/l) ocorreu uma destruição crescente de AIA na região basal até o terceiro dia e quando o meio de cultura foi suplementado com BAP (4,44 mmol/l) e TIBA (0,019 mmol/l) ou BAP (4,44 mmol/l) e PCIB (46,7mmol/l) ocorreu uma redução do AIA destruído até o quinto e sexto dias na região basal em função das antiauxinas contidas no meio. As maiores médias de brotos adventícios formados por túberas cultivadas in vitro ocorreram em meios de proliferação MS, suplementados com BAP (11,1 mmol/l) ou TDZ (0,090 mmol/l) e TIBA (0,019 mmol/l), resultando em valores médios de 4,60 e 5,30 para a cv. Grand Naine, 2,00 e 6,50 para cv. Nanicão e 2,25 e 1,50 para cv. Enxerto, para os respectivos tratamentos.
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Decker, Cole R. "Brand personality, congruency, and net promoter score: A university case study." Ohio University Honors Tutorial College / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1460375965.
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Westraat, Andries Petrus. "Die aard en omvang van stres onder personeel verbonde aan die Suid-Afrikaanse Polisiediens Honde-eenheid in Durban /." Thesis, Pretoria : [s.n.], 2002. http://upetd.up.ac.za/thesis/available/etd-09102003-160104.
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Gorsline, Alana. "Detestable A.D." Diss., Online access via UMI:, 2005.
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Ogor, Robert. "Spécification opérationnelle en ADA d'un noyau pour le langage ADA." Rennes 1, 1985. http://www.theses.fr/1985REN10012.
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Abd, Tarish Samar Verfasser], Yong [Akademischer Betreuer] Lei, Martin [Gutachter] [Hoffmann, and Zhijie [Gutachter] Wang. "Construction of ZnO/ZnS core/shell nanotube arrays on AAO templates and relevant applications / Samar Abd Tarish ; Gutachter: Martin Hoffmann, Zhijie Wang ; Betreuer: Yong Lei." Ilmenau : TU Ilmenau, 2017. http://d-nb.info/1178145077/34.
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Abd, Tarish Samar Verfasser], Yong [Akademischer Betreuer] [Lei, Martin [Gutachter] Hoffmann, and Zhijie [Gutachter] Wang. "Construction of ZnO/ZnS core/shell nanotube arrays on AAO templates and relevant applications / Samar Abd Tarish ; Gutachter: Martin Hoffmann, Zhijie Wang ; Betreuer: Yong Lei." Ilmenau : TU Ilmenau, 2017. http://d-nb.info/1178145077/34.
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Kramar, A. "Augusta Ada Byron." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/40415.
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Augusta Ada Byron was born 10 December 1815 as the only
child of the poet Lord Byron and his wife Anne Isabella Byron.
Byron did not have a relationship with his daughter.Ada was often
ill, beginning in early childhood. At the age of eight, she experienced
headaches that obscured her vision. In June 1829, she was paralyzed
after a bout of measles. She was subjected to continuous bed rest for
nearly a year. By 1831, she was able to walk with crutches. Despite
being ill Ada developed her mathematical and technological skills.
At age 12, this future "Lady Fairy", as Charles Babbage
affectionately called her, decided she wanted to fly. Ada went about
the project methodically, thoughtfully, with imagination and passion
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Laurent, Christina Kae. "Interpreting the ADA." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/271609.
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The Americans with Disabilities Act (ADA) is something that has created both freedom and confusion. There are those who are affected by the law, have family members who are, or have a basic understanding of the law. These varying degrees of knowledge help play a part in the confusion surrounding the law. Add to that the fact that the ADA is constantly being amended and it is no wonder that misunderstanding ensues. This paper sets out to see where the disorientation of the ADA is taking place, why it is happening, and what can be done to change it. Interpreting this law can seem like an insurmountable feat but to comprehend the law, its history must first be understood. It is important to distinguish between the law and the people it protects. They are not mutually exclusive or inclusive.
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Klomp, Martinus. "Hulpverlening aan adolescenten een bijdrage aan methodiekontwikkeling in Trainingscentra voor Kamerbewoning /." [S.l. : Groningen : s.n.] ; University Library Groningen [Host], 1992. http://irs.ub.rug.nl/ppn/12463835X.
