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Journal articles on the topic "914.25/4/003"
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Schleid, Thomas, and Falk Lissner. "Oxidsulfidchloride der Lanthanide vom Typ M4OS4Cl2 (M = La-Nd) / M4OS4Cl2-Type Oxysulfide Chlorides of the Lanthanides (M = La -Nd)." Zeitschrift für Naturforschung B 49, no. 3 (March 1, 1994): 340–46. http://dx.doi.org/10.1515/znb-1994-0309.
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Abstract Oxysulfide chlorides, M4OS4Cl2, of the lanthanides (M = La - Nd) are obtained upon the oxidation of the metals with sulfur in the presence of MOCl (or M2O3) and MCl3 in appropriate molar ratios. Additional NaCl or an excess of MCl3 serving as a flux provide even single crystalline material after reactions at 850 °C for seven days in sealed tantalum capsules. The crystal structure of M4OS4Cl2 (hexagonal, P63mc, no. 186, Z = 2; M = La: a = 933.19(3), c = 701.22(4) pm, c/a = 0.7514, R = RH = 0.020; M = Ce: a = 925.49(3), c = 694.13(3) pm, c/a = 0.7500; M = Pr: a = 919.72(4), c = 688.53(4) pm, c/a = 0.7486; M = Nd: a = 914.25(4), c = 683.12(4) pm, c/a = 0.7472, R = 0.022, Rw = 0.019) contains isolated O2--centered (M3+)4 tetrahedra which are surrounded by twelve S2- and six Cl-, capping vertices, edges, and faces of each tetrahedron and linking to other [OM4] units. Basically, the structure is identical to that of Ba4OCl6 if Ba2+ is substituted by M3+ and 2/3 of the CL- anions are replaced by S2- to secure charge neutrality in M4OS4Cl2. Different models for the Cl-/S2- replacement are presented on the basis of comparisons of the Madelung part of the lattice energy (MAPLE) with the MAPLE sum of the binaries (M2O3, M2S3, and MCl3).
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Kott, A., C. Spear, D. Miller, A. Butler, and O. Markovic. "P.4.e.003 Proven methodology for selecting raters." European Neuropsychopharmacology 18 (August 2008): S498. http://dx.doi.org/10.1016/s0924-977x(08)70747-8.
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Blakely, Martin L. "To the Editor (DOI: 10.1007/s00268-003-1024-4)." World Journal of Surgery 27, no. 12 (December 1, 2003): 1337. http://dx.doi.org/10.1007/s00268-003-1024-4.
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Biswal, Shibadas, Jorge Fernando Mendez Galvan, Mercedes Macias Parra, Juan-Francisco Galan-Herrera, Monica Belisa Carrascal Rodriguez, Esteban Patricio Rodriguez Bueno, Manja Brose, et al. "Immunogenicity and safety of a tetravalent dengue vaccine in dengue-naïve adolescents in Mexico City." Revista Panamericana de Salud Pública 45 (June 11, 2021): 1. http://dx.doi.org/10.26633/rpsp.2021.67.
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Objective. To describe the immunogenicity and safety of a tetravalent dengue vaccine (TAK-003) in healthy adolescents living in Mexico City, an area considered non-endemic for dengue (NCT03341637). Methods. Participants aged 12–17 years were randomized 3:1 to receive two doses (Month 0 and Month 3) of TAK-003 or placebo. Immunogenicity was assessed by microneutralization assay of dengue neutralizing antibodies at baseline, Months 4 and 9. Solicited and unsolicited adverse events (AEs) were recorded after each vaccination. Serious (SAEs) and medically-attended AEs (MAAEs) were recorded throughout the study. Results. 400 adolescents were enrolled, 391 (97.8%) completed the study. Thirty-six (9%) were baseline seropositive to ≥1 serotypes (reciprocal titer ≥10). Geometric mean titers (GMTs) in baseline seronegative TAK-003 recipients were 328, 1743, 120, and 143 at Month 4, and 135, 741, 46, and 38 at Month 9 against DENV-1, -2, -3, and -4, respectively. Placebo GMTs remained <10. Tetravalent seropositivity rates in vaccine recipients were 99.6% and 85.8% at Months 4 and 9, respectively. One MAAE in each group was considered treatment-related (TAK-003: injection-site erythema, and placebo: pharyngitis). Conclusion. TAK-003 was immunogenic against all four serotypes and was well tolerated in dengue-naïve adolescents living in Mexico City.
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Shin, Soon Cheon, Beniamin Filimon, Yuefeng Yang, Zebin Hu, Vijayakrishna K. Gadi, and Weidong Xu. "Abstract 5078: Immune response markers following combination treatment with oncolytic adenovirus AMUN-003 and immune checkpoint inhibitors in a murine model of triple negative breast cancer." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5078. http://dx.doi.org/10.1158/1538-7445.am2023-5078.
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Abstract Background: Accounting for about 10-15% of all breast cancer diagnoses, triple negative breast cancer (TNBC) has the highest mortality rate partly attributable to few effective treatment options. We evaluated a novel oncolytic adenovirus (rAd.sT.GM; named as AMUN-003 by AmunBio, Inc) encoding sTGFβRIIFc (a TGF-β protein decoy) and GM-CSF transgenes in combination with ICI treatments in the mouse TNBC 4T1 subcutaneous model. We previously reported that infection of target cancer cells with AMUN-003 and co-treatment with ICI led to potent inhibition of tumor progression and lung metastasis without off-target organ or systemic toxicity. Here, we provide details on the specific immune markers associated with responses. Methods: Immune competent BALB/C mice harboring 4T1 tumors were treated with combinations of anti-PD1 antibody, anti-CTLA antibody, AMUN-003 or sham injections. We measured inflammatory serum cytokines/chemokine levels by Meso Scale immunoassays and immune modulator gene expression in lung, spleen and tumor by qRT-PCR. Results: The “Triplet” combination of AMUN-003, anti-PD1 and anti-CTLA-4 antibodies was associated with decrease of poor prognosis biomarkers in serum: TGF-β1: Triplet p< 0.001, ICIs p<0.01, AMUN-003 p< 0.05; IL-27p28/IL-30: Triplet and ICIs p< 0.05; IL-1β: Triplet, AMUN-003, ICIs, and AMUN-003+anti-CTLA-4 p< 0.05; TNF-α: Triplet p< 0.01, ICIs p<0.05, and increase of immune stimulatory IFN-γ: Triplet p<0.01 (all compared to the buffer). In lung tissue, no significant changes in cytokine/chemokine expression were detected, however Granzyme B levels were significantly increased in Triplet: p< 0.05. In spleen, we detected increased cytokine expression (IL-2: Triplet, anti-CTLA-4, AMUN-003+anti-PD-1 p< 0.05; IL-4: Triplet p< 0.001, AMUN-003+anti-PD-1, AMUN-003+anti-CTLA-4: p< 0.01). In tumor, expression of TGF-β1 was significantly decreased by triplet and ICIs treatments (both p<0.05), but increases in IFN-γ, IL-4, CXCR4, and Perforin were observed in several treatment groups. Conclusions and Summary: Our data support the interpretation that the most potent intratumoral and systemic anti-tumor response took place with triplet therapy. Specifically, triplet therapy led to reduction of markers of systemic pathogenic inflammation but activation of anti-tumor cellular immunity (e.g., IFN-γ). In lung (site of 4T1 metastases), Granzyme B expression indicated activated NK cell and cytotoxic T cell infiltration was greatest in Triplet. Tumor expression data for IFN-γ, IL-4, CXCR4, and Perforin have limited interpretability because several animals had complete remissions at the primary tumor. Collectively, quantitative protein and expression immune response data presented here further support advancement of combination testing of AMUN-003 and ICIs in human clinical trials. Citation Format: Soon Cheon Shin, Beniamin Filimon, Yuefeng Yang, Zebin Hu, Vijayakrishna K Gadi, Weidong Xu. Immune response markers following combination treatment with oncolytic adenovirus AMUN-003 and immune checkpoint inhibitors in a murine model of triple negative breast cancer. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5078.
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Heretik, A., V. Novotny, A. Heretik, J. Pecenak, and A. Ritomsky. "P.4.f.003 EPIA -anxiety as a trait in Slovakia." European Neuropsychopharmacology 16 (January 2006): S475—S476. http://dx.doi.org/10.1016/s0924-977x(06)70631-9.
