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1

Ashe, Leah M. "Towards a dignified food security? : discourses of dignity, development and culture in New York City and Bogotá." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91416/.

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In light of a severe, changing and globally implicative New Food Equation marked perhaps above all else by the dynamics of a new, bimodal food insecurity and the simultaneous rising importance of cities, new approaches to address food security at urban scales suggest promise. But as such efforts are relatively new, the discourses and activities of urban actors are understood to only a limited extent. Moreover, while attention to food security per se is robust and growing, attention to the discursive and narrative dimensions that ultimately construct both the real nutritional achievements and the real experiential implications of such policy is not. In this research, I apply analytical methods informed by the interpretive, critical and ethnographic traditions to understand (some of) the cultural, ideological and philosophical particularities of these new dynamics and contexts, examining the cases of two large cities in the North and South, New York City and Bogotá. Tandem to the empirical work, I explore the philosophical tenets that ground food security efforts in the two studied cities and more generally, and I finally settle upon the purposefully normative appeal for motion towards a new concept: dignified food security.
2

Gbajumo-Sheriff, Mariam. "Does work-life balance have a cultural face? : understanding the work-life interface of Nigerian working mothers." Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/91316/.

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With the increase in the number of women working in the formal economy, there has been a growing literature on women handling multiple roles arising from work and the home. Currently there is a gap in the literature about the activities of working mothers in emerging economies, with theories and most findings concentrated on studies in advanced economies. This study therefore intends to fill part of the gap in the literature by investigating the lives of working mothers in the oil and gas sector in Nigeria, with a view of understanding their challenges, pains and gains as they navigate between the home and work spheres. This research adopted a qualitative approach through the administration of semi-structured interviews to working mothers, supervisors and Human Resources practitioners. Using the Greenhaus and Beutell’s (1985) sources of conflict model, this study explored the work and family lives of working mothers in Nigeria, thereby giving a detailed view of the time, strain and behaviour-based conflict they experience, as well as appropriate coping strategies that have been put in place to mitigate the effects of such conflicts. Findings complement earlier studies on work and family in Africa focusing on the experience of strain by working mothers in Nigeria. However, analysis from this study suggests that some of these stress-related conflicts were caused by the prevalent work culture of presenteeism. In comparing evidence of a more equal sharing of domestic tasks between couples in advanced economies, the embrace of equal sharing of housework by men and a demand for such by women in Nigeria is rather limited and slow. A striking difference on the strategies employed by working mothers in the west and in Nigeria is that what working mothers in Nigeria lose by way of government support, they gain in the form of family support.
3

Smyrnaios, Ioannis. "The correlation of technological and stylistic changes, and society, in the production of attic geometric and orientalising finewares." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91116/.

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This thesis investigates stylistic and technological changes in the production of Attic Geometric and Orientalising finewares (c. 900 – 620 BC), and their relationship with society. The transition from the abstract motifs of the Early and Middle Geometric styles to the figurative representations of the Late Geometric and Orientalising styles are examined in conjunction with the technological advances in the ceramic chaîne opératoire, and the social changes that characterise these periods. According to previous studies, the social developments in the Athenian polis between the 9th and 7th centuries BC left traces in the archaeological record suggesting competition among different elite groups. This social competition was expressed through funerary rites, which were subject to continuous changes all across the Attic Early Iron Age. The consumption of decorated finewares in such rites and other important social occasions demarcated the social position of the consumers/users of fine decorated pottery, while ceramic styles adapted to accommodate the changing nature of social demands. An important manifestation of stylistic change was the dominance of the figurative style in pottery decoration during the beginning of the Late Geometric period (c.760 BC). The original hypothesis of this research project is based on the fact that decoration was only part of the total production sequence of Attic Geometric and Orientalising pottery; therefore, it could be likely that the social changes noted during these periods triggered broader advances in ceramic technologies employed for the production of such finewares. This thesis moves away from traditional stylistic approaches and employs a technological approach based on the chaîne opératoire theory in order to explore the behaviour of Attic Early Iron Age potters and their response towards changing consumption demands during an era of significant social transformations.
4

Wang, Zhongnan. "Tribological investigation for next-generation polymeric micro-systems." Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/91016/.

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The development of micro-fabrication processes for 3D microstructures has led to the production of low-cost, low-energy devices at millimeter scales known as MEMS for a wide range of electronic, mechanical, mechatronic and biomedical applications. As surface-to-volume ratio increases drastically with decreasing dimension, surface properties of the materials are the prominent factor at the interface between two solids and consequent tribological issues such as adhesion, friction and wear will arise in MEMS devices when surfaces are in, or have the potential for, sliding contact. Measurement techniques and principles used in micro-tribology are quite different from those in macro-tribology. Various specialized micro-tribometers have attracted recent attention in attempts to obtain consistent, accurate tribological measurements that could provide information for the design of MEMS components. However, even these have operational parameters quite different to those in the regime typical of MEMS devices. For example, the thermal properties of polymers might mean that they are especially sensitivity to the speeds and reciprocating scan frequencies of measurements. This is a serious concern because the selection of appropriate materials for such applications is very important in order to reduce not only friction and wear, but also the stiction of the parts. The immediate challenge is that there is very little reliable information about the properties of this new generation of engineering materials because of insufficient understanding and characterization of their behaviour at the microscale under a wide range of experimental conditions. With these points in mind, this thesis aims to prompt wide study of the micro-tribological properties of polymers for MEMS applications, providing preliminary new data on them while exploring in some detail possible uncertainty effects that could arise from the testing regimes of most micro-tribometers. It starts by re-commissioning and characterizing a unique, wide-bandwidth prototype micro-tribometer developed at Warwick, establishing good operating procedures by comparing measurements on materials widely discussed in the literature. New data has been collected on an acrylate resin typically used for micro-stereo-lithography, PTFE and oxide-coated silicon. It suggests that deviations from Amonton’s law in the ten millinewton range might be less severe than previously reported. Observing that the skill and time required for such testing makes it unattractive for a production control environment, the thesis then explores, via contact modelling, whether there is a useful correlation between Berkovich tip nano-hardness and the micro-friction of the polymeric samples: several plausible modelling assumptions are shown to lead to inconsistencies. Final discussions and recommendations consider how to move on from these experimental scoping studies to acquire detailed evaluations of the properties of the best candidates under typical usage conditions prior to designers of potential products taking these materials and processes at all seriously.
5

Leutscher, de las Nieves Marcos. "Contributions to the linear programming approach for mean field games and its applications to electricity markets." Electronic Thesis or Diss., Institut polytechnique de Paris, 2022. http://www.theses.fr/2022IPPAG010.

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Cette thèse présente trois contributions principales liées à l'approche de programmation linéaire pour les jeux à champ moyen (MFGs).La première partie de la thèse traite les aspects théoriques des MFGs permettant simultanément arrêt optimal, contrôle stochastique et absorption. En utilisant la formulation de programmation linéaire pour ce type de MFGs, un résultat général d'existence pour les équilibres de Nash MFG est dérivé sous des hypothèses faibles à travers du théorème de point fixe de Kakutani-Fan-Glicksberg. Nous montrons que cette méthode de relaxation est équivalente à l'approche par martingales contrôlées/arrêtées pour les MFG, une autre méthode de relaxation utilisée dans des articles précédents dans le cas du contrôle. De plus, sous des conditions appropriées, nous montrons que notre notion de solution satisfait un système d'équations différentielles partielles (EDP), ce qui permet de comparer nos résultats avec la littérature sur les EDP.La deuxième partie se concentre sur un algorithme numérique pour l'approximation de l'équilibre de Nash MFG en tirant profit de l'approche par programmation linéaire. La convergence de cet algorithme est démontrée pour deux classes de MFG, les MFG avec arrêt optimal et absorption, et les MFG avec contrôle stochastique et absorption. Le schéma numérique appartient à la classe des procédures d'apprentissage. En particulier, nous appliquons l'algorithme Fictitious Play où la meilleure réponse à chaque itération est calculée en résolvant un problème de programmation linéaire.La dernière partie de la thèse porte sur une application des MFGs à la dynamique long terme de l'industrie de l'électricité. Différents scénarios macroéconomiques et de politique climatique sont possibles pour les années à venir, or le scénario exact reste incertain. Par conséquent, les producteurs conventionnels ou renouvelables visant à sortir du marché ou à y entrer, respectivement, sont confrontés à l'incertitude concernant le prix du carbone et les politiques climatiques à venir. Les deux classes de producteurs interagissent par le biais du prix de l'électricité. Des stratégies d'équilibre de Nash sur des temps d'arrêt sont considérées et le problème est analysé à travers d'un modèle MFG. À cette fin, nous développons l'approche de programmation linéaire pour les MFG d'arrêt optimal avec bruit commun et information partielle en temps discret. Nous montrons l'existence d'un équilibre de Nash MFG et l'unicité du prix de marché en équilibre. Enfin, nous étendons l'algorithme numérique développé dans la deuxième partie de la thèse pour illustrer le modèle avec un exemple empirique inspiré du marché de l'électricité britannique
This thesis presents three main contributions related to the linear programming approach for mean field games (MFGs).The first part of the thesis is concerned with the theoretical aspects of MFGs allowing simultaneously for optimal stopping, stochastic control and absorption. Using the linear programming formulation for this type of MFGs, a general existence result for MFG Nash equilibria is derived under mild assumptions by means of Kakutani-Fan-Glicksberg's fixed point theorem. This relaxation method is shown to be equivalent to the controlled/stopped martingale approach for MFGs, another relaxation method used in earlier papers in the pure control case. Furthermore, under appropriate conditions, we show that our notion of solution satisfies a partial differential equation (PDE) system, allowing to compare our results with the PDE literature.The second part focuses on a numerical algorithm for approximating the MFG Nash equilibrium taking advantage of the linear programming approach. The convergence of this algorithm is shown for two classes of MFG, MFGs with optimal stopping and absorption, and MFGs with stochastic control and absorption. The numerical scheme belongs to the class of learning procedures. In particular, we apply the Fictitious Play algorithm where the best response at each iteration is computed by solving a linear programming problem.The last part of the thesis deals with an application of MFGs to the long term dynamics of the electricity industry. Different macroeconomic and climate policy scenarios are possible for the coming years, and the exact scenario remains uncertain. Therefore, conventional or renewable producers aiming to exit or enter the market, respectively, are facing uncertainty about the future carbon price and climate policies. Both classes of producers interact through the electricity market price. Nash equilibrium strategies over stopping times are considered and the problem is analyzed through a MFG model. To this end, we develop the linear programming approach for MFGs of optimal stopping with common noise and partial information in discrete time. We show the existence of an MFG Nash equilibrium and the uniqueness of the equilibrium market price. Finally, we extend the numerical algorithm developed in the second part of the thesis to illustrate the model with an empirical example inspired by the UK electricity market
6

Bagnoli, Annalisa. "Estensioni trascendenti di campi." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9116/.

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Lo scopo di questa tesi è di studiare i principali risultati riguardanti le estensioni trascendenti di campi, l'indipendenza algebrica di elementi trascendenti su un campo, le basi di trascendenza di un'estensione. A partire da questi risultati vengono dimostrati due importanti teoremi di geometria algebrica: il Teorema degli zeri di Hilbert e il Teorema di Lüroth.
7

Nguyen, Duc. "Discrete and continuum modelling of micro-lattices in dynamics." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9116/.

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Materials with a sparse, periodic lattice microstructure exhibit excellent mechanical performance compared to their weight. Particularly, their engineered microstructure allows optimised mechanical behaviour under dynamic loading conditions. For instance, the material's microstructure can be manipulated such that wave filters emerge so that only certain frequencies can propagate through the material. Various techniques can be used to model such materials with lattice microstructures. For instance, a discrete model can be deployed whereby every strut of the lattice structure is modelled as a beam element. However, a more efficient approach is to replace such a detailed microscopic material model with an enriched continuum model for certain dynamic problems. Compared to the classical continuum, the new model allows the microstructural effects to be captured efficiently and effectively by equipping the continuum equations of elasticity with an appropriate set of higher-order spatial derivatives; hence, a gradient elasticity formulation is obtained. In order to link the additional constitutive coefficients of gradient elasticity to the geometric and mechanical properties of the lattice, in this thesis we use continualisation techniques whereby a representative volume element of a discrete square lattice model is translated into a homogeneous continuum formulation. Taylor series expansions and Pad\' approximations are usually required to ensure stability of the gradient elasticity model. The resulting continuum formulation is equipped with a range of strain gradient and inertia gradient terms. The dispersive properties of the model are then tested to check for the occurrence of wave filters. Applications of the Ru-Aifantis theorem are considered in detail. Finally, implementability with finite elements of the new continuum is examined. The research first reviews the one-dimensional case and subsequently applies the procedure to two-dimensional lattices of square, trapezium and hexagonal geometry arrangements.
8

Badin, Marcelo Gonsalez [UNESP]. "Um olhar sobre as contribuições do professor Nelson Onuchic para o desenvolvimento da matemática no Brasil." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/91016.

