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Relevant bibliographies by topics / A9 neurons

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Academic literature on the topic 'A9 neurons'

Author: Grafiati

Published: 14 March 2023

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Journal articles on the topic "A9 neurons"

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Haynes, John M., Shanti M. Sibuea, Alita A. Aguiar, Fangwei Li, Joan K. Ho, and Colin W. Pouton. "Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson’s disease." PLOS ONE 16, no. 12 (December 23, 2021): e0261730. http://dx.doi.org/10.1371/journal.pone.0261730.

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In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced expression of markers of an A9 mDA phenotype (KCNJ6, ALDH1A1 and TH) but increased expression of the transcriptional repressors NR0B1 and NR0B2. Overexpression of NR0B1 and or NR0B2 promoted a loss of A9 dopaminergic neuron phenotype markers (KCNJ6, ALDH1A1 and TH). Overexpression of NR0B1, but not NR0B2 promoted a reduction in expression of the β-catenin-dependent WNT signalling pathway activator RSPO2. Analysis of Parkinson’s disease (PD) transcriptomic databases shows a profound PD-associated elevation of NR0B1 as well as reduced transcript for RSPO2. We conclude that reduced β-catenin-dependent WNT signalling impacts dopaminergic neuron identity, in vitro, through increased expression of the transcriptional repressor, NR0B1. We also speculate that dopaminergic neuron regulatory mechanisms may be perturbed in PD and that this may have an impact upon both existing nigral neurons and also neural progenitors transplanted as PD therapy.

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Fiorenzano, Alessandro, Edoardo Sozzi, Malin Parmar, and Petter Storm. "Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing." Cells 10, no. 6 (June 1, 2021): 1366. http://dx.doi.org/10.3390/cells10061366.

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Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets. The A9 DA neuron subtype controls motor function and is primarily degenerated in Parkinson’s disease (PD), whereas A10 neurons are largely unaffected by the condition, and their dysfunction is associated with neuropsychiatric disorders. Currently, DA neurons can only be reliably classified on the basis of topographical features, including anatomical location in the midbrain and projection targets in the forebrain. No systematic molecular classification at the genome-wide level has been proposed to date. Although many years of scientific efforts in embryonic and adult mouse brain have positioned us to better understand the complexity of DA neuron biology, many biological phenomena specific to humans are not amenable to being reproduced in animal models. The establishment of human cell-based systems combined with advanced computational single-cell transcriptomics holds great promise for decoding the mechanisms underlying maturation and diversification of human DA neurons, and linking their molecular heterogeneity to functions in the midbrain. Human pluripotent stem cells have emerged as a useful tool to recapitulate key molecular features of mature DA neuron subtypes. Here, we review some of the most recent advances and discuss the current challenges in using stem cells, to model human DA biology. We also describe how single cell RNA sequencing may provide key insights into the molecular programs driving DA progenitor specification into mature DA neuron subtypes. Exploiting the state-of-the-art approaches will lead to a better understanding of stem cell-derived DA neurons and their use in disease modeling and regenerative medicine.

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GRENHOFF, J., L. UGEDO, and T. H. SVENSSON. "Firing patterns of midbrain dopamine neurons: differences between A9 and A10 cells." Acta Physiologica Scandinavica 134, no. 1 (September 1988): 127–32. http://dx.doi.org/10.1111/j.1748-1716.1988.tb08468.x.

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Pujo, J., G. De Palma, J. Lu, S. M. Collins, and P. Bercik. "A9 DORSAL ROOT GANGLIA NEURONAL RESPONSES AND SUBSTANCE P PRODUCTION ARE HIGHER IN MALE MICE." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (March 1, 2021): 10–11. http://dx.doi.org/10.1093/jcag/gwab002.008.

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Abstract Background Abdominal pain is a common complaint in patients with chronic gastrointestinal disorders. Accumulating evidence suggests that gut microbiota is an important determinant of gut function, including visceral sensitivity. Germ-free (GF) mice have been shown to display visceral hypersensitivity, which normalizes after colonization. Sex also appears to play a key role in visceral sensitivity, as women report more abdominal pain than men. Thus, both gut bacteria and sex are important in the regulation of gut nociception, but the underlying mechanisms remain poorly understood. Aims To investigate the role of gut microbiota and sex in abdominal pain. Methods We used primary cultures of sensory neurons from dorsal root ganglia (DRG) of female and male conventionally raised (SPF) or germ-free (GF) mice (7–18 weeks old). To study the visceral afferent activity in vitro, calcium mobilization in DRG sensory neurons was measured by inverted fluorescence microscope using a fluorescent calcium probe Fluo-4 (1mM). Two parameters were considered i) the percentage of responding neurons ii) the intensity of the neuronal response. First, DRG sensory neurons were stimulated by a TRPV1 agonist capsaicin (12.5nM, 125nM and 1.25µM) or by a mixture of G-protein coupled receptors agonist (GPCR: bradykinin, histamine and serotonin; 1µM, 10µM and 100µM). We next measured the neuronal production of substance P and calcitonin gene-related peptide (CGRP), two neuropeptides associated with nociception, in response to capsaicin (1.25µM) or GPCR agonists (100µM) by ELISA and EIA, respectively. Results The percentage of neurons responding to capsaicin and GPCR agonists was similar in male and female SPF and GF mice. However, the intensity of the neuronal response was higher in SPF male compared to SPF female in response to capsaicin (125nM: p=0.0336; 1.25µM: p=0.033) but not to GPCR agonists. Neuronal activation was similar in GF and SPF mice of both sexes after administration of capsaicin or GPCR agonists. Furthermore, substance P and CGRP production by sensory neurons induced by capsaicin or GPCR agonists was similar in SPF and GF mice, regardless of sex. However, while the response to capsaicin was similar, the GPCR agonists-induced production of substance P was higher in SPF male mice compared to SPF females (p=0.003). The GPCR agonists-induced production of CGRP was similar in SPF male and female mice. Conclusions Our data suggest that at the level of DRG neurons, the absence of gut microbiota does not predispose to visceral hypersensitivity. The intensity of DRG neuronal responses to capsaicin and the GPCR agonists-induced production of substance P are higher in male compared to female mice, in contrast to previously published studies in various models of acute and chronic pain. Further studies are thus needed to investigate the role of sex in visceral sensitivity. Funding Agencies CIHR

