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Published: 10 December 2022
Last updated: 29 January 2023

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1

J, Wald Nicholas, Baron John, and Great Britain. Dept. of Health., eds. Smoking and hormone-related disorders. Oxford: Oxford University Press, 1990.

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2

Chemo fog: Cancer chemotherapy-related cognitive impairment. New York, N.Y: Springer Science+Business Media, 2010.

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3

Internal malignancy and the skin: Paraneoplastic and cancer treatment-related cutaneous disorders. Philadelphia, Pa: Saunders, 2008.

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4

Peter, Burckhardt, ed. Disodium pamidronate (APD) in the treatment of malignancy-related disorders. Toronto: Huber, 1989.

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5

Alcohol and cancer. New York: Springer, 2011.

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6

Congress, European Society for Medical Oncology. Disodium pamidronate (APD) in the treatment of malignancy-related disorders: An international symposium held during the 13th Congress of the European Society for Medical Oncology (ESMO), Lugano, Switzerland, October 1988. Toronto: Hogrefe & Huber, 1990.

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7

Adolescent health sourcebook: Basic consumer health information about adolescent growth and development, puberty, sexuality, reproductive health, and physical, emotional, social, and mental health concerns of teens and their parents, including facts about nutrition, physical activity, weight management, acne, allergies, cancer, diabetes, growth disorders, juvenile arthritis, infections, substance abuse, and more; along with information about adolescent safety concerns, youth violence, a glossary of related terms, and a directory of resources. 3rd ed. Detroit, MI: Omnigraphics, 2010.

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8

Raffa, Robert B., and Ronald J. Tallarida. Chemo Fog: Cancer Chemotherapy-Related Cognitive Impairment. Springer, 2016.

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9

Raffa, Robert B., and Ronald J. Tallarida. Chemo Fog: Cancer Chemotherapy-Related Cognitive Impairment. Springer, 2011.

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10

Kumar, Vinod, Pranela Rameshwar, and Karl L. Mettinger. Exosomes, Stem Cells and MicroRNA: Aging, Cancer and Age Related Disorders. Springer, 2018.

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11

Exosomes, Stem Cells and MicroRNA: Aging, Cancer and Age Related Disorders. Springer, 2018.

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12

Zakhari, Samir, Vasilis Vasiliou, and Q. Max Guo. Alcohol and Cancer. Springer, 2011.

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13

Zakhari, Samir, Vasilis Vasiliou, and Q. Max Guo. Alcohol and Cancer. Springer New York, 2014.

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14

Bijvoet, O. L. M. Osteoclast Inhibition in the Management of Malignancy-Related Bone Disorders: An International Symposium Held During the 15th International Cancer Co. Hogrefe & Huber Pub, 1992.

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15

(Editor), R. A. Weiss, ed. Cancer, HIV And AIDS (Cancer Surveys, Vol 10) (Cancer Surveys, Vol 10). Cold Spring Harbor Laboratory Pr, 1991.

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16

Sutton, Amy L. Blood And Circulatory Disorders Sourcebook: Basic Consumer Health Information About The Blood And Circulatory System And Related Disorders, Such as Anemia ... Diseases, Cancer o (Health Reference Series). 2nd ed. Omnigraphics, 2005.

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17

Seitz, Helmut K., Samir Zakhari, Vasilis Vasiliou, and Lopa Mishra. Alcohol and Cancer: Proceedings of the Third International Conference. Springer, 2018.

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18

Seitz, Helmut K., Samir Zakhari, Vasilis Vasiliou, and Lopa Mishra. Alcohol and Cancer: Proceedings of the Third International Conference. Springer, 2019.

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19

Maria, Bijvoet Olav Leonardus, Lipton Allan, and International Cancer Congress (15th : 1990 : Hamburg, Germany), eds. Osteoclast inhibition in the management of malignancy-related bone disorders: An international symposium held during the 15th International Cancer Congress, Hamburg, Germany, August 1990. Seattle: Hogrefe & Huber, 1993.