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DeLooze, Lori L. "ITS Ada : an intelligent tutoring system for the Ada programming language." Thesis, Monterey, California. Naval Postgraduate School, 1991. http://hdl.handle.net/10945/28322.
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Kumar, Arbind. "Credit system in early medieval India (c. 650 A.D.-1200 A.D.) /." New Delhi : Commonwealth Publishers, 1992. http://catalogue.bnf.fr/ark:/12148/cb40161438x.
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Abd, Al-Rahman D. S. "A critical edition of Kitab Sharaf Al-Mustafa by Abu Sa'd Abd al-Malik b. Abi Uthman b. Muhammad al-Kharkushi : Died 407 A.H./1016 A.D." Thesis, University of Exeter, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374921.
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Aissa, Larousse Jameleddine. "Etude de la variabilité génétique des régions NS3, NS5A et NS5B du virus de l'hépatite C chez des patients Tunisiens non traités." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0434/document.
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Introduction : Le virus de l’hépatite C (VHC), est l’une des premières causes de pathologie hépatique dans le monde. Ce virus à ARN est responsable de l’hépatite C qui aboutit au développement de la cirrhose et du cancer du foie. Selon l’Organisation Mondiale de la Santé, le VHC infecte actuellement plus de 170 millions de personnes dans le monde, soit 3% de la population. L’hépatite C chronique connait toujours en Tunisie un taux de guérison faible pour le génotype 1 car le traitement standard actuellement disponible est la bithérapie interféron pégylé associé à la ribavirine. A l’heure actuelle, le développement de différentes molécules ciblant spécifiquement le VHC, appelées les antiviraux à action directe (AAD), apparait comme une potentielle révolution dans le traitement de l’infection par le VHC.Ces AAD comprennent les inhibiteurs de protéase (IP), les inhibiteurs nucléos(t)idiques (IN) et les inhibiteurs non-nucléosidiques (INN) de la polymérase NS5B ainsi que les inhibiteurs de la protéine NS5A. La quasi-espèce virale est formée d’un mélange complexe de variants viraux parmi lesquels se trouvent des variants associés à des degrés variables à la résistance aux AAD. Ces variants peuvent donc exister naturellement en absence de toute pression médicamenteuse et sont susceptibles d’avoir un impact sur la réponse aux différents traitements par AAD. Notre objectif était de déterminer la prévalence des variants associés à la résistance dans les souches tunisiennes circulantes en préambule à l’introduction deces molécules en Tunisie. Méthodes : L’amplification et le séquençage direct de la protéase NS3, de la polymérase NS5B ainsi que la région NS5A ont été effectuées chez 149 patients tunisiens naïfs de traitement et infectés par le VHC de génotype 1 (génotype 1b = 142 ; génotype 1a = 7). Résultats : Douze séquences NS3 (12/131 ; 9,2%) ont montré des mutations connes pour conférer une résistance aux IP. Une seule séquence (1/95 ; 1,1%) a montré la mutation V321I connue pour conférer une résistance aux IN-NS5B. Trente quatre séquences (34/95 ; 35,8%) ont montré des mutations connues pour diminuer la sensibilité des INN-NS5B. Une seule séquence de génotype 1a (1/7 ; 14,3%) et 17 séquences de génotype 1b (17/112 ; 16,2%) ont montré des mutations connues pour conférer une résistance au inhibiteurs de la protéine NS5A. Conclusions : Notre étude a permis de mettre en évidence la présence de substitutions conférant une diminution de la sensibilité aux AAD chez des patients tunisiens naïfs de tout traitement anti-VHC. Des études in situ seront nécessaires pour évaluer l’impact de ces mutations sur la réponse au traitementIntroduction: Hepatitis C virus (HCV) is a major cause of liver disease worldwide. This RNA virus is responsible for hepatitis C, which leads to the development of cirrhosis and liver cancer. According to the World Health Organization, HCV infects more than 170 million people worldwide, about 3% of the population. Chronic hepatitis C still know in Tunisia low cure rates for genotype 1, because the currently standard treatment available is combination therapy of pegylated interferon plus ribavirin. At present, the development of different molecules that specifically target HCV, called direct-acting antivirals (DAA) appears as a potential revolution in the treatment of HCV infection. These DAA include protease inhibitors (PI), nucleos(t)ide (NI) and non-nucleoside inhibitors (NNI) for NS5B polymerase and NS5A inhibitors. The viral quasispecies is formed by a complex mixture of viral