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O objetivo deste trabalho é apresentar as contribuições do professor Nelson Onuchic para o desenvolvimento da Matemática no Brasil, mostrando a atuação dele na criação dos cursos de Matemática da Unesp - Rio Claro e da USP - São Carlos, sua trajetória acadêmica, seus feitos como matemático e também como orientador, com significativa influência na implementação, em nosso país, de uma linha de pesquisa na área de equações diferenciais. Dessa forma, pretendemos contribuir para a escrita da história do desenvolvimento da Matemática no Brasil, relevando a participação do professor Onuchic no processo. Apresentamos, para isso, uma biografia de Nelson Onuchic, destacando o trabalho dele como professor e pesquisador, suas relações com as instituições de ensino e pesquisa onde atuou, sua produção acadêmica e a continuidade da linha de pesquisa por ele iniciada. Este estudo baseou-se em pesquisas documentais e entrevistas: as primeiras, realizadas nos arquivos pessoais de Lourdes Onuchic e nas universidades onde o professor Onuchic trabalhou; as entrevistas, realizadas com familiares dele, alunos e outros educadores com os quais ele conviveu durante a vida acadêmica. Entrevistas, realizadas com familiares dele, alunos e outros educadores com os quais ele conviveu durante a vida acadêmica.
This work aims at presenting Professor Nelson Onuchicþs contributions to the development of Mathematics in Brazil, showing his achievement in the creation of Mathematics courses at Unesp - Rio Claro and at USP - São Carlos, his academic trajectory and his performance as a mathematician and also as an advisor with significant influence in the implementation, in our country, of a line of research in the area of differential equations. In this way we intend to contribute to the writing of the history of the development of Mathematics in Brazil, pointing out Professor Onuchicþs participation in the process. To do so, we present Nelson Onuchicþs biography, focusing his work as a professor and researcher, his relations with the education and research institutions where he worked, his academic production and the continuity of the line of research that he initiated. This study was based on documentary research and on interviews: the first ones carried through in the personal archives of Lourdes Onuchic and at the universities where Professor Onuchic worked; the interviews were carried through with his family, his students and other educators with whom he lived during his academic life.
9

Benedetti, Francisco Carlos [UNESP]. "Funções, software gráfico e coletivos pensantes." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/91116.

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Esta pesquisa investiga as potencialidades de um software gráfico no coordenação das representações múltiplas de funções, por dois pares de estudantes de primeira série do Ensino Médio, os quais iniciavam o estudo desse assunto em suas aulas regulares. A relevância da investigação relaciona-se sobretudo à emergência de software gráficos gratuitos, bem como ao tema das representações múltiplas de funções, tanto em termos de currículo quanto ao cotodiano dos alunos. Sendo uma pesquisa qualitativa, a estratégia metodológica esperimentos de ensino foi utilizada ao se observarem ações desses estudantes no estudo das representações múltiplas de certas funções não tradicionalmente estudadas em sala de aula, na série considerada, como aquelas cujas expressões analíticas são...
10

Sampaio, Maria Nobre [UNESP]. "Desempenho ortográfico de escolares do ensino fundamental: elaboração e aplicação de um instrumento de intervenção." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91216.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
A aquisição da linguagem escrita permite aos escolares sua integração nas práticas sociais. No contexto educacional, a preocupação com o ensino e aprendizagem formal da escrita ganha destaque e preocupação por partes dos educadores e outros profissionais da área devido a sua complexidade no ensino e alto índice de escolares com dificuldades relacionadas à ortografia. Esta pesquisa apresentou-se na forma de três estudos. O Estudo 1 teve como objetivos levantar o perfil ortográfico dos escolares do 1º ao 5º ano do ensino público, visando caracterizar, comparar e classificar o desempenho ortográfico segundo a semiologia dos erros, bem como identificar o nível ortográfico desta população. Foram avaliados 150 escolares do 1º ao 5º ano escolar, de ambos os gêneros, na faixa etária de seis a 12 anos de idade. Como procedimento de avaliação foi aplicado o protocolo de avaliação ortográfica - Pro-Ortografia, na versão coletiva e individual. Como resultado foi possível verificar que os escolares avaliados apresentaram média de acertos que se tornaram superior com o aumento da seriação escolar no Pró-Ortografia e, com relação á classificação semiológica, os achados indicaram maior freqüência de erros de ortografia natural em relação aos erros de ortografia arbitrária. O Estudo 2 teve como objetivo a elaboração de um programa de intervenção com as dificuldades ortográficas segundo a semiologia dos erros. O Estudo 3 teve como objetivo verificar a eficácia do programa de intervenção em escolares com desempenho ortográfico inferior. Participaram deste estudo 40 escolares do 3º ao 5º ano do ensino fundamental público da cidade de Marília-SP, de ambos os gêneros, na faixa etária de oito a 12 anos de idade...
The acquisition of written language enables the students their integration into social practices. In the educational context, the concern with the learning and formal teaching of writing is emphasized and concern from the educators and other professionals because of its complexity in the education and indice high of students with difficulties related to spelling. This research was presented in the form of three studies. Study 1 aimed to raise the spelling profile of the students from 1st to 5th grades of public education, in order to characterize, to compare and to classify the spelling performance second the semiology of the errors as well as to identify the spelling standard of this population. 150 students from 1st to 5th grade school, of both genders, with aged of six to 12 years old were evaluated. As the evaluation procedure was applied the spelling evaluation protocol – Pro-Orthography, in collective and individual version. As result it was possible to verify that the students evaluated had an average of right answer that have become higher with increasing grade level school in the Pro-Orthography and with respect to semiologycal classification, the findings indicated a higher frequency of natural spelling errors in relation the arbitrary spelling errors. Study 2 aimed to elaborate of an intervention program with the spelling difficulties second the semiology of the errors. Study 3 aimed to verify the effectiveness of the intervention program in students with lower spelling performance. The study included 40 students of the 3rd to 5th grade of public elementary education of the city of Marília-SP, of both genders, in aged of eight to 12 years old, being distributed in the following groups: GI (20 students... (Complete abstract click electronic access below)
11

Franco, Camila Kauffmann Becaro [UNESP]. "Flutuação populacional de Meloidogyne mayaguensis em pomar de goiabeira e estudo do controle biológico com fungos nematófagos associado a culturas de cobertura." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/91316.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Para a cultura da goiabeira esse estudo é de grande interesse, visto que não existem nematicidas registrados. As práticas de manejo desse nematóide visam possibilitar a convivência com a doença. O objetivo da pesquisa foi avaliar a capacidade de parasitismo de ovos de Meloidogyne mayaguensis pelos fungos Pochonia clamydosporia Goddard, isolados FCAV-1 e FCAV-2, Paecilomyces lilacinus Thom., isolados FCAV-1, FCAV-2 e FCAV-3; avaliar a capacidade predatória de juvenis de segundo estádio desse nematóide pelos fungos Arthrobotrys musiformis Drechsler, Arthrobotrys sp., Dactylella leptospora Grove e Monacrosporium elegans Oudem, in vitro; avaliar a resistência de plantas de cobertura como milheto (Pennisetum glaucum), amendoim rasteiro (Arachis pintoi) e crotalária (Crotalaria spectabilis), em casa de vegetação; avaliar a eficácia de fungos nematófagos, adubo organomineral e as mencionadas culturas de cobertura, isoladas e em combinação no controle de M. mayaguensis, em pomar de goiabeiras e estudar a flutuação populacional desse nematoide no período de fevereiro a dezembro de 2009, em pomar de goiabeira irrigado e não irrigado. No presente estudo confirmou-se que a utilização combinada de culturas de cobertura resistentes a M. mayaguensis e fungos nematófagos reduziu significativamente a densidade de população de M. mayaguensis em pomar de goiabeira, e a curva de tendência da flutuação da população de M. mayaguensis em goiabeira, no Estado de São Paulo, exibe picos de população nos meses quentes e chuvosos do ano (fevereiro a dezembro)
This study is of great interest for the culture of guava, since there are no nematicides registered. Management practices are designed to allow these nematodes to living with the disease. The research aimed at evaluating the ability of egg parasitism of Meloidogyne mayaguensis fungi Pochonia clamydosporia Goddard, isolate FCAV-1 and FCAV-2, Paecilomyces lilacinus Thom., Isolate FCAV-1, FCAV-2 and FCAV- 3; evaluate the predatory ability of the fungi Arthrobotrys musiformis Drechsler, Arthrobotrys sp. Dactylella leptospora Grove and Monacrosporium elegans Oudem to second stage juveniles of this nematode, in vitro, evaluate the resistance of cover crops such as millet (Pennisetum glaucum), peanut crop (Arachis pintoi) and (Crotalaria spectabilis) under greenhouse conditions and to evaluate the efficacy of nematophagous fungi, organic mineral fertilizer and the aforementioned cover crops, alone and in combination to control M. mayaguensis, in an orchard of guava trees; and study population dynamics of nematodes in the period from February to December 2009 a the guava orchard with and without irrigation. In the present study it was confirmed that the combined use of cover crops resistant to M. mayaguensis and nematophagous fungi significantly reduced the population density of M. mayaguensis in guava trees, the trend line of population fluctuations of M. mayaguensis in guava in São Paulo, displays peak population in the hot and rainy months of the year (February- December)
12

Augusto, Neto Nelson [UNESP]. "Verificação dos níveis de atenuação de protetores auriculares do tipo concha, utilizando microfone sonda." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/91416.

