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Academic literature on the topic '833/.6'

Author: Grafiati

Published: 29 July 2024

Last updated: 30 July 2024

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Journal articles on the topic "833/.6"

1

Dorr, R., C. Karanes, C. Spier, T. Grogan, J. Greer, J. Moore, B. Weinberger, et al. "Phase I/II Study of the P-Glycoprotein Modulator PSC 833 in Patients With Acute Myeloid Leukemia." Journal of Clinical Oncology 19, no. 6 (March 15, 2001): 1589–99. http://dx.doi.org/10.1200/jco.2001.19.6.1589.

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PURPOSE: To determine the maximum-tolerated dose, pharmacokinetic interaction, and activity of PSC 833 compared with daunorubicin (DNR) and cytarabine in patients with poor-risk acute myeloid leukemia. PATIENTS AND METHODS: Patients received ara-C 3 g/m2/d on 5 consecutive days, followed by an IV loading dose of PSC 833 (1.5 mg/kg) and an 84-hour continuous infusion escalating from 6, 9, or 10 mg/kg/d. Daunorubicin was administered as a 72-hour continuous infusion at 34 or 45 mg/kg/d. Responding patients received consolidation chemotherapy with DNR pharmacokinetics performed without PSC-833 on day 1, and with PSC-833 on day 4. Response was correlated with expression of P-glycoprotein and lung resistance protein (LRP), and in vitro sensitization of leukemia progenitors to DNR cytotoxicity by PSC 833. RESULTS: All 43 patients are assessable for toxicity and response. Grade 3 or greater hyperbilirubinemia (70%) was the only dose-dependent toxicity. Four patients (9%) succumbed to treatment-related complications. Twenty-one patients (49%) achieved a complete remission or restored chronic phase, including 10 of 20 patients treated at the maximum-tolerated dose of 10 mg/kg/d of PSC-833 and 45 mg/m2 of DNR. The 95% confidence interval for complete response was 33.9% to 63.7%. Administration of PSC 833 did not alter the mean area under the curve for DNR, although clearance decreased approximately two-fold (P = .04). Daunorubicinol clearance decreased 3.3-fold (P = .016). Remission rates were not effected by mdr-1 expression, but LRP overexpression was associated with chemotherapy resistance. CONCLUSION: Combined treatment with infused PSC 833 and DNR is well tolerated and has activity in patients with poor risk acute myeloid leukemia. Administration of PSC 833 delays elimination of daunorubicinol, but yields variable changes in DNR systemic exposure.

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Bajelan, Elmira, Azadeh Haeri, Amir Masoud Vali, Seyed Nasser Ostad, and Simin Dadashzadeh. "Co-delivery of Doxorubicin and PSC 833 (Valspodar) by Stealth Nanoliposomes for Efficient Overcoming of Multidrug Resistance." Journal of Pharmacy & Pharmaceutical Sciences 15, no. 4 (October 15, 2012): 568. http://dx.doi.org/10.18433/j3sc7j.

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Purpose. This study was aimed at developing co-encapsulated stealth nanoliposomes containing PSC 833, an efficient MDR modulator, and doxorubicin (DOX) in order to increase the effectiveness and decrease adverse effects of the anticancer drug. Methods. In attempt to increase the encapsulation efficiency of drugs, different methods for liposome preparation were tested and the effect of different parameters such as drug to lipid molar ratio, cholesterol mole percent and lipid compositions, were investigated. The final product with a lipid composition of EPC:DSPE-PEG2000:Chol (60:5:30 %mol) was prepared by thin layer film hydration method. After preparation of empty liposomes, DOX and PSC 833 were loaded using ammonium sulfate gradient and remote film loading methods, respectively. Physical characteristics of optimized liposomes (DOX/PSC-L) such as particle size, zeta potential, encapsulation efficiency, in-vitro drugs release and stability were evaluated. Furthermore, in vitro cytotoxicity study of various liposomal formulations as well as drugs, solutions against resistant human breast cancer cell line, T47D/TAMR-6, was evaluated using MTT assay. Results. The best formulation showed a narrow size distribution with average diameter of 91.3 ± 0.2 nm with zeta potential of -6 ± 1.2, the encapsulation efficiency for DOX and PSC 833 were more than 95% and 65.5%, respectively. In DOX-resistant T47D/TAMR-6 cells, dual-agent stealth liposomes showed significantly greater cytotoxicity (P < 0.05) than free DOX and liposomal DOX plus free PSC 833 treatments. Conclusions. Co-encapsulation of DOX and PSC 833 presents a promising anticancer formulation, capable of effective reversal of drug resistance, and should be explored further in therapeutic studies with animal tumor xenograft models. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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van der Holt, Bronno, Pieter Sonneveld, Alan K. Burnett, Paula J. M. Vossebeld, Berna Beverloo, Gerd Rosenkranz, Margaret Dugan, Wim L. J. van Putten, Keith Wheatley, and Bob Lowenberg. "Daunorubicin and Cytarabine Compared with Daunorubicin, Cytarabine and the MDR1 Reversal Agent PSC-833 in Elderly Patients with Acute Myelogenous Leukemia." Blood 104, no. 11 (November 16, 2004): 863. http://dx.doi.org/10.1182/blood.v104.11.863.863.