variants including variants associated with variable degrees of resistance to DAA. These variants may therefore exist naturally in absence of drug pressure and may affect response to different treatments by DAA. Our objective was to determine the prevalence of variants associated with resistance in circulating Tunisian strains preamble to the introduction of these molecules in Tunisia. Methods: Amplification and direct sequencing of NS3 protease, NS5B polymerase and NS5A region were performed in 149 Tunisian naïve patients infected with HCV genotype 1 (genotype 1b = 142; genotype 1a = 7) . Results: Twelve sequences NS3 (12/131; 9.2%) showed mutations known to confer resistance to PI. One sequence (1/95; 1.1%) showed the V321I mutation known to confer resistance to NS5B-IN. Thirty four sequences (34/95; 35.8%) showed mutations known to reduce the sensitivity of NS5B-INN. One genotype 1a sequence (1/7; 14.3%) and 17 genotype 1b sequences (17/112; 16.2%) showed mutations known to confer resistance to NS5A inhibitors.Conclusions: Our study highlighted the presence of substitutions conferring decreased susceptibility to DAA in naïve patients infected with HCV genotype 1. Field studies will be needed to evaluate the impact of these mutations on the treatment response
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Wong, Hoi To, and 黃海濤. "A study of Jingzhou region during the Southerndynasties (420 A.D.-589 A.D.)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31228392.
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Zaidan, Humberto Actis. "Níveis de Putrescina, Poliaminas e Nutrientes Minerais Relacionados a Diferentes Concentrações de Potássio em Bananeira (Musa sp., AAA e AAB) cvs. Nanica e Prata Anã in Vitro." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/11/11144/tde-28122004-202448/.
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Nas abordagens biotecnológicas de propagação de plantas, os meios de cultura devem ter uma composição química adequada à essa finalidade permitindo a otimização da produção. Como a bananeira (Musa sp.) é exigente em potássio, a busca do nível adequado desse macronutriente envolve não somente o comprometimento com o nível dos outros nutrientes (balanço iônico), mas também a relação entre eles. Para acompanhar os efeitos fisiológicos das relações de vários teores de K com os outros macro e micronutrientes é que explantes caulinares dos cvs. Nanica e Prata Anã foram cultivados em meio MS modificado em presença de BAP, sacarose, vitaminas, agar, suplementado com 6 diferentes doses de K: 5, 10, 15, 20, 25 e 30 mM, sendo que a dose 20 mM corresponde à concentração de K existente no MS básico, que foi adotado como controle.Foram feitas análises de massa de matéria seca (MMS),macro e micronutrientes na parte aérea, raiz e plântulas inteiras. Ao final do experimento foi determinado o número de plântulas e calculado o valor das relações N/K, K/P, K/Ca, K/Mg, K/Ca+Mg, K/S, K/Cu, K/Fe, K/Mn, K/Zn.Foram também dosados os teores da diamina putrescina e de poliaminas, e calculada a relação K/putrescina. Todos os parâmetros foram analisados segundo um delineamento experimental inteiramente casualizado. As plântulas que se desenvolveram em baixas concentrações de K apresentaram sintomas visuais de deficiência, como clorose e necrose das folhas mais velhas. Os cultivares apresentaram diferenças quantitativas entre si tanto em relação aos valores de MMS como em número de plântulas, relacionados às doses de K presentes nos meios de cultura. Em ambos os cultivares foi observada uma relação direta entre o desenvolvimento das plântulas e as concentrações de K com otimização ao redor de K 15 a 20 mM. Os teores de putrescina e de poliaminas foram maiores nos níveis mais baixos de K, atingindo o máximo na dose de K 5 mM. Em K 20 mM ocorreram maiores valores de MMS e em K 15 mM maior número de plântulas regeneradas. O íon K em geral foi mais intensamente absorvido do que os outros macro e micronutrientes sendo que estes tiveram sua absorção diminuída devido provavelmente a um efeito de diluição de seus teores pelo crescimento das plântulas in vitro. Esses resultados, inclusive os obtidos nas demais relações entre K e os outros macro e micronutrientes, as quais sempre foram crescentes (de K 5 a 30 mM), corroboram a essencialidade desse nutriente para os cvs. Nanica e Prata Anã.Potassium is required in high dosis by the banana plant (Musa sp.) and interacts with other macro and micronutrients present in the medium in which banana tissues are maintained in vitro condition,with consequent modifications in the plant cell metabolism, mainly in nitrogen