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Dentre os agentes nocivos à saúde, confere-se ao ruído, um dos mais presentes nos ambientes urbanos e sociais, principalmente nos locais de trabalho e nas atividades de laser. Existem medidas eficazes para o controle do ruído e o Equipamento de Proteção Individual auricular (EPIa) é o mais utilizado na prevenção da Perda Auditiva Induzida por Ruído (PAIR), sendo que, uma vez instalada, a perda auditiva é irreversível. A perda auditiva vem sendo estudada com forte afinco desde o final do século XIX, desde então, diversas áreas do conhecimento têm realizado estudos com o objetivo de diminuir ou extinguir o problema. O objetivo principal desse estudo, foi o de verificar o real nível de atenuação de ruído de 3 (três) Equipamentos de Proteção Individual auditivo, do tipo concha da marca 3M, modelo 1445, AGENA, modelo ARS e MSA, modelo SORDIN CC. A verificação foi realizada comparando-se o nível de redução de ruído (NRR), nas freqüências de 250Hz, 500 Hz, 1KHz, 2KHz, 4KHz e 8KHz, apresentadas nos CA’s (Certificado de Aprovação) dos equipamentos da amostra, com os valores coletados nesta pesquisa. Foi apurado através da metodologia aplicada, que nenhum dos 3 (três) Equipamentos de Proteção Individual Auditivo apresentaram os valores de atenuação contidos no Certificado de Aprovação, nas freqüências estudas
Among the health harmful agents, it is conferred to the noise, one of the most presents in urban and social environments, mainly in workstations and the laser activities. There are efficient measures to control of the noise and the auricular Individual Protection Equipment is the most used to prevent of the Induced Auditory Loss by Noise, being that, once installed, the hearing loss is irreversible. The hearing loss has been studied with much dedication since the end of century XIX, since then, several areas of the knowledge have accomplished studies with the objective of decreasing or extinguishing problem. It has been observade the scarcity in the comfortable auditory products of individual and functionaries protection, related to durability, face to the efficient right of the equipment. The main objective of this studi, was to verify the real level of attenuation of noise of three Auditory Equipment Individual Protection, kind of shell of foam (3M), model 1445, AGENA model ARS and MSA, model SORDIN CC. The verification was realized companing the level of reduction of noise (NRR), on frequencies of 250Hz, 500Hz, 1KHz, 2KHz, 4KHz and 8KHz, presented in the CA's (approval certificate/licence) of equipment of specimen, with the valoures colecteds in this research. Was apurad through of metodology aplicade that none of 3 (three) Auditory Equipment Individual Protection presented the values of attenuation cantained in the approval Certificate/licence, in the frequencies studieds
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Neubern, Fabiula [UNESP]. "A arquitetura da criação: um estudo de Mínimos, múltiplos, comuns, de João Gilberto Noll." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/91516.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O presente trabalho de pesquisa tem como objetivo principal estudar os desdobramentos teóricos e críticos da singular composição de Mínimos, múltiplos, comuns (NOLL, 2003). O livro é constituído de 338 microcontos publicados originalmente no jornal Folha de S. Paulo. Para a publicação em livro, os textos foram agrupados em cinco conjuntos, divididos em subconjuntos pelo editor Wagner Carelli. Analisamos a situação da prosa brasileira contemporânea, do mercado editorial nacional e da produção de João Gilberto Noll e propomos formas de entender a estrutura do livro, considerando os aspectos editoriais e autorais. Faz-se também um breve histórico do conto e do microconto, dando ênfase à produção microcontística de Gilberto Noll. As reflexões deste trabalho se amplificam ao estudarmos a lógica organizacional cosmogônica da obra, tendo no mito da criação uma de suas linhas de força. Durante o trabalho, deparamo-nos com três microcontos que não foram inseridos em Mínimos, múltiplos, comuns (NOLL, 2003) e que são aqui analisados, permitindo reflexões a respeito da autoria
The present research aims to study the major theoretical developments and critical of the unique composition of Mínimos, múltiplos, comuns (NOLL, 2003). The book consists of 338 short stories originally published in the newspaper Folha de S. Paulo. For book publication, the texts were grouped into five sets, divided into subsets by the publisher Wagner Carelli. We analyzed the situation of contemporary Brazilian prose, the publishing industry and national production of João Gilberto Noll and propose ways to understand the structure of the book, taking into consideration editorial and copyright. It also makes a brief history of the tale and short story, emphasizing the production of Gilberto Noll. The reflections of this work is amplified when studying the organizational logic of cosmogonic work, and the myth of creation as one of its lines of force. During the work, we find three short stories that were not included in Mínimos, múltiplos, comuns (NOLL, 2003) and are reviewed here, allowing reflections on authorship
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Candido, Caroline Damico [UNESP]. "Avaliação de distribuição de doxorrubicina incorporada em microemulsão lipídica em tecido tumoral e cardíaco em Camundongos." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/91616.

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A doxorrubicina (DOX) é o antineoplásico mais utilizado na terapêutica no tratamento de tumores sólidos e leucemias, porém sua cardiotoxicidade limita, muitas vezes, a continuidade do tratamento. Neste contexto, Formariz (2008) desenvolveu uma microemulsão (ME) contendo DOX (DOX-ME) que apresentou cardiotoxicidade reduzida – avaliada através da atividade da enzima MB da creatinina quinase (CKMB) - em relação ao produto comercial (pó liofilizado na forma de cloridrato). A DOX incorporada nessa nova ME apresentou aumento da DL50 em ratos Wistar e camundongos com manutenção da DE50, com consequente aumento da sua margem de segurança. Em estudos de farmacocinética pré-clínica foi observado que a DOX incorporada a esta microemulsão lipídica teve seus parâmetros farmacocinéticos modificados, apresentando menor volume de distribuição e diminuição da cardiotoxicidade, fato que sugere menor captação do fármaco pelo miocárdio. Neste estudo investigou-se a distribuição da DOX em tecido cardíaco e tumoral em camundongos Swiss fêmeas, nas quais foi inoculado e desenvolvido o tumor de Ehrlich. Esses animais foram distribuidos em dois grupos (n=7 cada) que receberam, por via intraperitoneal e em dose única (10 mg/kg), a DOX veiculada por microemulsão (DOX-ME) ou na forma de cloridrato (DOX-Cl). Quinze minutos após a administração os animais foram sacrificados por deslocamento cervical e a massa tumoral total e o coração foram coletados. Após a coleta as amostras foram processadas e analisadas em um sistema UPLC Waters® com detecção por fluorescência (ƛ exc = 480 nm; ƛ em= 560 nm), utilizando coluna Acquity CSH C18 1,7 μm (2,1 x 100 mm), protegida por coluna de guarda Vanguard C18 1,7 μm (2,1 x 50 mm). A fase móvel foi constituída de acetonitrila : ácido fórmico 0,1% (40:60), em modo isocrático, em fluxo de 0,4 mL/min. O volume de injeção foi de 10 μL de amostra no sistema cromatográfico. O método...
Doxorubicin (DOX) is the most used antineoplastic in the therapy for the treatment of solid tumors and leukemias but its cardiotoxicity often limits the continuity of the treatment. In this context, Formariz (2008) developed a microemulsion (ME) containing DOX (DOX-ME) that showed reduced cardiotoxicity - assessed by the activity of the enzyme creatine kinase MB (CK-MB) - in relation to the commercial product (in the form of hydrochloride lyophilized powder). The DOX incorporated into the new ME showed an increase of LD50 in rats and mice with the maintaining of the ED50, consequently increasing its safety margin. In preclinical pharmacokinetic studies was observed that the DOX lipid microemulsion had its pharmacokinetic parameters modified, with smaller volume of distribution and reduced cardiotoxicity, which suggests less drug uptake by the myocardium. In this study was investigated the distribution of DOX in cardiac tissue and tumor in female Swiss mice, which were inoculated and developed Ehrlich tumor. These animals were divided in two groups (n = 7) that received intraperitoneal dose (10 mg / kg) of DOX microemulsion (ME DOX) or hydrochloride (DOX-Cl) . Fifteen minutes after the administration, the animals were sacrificed by cervical dislocation and the total tumor mass and heart were collected. After collecting, the samples were processed and analyzed on a Waters ® UPLC System with fluorescence detection (ƛ exc = 480 nm; ƛ em = 560 nm) using column Acquity CSH C18 1.7 micrometre (2.1 x 100 mm) protected by guard column C18 Vanguard 1.7 micrometre (2.1 x 50 mm). The mobile phase consisted of acetonitrile: 0.1% formic acid (40:60) in isocratic flow at 0.4 ml / min. The injection volume was 10 uL of sample into the chromatographic system. The bioanalytical method was validated in accordance with resolutions of ANVISA and the guidance of the FDA, and demonstrated confidence limits appropriate for their application in the ...
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Sato, André Issao [UNESP]. "Análise numérica de um coletor solar de tubo evacuado." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91716.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A utilização de coletores solares - seja para aquecimento de água, produção de energia elétrica, calefação de ambientes ou ainda alimentando sistemas de refrigeração - apresenta uma forte tendência de expansão. As principais razões para isto são que fontes de energias renováveis possuem baixo impacto ambiental além do fato que estes sistemas estão se tornando financeiramente acessíveis. A pesquisa científica neste campo tem acompanhado tal expansão e o coletor solar com tubos evacuados destaca-se como um importante foco de estudos. Projetos deste tipo caracterizam-se pelo seu peculiar processo de fabricação e a sua reduzida perda térmica para o ambiente, aumentando a sua eficiência, principalmente nas regiões frias. Quanto à análise dos fenômenos físicos presentes na operação deste equipamento, devem ser considerados os conceitos inerentes a todos os coletores, como: os mecanismos de captação de radiação solar, convecção natural, condução e os perfis de velocidades e temperaturas ao longo dos sistema. Com isto, diversos estudos foram publicados para obter a representação da estratificação do fluido no interior dos tubos e do reservatório, assim como para a modelagem analítica do problema de fluxo de calor. Este trabalho propõe o estudo de aquecedores solares com tubos evacuados, suas características de operação e parâmetros operacionais. Para o desenvolvimento desta pesquisa, utilizou-se uma ferramenta computacional auxiliar - neste caso, um software para fluidodinâmica computacional (na sigla em inglês, CFD)
The solar collectors usage - whether for water heating, electricity production, ambient heating or associated as heat source in cooling systems - has a strong expansion in studies and investments. The man reasons for this are that renewable energy sources have low environmental impact and the fact that these systems are becoming economic reliable. Researches in this field followed such expansion and the evacuated tube solar collector system stands as an important study focus. Such designs are characterized by their peculiar manufacturing process and its reduced heat loss to the ambient, which increases its thermal efficiency (especially in cold regions). The physical phenomena presented in the operation of this equipment is usually analyzed considering the concepts inherent to all collectos, such as concepts coupled to solar radiation receiving, natural convention heat transfer, conduction through glass thickness, and velocity and temperature profiles in the system. Numerous studies were published to represented the fluid stratification inside the tubes and the storage tank, as well as the analytical modeling of the fluid thermal problem. The objectives of this paper were the study of a solar heater with evacuated tube, regarding the operating characteristics and operational parameters. For this reason, a computational fluidynamics (CFD) was used
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Jacob, Rubens Ribeiro [UNESP]. "Manobra orbital terra-lua-terra." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/91816.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
No presente trabalho é abordada a manobra orbital Terra-Lua - Terra com o objetivo de um menor consumo de combustível. Inicialmente o satélite executa uma órbita em torno da Terra. Em um certo instante um impulso é efetuado para efetuar uma manobra não con-focal em que o satélite é transferido para uma órbita de transferência geocêntrica até um ponto da esfera de influência da Lua. A partir deste ponto o satélite é transferido para uma órbita hiperbólica em torno da Lua, e, no perilúnio desta órbita um novo impulso é dado transferindo o satélite para uma órbita lunar. A seguir é efetuada a manobra de volta em que o satélite é transferido para a órbitra geocêntrica de transferência, e no pericentro desta o satélite é transferido para a sua órbita inicial em torno da Terra. O caso não coplanar e a influência das perturbações devidas ao achatamento da Terra e a atração gravitacional da Lua também são analisados.
In the present work an Earth-Moon-Earth orbital maneuver is studied with the purpose of minimum fuel consumption. Initially it is considered an artificial satellite orbiting around the Earth. In a certain instant an impulse is effected to effect a not cofocal maneuver where the satellite is transferred to an orbit of geocentric transference until a point of the sphere of influence of the Moon. From this point the satellite is transferred to a hyperbolic orbit around the Moon, and, in the perilúnio of this orbit a new impulse is given transferring the satellite to a lunar orbit. To follow the maneuver is effected in return where the satellite is transferred to geocentric orbit of transference, and in pericentro of this the satellite is transferred to its initial orbit around the Earth. The non-coplanar case and the influence of the disturbances due to the flattening of the Earth and the gravitational attraction of the Moon also are analyzed.
17