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20

W, Jaffe Harold, Beral V, Weiss Robin, and Imperial Cancer Research Fund (Great Britain), eds. Cancer, HIV, and AIDS. New York: Cold Spring Harbor Laboratory Press, 1991.

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21

Probasco, John C. Paraneoplastic Neurological Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0090.

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Paraneoplastic neurological disorders (PNDs) are estimated to affect approximately 0.01% of all patients with cancer. The majority of PNDs are thought to be the byproduct of immune-mediated processes directed against tumor-related antigens, processes which are sometimes effective against a systemic cancer. The inciting cancer is often asymptomatic or occult, with patients presenting to the neurologist with a variety of neurological symptoms and signs depending on the area(s) of the central, peripheral, and autonomic nervous system involved. The diagnosis of a PND is reserved for patients with histologically proven cancer; however, clinical presentation and diagnostic test results may make the diagnosis of a PND highly probable in the absence of the diagnosis of a cancer.
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22

L, Sutton Amy, ed. Blood and circulatory disorders sourcebook: Basic consumer health information about the blood and circulatory system and related disorders, such as anemia and other henoglobin diseases, cancer of the blood and associated bone marrow disorders, clotting and bleeding problems, and conditions that affect the veins, blood vessels, and arteries ... 2nd ed. Detroit, MI: Omnigraphics, 2005.

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23

J, Judd Sandra, ed. Men's health concerns sourcebook: Basic consumer health information about wellness in men and gender-related differences in health, including facts about heart disease, cancer, traumatic injury, other leading causes of death in men, reproductive concerns, sexual dysfunction, disorders of the prostate, penis, and testes, sex-linked genetic disorders, and other medical and mental concerns of men ; along with statistical data, a glossary of related terms, and a directory of resources for additional information. 3rd ed. Detroit, MI: Omnigraphics, Inc., 2009.

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24

J, Judd Sandra, ed. Men's health concerns sourcebook: Basic consumer health information about wellness in men and gender-related differences in health, including facts about heart disease, cancer, traumatic injury, other leading causes of death in men, reproductive concerns, sexual dysfunction, disorders of the prostate, penis, and testes, sex-linked genetic disorders, and other medical and mental concerns of men ; along with statistical data, a glossary of related terms, and a directory of resources for additional information. 3rd ed. Detroit, MI: Omnigraphics, Inc., 2009.

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25

Brennfleck, Shannon Joyce, ed. Liver disorders sourcebook: Basic consumer health information about the liver and how it works; liver diseases, including cancer, cirrhosis, hepatitis, and toxic and drug related diseases; tips for maintaining a healthy liver; laboratory tests, radiology tests, and facts about liver transplantation; along with a section on support groups, a glossary, and resources listings. Detroit, Mich: Omnigraphics, 2000.

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26

Sills, Irene N., and Martin M. Fisher, eds. AM:STARs: Advances in the Treatment of Endocrine Disorders in Adolescents, Vol. 26, No. 2. American Academy of Pediatrics, 2015. http://dx.doi.org/10.1542/9781581109498.

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There are a series of endocrine disorders that can affect adolescents, some of which are related to growth and development and others that can occur at any age but may have specific implication for the adolescent age group. This issue provides a comprehensive update of endocrine issues seen in adolescents, with a focus on recent advances in diagnosis and treatment. Contents in Advances in the Treatment of Endocrine Disorders in Adolescents include Thyroid Disorders Update on Diabetes Melitus Disorders of Growth and Puberty Bone Health in Adolescents Polycystic Ovarian Syndrome Adrenal Disorders Lipid Disorders Endocrine Disorders in Pregnancy Endocrine Abnormalities in Patients with Eating Disorders Turner syndrome and Klinefelter Syndrome Disorders of Sex Development Endocrine Disorders in Adolescent Cancer Survivors
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27

Brennfleck, Shannon Joyce, ed. Pain sourcebook: Basic consumer health information about acute and chronic pain, including nerve pain, bone pain, muscle pain, cancer pain, and disorders characterized by pain, such as arthritis, temporomandibular muscle and joint (tmj) disorder, carpal tunnel syndrome, headaches, heartburn, sciatica, and shingles, and facts about diagnostic tests and treatment options for pain, including over-the-counter and prescription drugs, physical rehabilitation, injection and infusion therapies, implantable technologies, and complementary medicine; along with tips for living with pain, a glossary of related terms, and a directory of additional resources. 3rd ed. Detroit: Omnigraphics, 2008.