compounds, such as proteins and amino acids. When K is present in concentrations lower than the required, diamines such as putrescine, and polyamines, such as spermidine and spermine are formed. In order to establish the best dosis of K and follow the physiological consequences of the relationships N/K, K/P, K/Ca, K/Mg, K/Ca+Mg, K/S, K/Cu, K/Fe, K/Mn, K/Zn and K/putrescine, shoot apex of two banana cvs. Nanica and Prata Anã were maintained in asseptic conditions in modified MS media in the presence of 6 different dosis of K: 5, 10, 15, 20, 25 and 30 mM, K 20 mM being the K concentration in basic MS medium, and then transferred to rooting media with the same different K dosis. Dry wt., macro and micronutrients were measured in the shoots, roots and the intire plantlet, and number of plantlets produced determined, the data being analysed estatistically. Putrescine and polyamines were also determined. Visual symptoms of K deficiency such as clorosis and necrosis in the older leaves of all plantlets under low dosis of K were observed. The levels of putrescine and polyamines increased as K decreased in the medium, reaching the maximum value at K 5 mM, both cultivars presenting similar bahavior in relation to the diamine in some K concentrations. Quantitative differences were obtained among the two cultivars pertained to dry wt. values, number of in vitro regenerated banana plantlets and K concentration with optimization around K 15 and 20 mM. In general K absorption was more intense than the other nutrients, the absorption of the later being decreased probably due to a dilution effect of their values as the banana plantlets developed in vitro. These results, including those pertained to the relationships between K and the other nutrients, which always were high (from K 5 to 30 mM), corroborate the importance of potassium ion to the banana cvs. Nanica and Prata Anã.
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Jansson, Björn, and Sebastian Maghsoudi. "Developing SharePoint add-ins." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136719.
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Developing a Microsoft SharePoint-based site is, according to marketing, simple and efficient. Efficiency is increased by giving the developer the option to easily add functionality to the site. One way to add functionality is through so called add-ins. An add-in extends the functionality of the site by running independent code on the client, cloud or a server outside the SharePoint farm. Add-ins can be added to the site through a web-based market or by creating new ones. The general question is if creation of new add-ins is worth the effort. This discussion can begin by investigating what implementation detail is reoccurring when developing this add-ins as well as what part of the process the most time is consuming. By attempting to create add-ins and the same time documenting the progress one can make conclusion regarding said questions. The result shows that the most recurring parts of development is how to manage the incoming data. It also seems as if the most time consuming part of add-in development is the research and construction of functionality that fetch data from the SharePoint-based site. Another part of the result is technical and contains information necessary to understand how the example add-ins are created. The add- ins that is presented in this paper concern document management which is a significant aspect of Microsoft SharePoint.
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Saris, Wim H. M. "Sleutelen aan de voeding." Maastricht : Maastricht : Maastricht University ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=12897.
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Duvenage, J. B. "Riglyne aan die entrepreneur." Interim : Interdisciplinary Journal, Vol 4, Issue 1: Central University of Technology, Free State, Bloemfontein, 2005. http://hdl.handle.net/11462/423.
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Published ArticleThe concept entrepreneurship can be defined as the ordinary individual who does extraordinary things which other ordinary individuals hesitate to do. The act of doing is a distinctive element of the entrepreneur. Considering the level of unemployment, the shortage of housing, uneven distributions of wealth and income, low level of education and high population growth rate in South Africa, the entrepreneur can play a major role. Entrepreneurs must equip themselves with knowledge, skills and the right attitude. In this article the focus is on various entrepreneurs to understand the world of entrepreneurship better.