Brasil, Pedro Ivo de Oliveira [UNESP]. "Satélites com alta excentricidade e/ou alta inclinação." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/91916.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Neste trabalho analisamos a evolução de alguns satélites de Júpiter sob a ação da migração planetária proposta por Tsiganis et al. (2005). Estudos de sobrevivência dos satélites além da órbita de Calisto são feitos. Tais estudos são realizados seguindo uma técnica recente apresentada em Deienno (2010). Nós também mostramos a plena possibilidade de captura de planetesimais que passam próximo do planeta. Tais objetos podem se tornar satélites irregulares de Júpiter. Realizamos uma análise destes planetesimais durante todo o tempo em que permaneceram capturados e comparamos com os atuais satélites irregulares. Finalmente, fizemos um estudo semianalítico, considerando uma análise qualitativa através de curvas de nível e superfícies de seçãso de Poincaré. Mostramos brevemente uma generalização da ressonância de Lidov-Kozai, onde aparecem dois novos centros
In this work we analyse the evolution of some Jupiter’s satellites submitted to planetary migration scenario proposed by Tsiganis et al. (2005). Studies on the survival of satellites beyond the orbit of Callisto are made. Such studies are done following a new and recent approach presented in Deienno (2010). We also show a clear possibility of capture of planetesimals that pass close the planet. Such objects can become Jupiters irregular satellites. We performed analysis of these captured planetesimals during entire period they were bound to Jupiter and compared with the existing irregular satellites. Finally, semi-analytical studies were done. Qualitative analysis through the level curves and Poincar´es surfaces of section of some orbits were considered. We briefly show a generalization of Lidov-Kozai resonance where two new centers of libration appear
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Townsend, Erik Matthew. "High-oxidation-state molybdenum and tungsten monoalkoxide pyrrolide alkylidenes as catalysts for olefin metathesis." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91116.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2014.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references.
Chapter 1 describes work toward solid-supported W olefin metathesis catalysts. Attempts to tether derivatives of the known Z-selective catalyst W(NAr)(C₃H₆)(pyr)(OHIPT) (Ar = 2,6- diisopropylphenyl, pyr = pyrrolide; HIPT = 2,6-bis-(2,4,6-triisopropylphenyl)phenyl) to a modified silica surface by covalent linkages are unsuccessful due to destructive interactions between W precursors and silica. W(NAr)(C₃H₆)(pyr)(OHIPT) and W(NAr)(CHCMe₂Ph)(pyr)(OHIPT-NMe₂) (HIPT-NMe 2 = 2,6-bis-(2,4,6-triisopropylphenyl)-4- dimethylaminophenyl) are adsorbed onto calcined alumina. W(NAr)(C 3H6 )(pyr)(OHIPT) is destroyed upon binding to alumina, while W(NAr)(CHCMe 2Ph)(pyr)(OHIPT-NMe 2) appears to bind through a non-destructive interaction between the dimethylamino group and an acidic surface site. The heterogeneous catalysts perform non-stereoselective metathesis of terminal olefins, and W(NAr)(CHCMe₂Ph)(pyr)(OHIPT-NMe₂) can be washed off the surface with polar solvent and perform solution-phase Z-selective metathesis. Chapter 2 details selective metathesis homocoupling of 1,3-dienes with Mo and W monoalkoxide pyrrolide (MAP) catalysts. A catalytically relevant vinylalkylidene complex, Mo(NAr)(CHCHCH(CH₃)₂)(Me₂pyr)(OHMT) (HMT = 2,6-bis(2,4,6-trimethylphenyl)phenyl; Me₂pyr = 2,5-dimethylpyrrolide), is isolated. A series of Mo and W MAP catalysts is synthesized and tested for activity, stereoselectivity, and chemoselectivity in 1,3-diene metathesis homocoupling. Catalysts containing the OHIPT ligand display excellent selectivity in general, and W catalysts are less active but more selective than their Mo counterparts. Chapter 3 recounts the synthesis and characterization of several heteroatom-substituted alkylidene complexes with the formula Mo(NAr)(CHER)(Me₂pyr)(OTPP) (TPP = 2,3,5,6- tetraphenylphenyl; ER = OPr, N-pyrrolidinonyl, N-carbazolyl, pinacolborato, trimethylsilyl, SPh, or PPh2). Synthesis proceeds via alkylidene exchange between Mo(NAr)(CHR)(Me₂pyr)(OTPP) (R = H, CMe₂Ph) and a CH₂CHER precursor. Each complex behaves similarly to known MAP complexes in olefin metathesis processes; the electronic identity of ER has little effect on catalytic properties. Distinctive features of alkylidene isomerism and catalyst resting state are examined. Chapter 4 contains synthetic and catalytic studies of thiolate-containing Mo and W imido alkylidene complexes. The species M(NAr)(CHCMe 2Ph)(pyr)(SHMT) (M = Mo or W), Mo(NAr)(CHCMe₂Ph)(Me₂pyr)(STPP), and Mo(NAr)(CHCMe₂Ph)(STPP)₂ are synthesized by substitution of the appropriate thiol or thiolate ligands for pyrrolide or triflate ligands in metal precursors. These complexes show similar structural and spectral characteristics to alkoxidecontaining species. The thiolate complexes and their alkoxide analogues are compared for activity and selectivity in metathesis homocoupling and ring-opening metathesis polymerization processes. In general, thiolate catalysts are slower and less selective than alkoxide catalysts.
by Erik Matthew Townsend.
Ph. D.
19

Taylor, Michael Eric 1970. "System identification and control of an Arleigh Burke Class Destroyer using an extended Kalman filter." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/91716.

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Thesis (Nav.E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.
Includes bibliographical references (leaves 88-92).
by Michael Eric Taylor.
Nav.E.
S.M.
20

Klier, Peter. "A visual language for parallel processing." Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/91316.

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21

Xia, Cassandra. "A game-based intervention for the reduction of statistical cognitive biases." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91416.

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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2014.
50
Title as it appears in MIT commencement exercises program, June 6, 2014: Probability playground: a set of games for statical intuition Cataloged from PDF version of thesis.
Includes bibliographical references (pages 48-50).
Probability and statistics is perhaps the area of mathematics education most directly applicable to everyday life. Yet, the methodologies traditionally used to cover these topics in school render the material formal and difficult to apply. In this thesis, I describe a game design that develops probabilistic concepts in real-life situations. Psychologists have coined the term cognitive bias for instances in which the intuition of the average person disagrees with the formal mathematical analysis of the problem. This thesis examines if a one-hour game-based intervention can enact a change in the intuitive mental models people have for reasoning about probability and uncertainty in real-life. Two cognitive biases were selected for treatment: overconfidence effect and base rate neglect. These two biases represent instances of miscalibrated subjective probabilities and Bayesian inference, respectively. Results of user tests suggest that it is possible to alter probabilistic intuitions, but that attention to the transitions from the current mental constructs must be carefully designed. Prototyping results suggest how some elements of game design may naturally lend themselves to deep learning objectives and heuristics.
by Cassandra Xia.
S.M.
22

Graves, Christopher Marten-Ellis. "Scratching with all your fingers : exploring multi-touch programming in Scratch." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91816.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 79-80).
Since the introduction of the iPhone in 2007, many millions of people have used a multi-touch interface; but, due to the inaccessibility of most tablet software development kits, very few of these people have ever developed their own multi-touch interactions. This thesis discusses the challenges in developing a toolkit that allows novices to easily make simple touch-interactive projects, while simultaneously empowering experienced users to create complex, personalized multi-touch interactions. Three potential toolkit designs are presented and evaluated using the principle of "low floors, wide walls, and high ceilings." The toolkits presented have been developed within the context of an upcoming tablet version of Scratch, which aims to allow users of all ages and educational backgrounds (but school-aged children in particular) to easily make and share their own stories, games, and animations on and for the tablet.
by Christopher Marten-Ellis Graves.
M. Eng.
23

Augusto, Neto Nelson. "Verificação dos níveis de atenuação de protetores auriculares do tipo concha, utilizando microfone sonda /." Bauru : [s.n.], 2007. http://hdl.handle.net/11449/91416.

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Orientador: João Cândido Fernandes
Banca: Andréa Cintra Lopes
Banca: Luiz Gonzaga Campos Porto
Resumo: Dentre os agentes nocivos à saúde, confere-se ao ruído, um dos mais presentes nos ambientes urbanos e sociais, principalmente nos locais de trabalho e nas atividades de laser. Existem medidas eficazes para o controle do ruído e o Equipamento de Proteção Individual auricular (EPIa) é o mais utilizado na prevenção da Perda Auditiva Induzida por Ruído (PAIR), sendo que, uma vez instalada, a perda auditiva é irreversível. A perda auditiva vem sendo estudada com forte afinco desde o final do século XIX, desde então, diversas áreas do conhecimento têm realizado estudos com o objetivo de diminuir ou extinguir o problema. O objetivo principal desse estudo, foi o de verificar o real nível de atenuação de ruído de 3 (três) Equipamentos de Proteção Individual auditivo, do tipo concha da marca 3M, modelo 1445, AGENA, modelo ARS e MSA, modelo SORDIN CC. A verificação foi realizada comparando-se o nível de redução de ruído (NRR), nas freqüências de 250Hz, 500 Hz, 1KHz, 2KHz, 4KHz e 8KHz, apresentadas nos CA's (Certificado de Aprovação) dos equipamentos da amostra, com os valores coletados nesta pesquisa. Foi apurado através da metodologia aplicada, que nenhum dos 3 (três) Equipamentos de Proteção Individual Auditivo apresentaram os valores de atenuação contidos no Certificado de Aprovação, nas freqüências estudas
Abstract: Among the health harmful agents, it is conferred to the noise, one of the most presents in urban and social environments, mainly in workstations and the laser activities. There are efficient measures to control of the noise and the auricular Individual Protection Equipment is the most used to prevent of the Induced Auditory Loss by Noise, being that, once installed, the hearing loss is irreversible. The hearing loss has been studied with much dedication since the end of century XIX, since then, several areas of the knowledge have accomplished studies with the objective of decreasing or extinguishing problem. It has been observade the scarcity in the comfortable auditory products of individual and functionaries protection, related to durability, face to the efficient right of the equipment. The main objective of this studi, was to verify the real level of attenuation of noise of three Auditory Equipment Individual Protection, kind of shell of foam (3M), model 1445, AGENA model ARS and MSA, model SORDIN CC. The verification was realized companing the level of reduction of noise (NRR), on frequencies of 250Hz, 500Hz, 1KHz, 2KHz, 4KHz and 8KHz, presented in the CA's (approval certificate/licence) of equipment of specimen, with the valoures colecteds in this research. Was apurad through of metodology aplicade that none of 3 (three) Auditory Equipment Individual Protection presented the values of attenuation cantained in the approval Certificate/licence, in the frequencies studieds
Mestre
24

Sato, André Issao. "Análise numérica de um coletor solar de tubo evacuado /." Bauru : [s.n.], 2012. http://hdl.handle.net/11449/91716.

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Abstract:
Orientador: Vicente Luiz Scalon
Banca: Carlos Alberto Carrasco Altemani
Banca: Alcides Padilha
Resumo: A utilização de coletores solares - seja para aquecimento de água, produção de energia elétrica, calefação de ambientes ou ainda alimentando sistemas de refrigeração - apresenta uma forte tendência de expansão. As principais razões para isto são que fontes de energias renováveis possuem baixo impacto ambiental além do fato que estes sistemas estão se tornando financeiramente acessíveis. A pesquisa científica neste campo tem acompanhado tal expansão e o coletor solar com tubos evacuados destaca-se como um importante foco de estudos. Projetos deste tipo caracterizam-se pelo seu peculiar processo de fabricação e a sua reduzida perda térmica para o ambiente, aumentando a sua eficiência, principalmente nas regiões frias. Quanto à análise dos fenômenos físicos presentes na operação deste equipamento, devem ser considerados os conceitos inerentes a todos os coletores, como: os mecanismos de captação de radiação solar, convecção natural, condução e os perfis de velocidades e temperaturas ao longo dos sistema. Com isto, diversos estudos foram publicados para obter a representação da estratificação do fluido no interior dos tubos e do reservatório, assim como para a modelagem analítica do problema de fluxo de calor. Este trabalho propõe o estudo de aquecedores solares com tubos evacuados, suas características de operação e parâmetros operacionais. Para o desenvolvimento desta pesquisa, utilizou-se uma ferramenta computacional auxiliar - neste caso, um software para fluidodinâmica computacional (na sigla em inglês, CFD)
Abstract: The solar collectors usage - whether for water heating, electricity production, ambient heating or associated as heat source in cooling systems - has a strong expansion in studies and investments. The man reasons for this are that renewable energy sources have low environmental impact and the fact that these systems are becoming economic reliable. Researches in this field followed such expansion and the evacuated tube solar collector system stands as an important study focus. Such designs are characterized by their peculiar manufacturing process and its reduced heat loss to the ambient, which increases its thermal efficiency (especially in cold regions). The physical phenomena presented in the operation of this equipment is usually analyzed considering the concepts inherent to all collectos, such as concepts coupled to solar radiation receiving, natural convention heat transfer, conduction through glass thickness, and velocity and temperature profiles in the system. Numerous studies were published to represented the fluid stratification inside the tubes and the storage tank, as well as the analytical modeling of the fluid thermal problem. The objectives of this paper were the study of a solar heater with evacuated tube, regarding the operating characteristics and operational parameters. For this reason, a computational fluidynamics (CFD) was used
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Brasil, Pedro Ivo de Oliveira. "Satélites com alta excentricidade e/ou alta inclinação /." Rio Claro : [s.n.], 2011. http://hdl.handle.net/11449/91916.

