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SINGH, RAJEEV KUMAR. "Lectotypification of three Linnaean names in Impatiens (Balsaminaceae)." Phytotaxa 321, no. 3 (September 19, 2017): 299. http://dx.doi.org/10.11646/phytotaxa.321.3.8.
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The genus Impatiens Linnaeus (1753: 937) consists of about 1000 species, distributed in the tropical and subtropical regions of the Old World as well as in the northern temperate regions (Mabberley 2008). In India there are about 215 species of Impatiens recorded so far, of which 142 species are endemic, and the highest diversity occurs in two regions, viz. the Eastern Himalayas and the Western Ghats (Singh 2016a, 2016b, Singh & Garg 2016). During an ongoing study on the systematics of Impatiens in India, a total of 37 binomials have already been lectotypified and one neotypified previously (Singh 2016a, 2016b). Linnaeus (1753) published 7 names under Impatiens [Impatiens balsamina Linnaeus (1753: 938), I chinensis Linnaeus (1753: 937), I. cornuta Linnaeus (1753: 937), I. latifolia Linnaeus (1753: 937), I. oppositifolia Linnaeus (1753: 937), I. triflora Linnaeus (1753: 938) and I. noli-tangere Linnaeus (1753: 938)] in Species Plantarum. The names I. chinensis, I. cornuta and I. latifolia appear to be yet untypified and are investigated here as a part of systematic study of this genus in India. The designation of the nomenclatural type for these names is based on an assessment of Linnaeus’s original materials and the literature cited in protologue. The images of the selected lectotypes specimens at BM and LINN are available online (http://www.nhm.ac.uk/research-curation/scientific-resources/collections/botanical-collections and http://linnean-online.org/linnaean_herbarium.html).
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Valecce, Anastasia. "Zavattini: Il Neo-Realismo e il Nuovo Cinema Latino-americano Volumi I–II, David Brancaleone (2019)." Journal of Italian Cinema & Media Studies 9, no. 2 (March 1, 2021): 324–29. http://dx.doi.org/10.1386/jicms_00077_5.
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Review of: Zavattini: Il Neo-Realismo e il Nuovo Cinema Latino-americano Volumi I–II, David Brancaleone (2019) Vol. I, Parma: Diabasis, 486 pp., ISBN 978-8-88103-935-7, p/bk, €24.00 Vol. II, Parma: Diabasis 794 pp., ISBN 978-8-88103-937-1, e-book, free
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Esdaille, Ashanda Rosetta Patrice, Jose A. Karam, Philippe E. Spiess, Jay D. Raman, Daniel D. Shapiro, Pranav Sharma, Wade J. Sexton, et al. "Peri-operative morbidity and mortality in a modern series of patients treated with cytoreductive nephrectomy (CN) at five centers." Journal of Clinical Oncology 39, no. 6_suppl (February 20, 2021): 268. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.268.
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268 Background: For metastatic renal cell cancer (mRCC) patients considering cytoreductive nephrectomy (CN), perioperative morbidity is important to discuss but few contemporary multi-institutional data are available. The objective of this study is to describe factors associated with perioperative outcomes in a modern multi-institutional cohort of patients treated with cytoreductive nephrectomy. Methods: Data for perioperative complications was recorded for patients treated with CN at 5 centers from 2005-2019. Postoperative complications within 90 days were categorized using Clavien- Dindo system. Univariate and multivariable analysis was used to evaluate for associations with complications and 90-day mortality. Factors evaluated included receipt of pre-surgical systemic therapy, ECOG performance status (PS), Charlson comorbidity index (CCI), concurrent IVC thrombectomy, age, and surgical approach (open vs. laparoscopic/robotic). Results: Perioperative outcomes were evaluated in 937 consecutive patients treated with CN at 5 institutions from 2005-2019. Median age at surgery was 61 years (IQR 53-68) and median tumor diameter was 9.8cm (IQR 7-12).Venous thrombus was present in 406/937 (43.3%) patients overall including 65/406 (16%) patients for whom IVC thrombus extended above the hepatic veins. Open and laparoscopic/robotic approach was used in 715 (76.3%) and 290 (23.4%) patients. The median ECOG PS was 1 (IQR 0-1) and median CCI was 1 (IQR 0-2). Pre-surgical systemic therapy was given to 243 (25.9%) patients prior to CN. The median length of hospital stay was 5 days (IQR 4-7) and 429 (34.6%) received blood transfusion. Median length of stay was 3.0 (IQR 2-4) for laparoscopic/robotic approach and 6 days (IQR 4-8) for patients with IVC thrombectomy. Hospital readmission within 30 days was identified in 112 (9.0%) patients. A total of 93/937 (9.9%) patients had major (≥Clavien 3) complications identified within 90 days postoperatively. On multivariable analysis, IVC thrombectomy was associated with higher risk of major complications OR 1.95 (95% CI 1.2-3.1), p = 0.006. Pre-surgical systemic therapy, ECOG PS, CCI, age and surgical approach were not associated with major complications (p = 0.09-0.85). Perioperative mortality was 12/937 (1.3%) at 30 days and 51/937 (6.7%) at 90 days. After multivariable analysis, pre-surgical systemic therapy, ECOG PS, CCI, age, and IVC thrombectomy were not associated with perioperative mortality (p = 0.1-0.85). Conclusions: Cytoreductive nephrectomy is associated with major complications for 10% of patients and 1% mortality at 30 days. Pre-surgical systemic therapy was not associated with increased risk of complications or mortality.
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Pina-Jiménez, Emmanuel, Fernando Calzada, Elihú Bautista, Rosa María Ordoñez-Razo, Claudia Velázquez, Elizabeth Barbosa, and Normand García-Hernández. "Incomptine A Induces Apoptosis, ROS Production and a Differential Protein Expression on Non-Hodgkin’s Lymphoma Cells." International Journal of Molecular Sciences 22, no. 19 (September 29, 2021): 10516. http://dx.doi.org/10.3390/ijms221910516.
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Sesquiterpene lactones are of pharmaceutical interest due their cytotoxic and antitumor properties, which are commonly found within plants of several genera from the Asteraceae family such as the Decachaeta genus. From Decachaeta incompta four heliangolide, namely incomptines A-D have been isolated. In this study, cytotoxic properties of incomptine A (IA) were evaluated on four lymphoma cancer cell lines: U-937, Farage, SU-DHL-2, and REC-1. The type of cell death induced by IA and its effects on U-937 cells were analyzed based on its capability to induce apoptosis and produce reactive oxygen species (ROS) through flow cytometry with 4′,6-diamidino-2-phenylindole staining, dual annexin V/DAPI staining, and dichlorofluorescein 2′,7′-diacetate, respectively. A differential protein expression analysis study was carried out by isobaric tags for relative and absolute quantitation (iTRAQ) through UPLC-MS/MS. Results reveal that IA exhibited cytotoxic activity against the cell line U-937 (CC50 of 0.12 ± 0.02 μM) and the incubation of these cells in presence of IA significantly increased apoptotic population and intracellular ROS levels. In the proteomic approach 1548 proteins were differentially expressed, out of which 587 exhibited a fold-change ≥ 1.5 and 961 a fold-change ≤ 0.67. Most of these differentially regulated proteins are involved in apoptosis, oxidative stress, glycolytic metabolism, or cytoskeleton structuration.
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Bengio, S., D. Gilbert, P. Peulve, M. Daveau, and M. Fontaine. "Biosynthesis of the third component of complement (C3) by the human monocytic-cell line U-937 Induction by phorbol myristate acetate." Biochemical Journal 239, no. 3 (November 1, 1986): 711–16. http://dx.doi.org/10.1042/bj2390711.
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Phorbol myristate acetate (PMA)-stimulated human monocyte-like cells (U-937) were found to synthesize the third component of complement (C3), as shown by enzyme-linked immunosorbent assay and immunoprecipitation from [35S]methionine-labelled culture supernatants. C3 synthesis occurred at a rate of about 160 ng of C3/24 h per 10(6) cells on day 7 after addition of PMA; it was blocked by cycloheximide treatment and was restored after removal of the inhibitor. SDS/polyacrylamide-gel-electrophoretic analysis of the immunoprecipitated protein showed that the size and subunit structure of the newly synthesized C3 were identical with those of plasma C3, and that a single-chain intracellular precursor was present in the cell lysates. Haemolytic assays showed that the synthesized C3 fully expressed functional activity in early culture within 4 h. After longer culture, a loss of haemolytic activity was observed. The possibility that newly secreted C3 is cleaved by U-937 cells themselves was suggested.
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Kantengwa, S., A. M. Capponi, J. V. Bonventre, and B. S. Polla. "Calcium and the heat-shock response in the human monocytic line U-937." American Journal of Physiology-Cell Physiology 259, no. 1 (July 1, 1990): C77—C83. http://dx.doi.org/10.1152/ajpcell.1990.259.1.c77.
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In the human monocytic line U-937, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] increases cytosolic free calcium concentration ([Ca2+]i). 1,25-(OH)2D3 also enhances the synthesis of heat-shock proteins (HSPs) when U-937 cells are exposed to elevated temperatures. To establish whether these two effects of 1,25-(OH)2D3 are related, we examined the effects of calcium on the heat-shock (HS) response, as well as the influence of 1,25-(OH)2D3 on this system. The equilibrium dissociation constant (Kd) of the fluorescent probe used to measure [Ca2+]i, fura-2, at 37 and 45 degrees C was found to be 191 and 234 nM, respectively. Exposure of U-937 cells to 45 degrees C did not increase [Ca2+]i under conditions in which active efflux of the dye was prevented by the organic anion transport inhibitor probenecid (1 mM). In cells preincubated in calcium-free medium, with subsequent addition of 4 mM EGTA before HS, or exposed to the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), the increase in HSPs synthesis was not affected. Cell viability, assessed by [3H]thymidine uptake, was not different between cells exposed to HS in calcium-containing or calcium-free media. Moreover, the effects of 1,25-(OH)2D3 on the HS response were also observed in a calcium-depleted medium, indicating that the effects of 1,25-(OH)2D3 on HSP synthesis were not mediated by [Ca2+]i.
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Rammeh, Soumaya, Emna Romdhane, Amira Arfaoui Toumi, Yoldez Houcine, Rym Lahiani, Asma Sassi, Helmi Mardassi, Mamia Ben Salah, and Mohamed Ferjaoui. "Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis." Acta Cytologica 62, no. 2 (2018): 99–103. http://dx.doi.org/10.1159/000487503.