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Yang, S., L. C. Edman, J. A. Sanchez-Alcaniz, N. Fritz, S. Bonilla, J. Hecht, P. Uhlen, et al. "Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons." Journal of Cell Science 126, no. 22 (November 15, 2013): e1-e1. http://dx.doi.org/10.1242/jcs.145136.

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Stockton, Marsha E., and Kurt Rasmussen. "Electrophysiological Effects of Olanzapine, a Novel Atypical Antipsychotic, on A9 and A10 Dopamine Neurons." Neuropsychopharmacology 14, no. 2 (February 1996): 97–104. http://dx.doi.org/10.1016/0893-133x(94)00130-r.

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Yang, S., L. C. Edman, J. A. Sanchez-Alcaniz, N. Fritz, S. Bonilla, J. Hecht, P. Uhlen, et al. "Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons." Development 140, no. 22 (October 23, 2013): 4554–64. http://dx.doi.org/10.1242/dev.098145.

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German, Dwight C., and Kebreten F. Manaye. "Midbrain dopaminergic neurons (nuclei A8, A9, and A10): Three-dimensional reconstruction in the rat." Journal of Comparative Neurology 331, no. 3 (May 15, 1993): 297–309. http://dx.doi.org/10.1002/cne.903310302.

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Bye, Christopher R., Lachlan H. Thompson, and Clare L. Parish. "Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into Parkinsonian mice." Experimental Neurology 236, no. 1 (July 2012): 58–68. http://dx.doi.org/10.1016/j.expneurol.2012.04.002.

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Goldstein, Jeffrey M., Linda C. Litwin, E. B. Sutton, and Jeffrey B. Malick. "D-2 dopamine antagonist-like effects of SCH 23390 on A9 and A10 dopamine neurons." Life Sciences 40, no. 11 (March 1987): 1039–44. http://dx.doi.org/10.1016/0024-3205(87)90565-0.

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Dissertations / Theses on the topic "A9 neurons"

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Olijslagers, Johanna Elisabeth. "Serotonergic modulation of dopamine and GABA inputs to A9 and A10 dopamine neurons and its role in antipsychotic drug efficacy." [S.l : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/19543.

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Saddington, Catherine E. "Obsessions and compulsions in autistic spectrum disorders." Thesis, Canterbury Christ Church University, 2013. http://create.canterbury.ac.uk/12480/.

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Questions have been raised as to whether the patterns of thoughts and behaviours experienced by individuals with autistic spectrum disorders (ASD) can be indicative of comorbid obsessive compulsive disorder (OCD). The current study aimed to compare the experiences of adults with ASD or OCD and healthy controls (HC) in terms of the symptoms experienced and the associated emotions and responses. Associations between autistic traits and OCD severity were explored. A cross-sectional design utilising MANOVA, ANOVA and correlation was employed. Methods: Eighteen participants with ASD, 20 with OCD and 19 healthy controls completed self-report measures and interviews assessing IQ, comorbid diagnoses, OCD symptoms, autistic traits and emotions and responses associated with obsessional thoughts. Participants with ASD scored significantly higher than healthy controls in terms of OCD severity and also number of obsessions and compulsions and associated distress. While the OCD and ASD groups did not differ significantly on OCD severity, the OCD group reported significantly higher levels of sadness, worry, shame, guilt and disapproval triggered by obsessions. The ASD and healthy control groups were largely comparable on these factors. Associations were found between OCD severity and particular domains which are typically impaired in ASD, including social skills, attention switching, communication and imagination. Findings suggest that OCD symptoms may be common and a source of distress in individuals with ASD, thus perhaps warranting psychological intervention. Further research into the exact nature of this distress and how this can be assessed is required.

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Book chapters on the topic "A9 neurons"

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Lacey, M. G., P. Calabresi, and R. A. North. "Cholinergic Excitation of A9 and A10 Dopaminergic Neurones in Vitro through Both Nicotinic and Muscarinic Receptors." In Advances in Behavioral Biology, 275–84. Boston, MA: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5871-8_28.

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