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Abstract Older patients (pts) have a high incidence of P-glycoprotein (P-gp) positive AML blast cells. P-gp acts as drug efflux pump for a variety of agents including daunorubicin (DNR). The P-gp inhibitor PSC-833 can inhibit the function of P-gp in AML cells and restore sensitivity to DNR. Combining PSC-833 with DNR may improve response rate and survival in AML pts. However, previous intervention studies have produced conflicting results. From 1997 to 1999 we conducted a multi-center phase 3 study in pts of older age with previously untreated AML, in which we prospectively investigated the effect of PSC-833 combined with standard antileukemic treatment in relation to the flowcytometric P-gp status at diagnosis. Pts were randomized to receive two cycles of DNR (45 mg/m2, days 1-3) and Ara-C (200 mg/m2, 7 days) or the same regimen with a lower dose of DNR (35 mg/m2, days 1–3) plus PSC-833 (2 mg/kg loading dose followed by 10 mg/kg/24h for 72 hours). Pts who attained a complete remission (CR) were to receive a common consolidation cycle of Ara-C (1 g/m2, days 1–4), mitoxantrone (6 mg/m2, days 1–4) and etoposide (80 mg/m2, days 1–4). Results. 428 pts were randomized (214 in each arm) with 419 eligible and evaluable. Median age was 67 years (range 58–85). Baseline characteristics were comparable between the two arms. Cytogenetics was successfully performed in 293 pts; 5 had favorable and 66 had unfavorable abnormalities. P-gp expression was assessed in fresh, purified bone marrow samples of 309/419 pts (74%) by determining the Rhodamin123 efflux ratio with/without PSC-833 in vitro and by assessment of the UIC2 and MRK16 expression ratios. Upon P-gp assessment combining the 3 tests, pts were classified as P-gp negative (27%), low positive (29%), positive (28%) or highly positive (17%). Median follow up is 56 months. CR and 5-year survival rates with 95% confidence intervals are in the table below. Increased P-gp expression was associated with a lower CR rate (P=0.02), worse event-free survival (EFS) and overall survival (OS), P=0.01. There was also no significant effect of PSC-833 on the CR rate, OS, EFS or disease-free survival (DFS) when P-gp status was included in a multivariate analysis. In the planned subgroup analysis of pts with P-gp expression, who were expected to benefit most from PSC-833, CR rate was somewhat higher in the PSC arm (61% vs. 51%, P=0.07), however, OS, EFS and DFS were not different (P=0.8, 0.9 and 0.15). Analysis of frequently occurring polymorphisms of P-gp in exons 12, 21 and 26 revealed that pts who had wildtype genotype alleles in all 3 exons had a relatively poor survival as compared with those with heterozygous or homozygous mutant alleles in all 3 exons. Conclusions. Addition of PSC-833 to DNR and Ara-C does not improve CR rate nor long-term OS, EFS and DFS in elderly AML pts. P-gp expression remains an independent adverse prognostic factor in AML pts treated with P-gp reversal. Results by treatment arm control (n=211) PSC-833 (n=208) P-value CR 48% (41–55) 54% (47–61) 0.22 EFS 8% (5–13) 7% (4–11) 0.46 DFS 17% (11–26) 13% (8–20) 0.06 10% (6–15) 10% (6–15) 0.52

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4

Aguiluz, A., E. Navarro, F. Guerra, H. Córdova, and A. Oyervides. "Evaluación de cuatro ciclos de selección para resistencia al achaparramiento del maíz en la población 73." Agronomía Mesoamericana 6 (June 2, 2016): 88. http://dx.doi.org/10.15517/am.v6i0.24811.