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Objective: This study assesses the role of fine-needle aspiration cytology (FNAC) in the diagnosis of tuberculous lymphadenitis (TL) in comparison with histology and bacteriology findings. Study Design: We undertook a descriptive retrospective study of 937 FNAC specimens from 851 patients with cervical lymph nodes. The FNAC findings were then compared to histopathology and bacteriology. Results: Of the 937 aspirates, the cytopathological diagnoses consisted of 426 (55.9%) TL, 185 (24.3%) reactive lymphoid hyperplasia, 18 (2.3%) suppurative inflammation, 78 (10.2%) malignant metastatic tumor, and 54 (7%) lymphoma. Of the 426 TL cases, 171 were diagnosed by FNAC combined with bacteriological examination. In this group, 22 cases were found to be positive on Ziehl-Neelsen stain and 16 by culture. A histopathology report was available for 62 cases. Compared to histopathology, the overall diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FNAC in the diagnosis of cervical TL were, respectively, 96.77, 100, 100, and 96.67%. When comparing bacteriology to histopathology, these values were 97.44, 100, 100, and 91.67%. Conclusion: Our study shows that FNAC is a sensitive and specific tool for the diagnosis of cervical TL.
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Tesfaye, Solomon, Hannah Braun, Kaleab Asres, Ephrem Engidawork, Anteneh Belete, Ilias Muhammad, Christian Schulze, Nadin Schultze, Sebastian Guenther, and Patrick J. Bednarski. "Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer; Part 3: Selective Cytotoxic Activity of 22 Plants against Human Cancer Cell Lines." Molecules 26, no. 12 (June 15, 2021): 3658. http://dx.doi.org/10.3390/molecules26123658.
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Medicinal plants have been traditionally used to treat cancer in Ethiopia. However, very few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro-ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol extracts of 22 plants against human peripheral blood mononuclear cells (PBMCs), as well as human breast (MCF-7), lung (A427), bladder (RT-4), and cervical (SiSo) cancer cell lines. Active extracts were further screened against human large cell lung carcinoma (LCLC-103H), pancreatic cancer (DAN-G), ovarian cancer (A2780), and squamous cell carcinoma of the esophagus (KYSE-70) by using the crystal violet cell proliferation assay, while the vitality of the acute myeloid leukemia (HL-60) and histiocytic lymphoma (U-937) cell lines was monitored in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) microtiter assay. Euphorbia schimperiana, Acokanthera schimperi, Kniphofia foliosa, and Kalanchoe petitiana exhibited potent antiproliferative activity against A427, RT-4, MCF-7, and SiSo cell lines, with IC50 values ranging from 1.85 ± 0.44 to 17.8 ± 2.31µg/mL. Furthermore, these four extracts also showed potent antiproliferative activities against LCLC-103H, DAN-G, A2780, KYSE-70, HL-60, and U-937 cell lines, with IC50 values ranging from 0.086 to 27.06 ± 10.8 µg/mL. Hence, further studies focusing on bio-assay-guided isolation and structural elucidation of active cytotoxic compounds from these plants are warranted.
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Lykov, A. P., S. N. Belogorodtsev, E. K. Nemkova, A. Vetlugina, T. M. Terekhova, and Ya Sh Schwartz. "Effect of mevalonate, zoledronate and BCG on monocyte/macrophage phenotype." Сибирский научный медицинский журнал 43, no. 3 (June 23, 2023): 57–63. http://dx.doi.org/10.18699/ssmj20230306.
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Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with the pathogen, the so-called trained immunity. Mevalonate pathway metabolites play an important role in the formation of trained immunity. The aim of this investigation was to study the effect of modulators of mevalonate pathway, mevalonate and zoledronate, on the formation of trained immunity in human and animal monocytes/ macrophages.Material and methods. Human monocyte-like cell lines THP-1 and U-937, peritoneal macrophages of BALB/c mice were used. Trained immunity was induced in vitro by incubation of THP-1 and U-937 monocyte-like cell lines for 24 and 72 hours with inactivated Mycobacteria of BCG vaccine strain, and in vivo by intraperitoneal administration of BCG to BALB/c mice with isolation of peritoneal macrophages on day 7 after infection (lag phase). Cell hyperreactivity was assessed by response to a second stimulus with bacterial lipopolysaccharide (LPS) and mevalonate, zoledranate in the presence or absence of LPS. Lactate, cytokine (IL-1β, TNF-α, IL-10), nitric oxide and glucose level was measured in conditioned media from cells.Results and discussion. The study showed that monocyte-like cell lines THP-1 and U-937 responded differently by cytokine production, lactate, and glucose consumption to BCG stimulus in the presence or absence of lag phase. Mevalonate and zoledronate alone or in combination with LPS also stimulated cytokine production in different ways. The presence of lag phase for human monocyte-like cells is essential for the level of cytokine production and glucose consumption. Peritoneal macrophages have been shown to enhance pro-inflammatory cytokine production in response to LPS, mevalonate, and zoledronate.Conclusions. Mevalonate and zoledronate induce trained immunity in monocytes/macrophages.
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Miceli, Marco, Adele Cutignano, Mariarosaria Conte, Raffaella Ummarino, Alessandra Romanelli, Menotti Ruvo, Marilisa Leone, et al. "Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells." Marine Drugs 17, no. 11 (November 1, 2019): 625. http://dx.doi.org/10.3390/md17110625.
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Microalgae are an excellent source of valuable compounds for nutraceutical and cosmeceutical applications. These photosynthesizing microorganisms are amenable for large-scale production, thus overcoming the bottleneck of biomass supply for chemical and activity characterization of bioactive compounds. This characteristic has recently also prompted the screening of microalgae for potential pharmaceutical applications. Here, we show that monoacylglycerides (MAGs) purified from the marine diatom Skeletonema marinoi have selective cytotoxic activity against the haematological cancer cell line U-937 and colon cancer cell line HCT-116 compared to normal MePR-2B cells. LC-MS analysis of the raw extract revealed that in their natural form, MAGs occur as 2-monoacyl derivatives and include mainly C16 and C20 analogues, but they are converted into the corresponding 1-isomers during purification processes. Pure compounds along with the synthetic 1-monoarachidonoylglycerol tested on HCT-116 and U-937 tumor cell lines induced cell death via apoptosis. The mechanism of action was investigated, and we show that it involves the induction of apoptosis through caspase 3/7 activation. These findings pave the way for the possible use of these molecules as potential anticancer agents or as precursors for the generation of new and more potent and selective compounds against tumor cells.
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Saavedra, Ester, Francisco Estévez-Sarmiento, Mercedes Said, José Luis Eiroa, Sara Rubio, José Quintana, and Francisco Estévez. "Cytotoxicity of the Sesquiterpene Lactone Spiciformin and Its Acetyl Derivative against the Human Leukemia Cell Lines U-937 and HL-60." International Journal of Molecular Sciences 21, no. 8 (April 16, 2020): 2782. http://dx.doi.org/10.3390/ijms21082782.
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Spiciformin (1) is a sesquiterpene lactone with a germacrane skeleton that is found in two Tanacetum species endemic to the Canary Islands. In this study, the cytotoxicities of 1 and its acetyl derivative (2) were evaluated against human tumor cells. These sesquiterpene lactones were cytotoxic against human acute myeloid leukemia (U-937 and HL-60) cells, even in cells over-expressing the pro-survival protein Bcl-2, but melanoma (SK-MEL-1) and human mononuclear cells isolated from blood of healthy donors were more resistant. Both compounds are apoptotic inducers in human leukemia U-937 cells. Cell death was mediated by the processing and activation of initiator and effector caspases and the cleavage of poly(ADP-ribose) polymerase, and it was blocked by a broad-spectrum caspase inhibitor and (in the case of sesquiterpene lactone 2) by the selective caspase-3/7, -8, and -9 inhibitors. In addition, certainly in the case of compound 2, this was found to be associated with a decrease in mitochondrial membrane potential, downregulation of the anti-apoptotic protein Bcl-2, activation of the mitogen-activated protein kinases signaling pathway, and generation of reactive oxygen species. It will, therefore, be relevant to continue characterization of this class of compounds.
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K AlMazroua, Maha, Sahar Y Issa, and Essam M Hafez. "Tele-health: bridging the gap between the need for rapid toxicology consultation and shortage in poison control centers - a unique experience in Dammam poison control center." International Journal of Pharmacology and Toxicology 4, no. 1 (April 18, 2016): 59. http://dx.doi.org/10.14419/ijpt.v4i1.5944.
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<p>The development of poisons control centers (PCCs) has in general complied with the actual needs and conditions in the society. A single MOH toll-free telephone number (937) for all health services enables rapid transfer of the caller to a specialist in poison information and toxicology anywhere in the Saudi Kingdom at any time, day or night. A board-certified, qualified toxicologist can be reached within a few moments. This remarkable system is maintained by the voluntary cooperation of the 45 technical members of the Regional Dammam Poison Control Center (DPCC) since nearly three years, being the only PCC in the Kingdom offering this service till date.</p><p><strong>Objectives:</strong> The objective of the current study is to empathize and promote services delivered by PCCs as poison control, chemical safety, prevention and treatment of toxicities within the Saudi Kingdom through the single MOH toll-free telephone number (937), being the only Saudi PCC responding to this service in toxicology. It promotes toxicovigilance in the hope of decreasing the overall morbidity and minimizing mortality from poisoning.</p><p><strong>Methods:</strong> The calls received on the hotline telephone number of the DPCC directly conveying the calls from the free MOH line (937), were retrospectively studied and evaluated. Themes that emerged from the data obtained from telephone communication were statistically assessed.</p><p><strong>Results:</strong> The study showed that the Unintentional exposures (N= 4353, 85%) greatly surpassed other types of exposure. Most of the callers were Saudi (N=4198, 82%) from Eastern region (N= 1654, 32.3%). The toxicological calls (N: 2389, 87.6%) were nearly 7 folds of the non-toxicological calls (N: 337, 12.4%) in the third year of the study. The number of calls were more during the summer season.</p>
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Borges, Adrian C., Alessandro Pingitore, Adriana Cordovil, Eugenio Picano, and Gert Baumann. "937-7 Is Lack of Hyperkinesis a “Normal Variant” During Dobutamine Stress? A Quantitative Two-Dimensional Echocardiographic Study." Journal of the American College of Cardiology 25, no. 2 (February 1995): 160A. http://dx.doi.org/10.1016/0735-1097(95)92119-p.
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Macelloni, G., S. Paloscia, P. Pampaloni, E. Santi, and M. Tedesco. "Microwave radiometric measurements of soil moisture in Italy." Hydrology and Earth System Sciences 7, no. 6 (December 31, 2003): 937–48. http://dx.doi.org/10.5194/hess-7-937-2003.