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Orientador: Tadashi Yokoyama
Banca: Rodney da Silva Gomes
Banca: Nelson Callegari Junior
Resumo: Neste trabalho analisamos a evolução de alguns satélites de Júpiter sob a ação da migração planetária proposta por Tsiganis et al. (2005). Estudos de sobrevivência dos satélites além da órbita de Calisto são feitos. Tais estudos são realizados seguindo uma técnica recente apresentada em Deienno (2010). Nós também mostramos a plena possibilidade de captura de planetesimais que passam próximo do planeta. Tais objetos podem se tornar satélites irregulares de Júpiter. Realizamos uma análise destes planetesimais durante todo o tempo em que permaneceram capturados e comparamos com os atuais satélites irregulares. Finalmente, fizemos um estudo semianalítico, considerando uma análise qualitativa através de curvas de nível e superfícies de seçãso de Poincaré. Mostramos brevemente uma generalização da ressonância de Lidov-Kozai, onde aparecem dois novos centros
Abstract: In this work we analyse the evolution of some Jupiter's satellites submitted to planetary migration scenario proposed by Tsiganis et al. (2005). Studies on the survival of satellites beyond the orbit of Callisto are made. Such studies are done following a new and recent approach presented in Deienno (2010). We also show a clear possibility of capture of planetesimals that pass close the planet. Such objects can become Jupiters irregular satellites. We performed analysis of these captured planetesimals during entire period they were bound to Jupiter and compared with the existing irregular satellites. Finally, semi-analytical studies were done. Qualitative analysis through the level curves and Poincar'es surfaces of section of some orbits were considered. We briefly show a generalization of Lidov-Kozai resonance where two new centers of libration appear
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Badin, Marcelo Gonsalez. "Um olhar sobre as contribuições do professor Nelson Onuchic para o desenvolvimento da matemática no Brasil /." Rio Claro : [s.n.], 2006. http://hdl.handle.net/11449/91016.

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Orientador: Sergio Roberto Nobre
Banca: Rosa Lúcia Sverzut Baroni
Banca: Renata Cristina Geromel Meneghetti
Resumo: O objetivo deste trabalho é apresentar as contribuições do professor Nelson Onuchic para o desenvolvimento da Matemática no Brasil, mostrando a atuação dele na criação dos cursos de Matemática da Unesp - Rio Claro e da USP - São Carlos, sua trajetória acadêmica, seus feitos como matemático e também como orientador, com significativa influência na implementação, em nosso país, de uma linha de pesquisa na área de equações diferenciais. Dessa forma, pretendemos contribuir para a escrita da história do desenvolvimento da Matemática no Brasil, relevando a participação do professor Onuchic no processo. Apresentamos, para isso, uma biografia de Nelson Onuchic, destacando o trabalho dele como professor e pesquisador, suas relações com as instituições de ensino e pesquisa onde atuou, sua produção acadêmica e a continuidade da linha de pesquisa por ele iniciada. Este estudo baseou-se em pesquisas documentais e entrevistas: as primeiras, realizadas nos arquivos pessoais de Lourdes Onuchic e nas universidades onde o professor Onuchic trabalhou; as entrevistas, realizadas com familiares dele, alunos e outros educadores com os quais ele conviveu durante a vida acadêmica. Entrevistas, realizadas com familiares dele, alunos e outros educadores com os quais ele conviveu durante a vida acadêmica.
Abstract: This work aims at presenting Professor Nelson Onuchicþs contributions to the development of Mathematics in Brazil, showing his achievement in the creation of Mathematics courses at Unesp - Rio Claro and at USP - São Carlos, his academic trajectory and his performance as a mathematician and also as an advisor with significant influence in the implementation, in our country, of a line of research in the area of differential equations. In this way we intend to contribute to the writing of the history of the development of Mathematics in Brazil, pointing out Professor Onuchicþs participation in the process. To do so, we present Nelson Onuchicþs biography, focusing his work as a professor and researcher, his relations with the education and research institutions where he worked, his academic production and the continuity of the line of research that he initiated. This study was based on documentary research and on interviews: the first ones carried through in the personal archives of Lourdes Onuchic and at the universities where Professor Onuchic worked; the interviews were carried through with his family, his students and other educators with whom he lived during his academic life.
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Franco, Camila Kauffmann Becaro. "Flutuação populacional de Meloidogyne mayaguensis em pomar de goiabeira e estudo do controle biológico com fungos nematófagos associado a culturas de cobertura /." Jaboticabal : [s.n.], 2010. http://hdl.handle.net/11449/91316.

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Resumo: Para a cultura da goiabeira esse estudo é de grande interesse, visto que não existem nematicidas registrados. As práticas de manejo desse nematóide visam possibilitar a convivência com a doença. O objetivo da pesquisa foi avaliar a capacidade de parasitismo de ovos de Meloidogyne mayaguensis pelos fungos Pochonia clamydosporia Goddard, isolados FCAV-1 e FCAV-2, Paecilomyces lilacinus Thom., isolados FCAV-1, FCAV-2 e FCAV-3; avaliar a capacidade predatória de juvenis de segundo estádio desse nematóide pelos fungos Arthrobotrys musiformis Drechsler, Arthrobotrys sp., Dactylella leptospora Grove e Monacrosporium elegans Oudem, in vitro; avaliar a resistência de plantas de cobertura como milheto (Pennisetum glaucum), amendoim rasteiro (Arachis pintoi) e crotalária (Crotalaria spectabilis), em casa de vegetação; avaliar a eficácia de fungos nematófagos, adubo organomineral e as mencionadas culturas de cobertura, isoladas e em combinação no controle de M. mayaguensis, em pomar de goiabeiras e estudar a flutuação populacional desse nematoide no período de fevereiro a dezembro de 2009, em pomar de goiabeira irrigado e não irrigado. No presente estudo confirmou-se que a utilização combinada de culturas de cobertura resistentes a M. mayaguensis e fungos nematófagos reduziu significativamente a densidade de população de M. mayaguensis em pomar de goiabeira, e a curva de tendência da flutuação da população de M. mayaguensis em goiabeira, no Estado de São Paulo, exibe picos de população nos meses quentes e chuvosos do ano (fevereiro a dezembro)
Abstract: This study is of great interest for the culture of guava, since there are no nematicides registered. Management practices are designed to allow these nematodes to living with the disease. The research aimed at evaluating the ability of egg parasitism of Meloidogyne mayaguensis fungi Pochonia clamydosporia Goddard, isolate FCAV-1 and FCAV-2, Paecilomyces lilacinus Thom., Isolate FCAV-1, FCAV-2 and FCAV- 3; evaluate the predatory ability of the fungi Arthrobotrys musiformis Drechsler, Arthrobotrys sp. Dactylella leptospora Grove and Monacrosporium elegans Oudem to second stage juveniles of this nematode, in vitro, evaluate the resistance of cover crops such as millet (Pennisetum glaucum), peanut crop (Arachis pintoi) and (Crotalaria spectabilis) under greenhouse conditions and to evaluate the efficacy of nematophagous fungi, organic mineral fertilizer and the aforementioned cover crops, alone and in combination to control M. mayaguensis, in an orchard of guava trees; and study population dynamics of nematodes in the period from February to December 2009 a the guava orchard with and without irrigation. In the present study it was confirmed that the combined use of cover crops resistant to M. mayaguensis and nematophagous fungi significantly reduced the population density of M. mayaguensis in guava trees, the trend line of population fluctuations of M. mayaguensis in guava in São Paulo, displays peak population in the hot and rainy months of the year (February- December)
Orientador: Jaime Maia dos Santos
Coorientador: Pedro Luiz Martins Soares
Banca: Julio Cesar Galli
Banca: Marineide Mendonça Aguillera
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Jacob, Rubens Ribeiro. "Manobra orbital terra-lua-terra /." Guaratinguetá : [s.n.], 2009. http://hdl.handle.net/11449/91816.

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Orientador: Rodolpho Vilhena de Moraes
Banca: Othon Cabo Winter
Banca: Claudia Celeste Celestino
Resumo: No presente trabalho é abordada a manobra orbital Terra-Lua - Terra com o objetivo de um menor consumo de combustível. Inicialmente o satélite executa uma órbita em torno da Terra. Em um certo instante um impulso é efetuado para efetuar uma manobra não con-focal em que o satélite é transferido para uma órbita de transferência geocêntrica até um ponto da esfera de influência da Lua. A partir deste ponto o satélite é transferido para uma órbita hiperbólica em torno da Lua, e, no perilúnio desta órbita um novo impulso é dado transferindo o satélite para uma órbita lunar. A seguir é efetuada a manobra de volta em que o satélite é transferido para a órbitra geocêntrica de transferência, e no pericentro desta o satélite é transferido para a sua órbita inicial em torno da Terra. O caso não coplanar e a influência das perturbações devidas ao achatamento da Terra e a atração gravitacional da Lua também são analisados.
Abstract: In the present work an Earth-Moon-Earth orbital maneuver is studied with the purpose of minimum fuel consumption. Initially it is considered an artificial satellite orbiting around the Earth. In a certain instant an impulse is effected to effect a not cofocal maneuver where the satellite is transferred to an orbit of geocentric transference until a point of the sphere of influence of the Moon. From this point the satellite is transferred to a hyperbolic orbit around the Moon, and, in the perilúnio of this orbit a new impulse is given transferring the satellite to a lunar orbit. To follow the maneuver is effected in return where the satellite is transferred to geocentric orbit of transference, and in pericentro of this the satellite is transferred to its initial orbit around the Earth. The non-coplanar case and the influence of the disturbances due to the flattening of the Earth and the gravitational attraction of the Moon also are analyzed.
Mestre
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Candido, Caroline Damico. "Avaliação de distribuição de doxorrubicina incorporada em microemulsão lipídica em tecido tumoral e cardíaco em Camundongos /." Araraquara, 2013. http://hdl.handle.net/11449/91616.

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Orientador: Rosângela Gonçalves Peccinini
Coorientador: Iracilda Zeppone Carlos
Banca: Anselmo Gomes de Oliveira
Banca: Thalita Pedroni Formariz Pilon
Resumo: A doxorrubicina (DOX) é o antineoplásico mais utilizado na terapêutica no tratamento de tumores sólidos e leucemias, porém sua cardiotoxicidade limita, muitas vezes, a continuidade do tratamento. Neste contexto, Formariz (2008) desenvolveu uma microemulsão (ME) contendo DOX (DOX-ME) que apresentou cardiotoxicidade reduzida - avaliada através da atividade da enzima MB da creatinina quinase (CKMB) - em relação ao produto comercial (pó liofilizado na forma de cloridrato). A DOX incorporada nessa nova ME apresentou aumento da DL50 em ratos Wistar e camundongos com manutenção da DE50, com consequente aumento da sua margem de segurança. Em estudos de farmacocinética pré-clínica foi observado que a DOX incorporada a esta microemulsão lipídica teve seus parâmetros farmacocinéticos modificados, apresentando menor volume de distribuição e diminuição da cardiotoxicidade, fato que sugere menor captação do fármaco pelo miocárdio. Neste estudo investigou-se a distribuição da DOX em tecido cardíaco e tumoral em camundongos Swiss fêmeas, nas quais foi inoculado e desenvolvido o tumor de Ehrlich. Esses animais foram distribuidos em dois grupos (n=7 cada) que receberam, por via intraperitoneal e em dose única (10 mg/kg), a DOX veiculada por microemulsão (DOX-ME) ou na forma de cloridrato (DOX-Cl). Quinze minutos após a administração os animais foram sacrificados por deslocamento cervical e a massa tumoral total e o coração foram coletados. Após a coleta as amostras foram processadas e analisadas em um sistema UPLC Waters® com detecção por fluorescência (ƛ exc = 480 nm; ƛ em= 560 nm), utilizando coluna Acquity CSH C18 1,7 μm (2,1 x 100 mm), protegida por coluna de guarda Vanguard C18 1,7 μm (2,1 x 50 mm). A fase móvel foi constituída de acetonitrila : ácido fórmico 0,1% (40:60), em modo isocrático, em fluxo de 0,4 mL/min. O volume de injeção foi de 10 μL de amostra no sistema cromatográfico. O método ...
Abstract: Doxorubicin (DOX) is the most used antineoplastic in the therapy for the treatment of solid tumors and leukemias but its cardiotoxicity often limits the continuity of the treatment. In this context, Formariz (2008) developed a microemulsion (ME) containing DOX (DOX-ME) that showed reduced cardiotoxicity - assessed by the activity of the enzyme creatine kinase MB (CK-MB) - in relation to the commercial product (in the form of hydrochloride lyophilized powder). The DOX incorporated into the new ME showed an increase of LD50 in rats and mice with the maintaining of the ED50, consequently increasing its safety margin. In preclinical pharmacokinetic studies was observed that the DOX lipid microemulsion had its pharmacokinetic parameters modified, with smaller volume of distribution and reduced cardiotoxicity, which suggests less drug uptake by the myocardium. In this study was investigated the distribution of DOX in cardiac tissue and tumor in female Swiss mice, which were inoculated and developed Ehrlich tumor. These animals were divided in two groups (n = 7) that received intraperitoneal dose (10 mg / kg) of DOX microemulsion (ME DOX) or hydrochloride (DOX-Cl) . Fifteen minutes after the administration, the animals were sacrificed by cervical dislocation and the total tumor mass and heart were collected. After collecting, the samples were processed and analyzed on a Waters ® UPLC System with fluorescence detection (ƛ exc = 480 nm; ƛ em = 560 nm) using column Acquity CSH C18 1.7 micrometre (2.1 x 100 mm) protected by guard column C18 Vanguard 1.7 micrometre (2.1 x 50 mm). The mobile phase consisted of acetonitrile: 0.1% formic acid (40:60) in isocratic flow at 0.4 ml / min. The injection volume was 10 uL of sample into the chromatographic system. The bioanalytical method was validated in accordance with resolutions of ANVISA and the guidance of the FDA, and demonstrated confidence limits appropriate for their application in the ...
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Benedetti, Francisco Carlos. "Funções, software gráfico e coletivos pensantes /." Rio Claro : [s.n.], 2003. http://hdl.handle.net/11449/91116.