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Twelve corn (Zea mays L.) cultivars were evaluated under two environments in Central America and one in Mexico in order to determine the genetic progress achieved for resistance to stunting, after four selection cycles of the population 73. The trial included the synthetics from the cycles 0, 1,2,3 and 4, composites from the cycles 2, 3 and 4, three tolerant control s N8-6, Santa Rosa 8073 and the hybrid H-53, and a susceptible control (hybrid 8-833). The percent averages of stunted plants were relatively low (between 10 and 20 %) at the three localities. The cycle 4 synthetic yielded an average (4214 kg/ha) statistically alike to the hybrids 8-833 and H-53 (4288 and 4030 kg/ha, respectively). The cycle 4 synthetic showed the lowest stunting percentage (8.9%), the commercial tolerant variety NB-6 showed 16.2% and the susceptible hybrid (B-833) 22.8%. A lineal regression between yield averages and the selection cycles reveal an average gain per cycle of 149 kg/ha (4.3 % per cycle) and a reduction per cycle of 2% of stunted plants (11 % gain/cycle). It is concluded that the proceedings among S1 lines has been effective in improving the performance of population 73, increasing productivity of grain yield and the stunting resistance.

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Łukaszewski, Jakub. "Michał Spandowski, Catalogue of Incunabula in the National Library of Poland, in collaboration with Sławomir Szyller, description of bookbindings prepared by Maria Brynda, translation: Elżbieta Olechowska, vol. I, Warszawa: Biblioteka Narodowa 2020, s. 694 [1]. ISBN 978-83-7009-833-6." Biblioteka, no. 25 (34) (December 30, 2021): 265–80. http://dx.doi.org/10.14746/b.2021.25.14.

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Recenzja: Michał Spandowski, Catalogue of Incunabula in the National Library of Poland, in collaboration with Sławomir Szyller, description of bookbindings prepared by Maria Brynda, translation: Elżbieta Olechowska, vol. I, Warszawa: Biblioteka Narodowa 2020, s. 694 [1]. ISBN 978-83-7009-833-6

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6

Tharanya, Murugesan, Kaliamoorthy Sivasakthi, Gloria Barzana, Jana Kholová, Thiyagarajan Thirunalasundari, and Vincent Vadez. "Pearl millet (Pennisetum glaucum) contrasting for the transpiration response to vapour pressure deficit also differ in their dependence on the symplastic and apoplastic water transport pathways." Functional Plant Biology 45, no. 7 (2018): 719. http://dx.doi.org/10.1071/fp17161.

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Genotypic differences in transpiration rate responses to high vapour pressure deficit (VPD) was earlier reported. Here we tested the hypothesis that this limitation could relate to different degrees of dependence on the apoplastic (spaces between cells), and symplastic water transport pathways (through cells via aquaporin-facilitated transport), which are known to have different hydraulic conductivities. The low transpiration rate (Tr) genotype PRLT 2/89/33 either restricted its transpiration under high VPD, or was more sensitive to VPD than H77/833-2, when grown hydroponically or in soil. The slope of the transpiration response to an ascending series of VPD was lower in whole plants than in de-rooted shoots. In addition, the transpiration response of detached leaves to moderately high VPD (2.67 kPa), normalised against leaves exposed to constant VPD (1.27 kPa), was similar in low and high Tr genotypes. This suggested that roots hydraulics were a substantial limitation to water flow in pearl millet, especially under high VPD. The dependence on the apoplastic and symplastic water transport pathways was investigated by assessing the transpiration response of plants treated with inhibitors specific to the AQP-mediated symplastic pathway (AgNO3 and H2O2) and to the apoplastic pathway (precipitates of Cu(Fe(CN)6) or Cu(CuFe(CN)6)). When CuSO4 alone was used, Cu ions caused an inhibition of transpiration in both genotypes and more so in H77/833-2. The transpiration of high Tr H77/833-2 was decreased more by AQP inhibitors under low VPD (1.8 kPa) than in PRLT 2/89/33, whereas under high VPD (4.2 kPa), the transpiration of PRLT 2/89/33 was decreased more by AQP inhibitors than in H77/833-2. The transpiration rate of detached leaves from H77/833-2 when treated with AgNO3 decreased more than in PRLT 2/89/33. Although the root hydraulic conductivity of both genotypes was similar, it decreased more upon the application of a symplastic inhibitor in H77/833-2. The transpiration of low Tr PRLT 2/89/33 was decreased more by apoplastic inhibitors under both low and high VPD. Then the hydraulic conductivity decreased more upon the application of an apoplastic inhibitor in PRLT 2/89/33. In conclusion, both pathways contributed to water transport, and their contribution varied with environmental conditions and genotypes. Roots were a main source of hydraulic limitation in these genotypes of pearl millet, although a leaf limitation was not excluded. The similarity between genotypes in root hydraulic conductivity under normal conditions also suggests changes in this conductivity upon changes in the evaporative demand. The low Tr genotype depended more on the apoplastic pathway for water transport, whereas the high Tr genotype depended on both pathway, may be by ‘tuning-up’ the symplastic pathway under high transpiration demand, very likely via the involvement of aquaporins.

