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Journal articles on the topic "822/.009 b"
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Marcucci, Guido, K. Mrózek, A. S. Ruppert, K. Maharry, J. E. Kolitz, R. J. Mayer, M. J. Pettenati, et al. "t(8;21) Acute Myeloid Leukemia (AML) Differs from inv(16) AML in Pretreatment Characteristics, Outcome and Prognostic Factors Predicting Outcome: A Cancer and Leukemia Group B (CALGB) Study." Blood 104, no. 11 (November 16, 2004): 2017. http://dx.doi.org/10.1182/blood.v104.11.2017.2017.
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Abstract Since t(8;21) and inv(16) disrupt core binding factor in AML and confer a favorable prognosis, these cytogenetic groups are often treated similarly, but hitherto have not been compared in a large study. We compared 144 adult AML patients (pts) with t(8;21) with 168 with inv(16) enrolled on the cytogenetic study CALGB 8461. t(8;21) pts were less frequently white (P=.01), had lower hemoglobin levels (P=.03), WBC (P<.001) and % blood (P<.001) and BM blasts (P=.005), and had more frequently secondary chromosome aberrations (P<.001) than inv(16) pts, who more often had extramedullary disease (P<.001). Pts were induced with cytarabine/daunorubicin (AD) or cytarabine/daunorubicin/etoposide ±PSC833(ADE±P). Complete remission (CR) was achieved by 89% of t(8;21) and 87% of inv(16) pts. Upon multivariable analysis (MVA), non-white race (P=.006), lower platelets (P=.01) and higher BM blasts (P=.004) predicted negatively for CR in t(8;21), and lower platelets (P=.009) and hepatomegaly (P=.04) in inv(16) pts. Non-whites with t(8;21) had 5.7 times the odds of not achieving CR as whites. For the entire group (median follow-up 6.4 yrs), the estimated 5-yr overall survival (OS) and cumulative incidence of relapse (CIR) were 51% and 53%, respectively. Pts with t(8;21) showed a trend for shorter OS (46% vs 54%; P=.17) but no difference in CIR compared with inv(16) pts. Upon MVA, t(8;21) pts had worse OS than inv(16) pts (HR 1.5; P=.04), once adjusting for age, platelets, and WBC. Following first relapse, the 5-yr survival of t(8;21) pts (n=58) was shorter than that of inv(16) pts (n=74) (14% vs 36%; P=.01); in an age-adjusted model, the risk of death was 1.8 times higher for t(8;21) pts (P=.005). In a subanalysis of pts <60 yrs, consolidation therapy with multi-course high-dose cytarabine (HDAC x3 or 4) significantly decreased CIR compared to single-course HDAC (x1) in t(8;21) (5-yr CIR, 35% vs 64%; P=.005) and inv(16) (5-yr CIR, 44% vs 70%; P =.03) pts. Upon MVA, consolidation with multi-course HDAC reduced CIR for both t(8;21) and inv(16), but other prognostic factors differed (see Table). For t(8;21), induction with ADE±P and higher platelets increased risk of relapse. However, relatively few pts received ADE±P so its prognostic impact requires confirmation. For inv(16), +22 and other secondary cytogenetic aberrations, and male sex were favorable prognostic factors. Multivariable analysis (MVA) for CIR in pts <60 yrs achieving CR on CALGB 8221, 8525, 9022, 9222, 9621 Variable t(8;21) HR (95% CI); P inv(16) HR (95% CI); P HR=Hazard Ratio, CI=confidence intervals —, not included in final model Consolidation:Single vs multi-course HDAC 4.5 (2.1-9.4); <.001 3.4 (1.7-6.6); <.001 Induction:ADE±P vs AD 2.6 (1.1-5.9); .02 1.4 (0.6-3.2); .41 log(platelets) 1.8 (1.2-2.9); .007 — Secondary cytogenetics — 0.2 (<0.1-0.5); .002 Male vs Female — 0.5 (0.3-0.9); .03 In summary, once pretreatment factors and therapy are considered, the outcome of t(8;21) AML appears inferior to that of inv(16). Although these data should be confirmed prospectively, our analysis suggests that future studies should report the outcomes of pts with t(8;21) and inv(16) separately, and seek to identify and target therapeutically leukemogenic mechanisms accountable for these clinical differences.