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Abstract. Within the framework of the MAP and RAPHAEL projects, airborne experimental campaigns were carried out by the IFAC group in 1999 and 2000, using a multifrequency microwave radiometer at L, C and X bands (1.4, 6.8 and 10 GHz). The aim of the experiments was to collect soil moisture and vegetation biomass information on agricultural areas to give reliable inputs to the hydrological models. It is well known that microwave emission from soil, mainly at L-band (1.4 GHz), is very well correlated to its moisture content. Two experimental areas in Italy were selected for this project: one was the Toce Valley, Domodossola, in 1999, and the other, the agricultural area of Cerbaia, close to Florence, where flights were performed in 2000. Measurements were carried out on bare soils, corn and wheat fields in different growth stages and on meadows. Ground data of soil moisture (SMC) were collected by other research teams involved in the experiments. From the analysis of the data sets, it has been confirmed that L-band is well related to the SMC of a rather deep soil layer, whereas C-band is sensitive to the surface SMC and is more affected by the presence of surface roughness and vegetation, especially at high incidence angles. An algorithm for the retrieval of soil moisture, based on the sensitivity to moisture of the brightness temperature at C-band, has been tested using the collected data set. The results of the algorithm, which is able to correct for the effect of vegetation by means of the polarisation index at X-band, have been compared with soil moisture data measured on the ground. Finally, the sensitivity of emission at different frequencies to the soil moisture profile was investigated. Experimental data sets were interpreted by using the Integral Equation Model (IEM) and the outputs of the model were used to train an artificial neural network to reproduce the soil moisture content at different depths. Keywords: microwave radiometry, soil moisture mapping, river basins, vegetative biomass, neural networks
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Comeau, Darin, Douglas A. Kurtze, and Juan M. Restrepo. "A conceptual model of oceanic heat transport in the Snowball Earth scenario." Earth System Dynamics 7, no. 4 (December 2, 2016): 937–51. http://dx.doi.org/10.5194/esd-7-937-2016.
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Abstract. Geologic evidence suggests that the Earth may have been completely covered in ice in the distant past, a state known as Snowball Earth. This is still the subject of controversy, and has been the focus of modeling work from low-dimensional models up to state-of-the-art general circulation models. In our present global climate, the ocean plays a large role in redistributing heat from the equatorial regions to high latitudes, and as an important part of the global heat budget, its role in the initiation a Snowball Earth, and the subsequent climate, is of great interest. To better understand the role of oceanic heat transport in the initiation of Snowball Earth, and the resulting global ice covered climate state, the goal of this inquiry is twofold: we wish to propose the least complex model that can capture the Snowball Earth scenario as well as the present-day climate with partial ice cover, and we want to determine the relative importance of oceanic heat transport. To do this, we develop a simple model, incorporating thermohaline dynamics from traditional box ocean models, a radiative balance from energy balance models, and the more contemporary "sea glacier" model to account for viscous flow effects of extremely thick sea ice. The resulting model, consisting of dynamic ocean and ice components, is able to reproduce both Snowball Earth and present-day conditions through reasonable changes in forcing parameters. We find that including or neglecting oceanic heat transport may lead to vastly different global climate states, and also that the parameterization of under-ice heat transfer in the ice–ocean coupling plays a key role in the resulting global climate state, demonstrating the regulatory effect of dynamic ocean heat transport.
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Dixon, P. G., D. M. Brommer, B. C. Hedquist, A. J. Kalkstein, G. B. Goodrich, J. C. Walter, C. C. Dickerson, S. J. Penny, and R. S. Cerveny. "Heat Mortality Versus Cold Mortality: A Study of Conflicting Databases in the United States." Bulletin of the American Meteorological Society 86, no. 7 (July 2005): 937–44. http://dx.doi.org/10.1175/bams-86-7-937.
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Bernatsky, Sasha, Alaa Dekis, Marie Hudson, Christian A. Pineau, Gilles Boire, Paul R. Fortin, Louis Bessette, et al. "Rheumatoid arthritis prevalence in Quebec." BMC Research Notes 7, no. 1 (2014): 937. http://dx.doi.org/10.1186/1756-0500-7-937.
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Patel, Bhavika, Stephanie Allen, Tania Eliseeva, Najiba Mammadova, Agnes Haggerty, and Navi Mehra. "937 Advanced understanding of the tumor microenvironment with multiplex analysis: an automated 7-color multiplex assay using Akoya’s opal technology." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A983. http://dx.doi.org/10.1136/jitc-2021-sitc2021.937.
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BackgroundImmunotherapy and precision medicine are rapidly developing approaches to cancer therapy. Biomarkers that detect the tumor and tumor microenvironment allow for the development of strategies that accelerate the development of treatments that enhance a patient‘s immune system. Akoya’s MOTiF™ PD-1/PD-L1 Panel is a validated, multiplex immunoassay enabling detection of the 6 most clinically relevant immuno-oncology and spatial markers: PD-1, PD-L1, FoxP3, CD8, CD68, and PanCK. This panel provides unparalleled quantitative data for pre-clinical and translational IO research.MethodsThe MOTiF™ PD-1/PD-L1 Panel was used to stain normal and tumor lung tissues. Stained slides were analyzed using the InForm® and Visiopharm® image analysis platforms.ResultsWe introduce the workflow and image analysis solutions using InForm® and Visiopharm® software to provide robust, quantifiable data.ConclusionsThis data provides insight into the innate and adaptive immune environment for targeted design of new immunotherapies. These new targeted immunotherapies could potentially improve efficacy and reduce toxicity.
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Goyal, Ankush, Baljeet Kaur, Amandeep Kaur, Vivek K. Gupta, and Monika Gupta. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-A] PYRIMIDINE-3,5-DIONES." INDIAN DRUGS 60, no. 07 (July 28, 2023): 16–22. http://dx.doi.org/10.53879/id.60.07.12341.
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The organosulphur thiazolo-pyrimidines are fused heterocyclic compounds that can be anticipated as 7-thio counterparts of the genuine purine bases such as guanine and adenine. They have attained a growing significance in the domain of drug chemistry because of their diverse pharmacological activities. In the current study, 2-substituted benzylidene-7-methyl-2H-thiazolo [3,2-a] pyrimidine-3,5-dione derivatives were synthesised. The synthetic compounds were tested against the human myelomonocytic leukaemia cell line (U-937) for their ability to inhibit cancer cell growth as well as against Gram negative E. coli (MTCC 40) and Gram positive S. aureus (MTCC 87) for their ability to inhibit bacterial growth. The amine and halogen containing compounds exhibited the strongest anticancer and antibacterial effects among all the derivatives in series (7a-j). Compounds 7h, 7e, 7a, 7b, 7c, 7i, and 7j displayed improved activity in both assays compared to standard andriyamycin and ciprofloxacin, whereas 7d, 7f, and 7g were shown to be moderately active. Through the use of IR, NMR and mass spectrum analyses, the molecular structures of the synthesized compounds were determined.
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GONZALES, M. L. A., V. BIANCO, and A. VYSE. "Meningococcal carriage in children and young adults in the Philippines: a single group, cross-sectional study." Epidemiology and Infection 145, no. 1 (September 22, 2016): 126–32. http://dx.doi.org/10.1017/s0950268816002119.
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SUMMARYThis cross-sectional prevalence study investigates meningococcal carriage for the first time in a Southeast Asian population. Posterior pharyngeal swabs were collected between August 2013 and March 2014 from 937 healthy Filipinos aged 5–24 years attending school or university in Manila. Of these, 35 were found to be carriers giving an overall carriage prevalence of 3·7% [95% confidence interval (CI) 2·6–5·2]. Carriage was associated with age (P < 0·001) and was highest (9·0%, 95% CI 5·5–13·8) in subjects aged 10–14 years, but was comparatively low (<3%) in all other age groups considered. This suggests that an immunization programme in the Philippines designed to reduce carriage acquisition and induce herd immunity may require a vaccine dose before the age of 10 years. Serogroup B was most commonly carried (65·7%, 95% CI 47·8–80·9), with a small number of carriers for serogroups C, Y and W also present. Two individuals (5·7%, 95% CI 0·7–19·2) who were simultaneously carrying multiple serogroups were identified. This exploratory study provides valuable insight into the asymptomatic carriage of Neisseria meningitidis in a healthy subset of the Filipino population and illustrates the importance of generating local carriage data.
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El-Kalyoubi, Samar, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, and Mona S. El-Zoghbi. "Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies." Pharmaceuticals 16, no. 9 (September 15, 2023): 1303. http://dx.doi.org/10.3390/ph16091303.
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Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as dual BRD4 and PLK1 inhibitors. MTT assays of synthesized compounds against breast (MDA-MB-231), colorectal (HT-29), and renal (U-937) cancer cells showed excellent-to-good cytotoxic activity, compared to Methotrexate; MDA-MB-231 were the most sensitive cancer cells. The most active compounds were tested against normal Vero cells. Compounds 4 and 7 significantly inhibited BRD4 and PLK1, with IC50 values of 0.029, 0.042 µM, and 0.094, 0.02 µM, respectively, which are nearly comparable to volasertib (IC50 = 0.017 and 0.025 µM). Compound 7 triggered apoptosis and halted cell growth at the G2/M phase, similarly to volasertib. It also upregulated the BAX and caspase-3 markers while downregulating the Bcl-2 gene. Finally, active compounds fitted the volasertib binding site at BRD4 and PLK1 and showed ideal drug-like properties and pharmacokinetics, making them promising anticancer candidates.
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Esbenshade, Adam J., Zhiguo Zhao, Alaina Baird, Emily A. Holmes, Daniel E. Dulek, Ritu Banerjee, and Debra L. Friedman. "Prospective Implementation of a Risk Prediction Model for Bloodstream Infection Safely Reduces Antibiotic Usage in Febrile Pediatric Cancer Patients Without Severe Neutropenia." Journal of Clinical Oncology 38, no. 27 (September 20, 2020): 3150–60. http://dx.doi.org/10.1200/jco.20.00591.
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PURPOSE Management of febrile pediatric patients with cancer with an absolute neutrophil count of 500/µL or greater is unclear. The Esbenshade Vanderbilt (EsVan) risk prediction models have been shown to predict bloodstream infection (BSI) likelihood in this population, and this study sought to prospectively validate and implement these models in clinical practice. METHODS Data were prospectively collected on febrile pediatric patients with cancer with a central venous catheter from April 2015 to August 2019 at a single site, at which the models (EsVan: 2015 to 2017; EsVan2: October 2017 to 2019) were initially developed and subsequently implemented for clinical management in well-appearing nonseverely neutropenic individuals. It was recommended that patients with low BSI risk (< 10%) be discharged home without antibiotics, those with intermediate BSI risk (10%-39.9%) be administered an antibiotic before discharge, and those with high BSI risk (> 40%) be admitted on broad-spectrum antibiotics. Seven-day outcomes were then collected and EsVan models were prospectively validated and C-statistics estimated. RESULTS In 937 febrile, nonsevere neutropenia episodes, frequencies of low-, intermediate-, and high-risk episodes were 88.9%, 8.6%, and 2.3% respectively. BSI incidence was 4.2% (39 of 937). Within risk groups, low-risk BSI incidence was 1.9% (16 of 834) with BSI incidence of 13.6% and 54.5% for intermediate- and high-risk episodes, respectively. Empirical intravenous antibiotics were administered in 21.1% of low-risk episodes at presentation and at 7 days postpresentation, 72.3% of episodes never required intravenous antibiotics. There were no deaths or clinical decompensations attributable to antibiotic delay. For BSI detection, EsVan and EsVan2 models applied to the new cohort achieved C-statistics of 0.802 and 0.824, respectively. CONCLUSION Prospective, real-time clinical utilization of the EsVan models accurately predicts BSI risk and safely reduces unnecessary antibiotic use in febrile, nonseverely neutropenic pediatric patients with cancer.