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7

Аббасов, Рамиг Тофиг, and Мехрибан Расим Агаева. "Studying the Growth and Development of Hybrids Cows." Bulletin of Science and Practice, no. 8 (August 15, 2022): 69–74. http://dx.doi.org/10.33619/2414-2948/81/11.

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Исследования были проведены в учебном центре животноводства и коневодства Азербайджанского государственного аграрного университета. Изучались несколько пород коров. В возрасте 6 месяцев средний вес представителей симментальской породы составлял 175 кг, голштинской - 163 кг, симментальская × голштинская - 171 кг, абердин-ангусская × голштинская - 178 кг, Шароле × голштинская - 176 кг и зебу × симментальская - 192 кг. Целью исследования стало определение генотипа с оптимальным результатом роста и развития. В результате вскармливания привес от рождения до 6 месяцев составил: симментальская - 761 г, голштинская - 716 г, симментальская × голштинская - 750 г, абердин-ангусская × голштинская - 833 г, Шароле × голштинская - 804 г и зебу × симментальская - 844 г. В результате был сделан вывод, что сбалансированное питание положительно влияет на динамику роста и развитие всех исследуемых пород. The research was carried out at the training center for animal husbandry and horse breeding of the Azerbaijan State Agrarian University. Several breeds of cows have been studied. At the age of 6 months, the average weight of the representatives of the Simmental breed was 175 kg, Holstein - 163 kg, Simmental × Holstein - 171 kg, Aberdeen Angus × Holstein - 178 kg, Charolais × Holstein - 176 kg and Zebu × Simmental - 192 kg. The aim of the study was to determine the genotype with the optimal result of growth and development. As a result of feeding, the weight gain from birth to 6 months was: Simmental - 761 g, Holstein - 716 g, Simmental × Holstein - 750 g, Aberdeen-Angus × Holstein - 833 g, Charolais × Holstein - 804 g and Zebu × Simmental - 844 g. As a result, it was concluded that a balanced diet has a positive effect on the dynamics of growth and development of all the studied breeds.

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Mason, PJ, MF Sonati, D. MacDonald, C. Lanza, D. Busutil, M. Town, CM Corcoran, JS Kaeda, DJ Stevens, and S. al-Ismail. "New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia." Blood 85, no. 5 (March 1, 1995): 1377–80. http://dx.doi.org/10.1182/blood.v85.5.1377.bloodjournal8551377.

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We have identified the glucose-6-phosphate dehydrogenase mutations responsible for enzyme deficiency in nine individuals with chronic nonspherocytic hemolytic anemia. We found the variants Tokyo, Iowa, Shinshu, and Guadalajara in British subjects and Kobe in an Italian. In addition we have determined the variant Corum has the mutation 820 G-->A and have found in British subjects the mis-sense mutations 224 T-->C, 488 G-->A and 833 C-->T which have not been described before. Some, but not all, of the mutations involve amino acids located near putative substrate binding sites.

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9

Kostrykin, V., and R. Schrader. "Cluster Properties of One Particle Schrödinger Operators. II." Reviews in Mathematical Physics 10, no. 05 (July 1998): 627–83. http://dx.doi.org/10.1142/s0129055x98000203.

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We continue the study of cluster properties of spectral and scattering characteristics of Schrödinger operators with potentials given as a sum of two wells, begun in our preceding article [Rev. Math. Phys. 6 (1994) 833–853] and where we determined the leading behaviour of the spectral shift function and the scattering amplitude as the separation of the wells tends to infinity. In this article we determine the explicit form of the subleading contributions, which in particular show strong oscillatory behaviour. Also we apply our methods to the critical and subcritical double well problems.

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Kiran, Shashi, Teena Bansal, and Pardeep Jakhar. "Aneurysm of interventricular septum: what an anaesthesiologist must know." Anaesthesia, Pain & Intensive Care 25, no. 6 (December 19, 2021): 832–33. http://dx.doi.org/10.35975/apic.v25i6.1714.