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Park, Hyunjin, Kyu Hyoung Lee, Minsu Heo, Sang-il Kim, and Hyun-Sik Kim. "Strategies for the High Average zT in the Electron-Doped SnTe." International Journal of Energy Research 2023 (December 15, 2023): 1–14. http://dx.doi.org/10.1155/2023/5512034.
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We propose a new strategy to achieve a high average zT in electron-doped SnTe by applying the two-band (TB) and single parabolic band (SPB) models to the electronic transport properties of Sn0.97M0.03Te ( M = Ga , In, Bi, and Sb) reported in the literature. To achieve a high average zT at temperatures from 300 to 823 K, both zT at 300 and 823 K should be high with a steadily increasing zT over the temperatures. The p-type SnTe is known to have a light valence band and a heavy valence band that are approximately 0.40 eV apart. The Bi-doped SnTe exhibits one of the highest zT among all the other doped samples at 300 K (0.09) and the highest zT at 823 K (0.9), with a steadily increasing zT in between. The TB model confirms the presence of the resonant state at 300 K which is responsible for the high zT at 300 K. The B-factor, which is related to the theoretical maximum zT, calculated by the SPB model indicates a steady increase in zT with increasing temperature. The temperature-dependent B-factor of the Bi-doped SnTe suggests that the initial position of its Fermi level at 300 K calculated by the TB model may be responsible for the temperature coefficient of the B-factor, which determines the zT at 823 K. According to the SPB model, experimental zT of 0.9 of the Bi-doped SnTe can be further improved to 1.03 (14% improvement) at 823 K upon carrier concentration optimization. To achieve a high average zT in SnTe, electron doping with a dopant that forms a resonant state and placing the Fermi level at the light valence band in the vicinity of the heavy valence band maximum are both essential.
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Massey, Heather, Paul Gorczynski, C. Mark Harper, Lisa Sansom, Kieren McEwan, Alla Yankouskaya, and Hannah Denton. "Perceived Impact of Outdoor Swimming on Health: Web-Based Survey." Interactive Journal of Medical Research 11, no. 1 (January 4, 2022): e25589. http://dx.doi.org/10.2196/25589.
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Background Outdoor swimming in lakes, lidos (outdoor pools), rivers, and the sea has grown in popularity in many countries, including the United Kingdom. Many anecdotal accounts indicate improvements in medical conditions, which are considered a consequence of outdoor swimming. Objective The aim of this study is to better understand outdoor swimmers’ perceptions of their health and the extent to which participation impacted their existing self-reported symptoms. Methods A survey was conducted to investigate outdoor swimming behaviors and reports of any diagnosed medical conditions. Medical conditions were coded into categories, and descriptive statistics were generated regarding the outdoor swimmers’ behaviors and the effect that outdoor swimming had on their medical symptoms if any. The medical categories were clustered into five larger categories based on their prevalence in the current sample: mental health; musculoskeletal and injury; neurological; cardiovascular and blood disease; and other, which comprises inflammatory, immune, endocrine, and respiratory conditions. Results In total, 722 outdoor swimmers responded, of whom 498 (68.9%) were female. The probability of outdoor swimming having some positive impact on health across all medical categories was 3.57 times higher compared with no impact (B=1.28, 95% CI 0.63-1.91; P<.001), 44.32 times higher for the mental health category (B=3.79, 95% CI 2.28-5.30; P<.001), 5.25 times higher for musculoskeletal and injury category (B=1.66, 95% CI 0.52-2.79; P=.004), and 4.02 times higher for the other category (B=1.39, 95% CI 0.27-2.51; P=.02). Overall, outdoor swimming was associated with perceived reductions in symptoms of poor mental health (χ22=25.1; P<.001), musculoskeletal and injury (χ22=8.2; P=.04), cardiovascular and blood (χ22=14.7; P=.006), and other conditions (χ22=18.2; P<.001). Conclusions Physical activity in the form of outdoor swimming is perceived to have positive impacts on health and is associated with perceived symptom reductions in mental health, musculoskeletal and injury, and cardiovascular and blood conditions. This study cannot provide causal relationships or provide mechanistic insights. However, it does provide a starting point for more targeted prospective intervention research into individual conditions or categories of conditions to establish the impact in those who choose to start outdoor swimming.