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Khan, TN. "Effects of fungicide treatments on scald (Rhynchosporium secalis (Oud.) J. Davis) infection and yield of barley in Western Australia." Australian Journal of Experimental Agriculture 26, no. 2 (1986): 231. http://dx.doi.org/10.1071/ea9860231.
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Application of fungicides (benomyl and triadimefon) to early sown barley (cv. Clipper) in 1979 and 1980 reduced the incidence of scald and greatly increased grain yield. Fungicide applied to the young crop 4-6 weeks after sowing was ineffective but applications at 10 and 12 weeks indicated that economic returns from the use of fungicides could be obtained. In subsequent experiments on cv. Stirling, an application at the 6-7 leaf stage gave the most consistent grain yield increase, ranging from 15 to 48% (225-937 kg/ha). Triadimefon was found to be more effective in reducing scald than was benomyl but gave no greater yield increases. Controlling scald by multiple application of fungicide increased harvest dry weight, number of heads/m2, number of grains/head and 100-seed weight, and prevented lodging in at least two trials. A single application, though it may be economic, offers only partial control of scald, and resistant cultivars are therefore necessary to achieve full yield potential in scald-prone areas.
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Mashuri, Yusuf Ari, David Boettiger, Siska Dian Wahyuningtias, Srila Nirmithya Salita Negara, Yanri Wijayanti Subronto, Marco Liverani, Luh Putu Lila Wulandari, et al. "“I pity the TB patient”: a mixed methods study assessing the impact of the COVID-19 pandemic on TB services in two major Indonesian cities and distilling lessons for the future." BMJ Global Health 9, no. 5 (May 2024): e014943. http://dx.doi.org/10.1136/bmjgh-2023-014943.
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IntroductionIn Indonesia, a country with around 280 million people and the second-highest tuberculosis (TB) incidence rate in the world, the impact of the COVID-19 pandemic on TB care needs careful assessment so that future response strategies can be strengthened. We conducted a study comparing TB testing and treatment rates before and during the first 2 years of the COVID-19 pandemic in Indonesia, and the reasons for any disruptions to care.MethodsWe conducted retrospective secondary data analysis and qualitative interviews in Yogyakarta and Bandung, Indonesia. Routine data on TB testing and treatment were sourced from the national TB information system operated by the Indonesian Ministry of Health. TB testing and treatment outcomes were compared between two time periods: pre-COVID (2018–19); and during COVID-19 (2020–21). In-depth interviews were conducted with patients and health workers to explore their experiences in accessing and providing TB services during the pandemic.ResultsThere was a 45% (21 937/39 962) reduction in the number of patients tested for TB during the pandemic compared with pre-COVID-19, while the proportion of TB tests returning a positive result increased from 12% (4733/39 962) to 50% (10 945/21 937). The proportion of TB patients completing treatment increased by 2.6% during the pandemic, yet the proportion cured and the number of patients successfully treated both decreased (by 7% and 4.4%, respectively). Our qualitative interviews highlighted several factors influencing TB service access and delivery, including fear of being diagnosed with COVID-19 during TB-related clinic visits, fear of COVID-19 exposure among patients and health workers, healthcare facilities prioritising COVID-19 over other services, and mandatory mobility restrictions affecting both patients and health workers.ConclusionThe COVID-19 pandemic impacted TB testing and treatment outcomes in Bandung and Yogyakarta. Policymakers should consider these findings in designing strategies to ensure TB services are maintained and supported during future health crises.
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Fan, Yun, Emanuel M. Schreiber, Angela Giorgianni, Jack C. Yalowich, and Billy W. Day. "Myeloperoxidase-Catalyzed Metabolism of Etoposide to Its Quinone and Glutathione Adduct Forms in HL60 Cells Volume 19, Number 7, July 2006, pp 937−943." Chemical Research in Toxicology 20, no. 7 (July 2007): 1067. http://dx.doi.org/10.1021/tx7001806.
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Brown, Meghan, Nir Melamed, Beth Murray-Davis, Haroon Hassan, Karizma Mawjee, Jon Barrett, Sarah D. McDonald, Joel G. Ray, Michael Geary, and Howard Berger. "Timing of delivery in women with pre-pregnancy diabetes mellitus: a population-based study." BMJ Open Diabetes Research & Care 7, no. 1 (December 2019): e000758. http://dx.doi.org/10.1136/bmjdrc-2019-000758.
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ObjectivesControversy exists about the timing of delivery of women with pre-pregnancy type 1 and 2 diabetes mellitus (PDM). This study aims to compare maternal and neonatal outcomes after induction of labor (IOL) at 38 weeks’ gestation versus expectant management from 39 weeks onward.Research design and methodsThis was a retrospective population-based cohort study using data from the Better Outcomes Registry and Network in Ontario Canada. Included were all women with PDM, who had a singleton hospital birth at ≥380/7 weeks’ gestation from 2012 to 2017. Maternal and perinatal outcomes were compared between 937 pregnancies that underwent IOL at 380/7–386/7 weeks (‘38-IOL group’) versus 1276 pregnancies expectantly managed resulting in a birth at ≥390/7 weeks (‘39-Exp group’). The primary outcome was all-cause cesarean delivery. Multivariable modified Poisson regression was performed to generate adjusted relative risks (aRR) and 95% CIs, adjusted for parity, maternal age, pre-pregnancy body mass index and PDM type. Other outcomes included instrumental delivery, neonatal intensive care unit (NICU) admission, and newborn metabolic disturbances.ResultsCesarean delivery occurred in 269 women (28.7%) in the 38-IOL group versus 333 women (26.1%) in the 39-Exp group—aRR 1.07 (95% CI 0.94 to 1.22). The respective rates of instrumental delivery were 11.2% and 10.2% (aRR 1.25, 95% CI 0.98 to 1.61). NICU admission was more common in the 38-IOL group (27.6%) than in the 39-Exp group (16.8%) (aRR 1.61, 95% CI 1.36 to 1.90), as were jaundice requiring phototherapy (12.4% vs 6.2%) (aRR 1.93, 95% CI 1.46 to 2.57) and newborn hypoglycemia (27.3% vs 14.7%) (aRR 1.74, 95% CI 1.46 to 2.07).ConclusionIn pregnant women with PDM, IOL at 380/7–386/7 weeks was not associated with a higher risk of cesarean delivery, compared with expectant management, but was associated with a higher risk of certain adverse neonatal outcomes.
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Mouly, Enguerran, Cecile Planquette, Emilie Rousseau, and Remi Delansorne. "Inecalcitol Enhances Daratumumab-Induced Antibody-Dependent Cell Cytotoxicity Towards Multiple Myeloma and Acute Myeloid Leukemia Cell Lines." Blood 132, Supplement 1 (November 29, 2018): 1447. http://dx.doi.org/10.1182/blood-2018-99-110527.
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Abstract Daratumumab (DARA), the first monoclonal antibody directed against CD38, received accelerated approval in 2015 and regular approval in 2016 by the Food and Drug Administration for the treatment of relapsed/refractory multiple myeloma (MM) (Bhatnagar et al., 2017); its therapeutic indications were recently extended to first-line newly diagnosed MM patients in combination with standards of care following a positive clinical trial in this setting (Mateos et al., 2018). Therefore, DARA has brought extensive evidence that targeting CD38 is a highly successful strategy against MM (Frerichs et al., 2018; Plesner & Krejcik, 2018; Touzeau & Moreau, 2017). Interestingly, the pretreatment levels of CD38 expression on MM cells were significantly higher in patients who achieved at least partial response (PR) as compared to patients who achieved less than PR (Nijhof et al., 2016); furthermore, low level of CD38 expression has recently been identified as an adverse prognostic factor with high significance (p < 0.001) among MM patients (Arana et al., 2018). Besides MM, there are growing preclinical hints that DARA can be efficacious against acute myeloid leukemia (AML) cell lines (Fatehchand et al., 2016; Buteyn et al., 2018) or even T-cell acute lymphoblastic leukemia cells obtained from children patients (Bride et al., 2018), provided that enough CD38 molecules are present at the surface of the leukemic cells. Inecalcitol (INE: 14epi-,19nor-,23yne-,1,25dihydroxy-cholecalciferol), a vitamin D receptor agonist characterized by potent anti-proliferative and pro-differentiating properties and by a low calcemic potential (Okamoto et al., 2012; Ma et al., 2013; Medioni et al. 2014), has been shown to stimulate CD38 expression levels in 37 out of 38 MM cell lines (ASH 2017) and in 10 out of 11 AML cell lines (ASH 2016, AACR 2018). The next question was to know if this increase in CD38 expression induced by INE resulted in an increase in DARA-induced antibody-dependent cell cytotoxicity (ADCC). We have tested two MM (MM1.S, L-363) and seven AML (HL-60, U-937, THP-1, Molm-13, UOC-M1, OCI-AML2, Kasumi-1) cell lines representative of various levels of spontaneous CD38 cell surface density, as measured in thousands of CD38 molecules per cell by fluorescent anti-CD38 labeling (HIT2 clone) followed by quantitative flow cytometry using Cellquant calibrator beads (BioCytex). They ranged from very high CD38-positive (MM.1S, 51.0 ± 1.6 and UOC-M1, 46.5 ± 4.9) to high (OCI-AML2, 16.6 ± 1.5), low (L-363, 7.1 ± 0.1 and THP-1, 7.0 ± 0.2), very low (Molm-13, 2.1 ± 1.0 and Kasumi-1, 1.1 ± 1.2) and CD38-negative (HL-60, U-937). After exposure to 10 nM INE or vehicle for 72h, DARA-induced ADCC was assessed using either the calcein staining of target cells exposed to healthy donors peripheral blood mononuclear cells (PBMC) as effector cells, or the ADCC Reporter Bioassays Kit from Promega (G7018). After control vehicle incubation, DARA-induced ADCC was concentration-related in the range of 0.01 to 1 µg/mL in all cell lines and achieved a maximum ranging from 7% in THP-1, although a CD38-negative cell line, to respectively 27% and 28% in MM1.S and UOC-M1, the two highest CD38-positive cell lines. However, the correlation between maximal DARA-induced ADCC and CD38 surface density did not reach statistical significance (Spearman's rank correlation r = 0.6134, p = 0.09, n = 9). After incubation with 10 nM INE, the initially CD38-negative U-937 and HL-60 cells were found to express low (7.9 ± 0.3) and high (25.6 ± 7.3) surface CD38 levels, respectively. All the CD38-positive cell lines have shown a marked increase in the number of surface CD38 molecules: MM1.S (228 ± 12), OCI-AML2 (76,7 ± 6.5), UOC-M1 (68.8 ± 3.1), L-363 (63.9 ± 1.6), Molm-13 (38.2 ± 8.9), THP-1 (17.9 ± 0.9) and Kasumi-1 (15.7 ± 3.3) (paired Student's t-test, p = 0.02, n = 7). DARA-induced ADCC was concentration-related in the same 0.01 to 1 µg/mL range. Maximal DARA-induced ADCC was increased by 10 nM INE in all cell lines (paired Student t-test, p = 0.0025, n = 9), ranged from 20% in the lowest CD38-expressing cell line U-937 to 42% in the highest CD38-expressing cell line MM1.S, and was significantly correlated with the number of CD38 molecules/cell (Spearman's rank correlation r = 0.8333, p < 0.01, n = 9). Altogether, these results suggest that inecalcitol could represent a therapeutic agent of choice to enhance the clinical response of MM and AML patients to anti-CD38 antibodies such as daratumumab. Disclosures Mouly: Hybrigenics: Employment. Planquette:Hybrigenics: Employment, Equity Ownership, Patents & Royalties: inventor, but no royalties. Rousseau:Hybrigenics: Employment. Delansorne:Hybrigenics: Employment, Equity Ownership, Membership on an entity's Board of Directors or advisory committees, Patents & Royalties: inventor, but no royalties.