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Aneurysm of interventricular septum (IVSA) is a rare congenital anomaly. It has been documented in isolation but is seen in association with congenital heart disease in 0.3% of cases and in association with ventricular septal defect in 19% of cases. Etiologies are considered to be idiopathic formation, trauma, infection or spontaneous closure of pre-existing ventricular septal defect. Clinical manifestations are variable, some patients are asymptomatic whereas others can present with hemodynamic compromise. Key words: Anesthesia; Cardiac aneurysm Citation: Kiran S, Bansal T, Jakhar P. Aneurysm of interventricular septum: what an anesthesiologist must know. Anaesth. pain intensive care 2021;25(6):832–833; DOI: 10.35975/apic.v25i6.1714

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Books on the topic "833/.6"

1

Koltai, Denes. Theoretical, economic and regional issues of adult education. Budapest: IIZ/DVV, 2002.

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1879-1940, Klee Paul, and Manheim Ralph 1907-, eds. The novices of Sais. Brooklyn, N.Y: Archipelago Books, 2005.

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Gillam, Carey. Whitewash. Washington, DC: Island Press/Center for Resource Economics, 2017. http://dx.doi.org/10.5822/978-1-61091-833-6.

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Boulter, Carolyn J., Michael J. Reiss, and Dawn L. Sanders, eds. Darwin-Inspired Learning. Rotterdam: SensePublishers, 2015. http://dx.doi.org/10.1007/978-94-6209-833-6.

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A, Hoffmann E. T. Contes fantastiques. [Genève: Editions RVG, 1986.

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Schwarzes Mädchen, weisser Fremder: Studien zur Konstruktion von 'Rasse' und Geschlecht in Heinrich von Kleists Erzählung Die Verlobung in St. Domingo. Würzburg: Königshausen & Neumann, 2002.

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Public-Private Partnerships for Sustainable Development. MDPI, 2019. http://dx.doi.org/10.3390/books978-3-03897-833-6.

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Planning the Family in Egypt: New Bodies, New Selves (CMES Modern Middle East Series). University of Texas Press, 2002.

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Planning the Family in Egypt: New Bodies, New Selves (CMES Modern Middle East Series). University of Texas Press, 2002.

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Book chapters on the topic "833/.6"

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Wood, Henry. "833 Henry Wood From Cape St Johns,8 6 Jan. [16]86." In The Local Correspondence of the Royal African Company of England, 1681–1699, Vol. 2: The English in West Africa, 1685–1688, edited by Robin Law, 352. British Academy, 2001. http://dx.doi.org/10.1093/oseo/instance.00104728.

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Paschalis, Michael. "Book 11." In Virgil's Aeneid, 358–79. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198146889.003.0012.

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Abstract Aeneas erects on a ‘tumulus ‘ a ‘tropaeum ‘ clothed ( ‘induit ‘) with I\llezentius ‘ arms and armour ( ‘exuuias ‘) and dedicates it to I\!Iars. In 10. 762ff. Orion-like Mezentius was seen brandishing a huge spear, the trunk of an ash-tree [86pv], and in 10. 833-6 he was seen washing his wound in the waters of the Tiber and leaning against a tree-trunk ( ‘arboris acclinis trunco ‘), whi]e his helmet was hanging from the boughs of the tree. Now the tree-trunk is stripped of its leaves and clothed with l\1ezentius ‘ ‘exuuiae ‘. A ‘tumulus ‘ is ‘terra tumens ‘ and interacts semantically with ‘exuuiae ‘ ( ‘empty ‘ armour). The relation of tree-trunk [86pv] to ‘tumulus ‘ and ‘exuuiae ‘ (the latter include I\llezentius ‘ broken ‘tela ‘, Sopa-ra) varies the relation of Laocoon ‘s spear [86pv] to the hollow of the Wooden Horse [S6pv]. The trophy is in addition an offering [bwpoJJ] to a god.

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"§ 6. Conflict with earlier rights." In International Trade Mark and Signs Protection, edited by Paul Lange, 833–40. Nomos, 2010. http://dx.doi.org/10.5771/9783845266404-833.

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Malfettes, Stéphane. "Chapitre 6. Instances et stratégies de communication." In Les Mots distordus, 83–97. Éditions Mélanie Seteun, 2000. http://dx.doi.org/10.4000/books.ms.833.

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Conference papers on the topic "833/.6"

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Orre, Lukas, Elena Panizza, Vitaliy Kaminskyy, Torbjörn Gräslund, Boris Zhivotovsky, and Janne Lehtiö. "Abstract 833: S100A4 interacts with p53 in the nucleus promoting its degradation." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-833.

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Suh, Nanjoo, Bandaru S. Reddy, Shiby Paul, Andrew DeCastro, Hong Jin Lee, Amanda K. Smolarek, Jae Young So, et al. "Abstract 833: Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/beta-catenin/cyclin D1 signaling pathway in rats." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-833.

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