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Orientador: Marcelo de Carvalho Borba
Banca: Miriam Godoy Penteado
Banca: Edna Maura Zuffi
Resumo: Esta pesquisa investiga as potencialidades de um software gráfico no coordenação das representações múltiplas de funções, por dois pares de estudantes de primeira série do Ensino Médio, os quais iniciavam o estudo desse assunto em suas aulas regulares. A relevância da investigação relaciona-se sobretudo à emergência de software gráficos gratuitos, bem como ao tema das representações múltiplas de funções, tanto em termos de currículo quanto ao cotodiano dos alunos. Sendo uma pesquisa qualitativa, a estratégia metodológica "esperimentos de ensino" foi utilizada ao se observarem ações desses estudantes no estudo das representações múltiplas de certas funções não tradicionalmente estudadas em sala de aula, na série considerada, como aquelas cujas expressões analíticas são...(Resumo completo, clicar acesso eletrônico abaixo)
Mestre
31

Neubern, Fabiula. "A arquitetura da criação : um estudo de Mínimos, múltiplos, comuns, de João Gilberto Noll /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/91516.

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Orientador: Luiz Gonzaga Marchezan
Banca: Arnaldo Cortina
Banca: Sérgio Vicente Motta
Resumo: O presente trabalho de pesquisa tem como objetivo principal estudar os desdobramentos teóricos e críticos da singular composição de Mínimos, múltiplos, comuns (NOLL, 2003). O livro é constituído de 338 microcontos publicados originalmente no jornal Folha de S. Paulo. Para a publicação em livro, os textos foram agrupados em cinco conjuntos, divididos em subconjuntos pelo editor Wagner Carelli. Analisamos a situação da prosa brasileira contemporânea, do mercado editorial nacional e da produção de João Gilberto Noll e propomos formas de entender a estrutura do livro, considerando os aspectos editoriais e autorais. Faz-se também um breve histórico do conto e do microconto, dando ênfase à produção microcontística de Gilberto Noll. As reflexões deste trabalho se amplificam ao estudarmos a lógica organizacional cosmogônica da obra, tendo no mito da criação uma de suas linhas de força. Durante o trabalho, deparamo-nos com três microcontos que não foram inseridos em Mínimos, múltiplos, comuns (NOLL, 2003) e que são aqui analisados, permitindo reflexões a respeito da autoria
Abstract: The present research aims to study the major theoretical developments and critical of the unique composition of Mínimos, múltiplos, comuns (NOLL, 2003). The book consists of 338 short stories originally published in the newspaper Folha de S. Paulo. For book publication, the texts were grouped into five sets, divided into subsets by the publisher Wagner Carelli. We analyzed the situation of contemporary Brazilian prose, the publishing industry and national production of João Gilberto Noll and propose ways to understand the structure of the book, taking into consideration editorial and copyright. It also makes a brief history of the tale and short story, emphasizing the production of Gilberto Noll. The reflections of this work is amplified when studying the organizational logic of cosmogonic work, and the myth of creation as one of its lines of force. During the work, we find three short stories that were not included in Mínimos, múltiplos, comuns (NOLL, 2003) and are reviewed here, allowing reflections on authorship
Mestre
32

Sampaio, Maria Nobre. "Desempenho ortográfico de escolares do ensino fundamental : elaboração e aplicação de um instrumento de intervenção /." Marília :, 2012. http://hdl.handle.net/11449/91216.

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Orientador: Simone Aparecida Capellini
Banca: Dionísia Aparecida Cusin Lamônica
Banca: Tânia Moron Saes Braga
Resumo: A aquisição da linguagem escrita permite aos escolares sua integração nas práticas sociais. No contexto educacional, a preocupação com o ensino e aprendizagem formal da escrita ganha destaque e preocupação por partes dos educadores e outros profissionais da área devido a sua complexidade no ensino e alto índice de escolares com dificuldades relacionadas à ortografia. Esta pesquisa apresentou-se na forma de três estudos. O Estudo 1 teve como objetivos levantar o perfil ortográfico dos escolares do 1º ao 5º ano do ensino público, visando caracterizar, comparar e classificar o desempenho ortográfico segundo a semiologia dos erros, bem como identificar o nível ortográfico desta população. Foram avaliados 150 escolares do 1º ao 5º ano escolar, de ambos os gêneros, na faixa etária de seis a 12 anos de idade. Como procedimento de avaliação foi aplicado o protocolo de avaliação ortográfica - Pro-Ortografia, na versão coletiva e individual. Como resultado foi possível verificar que os escolares avaliados apresentaram média de acertos que se tornaram superior com o aumento da seriação escolar no Pró-Ortografia e, com relação á classificação semiológica, os achados indicaram maior freqüência de erros de ortografia natural em relação aos erros de ortografia arbitrária. O Estudo 2 teve como objetivo a elaboração de um programa de intervenção com as dificuldades ortográficas segundo a semiologia dos erros. O Estudo 3 teve como objetivo verificar a eficácia do programa de intervenção em escolares com desempenho ortográfico inferior. Participaram deste estudo 40 escolares do 3º ao 5º ano do ensino fundamental público da cidade de Marília-SP, de ambos os gêneros, na faixa etária de oito a 12 anos de idade... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The acquisition of written language enables the students their integration into social practices. In the educational context, the concern with the learning and formal teaching of writing is emphasized and concern from the educators and other professionals because of its complexity in the education and indice high of students with difficulties related to spelling. This research was presented in the form of three studies. Study 1 aimed to raise the spelling profile of the students from 1st to 5th grades of public education, in order to characterize, to compare and to classify the spelling performance second the semiology of the errors as well as to identify the spelling standard of this population. 150 students from 1st to 5th grade school, of both genders, with aged of six to 12 years old were evaluated. As the evaluation procedure was applied the spelling evaluation protocol - Pro-Orthography, in collective and individual version. As result it was possible to verify that the students evaluated had an average of right answer that have become higher with increasing grade level school in the Pro-Orthography and with respect to semiologycal classification, the findings indicated a higher frequency of natural spelling errors in relation the arbitrary spelling errors. Study 2 aimed to elaborate of an intervention program with the spelling difficulties second the semiology of the errors. Study 3 aimed to verify the effectiveness of the intervention program in students with lower spelling performance. The study included 40 students of the 3rd to 5th grade of public elementary education of the city of Marília-SP, of both genders, in aged of eight to 12 years old, being distributed in the following groups: GI (20 students... (Complete abstract click electronic access below)
Mestre
33

Henry, Michael L. "Winter survival of bermudagrass (Cynodon sp.) as influenced by traffic, mineral nutrition, plastic covers, cultural treatments, overseeding and freezing in late-winter dormancy." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/91116.

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The most important problem in using bermudagrass (Cynodon sp.) for turf at the northern limit of its adaptation is winter survival. Bermudagrass used for athletic complexes is exposed to the additional problem of uncontrolled or excessive traffic. This research was conducted to determine the effects of: 1) traffic and mineral nutrition; 2) clear plastic covers and cultural treatments and; 3) overseeding and late winter freezing on bermudagrass winter survival. Four separate experiments were conducted on field cultured Midiron bermudagrass. Various regimes of traffic, N and K fertility, clear plastic covers, cultural treatments and growth regulators were utilized to determine their affect on bermudagrass winter survival. A laboratory freeze was used, in two experiments, on plant samples taken from the field. Following the freezing procedure, the samples were then grown in the greenhouse. From these experiments, it was found that traffic applied just as turf growth initiates in the spring was the most damaging. Potassium fertility had no effect on post dormancy growth. Nitrogen did improve post dormancy growth of bermudagrass exposed to a late winter laboratory freeze and when plastic covers were applied during winter dormancy. Plastic covers enhanced post dormancy growth and offset the detrimental effect of imposed traffic. 'Stayz Green' turf colorant did increase early post dormancy growth. While, the cultivation treatments using a vertical mower alone and with an aerifier reduced early green up. Flurprimidal reduced early post dormancy growth of bermudagrass; while, mefluidide had no detrimental effect. Both growth regulators reduced the growth of the overseeded ryegrass, and mefluidide enhanced the competitiveness of bermudagrass in the ryegrass canopy.
M.S.
34

Косимов, Б. И. "Разработка и исследование вентильного двигателя с когтеобразными полюсами привода пильгерстана для изготовления бесшовных труб : диссертация на соискание ученой степени кандидата технических наук : 05.09.01." Thesis, б. и, 2020. http://hdl.handle.net/10995/91816.

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Chim, Rita Joana de Almeida Bento. "Estratégias verdes e biométricas para o desenvolvimento de materiais compósitos sílica / biopolímeros / biomoléculas para aplicações biomédicas e de Engenharia de tecidos." Master's thesis, [do autor], 2010. http://hdl.handle.net/10316/91316.