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Djurdjevic, Smilja. "New AAA-DDD heterocomplexes." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/13661.
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The basis of this project was to synthesise novel aromatic heterocyclic hosts, with two and three adjacent hydrogen bond acceptor (A) sites in AA and AAA arrangements. In order to produce the targeted systems, new synthetic methods and techniques such as flash vacuum pyrolysis (FVP), Buchwald-Hartwig-coupling and Suzuki coupling chemistry, etc. were employed. The purpose of this investigation was to study the binding affinity of the AA and AAA units with donors (D) in AA-DDD and AAA-DDD heterocomplexes. The FVP approach allowed the synthesis of naphthydrine ring systems in only two steps from substituted Meldrum’s acid derivatives after cyclisations at high temperature. In the second approach palladium catalyzed coupling was used to provide heterocyclic diarylamines from readily available pyridine or naphthyridine precursors, with subsequent ring closure under acidic conditions. This approach led to the synthesis of new compounds: dipyrido[1,2-a;2’, 3’-a]pyrimidin-5-one (AA) and 1,6a,11,12-tetraaza-naphthacene-6-one (an AAA hydrogen bonding unit) in high yields. The Suzuki coupling strategy afforded compounds: dibenzo[c,f][1,8]naphthyridine 6 (AA) and 1,13,14-triazadibenz[a,j]anthracene (AAA); their extended aromatic framework is thought to help overcome stability problems during binding studies. For the binding studies, the selected DDD counterparts were dihydropyridines 2,6-bis(hydroxyl-methyl)-p-cresol and protonated 2,6-diaminopyridine (with a lipophylic tetraarylborate counter-ion) developed as a cationic DDD unit. The extremely high binding stability of all these heterocomplexes is attributed to the combination of cooperative secondary interactions and strong electrostatic energy.
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Stanczyk, Christine M. (Christine Mary) Carleton University Dissertation Information and Systems Science. "MLog to Ada transformations." Ottawa, 1989.
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Abd-el-Salehin, Abd-el-Aziz Ali Abd-el-Latif [Verfasser]. "Model electrodes for the electrooxidation of simple alcohols : a DEMS study / Abd-el-Aziz Ali Abd-el-Latif Abd-el-Salehin." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1016022654/34.
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Hartmann, Britta. "Aller Anfang : zur Initialphase des Spielfilms /." Marburg : Schüren, 2009. http://www.schueren-verlag.de/?aid=2393.
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Bieberstein, Rada. "Lost diva - found woman : female representations in new Italian cinema and national television between 1995 and 2005 /." Marburg : Schüren, 2009. http://www.schueren-verlag.de/?aid=2397.
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Aping, Norbert. "Laurel und Hardy auf dem Atoll : auf den Spuren von Laurel und Hardys letztem Spielfilm /." Marburg : Schüren, 2007. http://www.schueren-verlag.de/?aid=1713.
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Horbrügger, Anja. "Aufbruch zur Kontinuität - Kontinuität im Aufbruch : Geschlechterkonstruktionen im west- und ostdeutschen Nachkriegsfilm von 1945 bis 1952." Marburg Schüren, 2007. http://www.schueren-verlag.de/?aid=1723.
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Mädler, Kathrin. "Broken Men : sentimentale Melodramen der Männlichkeit - Krisen von Gender und Genre im zeitgenössischen Hollywood-Film /." Marburg : Schüren, 2008. http://www.schueren-verlag.de/?aid=1969.
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Frisch, Simon. "Mythos Nouvelle Vague : wie das Kino in Frankreich neu erfunden wurde /." Marburg : Schüren, 2007. http://www.schueren-verlag.de/?aid=1841.
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Martig, Charles. "Kino der Irritation : Lars von Triers theologische und ästhetische Herausforderung /." Marburg : Schüren Verl, 2008. http://www.schueren-verlag.de/?aid=1846.
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Bühler, Kathleen. "Autobiografie als Performance. Die Experimentalfilme Carolee Schneemanns /." Marburg : Schüren Verlag GmbH, 2009. http://www.schueren-verlag.de/?aid=2114.