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28

Watson, Max, Caroline Lucas, Andrew Hoy, and Jo Wells. Palliative haematological aspects. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199234356.003.0023.

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This chapter on palliative haematological aspects covers anaemia in chronic disorders, blood transfusion, erythropoietin, bleeding and haemorrhage, blood products, bleeding directly related to cancer, haemoptysis, haematemesis, rectal bleeding, haematuria, massive terminal haemorrhage, thromboembolism, deep vein thrombosis (DVT), pulmonary embolism (PE), chronic venous thrombosis, warfarin in patients with cancer, and developing a good relation with haematology colleagues.
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29

Adam, Sheila, Sue Osborne, and John Welch. The immune system and the immunocompromised patient. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199696260.003.0013.

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This chapter discusses the physiology of the immune system and its related disorders in the critically ill patient. The causes, complications, and management of the immunocompromised patient is discussed at length, detailing the specific nursing management. It also discusses the management of autoimmune disease such as Wegener's granulomatosis and rheumatoid arthritis, and hypersensitivity reactions such as drug allergy and anaphylactic reaction. Cancer is explained in detail, including its complications, specific therapies such as stem cell transplant, and the role of the cancer patient within critical care.
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30

Riojas-Rodríguez, Horacio, Isabelle Romieu, and Mauricio Hernández-Ávila. Air Pollution. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0018.

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This chapter describes the adverse effects of both outdoor air pollution and indoor air pollution. Various ambient air pollutants are described as well as their adverse health effects, including acute and chronic respiratory disorders, cardiac disorders, cerebrovascular disease, and cancer. A section deals with National Ambient Air Quality Standards of the Environmental Protection Agency for particulate matter, sulfur dioxide, ozone, oxides of nitrogen, and carbon monoxide. Another section describes exposure assessment. The chapter also describes various measures to control hazardous air pollutants and prevent disorders related to air pollution. In addition, a section features indoor air pollution, including pollution due to burning of biomass for cooking and heat.
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31

Jolly, Elaine, Andrew Fry, and Afzal Chaudhry, eds. Gastroenterology and hepatology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199230457.003.0009.

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Chapter 9 covers the basic science and clinical topics relating to gastroenterology and hepatology which trainees are required to learn as part of their basic training and demonstrate in the MRCP. It covers basic science, gastrointestinal investigation, malabsorption and malnutrition, inflammatory bowel disease, acute upper gastrointestinal haemorrhage, lower gastrointestinal bleeding and related disorders, gastrointestinal infections, gastrointestinal cancer, miscellaneous gastrointestinal problems, normal liver and biliary function, variceal disease, hepatic tumours, acute (fulminant) liver failure, haemochromatosis, Wilson disease (hepatolenticular degeneration), Alpha-1 antitrypsin deficiency, alcohol-induced liver disease, hepatitis, biliary diseases, and non-alcoholic fatty liver disease.
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32

Chung, Melissa, and Warren Lo. Pediatric Stroke. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0106.