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Li, Tingting, Huanqing Liu, Chunsheng Dong, and Jun Lyu. "Application of miRNA Biomarkers in Predicting Overall Survival Outcomes for Lung Adenocarcinoma." BioMed Research International 2022 (September 12, 2022): 1–15. http://dx.doi.org/10.1155/2022/5249576.
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Background. With the development of research, the importance of microRNAs (miRNAs) in the occurrence, metastasis, and prognosis of lung adenocarcinoma (LUAD) has attracted extensive attention. This study is aimed at predicting overall survival (OS) results through bioinformatics to identify novel miRNA biomarkers and hub genes. Materials and Methods. The data of LUAD-related miRNA and mRNA samples was downloaded from The Cancer Genome Atlas (TCGA) database. Upon screening and pretreatment of initial data, TCGA data were analyzed using R platform and a series of analytical tools to identify biomarkers with high specificity and sensitivity. Results. 7 miRNAs and 13 hub genes that had strong relation to the overall surviving status were identified in patients with LUAD. The expression of seven miRNAs (hsa-miR-19a-3p, hsa-miR-126-5p, hsa-miR-556-3p, hsa-miR-671-5p, hsa-miR-937-3p, hsa-miR-4664-3p, and hsa-miR-4746-5p) could apparently improve the OS rate of patient with LUAD. The 13 hub genes, namely, CCT6A, CDK5R1, CEP55, DNAJB4, EGLN3, HDGF, HOXC8, LIMD1, MKI67, PCP4L1, PPIL1, SCAI, and STK32A, showed a correlation with the OS status. Conclusion. 7 miRNAs were identified as novel biomarkers for the prognosis of patients with LUAD. This study offered a deeper comprehension of LUAD treatment and prognosis from the molecular level and helped enhance the understanding of the pathogenesis and potential molecular events of LUAD.
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Giang, Trần Thị Thu, Hoàng Kim Toản, Nguyễn Đình Thi, and Trần Thị Ánh Tuyết. "NGHIÊN CỨU KHẢ NĂNG SINH TRƯỞNG PHÁT TRIỂN, NĂNG SUẤT VÀ CHẤT LƯỢNG CỦA MỘT SỐ GIỐNG DƯA CHUỘT TẠI TỈNH THỪA THIÊN HUẾ." Tạp chí Khoa học và công nghệ nông nghiệp Trường Đại học Nông Lâm Huế 5, no. 3 (November 24, 2021): 2555–64. http://dx.doi.org/10.46826/huaf-jasat.v5n3y2021.467.
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Nghiên cứu được tiến hành trên 7 giống dưa chuột gồm Champ 937, F1 Phú Nông 779, Kiếm Đài Loan, Madam 579, CUS 067, CUS 070 và giống đối chứng Chaiyo 578. Thí nghiệm thực hiện ngoài đồng ruộng trong vụ Xuân Hè năm 2020 tại tỉnh Thừa Thiên Huế nhằm mục đích đánh giá đặc điểm sinh trưởng, phát triển, năng suất, chất lượng của các giống dưa chuột và xác định được giống dưa chuột phù hợp với điều kiện sinh thái. Kết quả nghiên cứu cho thấy các giống thí nghiệm có thời gian sinh trưởng ngắn ngày (65 - 80 ngày), phù hợp với điều kiện địa phương. Các giống dưa chuột có năng suất thực thu cao hơn so với giống đối chứng (19,87 tấn/ha) như Kiếm Đài Loan (29,93 tấn/ha), CUS 067 (22,26 tấn/ha), F1 Phú Nông 779 (22,60 tấn/ha) và có chất lượng tốt như ruột quả đặc, quả giòn, không bị đắng ở đầu quả, vỏ quả màu xanh đến xanh đậm phù hợp với thị hiếu người tiêu dùng.
ABSTRACT
The study was conducted on seven cucumber varieties including Champ 937, F1 Phu Nong 779, Kiem Taiwan, Madam 579, CUS 067, CUS 070 and Chaiyo 578 as a control. The field experiment was carried out in Spring-Summer crop season of the year 2020 in Thua Thien Hue province to evaluate the growth, development, yield, and quality of these cucumber varieties and to identify the cucumber varieties which are suitable for ecological conditions in Thua Thien Hue province. The results showed that these varieties were a short growing time (from 65 days to 80 days), suitable for local conditions. Kiem Taiwan, CUS 067 and F1 Phu Nong 779 varieties had higher fruit yield, 29.93, 22.26 and 22.60 ton/ha, respectively and better qualities than the control sụch as the inside of cucumber was thick and crunchy, the top of the cucumbers was not bitter, the peels were from green to dark green which were suitable for the tastes of consumers.
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Wu, Pei-Shan, Chih-Yang Wang, Hao-Jen Hsu, Jui-Hung Yen, and Ming-Jiuan Wu. "8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment." Biomolecules 13, no. 11 (October 26, 2023): 1575. http://dx.doi.org/10.3390/biom13111575.
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Background: 8-hydroxydaidzein (8-OHD) is a compound derived from daidzein, known for its anti-inflammatory and anti-proliferative properties in K562 human chronic myeloid leukemia (CML) cells. However, its effects on acute myeloid leukemia (AML) cells have not been fully understood. Method: To investigate its potential anti-AML mechanism, we employed an integrated in vitro–in silico approach. Results: Our findings demonstrate that 8-OHD suppresses the expression of CDK6 and CCND2 proteins and induces cell apoptosis in U-937 cells by activating Caspase-7 and cleaving PARP-1. Microarray analysis revealed that 8-OHD downregulates differentially expressed genes (DEGs) associated with rRNA processing and ribosome biogenesis pathways. Moreover, AML-target genes, including CCND2, MYC, NPM1, FLT3, and TERT, were downregulated by 8-OHD. Additionally, molecular docking software predicted that 8-OHD has the potential to interact with CDK6, FLT3, and TERT proteins, thereby reducing their activity and inhibiting cell proliferation. Notably, we discovered a synergic pharmacological interaction between 8-OHD and cytarabine (Ara-C). Conclusions: Overall, this study provides insights into the therapeutic applications of 8-OHD in treating AML and elucidates its underlying mechanisms of action.
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Fordham, Ric, Ketan Dhatariya, Rachel Stancliffe, Adam Lloyd, Mou Chatterjee, Mevin Mathew, Loveleen Taneja, Mike Gains, and Ulrik Haagen Panton. "Effective diabetes complication management is a step toward a carbon-efficient planet: an economic modeling study." BMJ Open Diabetes Research & Care 8, no. 1 (April 2020): e001017. http://dx.doi.org/10.1136/bmjdrc-2019-001017.
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BackgroundThe management of diabetes-related complications accounts for a large share of total carbon dioxide equivalent (CO2e) emissions. We assessed whether improving diabetes control in people with type 2 diabetes reduces CO2e emissions, compared with those with unchanging glycemic control.MethodsUsing the IQVIA Core Diabetes Model, we estimated the impact of maintaining glycated hemoglobin (HbA1c) at 7% (53 mmol/mol) or reducing it by 1% (11 mmol/mol) on total CO2e/patient and CO2e/life-year (LY). Two different cohorts were investigated: those on first-line medical therapy (cohort 1) and those on third-line therapy (cohort 2). CO2e was estimated using cost inputs converted to carbon inputs using the UK National Health Service’s carbon intensity factor. The model was run over a 50-year time horizon, discounting total costs and quality adjusted life years (QALYs) up to 5% and CO2e at 0%.ResultsMaintaining HbA1c at 7% (53 mmol/mol) reduced total CO2e/patient by 18% (1546 kgCO2e/patient) vs 13% (937 kgCO2e/patient) in cohorts 1 and 2, respectively, and led to a reduction in CO2e/LY gain of 15%–20%. Reducing HbA1c by 1% (11 mmol/mol) caused a 12% (cohort 1) and 9% (cohort 2) reduction in CO2e/patient with a CO2e/LY gain reduction of 11%–14%.ConclusionsWhen comparing people with untreated diabetes, maintaining glycemic control at 7% (53 mmol/mol) on a single agent or improving HbA1c by 1% (11 mmol/mol) by the addition of more glucose-lowering treatment was associated with a reduction in carbon emissions.
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Yamaki, Shohei, and Migifumi Ino. "Alteration of Cellular Compartmentation and Membrane Permeability to Sugars in Immature and Mature Apple Fruit." Journal of the American Society for Horticultural Science 117, no. 6 (November 1992): 951–54. http://dx.doi.org/10.21273/jashs.117.6.951.