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O desenvolvimento de scaffolds visa a criação de estruturas tridimensionais, tendo por base materiais sintéticos ou naturais . Um dos principais objectivos deste trabalho é usar estratégias “verdes” e biomiméticas na formação e processamento de scaffolds como sistemas de libertação controlada, para aplicação em regeneração de tecidos duros, especialmente o tecido ósseo. Este trabalho envolve primeiramente a produção de sílica utilizando catalisadores biomiméticos, como a L-glutationa reduzida (GSH), a DL-metionina (MET) e a cisteamina (CYS)), através do processo sol-gel, usando como solvente a água e como percursor o tetraetilortosilicato (TEOS). A utilização destes catalisadores permite produzir sílica desde condições ácidas (pH 2,46 – GSH) até condições básicas (pH 9,81 – CYS). Estas condições podem gerar sílica com diferentes propriedades físico-químicas para aplicação em diversas áreas. A etapa de secagem da sílica, a eliminação de catalisadores e a incorporação da dexametasona para posterior libertação controlada, foram as principais prioridades deste trabalho. Além disso, foram estudadas formulações de compósitos, com potencial biomédico, à base de sílica e diversos polímeros (sintéticos e naturais). Para encapsulação e posterior libertação da dexametasona, foram seleccionados compósitos preparados com proteína de soja, albumina e quitosano, assim como o extracto de pinheiro como uma fonte natural de proantocianidinas. Tanto a sílica quanto os compósitos, foram caracterizados por microscopia, espectroscopia, termogravimetria, porosimetria e densitometria. Este trabalho apresenta resultados promissores para o uso de sílica como scaffolds na aplicação em regeneração de tecidos duros. A libertação controlada da dexametasona atingiu valores de até 80 g/mg de sílica, que ao ser aplicado no processo de regeneração óssea, poderá favorecer/promover os mecanismos de osteocondução e osteoindução. O teste de hemocompatibilidade realizados para a sílica produzida, mostrando que os catalisadores residuais podem aumentar o índice de hemólise.
The development of scaffolds has as a primary goal the formation of three-dimensional structures, based on synthetic or natural materials. One of the main purposes of this work is to use green and biomimetic strategies to prepare and process scaffolds as drug delivery systems, to be applied to hard tissue regeneration, especially bone tissue.This work involves the production of silica using biomimetic catalysts, as L-glutathione reduced (GSH), DL-methionine (MET) and cysteamine (CYS) through the sol-gel process, using water as solvent and Tetraethyl Orthosilicate (TEOS) as precursor. The use of such catalysts allows the production of silica from acidic conditions (pH 2,46 - GSH) to alkaline conditions (pH 9,81 - CYS). These conditions may generate silica with different physic-chemical conditions that can find applications in several areas. Silica drying step, catalysts removal, as well as dexamethasone incorporation for further controlled release, was the main priorities of this work. The formulation of composites with biomedical potential, based on silica and different synthetic and natural polymers, was also studied. Composites prepared with soybean protein, albumin and chitosan, as well as pinus extract as a natural source of proanthocyanidin, were selected for studies of encapsulation and release of dexamethasone. Both silica and composites were characterized by microscopy, spectroscopy, thermogravimetry, porosimetry and densitometry. This work presents promising results for the use of silica as scaffolds to apply in hard tissue regeneration. The sustained release of dexamethasone presented values up to 80 g/mg of silica, which may support/promote the osteoconductive and osteoinduction mechanisms during the regeneration process. The hemocompatibility assays for the silica produced indicate that the presence of catalytic residues may increase the hemolytic index.
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Garay, Collcutt Evelina. "Women Writers on a Wartime Liminal Voyage: A Critical Study of the Changing face of Blitzed London through the Eyes of Five Novelists." Doctoral thesis, Universidad de Alicante, 2018. http://hdl.handle.net/10045/91716.

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Esta tesis tiene una doble funcionalidad. Por una parte desea rescatar la obra literaria de varias mujeres autoras de la época y por otra parte destacar la permeabilidad de los espacios privados y públicos así como otros espacios limítrofes durante la guerra. Se pretende demostrar que el estudio de estos espacios liminales dentro de una literatura olvidada nos aporta nuevos datos y un conocimiento más amplio sobre la situación de la mujer durante la guerra en la ciudad de Londres, así como el alcance de su emancipación durante la contienda.
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TUMMINELLI, Gianluca. "Sviluppo di un convertitore di energia solare (S.E.C. - Solar Energy Converter) per applicazioni di efficientamento energetico in agricoltura attraverso un utilizzo ambientalmente sostenibile di suolo agricolo." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91216.

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Castillo, i. Merino David. "Tecnologia, economia i universitat: anàlisi dels efectes de les tecnologies de la informació i la comunicació sobre l'eficiència econòmica de les universitats virtuals." Doctoral thesis, Universitat Oberta de Catalunya, 2005. http://hdl.handle.net/10803/9116.

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Aquest treball d'investigació estudia el procés de transformació de les universitats dels països de l'OCDE durant les dues darreres dècades, en concret els paràmetres de la seva evolució cap al concepte d'universitat xarxa i la seva interacció amb l'adopció i difusió de l'ús de les tecnologies de la informació i la comunicació (TIC) en l'activitat docent i en la gestió universitàries.
En aquest marc, es determinen els patrons d'inversió d'una mostra d'universitats virtuals, definides com a universitats que desenvolupen la seva activitat formativa mitjançant sistemes d'e-learning, i s'analitza la relació entre TIC i eficiència econòmica, arribant a demostrar la hipòtesi principal següent: l'efecte complementari de la inversió en TIC i la innovació metodològica i organitzativa són els factors determinants de l'eficiència tècnica i assignativa d'aquesta tipologia d'universitats; a més, aquests patrons d'inversió expliquen la necessitat d'adaptar els sistemes de costos tradicionalment implantats en el sector universitari a una nova estructura de costos.
El presente trabajo de investigación estudia el proceso de transformación de las universidades de los países de la OCDE durante las dos últimas décadas, en concreto los parámetros de su evolución hacia el concepto de universidad red y su interacción con la adopción y difusión del uso de las tecnologías de la información y la comunicación (TIC) en la actividad docente y en la gestión universitarias.

En este marco, se determinan los patrones de inversión de una muestra de universidades virtuales, definidas como universidades que desarrollan su actividad formativa mediante sistemas de e-learning, y se analiza la relación entre TIC y eficiencia económica, llegando a demostrar la hipótesis principal siguiente: el efecto complementario de la inversión en TIC y la innovación metodológica y organizativa son los factores determinantes de la eficiencia técnica y asignativa de esta tipología de universidades; además, estos patrones de inversión explican la necesidad de adaptar los sistemas de costes tradicionalmente implantados en el sector universitario a una nueva estructura de costes.
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山田, 弘明, and Hiroaki YAMADA. "「われ疑う、故にわれ在り」 - デカルト『省察』(一及び二)の解釈." 名古屋大学文学部, 1987. http://hdl.handle.net/2237/9116.

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Warnock, Jeanie E. "Kind tyranny: Brother-sister relationships in Renaissance drama." Thesis, University of Ottawa (Canada), 2000. http://hdl.handle.net/10393/9116.

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The study focuses on the social, literary, and psychological significance of the brother-sister relationship to a broad range of Renaissance tragedy and tragicomedy. After a brief historical analysis of siblings, the thesis considers the brother-sister relationship as an important means for dramatists to explore questions of identity, of gender conflict, and of differing understandings of family. It also examines the relationship as a developing literary tradition in the drama of the Stuart period, a tradition which culminates in the works of John Ford. The first half of the study surveys a large range of non-Shakespearean revenge tragedy and tragicomedy. In revenge tragedy, violent brother-sister strife serves as a symbol of the self in turmoil, as an image of a disordered family and society, and as a focal point for tension over the nature of women. Brothers also subvert traditional family roles in their relationships with their sisters. The avenging brother and sister, joined in shared loyalty to their house, mount a legitimate challenge to the authority of husband and king; pandar brothers become diabolical inversions of father and husband. Proceeding to tragicomedy, the thesis analyzes the brother as a figure of illegitimate authority and considers the privileged position gained by royal sisters, whose noble blood renders them the equal of their brothers. The latter half of the dissertation reinterprets the plays of John Webster and John Ford. In The Duchess of Malfi, the royal siblings' similarity, close blood tie, and high rank overturn gender difference and affirm the intimate connection between the sexes. The study considers the importance of blood family to the Duchess' self-conception and examines Ferdinand's attempts to create identity by usurping the place of his sister's husband. Ford's two plays 'Tis Pity She's A Whore and The Fancies Chaste and Noble stand as the culmination of dramatic treatments of idealized and antagonistic brother-sister relationships alike. Both works contrast the opposing nature of physical and familial love and elevate asexual love above sexual passion, presenting a sibling tie which undermines the bond between husband and wife.
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Alidadi, Mahmoud. "Duct optimization for a ducted vertical axis hydro current turbine." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/9116.

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Turbines developed for the power production from the energy of tidal and river currents are commonly referred to as hydro current turbines. This research focuses on duct optimization for a ducted vertical axis hydro current turbine. As a first step, a discrete vortex method, referred to as “DVM”, is developed for the performance analysis of unducted vertical axis turbines. It is shown that the loads for an unstalled blade of a vertical axis turbine may be adequately approximated by a quasi-steady component and a pitching component. A new approach is developed for the calculation of nascent vortex position relative to the blade. Besides, a new approach is developed to take into account the effects of connection point between a blade and its supporting arm. Subsequently, a new numerical model, referred to as “BEM-DVM”, is developed for the performance calculation of ducted vertical axis turbines by combining a boundary element method referred to as “BEM” with the DVM model. Comparison of the results for unducted and ducted turbines showed that ducting significantly improves the power coefficient of a vertical axis turbine. In addition, the results showed that ducting decreases the torque fluctuations significantly, especially at high tip speed ratios. Based on the method developed for ducted turbines, a new approach is developed to calculate the effects of towing tank wall on experimental results. The results showed that the power coefficient of a turbine increases when it operates in a tank. This is especially true for a ducted turbine which has a higher blockage ratio than the unducted turbine in the tank. The results also showed that the amount of increase in power coefficient grows when the tank width decreases. An optimization study is conducted to find the duct shape that maximizes the output power of a vertical axis turbine. The optimized ducts results showed a higher power coefficient for the turbine relative to the results of experimentally tested ducts. It is also shown that there is an upper limit to the amount of increase in power coefficient due to ducting.
42

Yu, Chin-Lien. "A novel electrolyte for the sodium/iron chloride battery." Thesis, Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/9116.

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Johnson, Philip. "Evaluating systems of systems against mission requirements." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/9116.

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This thesis investigates the nature of systems problems and the need for an open viewpoint to explain a system by viewing it as part of a larger whole and explaining its role in terms of that larger whole. The problem this research investigates is wicked and hence is unique in each instance. Therefore, an empirical proof would only hold for that particular instantiation of the problem, not the problem as a whole. After exposing some of the limitations of traditional systems engineering to this type of problem it is clear that a new approach is needed. The approach taken in the thesis is model driven and it is the architecture of this approach that is the stable artefact rather than the artefacts of a particular solution. The approach developed in this research has been demonstrated to be practicable. Specifically, this research has developed and demonstrated a novel approach for a decision support system that can be used to analyse a system of systems as part of a larger whole from both open and closed viewpoints in order to support the decision of which systems to use to conduct a particular military mission. Such planning decisions are wicked due to the uncertain and unique nature of military missions. Critical rationalism was used to validate the model driven approach and to falsify a parametric approach representative of traditional systems engineering through historical case studies. The main issue found with the parametric approach was the entanglement of functionality with the individual systems selected to implement the system of systems. The advantage of the model driven approach is that it separates functionality from implementation and uses model transformation for systems specification. Thus, although wicked problems do not have an exhaustively describable set of potential solutions this thesis has shown that they are not unapproachable.
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Reinoso, Luis Enrique. "User interface optimization through breadth of distribution analysis." Monterey, California. Naval Postgraduate School, 1997. http://hdl.handle.net/10945/9116.