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Figlin, Robert A., Asim Amin, Arkadiusz Dudek, Theodore Logan, Raymond S. Lance, Jeffrey M. Holzbeierlein, Viraj A. Master, et al. "Phase II study combining personalized dendritic cell (DC)-based therapy, AGS-003, with sunitinib in metastatic renal cell carcinoma (mRCC)." Journal of Clinical Oncology 30, no. 5_suppl (February 10, 2012): 348. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.348.
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348 Background: AGS-003 is a personalized immunotherapy that employs autologous DCs co-electroporated with the subject’s amplified tumor mRNA and synthetic CD40L RNA. Based on previous results with single agent AGS‐003 and acceptance of TKIs as the standard of care for mRCC, AGS-003 was evaluated in combination with sunitinib as initial treatment for advanced RCC. Progression free survival (PFS) results for the combination have been previously presented and show improvement compared to historical data in unfavorable risk patients treated with sunitinib alone. Methods: AGS-003-006 is an open label phase II study that included subjects with newly diagnosed, metastatic clear cell RCC. Tumor was harvested by nephrectomy or metastasectomy for mRNA. Autologous monocytes were collected by leukapheresis for the production of DCs. Subjects subsequently received sunitinib (4wks on, 2wks off) combined with AGS-003 (every 3wks X 5 doses, then every 12wks) until progression. AGS-003 doses consisted of 1 X 107 cells administered by intradermal injection to a single lymph node basin. Response was evaluated per RECIST and subjects followed for PFS and OS. Immune responses were assessed at baseline and after five AGS-003 doses using multiparametric flow cytometry. Results: 25 subjects were enrolled; 21 received treatment. The median PFS from registration for subjects receiving at least one dose of AGS-003 was 11.9 months. For subjects with 1–2 MSKCC risk factors (intermediate risk), PFS = 14.9 months and for subjects with 3–4 MSKCC risk factors (poor risk), PFS = 6.0 months. Median OS from registration has not been reached. Median OS for poor risk subjects = 7.9 months. Median OS for intermediate risk subjects has yet to be reached, but will exceed 28.3+ months. Conclusions: AGS-003 is well tolerated with no immunotherapy-related SAEs or grade 3/4 AEs reported. Interim data indicate that AGS-003 in combination with sunitinib yields a median OS higher than that reported for sunitinib alone in unfavorable risk subjects. Updated OS and immune response correlates will be presented. These results support the ongoing, randomized phase III ADAPT study.
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Anisah, Anisah. "PENERAPAN METODE PEMBERIAN TUGAS UNTUK MENINGKATKAN KEMANDIRIAN ANAK USIA 5-6 TAHUN DI TK SATU ATAP SDN 003 SIHEPENG TAHUN AJARAN 2016/2017." Jurnal Guru Kita PGSD 2, no. 1 (August 11, 2018): 137. http://dx.doi.org/10.24114/jgk.v2i1.10465.
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Abstrak: Penerapan Metode Pemberian Tugas untuk MeningkatkanKemandirian Anak Usia 5-6 Tahun di TK Satu Atap SDN 003 Sihepeng TahunAjaran 2016/2017. Tujuan penelitian ini adalah untuk meningkatkan kemandirianpada anak usia 5-6 tahun melalui penggunaan metode pemberian tugas di TK SatuAtap SDN 003 SihepengTahun Ajaran 2016/2017. Jenis penelitian yang digunakanpenulis adalah jenis PTK (Penelitian Tindakan Kelas). Penelitian ini dilakukan diTK Satu Atap SDN 003 SihepengSihepeng, Kecamatan Siabu KabupatenMandailing Natal Tahun Ajaran 2016/2017 dan waktu penelitian selama 4 bulan (bulanMaret 2017 - Juni 2017. Subjek penelitian ini adalah anak usia 5-6 tahun TKSatu Atap SDN 003 Sihepeng berjumlah 22 orang pada tahun ajaran 2016/2017.Sedangkan objek penelitian adalah meningkatkan kemandirian anak usia 5-6 tahundi TK Satu Atap SDN 003 TA 2016/2017. Hasil penelitian yang diperoleh yaitumetode pemberian tugas dapat meningkatkan kemandirian anak usia 5-6 tahun di TKSatu Atap SDN 003 Sihepeng T.A 2016/2017.Kata Kunci : Metode Pemberian Tugas, Kemandirian Anak
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Barua, H., M. H. Rahman, M. M. Alam Patwary, M. Zahirul Alam, and S. Nahar. "Variations in Growth and Yield of Indigenous Hyacinth Bean (Lablab purpureus (L.) Sweet) Genotypes." Agriculturists 12, no. 2 (January 25, 2015): 01–05. http://dx.doi.org/10.3329/agric.v12i2.21724.
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Variations in growth and yield of three hyacinth bean genotypes collected from Sitakundu of Chittagong, were investigated at the Agricultural Research Station (ARS) of Bangladesh Agricultural Research Institute (BARI), Pahartali, Chittagong during November 2011 to March 2012, where BARI Seem-4 was used as standard control. The minimum number of days for pod formation (54 days) was recorded in BARI Seem-4, while the maximum was in DLP 002 (62 days). The highest number of pods (324) per plant was obtained from DLP 001 followed by DLP 003 (212.33) and the lowest (148.33) was obtained from BARI Seem-4. The maximum weight (12.61 g) of single pod was observed in DLP 003, which is close to that of DLP 002 (12.23 g). The minimum weight of single pod (7.08g) was however observed in DLP 001. Weight of 100-green seed (117.17 g) was maximum in DLP 002, while that of DLP 001 was the minimum (85.90 g).The maximum green seed (61.86 %) was found in DLP 003 and the minimum was in DLP 001 (47.89 %). DLP 003 produced the highest pod yield (26.77 t/ha) which was followed by DLP 001 (22.94 t/ha), while BARI Seem-4 produced the lowest (17.43 t/ha), which is close to that of DLP 002 (19.57 t/ha).The Agriculturists 2014; 12(2) 01-05
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Mustika, Dea, Amisha Dewinta Amama, Aisyah Fitriani, Amelin Fahesa, Alvitta Tiara, Siti Quratul Ain, Leny Julia Lingga, and Deswalila Amanda. "Sosialisasi Program Kegiatan Kampus Mengajar Angkatan 4 di SD 003 YKWI Pekanbaru." Joong-Ki : Jurnal Pengabdian Masyarakat 2, no. 2 (May 23, 2023): 428–33. http://dx.doi.org/10.56799/joongki.v2i2.1720.
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Kampus mengajar merupakan bagian dari program Merdeka Belajar Kampus Merdeka. Kegiatan sosialisasi didasari karena dibutuhkannya kesepakatan program kegiatan kampus mengajar untuk dapat dilaksanakan di sekolah sasaran. Sosialisasi dilakukan dengan metode diskusi dan presentasi dengan tiga tahapan yaitu persiapan, sosialisasi kegiatan dan rencana tindak lanjut. Hasil kegiatan sosialisasi mendapatkan temuan bahwa pihak sekolah menerima dengan terbuka kedatangan tim kampus mengajar serta menunjukkan sikap antusias terhadap rencana program yang mahasiswa sampaikan. Harapan yang disampaikan oleh pihak sekolah agar program kampus mengajar dapat menjadi program berkelanjutan demi membantu meningkatkan mutu dan kualitas pembelajaran di sekolah-sekolah sasaran.
Dissertations / Theses on the topic "914.25/4/003"
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Gouiaa-Mtibaa, Amal. "Développement de nouvelles politiques de maintenance intégrée à la qualité en tenant compte de diverses contraintes opérationnelles." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0287/document.