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A study was conducted to determine the distribution of sugars in vacuoles, cytoplasm, and free space in apples (Malus domestica Bork) picked at the immature and mature stage of maturity. The volumes of free space and air space were 13.4% and 14.5%, respectively, in immature fruit, and 14.6% and 25.6%, respectively, in mature fruit. The inner cellular volume (vacuole + cytoplasm) was 72% and 60% for immature and mature fruit, respectively. About 90% of each sugar (glucose, fructose, sucrose, and sorbitol) was found in the vacuole. The concentration of total sugar in the inner cell or free space was 326 or 128 mm each in immature fruit and 937 or 406 mm each in mature fruit. Permeability to sugars across the plasma membrane and tonoplast also increased with fruit maturation, 7- to 30-fold for the tonoplast and 4- to 5-fold for the plasma membrane in mature compared to immature fruit. Cells in immature fruit apparently enlarge through higher turgor pressure from sequestering of sugars into vacuoles, and cease to enlarge in mature fruit as the amount of sugar unloading into the fruit is reduced due to the accumulation of sugar in the free space or cytoplasm.
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Rafiee, Parvaneh, Hitoshi Ogawa, Jan Heidemann, Mona S. Li, Mohammed Aslam, Thomas H. Lamirand, Pamela J. Fisher, et al. "Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 6 (December 2003): G1277—G1292. http://dx.doi.org/10.1152/ajpgi.00484.2002.
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Gastroesophageal reflux disease is the most common malady of the esophagus, affecting 7% of the United States population. Histological assessment demonstrates classic inflammatory mechanisms including selective leukocyte recruitment and hemorrhage, suggesting a prominent role for the microvasculature. We isolated and characterized human esophageal microvascular endothelial cells (EC) (HEMEC), examined inflammatory activation in response to cytokines, LPS, and acidic pH exposure, and identified signaling pathways that underlie activation. HEMEC displayed characteristic morphological and phenotypic features including acetylated LDL uptake. TNF-α/LPS activation of HEMEC resulted in upregulation of the cell adhesion molecules (CAM) ICAM-1, VCAM-1, E-selectin, and mucosal addressin CAM-1 (MAdCAM-1), increased IL-8 production, and enhanced leukocyte binding. Both acid and TNF-α/LPS activation lead to activation of SAPK/JNK in HEMEC that was linked to VCAM-1 expression and U-937 leukocyte adhesion. Expression of constitutive inducible nitric oxide synthase in HEMEC was in marked contrast to intestinal microvascular endothelial cells. In this study, we demonstrate that HEMECs are phenotypically and functionally distinct from lower gut-derived endothelial cells and will facilitate understanding of inflammatory mechanisms in esophageal inflammation.
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Antonenko, Ekaterina, and Antonina Lebedeva-Emelina. "Cherubic hymn by Vincenzo Manfredini." St. Tikhons' University Review. Series V. Christian Art 48 (December 30, 2022): 141–59. http://dx.doi.org/10.15382/sturv202248.141-159.
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The paper considers Vincenzo Manfredini's «Cherubic Hymn» discovered by E. Yu. Antonenko in 2018. Until recently, it was only known that Manfredini composed music for the Orthodox Church, but not a single composition was found. Based on analysis of manuscript sources, the work is dated to the period of 1762–1765, which allows us to claim that Manfredini was one of the first authors who composed Orthodox Church music in the new classical style that replaced the older partes style after 1762. "Cherubimskaya" is contained in singing books written in round notation, stored in the fund collection "Cult Music" of the Russian National Museum of Music (Moscow): RNMM. F. 283. N 937, sheet 87 (treble), N 256, sheet 7 (viola), N 878, sheet 30v. (tenor), N 996, sheet 65v. (tenor), N 879, sheet. 19 vol. (bass), N 944, l. 17 (bass). With a high probability, these chanting vowels are of Petersburg origin, and, thus, the indication of Manfredini's authorship is credible. The Italian composer Vincenzo Manfredini visited Russia twice: 1758-1769 and 1798-1799. By order of the St. Petersburg Court, he composed chants for the Orthodox Church
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Scognamiglio, Monica, Viviana Maresca, Adriana Basile, Severina Pacifico, Antonio Fiorentino, Maurizio Bruno, Natale Badalamenti, et al. "Phytochemical Characterization, Antioxidant, and Anti-Proliferative Activities of Wild and Cultivated Nigella damascena Species Collected in Sicily (Italy)." Antioxidants 13, no. 4 (March 27, 2024): 402. http://dx.doi.org/10.3390/antiox13040402.
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The use of Nigella damascena seeds in the culinary field or as aerial parts infusions in the pharmaceutical and cosmetic fields is widely reported. The biological activity of this plant, as demonstrated over the years, is closely related to its phytochemical content. This investigation focused on the comparative study of the same plants of N. damascena, one totally wild (WND), while the other two, one with white flowers (CWND) and the other with blue flowers (CBND), were subject to cultivation, irrigation, and manual weeding. Using the potential of 1D and 2D-NMR spectroscopy, coupled with MS/MS spectrometric studies, the three methanolic extracts of N. damascena were investigated. Chemical studies have highlighted the presence of triterpene saponin compounds and various glycosylated flavonoids. Finally, the in vitro antiproliferative and antioxidant activities of the three individual extracts were evaluated. The antiproliferative activity performed on U-937, HL-60, and MCF-7 tumor cell lines highlighted a greater anticancer effect of the CBND and CWND extracts compared to the data obtained using WND. The antioxidant activity, however, performed to quantify ROS generation is comparable among the extracts used.
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Bongomin, Felix, Tomaz Garcez, and David W. Denning. "Impact of high baseline Aspergillus-specific IgG levels on weight and quality-of-life outcomes of patients with chronic pulmonary aspergillosis." Medical Mycology 58, no. 7 (April 28, 2020): 1000–1004. http://dx.doi.org/10.1093/mmy/myaa026.
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Abstract This study aimed to evaluate the impact of quantitative baseline Aspergillus-specific immunoglobulin G (IgG) serum levels on weight changes of patients with chronic pulmonary aspergillosis (CPA) under antifungal treatment. We retrospectively reviewed data of patients diagnosed with CPA between April 2015 and March 2018 at the National Aspergillosis Centre (Manchester, UK). All patients were on continued antifungal treatment for 12 months. Data on Aspergillus-specific IgG levels, St George's quality of life (SGQoL) variables and weight at baseline, 6 months and 12 months were extracted. We defined a high serum Aspergillus-specific IgG as ≥ 200 mg/l (Group A) and low level < 200 mg/l (Group B). Forty-nine patients (37 male; 12 female), median age 65 years (range: 29–86) were studied. Overall, 33% (n = 16) of the patients were in Group A. The baseline characteristics between the two groups were similar. The median Charlson comorbidity index was 4 (range: 0–5) and 3 (range: 0–9) for Group A and Group B, respectively (P = .543). There was a sustained decline in median Aspergillus IgG levels from baseline, through 6 month to 12 months of continues therapy from 170 (range: 20–1110) to 121 (range: 20–1126), and finally 107 (15–937) mg/l, respectively (P < .001). Group A patients gained more weight at 6 months (9/15 [60%] vs. 7/33 [21%], P = .012) and at 12 months of treatment (9/15 [60%] vs. 7/33 [22%]), and more patients in Group B lost weight ((13/33 [41%] vs. 1/15 [7%]), P = .015). However, there was no difference in QoL outcomes across groups at 6 (P = .3) and 12 (P = .7) months. A very high Aspergillus IgG may confer a higher likelihood of weight gain as a key, objective marker of clinical response, if patients can tolerate 12 months of antifungal therapy.
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Ohmes, E. "Donald W. Rogers: Computational Chemistry using the PC, VCH Verlagsgesellschaft, New York, Weinheim, Basel, Cambridge, 1990, ISBN 3-52727-937-7, 224 Seiten, Preis: DM 98,-." Berichte der Bunsengesellschaft für physikalische Chemie 95, no. 10 (October 1991): 1306. http://dx.doi.org/10.1002/bbpc.19910951034.
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Carroll, J. L., and M. A. Bureau. "Decline in peripheral chemoreceptor excitatory stimulation during acute hypoxia in the lamb." Journal of Applied Physiology 63, no. 2 (August 1, 1987): 795–802. http://dx.doi.org/10.1152/jappl.1987.63.2.795.
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Chemoreceptor function was studied in eight 2- to 3-day-old unanesthetized lambs to sequentially assess hypoxic chemoreflex strength during an 18-min exposure to hypoxia [inspired O2 fraction (FIO2) = 0.08]. The immediate ventilatory (VE) drop in response to five breaths of pure O2 was measured at 3, 7, and 15 min during hypoxia. Each lamb was studied again at 10–11 days of age. At 2–3 days of age VE increased, with the onset of hypoxia, from 658 +/- 133 (SD) ml.min-1 X kg-1 to a peak of 1,124 +/- 177 ml.min-1 X kg-1. A dampening of the VE response then occurred, with a mean decline in VE of 319 ml.min-1 X kg-1 over the 18-min hypoxia period. Each pure O2 test (Dejours test) resulted in an abrupt fall in VE (delta VEDejours). This VE drop was 937 +/- 163, 868 +/- 244, and 707 +/- 120 ml.min-1 X kg-1 at 3, 7, and 15 min of hypoxia, respectively. Comparing the three O2 tests, delta VEDejours was significantly decreased by 15 min, indicating a loss of about one-fourth of the O2 chemoreflex drive during hypoxia. Testing at 10–11 days of age revealed a smaller VE decline during hypoxia. O2 tests at the beginning and end of the hypoxic period were not significantly different, indicating a smaller loss of hypoxic chemoreflex drive in the more mature animals.(ABSTRACT TRUNCATED AT 250 WORDS)
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Ivković, Ivana, Miroslav Novaković, Milan Veljić, Marija Mojsin, Milena Stevanović, Petar D. Marin, and Danka Bukvički. "Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity." Plants 10, no. 6 (May 26, 2021): 1063. http://dx.doi.org/10.3390/plants10061063.
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Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines. From the methylene-chloride/methanol extract of the liverwort Pellia endiviifolia, three bis-bibenzyls of the perrottetin type were isolated, namely perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E. The last two were found for the first time in this species. Their structures were resolved using 1D and 2D NMR, as well as by comparison with data in the literature. Cytotoxic activity of the isolated compounds was tested on three human leukemia cell lines, HL-60 (acute promyelocytic leukemia cells), U-937 (acute monocytic leukemia cells), and K-562 (human chronic myelogenous leukemia cells), as well as on human embryonal teratocarcinoma cell line (NT2/D1) and human glioblastoma cell lines A-172 and U-251, and compared to the previously isolated bis-bibenzyls (perrottetins) of similar structure. The isolated compounds exhibited modest activity against leukemia cells and significant activity against NT2/D1 and A-172. Overall, the most active cytotoxic compounds in this investigation were perrottetin E (1), isolated in this work from Pellia endiviifolia, and perrottetin F phenanthrene derivative (7), previously isolated from Lunularia cruciata and added for a comparison of their cytotoxic activity.