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A variety of congenital and genetic disorders not seen frequently in adults may be responsible for stroke in infants and children. Stroke in newborn infants is as common as stroke in elderly individuals due to risk factor such as congenital heart disease, thrombophilia associated with polycythemia in neonates and genetic disorders, high estrogen impact from the mother during pregnancy, and inflammation due to infections. Stroke can also be caused by genetic disorders such as Ehleers-Danlos syndrome, Sturge-Weber syndrome, and vasculopathies such as lupus and fibromuscular dysplasia. Arterial dissection may be related to trauma and athletic injuries. Some drugs used to treat cancer such as asparaginase can also cause strokes, and infants and children can also present with venous sinus thrombosis associated with critical illness and dehydration.
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33

Stoner, Marie. Hypnosis and Biofeedback as Prototypes of Mind–Body Medicine. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0011.

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Hypnotizability is a strong moderator for treatment outcome in patients with psychiatric disorders. Hypnosis is able to reduce distress and pain in short procedures and has been particularly useful in cancer procedures. Gut-directed hypnotherapy for irritable bowel syndrome has shown substantial results for structured short-term scripted treatment. Biofeedback for hypertension is successful when clinical practice guidelines identifying patient characteristics are followed. Heart rate variability biofeedback shows promise as a technique to directly target self-regulatory mechanisms. Innovative use of real-time functional magnetic resonance imaging neurofeedback is showing promise for altering neural patterns underlying diverse disorders such as clinical depression and chronic pain. Obsessive-compulsive disorder and eating disorders patients may be selectively responsive to hypnotic suggestion. This chapter reviews the basis of hypnosis and related approaches to the management of patients with psychiatric conditions.
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34

Merims, Sharon, and Michal Lotem. Skin problems in oncology. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0144.

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The skin may be adversely affected by any serious medical illness, often as a secondary process related to infection, trauma, nutritional deficiencies, and other factors. Disease-specific skin involvement occurs commonly in some conditions, and is best characterized in cancer. Skin of the patient with advanced cancer is unique compared to other organs of the body. While the sequela of metastatic spread to internal organs often is replacement of normal tissue and resultant organ failure, widespread replacement of skin with a neoplasm is uncommon. Yet, even a local disruption of skin integrity can cause deterioration in the quality of life, debilitation, and even mortality. Other aspects of neoplastic disorders affecting the skin discussed in this chapter include accumulation of abnormally produced metabolites, adverse effects to treatment, and paraneoplastic syndromes. It is important to give dermatological aspects of disease their appropriate attention, because these can be the ones that may be dealt with efficiently and improve the patient’s quality of life.
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35

Grassi, Luigi, Maria Giulia Nanni, and Rosangela Caruso. Psychotherapeutic interventions. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198806677.003.0010.

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Psychotherapy is an integrative and integrated part of modern patient/relation-centered care in the advanced and terminal phases of physical illness. Psychiatric disorders (e.g. depressive spectrum, stress-related, and anxiety disorders), other clinically significant psychosocial conditions (e.g. demoralization, existential pain) and interpersonal, psychological, and spiritual needs have to be addressed by psychological intervention. Supportive-Expressive Group Psychotherapy (SEGT), Meaning-Centered Psychotherapy (MCT), Managing Cancer and Living Meaningfully Therapy (CALM), cognitive-existential therapy, dignity therapy (DT) and other psychotherapeutic interventions have been developed over the last 40 years. These treatments have proved to be effective in increasing the patients’ sense of dignity, purpose, and meaning, and to reduce demoralization, anxiety, and existential distress at the end of life. Also Family Focused Grief Therapy (FFGT) and grief therapy have shown to be effective in overcoming anxiety, depression, and complicated grief symptoms both before and after loss. Psychotherapy should thus be considered a mandatory ingredient of palliative care.
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36

Axelsson, John, Mikael Sallinen, Tina Sundelin, and Göran Kecklund. Sleep and shift work. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198778240.003.0020.