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Ces dernières décennies ont vu une évolution remarquable du contexte économique des entreprises. Ceci est dû certainement à la compétition fortement croissante à laquelle elles sont confrontées. Cette forte concurrence a entraîné les entreprises à investiguer des voies pour améliorer leurs performances économiques tout en répondant aux mieux aux exigences de leurs clients. La clé de la réussite de la majorité des entreprises réside dans la mise en place d’une méthode de gestion économique des différentes fonctions. Les industriels et les chercheurs ont prouvé l’existence d’une forte interaction entre trois fonctions fondamentales de l’entreprise ; la maintenance, la production et la qualité. Ils ont démontrés qu’une gestion indépendante de ces trois fonctions n’est plus efficiente. Suite à ce constat, nous nous sommes intéressés dans ce projet de recherche au développement de nouvelles stratégies de maintenance intégrée à la production et à la qualité. En tenant compte du prix de vente, des coûts de retouche, de la maintenance et ceux de la production, une analyse de l’interdépendance des trois fonctions a permis de réaliser notre objectif qui consiste à maximiser les profits des entreprises. Le but de cette thèse consiste, à proposer des nouvelles approches de maintenance intégrée à la qualité en tenant compte de la dégradation progressive du système de production, son impact sur la qualité des produits finis et l’impact économique des actions de retouche. Des modèles analytiques ont été développés afin d’illustrer les stratégies proposées. L’effet de la dégradation du système de production sur la perte de qualité du produit fini et son impact économique ont été mis en équation par le biais de modèles mathématiques. Dans ce contexte, différentes politiques de maintenance (parfaite, imparfaite, semi parfaite) ont été traitées. L’existence des solutions optimales liées aux variables de décision a été démontrée analytiquement. Enfin, des résolutions numériques, basées sur des cas industriels, ont été présentées afin de valider les résultats théoriques obtenus. La robustesse des modèles analytiques développés a été prouvée par des études de sensibilitéThe last few decades have been marked by a remarkable change in the economic environment of companies. It is due certainly to the increasing competition that they face. This strong competition has led companies to investigate new ways to improve their economic performance while meeting their customers' requirements. The key to the success of the majority of companies lies in the implementation of an economic management method of various functions. Industry and researchers have demonstrated a strong interaction between the three fundamental functions of the company; maintenance, production and quality. They have demonstrated that an independent management of these three functions is no more efficient. Following this observation, we were interested in this research project in the development of new maintenance strategies integrated production and quality. Taking into account sales prices, reworking costs, maintenance costs and production costs, an analysis of the interdependence of the three functions enabled us to achieve our goal of maximizing the profits of companies. The purpose of this thesis is to propose new approaches integrated quality and maintenance taking into account the progressive degradation of the production system, its impact on the quality of output products and the economic impact of reworking actions. Analytical models have been developed to illustrate the proposed strategies. The effect of the degradation of the production system on the degradation of quality of output products and its economic impact has been modeled using mathematical models. In this context, various maintenance policies (perfect, imperfect, semi-perfect) have been studied. The existence of optimal solutions related to the decision variables has been analytically demonstrated. Finally, numerical resolutions, based on industrial cases, have been presented in order to illustrate the theoretical results obtained. The robustness of the analytical models developed has been proved by sensitivity studies
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Gouiaa-Mtibaa, Amal. "Développement de nouvelles politiques de maintenance intégrée à la qualité en tenant compte de diverses contraintes opérationnelles." Electronic Thesis or Diss., Université de Lorraine, 2017. http://www.theses.fr/2017LORR0287.
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Ces dernières décennies ont vu une évolution remarquable du contexte économique des entreprises. Ceci est dû certainement à la compétition fortement croissante à laquelle elles sont confrontées. Cette forte concurrence a entraîné les entreprises à investiguer des voies pour améliorer leurs performances économiques tout en répondant aux mieux aux exigences de leurs clients. La clé de la réussite de la majorité des entreprises réside dans la mise en place d’une méthode de gestion économique des différentes fonctions. Les industriels et les chercheurs ont prouvé l’existence d’une forte interaction entre trois fonctions fondamentales de l’entreprise ; la maintenance, la production et la qualité. Ils ont démontrés qu’une gestion indépendante de ces trois fonctions n’est plus efficiente. Suite à ce constat, nous nous sommes intéressés dans ce projet de recherche au développement de nouvelles stratégies de maintenance intégrée à la production et à la qualité. En tenant compte du prix de vente, des coûts de retouche, de la maintenance et ceux de la production, une analyse de l’interdépendance des trois fonctions a permis de réaliser notre objectif qui consiste à maximiser les profits des entreprises. Le but de cette thèse consiste, à proposer des nouvelles approches de maintenance intégrée à la qualité en tenant compte de la dégradation progressive du système de production, son impact sur la qualité des produits finis et l’impact économique des actions de retouche. Des modèles analytiques ont été développés afin d’illustrer les stratégies proposées. L’effet de la dégradation du système de production sur la perte de qualité du produit fini et son impact économique ont été mis en équation par le biais de modèles mathématiques. Dans ce contexte, différentes politiques de maintenance (parfaite, imparfaite, semi parfaite) ont été traitées. L’existence des solutions optimales liées aux variables de décision a été démontrée analytiquement. Enfin, des résolutions numériques, basées sur des cas industriels, ont été présentées afin de valider les résultats théoriques obtenus. La robustesse des modèles analytiques développés a été prouvée par des études de sensibilitéThe last few decades have been marked by a remarkable change in the economic environment of companies. It is due certainly to the increasing competition that they face. This strong competition has led companies to investigate new ways to improve their economic performance while meeting their customers' requirements. The key to the success of the majority of companies lies in the implementation of an economic management method of various functions. Industry and researchers have demonstrated a strong interaction between the three fundamental functions of the company; maintenance, production and quality. They have demonstrated that an independent management of these three functions is no more efficient. Following this observation, we were interested in this research project in the development of new maintenance strategies integrated production and quality. Taking into account sales prices, reworking costs, maintenance costs and production costs, an analysis of the interdependence of the three functions enabled us to achieve our goal of maximizing the profits of companies. The purpose of this thesis is to propose new approaches integrated quality and maintenance taking into account the progressive degradation of the production system, its impact on the quality of output products and the economic impact of reworking actions. Analytical models have been developed to illustrate the proposed strategies. The effect of the degradation of the production system on the degradation of quality of output products and its economic impact has been modeled using mathematical models. In this context, various maintenance policies (perfect, imperfect, semi-perfect) have been studied. The existence of optimal solutions related to the decision variables has been analytically demonstrated. Finally, numerical resolutions, based on industrial cases, have been presented in order to illustrate the theoretical results obtained. The robustness of the analytical models developed has been proved by sensitivity studies
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Espinoza, Pérez Andrea Teresa. "Optimisation de la conception de la chaîne d’approvisionnement pour une bioraffinerie durable." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0222/document.
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La croissance de la population mondiale et son effet sur la sécurité alimentaire et l'urgence du changement climatique, sont des facteurs qui favorisent des diverses innovations pour accroître l'efficacité de l'utilisation des ressources naturelles. Parmi lesquelles la biomasse est une ressource renouvelable d’une grande disponibilité. Une bioraffinerie peut transformer la biomasse en énergie durable, matériaux et des produits chimiques. Par contre, au début d'un projet de bioraffinerie, des décisions stratégiques doivent être prises. Et ainsi, le processus de décision doit tenir en compte diverses aspects, comme des conditions spécifiques du territoire où le projet est destiné à être déployé. Une étude récente montre que, bien que ce problème ait été traité par la communauté scientifique, l'accent est mis sur les facteurs de rentabilité économique. Cependant, considérer toutes les dimensions de la durabilité, «Économique», «Social», «Environnemental», «Technologique» et «Politique» est essentielle dans ce type de projets. Dans ces conditions, tous les outils d'optimisation disponibles ne conviennent pas. Par conséquent, une étude préliminaire sur les outils d'optimisation multi-objectifs est réalisée. Par la suite, une stratégie d'optimisation intégrant les dimensions de durabilité dans la phase amont du projet a été développée. En fin, le modèle développé a été appliqué à l'étude du déploiement de bioraffineries en Colombie. Ce modèle et son optimisation permettent une meilleure visibilité pour les décideurs, grâce à sa capacité de proposer des scénarios et d’évaluer les compromis de la durabilité en intégrant les préférences des parties prenantesThe growing global population and its effect on food security and the urgency for climate change mitigation, are issues that foster innovations to increase the efficiency of the use of natural resources. Among them, biomass is a renewable resource highly available. A biorefinery can transform biomass in source of energy, materials and chemical products. However, at the early stage of a biorefinery project, strategic decisions have to be made, including location, production capacity or technology to be used, determining the project’s feasibility. As a consequence, the decision process needs to consider several aspects, as the specific conditions of the territory where the project is supposed to be deployed. A recent study shows that despite this problem has been treated by the multiple objective programming community, the main focus has been centered on factors of economic profitability. However, consider the whole dimensions of sustainability, “Economical”, “Social”, “Environmental”, “Technological” and “Political” is essential in this kind of project. Under these conditions, not all available optimization tools are suitable. Hence, a preliminary study about multi-objective optimization tools is realized. Then, a general optimization modeling strategy integrating the sustainability dimensions at the early stage of a biorefinery project is developed. To finish, the developed model is applied to the case study of biorefinery deployment in Colombia. It will permit a better visibility for decision makers, because its capability to propose scenarios and evaluate sustainability trade-offs by integrating stakeholders preferences
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Dakil, Manal. "Développement d'une méthodologie conjointe d'analyse structurelle et de sûreté de fonctionnement des propriétés d'un système complexe." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0133/document.