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Heger, Christian. "Die rechte und die linke Hand der Parodie : Bud Spencer, Terence Hill und ihre Filme /." Marburg : Schüren Verlag, 2009. http://www.schueren-verlag.de/?aid=2383.
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Lostal, William. "Approches thérapeutiques pour le traitement des dysferlinopathies." Thesis, Evry-Val d'Essonne, 2010. http://www.theses.fr/2010EVRY0009/document.
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Ce travail de thèse a porté sur le développement d'approches thérapeutiques pour les dysferlinopathies, pathologies dues à un déficit en dysferline, pour lesquelle sil n'existe pas de traitement à l'heure actuelle. Nous avons généré et caractérisé un modèle murin déficient en dysferline, B6.A/J-Dysfprmd, pouvant être comparé avec une souche contrôle. Ce modèle présente une atteinte dystrophique dès deux mois et une diminution de l'activité locomotrice est mise en évidence. Dans une approche par transfert de gène dans le muscle, compte-tenu de la taille de l’ADNc de la dysferline, nous avons utilisé la capacité à se concatémériser des vecteurs AAV. Les résultats ont montré une expression stable d’une protéine entière, jusqu’ à au moins un an. Cette expression est associée à une amélioration fonctionnelle et phénotypique des animaux traités. Une autre étude a porté sur l’évaluation du potentiel thérapeutique d’une forme courte de dysferline. Les résultats ont montré qu’une protéine tronquée était exprimée et permet une restauration partielle de la fonction de réparation membranaire, mais aucune amélioration phénotypique n’est détectée. Ces résultats suggèrent pour la première fois, une modularité de la dysferline. Finalement, nous avons testé si un déficit en dysferline pouvait être compensé par la surexpression de myoferline. Un modèle murin surexprimant la myoferline a été créé. Celui-ci ne montre pas de signes délétères dus à cette surexpression. Ces souris transgéniques ont ensuite été croisées avec les souris déficientes en dysferline. Une amélioration de la fonction de réparation membranaire est observée, mais le phénotype dystrophique du muscle n’est pas amélioréIn this work, I developed and studied therapeutical strategies for dysferlinopathies, neuromuscular disorders due to dysferlin deficiency. To date, no treatment is available for these diseases. We generated and characterized a dysferlin deficient mouse model, B6.A/J-Dysfprmd. The onset begins at 2-month old with an associated decrease of locomotor activity. For gene transfer approach into muscle, dysferlin coding sequence is too large to enter into a single rAAV. We used properties of rAAV to concatemerize by ITR sequences interaction. Results, obtained with this strategy, showed expression of entire dysferline protein until at least one year. We showed also that this expression is associated to an improvement of phenotype and functional activity of tretaed mice. We also studied therapeutical potential of a truncated dysferlin protein. Results showed the expression of a short protein cassociated to a partial functional membrane repair activity, but none in locomotor activity. Nonetheless, these results showed for the first time a partial modularity of dysferlin. Finally, we also studied compensation of dysferlin by myoferlin overexpression in muscle. A myoferlin-overexpressing transgenic mouse model was generated; a significant level of myoferlin is detected but no deleterious effect was observed. These transgenic mice were crossed with dysferlin deficient mice. An improvement of membrane repair capacity is observed, nevertheless, dystrophic features into muscle were still present
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Palma-Amalric, Valérie. "L'autonomie financière des autorités indépendantes : contribution à la notion d'autonomie financière en droit public." Thesis, Toulouse 1, 2014. http://www.theses.fr/2014TOU10058.