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Sumiati, Neneng Tati, and Syanindia Annisa Dewi. "The Relationship of Severity Level of Autism and Parent’s Unconditional Love on Children with Autism Moderated by Religiosity and Social Support." Jurnal Psikologi 20, no. 2 (October 31, 2021): 187–204. http://dx.doi.org/10.14710/jp.20.2.187-204.
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Children with autism have difficulties in social interaction, lack of communication, and repetitive behavior. Thoseconditions make parents come to grips with several drawbacks in taking care of their autistic children. Thepurpose of this study was to determine the relationship between the severity level of autism and the unconditionallove of parents, moderated by religiosity and social support. This study was using a quantitative approach withstructural equation model (SEM) analysis. Participants in this study were 200 parents of children with AutismSpectrum Disorder (ASD) aged 2-17 years old and were selected by the non-probability sampling technique. Themeasurements applied in this study were unconditional love scale, taken from Porter Parent Acceptance scale,which consists of four items (α = .802; AVE = .628), social support scale, which consists of three items (α = .703;AVE= .628), Brief Multidimensional Measure of Religiousness/Spirituality, which consists of ten items (α =.952; AVE= .699), and Childhood Autism Rating Scale, which consists of four items (α = .756; AVE= .574). Theresult indicated that the unconditional love of parents was significantly affected by severity level of autism, b = -.162; t(196) = 2.849, p = .005; religiosity, b = .534; t(196) = 7.101, p = .000; and social support, b = .157; t(196)= 2.426, p = .016. Religiosity was proven to be essential in moderating the relationship of severity level of autismand unconditional love, b = .249; t(196) = 3.262, p = .001); while social support was not, b = -.020; t(196) = .293,p = .770. Religiosity could help maintain the unconditional love of parents for their autistic children, while socialsupport was not enough to buffer stress caused by them. Thus, parents of children with autism are urged toincrease their level of religiosity
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Boekhout, Janet M., Brenda A. J. Berendsen, Denise A. Peels, Catherine A. W. Bolman, and Lilian Lechner. "Physical Impairments Disrupt the Association Between Physical Activity and Loneliness: A Longitudinal Study." Journal of Aging and Physical Activity 27, no. 6 (December 1, 2019): 787–96. http://dx.doi.org/10.1123/japa.2018-0325.
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This study explores the association between physical activity (PA), loneliness, and the presence of physical chronic impairments among single older adults. A longitudinal study (N = 575; mean age 76 ± 8 years) was conducted. The association between self-reported weekly minutes of moderate to vigorous PA, loneliness, and presence of physical impairments was assessed with multilevel analyses at baseline, 3 months, and 6 months. Improvements in moderate to vigorous PA were associated with decreases in loneliness (B = −0.09, SE = 0.04, p = .020); this association became nonsignificant when including the presence of physical impairments in the analyses (p = .824), which in itself was positively associated with loneliness (B = 0.51, SE = 0.10, p < .001). Findings indicate that physical impairments have a larger influence on loneliness than the level of PA. Interventions targeting PA and loneliness should tailor specifically to physical impairments.
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Lee, Shing Fung, Miguel Angel Luque-Fernandez, Yu Hui Chen, Paul J. Catalano, Chi Leung Chiang, Eric Yuk-Fai Wan, Ian Chi-Kei Wong, Ming Hui Chen, and Andrea K. Ng. "Doxorubicin and subsequent risk of cardiovascular diseases among survivors of diffuse large B-cell lymphoma in Hong Kong." Blood Advances 4, no. 20 (October 21, 2020): 5107–17. http://dx.doi.org/10.1182/bloodadvances.2020002737.