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Ce sujet de thèse concerne le développement d’analyse des propriétés structurelles en interaction avec des indicateurs de fiabilité. Notre étude porte sur des systèmes structurés (linéaire, bilinéaire ou linéaire à commutations), ces derniers doivent vérifier quelques propriétés importantes pour l’accomplissement de leur mission. Ces propriétés dépendent de la structure du système, d’où l’appellation "propriétés structurelles". La structure du système peut être représentée par un graphe composé de sommets et d’arcs. La vérification des propriétés structurelles dépend principalement de 4 conditions élémentaires de connectivité, de lien, de distance et de couplage complet. Nous avons développé des algorithmes permettant de les exprimer sous forme d’expressions booléennes basées sur les arcs du graphe représentant le système. Nous considérons que chaque arc est lié aux composants du système. Une défaillance au niveau des composants peut provoquer la modification de la structure du système, et donc peut rendre une propriété structurelle insatisfaite. Ainsi, les propriétés structurelles sont écrites sous forme d’expressions booléennes basées sur l’état de fonctionnement des composants. En utilisant les expressions booléennes associées aux propriétés structurelles, leur fiabilité et/ou disponibilité peut être calculée sachant les caractéristiques de sûreté de fonctionnement des composants du système. À travers cette étude, nous pouvons vérifier si, pendant le temps de mission du système, une propriété structurelle restera satisfaite et/ou respectera un niveau de performance exigé par un cahier des chargesThis thesis concerns the development of analysis of structural properties in interaction with indicators of reliability. Our study focuses on (linear, bilinear or switching) structured systems, they must verify some important properties for the accomplishment of their mission. Properties depend on the structure of the system, hence the term "structural properties". The structure of the system can be represented by a graph consisting of vertices and edges. Verification of structural properties depends mainly on four basic conditions of connectivity, link distance and complete linkage. We have developed algorithms to express the form of Boolean expressions based on the edges of the graph representing the system. We consider that each edge is linked to the system components. A failure at the component level can cause changes in the structure of the system, and therefore can make a structural property unsatisfied. Thus, the structural properties are written as boolean expressions based on the operating state of the components. Using boolean expressions associated to the structural properties, reliability and / or availability can be calculated knowing the characteristics of the system components. Through this study, we can check if during the mission time of the system, a structural property remain satisfied and / or comply with a level of performance required by the specifications
5
Sassi, Ons. "Planification de la recharge et optimisation des tournées dans le cas de flottes captives." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0303.
Full textAbstract:
Le véhicule électrique est actuellement au coeur des alternatives énergétiques qui permettent de faire face à la croissance du coût du carburant et au réchauffement climatique. En revanche, l’autonomie limitée des batteries des véhicules électriques et l’indisponibilité d’un nombre suffisant de bornes de recharge représentent des enjeux majeurs auxquels se trouvent confrontés les utilisateurs. Le déploiement des véhicules électriques doit alors passer par la conception et l’expérimentation des outils d’aide à la décision pour gestion optimisée et adaptée de l’écosystème du véhicule électrique. C’est dans ce contexte que s’inscrit cette thèse qui vise à fournir des outils d’aide à la décision pour l’optimisation des usages, de la recharge et des tournées des véhicules électriques dans le cadre industriel. Dans un premier temps, nous proposons d’étudier le problème d’optimisation conjointe de l’affectation et de la recharge des véhicules électriques. L’objectif de ce problème est de maximiser l’usage des véhicules électriques et minimiser les coûts de recharge tout en prenant en compte les contraintes d’ordre opérationnel et technique. Pour résoudre ce problème, nous proposons une méthode exacte et deux heuristiques. Nous comparons les performances de ces méthodes sur des instances réelles et d’autres aléatoires. Nous exposons ensuite plusieurs extensions au problème de base en intégrant de nouvelles fonctions objectif et de nouvelles contraintes. Nous étudions par la suite notre problème de point de vue ordonnancement et nous proposons une étude de complexité et des algorithmes d’approximation avec garantie de performance pour le problème d’ordonnancement d’intervalles sous contraintes d’énergie. Finalement, nous nous intéressons à un nouveau problème de construction de tournées pour une flotte mixte de véhicules électriques et thermiques. Pour résoudre ce problème, nous proposons des heuristiques et des méta-heuristiques hybrides et nous comparons les performances des différentes méthodes sur des instances généralisées de la littératureElectric Vehicles may decrease transportation-related emissions and provide for less dependence on foreign oil. However, electric vehicles are still facing many weaknesses related to the high purchase prices, limited battery range and scarce charging infrastructure. The deployment of electric vehicles must then involve the design and the deployment of charging infrastructures. Within this study, the overall objective is to provide enhanced optimization methods and decision tools for electric vehicles assignment, charging and routing that are relevant to different real-world constraints. Firstly, we propose to study the joint scheduling and optimal charging of electric vehicles problem. This problem consists in assigning a set of already constructed routes to the available electric and conventional vehicles and in, simultaneously, optimizing the electric vehicles charging costs while ensuring that all constraints are satisfied. The objective of this problem is to maximize the use of EVs and to minimize charging costs. Secondly, we propose different extensions to our baseline problem and we vary the objective functions and the considered constraints. Moreover, our problem can be seen as a fixed interval scheduling problem with complementary constraints of energy. We propose then to study the complexity and the approximability of many variants of this new problem. Finally, we consider a new variant of the electric vehicle routing problem with a heterogeneous fleet of vehicles and we propose different heuristics and metaheuristics to solve it. We test the different solving methods on benchmark instances and we evaluate the efficiency of each method
6
Dakil, Manal. "Développement d'une méthodologie conjointe d'analyse structurelle et de sûreté de fonctionnement des propriétés d'un système complexe." Electronic Thesis or Diss., Université de Lorraine, 2014. http://www.theses.fr/2014LORR0133.
Full textAbstract:
Ce sujet de thèse concerne le développement d’analyse des propriétés structurelles en interaction avec des indicateurs de fiabilité. Notre étude porte sur des systèmes structurés (linéaire, bilinéaire ou linéaire à commutations), ces derniers doivent vérifier quelques propriétés importantes pour l’accomplissement de leur mission. Ces propriétés dépendent de la structure du système, d’où l’appellation "propriétés structurelles". La structure du système peut être représentée par un graphe composé de sommets et d’arcs. La vérification des propriétés structurelles dépend principalement de 4 conditions élémentaires de connectivité, de lien, de distance et de couplage complet. Nous avons développé des algorithmes permettant de les exprimer sous forme d’expressions booléennes basées sur les arcs du graphe représentant le système. Nous considérons que chaque arc est lié aux composants du système. Une défaillance au niveau des composants peut provoquer la modification de la structure du système, et donc peut rendre une propriété structurelle insatisfaite. Ainsi, les propriétés structurelles sont écrites sous forme d’expressions booléennes basées sur l’état de fonctionnement des composants. En utilisant les expressions booléennes associées aux propriétés structurelles, leur fiabilité et/ou disponibilité peut être calculée sachant les caractéristiques de sûreté de fonctionnement des composants du système. À travers cette étude, nous pouvons vérifier si, pendant le temps de mission du système, une propriété structurelle restera satisfaite et/ou respectera un niveau de performance exigé par un cahier des chargesThis thesis concerns the development of analysis of structural properties in interaction with indicators of reliability. Our study focuses on (linear, bilinear or switching) structured systems, they must verify some important properties for the accomplishment of their mission. Properties depend on the structure of the system, hence the term "structural properties". The structure of the system can be represented by a graph consisting of vertices and edges. Verification of structural properties depends mainly on four basic conditions of connectivity, link distance and complete linkage. We have developed algorithms to express the form of Boolean expressions based on the edges of the graph representing the system. We consider that each edge is linked to the system components. A failure at the component level can cause changes in the structure of the system, and therefore can make a structural property unsatisfied. Thus, the structural properties are written as boolean expressions based on the operating state of the components. Using boolean expressions associated to the structural properties, reliability and / or availability can be calculated knowing the characteristics of the system components. Through this study, we can check if during the mission time of the system, a structural property remain satisfied and / or comply with a level of performance required by the specifications
7
Galvez, Manriquez Daniel. "Évaluation de la capacité à innover : une approche par auto évaluation et suivi supporté par des analyses multicritères dynamiques." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0018/document.