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The rapid development of modern society has resulted in a growing population of workers that have to work around the clock. However, working at different times comes at a cost. Night work is related to short sleep, increased fatigue, falling asleep at work, worse performance, and increased risk for injuries and accidents. Early morning work is also affected, but to a lesser extent. Working shifts can carry long-term health consequences such as an increased risk for developing cardiovascular disease, endocrine and metabolic disturbances, cancer, and gastrointestinal disorders. However, the evidence is far from immaculate and there is a need for studies with better measures of exposure and more knowledge regarding why there are such large individual differences in tolerance to shift work. In addition, the negative consequences of shift work can be reduced by both organizational and individual countermeasures. The interactive effects of combining several countermeasures seem especially promising.
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37

Bafadhel, Mona. Prevention of respiratory disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0344.

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The prevention of disease at a population health level rather than an individual health level is aimed at reducing causes of ‘preventable’ death and, under the auspices of public health and epidemiology, is an integral part of primary, secondary, and tertiary care. Classification of death is usually according to the type of primary disease or injury. However, there are a number of recognized risk factors for death, and modifications in behaviour or risk factors can substantially reduce preventable causes of death and the associated healthcare and economic burden of chronic disease management. According to the WHO, hundreds of millions of people from infancy to old age suffer from preventable chronic respiratory diseases, there are over four million deaths annually from preventable respiratory diseases, and common respiratory disorders (e.g. lower respiratory tract infections, chronic obstructive pulmonary disease, lung cancer, and tuberculosis) account for approximately 20% of all deaths worldwide. This chapter discusses the prevention of respiratory disease, covering diseases associated with smoking (one of the biggest risk factors associated with preventable deaths), air pollution, and other lifestyle factors associated with respiratory disease; changes in legislation concerning smoking and work-related respiratory disease; and, finally, the prevention of respiratory diseases through the use of immunization and screening tools.
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38

Wójcik-Gładysz, Anna. Ghrelin – hormone with many faces. Central regulation and therapy. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_awg_2020.

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Discovered in 1999, ghrelin, is one of the peptides co-creating the hypothalamicgastrointestinal axis, otherwise known as the brain-gut axis. Ghrelin participates in many physiological processes and spectrum of its activity is still being discovered. This 28 amino acid peptide ‒ a product of the ghrl gene, was found in all vertebrates and is synthesized and secreted mainly from enteroendocrine X/A cells located in the gastric mucosa of the stomach. Expression of the ghrelin receptor has been found in many nuclei of the hypothalamus involved in appetite regulation. Therefore it’s presumed that ghrelin is one of the crucial hormones deciphering the energy status required for the maintenance of organism homeostasis. Ghrelin acts as a signal of starvation or energy insufficiency and its level in plasma is reduced after the meal. Neuropeptide Y (NPY) and agouti-related peptide (AgRP; NPY/AgRP) neurons located in the arcuate nucleus (ARC) area are the main target of ghrelin in the hypothalamus. This subpopulation of neurons is indispensable for inducing orexigenic action of ghrelin. Moreover ghrelin acting as a neurohormone, mainly in the hypothalamus area, plays an important role in the regulation of growth and reproduction processes. Indeed, ghrelin action on reproductive processes has been observed in the systemic effects exerted at both hypothalamus-pituitary and gonadal levels. Similarly the GH-releasing ghrelin action was observed both on the hypothalamus level and directly on the somatotrophic cells in the pituitary and this dose-related GH releasing activity was found in in vitro as well as in in vivo experiments. In recent years, numerous studies revealed that ghrelin potentially takes part in the treatment of diseases associated with serious disturbances in the organism energy balance and/or functioning of the gastrointestinal tract. It was underlined that ghrelin may be a hormone with a broad spectrum of therapeutic effect on obesity and anorexia nervosa, as well as may also have protective effect on neurodegenerative diseases, inflammatory disorders or functional changes in the body caused by cancers. In overall, ghrelin treatment has been tested in over 100 preclinical studies with healthy volunteers as well as patients with various types of cancer, eating disorders such as anorexia nervosa and bulimia nervosa. It was observed that ghrelin has an excellent clinical safety profile and emerging side effects occurred only in 3–10% of patients and did not constitute a sufficient premise to discontinue the therapy. In general, it can be concluded that ghrelin may be sufficiently used as a prescription drug.
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