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Abstract Evidence regarding the dose-related impact of doxorubicin on subsequent cardiovascular diseases (CVDs) in Asian patients with diffuse large B-cell lymphoma (DLBCL) without preexisting CVDs is lacking. From a territory-wide electronic database in Hong Kong, we identified adults who were diagnosed with DLBCL and treated with chemotherapy between 2000 and 2018. We evaluated the patients for incident CVDs (including ischemic heart disease, heart failure, and cardiomyopathy). We evaluated the cause-specific cumulative incidence (csCI) of CVD with levels of doxorubicin exposure by using flexible parametric competing risk analysis and adjusting for demographics, comorbidities, therapeutic exposure, cardiovascular risk factors, and lifestyle factors. Controls were age- and sex-matched to DLBCL patients. We analyzed 2600 patients and 13 000 controls. The adjusted cause-specific hazard ratio (HR) for CVD in patients treated with >500 mg doxorubicin compared with non-doxorubicin regimens was 2.65 (95% confidence interval [CI], 1.23-5.74; P = .013). The 5-, 10-, and 15-year csCIs were 8.2%, 11.3%, and 12.8% in patients vs 3.1%, 4.4%, and 5.2% in controls, respectively. Hypertension (HR, 6.20; 95% CI, 0.79-48.44; P = .082) and use of aspirin/angiotensin-converting enzyme inhibitor/beta-blocker at baseline (HR, 2.13-4.63; P < .001 to .002) might confer a higher risk of subsequent CVDs. In this Hong Kong population-based study, doxorubicin exposure (absolute dose >500 mg), together with hypertension or baseline use of medication for cardiovascular risk factors, was found to be associated with an increase in csCIs of CVDs. Tailoring therapeutic strategies to underlying CVD risk factors and risk-adapted monitoring and follow-up of susceptible DLBCL patients are advisable.
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Battaglin, Francesca, Harris Krause, Andrew Elliot, Jim Abraham, Shivani Soni, Sandra Algaze, Priya Jayachandran, et al. "SETD2 gene expression and the molecular landscape of colorectal cancer (CRC)." Journal of Clinical Oncology 41, no. 4_suppl (February 1, 2023): 184. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.184.
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184 Background: SETD2, a key methyltransferase modulating histone 3 gene transcription, has been shown to act as a tumor suppressor gene by reducing oxidative stress, colonic inflammation and tumorigenesis in animal models. SETD2 gene expression has been reported to be significantly downregulated in CRC and linked with poorer patient survival. Additionally, SETD2 plays an important role in DNA repair and loss of function mutations have been associated with increased tumor mutational burden (TMB), mismatch repair (MMR) deficiency, and benefit from immunotherapy. Hence, we aimed to characterize the molecular features associated with SETD2 gene expression in CRC. Methods: 15,425 CRC tumors tested at Caris Life Sciences (Phoenix, AZ) with NextGen Sequencing on DNA (592 genes or whole exome sequencing), RNA (whole transcriptome sequencing), and IHC were analyzed. SETD2-high and -low expression were defined as ≥ top and < bottom quartile of SETD2 transcripts per million (TPM), respectively. Cell infiltration in the tumor microenvironment (TME) was estimated by QuantiSEQ. Mann-Whitney U and X2/Fisher-Exact tests were applied where appropriate, with P-values adjusted for multiple comparisons ( q < .05). Gene expression profiles were analyzed for transcriptional signatures predictive of response to immunotherapy (T cell-inflamed) and MAPK pathway activation (MPAS). Real-world overall survival information was obtained from insurance claims data and Kaplan-Meier estimates were calculated for molecularly defined patients. Results: SETD2 expression was significantly increased in left-sided/rectal compared to right-sided tumors (median TPM [mTPM] 55.8 vs 51.1, q < .001). SETD2 mutations were associated with reduced SETD2 expression in pMMR/MSS CRC (mTPM 37.9 vs 54.3 in WT, q < .001), although not statistically significant in dMMR/MSI-H CRC (mTPM 43.6 vs 51.7 in WT, P = .17). Compared to SETD2-high tumors, SETD2-low was associated with increased rates of TMB-high (10.4% vs 8.2%, P = .009), dMMR/MSI-H (7.3% vs 5.6%, P = .02), and PD-L1 IHC levels (4.4% vs 2.5%, q < .002). Only minor differences in gene mutation and copy number rates were observed between SETD2-high and -low tumors , whereas SETD2-high TME was associated with increased immune cell infiltration, including neutrophils, B cells, NK cells, M2 macrophages, and dendritic cells ( q < .05). SETD2-high was also associated with increased T cell-inflamed and MPAS signatures (152% and 159% median increase, respectively, q < .001), regardless of tumor MMR status. Among dMMR/MSI-H CRC, SETD2-high tumors receiving immune checkpoint inhibitors had longer time-on-treatment (HR: 0.39, 95% CI: 0.2-0.76, P = .005) and a trend towards longer OS (HR: 0.29, 95% CI: 0.07-1.2, P = .069). Conclusions: Our data show distinct immune biomarkers and TME cell infiltration associated with SETD2 gene expression in CRC. These findings support a key role for SETD2 in modulating anti-tumor immunity and TME.