Full textAbstract:
L’un des challenges les plus importants des pays développés ou émergents est de soutenir l’innovation dans les PME. Mais la question centrale ici, est de savoir si l’innovation dépend exclusivement de la disponibilité des ressources. La capacité à innover ne dispose pas d'un cadre de référence pour son évaluation, en raison principalement de sa complexité et sa nature abstraite. Sans les indicateurs appropriés, il est impossible d'établir les objectifs et de déterminer les efforts et les ressources nécessaires pour améliorer la capacité d'innovation. Le laboratoire ERPI a développé une approche d’évaluation de cette capacité privilégiant les pratiques internes qui favorisent l’innovation dans les entreprises (IIP, Indice d’Innovation Potentielle) basée sur des méthodes d’analyse multicritère. Mais une fois obtenu un résultat, quels sont les points sur lesquels une entreprise peut jouer afin d’améliorer son système d'innovation ? Dans cette thèse, nous proposons un modèle d'optimisation qui réplique la procédure d'évaluation de la capacité à innover utilisée par l'IIP et qui nous permettra de générer un plan d'action pour améliorer la capacité à innover des PME. Le modèle considère différents facteurs (la situation particulière de l'entreprise, les efforts économiques associés à la stratégie proposée, etc.) afin de générer le plan d'action le plus approprié aux besoins de chaque PME. Ainsi, trois stratégies potentielles sont proposées : améliorer le classement actuel avec un minimum d'effort, maximiser les économies de ressources, maximiser l’IIP avec un budget défini. Des scénarii sont simulés afin de tester les résultats de la mise en œuvre des différentes stratégiesOne of the most important challenges in the current industrial policy of developed and emerging countries is to support innovation in SMEs, issue which has been approach as a problem only dependent on the availability of resources. Innovation capability does not have an appropriate framework of evaluation, mainly because of its complexity and abstract nature. Without proper indicators, it is not possible to establish objectives and identify the efforts and resources necessary for its improvement. In response to this, the ERPI laboratory has developed an evaluation approach of innovation capability, taking into account internal practices to promote innovation. A field of knowledge has been developed in this direction allowing for the proposal of a novel metrology, the Potential Innovation index (PII), based on multi-criteria analysis methods for studying the dynamics within companies. In this thesis, we propose an optimization model that replicates the evaluation procedure of innovation capability to generate an action plan, i.e., the model returns concrete points in which companies can work to improve its innovation system. The model considers factors such as the particular situation of the company, the economic efforts associated with the proposed strategy, the goals of the entrepreneur, etc. Three optimization strategies are proposed: access to a higher category with a minimum of effort, maximize resource efficiency and maximize innovation performance with a defined budget. Scenarios are simulated to test the results of the implementation of the different strategies
8
Sassi, Ons. "Planification de la recharge et optimisation des tournées dans le cas de flottes captives." Electronic Thesis or Diss., Université de Lorraine, 2015. http://www.theses.fr/2015LORR0303.
Full textAbstract:
Le véhicule électrique est actuellement au coeur des alternatives énergétiques qui permettent de faire face à la croissance du coût du carburant et au réchauffement climatique. En revanche, l’autonomie limitée des batteries des véhicules électriques et l’indisponibilité d’un nombre suffisant de bornes de recharge représentent des enjeux majeurs auxquels se trouvent confrontés les utilisateurs. Le déploiement des véhicules électriques doit alors passer par la conception et l’expérimentation des outils d’aide à la décision pour gestion optimisée et adaptée de l’écosystème du véhicule électrique. C’est dans ce contexte que s’inscrit cette thèse qui vise à fournir des outils d’aide à la décision pour l’optimisation des usages, de la recharge et des tournées des véhicules électriques dans le cadre industriel. Dans un premier temps, nous proposons d’étudier le problème d’optimisation conjointe de l’affectation et de la recharge des véhicules électriques. L’objectif de ce problème est de maximiser l’usage des véhicules électriques et minimiser les coûts de recharge tout en prenant en compte les contraintes d’ordre opérationnel et technique. Pour résoudre ce problème, nous proposons une méthode exacte et deux heuristiques. Nous comparons les performances de ces méthodes sur des instances réelles et d’autres aléatoires. Nous exposons ensuite plusieurs extensions au problème de base en intégrant de nouvelles fonctions objectif et de nouvelles contraintes. Nous étudions par la suite notre problème de point de vue ordonnancement et nous proposons une étude de complexité et des algorithmes d’approximation avec garantie de performance pour le problème d’ordonnancement d’intervalles sous contraintes d’énergie. Finalement, nous nous intéressons à un nouveau problème de construction de tournées pour une flotte mixte de véhicules électriques et thermiques. Pour résoudre ce problème, nous proposons des heuristiques et des méta-heuristiques hybrides et nous comparons les performances des différentes méthodes sur des instances généralisées de la littératureElectric Vehicles may decrease transportation-related emissions and provide for less dependence on foreign oil. However, electric vehicles are still facing many weaknesses related to the high purchase prices, limited battery range and scarce charging infrastructure. The deployment of electric vehicles must then involve the design and the deployment of charging infrastructures. Within this study, the overall objective is to provide enhanced optimization methods and decision tools for electric vehicles assignment, charging and routing that are relevant to different real-world constraints. Firstly, we propose to study the joint scheduling and optimal charging of electric vehicles problem. This problem consists in assigning a set of already constructed routes to the available electric and conventional vehicles and in, simultaneously, optimizing the electric vehicles charging costs while ensuring that all constraints are satisfied. The objective of this problem is to maximize the use of EVs and to minimize charging costs. Secondly, we propose different extensions to our baseline problem and we vary the objective functions and the considered constraints. Moreover, our problem can be seen as a fixed interval scheduling problem with complementary constraints of energy. We propose then to study the complexity and the approximability of many variants of this new problem. Finally, we consider a new variant of the electric vehicle routing problem with a heterogeneous fleet of vehicles and we propose different heuristics and metaheuristics to solve it. We test the different solving methods on benchmark instances and we evaluate the efficiency of each method
9
Ben, Mechlia Malek. "Dimensionnement et typologie d’une flotte de véhicules tenant compte de l’impact environnemental et de la maintenance." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0344.