Full textAbstract:
L’autonomie financière des autorités indépendantes (AI) est à la fois la plus primordiale et la plus incertaine de leurs qualités. Elle n’est certes pas totale, mais elle existe et se mesure au moyen de critères et indices variés. Celle-ci se compose notamment de deux éléments : l’autonomie budgétaire, constituée par la liberté dans la définition du budget et notamment dans l’attribution des ressources, et l’autonomie de gestion comptable et financière, caractérisée par le libre emploi des crédits et donc la maîtrise de la dépense. Or, les AI étant enserrées dans des liens de dépendance vis-à-vis de l’Etat, il convient de se demander comment s’articulent de tels liens avec l’autonomie financière des AI. L’autonomie financière mesurée au sein des autorités administratives indépendantes étant perfectible, il convient de la préserver et de l’assurer au moyen d’une protection juridique concrète et effective se manifestant par la mise en place de particularismes éloignant voire détachant les AAI du système financier de droit commun régis par la LOLFThe financial autonomy of independent authorities (IA) is at the same time the most crucial, yet uncertain characteristic of these authorities. Although not full, this autonomy does exist and can be measured through several yardsticks. Autonomy encompasses two elements : on the one hand, fiscal autonomy, consisting in the capacity to freely define the budget, notably by deciding on the allocation of resources and, on the other hand, accounting autonomy, allowing for the free use of payment appropriations and, thus, expenditure control. However, independent authorities being enclosed in relationships of dependence with the state, that’s why we can ask us how articulate these links with the financial autonomy of IA.The financial autonomy that is measured in the independent administrative authorities can beimproved. One should preserve it and guarantee it by means of a concrete and effective legalprotection through the setting up of specificities setting apart independent administrativeauthorities from the general law of the financial system, where the LOLF is applicable
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Maschio, Laura Cristina de Oliveira. "Estudo da distribuição de íons e metais em sangue via metodologia nuclear." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-11062008-095329/.
Full textAbstract:
O presente estudo consiste na utilização de ferramentas nucleares com o intuito de fornecer um procedimento alternativo para realização de análises bioquímicas em sangue que possam auxiliar no diagnóstico de patologias diversas. O objetivo é medir a ocorrência de metais e íons em sangue total de humanos, via ativação neutrônica, disponibilizando os limites de normalidade bem como as correlações entre eles. Para realização deste estudo 283 amostras de sangue total foram analisadas (doadas de indivíduos selecionados em bancos de sangue) obtendo-se os limites de normalidade para: Br (0,0067 - 0,0263 gl-1), Cl (2,54 - 3,50 gl-1), K (1,33 - 1,89 gl-1) e Na (1,48 - 2,06 gl-1). Esses dados constituem as primeiras estimativas realistas para valor de referência em sangue total da população brasileira. Esses limites foram avaliados em função do sexo e idade permitindo salientar as diferenças biológicas. Os limites obtidos para Br, Cl, K e Na foram avaliados também entre diferentes populações, isto é, para duas regiões distintas: Sudeste (coleta realizada na cidade de São Paulo) e Nordeste (coleta realizada na cidade de Recife), locais escolhidos em função das similaridades (cidades de grande porte e industrializadas). Adicionalmente, foi realizado um estudo sistemático desses limites, no período de 4 (quatro) anos, na cidade de São Paulo; para esta finalidade a coleta foi realizada em função do tempo, dada a necessidade de atualização desses dados, pois esses elementos atuam como monitores ambientais. Estimativas para Ca e Fe foram também propostas para um conjunto de 22 amostras de sangue total.The present study consists of using nuclear tools aiming to establish an alternative procedure to perform biochemistry analyses in whole blood to help the diagnosis of diverses pathologies. The aim is to determine the íons and metals concentrations in whole blood of human beings (specifically: Br, Cl, K e Na), using neutron activation analysis, providing the limits of normality, as well as, the matrix of the correlation for these elements. To perform this study, 283 samples of whole blood had been analyzed (of healthy volunteers selected from blood banks), resulting in the limits of normality for Br (0.0067 - 0.0263 gl-1), Cl (2.54 - 3.50 gl-1), K (1.33 - 1.89 gl-1) and Na (1.48 - 2.06 gl-1). These data are the first estimates for reference values in whole blood of the Brazilian population. These limits were evaluated in function of the sex and age for checking the biological differences. The behavior of these limits was also evaluated for different populations, i.e., in two distinct regions: Southeast (blood collection carried out in São Paulo city) and Northeast (blood collection carried out in Recife city). These places were chosen in function of the similarities (cities with high concentration people and industrialized). Futhermorer, a systematic study of these limits was also evaluated, in the period of 4 (four) years, in São Paulo city. This analysis was elaborated in function of time due the necessity to update these data, therefore they act as monitorial ambient. The estimation for Ca and Fe were also proposal for a set of 22 samples of whole blood.