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Hsu, R., E. N. Maslen, and N. Ishizawa. "A synchrotron X-ray study of the electron density in Y2BaCuO5." Acta Crystallographica Section B Structural Science 52, no. 4 (August 1, 1996): 569–75. http://dx.doi.org/10.1107/s0108768196000250.
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The deformation density (Δρ) for Y2BaCuO5, barium diyttrium cuprate, determined by single-crystal X-ray diffraction with synchrotron radiation, is affected to only a limited degree by the bonding interactions involving the O anions. Electron density is strongly depleted along the cation–cation contacts within the mirror plane in the structure and is transferred to regions between mirror planes that do not lie along short cation–cation vectors. The structural geometry for the CuO5 moiety, with the Cu atom in the +2 state, closely resembles that of the Cu2O5 group in YBa2Cu3O7−δ , for which the +3 state involvement for Cu has been suggested. Space group Pnma, orthorhombic, Mr = 458.68, a = 12.1793 (7), b = 5.6591 (5), c = 7.1323 (4) Å, V = 491.6 Å3, Z = 4, Dx = 6.197 Mg m−3, λ = 0.9 Å, μ 0.9 = 28.893 mm−1, F(000) = 812, T = 293 K, R = 0.020, wR = 0.020, S = 3.09 (5) for 2225 unique reflections.
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Bradford, Porcia T., Susan S. Devesa, William F. Anderson, and Jorge R. Toro. "Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases." Blood 113, no. 21 (May 21, 2009): 5064–73. http://dx.doi.org/10.1182/blood-2008-10-184168.
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Abstract There have been no prior large population-based studies focusing on cutaneous lymphomas (CL) in the United States. Using the Surveillance, Epidemiology and End Results (SEER) program data, we analyzed age-adjusted CL incidence rates (IRs) and survival rates by sex and race/ethnicity. There were 3884 CLs diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years). Males had a statistically significant higher IR of CL than females (14.0 vs 8.2/1 000 000 person-years, respectively; male-female IR ratio [M/F IRR] = 1.72; P < .001). CL IRs were highest among blacks and non-Hispanic whites (both 11.5/1 000 000 person-years), followed by Hispanic whites (7.9) and Asian/Pacific Islanders (7.1). The CTCL IR was highest among blacks (10.0/1 000 000 person-years), whereas the CBCL IR was highest among non-Hispanic whites (3.5). Over the past 25 years, the CL IR increased from 5.0/1 000 000 person-years during 1980-1982 to 14.3 during 2001-2003. During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential leveling off of IRs. CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities.
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Held, Gerhard, Samira Zeynalova, Niels Murawski, Marita Ziepert, Barbara Kempf, Andreas Viardot, Martin Dreyling, et al. "Impact of Rituximab and Radiotherapy on Outcome of Patients With Aggressive B-Cell Lymphoma and Skeletal Involvement." Journal of Clinical Oncology 31, no. 32 (November 10, 2013): 4115–22. http://dx.doi.org/10.1200/jco.2012.48.0467.
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Purpose To study clinical presentation, outcome, and the role of radiotherapy in patients with aggressive B-cell lymphoma and skeletal involvement treated with and without rituximab. Patients and Methods Outcome of patients with skeletal involvement was analyzed in a retrospective study of nine consecutive prospective trials of the German High-Grade Non-Hodgkin lymphoma Study Group. Results Of 3,840 patients, 292 (7.6%) had skeletal involvement. In the MabThera International Trial (MInT) for young good-prognosis patients and the Rituximab With CHOP Over 60 Years (RICOVER-60) study for elderly patients, the randomized addition of rituximab improved event-free survival (EFS; hazard ratio for MInT [HRMInT] = 0.4, P > 001; hazard ratio for RICOVER-60 [HRRICOVER-60] = 0.6, P > .001) and overall survival (OS; HRMInT = 0.4, P < .001; HRRICOVER-60 = 0.7, P = .002) in patients without skeletal involvement, but failed to improve the outcome of patients with skeletal involvement (EFS: HRMInT = 1.4, P = .444; HRRICOVER-60 = 0.8, P = .449; OS: HRMInT = 0.6, P = .449; HRRICOVER-60 = 1.0, P = .935). Skeletal involvement was associated with a worse outcome after cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus rituximab (HREFS = 1.5, P = .048; HROS = 1.1; P = .828), but not after CHOP without rituximab (HREFS = 0.8, P = .181; HROS = 0.7, P = .083). In contrast to rituximab, additive radiotherapy to sites of skeletal involvement was associated with a decreased risk (HREFS = 0.3, P = .001; HROS = 0.5; P = .111). Conclusion Rituximab failed to improve the outcome of patients with diffuse large B-cell lymphoma with skeletal involvement, although our data suggest a beneficial effect of radiotherapy to sites of skeletal involvement. Whether radiotherapy to sites of skeletal involvement can be spared in cases with a negative positron emission tomography after immunochemotherapy should be addressed in appropriately designed prospective trials.