Full textAbstract:
De nos jours, la logistique occupe une place importante dans la politique de pilotage des entreprises. Ceci est dû certainement aux exigences imposées par la partie prenante. Ces exigences ont entrainé les entreprises à explorer d’autres voies pour améliorer leurs performances économiques tout en respectant les exigences imposées. La clé de la réussite de la plupart des entreprises réside dans la bonne décision à prendre avant d’investir. Dans ce cadre, instaurer des outils d’aides à la décision en tenant compte des contraintes opérationnelles et environnementales dans le domaine de la logistique est devenu un enjeu majeur pour relever ce défi. À cet égard, nous nous sommes intéressés dans ce projet de recherche au dimensionnement d’un parc de véhicules en tenant compte de l’impact environnemental et de la maintenance tout en considérant deux types de véhicules (diesel, électrique). Une étude bibliographique des domaines de la logistique de transport, la maintenance, les caractéristiques des différents types de véhicule, a été réalisée dans un premier temps. La modalité d’exploitation, la consommation énergétique ainsi que l’impact environnemental causé par les moyens de transport selon son type, sont pris en considération dans la présentation des différentes études menées. Pour le dimensionnement et typologie d’une flotte de véhicules basés sur la maintenance et l’impact environnemental on a proposé trois stratégies où chacune est illustrée par le biais du développement d’un modèle analytique et une résolution numérique basée sur un exemple. Le premier modèle se rapporte à la stratégie d’achat et revente en fin de missions, le deuxième s’intéresse à la stratégie de leasing et le troisième concerne la stratégie d’achat, sous-traitance en fin de mission et revente à la fin du contrat de sous-traitance. L’optimisation de chaque stratégie est développée dans le but de déterminer essentiellement le nombre de véhicules à exploiter dans chaque type, le nombre de mois d’utilisation de chaque véhicule et la périodicité de maintenance préventive pour chacun. Les résultats numériques montrent les différences entre stratégies et prouvent la robustesse des modèles analytiques développés. On note qu’on a pris en considération l’impact d’une période de crise sanitaire (Covid-19) sur le plan de maintenance préventive pour la première stratégie développéeNowadays, taking into account hard customer requirements, logistics represent one of the most important key of success for companies. It is clear that the expectations have led companies to explore new ways to improve their economic performance while respecting the imposed requirements. In this context, introducing the decision support tools taking into account operational and environmental constraints in the logistics field has become a major issue to turn up this challenge. Therein, we were interested in this research project in the economical sizing of a fleet of vehicles taking into account the environmental impact and maintenance, while considering two types of vehicles (fuel, electric). The operating mode, the energy consumption as well as the environmental impact caused by the means of transport are taken into account in presenting the various works studied. For the sizing and typology of a vehicle fleet based on maintenance and environmental impact we proposed three strategies, where each is illustrated through the development of an analytical model and a numerical resolution based on an example. The first relates to the strategy of acquisition and resale of all vehicles used at the end of missions, the second is about the strategy of leasing and the third concerns the strategy of acquisition, the subcontracting at the end of missions and resale at the end of the subcontracting contract. The optimization of each strategy is developed in order to determine the optimal number of vehicles of each type to be exploited, the duration of its use, and the preventive maintenance (PM) policy to be adopted for each types of vehicles. Numerical results show the differences between strategies and prove the robustness of the analytical models developed. We note that the impact of the period of health crisis (Covid-19) on the preventive maintenance strategy has been taken into consideration for the first strategy developed
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Burga, Reyes Alexandra. "Aplicativo móvil con realidad aumentada para apoyar el aprendizaje del área de ciencia y ambiente para niños de 4 años del nivel inicial de la Institución Educativa Augusto Salazar Bondy." Bachelor's thesis, Universidad Católica Santo Toribio de Mogrovejo, 2019. http://hdl.handle.net/20.500.12423/2709.
Full textAbstract:
En la presente tesis, se plantea el problema de ¿Cómo apoyar el aprendizaje del área de Ciencia y Ambiente para niños de 4 años del nivel inicial de la institución educativa Augusto Salazar Bondy?, teniendo como objetivo principal apoyar el aprendizaje del área de Ciencia y Ambiente mediante el desarrollo de un aplicativo móvil con realidad aumentada para niños de 4 años del nivel inicial, como sustento al objetivo principal se consideraron a los siguientes objetivos específicos:
• ‘Implementar un aplicativo móvil con realidad aumentada para mejorar la competencia de indagar mediante métodos científicos sobre los seres vivos observándolos y expresando de manera gráfica lo aprendido’, para lo cual se implementó en el aplicativo móvil con realidad aumentada el módulo de los ‘Animales de granja’.
• ‘Implementar un aplicativo móvil con realidad aumentada para mejorar la competencia de explorar el mundo físico, basado en conocimientos científicos permitiendo a los niños describir y relacionar las características observadas’, para lo cual se implementó en el aplicativo móvil con realidad aumentada el módulo de las ‘Estaciones del año’.
Como resultados de la investigación se obtuvo que la implementación del aplicativo móvil con realidad aumentada para el área de Ciencia y Ambiente apoyó en el aprendizaje de los niños de 4 años del nivel inicial de la institución educativa Augusto Salazar Bondy.
Books on the topic "914.25/4/003"
1
Пастух, Тарас. Роман "Місто" Валер"яна Підмогильного. Луганськ: Книжковий світ, 1999.
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2
Риплей, А. Скарлетт. Санкт-Петербург: Братство, 1992.
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3
Волноходец, Г. Седые паруса. Санкт-Петербург: Культура, 2004.
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4
Нидал, Лама Оле. Открытие Алмазного пути тибетский буддизм встречается с Западом. Санкт-Петербург: Алмазный Путь, 2001.
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5
Eldering, Jaap. Normally Hyperbolic Invariant Manifolds. Paris: Atlantis Press, 2013. http://dx.doi.org/10.2991/978-94-6239-003-4.
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6
Agung, Indonesia Mahkamah. Keputusan bersama Ketua Mahkamah Agung RI dan Menteri Agama RI nomor KMA/001/SK/I/1983 dan nomor 1 tahun 1983, nomor KMA/002/SK/I/1983 dan nomor 2 tahun 1983, nomor KMA/003/SK/I/1983 dan nomor 3 tahun 1983, nomor KMA/004/SK/I/1983 dan nomor 4 tahun 1983, dan Peraturan Menteri Agama RI nomor 1 tahun 1983 Tentang Pemberi Bantuan Hukum pada Peradilan Agama. [Jakarta]: Departemen Agama RI, Ditjen Binbaga Islam, Ditbinbapera Islam, 1989.
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7
6103007414. Electric Sales and Revenue, 1990/Stk No 061-003-00741-4. United States Government Printing, 1992.
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8
County Business Patterns: Indiana, 1988/Stk No 003-024-07130-4. Government printing office, 1991.
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9
The Survey of English Place-Names: Part 7. English Place-Name Society, 2009.
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10
3010001984. Business Statistics, 1961-88: A Supplement to the Survey of Current Business/Stk. No. 003-010-00198-4 (Business Statistics). 2nd ed. U.S. Government Printing Office, 1990.
Find full textBook chapters on the topic "914.25/4/003"
1
Faraday, Martha M. "Stress Revisited." In Nutrients, Stress, and Medical Disorders, 3–19. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1385/1-59259-952-4:003.
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Goumnerova, Liliana C. "Endoscopic Techniques, Equipment, and Optics." In Minimally Invasive Neurosurgery, 3–11. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-899-4:003.
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CRUZ, M. F. S. J., G. M. PEREIRA, A. da S. SANTOS, and C. H. F. CRUZ. "INVESTIGAÇÃO QUÍMICA, ATIVIDADES BIOLÓGICAS E APLICAÇÕES DE POLISSACARÍDEOS EM PRODUTOS NATURAIS." In Produtos Naturais: Etnobotânica, Estudos Químicos e Aplicações, 48–65. Arco Editores, 2022. http://dx.doi.org/10.48209/978-65-5417-003-4.
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4
"Front Matter." In A Guide to Designing Welds, 3. Elsevier, 2000. http://dx.doi.org/10.1016/b978-1-85573-003-8.50001-4.
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Hicks, John. "Non-destructive testing." In A Guide to Designing Welds, 56–58. Elsevier, 2000. http://dx.doi.org/10.1016/b978-1-85573-003-8.50015-4.
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Groppo, Veronica. "La sepoltura equina 49 dell’Opera Pia Moro e la sua bardatura." In Figlio del lampo, degno di un re. Un cavallo veneto e la sua bardatura Atti della giornata di studi (Oderzo, 23 novembre 2018). Venice: Fondazione Università Ca’ Foscari, 2022. http://dx.doi.org/10.30687/978-88-6969-637-4/003.
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The horse grave 49 of the southern cemetery Opera Pia Moro in Oderzo, found buried in a small independent mound, wore a rich iron and bronze harness, with iron and wood U-posts. The deposition is given in the second half of the 5th century BC and finds comparisons in Europe, especially in the French Marne area, between the age of Ha C and LT A-B1.
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Dal Poz, Lorena. "La costruzione delle competenze regionali nella tutela del patrimonio bibliografico." In Dalla tutela al restauro del patrimonio librario e archivistico. Venice: Edizioni Ca' Foscari, 2018. http://dx.doi.org/10.30687/978-88-6969-215-4/003.