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Approved for public release; distribution is unlimited
A Java tutorial was developed as a World Wide Web (WWW) site for use in capturing user behavior data. Breadth of distribution analysis was then applied to the data collected in order to characterize the usage of the user interface through the shape, connectedness, and order of traversal of each user in the sample. The results reveal distinct user groups with different levels of user knowledge and needs in relation to the web site content The resulting user interface analysis process produces a set of recommendations for optimizing the user interface, including adaptive interfaces for different user subgroups and optimization of sequential rather than topical presentations
45

Zarur, Jury Juan Andrey 1970. "Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/9116.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2000.
Includes bibliographical references.
Catalytic combustion of methane has been widely studied as an alternative to gasphase homogeneous combustion. It allows combustion to occur at high levels of excess air, leading to more complete reaction and reduced hydrocarbon emissions. It further enables combustion to proceed at lower temperatures, significantly reducing the NO" production. Noble metal systems, such as platinum and palladium, have been studied as combustion catalysts. However, noble metal clusters tend to sinter or vaporize at the high combustion temperatures. Recently, complex oxides have been examined for methane combustion due to their enhanced thermal resistance. Barium hexaaluminate (BHA) was chosen for this research, since its unique crystalline structur~ has the potential to suppress grain growth at high temperatures. A novel reverse microemulsion-mediated sol-gel processing technique was developed to synthesize non-agglomerated BHA nanoparticles with high surface areas and thermal stability. The reverse microemulsion also provided a unique medium to achieve highly dispersed active species on BHA nanoparticles to enhance the catalytic performance for methane combustion. Reverse microemulsions of water/i30-octane and water/cyclohexane were successfully stabilized with a non-ionic surfactant system consisting of polyethoxylated and linear alcohols. The water/iso-octane system was found to be ideal for the sol-gel mediated synthesis, since it required only a small amount of surfactants for stabilization. Quasi-elastic light scattering and small-angle neutron scattering showed that at low water contents, the reverse microemulsions consisted of slightly polydisperse discrete aqueous domains with a core-shell structure. Systems with higher water contents could be best described with a bicontinuous structure with intermixed water and oil domains. The water/iso-octane system was found to possess excellent stability under the conditions required for reverse microemulsion-mediated sol-gel processing of BHA materials. The composition of the reverse microemulsion governed the morphology of the aqueous domains, which in tum determined the shape and aggregation of the BHA particles derived. Non-agglomerated nanospheres were recovered from reverse microemulsions with water volume fractions of 0.05-0.15. At higher water contents, percolation between aqueous domains in the system became significant, yielding BHA particles with filament-like morphologies. The water:alkoxide ratio in the sol-gel process determined the relative rates of hydrolysis and polycondensation reactions. At a relatively high water:alkoxide ratio of ~100 times the stoichiometric value, the stability of the reverse microemulsion was preserved throughout the aging process. Well-defined, high surface area BHA nanoparticles were successfully recovered from the medium by freeze drying. Residual surfactants and volatiles were best removed by supercritical drying. The resulting materials were crystallized at a relatively low temperature of 1050°C due to their superb chemical homogeneity. Surface areas of >160 m2/g and ultrafine grain sizes of S30 nm were retained by these BHA nanoparticles after calcination at l 300°C. Active transition metal and rare earth oxides could be deposited with ultrahigh dispersion on BHA nanoparticles during their aging in the reverse microemulsion medium. BHA nanoparticles coated with Mn02 and Ce02 clusters showed light-off (defined as 10% conversion of an air stream containing 1 vol% CH4) at remarkably low temperatures of ~400°C, rivaling noble metal systems. These novel materials sustained their activity for extended periods at temperatures in excess of 1000°C, demonstrating a thermal stability superior to other existing combustion catalysts. The performance of BHA-based materials was evaluated in an atmospheric burner operated under realistic industrial conditions. Catalyst systems were washcoated onto monoliths of different compositions and microstructures. Nickel foams and fiber reinforced honeycombs demonstrated excellent thermal shock resistance; the latter were preferred for high-temperature operations since they would give rise to negligible pressure drops. In our catalytic combustor design, nanocrystalline PdO/Ce02-BHA was used as the low-temperature ignition catalyst to initiate the reaction by 250°C. A mid temperature catalyst, such as MnOi-BHA or Ce02-BHA nanocomposite, was utilized to promote reaction in the range of 600-1000°C. A flame-supporting catalyst, consisting of pure nanostructured BHA was employed to stabilize the flame at temperatures up to 1300°C. Using this multi-stage catalyst design, flames of ultra-lean methane:oxygen ratios (0.2S~0.5) were ignited and sustained for extended periods over multiple heating-cooling- restarting cycles. This system successfully eliminated NOx production with no unburned hydrocarbon emissions in an effective catalytic methane combustion process.
by Juan Andrey Zarur Jury.
Ph.D.
46

Vian, Claire. "Efeitos da libertação miofascial na cervicalgia: uma revisão da literatura." Bachelor's thesis, [s.n.], 2020. http://hdl.handle.net/10284/9116.

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Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Fisioterapia
Objetivo: Determinar os efeitos da libertação miofascial (LMF) no tratamento da cervicalgia. Metodologia: Pesquisa computorizada realizada nas bases de dados PubMed, Cochrane Library, PEDro, Lilacs, e SciELO, foi efetuada usando a combinação de palavras-chave: (Myofascial Release OR myofascial release therapy) AND (Neck pain OR Cervical pain), e (Myofacsial release/neck pain) de acordo com guias de PRISMA. Apenas estudos randomizados controlados foram incluídos no estudo. Os estudos foram analisados usando a Physiotherapy Evidence Database scoring scale (PEDro). Resultados: Nesta revisão foram incluídos 5 artigos que cumpriram os critérios de elegibilidade com um total de 270 participantes e com média aritmética de 7/10 na escala de PEDro. Verificou-se que a LMF promoveu, de forma significativa a diminuição de sequelas devido a dor na cervical e o aumento de amplitude de movimento cervical. Conclusão: Os estudos incluídos nesta revisão sugerem que a LMF parece melhorar a sintomatologia da cervicalgia, devendo ser considerada como opção terapêutica no tratamento desta condição clínica.
Objective: To determine the effects of myofascial release (MFR)in the treatment of neck pain. Methodology: Computerized research conducted in the databases PubMed, Cochrane Library, PEDro, Lilacs, and SciELO, was performed using the combination of keywords: (Myofascial Release OR myofascial release therapy) AND (Neck pain OR Cervical pain), and (Myofascial release / neck pain) according to PRISMA guides. Only randomized controlled trials were included in the study. The studies were analyzed using the Physiotherapy Evidence Database scoring scale (PEDro). Results: this review included 5 articles that met the eligibility criteria with a total of 270 participants and with an arithmetic mean of 7/10 on the PEDro scale. It was found that the MFR significantly promoted the reduction of sequelae due to pain in the neck and increased cervical range of motion. Conclusion: The studies included in this review suggest that MFR seems to improve the symptoms of neck pain, and should be considered as a therapeutic option in the treatment of this clinical condition.
N/A
47

Silva, Sara Mendonça de Sousa e. "Políticas e Territórios da Agricultura Biológica em Portugal." Master's thesis, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa, 2012. http://hdl.handle.net/10362/9116.

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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Gestão do Território - Área de Especialização em Território e Desenvolvimento
Incidindo sobre a temática da agricultura biológica, que se pretende valorizar numa óptica geográfica, o estudo desenvolveu-se, essencialmente, a três níveis: (i) conhecimento dos actores, intenções e compromissos nacionais da e para a agricultura biológica; (ii) entendimento da dimensão e da dinâmica de evolução do modo de produção biológico nacional, no país e na Europa; e (iii) identificação e caracterização de identidades territoriais de agricultura biológica no país. Para dar resposta a esses intentos houve que, previamente, delimitar, de uma forma crítica, a temática do ponto de vista teórico, começando por uma descrição das fases de evolução, desde a sua génese à respectiva consolidação; seguida de uma caracterização das dimensões inerentes ao conceito em causa, que espelham o acumular de preocupações que acompanham a evolução global da sociedade; a que, por sua vez, se segue a sistematização do quadro regulamentar e apoios comunitários relativos à agricultura biológica, que têm vindo a ser reforçados no âmbito das sucessivas reformas da Política Agrícola Comum. O panorama da agricultura biológica em Portugal é apresentado, na presente dissertação, sob duas perspectivas complementares entre si: uma de contextualização e a outra associada à prática deste modo de produção. A primeira perspectiva de análise procura interpretar as condições de partida e os factores de desenvolvimento da agricultura biológica no país; caracterizar os seus principais actores, agrupando-os mediante o seu posicionamento na fileira; e, por fim, mas mais importante, avaliar as políticas nacionais relativas à matéria em questão, com base tanto na sistematização dos apoios para aí canalizados e respectiva síntese de execução, como na identificação de possíveis intenções delineadas no quadro dos instrumentos de política nacionais. A segunda perspectiva de análise, associada à prática, propriamente dita, deste modo de produção, integra, num primeiro momento, uma análise da evolução e distribuição da agricultura biológica nacional, no país e na Europa e, num segundo momento, a interpretação dos resultados da aplicação de análise de clusters aos 278 municípios de Portugal Continental, com vista ao estabelecimento de uma tipologia de territórios da agricultura biológica. Conscientes do papel deste modo de produção na valorização dos espaços rurais portugueses e no combate ao despovoamento dos mesmos, a tipologia espacial produzida, ao identificar seis territórios contrastados em função das características e dinamismo da temática em causa, pretende contribuir para uma necessária abordagem estratégica da agricultura biológica, que se deseja mais territorializada e em articulação com outros recursos (p. ex. bens naturais e culturais) ou iniciativas regionais (p. ex. ecoturismo e valorização do artesanato).
48

Kozhedubova, Zhanna. "Corporate governance and performance measures : the Spanish case." Master's thesis, Instituto Superior de Economia e Gestão, 2013. http://hdl.handle.net/10400.5/9116.

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Mestrado em Finanças
Corporate Governance é um dos temas com maior interesse público pela importância demonstrada para a saúde económica das empresas e da sociedade em geral. A importância dele baseia-se principalmente pelo estabelecimento de regras que definem as relações entre os gestores, accionistas e membros de conselho de administração. Esta tese tem como objetivo investigar a relação entre desempenho da empresa e corporate governance das 62 empresas espanholas selecionadas da Bolsa de Madrid no intervalo de tempo entre 2005 e 2012. Neste estudo foram usados três tipos de variáveis de desempenho, Financeiro (Retorno de Capital), de Mercado (Retorno das Acções) e Operacional (Retorno dos Ativos). Para o efeito utilizou-se um modelo de regressão linear com dados em painel. No final deste estudo concluímos que variáveis de Corporate Governance tais como: concentração de accionista, número de membros no conselho de administração, número de membros independentes têm forte impacto sobre o desempenho da empresa.
Corporate governance has been one of the subjects with a strong public interest because of its apparent importance for the economic health of corporations and society in general. His importance sets especially on definition of the relationship be-tween management, board directors and shareholders. This study researches the relationships among firm performance and the corpo-rate governance measures for 62 Spanish firms between 2005 and 2012. We use three types of firm performance variables, the Financial (Return on Equity), the Market (Stock Return) and the Operating (Return on Assets). For this purpose we have used a linear regression model with panel data. This analysis led to the conclusion of those corporate governance variables like shareholder concentration, number of independent board members and number of board members have strong influence on the firm.
49

Rodríguez, Olaya Celia Herminia. "Emilio Gutiérrez de Quintanilla: Entre la tradición y la modernidad." Master's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/9116.

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El documento digital no refiere asesor
Publicación a texto completo no autorizada por el autor
Manifiesta que el objeto de estudio es tanto la obra como el autor; Emilio Gutiérrez de Quintanilla y su tránsito entre la tradición y la modernidad, su predilección por el arte desde la perspectiva teórica e histórica, la crítica y hasta la práctica. Produjo gran cantidad de artículos, conferencias, ensayos, crítica de arte, durante su vida: desde la década de 1880 y su primer aporte; la traducción del libro de J. Proudhon, El arte y su destino social, hasta sus libros de compilaciones de ensayos y conferencias correspondientes a la década de 1920. La investigación comprende el análisis general de los textos, artículos de diferentes publicaciones periódicas, ensayos, conferencias y reseñas con un motivo en común; el arte; gracias al método histórico crítico que hemos aplicado, se podrá relacionar dicha producción con el autor y su contexto y reconocer sus caracteres, bien modernos o bien tradicionales.
Tesis
50

Hughes, Alistair Paul. "The accuracy of linear flux models in predicting reaction rate profiles in a model biochemical reaction system." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/9116.

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Includes bibliographical references
Metabolic flux analysis is commonly used in the modelling of biochemical reactions. The use of MFA models has gained large amounts of interest due to the simplicity of the computational procedures required for the model, and the exclusion of difficult to measure intracellular reaction data. There are many examples of the use of MFA models in literature studies in a number of applications, ranging from the medical industry through to the development of novel biochemical processes. Little to no mention is provided in literature studies regarding the applicability of the MFA model to a specified set of reaction data. Furthermore, the techniques and routines used to compute the flux models are not well described in these studies. The objectives of this research were to determine the sensitivity of the MFA models to various operating and kinetic parameters and to highlight the considerations required when setting up the computational routine used to solve the flux balances. The study was conducted using a model pathway populated with a set of hypothetical elemental reactions and branch points. The model pathway was used in this study to negate the affects of complex regulatory biochemical architectures which are not well described in literature. The use of the model pathway ensured that the reaction system was thermodynamically feasible and there was consistency in the mass balances. The exclusion of the complex regulatory reactions did not affect the accuracy of the results generated in this study. A set of reaction mechanisms were used to describe each reaction step and were populated with parameters reference from literature. The cellular and reactor mass balances were generated using correlations presented in literature.

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