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Cornejo Báez, Walter, Belén Pérez Camborda, and Jesús Huamán Rojas. "Bienestar subjetivo, apego institucional y comportamientos antisocial-antiambiental-proambiental en estudiantes de educación." Horizonte de la Ciencia 6, no. 12 (July 1, 2017): 179. http://dx.doi.org/10.26490/uncp.horizonteciencia.2017.12.320.
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<p align="justify">Investigación correlacional que verifica la relación entre bienestar subjetivo, apego institucional y comportamientos antisocial-antiambiental y proamabiental en jóvenes. Participaron 937 estudiantes, varones y mujeres de los ciclos II al X de 7 Escuelas Académico Profesionales: Educación inicial, Educación física y psicomotricidad, Ciencias Naturales y Ambientales, Ciencias Matemáticas e Informática, Lenguas literatura y comunicacion, Filosofía, Ciencias sociales y relaciones humanas, cuya edad fluctúa entre 20 a 30 años, participantes varones (293) y mujeres (644) de la Facultad de Educación de la UNCP de la ciudad de Huancayo. Instrumentos: Escala de satisfacción con la vida de Diener (1985), Escala de apego a la institución de Hidalgo (2000) y Escala de rasgos de conducta antisocial, actos antiambientales y proambientales de Corral-Verdugo et al (2006), que se sometieron a confiabilidad por medio del alfa de Cronbach, el primero con r= .78, el segundo con r= .76 y el tercero con r= .78. Como prueba de hipótesis el estadístico no paramétrico de Spearman al 0.05 y 0.01 de significación; cuyos resultados evidenciaron que los estudiantes de educación poseen bienestar subjetivo y apego institucional bastante favorables y niveles bajos de comportamientos antisocial-antiambiental y alto de comportamiento proambiental.</p>
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ZOMER, T. P., V. ERASMUS, C. W. LOOMAN, A. TJON-A-TSIEN, E. F. VAN BEECK, J. M. DE GRAAF, A. H. E. VAN BEECK, J. H. RICHARDUS, and H. A. C. M. VOETEN. "A hand hygiene intervention to reduce infections in child daycare: a randomized controlled trial." Epidemiology and Infection 143, no. 12 (January 8, 2015): 2494–502. http://dx.doi.org/10.1017/s095026881400329x.
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SUMMARYInfections are common in children attending daycare centres (DCCs). We evaluated the effect of a hand hygiene (HH) intervention for caregivers on the incidence of gastrointestinal and respiratory infections in children. The intervention was evaluated in a two-arm cluster randomized controlled trial. Thirty-six DCCs received the intervention including HH products, training sessions, and posters/stickers. Thirty-five control DCCs continued usual practice. Incidence of episodes of diarrhoea and the common cold in children was monitored by parents during 6 months. Using multilevel Poisson regression, incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were obtained. Diarrhoeal incidence was monitored in 545 children for 91 937 days. During follow-up, the incidence was 3·0 episodes per child-year in intervention DCCs vs. 3·4 in control DCCs (IRR 0·90, 95% CI 0·73–1·11). Incidence of the common cold was monitored in 541 children for 91 373 days. During follow-up, the incidence was 8·2 episodes per child-year in intervention DCCs vs. 7·4 in control DCCs (IRR 1·07, 95% CI 0·97–1·19). In this study, no evidence for an effect of the intervention was demonstrated on the incidence of episodes of diarrhoea and the common cold.
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Khanal, H., DR Bhatta, BR Tiwari, and DR Joshi. "Seroprevalence of Hepatitis B among blood donors in Jhapa, Nepal." Sunsari Technical College Journal 1, no. 1 (September 16, 2013): 33–37. http://dx.doi.org/10.3126/stcj.v1i1.8659.
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Background: Blood donation saves life of millions. However unsafe transfusion is also putting blood receivers in risk of Hepatitis B infections and window period is potential cause of transmission. Objectives: The objective of the study was to find out the seroprevalence of hepatitis B among blood donors. Materials and Methods: During the study period from July 2008 to April 2009, a total of 2277 donated blood samples from Nepal Red Cross Society Jhapa Branch and Damak Sub-branch were analyzed for present of hepatitis B surface antigen (HBsAg) on serum by using Hepacard, a rapid diagnostic chromatographic test kit. Results: On the study HBsAg seroprevalence were 7 out of 1340 (0.52%) and 6 out of 937(0.64%) in Bhadrapur and Damak respectively. The Hepatitis B Virus (HBV) prevalence among male at Bhadrapur was found 7 out of 1172 (0.59%) and 6 at Damak out of 760 (0.79%) were positive. The overall seroprevalence of male blood donors in Jhapa district was 12 out of 1932 (0.62%). Among the 168 female blood donors only one female was seen positive at Bhadrapur with 0.59% of seroprevalence and overall seroprevalence of hepatitis B surface antigen among female in Jhapa district was 1 out of 345 (0.29%). Conclusion: Hepatitis B infection is a most important threat associated with unscreened blood donations. It.s a great importance to perform and confirm donated blood by sensitive and specific tests. It is essential to prevent the transmission of hepatitis B virus from blood donors. DOI: http://dx.doi.org/10.3126/stcj.v1i1.8659 Sunsari Technical College Journal Vol.1(1) 2012 33-37
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H. Alosaimi, Eid. "Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes." Bulletin of the Chemical Society of Ethiopia 38, no. 4 (April 30, 2024): 937–48. http://dx.doi.org/10.4314/bcse.v38i4.10.
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Three new metal complexes of ceftriaxone (cef), incorporating platinum(IV), gold(III), and ruthenium(III), were prepared. The complexes were prepared using a 1:2 molar ratio between ceftriaxone sodium salt (Na2cef) to AuCl3, PtCl4, and RuCl3 salts in methanol solvent. The as-synthesized complexes were characterized using microanalytical techniques for C, H, N, and S elements, magnetic and molar conductance measurements, as well as spectroscopic methods including FTIR, 1H NMR, and UV-Vis. The shape, morphology and size calculations have been examined using SEM, TEM, and X-ray diffraction data. The cef complexes were six-coordinate systems possessing a distorted octahedral geometry. Through the oxygen of both triazine and carboxylate moieties with the chemical formulae [Au(cef)2(Cl)(H2O)] (I), [Pt(cef)2(Cl)2] (II), and [Ru(cef)2(Cl)(H2O)] (III) the antibiotic cef acts as a bidentate ligand towards three metal ions. The newly created complexes demonstrated antibacterial activity showing efficacy in comparison to the cef sodium ligands. In vitro, antibacterial assays against specific microorganisms were evaluated to assess the antibacterial activities of the complexes. Cytotoxicity assays for cef complexes were conducted for HepG-2 and MCF-7 cell lines, representing human hepatocellular carcinoma and breast cancer, respectively. A value of 22.4 g and 26.2 g for 50% inhibitory concentration (IC50), respectively, for HepG-2 and MCF-7 were obtained for [Ru(cef)2(Cl)(H2O)] (III). KEY WORDS: Ceftriaxone sodium, Gold, Ruthenium, Platinum, Complexes, FTIR, IC50 Bull. Chem. Soc. Ethiop. 2024, 38(4), 937-948. DOI: https://dx.doi.org/10.4314/bcse.v38i4.10
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Inoue-Choi, Maki, Yesenia Ramirez, Ami Fukunaga, Charles E. Matthews, and Neal D. Freedman. "Association of Adherence to Healthy Lifestyle Recommendations With All-Cause and Cause-Specific Mortality Among Former Smokers." JAMA Network Open 5, no. 9 (September 22, 2022): e2232778. http://dx.doi.org/10.1001/jamanetworkopen.2022.32778.
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ImportanceThe benefits of smoking cessation are well known, but former smokers have a higher health risk than never smokers. The impact of former smokers’ engaging in other aspects of a healthy lifestyle is unclear.ObjectiveTo assess the association between adherence to evidence-based lifestyle recommendations and mortality among former smokers.Design, Setting, and ParticipantsThis prospective cohort study included 159 937 participants in the National Institutes of Health–AARP Diet and Health Study of older US adults who completed the baseline and risk factor questionnaires and self-identified as former smokers. Baseline questionnaires were mailed from 1995 to 1996. Data analysis was performed from November 2020 to November 2021.ExposuresAdherence to evidence-based lifestyle recommendations was scored for body weight (scores, 0-2), diet (scores, 0-3), physical activity (scores, 0-2), and alcohol intake (scores, 0-1) recommendations, with higher scores indicating better adherence. Individual lifestyle adherence scores were summed to make a total adherence score (scores, 0-8).Main Outcomes and MeasuresThe primary outcomes were all-cause and cause-specific mortality through December 31, 2019, with a mean (SD) follow-up of 18.9 (6.3) years. Hazard ratios (HRs) and 95% CIs were computed using a multivariable Cox proportional hazards regression model.ResultsAmong 159 937 former smokers (mean [SD] age, 62.6 [5.2] years; 106 912 [66.9%] male; 149 742 [93.6%] White), 86 127 deaths occurred. A higher total adherence score was associated with lower all-cause mortality (HR per unit increase, 0.95; 95% CI, 0.94-0.95). Compared with the lowest total adherence score category (scores, 0-2), the HRs for all-cause mortality were 0.88 (95% CI, 0.86-0.90) for scores of 3 to 4, 0.80 (95% CI, 0.79-0.82) for scores of 5 to 6, and 0.73 (95% CI, 0.71-0.75) for scores of 7 to 8. Associations were observed regardless of health status, comorbid conditions, the number of cigarettes participants used to smoke per day, years since cessation, and age at smoking initiation. When examined individually, the HRs for highest vs lowest adherence score were 0.86 (95% CI, 0.84-0.88) for body weight, 0.91 (95% CI, 0.90-0.93) for diet, 0.83 (95% CI, 0.81-0.85) for physical activity, and 0.96 (95% CI, 0.94-0.97) for alcohol intake recommendations. Participants with a higher total adherence score also had a lower risk of mortality from cancer, cardiovascular disease, and respiratory disease.Conclusions and RelevanceIn a large US cohort of former smokers, better adherence to healthy lifestyle recommendations was associated with lower mortality risk. These results provide evidence that former smokers may benefit from adhering to lifestyle recommendations, as do other groups.
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Rius, C., and P. Aller. "Vimentin expression as a late event in the in vitro differentiation of human promonocytic cells." Journal of Cell Science 101, no. 2 (February 1, 1992): 395–401. http://dx.doi.org/10.1242/jcs.101.2.395.