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The essay focuses upon the issues and the evolution of protecting library materials by the Italian Regions since 1972, when the state law delegated to them this activity. The activities carried out by the regional authority had a positive outcome until 6 August 2015 when through a State law n.125 the authority regarding the protection of library material returned to the central competence.As well as the printed bibliography, also sources from the regional archives and the direct experience of the author have been used, as she was from 2006 Head of Regional Office of the Superintendent Book Heritage of the Veneto Region. Successful examples since 2003 carried out by the Office activities to protect the library cultural heritage will also presented. The author hopes for close cooperation between the National office who has now taken the responsibility to take care of the library heritage material in Veneto and the and regional Office in order to keep the knowledge and expertise developed by the latter throughout years of close collaboration with the institutions based on its territory.
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Marcato, Enrico. "Onomastic Catalogue." In Antichistica. Venice: Edizioni Ca' Foscari, 2018. http://dx.doi.org/10.30687/978-88-6969-231-4/003.
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Caon, Fabio. "Un modello di riferimento per l’analisi della comunicazione interculturale tra italiani e sudanesi." In Between Languages and Cultures. Intercultural Communication between the Italians and Sudanese. Venice: Edizioni Ca' Foscari, 2018. http://dx.doi.org/10.30687/978-88-6969-244-4/003.
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Tani, Irene. "3 Nota al testo." In Le Rime di Bernardo Cappello. Venice: Edizioni Ca' Foscari, 2018. http://dx.doi.org/10.30687/978-88-6969-257-4/003.
Full textConference papers on the topic "914.25/4/003"
1
Chen, Amy, Min Li, Emma RB Sangalang, Danielle Fontaine, Tiffany Chou, Mingrui An, Maja Bonacorsi, et al. "1121 TAC-003, a TLR9 agonist antibody conjugate for targeted immunotherapy of Nectin-4 expressing tumors." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.1121.
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Bruserud, Kjersti. "Simultaneous Stochastic Model of Waves and Currents for Prediction of Structural Design Loads." In ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-77219.
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Simultaneous data of metocean parameters, such as wind, waves and current, of sufficient quality and duration are necessary to establish reliable, joint models of metocean loads and load effects on marine structures. In lack of such joint models, the Norwegian design standard, NORSOK N-003, recommends combinations of metocean parameters for load estimations assumed to be conservative. However, the degree of conservatism is rather uncertain. The possible conservatism in NORSOK N-003 for combinations of wave and current conditions in the northern North Sea has been assessed. To perform such an assessment, precise knowledge about the wave and current conditions is required, as well as simultaneous wave and current data of high quality and long duration. Available measured wave and current data during nearly five years, at selected locations in the northern North Sea, are described. A thorough assessment of the current conditions at these locations is given, with the following important findings; (1) the quality of measured current data is poorer than anticipated, (2) the dominating current conditions at some locations is wind-generated inertial oscillations, (3) the seasonality of current conditions at these locations is very distinct due to the inertial oscillations and (4) significant inter-annual variations in current conditions is found. For waves in the northern North Sea, both measured and hindcast data are found to be of appropriate quality and duration for joint considerations, but neither current measurements nor hindcast have the required quality or duration. To generate adequate current data, a simple model for wind-generated inertial oscillations is applied and validated at one location in the northern North Sea. With that, simultaneous wave and current data of sufficient quality and duration for joint modelling are available and a joint conditional model for waves and currents is proposed. The anticipated conservatism in NORSOK N-003 for load estimations is assessed by a case study. A simplified model for a generic static load on a jacket, caused by waves and currents, is assumed. For the northern North Sea, metocean loads are estimated first according to the NORSOK N-003 recommendation, and then directly from a load times series. Comparison of the two different approaches gives a clear indication that the NORSOK recommendation is not necessarily conservative in the northern North Sea. Due to several simplifications in the steps leading up to the load estimations, this result is intended to be illustrative.
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"3rd International Conference of the Society for Interdisciplinary Placebo Studies (SIPS): Harnessing Placebo Mechanisms for Optimal Pain Management and Treatment of Alcohol and Other Drug Use Disorders." In 3rd International Conference of the Society for Interdisciplinary Placebo Studies (SIPS): Harnessing Placebo Mechanisms for Optimal Pain Management and Treatment of Alcohol and Other Drug Use Disorders. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-003-4.
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Drohan, Megan, Christina Schulz, Emily Glatt, Amy Stamates, and Michelle Kelley. "Impulsivity and Childhood Physical Abuse Predict Past 30-day Cannabis Use Among Bisexual Women." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.11.
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Previous research suggests that bisexual women’s rate of cannabis use is 2 to 7 times higher than their heterosexual peers; however, factors contributing to this are unclear. Trait impulsivity (i.e., tendency to act without forethought) and history of childhood physical abuse (CPA) are two risk factors that may be relevant for bisexual women’s cannabis use. Specifically, bisexual women indicate high levels of risk-taking and commonly report histories of CPA. While both impulsivity and CPA have been identified as predictors of cannabis use in heterosexual women, research has yet to explore these factors as predictors of cannabis use among bisexual women. Consequently, the present study examined CPA and trait impulsivity as predictors of cannabis use in a sample of bisexual women. It was hypothesized that both trait impulsivity and exposure to CPA would predict greater frequency of cannabis use. Participants were 225 bisexual women aged 22.77 years (SD = 3.45) recruited from a southeastern university and community area. Participants completed an online survey including questions about their past 30-day frequency of cannabis use (5-point scale ranging from 0 = never to 4 = daily), CPA using the Child Maltreatment Scale-physical abuse subscale, and impulsivity using the Barratt Impulsiveness Scale-version 11. A majority of the sample reported cannabis use in the past 30 days (60.3%), with 23.2% using once or twice, 12.9% using weekly, 11.2% using almost daily, and 12.9% using daily. To account for the large number of zero values on the cannabis use score, we tested a Poisson hurdle model to evaluate the effects of CPA and impulsivity on cannabis use. Frequency of cannabis use was modeled first as a binary logistic model (0 versus any use) and then as a truncated regression model for non-zero responses. Results indicated that across all participants, greater impulsivity predicted any cannabis use in the past 30 days (p = .003), but CPA did not (p = .942). Among participants who reported past 30-day cannabis use only, CPA was associated with increased frequency of cannabis use (p = .003), and impulsivity did not predict frequency of cannabis use (p = .683). Overall, results indicated that greater trait impulsivity was associated with past 30-day cannabis use, but not frequency of cannabis use. Conversely, greater CPA exposure was not associated with whether one used cannabis in the past 30 days but instead was related to increased frequency of past 30-day cannabis use. Thus, although trait impulsivity may identify cannabis users, CPA may identify sexual minority women who are at risk for increased frequency of cannabis use. Given the potential long-term harms associated with increased cannabis use (e.g., changes in brain morphology, cognitive impairment, and respiratory issues), prevention efforts targeting bisexual women may want to consider impulsivity and CPA.
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Martin, Maurice, Stefan Winkler, and Frederik Belien. "Towards New V&V in AOCS/GNC for Industrial Efficiency." In ESA 12th International Conference on Guidance Navigation and Control and 9th International Conference on Astrodynamics Tools and Techniques. ESA, 2023. http://dx.doi.org/10.5270/esa-gnc-icatt-2023-171.