Books on the topic "822/.009 b"
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Claire, Berman, and Shi Xirong, eds. Shi shui zai shuo hua. Taibei Shi: Xin miao wen hua shi ye you xian gong si, 2008.
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Stoppard, Tom. Kenneth Tynan: Theatre Writings. Hern Books, Limited, Nick, 2018.
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The Center Cannot Hold: My Journey Through Madness. Hyperion, 2007.
Find full textBook chapters on the topic "822/.009 b"
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"8.2 Hormonsysteme." In Taschenatlas Biochemie des Menschen, edited by Jan Koolman and Klaus-Heinrich Röhm. Stuttgart: Georg Thieme Verlag, 2019. http://dx.doi.org/10.1055/b-0039-167423.
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"8.2 Ellenbogen, Unterarm." In Orthopädie und Unfallchirurgie essentials, edited by Steffen Ruchholtz and Dieter Christian Wirtz. Stuttgart: Georg Thieme Verlag, 2019. http://dx.doi.org/10.1055/b-0039-168727.
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"8.2 Perkutane Sklerosierung von lymphatischen Malformationen." In Interventionelle Radiologie, edited by Andreas H. Mahnken, Christoph Thomas, and Kai Wilhelm. Stuttgart: Georg Thieme Verlag, 2019. http://dx.doi.org/10.1055/b-0039-169049.
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"8.2 Sekundäre Tumoren der Wirbelsäule Tumor sekundärer Wirbelsäulentumor sekundärer." In Expertise Orthopädie und Unfallchirurgie Wirbelsäule, edited by Gregor Stein, Peer Eysel, and Max Joseph Scheyerer. Stuttgart: Georg Thieme Verlag, 2019. http://dx.doi.org/10.1055/b-0039-167035.
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Simoniello, Maria, and Vittorio Ganfi. "Effects of National Language Policies on Local Varieties Campanian and Sicilian Case Studies." In Language Attitudes and Bi(dia)lectal Competence. Venice: Fondazione Università Ca’ Foscari, 2024. http://dx.doi.org/10.30687/978-88-6969-802-6/007.
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This study analyses the impact of institutional language policies on the status of two local varieties spoken in the area of Messina and in the province of Caserta, which are non-officially promoted in national laws concerning plurilingualism but specifically addressed in legislative measures at Regional level. In order to unveil the impact of language policy on speaker view of languages, this study offers a quantitative analysis, based on questionnaires and focusing on (a) speakers’ judgments about their regional languages; (b) local varieties collocation in their repertoires; (c) correlation between specific communicative situations and local varieties; (d) differences in linguistic prestige assignment among demographic classes of informants.
Conference papers on the topic "822/.009 b"
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Cavalli, Jessica, and Anita Cservenka. "Emotion Dysregulation Moderates the Association Between Stress and Problematic Marijuana Use." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.8.