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The administration of either 12-O-tetradecanoyl phorbol-13-acetate (TPA, 3 × 10(−8) M), sodium butyrate (SB, 10(−3) M), N6,2′-O-dibutyryladenosine-3′:5′-cyclic monophosphate (dbcAMP, 10(−3) M), cytosine arabinoside (ara-C, 10(−7) M), amsacrine (mAMSA, 10(−7) M) or retinoic acid (RA, 10(−6) M) inhibits the growth activity of human promonocytic U-937 cells, by arresting them at G1 or at the G1/S border (SB, RA, ara-C), at G2 (mAMSA) or at G1 and G2 (dbcAMP). All these agents trigger cell differentiation, as proved by the increased expression of the maturation-associated CD11b and CD11c surface antigens, and induce the expression of the vimentin gene at both the protein and the mRNA levels. TPA, SB and dbcAMP behave as “early” inducers, in the sense that vimentin mRNA levels are rapidly increased (hour 6) upon drug administration. In contrast, mAMSA and RA behave as “late” inducers, since they do not increase vimentin mRNA levels until 48 to 72 hours, following the stimulation of surface antigen expression. The action of RA is characterized by an initial inhibition period, in which the basal level of vimentin mRNA is abolished (hour 24). Nevertheless, this RNA is later re-induced, to reach at 72 hours higher levels than in untreated cells. Moreover, RA is capable of delaying the early induction of vimentin expression caused by TPA and SB, without affecting the normal expression of differentiation markers. Taken together, these results strongly suggest that vimentin expression is not required at the initial stages of promonocytic cell differentiation, although it could play a role at an advanced stage.
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Aragón-Muriel, Alberto, Yamil Liscano, Yulieth Upegui, Sara M. Robledo, María Teresa Ramírez-Apan, David Morales-Morales, Jose Oñate-Garzón, and Dorian Polo-Cerón. "In Vitro Evaluation of the Potential Pharmacological Activity and Molecular Targets of New Benzimidazole-Based Schiff Base Metal Complexes." Antibiotics 10, no. 6 (June 16, 2021): 728. http://dx.doi.org/10.3390/antibiotics10060728.
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Metal-based drugs, including lanthanide complexes, have been extremely effective in clinical treatments against various diseases and have raised major interest in recent decades. Hence, in this work, a series of lanthanum (III) and cerium (III) complexes, including Schiff base ligands derived from (1H-benzimidazol-2-yl)aniline, salicylaldehyde, and 2,4-dihydroxybenzaldehyde were synthesized and characterized using different spectroscopic methods. Besides their cytotoxic activities, they were examined in human U-937 cells, primate kidney non-cancerous COS-7, and six other, different human tumor cell lines: U251, PC-3, K562, HCT-15, MCF-7, and SK-LU-1. In addition, the synthesized compounds were screened for in vitro antiparasitic activity against Leishmania braziliensis, Plasmodium falciparum, and Trypanosoma cruzi. Additionally, antibacterial activities were examined against two Gram-positive strains (S. aureus ATCC® 25923, L. monocytogenes ATCC® 19115) and two Gram-negative strains (E. coli ATCC® 25922, P. aeruginosa ATCC® 27583) using the microdilution method. The lanthanide complexes generally exhibited increased biological activity compared with the free Schiff base ligands. Interactions between the tested compounds and model membranes were examined using differential scanning calorimetry (DSC), and interactions with calf thymus DNA (CT-DNA) were investigated by ultraviolet (UV) absorption. Molecular docking studies were performed using leishmanin (1LML), cruzain (4PI3), P. falciparum alpha-tubulin (GenBank sequence CAA34101 [453 aa]), and S.aureus penicillin-binding protein 2a (PBP2A; 5M18) as the protein receptors. The results lead to the conclusion that the synthesized compounds exhibited a notable effect on model membranes imitating mammalian and bacterial membranes and rolled along DNA strands through groove interactions. Interactions between the compounds and studied receptors depended primarily on ligand structures in the molecular docking study.
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Kampf, Anthony R., Gerhard Möhn, and Chi Ma. "Désorite, Pb2(Fe3+6Zn)O2(PO4)4(OH)8, a New Phosphate Mineral Isotypic with Jamesite." Minerals 14, no. 2 (February 6, 2024): 175. http://dx.doi.org/10.3390/min14020175.
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The new mineral désorite, Pb2(Fe3+6Zn)O2(PO4)4(OH)8, is a secondary oxidation-zone mineral discovered on the dumps of the Schöne Aussicht mine, Dernbach, Westerwaldkreis, Rhineland-Palatinate, Germany. The crystals are irregular blades up to about 0.25 mm long, occurring in subparallel and radial aggregates. Désorite is brownish red. It has an orange streak, adamantine luster, brittle tenacity, splintery and curved fracture and two cleavages: {021¯} perfect and {001} good. It has a hardness (Mohs) of about 3 and is nonfluorescent in both long- and short-wave ultraviolet illumination. The calculated density is 4.633 g/cm3. Optically, crystals are biaxial (+) with α = 2.00(1), β = 2.02(calc) and γ = 2.10(calc) (white light). The 2V is 54(2)° and the optical orientation is Y ~⊥{021¯}, X ∧ a ≈ 13°. The mineral is pleochroic: X yellow brown, Y red brown, Z red brown; X < Y ≈ Z. The empirical formula from electron microprobe analysis is Pb1.93(Zn0.50Fe3+6.29☐0.21)Σ7.00(P3.90As0.10)Σ4.00O26H8.28. Désorite is triclinic, space group P1¯; the unit-cell parameters are a = 5.4389(7), b = 9.3242(13), c = 10.0927(12) Å, α = 109.024(8), β = 90.521(6), γ = 97.588(7)°, V = 478.90(11) Å3 and Z = 1. Désorite has a framework structure (R1 = 0.0487 for 937 I > 2σI reflections) assembled from Fe3+O6 octahedra and PO4 tetrahedra, with Pb occupying cavities in the framework. The Fe3+O6 octahedra in the framework occur in edge-sharing chains, edge-sharing trimers and individual octahedra, all sharing corners with each other and with PO4 tetrahedra. Désorite is isostructural with jamesite and lulzacite.
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Coringrato, Mauro, Irene Vera, Alejandra Segura, Margarita Jaled, and Fernando Sebastiani. "¿Cuán segura es la dermatología quirúrgica?" Dermatología Argentina 26, no. 1 (March 2, 2020): 26–31. http://dx.doi.org/10.47196/da.v26i1.2065.
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Antecedentes: Aunque las complicaciones globales en la dermatología quirúrgica referidas en la bibliografía mundial son bajas (1,64-4,58%), las publicaciones regionales con datos prospectivos sobre ellas son escasas y, a nivel nacional, inexistentes. Objetivos: Estimar la incidencia de complicaciones intraquirúrgicas (CI) y posquirúrgicas (CP) en los procedimientos de cirugía dermatológica y caracterizarlas en el ámbito de una sala de procedimientos de un hospital de referencia de la Ciudad Autónoma de Buenos Aires. Diseño: Trabajo de investigación descriptivo, prospectivo, observacional y longitudinal. Materiales y métodos: Se recolectó información demográfica del paciente y operativa en el momento del procedimiento quirúrgico. Se clasificaron las complicaciones quirúrgicas que se presentaron hasta un mes posterior al procedimiento en los pacientes intervenidos en la sección de Dermatología Quirúrgica del Hospital F. J. Muñiz, en el período comprendido entre febrero de 2015 y marzo de 2018. Resultados: Se halló una incidencia de 0% (IC95%: 0 a 0,4)para las CI y de 4,4% (IC95%: 3,2 a 5,9) para las CP en una serie de 765 pacientes (937 procedimientos). La CP más frecuente fue dehiscencia (68%), seguida de infección (16%), variantes de sangrado (9%) y necrosis (7%). Ninguna fue grave ni incluyó muerte, hospitalización o secuelas permanentes. Conclusiones: La dermatología quirúrgica en el ámbito de una sala de procedimientos es segura y el porcentaje de complicaciones es bajo comparable a lo publicado en la bibliografía internacional.
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Vu, Milan, Nick Kassouf, and Sandra Appiah. "Betulinic Acid–Doxorubicin-Drug Combination Induced Apoptotic Death via ROS Stimulation in a Relapsed AML MOLM-13 Cell Model." Antioxidants 10, no. 9 (September 14, 2021): 1456. http://dx.doi.org/10.3390/antiox10091456.
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In this study, cell death regulation and induction in AML cell line from a relapsed MLL-rearranged cell model (MOLM-13) was investigated with doxorubin (Dox) and betulinic acid (BetA), singly and in combination. CyQUANT Direct® and Annexin V/propidium iodide double staining were used to measure the cytotoxic and cell death induction effects of the compounds, respectively. Reactive oxygen species (ROS) generation was measured using 2′,7′-dichlorofluorescin diacetate staining. Expressions of proteins and genes were examined by Western blot and reverse transcription polymerase chain reaction analysis, respectively. BetA (20 μM) and Dox (1 μM) indicated a synergistic growth inhibitory effect on MOLM-13 cells. The combined drug caused more cells to reside in irreversible late apoptotic stage compared to the single treatments (p < 0.05). Elevation in ROS may be the synergistic mechanism involved in MOLM-13 cell death since ROS can directly disrupt mitochondrial activity. In contrast, in leukaemic U-937 cells, the combination treatments attenuated Dox-induced cell death. Dox and the drug combination selectively reduced (p < 0.05) a recently reported anti-apoptotic Bcl-2 protein isoform p15-20-Bcl-2 in MOLM-13 by our group, without affecting the usually reported p26-Bcl-2-α. Further studies using known inhibitors of apoptosis are required to confirm the potential of Dox-BetA combination to modulate these pathways.
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Riasat, Nimra, and Dr Zaqia Bnao. "Development and Psychometric Properties of Adult Ostracism Scale." Vol 4 Issue 6 4, no. 6 (September 3, 2022): 62–69. http://dx.doi.org/10.33411/ijist/2022040607.
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The main objective of the current research was the development of the ostracism scale in the Urdu language to shed the light on this invisible harassment and abuse which is the most ignored part of society yet a very common method to exclude people from social groups. A total of 40 items developed through an adequate process with the help of William’s need and threat model. A sample of 200 participants in the age range of 18 to 40 years was selected for data collection through a simple random sampling technique. After analysis, the sample adequacy was 0.915 with 4 factors including self-esteem, control, meaningful existence and belonging which are the four fundamental needs of humans. CFA is .903 with the removal of 18 items in the scale and sample adequacy of the remaining 22 items of the scale is .924 with reliability of α = .937. 7 items subscale “self-esteem” reliability value is α = .866, 6 items subscale “control” reliability is 8.25, 5 items subscale “meaningful existence” reliability value is α = 844 and 4 items subscale “belonging” reliability value is α = .704. In Pakistani culture, it is very common to exclude someone without giving attention to the psychological factors the excluded person will face. This research will provide a direction to further research and awareness about ostracism which is rarely known by individuals but yet faces every day.