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Current and future space missions require increasingly more complex AOCS/GNC designs. Multiple drivers can be identified for this trend, such as larger deployable structures and the extended operational range due to more autonomous spacecraft. For each of these control problems, tailored solutions have to be developed with stringent performance requirements, while staying within time and cost constraints. The drivers highlight the need for efficient analysis tools that can support the Verification and Validation (V&V) process of AOCS/GNC systems. As pointed out in [1], the design phase of a project roughly takes about 20% of the total time, while the remaining 80% are used for planning and executing V&V activities. The increasing system complexity will only make this V&V gap worse. Thus, reducing the V&V effort through enhanced methods is a promising field for improved industrial efficiency. This paper presents the continued work on this topic building on the Airbus contribution to the multi-agency workshop & seminar series [2], [3]. A systematic and detailed framework to assess the robust stability and performance of uncertain systems is proposed, which aims to reduce the V&V engineering effort. Common V&V approaches often rely on large-scale simulation campaigns to cover the various system uncertainties in form of probabilistic Monte Carlo analyses. This process is very time consuming for complex simulations, does not give insights into the uncertainties that drive the stability and performance requirements, and might fail to identify critical scenarios. An alternative is to focus on worst-cases through analytical robustness analysis. Although techniques, such as the μ-analysis, have been available for decades, they have not been integrated into standard industrial processes. To facilitate the use of robustness analysis techniques, a step-by-step approach has been developed that results in an enhanced V&V framework. This framework combines various V&V techniques including worst-case analysis, sensitivity analysis, and optimization within both the time and frequency domain. It consists of 1) modelling the uncertainties through the Linear Fractional Transform (LFT) framework and forming the models from the LFT for stability and performance metrics, 2) defining the robustness metrics under analysis 3) identifying system driving uncertainties through a sensitivity analysis, 4) computing the worst-case degradation of the stability and performance metrics, and 5) performing analysis on the nonlinear simulator. The steps 1) - 4) are all performed within the frequency domain, whereas the last step is computed in the time domain. If the current control design fails the requirements, the obtained worst-cases can be used to synthesize a robust controller. To illustrate the steps in the enhanced V&V framework, an analysis on the robust attitude performance based on MetOp-SG (SAT-B) is presented. The uncertain multi-body dynamics are modelled according to the modular concept in [4] resulting in a compact LFT form. This model is used to analyse the degradation of stability metrics, such as gain, phase, and modulus margin, and performance metrics, such as pointing metrics defined in [5]. Additionally, the uncertainties that are driving these degradations are identified. This information is useful to further improve the control design and can be used as a model reduction technique for the LFT. Finally, the resulting worst-cases from the frequency domain are compared with nonlinear simulations in the time domain. Lastly, conclusions will be drawn how the enhanced V&V framework can potentially improve the current industrial standards. This comparison identifies future work that is necessary to pave the way for increased industrial efficiency in the future. [1] Dennehy, C., Bennani, S., Shankar, U., Vandersteen, J., and VanZwieten, T., “Verification and Validation (V&V) of Guidance & Control Systems: Restults From The First Inter-Agency Workshop [2] Winkler, S., Chapman, P., Juanpere, X. M., Ott, T., “AOCS/GNC Challenges, Solutions and Beyond: Engineering Passion versus for Industrial Efficiency”, Multi-Agency Workshop & Seminar Series, 2021. [3] Martin, M., Belien, F., Winkler, S., „Towards Increased AOCS/GNC Industrial Efficiency: Robust Performance Analysis Considering Real Mission Constraints”, Multi-Agency Workshop & Seminar Series, 2021. [4] Alazard, D., Sanfedino, F., “Satellite dynamics toolbox for preliminary design phase” In : 43rd Annual AAS Guidance and Control Conference, 2020. [5] ESSB-HB-E-003 Working Group, “ESA pointing error engineering handbook ESSB-HB-E-003,” Tech. rep., ESA, 2011.
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Жиронкин, С. А., М. А. Гасанов, and Р. Э. Гасанов. "ЦИФРОВИЗАЦИЯ КАК ДРАЙВЕР РАЗВИТИЯ НЕОИНДУСТРИАЛЬНОГО ТЕХНОЛОГИЧЕСКОГО БАЗИСА ЭКОНОМИКИ." In Цифровизация – драйвер экономического роста в постпандемический период: Всероссийская научно-практическая конференция с международным участием. РИЦ ХГУЭП, 2021. http://dx.doi.org/10.38161/978-5-7823-0742-4-2021-003-010.
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В последние десятилетия цифровые и интеллектуальные технологии все больше выступают драйвером и определяют траекторию развития современной рыночной экономики. В ее рамках осуществляется максимизация количества новой информации и минимизация количества традиционных факторов в производстве, распределении и потреблении товаров и услуг. Принципиальным является тот факт, что информация проникает во все сферы воспроизводственного процесса и создает мультипликативный эффект в рыночной экономике.
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Wen, Ange, Chuanchuan Shen, Chunyong Hao, and Jinyang Zheng. "Experimental Investigation on Burst Pressure and Fatigue Life of Type IV LPG Cylinders." In ASME 2020 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/pvp2020-21264.
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Abstract Compared with the steel cylinders for liquefied petroleum gas (LPG), fully-wrapped fiber reinforced cylinders with non-metallic liners (type IV cylinders) have been widely used due to their advantages of light weight, corrosion resistance, low maintenance cost and no explosion when exposed in fire. However, for the heterogeneity of raw material performances and instability of manufacturing process, the mechanical performances of type IV cylinders show a certain dispersion. Therefore, in this study, a series of burst tests and pressure cycle tests on 89 type IV LPG cylinders (26.2 L, 2.1 MPa) were conducted to examine the performances of burst pressure and number of pressure cycles, and analyze the distribution characteristics. The total length of the experimental cylinder was 465 mm, the outer diameter and the thickness of the liner was 304 mm and 2 mm, respectively. Two types of cylinders were tested, with the thickness of composite overwrap in 2 mm and 4 mm, corresponding to the designed burst pressure of 12 MPa and 15 MPa. Burst test and pressure cycle test were conducted according to the standard GB/T 15385 and GB/T 9252, respectively. Results showed that the 59 cylinders had the similar crevasses morphology along the axial wall of liners after burst tests. Burst pressure of two design types fluctuated within the range of 11.4 MPa-12.5 MPa, and 13.7 MPa-16.0 MPa, respectively. The statistical results of burst pressure showed approximately normal distribution with a standard deviation of 0.263 MPa and 0.529 MPa. Also, the number of pressure cycles of 30 cylinders were all above 12,000 with a cycle frequency no more than 15 cycles per minute. Above studies have provided a data support for the recently published Chinese association standard T/CATSI 02 003-2019.
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Huang*, Chao, Liang-guo Dong, and Yu-zhu Liu. "Full-waveform microseismic source location using improved scattering-integral approach." In 2017 Workshop: Microseismic Technologies and Applications, Hefei, China, 4-6 June 2017. Society of Exploration Geophysicists, 2017. http://dx.doi.org/10.1190/microseismic2017-003.
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Argyriou, Konstantinos, Richard Ingram, Rachel Blatt, Patrick Wilson, Sunil Samuel, Christopher Hawkey, and Gordon Moran. "PWE-003 Acetarsol is an effective option in the management of refractory proctitis." In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.135.
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Ahmad, Ahmir, Juliet Bottle, Anthony Laverty, Sam Murray, and Iain Ewing. "PTH-003 QIP: improving quality of photodocumentation and lesion reporting in upper gastrointestinal endoscopy." In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.25.
Full textReports on the topic "914.25/4/003"
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Leis, Brian, and Xian-Kui Zhu. PR-003-063509-R01 Models for Predicting Delayed Fatigue Failure of Pipelines at Mechanical Damage. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), May 2018. http://dx.doi.org/10.55274/r0011489.
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Because where potentially serious damage is found it is dug and dealt with, models that assess damage severity have no relevance in that context. But, as in-line inspection tools become better adept in identifying and characterizing potential damage, models will be needed to screen the ILI results, to determine whether a dig is warranted, and when that must happen. While criteria like B31G might be used to assess metal loss due to a gouge, the usual complexity of mechanical damage cannot be assessed simply in terms of length and depth, so validated models that can account for the complexity are required. Such models could then be evaluated parametrically to develop prioritization guidelines useful with modern inspection technologies. PRCI Projects MD-4-3 and MD-4-4 were initiated to develop such models, with the results of full-scale testing generated in Project MD-4-1 serving as the basis to assess their validity. This report presents the work done as part of PRCI Project MD-4-4, which targeted an improved model for predicting time and/or cycle-dependent failure of dent and gouge damage. In addition to meeting that objective, this project also developed the basis to predict immediate failure consistent with the scope of Project MD-4-1, which as of this reporting had not emerged from the work of Project MD-4-3. Technology framed in the context of PR3-9305 was used to predict the immediate failure due to burst testing of gouged pipe done as part of MD-4-1, and found to accurately predict those collapse-controlled failures. Technology framed in that same context also was used to predict the delayed failure due to fatigue that developed in cyclic pressure testing of gouged pipes that also was done as part of MD-4-1, and found to reasonably predict those outcomes. However, there were some results that indicated the need to better quantify the crack driving force in terms of re-rounding, and the population of defects that can develop when the damaged pipe re-rounds in the wake of damage.