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Objective. Marijuana is the most widely used illicit substance in the United States and in 2018 alone, an estimated 40.3 million adults reported using marijuana in the past year. This is concerning since growing research suggests that marijuana use is associated with adverse health and life outcomes, such as mental health issues, and cognitive impairment. Thus, determining factors that influence marijuana use-related problems is critical for understanding how to effectively implement prevention, intervention, and treatment efforts. Because research has proposed that emotion dysregulation is a transdiagnostic risk factor for substance use and addiction, the investigation of emotion regulation capabilities in marijuana users is warranted. Furthermore, since prior studies suggest that stress may lead to greater marijuana use-related problems, additional research into how emotion dysregulation may affect these relationships is needed. Thus, the current study examines how emotion dysregulation moderates the association between stress and problematic marijuana use in adults through an online survey. Methods. 852 adults reporting any lifetime marijuana use completed an online survey through Qualtrics. Participants completed a brief demographic questionnaire and were asked to report their past 30-day use of marijuana, alcohol, nicotine, and illicit substances. To assess past month problematic marijuana use, participants completed the Marijuana Problem Scale (MPS). To assess emotion dysregulation, participants completed the Difficulties in Emotion Regulation Scale (DERS). Participants completed the Perceived Stress Scale (PSS) and the Holmes-Rahe Life Stress Inventory (H-RLSI) to assess past month perceived stress and past year stressful life events, respectively. We investigated the association between scores on the DERS, PSS, and H-RLSI with scores on the MPS. Additionally, we conducted hierarchical multiple linear regression models to test whether emotion dysregulation, stress, and their interaction predicted problematic marijuana use. Results. Scores on the DERS (r = .53, p < .001), PSS (r = .13, p < .001), and H-RLSI (r = .32, p < .001) were significantly correlated with scores on the MPS. Additionally, emotion dysregulation (B = .32, p < .001), stressful life events (B = .21, p < .001), and their interaction (B = .07, p = .003) were significant predictors of problematic marijuana use. Finally, emotion dysregulation (B = .44, p < .001), perceived stress (B = -.18, p < .001), and their interaction (B = -.06, p = .04) were significant predictors of problematic marijuana use. Conclusion. These findings indicate that when examined separately, greater emotion dysregulation, experiencing more stressful life events in the past year, and experiencing more perceived stress in the past month were associated with greater problematic marijuana use in the past month. However, when examining the moderating role of emotion dysregulation, more stressful life events and less perceived stress predicted greater problematic marijuana use, and these associations were stronger at higher levels of emotion dysregulation. Overall, these results suggest that emotion dysregulation and greater stress may be risk factors for developing problematic marijuana use, and could be possible targets for prevention, intervention, and treatment efforts.
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Rahardjo, Setyo Sri, and Bhisma Murti. "Factors Associated with Service Performance among Community Health Center Employees in Karanganyar, Central Java." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.04.41.
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ABSTRACT Background: Based on the strategic plan of the Karanganyar Health Office, the good accreditation and performance assessment of community health center have not yet been achieved. This is inseparable from the performance of the employee service per-formance. This study aimed to determine factors associated with service performance among community health center employees in Karanganyar, Central Java. Subjects and Method: A cross-sectional study was carried out in 21 community health centers, Karanganyar, Central Java, in October-November. A sample of 210 employees in community health worker was selected by simple random sampling. The dependent variable was service performance. The independent variables were age, edu-cation, tenure, incentive, motivation, skill, satisfaction, accreditation status of commu-nity health center, and working environment. The data were collected by question-naire. The data were analyzed by a multiple logistic regression. Results: Service performance increased with age ≥38 years (b= 1.09; 95% CI= 0.19 to 1.99; p= 0.018), education ≥diploma 3 (b= -0.40; 95% CI= -1.67 to 0.87; p= 0.535), tenure ≥3 years (b= -0.71; 95% CI= -1.79 to 0.37; p= 0.199), good incentive (b= 0.96; 95% CI= -0.28 to 2.19; p= 0.128), good motivation (b= 0.93; 95% CI= 0.09 to 1.77; p= 0.030), good skill (b= 0.97; 95% CI= 0.06 to 1.88; p= 0.037), satisfied (b= 0.92; 95% CI= 0.05 to 1.78; p= 0.037), and good working environment (b= 0.95; 95% CI= 0.11 to 1.80; p= 0.026). Conclusion: Service performance in community health center employees increases with age ≥38 years, ≥diploma, ≥3 years of service, good incentive, good motivation, good skill, satisfied, and good working environment. Keywords: service performance, employee, community health center Correspondence: Mujiran. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java, Indonesia. Email: mujiransismiharjo@gmail.-com. Mobile: +62 812-2603-915. DOI: https://doi.org/10.26911/the7thicph.04.41